CA2707009A1 - Methods for inhibiting fascin - Google Patents

Info

Publication number

CA2707009A1

CA2707009A1 CA2707009A CA2707009A CA2707009A1 CA 2707009 A1 CA2707009 A1 CA 2707009A1 CA 2707009 A CA2707009 A CA 2707009A CA 2707009 A CA2707009 A CA 2707009A CA 2707009 A1 CA2707009 A1 CA 2707009A1

Authority

CA

Canada

Prior art keywords

fascin

actin

inhibitor

amino acids

binding

Prior art date

2007-11-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 108090000786 Fascin Proteins 0.000 title claims abstract description 586
• 102000004204 Fascin Human genes 0.000 title claims abstract description 581
• 238000000034 method Methods 0.000 title claims abstract description 147
• 230000002401 inhibitory effect Effects 0.000 title claims abstract description 76
• 206010027476 Metastases Diseases 0.000 claims abstract description 70
• 230000009401 metastasis Effects 0.000 claims abstract description 68
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 27
• 201000010099 disease Diseases 0.000 claims abstract description 22
• 230000005764 inhibitory process Effects 0.000 claims abstract description 21
• 241000124008 Mammalia Species 0.000 claims abstract description 9
• 230000027455 binding Effects 0.000 claims description 149
• 206010028980 Neoplasm Diseases 0.000 claims description 118
• 239000003795 chemical substances by application Substances 0.000 claims description 116
• 108010085238 Actins Proteins 0.000 claims description 113
• 102000007469 Actins Human genes 0.000 claims description 113
• 150000001875 compounds Chemical class 0.000 claims description 95
• 230000014509 gene expression Effects 0.000 claims description 94
• 238000012360 testing method Methods 0.000 claims description 93
• 150000001413 amino acids Chemical class 0.000 claims description 87
• 230000000694 effects Effects 0.000 claims description 87
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 74
• 150000007523 nucleic acids Chemical class 0.000 claims description 73
• 102000039446 nucleic acids Human genes 0.000 claims description 73
• 108020004707 nucleic acids Proteins 0.000 claims description 73
• 201000011510 cancer Diseases 0.000 claims description 64
• 108090000623 proteins and genes Proteins 0.000 claims description 64
• 206010006187 Breast cancer Diseases 0.000 claims description 54
• 208000026310 Breast neoplasm Diseases 0.000 claims description 54
• 239000003112 inhibitor Substances 0.000 claims description 54
• 102000002151 Microfilament Proteins Human genes 0.000 claims description 53
• 108010040897 Microfilament Proteins Proteins 0.000 claims description 53
• 239000012634 fragment Substances 0.000 claims description 52
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 51
• 241001465754 Metazoa Species 0.000 claims description 43
• 102000004169 proteins and genes Human genes 0.000 claims description 43
• 229920001184 polypeptide Polymers 0.000 claims description 41
• 229940082729 Fascin inhibitor Drugs 0.000 claims description 30
• 238000011282 treatment Methods 0.000 claims description 30
• 208000037819 metastatic cancer Diseases 0.000 claims description 27
• 208000011575 metastatic malignant neoplasm Diseases 0.000 claims description 27
• 150000003839 salts Chemical class 0.000 claims description 26
• 239000013604 expression vector Substances 0.000 claims description 25
• 230000015572 biosynthetic process Effects 0.000 claims description 23
• 239000003814 drug Substances 0.000 claims description 22
• 238000003860 storage Methods 0.000 claims description 15
• 125000004429 atom Chemical group 0.000 claims description 14
• 229910052757 nitrogen Inorganic materials 0.000 claims description 12
• 208000017604 Hodgkin disease Diseases 0.000 claims description 10
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 10
• 125000000217 alkyl group Chemical group 0.000 claims description 9
• 201000001441 melanoma Diseases 0.000 claims description 9
• 230000004770 neurodegeneration Effects 0.000 claims description 9
• 208000029742 colonic neoplasm Diseases 0.000 claims description 8
• 238000004519 manufacturing process Methods 0.000 claims description 8
• 206010009944 Colon cancer Diseases 0.000 claims description 7
• 206010033128 Ovarian cancer Diseases 0.000 claims description 7
• 206010020718 hyperplasia Diseases 0.000 claims description 7
• 150000003384 small molecules Chemical class 0.000 claims description 7
• 230000009385 viral infection Effects 0.000 claims description 7
• 201000009030 Carcinoma Diseases 0.000 claims description 6
• 206010061535 Ovarian neoplasm Diseases 0.000 claims description 6
• 208000036142 Viral infection Diseases 0.000 claims description 6
• 208000035143 Bacterial infection Diseases 0.000 claims description 5
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
• 206010025323 Lymphomas Diseases 0.000 claims description 5
• 206010039491 Sarcoma Diseases 0.000 claims description 5
• 208000022362 bacterial infectious disease Diseases 0.000 claims description 5
• 208000035475 disorder Diseases 0.000 claims description 5
• 125000005843 halogen group Chemical group 0.000 claims description 5
• 230000004968 inflammatory condition Effects 0.000 claims description 5
• 208000028867 ischemia Diseases 0.000 claims description 5
• 230000001404 mediated effect Effects 0.000 claims description 5
• 230000001537 neural effect Effects 0.000 claims description 5
• 229910052760 oxygen Inorganic materials 0.000 claims description 5
• 230000000451 tissue damage Effects 0.000 claims description 5
• 231100000827 tissue damage Toxicity 0.000 claims description 5
• 206010003571 Astrocytoma Diseases 0.000 claims description 4
• 206010027406 Mesothelioma Diseases 0.000 claims description 4
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
• 125000003545 alkoxy group Chemical group 0.000 claims description 4
• 206010017758 gastric cancer Diseases 0.000 claims description 4
• 208000020816 lung neoplasm Diseases 0.000 claims description 4
• 230000002194 synthesizing effect Effects 0.000 claims description 4
• 208000017897 Carcinoma of esophagus Diseases 0.000 claims description 3
• 208000008839 Kidney Neoplasms Diseases 0.000 claims description 3
• 206010060862 Prostate cancer Diseases 0.000 claims description 3
• 206010038389 Renal cancer Diseases 0.000 claims description 3
• 201000007455 central nervous system cancer Diseases 0.000 claims description 3
• 201000010982 kidney cancer Diseases 0.000 claims description 3
• 208000032839 leukemia Diseases 0.000 claims description 3
• 201000005202 lung cancer Diseases 0.000 claims description 3
• 206010005003 Bladder cancer Diseases 0.000 claims description 2
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
• 201000001531 bladder carcinoma Diseases 0.000 claims description 2
• 201000005619 esophageal carcinoma Diseases 0.000 claims description 2
• 208000021045 exocrine pancreatic carcinoma Diseases 0.000 claims description 2
• 208000010749 gastric carcinoma Diseases 0.000 claims description 2
• 201000005296 lung carcinoma Diseases 0.000 claims description 2
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
• 201000011549 stomach cancer Diseases 0.000 claims description 2
• 201000000498 stomach carcinoma Diseases 0.000 claims description 2
• 208000010570 urinary bladder carcinoma Diseases 0.000 claims description 2
• 230000002485 urinary effect Effects 0.000 claims description 2
• 210000004881 tumor cell Anatomy 0.000 abstract description 64
• 239000000203 mixture Substances 0.000 abstract description 36
• 210000004027 cell Anatomy 0.000 description 228
• 108020004459 Small interfering RNA Proteins 0.000 description 111
• 239000004055 small Interfering RNA Substances 0.000 description 99
• OGYMUMAKGYYNHV-IJMHZYIBSA-N migrastatin Chemical class CC/1=C/[C@@H](C)[C@H](O)[C@@H](OC)\C=C\CC\C=C\C(=O)O[C@@H]\1[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1 OGYMUMAKGYYNHV-IJMHZYIBSA-N 0.000 description 72
• 229940024606 amino acid Drugs 0.000 description 55
• 235000001014 amino acid Nutrition 0.000 description 55
• 238000003556 assay Methods 0.000 description 45
• 241000699670 Mus sp. Species 0.000 description 42
• 235000018102 proteins Nutrition 0.000 description 39
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 37
• 230000012292 cell migration Effects 0.000 description 36
• 239000002609 medium Substances 0.000 description 35
• 125000003729 nucleotide group Chemical group 0.000 description 33
• 230000005012 migration Effects 0.000 description 31
• 238000013508 migration Methods 0.000 description 31
• 239000002773 nucleotide Substances 0.000 description 31
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 30
• 210000004072 lung Anatomy 0.000 description 30
• 239000000427 antigen Substances 0.000 description 29
• 108091007433 antigens Proteins 0.000 description 29
• 102000036639 antigens Human genes 0.000 description 29
• -1 that is Proteins 0.000 description 29
• 241000699666 Mus <mouse, genus> Species 0.000 description 24
• 108091027967 Small hairpin RNA Proteins 0.000 description 24
• 108020004999 messenger RNA Proteins 0.000 description 24
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 23
• 210000002966 serum Anatomy 0.000 description 21
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 20
• 125000000539 amino acid group Chemical group 0.000 description 20
• OGYMUMAKGYYNHV-UHFFFAOYSA-N migrastatin Natural products CC1=CC(C)C(O)C(OC)C=CCCC=CC(=O)OC1C(C)C(=O)CCCC1CC(=O)NC(=O)C1 OGYMUMAKGYYNHV-UHFFFAOYSA-N 0.000 description 20
• 229920000642 polymer Polymers 0.000 description 20
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 19
• 239000011616 biotin Substances 0.000 description 19
• 229960002685 biotin Drugs 0.000 description 19
• 235000020958 biotin Nutrition 0.000 description 19
• 230000000295 complement effect Effects 0.000 description 19
• 238000000338 in vitro Methods 0.000 description 19
• 108060003951 Immunoglobulin Proteins 0.000 description 18
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 18
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 18
