JP2019014758A5 - - Google Patents

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Publication number
JP2019014758A5
JP2019014758A5 JP2018206547A JP2018206547A JP2019014758A5 JP 2019014758 A5 JP2019014758 A5 JP 2019014758A5 JP 2018206547 A JP2018206547 A JP 2018206547A JP 2018206547 A JP2018206547 A JP 2018206547A JP 2019014758 A5 JP2019014758 A5 JP 2019014758A5
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JP
Japan
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composition
optionally substituted
cancer
dutpase
alkyl
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JP2018206547A
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English (en)
Japanese (ja)
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JP2019014758A (ja
JP6660993B2 (ja
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Publication of JP2019014758A5 publication Critical patent/JP2019014758A5/ja
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JP2018206547A 2013-01-07 2018-11-01 デオキシウリジントリホスファターゼ阻害剤 Active JP6660993B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361749791P 2013-01-07 2013-01-07
US61/749,791 2013-01-07
US201361874643P 2013-09-06 2013-09-06
US61/874,643 2013-09-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2015551794A Division JP6450323B2 (ja) 2013-01-07 2014-01-03 デオキシウリジントリホスファターゼ阻害剤

Publications (3)

Publication Number Publication Date
JP2019014758A JP2019014758A (ja) 2019-01-31
JP2019014758A5 true JP2019014758A5 (enExample) 2019-05-09
JP6660993B2 JP6660993B2 (ja) 2020-03-11

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ID=50030487

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JP2015551794A Active JP6450323B2 (ja) 2013-01-07 2014-01-03 デオキシウリジントリホスファターゼ阻害剤
JP2018206547A Active JP6660993B2 (ja) 2013-01-07 2018-11-01 デオキシウリジントリホスファターゼ阻害剤

Family Applications Before (1)

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JP2015551794A Active JP6450323B2 (ja) 2013-01-07 2014-01-03 デオキシウリジントリホスファターゼ阻害剤

Country Status (7)

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US (3) US9809571B2 (enExample)
EP (1) EP2941423B1 (enExample)
JP (2) JP6450323B2 (enExample)
CN (1) CN105189478B (enExample)
CA (1) CA2914178C (enExample)
IL (1) IL239827B (enExample)
WO (1) WO2014107622A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105189478B (zh) 2013-01-07 2019-10-22 南加州大学 脱氧尿苷三磷酸酶抑制剂
EP3089964B1 (en) * 2014-01-03 2021-02-24 University Of Southern California Heteroatom-containing deoxyuridine triphosphatase inhibitors
WO2017006283A1 (en) 2015-07-08 2017-01-12 Cv6 Therapeutics (Ni) Limited Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
WO2017006271A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
WO2017006270A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors
JP6836589B2 (ja) * 2015-07-08 2021-03-03 シーブイ6 セラピューティクス (エヌアイ) リミテッド ヒダントインを含むデオキシウリジントリホスファターゼ阻害剤
AU2017232906B2 (en) 2016-03-16 2022-03-31 H. Lee Moffitt Cancer Center & Research Institute, Inc. Small molecules against cereblon to enhance effector T cell function
WO2017210545A1 (en) 2016-06-02 2017-12-07 Cadent Therapeutics, Inc. Potassium channel modulators
US11168059B2 (en) 2016-11-23 2021-11-09 Cv6 Therapeutics (Ni) Limited Amino sulfonyl compounds
US11014924B2 (en) 2016-11-23 2021-05-25 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
US10829457B2 (en) 2016-11-23 2020-11-10 Cv6 Therapeutics (Ni) Limited Nitrogen ring linked deoxyuridine triphosphatase inhibitors
US10858344B2 (en) 2016-11-23 2020-12-08 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
WO2018098204A1 (en) * 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited 6-membered uracil isosteres
WO2018128720A1 (en) 2017-01-05 2018-07-12 Cv6 Therapeutics (Ni) Limited Uracil containing compounds
KR102664772B1 (ko) 2017-01-23 2024-05-10 노파르티스 아게 칼륨 채널 조절제
AU2019301679A1 (en) 2018-07-11 2021-01-28 H. Lee Moffitt Cancer Center And Research Institute, Inc. Dimeric immuno-modulatory compounds against cereblon-based mechanisms
AU2019366312B2 (en) 2018-10-22 2025-04-24 Novartis Ag Crystalline forms of potassium channel modulators
BR112022026247A2 (pt) 2020-06-26 2023-01-17 Cv6 Therapeutics Ni Ltd Método para aumentar a eficácia terapêutica de um agente de imunoterapia, método de tratamento de câncer e método de inibição do crescimento de uma célula de câncer
WO2022197978A1 (en) * 2021-03-17 2022-09-22 President And Fellows Of Harvard College Compositions and methods for modulating mitochondrial function and biogenesis

