JP2010535180A5 - - Google Patents
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- Publication number
- JP2010535180A5 JP2010535180A5 JP2010518711A JP2010518711A JP2010535180A5 JP 2010535180 A5 JP2010535180 A5 JP 2010535180A5 JP 2010518711 A JP2010518711 A JP 2010518711A JP 2010518711 A JP2010518711 A JP 2010518711A JP 2010535180 A5 JP2010535180 A5 JP 2010535180A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- benzodioxol
- formula
- meo
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 61
- 125000003118 aryl group Chemical group 0.000 claims description 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
- 125000003107 substituted aryl group Chemical group 0.000 claims description 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 2
- -1 1,3-benzodioxol-5-yl Chemical group 0.000 claims 44
- WZELXJBMMZFDDU-UHFFFAOYSA-N Imidazol-2-one Chemical class O=C1N=CC=N1 WZELXJBMMZFDDU-UHFFFAOYSA-N 0.000 claims 20
- UGWULZWUXSCWPX-UHFFFAOYSA-N 2-sulfanylideneimidazolidin-4-one Chemical class O=C1CNC(=S)N1 UGWULZWUXSCWPX-UHFFFAOYSA-N 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 5
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 238000003786 synthesis reaction Methods 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 150000002825 nitriles Chemical class 0.000 claims 3
- 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 2
- 206010044688 Trisomy 21 Diseases 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000005670 ethenylalkyl group Chemical group 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 229920002554 vinyl polymer Polymers 0.000 claims 2
- KEQGZUUPPQEDPF-UHFFFAOYSA-N 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione Chemical class CC1(C)N(Cl)C(=O)N(Cl)C1=O KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 claims 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000004705 aldimines Chemical class 0.000 claims 1
- 239000004327 boric acid Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- WVKIFIROCHIWAY-UHFFFAOYSA-N hydron;2-(methylamino)acetic acid;chloride Chemical compound Cl.CNCC(O)=O WVKIFIROCHIWAY-UHFFFAOYSA-N 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 0 CN(C(*)=NC1=C*)C1=O Chemical compound CN(C(*)=NC1=C*)C1=O 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0705632 | 2007-08-01 | ||
| FR0705632A FR2919608B1 (fr) | 2007-08-01 | 2007-08-01 | Derives d'imidazolones,procede de preparation et applications biologiques |
| PCT/FR2008/001152 WO2009050352A2 (fr) | 2007-08-01 | 2008-08-01 | Derives d'imidazolones, procede de preparation et applications biologiques |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535180A JP2010535180A (ja) | 2010-11-18 |
| JP2010535180A5 true JP2010535180A5 (enExample) | 2014-07-10 |
| JP5926885B2 JP5926885B2 (ja) | 2016-05-25 |
Family
ID=39323606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518711A Active JP5926885B2 (ja) | 2007-08-01 | 2008-08-01 | イミダゾロン誘導体、その調製方法およびその生物学的使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8563588B2 (enExample) |
| EP (1) | EP2185547B1 (enExample) |
| JP (1) | JP5926885B2 (enExample) |
| KR (1) | KR20100051698A (enExample) |
| CN (1) | CN101784542B (enExample) |
| BR (1) | BRPI0814457A2 (enExample) |
| CA (1) | CA2694377A1 (enExample) |
| ES (1) | ES2644087T3 (enExample) |
| FR (1) | FR2919608B1 (enExample) |
| MX (1) | MX2010001170A (enExample) |
| RU (1) | RU2491283C2 (enExample) |
| WO (1) | WO2009050352A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10316000B2 (en) | 2009-02-18 | 2019-06-11 | Cornell University | Coupled recognition/detection system for in vivo and in vitro use |
| EP2281824A1 (en) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders |
| US11453646B2 (en) | 2011-07-27 | 2022-09-27 | Cornell University | Methods for RNA detection and quantification |
| JP5910976B2 (ja) * | 2012-07-30 | 2016-04-27 | 国立大学法人京都大学 | 精神神経疾患又は悪性腫瘍に関する化合物及び医薬組成物 |
| FR3002044A1 (fr) * | 2013-02-08 | 2014-08-15 | Centre Nat Rech Scient | Marqueur dyrk1a pour la maladie d'alzheimer |
| CN106061258A (zh) * | 2013-08-29 | 2016-10-26 | 弗吉尼亚联邦大学 | 制造2‑卤代烟腈的方法 |
| US9664676B2 (en) | 2013-09-06 | 2017-05-30 | Cornell University | RNA sequences that induce fluorescence of small molecule fluorophores |
| CN104370891B (zh) * | 2014-10-17 | 2016-09-07 | 中国农业大学 | 一种5-(丁烯内酯-3-亚乙基)-2-氨基咪唑啉酮类化合物、制备方法及其应用 |
| RU2730550C1 (ru) * | 2019-05-15 | 2020-08-24 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Производное 2-селеноксо-тетрагидро-4н-имидазол-4-она, способ его получения и применения |
| WO2021114314A1 (en) * | 2019-12-14 | 2021-06-17 | Tongji University | Novel heterocyclic derivatives with cardiomyocyte proliferation activity for treatment of heart diseases |