• 102000018358 immunoglobulin Human genes 0.000 description 18
• 210000001519 tissue Anatomy 0.000 description 18
• 101001021925 Homo sapiens Fascin Proteins 0.000 description 17
• 230000000692 anti-sense effect Effects 0.000 description 17
• 238000001727 in vivo Methods 0.000 description 16
• 108020004414 DNA Proteins 0.000 description 15
• 230000006870 function Effects 0.000 description 15
• 230000003993 interaction Effects 0.000 description 15
• 239000000126 substance Substances 0.000 description 15
• HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 14
• 238000013500 data storage Methods 0.000 description 14
• 239000007788 liquid Substances 0.000 description 14
• 238000010232 migration assay Methods 0.000 description 14
• 108090000994 Catalytic RNA Proteins 0.000 description 13
• 102000053642 Catalytic RNA Human genes 0.000 description 13
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 13
• 206010061289 metastatic neoplasm Diseases 0.000 description 13
• 108091092562 ribozyme Proteins 0.000 description 13
• 239000000243 solution Substances 0.000 description 13
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 12
• 230000001394 metastastic effect Effects 0.000 description 12
• 235000004035 Cryptotaenia japonica Nutrition 0.000 description 11
• 102000007641 Trefoil Factors Human genes 0.000 description 11
• 235000015724 Trifolium pratense Nutrition 0.000 description 11
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 11
• 239000008188 pellet Substances 0.000 description 11
• 239000002953 phosphate buffered saline Substances 0.000 description 11
• 238000002360 preparation method Methods 0.000 description 11
• 229940124597 therapeutic agent Drugs 0.000 description 11
• 239000013598 vector Substances 0.000 description 11
• 108091030071 RNAI Proteins 0.000 description 10
• 239000011324 bead Substances 0.000 description 10
• 238000013461 design Methods 0.000 description 10
• 230000035772 mutation Effects 0.000 description 10
• 239000000047 product Substances 0.000 description 10
• 230000002829 reductive effect Effects 0.000 description 10
• 238000012216 screening Methods 0.000 description 10
• 239000007787 solid Substances 0.000 description 10
• 238000001890 transfection Methods 0.000 description 10
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 9
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
• 239000002253 acid Substances 0.000 description 9
• 238000010171 animal model Methods 0.000 description 9
• 239000000872 buffer Substances 0.000 description 9
• 238000003776 cleavage reaction Methods 0.000 description 9
• 238000000576 coating method Methods 0.000 description 9
• 239000002299 complementary DNA Substances 0.000 description 9
• 230000009368 gene silencing by RNA Effects 0.000 description 9
• 229940072221 immunoglobulins Drugs 0.000 description 9
• 210000003632 microfilament Anatomy 0.000 description 9
• 230000008569 process Effects 0.000 description 9
• 230000007017 scission Effects 0.000 description 9
• 239000011780 sodium chloride Substances 0.000 description 9
• 230000001225 therapeutic effect Effects 0.000 description 9
• 101150041968 CDC13 gene Proteins 0.000 description 8
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
• 208000027418 Wounds and injury Diseases 0.000 description 8
• 230000037396 body weight Effects 0.000 description 8
• 210000000481 breast Anatomy 0.000 description 8
• 230000001413 cellular effect Effects 0.000 description 8
• 239000011248 coating agent Substances 0.000 description 8
• 239000013078 crystal Substances 0.000 description 8
• 230000003247 decreasing effect Effects 0.000 description 8
• 238000002474 experimental method Methods 0.000 description 8
• 238000010265 fast atom bombardment Methods 0.000 description 8
• 238000012545 processing Methods 0.000 description 8
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 8
• 238000010186 staining Methods 0.000 description 8
• 230000004083 survival effect Effects 0.000 description 8
• 238000003786 synthesis reaction Methods 0.000 description 8
• 238000005160 1H NMR spectroscopy Methods 0.000 description 7
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 7
• 108010043121 Green Fluorescent Proteins Proteins 0.000 description 7
• 102000004144 Green Fluorescent Proteins Human genes 0.000 description 7
• 241000700605 Viruses Species 0.000 description 7
• 239000004480 active ingredient Substances 0.000 description 7
• 238000004458 analytical method Methods 0.000 description 7
• 230000000875 corresponding effect Effects 0.000 description 7
• 239000002552 dosage form Substances 0.000 description 7
• 102000015694 estrogen receptors Human genes 0.000 description 7
• 108010038795 estrogen receptors Proteins 0.000 description 7
• 239000012091 fetal bovine serum Substances 0.000 description 7
• 238000000799 fluorescence microscopy Methods 0.000 description 7
• 239000005090 green fluorescent protein Substances 0.000 description 7
• 230000001965 increasing effect Effects 0.000 description 7
• 238000011534 incubation Methods 0.000 description 7
• 238000012900 molecular simulation Methods 0.000 description 7
• 231100000252 nontoxic Toxicity 0.000 description 7
• 230000003000 nontoxic effect Effects 0.000 description 7
• 239000000523 sample Substances 0.000 description 7
• 239000006228 supernatant Substances 0.000 description 7
• 239000013603 viral vector Substances 0.000 description 7
• 230000029663 wound healing Effects 0.000 description 7
• 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 6
• 102000004190 Enzymes Human genes 0.000 description 6
• 108090000790 Enzymes Proteins 0.000 description 6
• 241000588724 Escherichia coli Species 0.000 description 6
• 102100036089 Fascin Human genes 0.000 description 6
• 241000282412 Homo Species 0.000 description 6
• 239000012097 Lipofectamine 2000 Substances 0.000 description 6
• 101001021922 Mus musculus Fascin Proteins 0.000 description 6
• 241000283973 Oryctolagus cuniculus Species 0.000 description 6
• 102000057297 Pepsin A Human genes 0.000 description 6
• 108090000284 Pepsin A Proteins 0.000 description 6
• 241000700159 Rattus Species 0.000 description 6
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
• 238000013459 approach Methods 0.000 description 6
• 229910052799 carbon Inorganic materials 0.000 description 6
• 239000003153 chemical reaction reagent Substances 0.000 description 6
• 210000001072 colon Anatomy 0.000 description 6
• 230000001419 dependent effect Effects 0.000 description 6
• 229940088598 enzyme Drugs 0.000 description 6
• 150000002148 esters Chemical class 0.000 description 6
• 239000001963 growth medium Substances 0.000 description 6
• 238000009396 hybridization Methods 0.000 description 6
• 150000007931 macrolactones Chemical class 0.000 description 6
• 230000007246 mechanism Effects 0.000 description 6
• 238000002493 microarray Methods 0.000 description 6
• 210000000056 organ Anatomy 0.000 description 6
• 230000002018 overexpression Effects 0.000 description 6
• 238000000159 protein binding assay Methods 0.000 description 6
• 210000001243 pseudopodia Anatomy 0.000 description 6
• 238000000746 purification Methods 0.000 description 6
• 230000009467 reduction Effects 0.000 description 6
• 239000000758 substrate Substances 0.000 description 6
• 238000013519 translation Methods 0.000 description 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
• 108010010803 Gelatin Proteins 0.000 description 5
• 230000002411 adverse Effects 0.000 description 5
• 230000029918 bioluminescence Effects 0.000 description 5
• 238000005415 bioluminescence Methods 0.000 description 5
• 230000000903 blocking effect Effects 0.000 description 5
• 239000000969 carrier Substances 0.000 description 5
• 230000004709 cell invasion Effects 0.000 description 5
• 230000006378 damage Effects 0.000 description 5
• 210000004443 dendritic cell Anatomy 0.000 description 5
• 238000009510 drug design Methods 0.000 description 5
• 239000008273 gelatin Substances 0.000 description 5
• 229920000159 gelatin Polymers 0.000 description 5
• 235000019322 gelatine Nutrition 0.000 description 5
• 235000011852 gelatine desserts Nutrition 0.000 description 5
• 238000003197 gene knockdown Methods 0.000 description 5
• 230000012010 growth Effects 0.000 description 5
• 229910052739 hydrogen Inorganic materials 0.000 description 5
• 238000001802 infusion Methods 0.000 description 5
• 210000004962 mammalian cell Anatomy 0.000 description 5
• 210000005075 mammary gland Anatomy 0.000 description 5
• 239000000463 material Substances 0.000 description 5
• 239000012528 membrane Substances 0.000 description 5
• 238000010172 mouse model Methods 0.000 description 5
• 229940111202 pepsin Drugs 0.000 description 5
• 229940002612 prodrug Drugs 0.000 description 5
• 239000000651 prodrug Substances 0.000 description 5
• 102000003998 progesterone receptors Human genes 0.000 description 5
• 108090000468 progesterone receptors Proteins 0.000 description 5
• 230000001105 regulatory effect Effects 0.000 description 5
• 210000003491 skin Anatomy 0.000 description 5
• 231100000419 toxicity Toxicity 0.000 description 5
• 230000001988 toxicity Effects 0.000 description 5
• 238000013518 transcription Methods 0.000 description 5
• 230000035897 transcription Effects 0.000 description 5
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 4
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 4
• 102100035181 Plastin-1 Human genes 0.000 description 4
• 108090000190 Thrombin Proteins 0.000 description 4
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 4
• 206010052428 Wound Diseases 0.000 description 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 4
• 208000026935 allergic disease Diseases 0.000 description 4
• 210000004102 animal cell Anatomy 0.000 description 4
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
• 238000004166 bioassay Methods 0.000 description 4
• 239000002775 capsule Substances 0.000 description 4
• 238000010367 cloning Methods 0.000 description 4
• 239000000539 dimer Substances 0.000 description 4