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4829785B1 (enExample) 1970-03-26 1973-09-13
BE787766A (fr) * 1971-08-21 1973-02-19 Merck Patent Gmbh Imides d'acide glutarique et leur procede de preparation
US4063019A (en) 1976-03-30 1977-12-13 E. R. Squibb & Sons, Inc. [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives
US4304715A (en) 1979-06-08 1981-12-08 Derek Hudson Enkephalin analogues
DE3027596A1 (de) 1980-07-21 1982-02-18 Bayer Ag, 5090 Leverkusen Triazolidin-3,5-dion-oxyalkylverbindungen und verfahren zu ihrer herstellung
JPS5839672A (ja) 1981-09-03 1983-03-08 Chugai Pharmaceut Co Ltd ウラシル誘導体
JPS60243017A (ja) 1984-05-16 1985-12-03 Kyowa Hakko Kogyo Co Ltd 抗けいれん組成物
JPH0674251B2 (ja) 1986-02-07 1994-09-21 全薬工業株式▲会▼社 ビス−ジオキソピペラジン誘導体
JPS63101361A (ja) * 1986-09-08 1988-05-06 ブリティッシュ・テクノロジー・グループ・リミテッド ジオキソピペリジン誘導体を含有する不安解消組成物
FR2644786B1 (fr) 1989-03-21 1993-12-31 Adir Cie Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
US5599796A (en) 1993-12-02 1997-02-04 Emory University Treatment of urogenital cancer with boron neutron capture therapy
CA2200964A1 (en) 1994-11-24 1996-05-30 Takashi Sohda Alpha-ketoamide derivatives as cathepsin l inhibitor
US5962246A (en) 1996-03-29 1999-10-05 The University Of Medicine And Dentistry Of New Jersey dUTPase, its isoforms, and diagnostic and other uses
JPH09286786A (ja) 1996-04-18 1997-11-04 Nippon Paper Ind Co Ltd ピリミジン誘導体及びその抗腫瘍剤としての用途
DE19756212A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
US6054470A (en) 1997-12-18 2000-04-25 Boehringer Ingelheim Pharmaceuticals, Inc. Src family SH2 domain inhibitors
CA2366264A1 (en) 1999-04-02 2000-10-12 Bristol-Myers Squibb Company Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase
DE10002509A1 (de) * 2000-01-21 2001-07-26 Gruenenthal Gmbh Substituierte Glutarimide
WO2002074750A1 (en) 2001-03-15 2002-09-26 Astrazeneca Ab Metalloproteinase inhibitors
JP2002284686A (ja) 2001-03-28 2002-10-03 Sankyo Co Ltd スルホンアミド化合物を含有する医薬組成物
JP2004527535A (ja) 2001-04-11 2004-09-09 クイーンズ ユニバーシティ アット キングストン 抗発作発生剤および/または抗癲癇誘発剤としてのピリミジン化合物
US6822097B1 (en) * 2002-02-07 2004-11-23 Amgen, Inc. Compounds and methods of uses
AU2003249812A1 (en) 2002-07-18 2004-02-09 Queen's University At Kingston Dihydrouracil compounds as anti-ictogenic or anti-epileptogenic agents
AU2003256655A1 (en) 2002-07-25 2004-02-16 Merck And Co., Inc. Therapeutic compounds for treating dyslipidemic conditions
GB0221246D0 (en) 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
GB0400290D0 (en) 2004-01-08 2004-02-11 Medivir Ab dUTPase inhibitors
EP1848433A2 (en) 2005-01-25 2007-10-31 Celgene Corporation Methods and compositions using 4-amino-2-(3-methyl-2,6-dioxopiperidin-3-yl)-isoindole-1-3-dione
WO2006135763A2 (en) 2005-06-09 2006-12-21 The Johns Hopkins University Inhibitors of dna repair enzymes and methods of use thereof
