JP2010535204A5 - - Google Patents
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- Publication number
- JP2010535204A5 JP2010535204A5 JP2010519261A JP2010519261A JP2010535204A5 JP 2010535204 A5 JP2010535204 A5 JP 2010535204A5 JP 2010519261 A JP2010519261 A JP 2010519261A JP 2010519261 A JP2010519261 A JP 2010519261A JP 2010535204 A5 JP2010535204 A5 JP 2010535204A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- aryl
- compound
- alkanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 119
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 77
- 125000003118 aryl group Chemical group 0.000 claims description 56
- 125000001072 heteroaryl group Chemical group 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 40
- 239000001257 hydrogen Substances 0.000 claims description 40
- 125000005862 (C1-C6)alkanoyl group Chemical group 0.000 claims description 37
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 31
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 30
- -1 pyrrolidino, piperidino, piperazino, morpholino, thiomorpholino Chemical group 0.000 claims description 29
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 26
- 229910052757 nitrogen Inorganic materials 0.000 claims description 26
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 26
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 23
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 20
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 20
- 229910052760 oxygen Inorganic materials 0.000 claims description 14
- 229910052717 sulfur Inorganic materials 0.000 claims description 14
- PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 125000001475 halogen functional group Chemical group 0.000 claims description 12
- 125000001424 substituent group Chemical group 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 8
- 125000004414 alkyl thio group Chemical group 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 4
- 206010000830 Acute leukaemia Diseases 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims description 4
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 201000010536 head and neck cancer Diseases 0.000 claims description 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 108091081406 G-quadruplex Proteins 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 3
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims description 2
- 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 claims description 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims description 2
- 125000005129 aryl carbonyl group Chemical group 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims description 2
- 150000002431 hydrogen Chemical group 0.000 claims description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000013160 medical therapy Methods 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000000069 prophylactic effect Effects 0.000 claims description 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 229910052721 tungsten Inorganic materials 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 7
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 9
- 125000000217 alkyl group Chemical group 0.000 description 9
- 125000001589 carboacyl group Chemical group 0.000 description 9
- 0 CCC(CC)C([C@@](*)NC(c1c[o]c(-c2c[o]c(-c3c[o]c(-c4c[o]c(C(*)NC(/C5=*\CCCCC6=N5)=O)n4)n3)n2)n1)=O)=NC6=*C Chemical compound CCC(CC)C([C@@](*)NC(c1c[o]c(-c2c[o]c(-c3c[o]c(-c4c[o]c(C(*)NC(/C5=*\CCCCC6=N5)=O)n4)n3)n2)n1)=O)=NC6=*C 0.000 description 7
- 238000000034 method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95364807P | 2007-08-02 | 2007-08-02 | |
| PCT/US2008/072025 WO2009018551A2 (en) | 2007-08-02 | 2008-08-01 | Therapeutic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010535204A JP2010535204A (ja) | 2010-11-18 |
| JP2010535204A5 true JP2010535204A5 (enExample) | 2012-09-13 |
Family
ID=40305296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010519261A Pending JP2010535204A (ja) | 2007-08-02 | 2008-08-01 | 治療用化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8993607B2 (enExample) |
| EP (1) | EP2185568A4 (enExample) |
| JP (1) | JP2010535204A (enExample) |
| MX (1) | MX2010001303A (enExample) |
| WO (1) | WO2009018551A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8093235B2 (en) | 2006-04-25 | 2012-01-10 | Rutgers, The State University Of New Jersey | Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA |
| JP5325882B2 (ja) | 2007-08-02 | 2013-10-23 | ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー | 治療用化合物 |
| MX2010001303A (es) | 2007-08-02 | 2010-09-07 | Univ Rutgers | Compuestos terapeuticos. |
| EP2496704A4 (en) * | 2009-11-05 | 2013-05-01 | Univ Rutgers | THERAPEUTIC COMPOUNDS |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2020017624A1 (ja) * | 2018-07-20 | 2020-01-23 | 国立大学法人東京農工大学 | 抗がん剤 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851524A (en) | 1976-09-24 | 1989-07-25 | Exxon Research And Engineering Company | Amine-treated thio-bis-(alkyl lactone acid) and thio-bis-(hydrocarbyl diacid) materials, additives for lubricating compositions |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5869650A (en) | 1996-06-21 | 1999-02-09 | Fox Chase Cancer Center | Dendroamide compounds and their use in chemosensitizing multidrug resistant cells |
| JPH11180997A (ja) | 1997-12-24 | 1999-07-06 | Yamanouchi Pharmaceut Co Ltd | 新規抗腫瘍化合物 |
| DE60111651T2 (de) | 2000-12-12 | 2006-05-18 | Sosei Co., Ltd. | Verfahren zur herstellung von substanz gm-95 |
| EP1602659A1 (en) | 2003-03-04 | 2005-12-07 | Sosei Co., Ltd. | Gm-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent |
| GB0314726D0 (en) * | 2003-06-24 | 2003-07-30 | Inst Biomar Sa | New cytotoxic depsipeptides |
| JP2006160723A (ja) * | 2004-11-10 | 2006-06-22 | Marine Biotechnol Inst Co Ltd | 抗腫瘍活性を有する化合物及びその製造方法 |
| JP4876220B2 (ja) | 2005-05-13 | 2012-02-15 | 国立大学法人東京農工大学 | テロメスタチン誘導体 |
| US8093235B2 (en) | 2006-04-25 | 2012-01-10 | Rutgers, The State University Of New Jersey | Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA |
| CA2665818A1 (en) | 2006-04-25 | 2007-11-08 | Rutgers, The State University Of New Jersey | Therapeutic compounds |
| MX2010001303A (es) | 2007-08-02 | 2010-09-07 | Univ Rutgers | Compuestos terapeuticos. |
| JP5325882B2 (ja) | 2007-08-02 | 2013-10-23 | ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー | 治療用化合物 |
| EP2186810A1 (en) | 2008-10-31 | 2010-05-19 | Institut Curie | Poly-heteroaryl derivatives for the treatment of cancer |
| EP2496704A4 (en) | 2009-11-05 | 2013-05-01 | Univ Rutgers | THERAPEUTIC COMPOUNDS |
-
2008
- 2008-08-01 MX MX2010001303A patent/MX2010001303A/es not_active Application Discontinuation
- 2008-08-01 EP EP08826736A patent/EP2185568A4/en not_active Withdrawn
- 2008-08-01 US US12/671,888 patent/US8993607B2/en not_active Expired - Fee Related
- 2008-08-01 WO PCT/US2008/072025 patent/WO2009018551A2/en not_active Ceased
- 2008-08-01 JP JP2010519261A patent/JP2010535204A/ja active Pending
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