• 239000006185 dispersion Substances 0.000 description 4
• 229940079593 drug Drugs 0.000 description 4
• 238000001493 electron microscopy Methods 0.000 description 4
• 210000003811 finger Anatomy 0.000 description 4
• 108020001507 fusion proteins Proteins 0.000 description 4
• 102000037865 fusion proteins Human genes 0.000 description 4
• 239000000499 gel Substances 0.000 description 4
• 102000050987 human FSCN1 Human genes 0.000 description 4
• 239000001257 hydrogen Substances 0.000 description 4
• 238000003384 imaging method Methods 0.000 description 4
• 208000014674 injury Diseases 0.000 description 4
• 238000000464 low-speed centrifugation Methods 0.000 description 4
• 239000003120 macrolide antibiotic agent Substances 0.000 description 4
• 230000015654 memory Effects 0.000 description 4
• 108700003296 mouse fascin1 Proteins 0.000 description 4
• 108010087904 neutravidin Proteins 0.000 description 4
• 210000001672 ovary Anatomy 0.000 description 4
• 239000001301 oxygen Substances 0.000 description 4
• 239000000816 peptidomimetic Substances 0.000 description 4
• YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 4
• 108010049148 plastin Proteins 0.000 description 4
• 239000011148 porous material Substances 0.000 description 4
• 239000000843 powder Substances 0.000 description 4
• 238000012552 review Methods 0.000 description 4
• 239000011734 sodium Substances 0.000 description 4
• 239000002904 solvent Substances 0.000 description 4
• 241000894007 species Species 0.000 description 4
• 210000002784 stomach Anatomy 0.000 description 4
• 239000011232 storage material Substances 0.000 description 4
• 208000024891 symptom Diseases 0.000 description 4
• 239000003826 tablet Substances 0.000 description 4
• 229960004072 thrombin Drugs 0.000 description 4
• RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 4
• RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 4
• 210000003932 urinary bladder Anatomy 0.000 description 4
• 108090000195 villin Proteins 0.000 description 4
• 238000005406 washing Methods 0.000 description 4
• 238000001262 western blot Methods 0.000 description 4
• 230000003936 working memory Effects 0.000 description 4
• ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical class OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 3
• 241000894006 Bacteria Species 0.000 description 3
• 241000283690 Bos taurus Species 0.000 description 3
• 241000282472 Canis lupus familiaris Species 0.000 description 3
• 241000283707 Capra Species 0.000 description 3
• 229920000742 Cotton Polymers 0.000 description 3
• 241000283086 Equidae Species 0.000 description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
• 241000282326 Felis catus Species 0.000 description 3
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 3
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 3
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 3
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 3
• 102100034343 Integrase Human genes 0.000 description 3
• 101710203526 Integrase Proteins 0.000 description 3
• 108010063737 Myristoylated Alanine-Rich C Kinase Substrate Proteins 0.000 description 3
• 102000015695 Myristoylated Alanine-Rich C Kinase Substrate Human genes 0.000 description 3
• 108090000526 Papain Proteins 0.000 description 3
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 239000004365 Protease Substances 0.000 description 3
• 239000012722 SDS sample buffer Substances 0.000 description 3
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
• 238000010521 absorption reaction Methods 0.000 description 3
• 230000009471 action Effects 0.000 description 3
• 230000000890 antigenic effect Effects 0.000 description 3
• 239000002585 base Substances 0.000 description 3
• 230000004071 biological effect Effects 0.000 description 3
• 210000004369 blood Anatomy 0.000 description 3
• 239000008280 blood Substances 0.000 description 3
• 210000004556 brain Anatomy 0.000 description 3
• 239000011575 calcium Substances 0.000 description 3
• 210000000170 cell membrane Anatomy 0.000 description 3
• 210000003169 central nervous system Anatomy 0.000 description 3
• 238000002512 chemotherapy Methods 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 230000021615 conjugation Effects 0.000 description 3
• 238000012937 correction Methods 0.000 description 3
• 238000003235 crystal violet staining Methods 0.000 description 3
• 230000034994 death Effects 0.000 description 3
• 231100000517 death Toxicity 0.000 description 3
• 230000007547 defect Effects 0.000 description 3
• 238000011161 development Methods 0.000 description 3
• 230000018109 developmental process Effects 0.000 description 3
• 238000010586 diagram Methods 0.000 description 3
• 230000029087 digestion Effects 0.000 description 3
• 238000007876 drug discovery Methods 0.000 description 3
• 238000004520 electroporation Methods 0.000 description 3
• 230000009881 electrostatic interaction Effects 0.000 description 3
• 230000002255 enzymatic effect Effects 0.000 description 3
• 210000003238 esophagus Anatomy 0.000 description 3
• 239000000284 extract Substances 0.000 description 3
• 230000004907 flux Effects 0.000 description 3
• 230000002068 genetic effect Effects 0.000 description 3
• 235000003642 hunger Nutrition 0.000 description 3
• 210000004408 hybridoma Anatomy 0.000 description 3
• 229940027941 immunoglobulin g Drugs 0.000 description 3
• 230000001771 impaired effect Effects 0.000 description 3
• 238000002347 injection Methods 0.000 description 3
• 239000007924 injection Substances 0.000 description 3
• 230000003834 intracellular effect Effects 0.000 description 3
• 150000002632 lipids Chemical class 0.000 description 3
• 239000002502 liposome Substances 0.000 description 3
• 230000005381 magnetic domain Effects 0.000 description 3
• 239000003550 marker Substances 0.000 description 3
• 238000002844 melting Methods 0.000 description 3
• 230000008018 melting Effects 0.000 description 3
• 239000002105 nanoparticle Substances 0.000 description 3
• 230000013152 negative regulation of cell migration Effects 0.000 description 3
• 210000002241 neurite Anatomy 0.000 description 3
• 210000002569 neuron Anatomy 0.000 description 3
• 210000000496 pancreas Anatomy 0.000 description 3
• 239000013612 plasmid Substances 0.000 description 3
• 229920001223 polyethylene glycol Polymers 0.000 description 3
• 239000013641 positive control Substances 0.000 description 3
• 230000032361 posttranscriptional gene silencing Effects 0.000 description 3
• 230000035755 proliferation Effects 0.000 description 3
• 208000023958 prostate neoplasm Diseases 0.000 description 3
• 230000008521 reorganization Effects 0.000 description 3
• 230000035945 sensitivity Effects 0.000 description 3
• 229910052708 sodium Inorganic materials 0.000 description 3
• 230000002269 spontaneous effect Effects 0.000 description 3
• 239000012192 staining solution Substances 0.000 description 3
• 230000037351 starvation Effects 0.000 description 3
• 238000009120 supportive therapy Methods 0.000 description 3
• 230000001629 suppression Effects 0.000 description 3
• 239000004094 surface-active agent Substances 0.000 description 3
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
• 238000002054 transplantation Methods 0.000 description 3
• 230000004614 tumor growth Effects 0.000 description 3
• 210000003708 urethra Anatomy 0.000 description 3
• 239000003981 vehicle Substances 0.000 description 3
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 2
• RFLVMTUMFYRZCB-UHFFFAOYSA-N 1-methylguanine Chemical compound O=C1N(C)C(N)=NC2=C1N=CN2 RFLVMTUMFYRZCB-UHFFFAOYSA-N 0.000 description 2
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
• FZWGECJQACGGTI-UHFFFAOYSA-N 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one Chemical compound NC1=NC(O)=C2N(C)C=NC2=N1 FZWGECJQACGGTI-UHFFFAOYSA-N 0.000 description 2
• VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
• OVONXEQGWXGFJD-UHFFFAOYSA-N 4-sulfanylidene-1h-pyrimidin-2-one Chemical compound SC=1C=CNC(=O)N=1 OVONXEQGWXGFJD-UHFFFAOYSA-N 0.000 description 2
• OIVLITBTBDPEFK-UHFFFAOYSA-N 5,6-dihydrouracil Chemical compound O=C1CCNC(=O)N1 OIVLITBTBDPEFK-UHFFFAOYSA-N 0.000 description 2
• ZLAQATDNGLKIEV-UHFFFAOYSA-N 5-methyl-2-sulfanylidene-1h-pyrimidin-4-one Chemical compound CC1=CNC(=S)NC1=O ZLAQATDNGLKIEV-UHFFFAOYSA-N 0.000 description 2
• LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
• 108020005544 Antisense RNA Proteins 0.000 description 2
• 108091023037 Aptamer Proteins 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• 241000271566 Aves Species 0.000 description 2
• 241000167854 Bourreria succulenta Species 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• 108091026890 Coding region Proteins 0.000 description 2
• 108091033380 Coding strand Proteins 0.000 description 2
• 229920002261 Corn starch Polymers 0.000 description 2
• HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 2
• 102000053602 DNA Human genes 0.000 description 2
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
• 241000196324 Embryophyta Species 0.000 description 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
• 102000009300 Fascin-1 Human genes 0.000 description 2
• 108050000138 Fascin-1 Proteins 0.000 description 2
• 108050000118 Fascin-2 Proteins 0.000 description 2
• 102000009286 Fascin-2 Human genes 0.000 description 2
• 108050000117 Fascin-3 Proteins 0.000 description 2
• 102000009285 Fascin-3 Human genes 0.000 description 2
• 108090000331 Firefly luciferases Proteins 0.000 description 2
• 229930091371 Fructose Natural products 0.000 description 2
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
• 239000005715 Fructose Substances 0.000 description 2
• 208000002250 Hematologic Neoplasms Diseases 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
• 206010020751 Hypersensitivity Diseases 0.000 description 2
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
• 238000010824 Kaplan-Meier survival analysis Methods 0.000 description 2
• 206010024264 Lethargy Diseases 0.000 description 2
• WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
• 102000029749 Microtubule Human genes 0.000 description 2
• 108091022875 Microtubule Proteins 0.000 description 2
• HYVABZIGRDEKCD-UHFFFAOYSA-N N(6)-dimethylallyladenine Chemical compound CC(C)=CCNC1=NC=NC2=C1N=CN2 HYVABZIGRDEKCD-UHFFFAOYSA-N 0.000 description 2
• 229910002651 NO3 Inorganic materials 0.000 description 2
• 238000011789 NOD SCID mouse Methods 0.000 description 2
• 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 description 2
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
• 108091092724 Noncoding DNA Proteins 0.000 description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 description 2
• 108091034117 Oligonucleotide Proteins 0.000 description 2
• 229910019142 PO4 Inorganic materials 0.000 description 2
• 241001494479 Pecora Species 0.000 description 2
• 108091093037 Peptide nucleic acid Proteins 0.000 description 2
• KPKZJLCSROULON-QKGLWVMZSA-N Phalloidin Chemical compound N1C(=O)[C@@H]([C@@H](O)C)NC(=O)[C@H](C)NC(=O)[C@H](C[C@@](C)(O)CO)NC(=O)[C@H](C2)NC(=O)[C@H](C)NC(=O)[C@@H]3C[C@H](O)CN3C(=O)[C@@H]1CSC1=C2C2=CC=CC=C2N1 KPKZJLCSROULON-QKGLWVMZSA-N 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 241000276498 Pollachius virens Species 0.000 description 2
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
• 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 2
• 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 2
• 102000003923 Protein Kinase C Human genes 0.000 description 2
• 108090000315 Protein Kinase C Proteins 0.000 description 2
• 102000014450 RNA Polymerase III Human genes 0.000 description 2
• 108010078067 RNA Polymerase III Proteins 0.000 description 2
• 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 2
• 102000000574 RNA-Induced Silencing Complex Human genes 0.000 description 2
• 108010016790 RNA-Induced Silencing Complex Proteins 0.000 description 2
• 206010038111 Recurrent cancer Diseases 0.000 description 2
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 2
• 229920002684 Sepharose Polymers 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• 108010090804 Streptavidin Proteins 0.000 description 2
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
• 229930006000 Sucrose Natural products 0.000 description 2
• 241000282887 Suidae Species 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• 239000007983 Tris buffer Substances 0.000 description 2
• 239000013504 Triton X-100 Substances 0.000 description 2
• 229920004890 Triton X-100 Polymers 0.000 description 2
• 108090000848 Ubiquitin Proteins 0.000 description 2
• 102000044159 Ubiquitin Human genes 0.000 description 2
• 238000005411 Van der Waals force Methods 0.000 description 2
• 238000002441 X-ray diffraction Methods 0.000 description 2
• 241000021375 Xenogenes Species 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• 230000035508 accumulation Effects 0.000 description 2
• 238000009825 accumulation Methods 0.000 description 2
• 230000002378 acidificating effect Effects 0.000 description 2
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
• 239000002671 adjuvant Substances 0.000 description 2
• 235000010443 alginic acid Nutrition 0.000 description 2
• 229920000615 alginic acid Polymers 0.000 description 2
• 229910052783 alkali metal Inorganic materials 0.000 description 2
• 125000003342 alkenyl group Chemical group 0.000 description 2
• 230000007815 allergy Effects 0.000 description 2
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 2
• 150000001412 amines Chemical class 0.000 description 2
• 230000003321 amplification Effects 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 230000001093 anti-cancer Effects 0.000 description 2
• 230000002001 anti-metastasis Effects 0.000 description 2
• 210000000612 antigen-presenting cell Anatomy 0.000 description 2
• 239000002246 antineoplastic agent Substances 0.000 description 2
• 210000000436 anus Anatomy 0.000 description 2
• 208000006673 asthma Diseases 0.000 description 2
• 210000003719 b-lymphocyte Anatomy 0.000 description 2
• 230000008901 benefit Effects 0.000 description 2
• PNPBGYBHLCEVMK-UHFFFAOYSA-N benzylidene(dichloro)ruthenium;tricyclohexylphosphanium Chemical compound Cl[Ru](Cl)=CC1=CC=CC=C1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1 PNPBGYBHLCEVMK-UHFFFAOYSA-N 0.000 description 2
• 210000001124 body fluid Anatomy 0.000 description 2
• 210000000988 bone and bone Anatomy 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 125000004432 carbon atom Chemical group C* 0.000 description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
• 150000001735 carboxylic acids Chemical class 0.000 description 2
• 230000003197 catalytic effect Effects 0.000 description 2
• 239000013592 cell lysate Substances 0.000 description 2
• 230000004663 cell proliferation Effects 0.000 description 2
• 238000005119 centrifugation Methods 0.000 description 2
• 230000008859 change Effects 0.000 description 2
• 238000012512 characterization method Methods 0.000 description 2
• 238000006243 chemical reaction Methods 0.000 description 2
• 235000019693 cherries Nutrition 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• 210000000349 chromosome Anatomy 0.000 description 2
• 238000009643 clonogenic assay Methods 0.000 description 2
• 231100000096 clonogenic assay Toxicity 0.000 description 2
• 238000004590 computer program Methods 0.000 description 2
• 239000000039 congener Substances 0.000 description 2
• 238000010276 construction Methods 0.000 description 2
• 239000000356 contaminant Substances 0.000 description 2
• 238000007796 conventional method Methods 0.000 description 2
• 239000008120 corn starch Substances 0.000 description 2
• 230000002596 correlated effect Effects 0.000 description 2
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
• 210000004292 cytoskeleton Anatomy 0.000 description 2
• 238000009795 derivation Methods 0.000 description 2
• 235000014113 dietary fatty acids Nutrition 0.000 description 2
• MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 2
• 229940043264 dodecyl sulfate Drugs 0.000 description 2
• 210000000750 endocrine system Anatomy 0.000 description 2
• 210000002919 epithelial cell Anatomy 0.000 description 2
• 238000011156 evaluation Methods 0.000 description 2
• 238000010195 expression analysis Methods 0.000 description 2
• 229930195729 fatty acid Natural products 0.000 description 2
• 239000000194 fatty acid Substances 0.000 description 2
• 230000002349 favourable effect Effects 0.000 description 2
• 210000002950 fibroblast Anatomy 0.000 description 2
• 230000003325 follicular Effects 0.000 description 2
• 235000003599 food sweetener Nutrition 0.000 description 2
• 238000009472 formulation Methods 0.000 description 2
• 239000012458 free base Substances 0.000 description 2
• 230000030279 gene silencing Effects 0.000 description 2
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
• 239000011984 grubbs catalyst Substances 0.000 description 2
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
• 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 2
• 238000000703 high-speed centrifugation Methods 0.000 description 2
• 235000014304 histidine Nutrition 0.000 description 2
• 150000002411 histidines Chemical class 0.000 description 2
• 210000005260 human cell Anatomy 0.000 description 2
• 210000004293 human mammary gland Anatomy 0.000 description 2
• 230000007062 hydrolysis Effects 0.000 description 2
• 238000006460 hydrolysis reaction Methods 0.000 description 2
• OUUQCZGPVNCOIJ-UHFFFAOYSA-N hydroperoxyl Chemical compound O[O] OUUQCZGPVNCOIJ-UHFFFAOYSA-N 0.000 description 2
• FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
• 125000002883 imidazolyl group Chemical group 0.000 description 2
• 238000003018 immunoassay Methods 0.000 description 2
• 230000000415 inactivating effect Effects 0.000 description 2
• 230000006698 induction Effects 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 208000015181 infectious disease Diseases 0.000 description 2
• 239000004615 ingredient Substances 0.000 description 2
• 230000002452 interceptive effect Effects 0.000 description 2
• 238000001990 intravenous administration Methods 0.000 description 2
• 230000007794 irritation Effects 0.000 description 2
• 230000000302 ischemic effect Effects 0.000 description 2
• 238000002955 isolation Methods 0.000 description 2
• 150000002576 ketones Chemical class 0.000 description 2
• 210000003734 kidney Anatomy 0.000 description 2
• 230000002147 killing effect Effects 0.000 description 2
• 210000000265 leukocyte Anatomy 0.000 description 2
• 239000003446 ligand Substances 0.000 description 2
• 229910052744 lithium Inorganic materials 0.000 description 2
• 230000004807 localization Effects 0.000 description 2
• 229920002521 macromolecule Polymers 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
• 238000004949 mass spectrometry Methods 0.000 description 2
• 238000001819 mass spectrum Methods 0.000 description 2
• 239000011159 matrix material Substances 0.000 description 2
• 238000005259 measurement Methods 0.000 description 2
• 210000001370 mediastinum Anatomy 0.000 description 2
• 239000002207 metabolite Substances 0.000 description 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
• 244000005700 microbiome Species 0.000 description 2
• 238000000386 microscopy Methods 0.000 description 2
• 210000004688 microtubule Anatomy 0.000 description 2
• 230000003278 mimic effect Effects 0.000 description 2
• 238000003032 molecular docking Methods 0.000 description 2
• 210000000947 motile cell Anatomy 0.000 description 2
• 238000002703 mutagenesis Methods 0.000 description 2
• 231100000350 mutagenesis Toxicity 0.000 description 2
• 229930014626 natural product Natural products 0.000 description 2
• 239000013642 negative control Substances 0.000 description 2
• 238000003199 nucleic acid amplification method Methods 0.000 description 2
• 150000002894 organic compounds Chemical class 0.000 description 2
• 230000002611 ovarian Effects 0.000 description 2
• 229940055729 papain Drugs 0.000 description 2
