JP2022528840A - 安定性が増加した修飾オリゴヌクレオチド - Google Patents

安定性が増加した修飾オリゴヌクレオチド Download PDF

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JP2022528840A
JP2022528840A JP2021557374A JP2021557374A JP2022528840A JP 2022528840 A JP2022528840 A JP 2022528840A JP 2021557374 A JP2021557374 A JP 2021557374A JP 2021557374 A JP2021557374 A JP 2021557374A JP 2022528840 A JP2022528840 A JP 2022528840A
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modified
binding
sirna
subunits
formula
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JP2022528840A5 (enExample
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コボロバ，アナスタシア
モーリス ルネ ジャン ルー，ロイク
ヤマダ，ケン
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University of Massachusetts Amherst
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
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    • C12N2320/00—Applications; Uses
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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JP2021557374A 2019-03-26 2020-03-26 安定性が増加した修飾オリゴヌクレオチド Pending JP2022528840A (ja)

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JP2025015181A JP2025072451A (ja) 2019-03-26 2025-01-31 安定性が増加した修飾オリゴヌクレオチド

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US201962824136P 2019-03-26 2019-03-26
US62/824,136 2019-03-26
US201962826454P 2019-03-29 2019-03-29
US62/826,454 2019-03-29
US201962864792P 2019-06-21 2019-06-21
US62/864,792 2019-06-21
PCT/US2020/025017 WO2020198509A2 (en) 2019-03-26 2020-03-26 Modified oligonucleotides with increased stability

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US (2) US11820985B2 (enExample)
EP (1) EP3946369A4 (enExample)
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EP3781677A4 (en) 2018-04-16 2022-01-19 University of Massachusetts COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING
US11279930B2 (en) 2018-08-23 2022-03-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
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US11820985B2 (en) 2019-03-26 2023-11-21 University Of Massachusetts Modified oligonucleotides with increased stability
KR20220047989A (ko) 2019-08-09 2022-04-19 유니버시티 오브 매사추세츠 Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
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WO2020198509A3 (en) 2020-11-05
WO2020198509A2 (en) 2020-10-01
JP2025072451A (ja) 2025-05-09
US20240141362A1 (en) 2024-05-02
EP3946369A2 (en) 2022-02-09
EP3946369A4 (en) 2023-10-18
US20200385740A1 (en) 2020-12-10
US11820985B2 (en) 2023-11-21

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