NZ573793A (en) 2006-07-24 2012-01-12 Korea Res Inst Chem Tech Hiv reverse transcriptase inhibitors
EP1939186A1 (en) 2006-12-22 2008-07-02 Sulfidris S.r.l. 5-Fluorouracil derivatives and their use for the treatment of cancer
WO2009074575A2 (en) 2007-12-10 2009-06-18 Novartis Ag Organic compounds
KR101384940B1 (ko) 2008-06-03 2014-04-11 다이호야쿠힌고교 가부시키가이샤 인간 데옥시우리딘 트리포스파타아제 저해 활성을 갖는 신규 우라실 화합물 또는 그 염
WO2010025308A2 (en) 2008-08-27 2010-03-04 Universtiy Of Southern California Inhibitors of dutpase
JP2011231015A (ja) 2008-08-29 2011-11-17 Taiho Yakuhin Kogyo Kk 含窒素複素環を有する新規ウラシル化合物又はその塩
EP2398822B1 (en) 2009-02-19 2013-01-02 Novo Nordisk A/S Modification of factor viii
CN102458393B (zh) 2009-06-25 2014-08-20 生物验证系统股份公司 治疗肺结核的组合物
JP2013032293A (ja) 2009-11-30 2013-02-14 Taiho Yakuhin Kogyo Kk ヒトdUTPase阻害活性を有する5−フルオロウラシル化合物又はその塩
TWI466870B (zh) 2009-11-30 2015-01-01 Taiho Pharmaceutical Co Ltd Anti - tumor efficacy enhancer
JP2013047189A (ja) 2009-12-25 2013-03-07 Kyorin Pharmaceutical Co Ltd 新規パラバン酸誘導体及びそれらを有効成分とする医薬
GB201020032D0 (en) * 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
EP2734517B1 (en) 2011-07-18 2017-08-30 Merck Patent GmbH Benzamides
AU2012337781B2 (en) 2011-11-15 2017-07-06 Takeda Pharmaceutical Company Limited Dihydroxy aromatic heterocyclic compound
CN105189478B (zh) 2013-01-07 2019-10-22 南加州大学 脱氧尿苷三磷酸酶抑制剂
EP3089964B1 (en) 2014-01-03 2021-02-24 University Of Southern California Heteroatom-containing deoxyuridine triphosphatase inhibitors
WO2015142001A2 (ko) 2014-03-21 2015-09-24 충남대학교산학협력단 강심 활성을 갖는 화합물 및 이를 함유하는 심부전 예방 또는 치료용 약학적 조성물
EP3290038A4 (en) 2015-04-30 2018-12-26 Taiho Pharmaceutical Co., Ltd. Agent for alleviating adverse reaction to antitumor drug
US10259792B2 (en) 2015-05-01 2019-04-16 Taiho Pharmaceutical Co., Ltd. Crystal of uracil compound
WO2017006271A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
JP6836589B2 (ja) 2015-07-08 2021-03-03 シーブイ6 セラピューティクス (エヌアイ) リミテッド ヒダントインを含むデオキシウリジントリホスファターゼ阻害剤
WO2017006270A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors
WO2017006283A1 (en) 2015-07-08 2017-01-12 Cv6 Therapeutics (Ni) Limited Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
WO2018098204A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited 6-membered uracil isosteres
US11014924B2 (en) 2016-11-23 2021-05-25 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
US11168059B2 (en) 2016-11-23 2021-11-09 Cv6 Therapeutics (Ni) Limited Amino sulfonyl compounds
US10858344B2 (en) 2016-11-23 2020-12-08 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
US10829457B2 (en) 2016-11-23 2020-11-10 Cv6 Therapeutics (Ni) Limited Nitrogen ring linked deoxyuridine triphosphatase inhibitors
WO2018128720A1 (en) 2017-01-05 2018-07-12 Cv6 Therapeutics (Ni) Limited Uracil containing compounds

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