• 235000019834 papain Nutrition 0.000 description 2
• 230000001575 pathological effect Effects 0.000 description 2
• 210000003899 penis Anatomy 0.000 description 2
• VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
• 239000000546 pharmaceutical excipient Substances 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
• 239000010452 phosphate Substances 0.000 description 2
• 230000026731 phosphorylation Effects 0.000 description 2
• 238000006366 phosphorylation reaction Methods 0.000 description 2
• 230000035790 physiological processes and functions Effects 0.000 description 2
• 239000006187 pill Substances 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• 239000011591 potassium Substances 0.000 description 2
• 230000003389 potentiating effect Effects 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• 230000002265 prevention Effects 0.000 description 2
• 230000001737 promoting effect Effects 0.000 description 2
• 210000002307 prostate Anatomy 0.000 description 2
• GRJJQCWNZGRKAU-UHFFFAOYSA-N pyridin-1-ium;fluoride Chemical compound F.C1=CC=NC=C1 GRJJQCWNZGRKAU-UHFFFAOYSA-N 0.000 description 2
• 150000003254 radicals Chemical class 0.000 description 2
• 238000003259 recombinant expression Methods 0.000 description 2
• 210000000664 rectum Anatomy 0.000 description 2
• 210000001350 reed-sternberg cell Anatomy 0.000 description 2
• 238000010992 reflux Methods 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 230000002441 reversible effect Effects 0.000 description 2
• 210000000813 small intestine Anatomy 0.000 description 2
• 239000007790 solid phase Substances 0.000 description 2
• 238000000527 sonication Methods 0.000 description 2
• 230000007480 spreading Effects 0.000 description 2
• 238000003892 spreading Methods 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• 125000001424 substituent group Chemical group 0.000 description 2
• KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
• 239000005720 sucrose Substances 0.000 description 2
• 235000000346 sugar Nutrition 0.000 description 2
• 239000000725 suspension Substances 0.000 description 2
• 239000003765 sweetening agent Substances 0.000 description 2
• 230000000946 synaptic effect Effects 0.000 description 2
• 239000006188 syrup Substances 0.000 description 2
• 235000020357 syrup Nutrition 0.000 description 2
• 102000013498 tau Proteins Human genes 0.000 description 2
• 210000001550 testis Anatomy 0.000 description 2
• HJUGFYREWKUQJT-UHFFFAOYSA-N tetrabromomethane Chemical compound BrC(Br)(Br)Br HJUGFYREWKUQJT-UHFFFAOYSA-N 0.000 description 2
• 210000003813 thumb Anatomy 0.000 description 2
• WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 2
• URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
• 229940035893 uracil Drugs 0.000 description 2
• 235000015112 vegetable and seed oil Nutrition 0.000 description 2
• 239000008158 vegetable oil Substances 0.000 description 2
• 210000003462 vein Anatomy 0.000 description 2
• 230000035899 viability Effects 0.000 description 2
• 238000011179 visual inspection Methods 0.000 description 2
• 239000012130 whole-cell lysate Substances 0.000 description 2
• LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical compound CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 1
• BPHPUYQFMNQIOC-MBOVONDJSA-N (2r,3r,4s,5r)-2-(hydroxymethyl)-6-propan-2-ylsulfanyloxane-3,4,5-triol Chemical compound CC(C)SC1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-MBOVONDJSA-N 0.000 description 1
• YDYLSLQZUZUZEN-UHFFFAOYSA-N 1-(benzenesulfonyl)oct-7-en-2-one Chemical compound C=CCCCCC(=O)CS(=O)(=O)C1=CC=CC=C1 YDYLSLQZUZUZEN-UHFFFAOYSA-N 0.000 description 1
• LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 1
• WLXGQMVCYPUOLM-UHFFFAOYSA-N 1-hydroxyethanesulfonic acid Chemical compound CC(O)S(O)(=O)=O WLXGQMVCYPUOLM-UHFFFAOYSA-N 0.000 description 1
• WJNGQIYEQLPJMN-IOSLPCCCSA-N 1-methylinosine Chemical compound C1=NC=2C(=O)N(C)C=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WJNGQIYEQLPJMN-IOSLPCCCSA-N 0.000 description 1
• HLYBTPMYFWWNJN-UHFFFAOYSA-N 2-(2,4-dioxo-1h-pyrimidin-5-yl)-2-hydroxyacetic acid Chemical compound OC(=O)C(O)C1=CNC(=O)NC1=O HLYBTPMYFWWNJN-UHFFFAOYSA-N 0.000 description 1
• SGAKLDIYNFXTCK-UHFFFAOYSA-N 2-[(2,4-dioxo-1h-pyrimidin-5-yl)methylamino]acetic acid Chemical compound OC(=O)CNCC1=CNC(=O)NC1=O SGAKLDIYNFXTCK-UHFFFAOYSA-N 0.000 description 1
• YSAJFXWTVFGPAX-UHFFFAOYSA-N 2-[(2,4-dioxo-1h-pyrimidin-5-yl)oxy]acetic acid Chemical compound OC(=O)COC1=CNC(=O)NC1=O YSAJFXWTVFGPAX-UHFFFAOYSA-N 0.000 description 1
• XMSMHKMPBNTBOD-UHFFFAOYSA-N 2-dimethylamino-6-hydroxypurine Chemical compound N1C(N(C)C)=NC(=O)C2=C1N=CN2 XMSMHKMPBNTBOD-UHFFFAOYSA-N 0.000 description 1
• RVHOBHMAPRVOLO-UHFFFAOYSA-N 2-ethylbutanedioic acid Chemical class CCC(C(O)=O)CC(O)=O RVHOBHMAPRVOLO-UHFFFAOYSA-N 0.000 description 1
• SMADWRYCYBUIKH-UHFFFAOYSA-N 2-methyl-7h-purin-6-amine Chemical compound CC1=NC(N)=C2NC=NC2=N1 SMADWRYCYBUIKH-UHFFFAOYSA-N 0.000 description 1
• 229940080296 2-naphthalenesulfonate Drugs 0.000 description 1
• FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• ZRPLANDPDWYOMZ-UHFFFAOYSA-N 3-cyclopentylpropionic acid Chemical compound OC(=O)CCC1CCCC1 ZRPLANDPDWYOMZ-UHFFFAOYSA-N 0.000 description 1
• KOLPWZCZXAMXKS-UHFFFAOYSA-N 3-methylcytosine Chemical compound CN1C(N)=CC=NC1=O KOLPWZCZXAMXKS-UHFFFAOYSA-N 0.000 description 1
• XMIIGOLPHOKFCH-UHFFFAOYSA-M 3-phenylpropionate Chemical compound [O-]C(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-M 0.000 description 1
• QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 1
• GJAKJCICANKRFD-UHFFFAOYSA-N 4-acetyl-4-amino-1,3-dihydropyrimidin-2-one Chemical compound CC(=O)C1(N)NC(=O)NC=C1 GJAKJCICANKRFD-UHFFFAOYSA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 229960000549 4-dimethylaminophenol Drugs 0.000 description 1
• MQJSSLBGAQJNER-UHFFFAOYSA-N 5-(methylaminomethyl)-1h-pyrimidine-2,4-dione Chemical compound CNCC1=CNC(=O)NC1=O MQJSSLBGAQJNER-UHFFFAOYSA-N 0.000 description 1
• WPYRHVXCOQLYLY-UHFFFAOYSA-N 5-[(methoxyamino)methyl]-2-sulfanylidene-1h-pyrimidin-4-one Chemical compound CONCC1=CNC(=S)NC1=O WPYRHVXCOQLYLY-UHFFFAOYSA-N 0.000 description 1
• LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical compound BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 description 1
• VKLFQTYNHLDMDP-PNHWDRBUSA-N 5-carboxymethylaminomethyl-2-thiouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=S)NC(=O)C(CNCC(O)=O)=C1 VKLFQTYNHLDMDP-PNHWDRBUSA-N 0.000 description 1
• ZFTBZKVVGZNMJR-UHFFFAOYSA-N 5-chlorouracil Chemical compound ClC1=CNC(=O)NC1=O ZFTBZKVVGZNMJR-UHFFFAOYSA-N 0.000 description 1
• KELXHQACBIUYSE-UHFFFAOYSA-N 5-methoxy-1h-pyrimidine-2,4-dione Chemical compound COC1=CNC(=O)NC1=O KELXHQACBIUYSE-UHFFFAOYSA-N 0.000 description 1
• LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 description 1
• DCPSTSVLRXOYGS-UHFFFAOYSA-N 6-amino-1h-pyrimidine-2-thione Chemical compound NC1=CC=NC(S)=N1 DCPSTSVLRXOYGS-UHFFFAOYSA-N 0.000 description 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
• MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical compound NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 description 1
• 208000030507 AIDS Diseases 0.000 description 1
• 206010000060 Abdominal distension Diseases 0.000 description 1
• 241000251468 Actinopterygii Species 0.000 description 1
• 206010000830 Acute leukaemia Diseases 0.000 description 1
• 208000006468 Adrenal Cortex Neoplasms Diseases 0.000 description 1
• 229920000936 Agarose Polymers 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
• 108010011485 Aspartame Proteins 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• 241000201370 Autographa californica nucleopolyhedrovirus Species 0.000 description 1
• 208000023275 Autoimmune disease Diseases 0.000 description 1
• 108090001008 Avidin Proteins 0.000 description 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
• 238000011725 BALB/c mouse Methods 0.000 description 1
• 102000004506 Blood Proteins Human genes 0.000 description 1
• 108010017384 Blood Proteins Proteins 0.000 description 1
• BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
• 238000007809 Boyden Chamber assay Methods 0.000 description 1
• 208000014644 Brain disease Diseases 0.000 description 1
• FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
• 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
• 102000014914 Carrier Proteins Human genes 0.000 description 1
• 238000007808 Cell invasion assay Methods 0.000 description 1
• 241000237074 Centris Species 0.000 description 1
• 229920001661 Chitosan Polymers 0.000 description 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• 108020004635 Complementary DNA Proteins 0.000 description 1
• 108091035707 Consensus sequence Proteins 0.000 description 1
• 238000011537 Coomassie blue staining Methods 0.000 description 1
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
• 241000699800 Cricetinae Species 0.000 description 1
• 239000004971 Cross linker Substances 0.000 description 1
• 108010069514 Cyclic Peptides Proteins 0.000 description 1
• 102000001189 Cyclic Peptides Human genes 0.000 description 1
• RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
• 108020001019 DNA Primers Proteins 0.000 description 1
• 239000003155 DNA primer Substances 0.000 description 1
• 230000004543 DNA replication Effects 0.000 description 1
• 206010012735 Diarrhoea Diseases 0.000 description 1
• 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
• SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 1
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
• 206010014759 Endometrial neoplasm Diseases 0.000 description 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
• 208000006168 Ewing Sarcoma Diseases 0.000 description 1
• 206010015866 Extravasation Diseases 0.000 description 1
• 108010077781 F-actin-binding proteins Proteins 0.000 description 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
• 230000005526 G1 to G0 transition Effects 0.000 description 1
• 241000287828 Gallus gallus Species 0.000 description 1