| US20220378748A1 (en) * | 2019-12-14 | 2022-12-01 | Shanghai East Hospital (East Hospital, Tongji University School Of Medicine) | Use of Heterocyclic Derivatives with Cardiomyocyte Proliferation Activity for Treatment of Heart Diseases |
| WO2021133037A1 (ko) * | 2019-12-26 | 2021-07-01 | 연세대학교 산학협력단 | 피롤리딘 유도체 및 이를 포함하는 베타-아밀로이드 또는 타우 단백질 관련 질병의 예방 또는 치료용 약학 조성물 |
| EP3904354A1 (en) | 2020-04-30 | 2021-11-03 | Perha Pharmaceuticals | New imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4 |
| CN115515953A (zh) * | 2020-04-30 | 2022-12-23 | 珀哈制药公司 | 作为蛋白激酶特别是dyrk1a、clk1和/或clk4的抑制剂的新的咪唑啉酮衍生物 |
| EP4173674A1 (en) | 2021-10-26 | 2023-05-03 | Perha Pharmaceuticals | Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4 |
| EP4173675A1 (en) | 2021-10-26 | 2023-05-03 | Perha Pharmaceuticals | Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4 |
| EP4173673A1 (en) | 2021-10-26 | 2023-05-03 | Perha Pharmaceuticals | Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4 |
| WO2025069008A1 (en) | 2023-09-28 | 2025-04-03 | Graviton Bioscience Bv | Therapy for treating type 1 diabetes using rock2 and dyrk1 inhibitors |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1038050B (de) * | 1955-11-17 | 1958-09-04 | Farmaceutici Italia S A Soc | Verfahren zur Herstellung von 5-(3', 4'-Dioxybenzyliden)-Derivaten heterocyclischer Verbindungen |
| US4431656A (en) * | 1981-02-05 | 1984-02-14 | Kanegafuchi Chemical Industry Company Limited | 3,5-di-Tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient |
| GR79384B (enExample) * | 1982-08-20 | 1984-10-22 | Hoechst Uk Ltd | |
| IE940525L (en) * | 1988-05-25 | 1989-11-25 | Warner Lambert Co | Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents |
| DE69007413T2 (de) * | 1989-10-09 | 1994-07-21 | Toshiba Kawasaki Kk | Organisches Material für die nichtlineare Optik und nichtlineare optische Vorrichtung. |
| US5143928A (en) * | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
| US5362733A (en) * | 1990-04-27 | 1994-11-08 | Orion-Yhtyma Oy | Pharmacologically active catechol derivatives |
| JP3015702B2 (ja) * | 1995-02-21 | 2000-03-06 | 株式会社アラクス | イミダゾール誘導体及びそれらの薬剤として許容される酸付加塩及びその製造法並びにそれらを有効成分とする抗潰瘍剤 |
| US6218437B1 (en) * | 1996-09-30 | 2001-04-17 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
| PL187019B1 (pl) * | 1997-02-19 | 2004-04-30 | Univ Jagiellonski Collegium Me | Nowe związki, pochodne 5-arylideno-4-okso-2-imidazolidynoglicyny |
| EG21566A (en) * | 1999-09-21 | 2001-12-31 | Hosny Hamed Hoharam | Synthesis of 5-(4-dimethylaminobenzli-dene)-2-phenylhydrozino (1,3-h) imidazole-4-one (iii) |
| JP2006510661A (ja) * | 2002-12-06 | 2006-03-30 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | Ｐｉ３ｋの阻害剤としてのベンズオキサジン−３−オン類及びその誘導体 |
| FR2855755B1 (fr) * | 2003-06-05 | 2007-09-07 | Oreal | Utilisation d'au moins un filtre de la lumiere bleue pour preserve le capital de carotenoides endogenes de la peau; nouveaux filtres de la lumiere bleue; compositions cosmetiques |
| US8106214B2 (en) * | 2003-07-28 | 2012-01-31 | Merck Serono Sa | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors |
| EP1805174A1 (en) * | 2004-10-14 | 2007-07-11 | F.Hoffmann-La Roche Ag | 1,5-naphthyridine azolidinones having cdk1 antiproliferative activity |
| US20090299063A1 (en) * | 2005-03-29 | 2009-12-03 | Paul Shapiro | Inhibitors for Extracellular Signal-Regulated Kinase Docking Domains and Uses Therefor |
| US7304074B2 (en) * | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
| JP2007063444A (ja) * | 2005-08-31 | 2007-03-15 | Tdk Corp | 錯化合物及びこれを用いた光記録媒体 |
| US7371862B2 (en) * | 2005-11-11 | 2008-05-13 | Pfizer Italia S.R.L. | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| WO2007065261A1 (en) * | 2005-12-07 | 2007-06-14 | American Diagnostica Inc. | Plasminogen activator inhibitor-1 inhibitors |
-
2007
- 2007-08-01 FR FR0705632A patent/FR2919608B1/fr active Active
-
2008
- 2008-08-01 WO PCT/FR2008/001152 patent/WO2009050352A2/fr not_active Ceased
- 2008-08-01 MX MX2010001170A patent/MX2010001170A/es active IP Right Grant
- 2008-08-01 US US12/452,940 patent/US8563588B2/en not_active Expired - Fee Related
- 2008-08-01 ES ES08838929.1T patent/ES2644087T3/es active Active
- 2008-08-01 CN CN200880103961.8A patent/CN101784542B/zh active Active
- 2008-08-01 RU RU2010107262/04A patent/RU2491283C2/ru active
- 2008-08-01 BR BRPI0814457-5A2A patent/BRPI0814457A2/pt not_active IP Right Cessation
- 2008-08-01 JP JP2010518711A patent/JP5926885B2/ja active Active
- 2008-08-01 EP EP08838929.1A patent/EP2185547B1/fr active Active
- 2008-08-01 CA CA2694377A patent/CA2694377A1/fr not_active Abandoned
- 2008-08-01 KR KR1020107004568A patent/KR20100051698A/ko not_active Ceased
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