• 206010064571 Gene mutation Diseases 0.000 description 1
• 108700028146 Genetic Enhancer Elements Proteins 0.000 description 1
• SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
• 108010024636 Glutathione Proteins 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 241000238631 Hexapoda Species 0.000 description 1
• 102100034535 Histone H3.1 Human genes 0.000 description 1
• 101001030534 Homo sapiens Fascin-2 Proteins 0.000 description 1
• 101001030532 Homo sapiens Fascin-3 Proteins 0.000 description 1
• 101001067844 Homo sapiens Histone H3.1 Proteins 0.000 description 1
• 241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
• UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
• 102000012745 Immunoglobulin Subunits Human genes 0.000 description 1
• 108010079585 Immunoglobulin Subunits Proteins 0.000 description 1
• UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
• 229930010555 Inosine Natural products 0.000 description 1
• 108091092195 Intron Proteins 0.000 description 1
• 208000007766 Kaposi sarcoma Diseases 0.000 description 1
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 240000007472 Leucaena leucocephala Species 0.000 description 1
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
• 108060001084 Luciferase Proteins 0.000 description 1
• 239000005089 Luciferase Substances 0.000 description 1
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
• 238000007807 Matrigel invasion assay Methods 0.000 description 1
• 244000246386 Mentha pulegium Species 0.000 description 1
• 235000016257 Mentha pulegium Nutrition 0.000 description 1
• 235000004357 Mentha x piperita Nutrition 0.000 description 1
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
• 108060004795 Methyltransferase Proteins 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 208000034578 Multiple myelomas Diseases 0.000 description 1
• 241001529936 Murinae Species 0.000 description 1
• 108010021466 Mutant Proteins Proteins 0.000 description 1
• 102000008300 Mutant Proteins Human genes 0.000 description 1
• 241000238367 Mya arenaria Species 0.000 description 1
• SGSSKEDGVONRGC-UHFFFAOYSA-N N(2)-methylguanine Chemical compound O=C1NC(NC)=NC2=C1N=CN2 SGSSKEDGVONRGC-UHFFFAOYSA-N 0.000 description 1
• 241000244206 Nematoda Species 0.000 description 1
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
• 108700026244 Open Reading Frames Proteins 0.000 description 1
• 239000012124 Opti-MEM Substances 0.000 description 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 108010009711 Phalloidine Proteins 0.000 description 1
• 241000286209 Phasianidae Species 0.000 description 1
• 206010035226 Plasma cell myeloma Diseases 0.000 description 1
• 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
• 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 108010039918 Polylysine Proteins 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
• 102000007327 Protamines Human genes 0.000 description 1
• 108010007568 Protamines Proteins 0.000 description 1
• 108010029485 Protein Isoforms Proteins 0.000 description 1
• 102000001708 Protein Isoforms Human genes 0.000 description 1
• 108010076504 Protein Sorting Signals Proteins 0.000 description 1
• 101710150114 Protein rep Proteins 0.000 description 1
• 239000012980 RPMI-1640 medium Substances 0.000 description 1
• 108020005091 Replication Origin Proteins 0.000 description 1
• 101710088839 Replication initiation protein Proteins 0.000 description 1
• 108700008625 Reporter Genes Proteins 0.000 description 1
• 201000000582 Retinoblastoma Diseases 0.000 description 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
• 102000003661 Ribonuclease III Human genes 0.000 description 1
• 108010057163 Ribonuclease III Proteins 0.000 description 1
• 102000006382 Ribonucleases Human genes 0.000 description 1
• 108010083644 Ribonucleases Proteins 0.000 description 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
• 229920001800 Shellac Polymers 0.000 description 1
• XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
• BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
• 241000700584 Simplexvirus Species 0.000 description 1
• 108020004682 Single-Stranded DNA Proteins 0.000 description 1
• 241000187747 Streptomyces Species 0.000 description 1
• 238000000692 Student's t-test Methods 0.000 description 1
• 239000012505 Superdex™ Substances 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
• 102000006601 Thymidine Kinase Human genes 0.000 description 1
• 108020004440 Thymidine kinase Proteins 0.000 description 1
• 102100034838 Thymidine kinase, cytosolic Human genes 0.000 description 1
• 208000000728 Thymus Neoplasms Diseases 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• 102000004338 Transferrin Human genes 0.000 description 1
• 108090000901 Transferrin Proteins 0.000 description 1
• 108700019146 Transgenes Proteins 0.000 description 1
• 206010064390 Tumour invasion Diseases 0.000 description 1
• 206010054094 Tumour necrosis Diseases 0.000 description 1
• 206010050283 Tumour ulceration Diseases 0.000 description 1
• 208000003443 Unconsciousness Diseases 0.000 description 1
• COQLPRJCUIATTQ-UHFFFAOYSA-N Uranyl acetate Chemical compound O.O.O=[U]=O.CC(O)=O.CC(O)=O COQLPRJCUIATTQ-UHFFFAOYSA-N 0.000 description 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 108020005202 Viral DNA Proteins 0.000 description 1
• 206010047700 Vomiting Diseases 0.000 description 1
• 239000002250 absorbent Substances 0.000 description 1
• 230000002745 absorbent Effects 0.000 description 1
• 150000001242 acetic acid derivatives Chemical class 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
• 239000008186 active pharmaceutical agent Substances 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 230000010933 acylation Effects 0.000 description 1
• 238000005917 acylation reaction Methods 0.000 description 1
• 229960000643 adenine Drugs 0.000 description 1
• 229960005305 adenosine Drugs 0.000 description 1
• WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
• 239000000443 aerosol Substances 0.000 description 1
• 238000001042 affinity chromatography Methods 0.000 description 1
• 230000009824 affinity maturation Effects 0.000 description 1
• 239000011543 agarose gel Substances 0.000 description 1
• 150000001298 alcohols Chemical class 0.000 description 1
• 229940072056 alginate Drugs 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
• 239000003513 alkali Substances 0.000 description 1
• 150000001340 alkali metals Chemical class 0.000 description 1
• 150000001342 alkaline earth metals Chemical class 0.000 description 1
• 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
• 150000008052 alkyl sulfonates Chemical class 0.000 description 1
• 125000000304 alkynyl group Chemical group 0.000 description 1
• AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
• PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 230000002547 anomalous effect Effects 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 210000000628 antibody-producing cell Anatomy 0.000 description 1
• 239000003429 antifungal agent Substances 0.000 description 1
• 229940121375 antifungal agent Drugs 0.000 description 1
• 102000025171 antigen binding proteins Human genes 0.000 description 1
• 108091000831 antigen binding proteins Proteins 0.000 description 1
• 239000004599 antimicrobial Substances 0.000 description 1
• 230000006907 apoptotic process Effects 0.000 description 1
• 230000004596 appetite loss Effects 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 229940072107 ascorbate Drugs 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
• 239000000605 aspartame Substances 0.000 description 1
• 229960003438 aspartame Drugs 0.000 description 1
• 235000010357 aspartame Nutrition 0.000 description 1
• 229940009098 aspartate Drugs 0.000 description 1
• 108010045569 atelocollagen Proteins 0.000 description 1
• 150000007514 bases Chemical class 0.000 description 1
• 230000006399 behavior Effects 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• 229940077388 benzenesulfonate Drugs 0.000 description 1
• SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
• 229940050390 benzoate Drugs 0.000 description 1
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
• XMIIGOLPHOKFCH-UHFFFAOYSA-N beta-phenylpropanoic acid Natural products OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 108091008324 binding proteins Proteins 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 150000001615 biotins Chemical class 0.000 description 1
• 208000024330 bloating Diseases 0.000 description 1
• 230000036765 blood level Effects 0.000 description 1
• 239000010839 body fluid Substances 0.000 description 1
• 108010006025 bovine growth hormone Proteins 0.000 description 1
• 229940098773 bovine serum albumin Drugs 0.000 description 1
• 201000008275 breast carcinoma Diseases 0.000 description 1
• 125000001246 bromo group Chemical group Br* 0.000 description 1
• 239000006189 buccal tablet Substances 0.000 description 1
• 239000007975 buffered saline Substances 0.000 description 1
• 150000004648 butanoic acid derivatives Chemical class 0.000 description 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 238000010804 cDNA synthesis Methods 0.000 description 1
• 150000001669 calcium Chemical class 0.000 description 1
• FATUQANACHZLRT-KMRXSBRUSA-L calcium glucoheptonate Chemical compound [Ca+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O FATUQANACHZLRT-KMRXSBRUSA-L 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 238000004364 calculation method Methods 0.000 description 1
• MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
• 230000009400 cancer invasion Effects 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 description 1
• 150000007942 carboxylates Chemical class 0.000 description 1
• 208000002458 carcinoid tumor Diseases 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 210000005056 cell body Anatomy 0.000 description 1
• 230000024245 cell differentiation Effects 0.000 description 1
• 230000003915 cell function Effects 0.000 description 1
• 230000033077 cellular process Effects 0.000 description 1
• 230000007541 cellular toxicity Effects 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 235000010980 cellulose Nutrition 0.000 description 1
• 150000005829 chemical entities Chemical class 0.000 description 1
• 239000003638 chemical reducing agent Substances 0.000 description 1
• 239000002975 chemoattractant Substances 0.000 description 1
• 239000007958 cherry flavor Substances 0.000 description 1
• 235000013330 chicken meat Nutrition 0.000 description 1
• 201000002797 childhood leukemia Diseases 0.000 description 1
• 125000001309 chloro group Chemical group Cl* 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• 238000013375 chromatographic separation Methods 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 208000024207 chronic leukemia Diseases 0.000 description 1
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
• 239000004927 clay Substances 0.000 description 1
• 238000012875 competitive assay Methods 0.000 description 1
• 230000002860 competitive effect Effects 0.000 description 1
• 239000003184 complementary RNA Substances 0.000 description 1
• 238000000205 computational method Methods 0.000 description 1
• 230000008602 contraction Effects 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 229910052802 copper Inorganic materials 0.000 description 1
• 239000010949 copper Substances 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 210000004748 cultured cell Anatomy 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
• 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 description 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
• 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
• 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 description 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
• 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 1
• 235000018417 cysteine Nutrition 0.000 description 1
• 150000001945 cysteines Chemical class 0.000 description 1
• 229940104302 cytosine Drugs 0.000 description 1
• 230000003436 cytoskeletal effect Effects 0.000 description 1
• 229940127089 cytotoxic agent Drugs 0.000 description 1
• 230000007123 defense Effects 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 239000003405 delayed action preparation Substances 0.000 description 1
• 230000002939 deleterious effect Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 238000002716 delivery method Methods 0.000 description 1
• NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
• 229940038472 dicalcium phosphate Drugs 0.000 description 1
• 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
• 235000005911 diet Nutrition 0.000 description 1
• 230000037213 diet Effects 0.000 description 1
• MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
• 230000009274 differential gene expression Effects 0.000 description 1
• 238000009792 diffusion process Methods 0.000 description 1
• QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 1
• SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 1
• UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• MKRTXPORKIRPDG-UHFFFAOYSA-N diphenylphosphoryl azide Chemical compound C=1C=CC=CC=1P(=O)(N=[N+]=[N-])C1=CC=CC=C1 MKRTXPORKIRPDG-UHFFFAOYSA-N 0.000 description 1
• 239000002612 dispersion medium Substances 0.000 description 1
• POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
• 229940000406 drug candidate Drugs 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 238000000635 electron micrograph Methods 0.000 description 1
• 230000010102 embolization Effects 0.000 description 1
• 238000005538 encapsulation Methods 0.000 description 1
• 230000012202 endocytosis Effects 0.000 description 1
• RDYMFSUJUZBWLH-UHFFFAOYSA-N endosulfan Chemical compound C12COS(=O)OCC2C2(Cl)C(Cl)=C(Cl)C1(Cl)C2(Cl)Cl RDYMFSUJUZBWLH-UHFFFAOYSA-N 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 108010048367 enhanced green fluorescent protein Proteins 0.000 description 1
• 230000029578 entry into host Effects 0.000 description 1
• 239000002532 enzyme inhibitor Substances 0.000 description 1
• YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
• 125000004185 ester group Chemical group 0.000 description 1
• CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
• 238000013213 extrapolation Methods 0.000 description 1
• 230000036251 extravasation Effects 0.000 description 1
• 210000003195 fascia Anatomy 0.000 description 1
• 150000004665 fatty acids Chemical class 0.000 description 1
• 150000002191 fatty alcohols Chemical class 0.000 description 1
• 239000012894 fetal calf serum Substances 0.000 description 1
• 230000002374 filopodial effect Effects 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
• 239000007850 fluorescent dye Substances 0.000 description 1
• 125000001153 fluoro group Chemical group F* 0.000 description 1
• 229960002949 fluorouracil Drugs 0.000 description 1
• 210000000285 follicular dendritic cell Anatomy 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 150000004675 formic acid derivatives Chemical class 0.000 description 1
• 239000003205 fragrance Substances 0.000 description 1
• 238000004108 freeze drying Methods 0.000 description 1
• 239000007903 gelatin capsule Substances 0.000 description 1
• 238000002523 gelfiltration Methods 0.000 description 1
• 238000012226 gene silencing method Methods 0.000 description 1
• 238000001415 gene therapy Methods 0.000 description 1
• 238000012252 genetic analysis Methods 0.000 description 1
• 238000010448 genetic screening Methods 0.000 description 1
• 238000009650 gentamicin protection assay Methods 0.000 description 1
• 201000007116 gestational trophoblastic neoplasm Diseases 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 229940050410 gluconate Drugs 0.000 description 1
• 229960003180 glutathione Drugs 0.000 description 1
• 125000005908 glyceryl ester group Chemical group 0.000 description 1
• 239000001087 glyceryl triacetate Substances 0.000 description 1
• 235000013773 glyceryl triacetate Nutrition 0.000 description 1
• 150000002334 glycols Chemical class 0.000 description 1
• 230000007773 growth pattern Effects 0.000 description 1
• ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
• 150000004820 halides Chemical class 0.000 description 1
• 238000003306 harvesting Methods 0.000 description 1
• 201000010536 head and neck cancer Diseases 0.000 description 1
• 208000014829 head and neck neoplasm Diseases 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 208000006359 hepatoblastoma Diseases 0.000 description 1
• OSCNKYWIVFHQMF-UHFFFAOYSA-N hept-6-enoyl chloride Chemical compound ClC(=O)CCCCC=C OSCNKYWIVFHQMF-UHFFFAOYSA-N 0.000 description 1
• MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 1
• IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
• FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
• 238000013537 high throughput screening Methods 0.000 description 1
• 238000000265 homogenisation Methods 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 235000001050 hortel pimenta Nutrition 0.000 description 1
• XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
• ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
• 230000002209 hydrophobic effect Effects 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
• 208000013403 hyperactivity Diseases 0.000 description 1
• 210000002865 immune cell Anatomy 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000000984 immunochemical effect Effects 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 230000001976 improved effect Effects 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 239000003701 inert diluent Substances 0.000 description 1
• 238000002329 infrared spectrum Methods 0.000 description 1
• 239000007972 injectable composition Substances 0.000 description 1
• 229910052500 inorganic mineral Inorganic materials 0.000 description 1
• 229960003786 inosine Drugs 0.000 description 1
• 210000005133 interdigitating dendritic cell Anatomy 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 230000002601 intratumoral effect Effects 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 230000009545 invasion Effects 0.000 description 1
• 238000011835 investigation Methods 0.000 description 1
• 125000002346 iodo group Chemical group I* 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 238000004255 ion exchange chromatography Methods 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 208000037906 ischaemic injury Diseases 0.000 description 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 239000007951 isotonicity adjuster Substances 0.000 description 1
• 238000005304 joining Methods 0.000 description 1
• 125000000468 ketone group Chemical group 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 101150066555 lacZ gene Proteins 0.000 description 1
• 229940001447 lactate Drugs 0.000 description 1
• 229940099584 lactobionate Drugs 0.000 description 1
• JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 229940070765 laurate Drugs 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
• 238000001638 lipofection Methods 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 208000014018 liver neoplasm Diseases 0.000 description 1
• 244000144972 livestock Species 0.000 description 1
• 230000033001 locomotion Effects 0.000 description 1
• 235000021266 loss of appetite Nutrition 0.000 description 1
• 208000019017 loss of appetite Diseases 0.000 description 1
• 239000006210 lotion Substances 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 208000037841 lung tumor Diseases 0.000 description 1
• 230000000527 lymphocytic effect Effects 0.000 description 1
• 239000006166 lysate Substances 0.000 description 1
• 239000012139 lysis buffer Substances 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 159000000003 magnesium salts Chemical class 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 229940049920 malate Drugs 0.000 description 1
• 239000011976 maleic acid Substances 0.000 description 1
• BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
• 238000007726 management method Methods 0.000 description 1
• 108010082117 matrigel Proteins 0.000 description 1
• 238000010297 mechanical methods and process Methods 0.000 description 1
• 230000005226 mechanical processes and functions Effects 0.000 description 1
• 230000002503 metabolic effect Effects 0.000 description 1
• 229910052751 metal Inorganic materials 0.000 description 1
• 239000002184 metal Substances 0.000 description 1
• 238000003358 metastasis assay Methods 0.000 description 1
• 150000004702 methyl esters Chemical class 0.000 description 1
• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
• OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 238000000520 microinjection Methods 0.000 description 1
• 239000011707 mineral Substances 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 239000007758 minimum essential medium Substances 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 239000003607 modifier Substances 0.000 description 1
• 238000010369 molecular cloning Methods 0.000 description 1
• 238000000329 molecular dynamics simulation Methods 0.000 description 1
• 230000004001 molecular interaction Effects 0.000 description 1
• 238000000324 molecular mechanic Methods 0.000 description 1
• 238000000302 molecular modelling Methods 0.000 description 1
• 239000003068 molecular probe Substances 0.000 description 1
• 239000000178 monomer Substances 0.000 description 1
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
• 210000004897 n-terminal region Anatomy 0.000 description 1
• KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• 210000000440 neutrophil Anatomy 0.000 description 1
• 235000001968 nicotinic acid Nutrition 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
• 230000009871 nonspecific binding Effects 0.000 description 1
• 238000011330 nucleic acid test Methods 0.000 description 1
• 230000001293 nucleolytic effect Effects 0.000 description 1
• 235000015097 nutrients Nutrition 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 229940049964 oleate Drugs 0.000 description 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
• 230000034004 oogenesis Effects 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 239000007968 orange flavor Substances 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 230000001151 other effect Effects 0.000 description 1
• 229940043515 other immunoglobulins in atc Drugs 0.000 description 1
• 235000006408 oxalic acid Nutrition 0.000 description 1
• 238000004806 packaging method and process Methods 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 239000006072 paste Substances 0.000 description 1
• 201000009612 pediatric lymphoma Diseases 0.000 description 1
• JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
• 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
• JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
• 238000002823 phage display Methods 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 239000012071 phase Substances 0.000 description 1
• 229960003742 phenol Drugs 0.000 description 1
• 230000010399 physical interaction Effects 0.000 description 1
• 229940075930 picrate Drugs 0.000 description 1
• OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
• 229950010765 pivalate Drugs 0.000 description 1
• IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
• 208000010626 plasma cell neoplasm Diseases 0.000 description 1
• 230000036470 plasma concentration Effects 0.000 description 1
• 230000010287 polarization Effects 0.000 description 1
• 229920002401 polyacrylamide Polymers 0.000 description 1
• 230000008488 polyadenylation Effects 0.000 description 1
• 229920000656 polylysine Polymers 0.000 description 1
• 238000003752 polymerase chain reaction Methods 0.000 description 1
• 238000006116 polymerization reaction Methods 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 238000010837 poor prognosis Methods 0.000 description 1
• 159000000001 potassium salts Chemical class 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 238000011533 pre-incubation Methods 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 239000013615 primer Substances 0.000 description 1
• 238000004393 prognosis Methods 0.000 description 1
• 230000002062 proliferating effect Effects 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
• 201000001514 prostate carcinoma Diseases 0.000 description 1
• 229940048914 protamine Drugs 0.000 description 1
• 235000019419 proteases Nutrition 0.000 description 1
• 125000006239 protecting group Chemical group 0.000 description 1
• 239000011253 protective coating Substances 0.000 description 1
• 230000002797 proteolythic effect Effects 0.000 description 1
• 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
• 238000011002 quantification Methods 0.000 description 1
• 238000012207 quantitative assay Methods 0.000 description 1
• 125000001453 quaternary ammonium group Chemical group 0.000 description 1
• 230000005855 radiation Effects 0.000 description 1
• 238000003127 radioimmunoassay Methods 0.000 description 1
• 238000001959 radiotherapy Methods 0.000 description 1
• 238000010188 recombinant method Methods 0.000 description 1
• 230000006798 recombination Effects 0.000 description 1
• 238000005215 recombination Methods 0.000 description 1
• 238000001953 recrystallisation Methods 0.000 description 1
• 230000010076 replication Effects 0.000 description 1
• 230000003362 replicative effect Effects 0.000 description 1
• 229920003987 resole Polymers 0.000 description 1
• 230000004044 response Effects 0.000 description 1
• 230000021670 response to stimulus Effects 0.000 description 1
• 108091008146 restriction endonucleases Proteins 0.000 description 1
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
• 108700038288 rhodamine-phalloidin Proteins 0.000 description 1
• 150000003290 ribose derivatives Chemical class 0.000 description 1
• 238000007423 screening assay Methods 0.000 description 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 208000011581 secondary neoplasm Diseases 0.000 description 1
• 238000004062 sedimentation Methods 0.000 description 1
• 230000001235 sensitizing effect Effects 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 239000012679 serum free medium Substances 0.000 description 1
• ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
• 239000004208 shellac Substances 0.000 description 1
• 229940113147 shellac Drugs 0.000 description 1
• 235000013874 shellac Nutrition 0.000 description 1
• 229910052710 silicon Inorganic materials 0.000 description 1
• 239000010703 silicon Substances 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 229910052709 silver Inorganic materials 0.000 description 1
• 239000004332 silver Substances 0.000 description 1
• 238000002922 simulated annealing Methods 0.000 description 1
• 238000001542 size-exclusion chromatography Methods 0.000 description 1
• AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
• 239000000344 soap Substances 0.000 description 1
• 210000004872 soft tissue Anatomy 0.000 description 1
• 239000008247 solid mixture Substances 0.000 description 1
• 239000007892 solid unit dosage form Substances 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 125000006850 spacer group Chemical group 0.000 description 1
• 230000003595 spectral effect Effects 0.000 description 1
• 238000009987 spinning Methods 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 239000008174 sterile solution Substances 0.000 description 1
• 230000001954 sterilising effect Effects 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 238000002910 structure generation Methods 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
• 239000001384 succinic acid Substances 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 229920001059 synthetic polymer Polymers 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 229940095064 tartrate Drugs 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 239000002562 thickening agent Substances 0.000 description 1
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
• 229940033663 thimerosal Drugs 0.000 description 1
• 125000003396 thiol group Chemical group [H]S* 0.000 description 1
• 150000003573 thiols Chemical class 0.000 description 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
• 108010036901 thymidine kinase 1 Proteins 0.000 description 1
• 229940113082 thymine Drugs 0.000 description 1
• 201000009377 thymus cancer Diseases 0.000 description 1
• 229960003087 tioguanine Drugs 0.000 description 1
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 231100000041 toxicology testing Toxicity 0.000 description 1
• 230000005030 transcription termination Effects 0.000 description 1
• 230000002103 transcriptional effect Effects 0.000 description 1
• 239000012581 transferrin Substances 0.000 description 1
• 230000009466 transformation Effects 0.000 description 1
• 230000001052 transient effect Effects 0.000 description 1
• 229960002622 triacetin Drugs 0.000 description 1
• 239000003656 tris buffered saline Substances 0.000 description 1
• 230000005740 tumor formation Effects 0.000 description 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
• ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
• 210000000626 ureter Anatomy 0.000 description 1
• 210000002700 urine Anatomy 0.000 description 1
• 238000001291 vacuum drying Methods 0.000 description 1
• NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical class CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
• 230000029812 viral genome replication Effects 0.000 description 1
• 230000003612 virological effect Effects 0.000 description 1
• 230000008673 vomiting Effects 0.000 description 1
• 235000012431 wafers Nutrition 0.000 description 1
• 239000003643 water by type Substances 0.000 description 1
• 239000001993 wax Substances 0.000 description 1
• 230000004580 weight loss Effects 0.000 description 1
• 239000009637 wintergreen oil Substances 0.000 description 1
• 229940075420 xanthine Drugs 0.000 description 1
• 210000005253 yeast cell Anatomy 0.000 description 1