FR2919608B1 - Derives d'imidazolones,procede de preparation et applications biologiques - Google Patents

Derives d'imidazolones,procede de preparation et applications biologiques

Info

Publication number
FR2919608B1
FR2919608B1 FR0705632A FR0705632A FR2919608B1 FR 2919608 B1 FR2919608 B1 FR 2919608B1 FR 0705632 A FR0705632 A FR 0705632A FR 0705632 A FR0705632 A FR 0705632A FR 2919608 B1 FR2919608 B1 FR 2919608B1
Authority
FR
France
Prior art keywords
imidazolon
derivatives
preparation
biological applications
biological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0705632A
Other languages
English (en)
French (fr)
Other versions
FR2919608A1 (fr
Inventor
Francois Carreaux
Jean Pierre Bazureau
Steven Renault
Laurent Meijer
Olivier Lozach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite De Rennes Fr
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite de Rennes 1
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0705632A priority Critical patent/FR2919608B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Rennes 1 filed Critical Centre National de la Recherche Scientifique CNRS
Priority to CN200880103961.8A priority patent/CN101784542B/zh
Priority to JP2010518711A priority patent/JP5926885B2/ja
Priority to RU2010107262/04A priority patent/RU2491283C2/ru
Priority to ES08838929.1T priority patent/ES2644087T3/es
Priority to US12/452,940 priority patent/US8563588B2/en
Priority to KR1020107004568A priority patent/KR20100051698A/ko
Priority to EP08838929.1A priority patent/EP2185547B1/fr
Priority to MX2010001170A priority patent/MX2010001170A/es
Priority to PCT/FR2008/001152 priority patent/WO2009050352A2/fr
Priority to CA2694377A priority patent/CA2694377A1/fr
Priority to BRPI0814457-5A2A priority patent/BRPI0814457A2/pt
Publication of FR2919608A1 publication Critical patent/FR2919608A1/fr
Application granted granted Critical
Publication of FR2919608B1 publication Critical patent/FR2919608B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR0705632A 2007-08-01 2007-08-01 Derives d'imidazolones,procede de preparation et applications biologiques Expired - Fee Related FR2919608B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR0705632A FR2919608B1 (fr) 2007-08-01 2007-08-01 Derives d'imidazolones,procede de preparation et applications biologiques
MX2010001170A MX2010001170A (es) 2007-08-01 2008-08-01 Derivados de imidazolona, metodo de preparacion de los mismos y uso biologico de los mismos.
RU2010107262/04A RU2491283C2 (ru) 2007-08-01 2008-08-01 Производные имидазолонов, способ получения и биологические применения
ES08838929.1T ES2644087T3 (es) 2007-08-01 2008-08-01 Derivados de imidazolonas, procedimiento de preparación y aplicaciones biológicas
US12/452,940 US8563588B2 (en) 2007-08-01 2008-08-01 Imidazolone derivatives, method for the preparation thereof and biological applications
KR1020107004568A KR20100051698A (ko) 2007-08-01 2008-08-01 이미다졸론 유도체, 그 제조 방법 및 그 생물학적 용도
CN200880103961.8A CN101784542B (zh) 2007-08-01 2008-08-01 咪唑酮衍生物、制备方法及生物用途
JP2010518711A JP5926885B2 (ja) 2007-08-01 2008-08-01 イミダゾロン誘導体、その調製方法およびその生物学的使用
PCT/FR2008/001152 WO2009050352A2 (fr) 2007-08-01 2008-08-01 Derives d'imidazolones, procede de preparation et applications biologiques
CA2694377A CA2694377A1 (fr) 2007-08-01 2008-08-01 Derives d'imidazolones, procede de preparation et applications biologiques
BRPI0814457-5A2A BRPI0814457A2 (pt) 2007-08-01 2008-08-01 Derivados de imidazolona, composições farmacêuticas, utilização de derivados de imidazolona, e, processo de síntese de derivados de imidazolona
EP08838929.1A EP2185547B1 (fr) 2007-08-01 2008-08-01 Derives d'imidazolones, procede de preparation et applications biologiques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0705632A FR2919608B1 (fr) 2007-08-01 2007-08-01 Derives d'imidazolones,procede de preparation et applications biologiques

Publications (2)

Publication Number Publication Date
FR2919608A1 FR2919608A1 (fr) 2009-02-06
FR2919608B1 true FR2919608B1 (fr) 2012-10-05

Family

ID=39323606

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0705632A Expired - Fee Related FR2919608B1 (fr) 2007-08-01 2007-08-01 Derives d'imidazolones,procede de preparation et applications biologiques

Country Status (12)

Country Link
US (1) US8563588B2 (enExample)
EP (1) EP2185547B1 (enExample)
JP (1) JP5926885B2 (enExample)
KR (1) KR20100051698A (enExample)
CN (1) CN101784542B (enExample)
BR (1) BRPI0814457A2 (enExample)
CA (1) CA2694377A1 (enExample)
ES (1) ES2644087T3 (enExample)
FR (1) FR2919608B1 (enExample)
MX (1) MX2010001170A (enExample)
RU (1) RU2491283C2 (enExample)
WO (1) WO2009050352A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2398775T3 (da) 2009-02-18 2019-06-03 Univ Cornell Koblet genkendelses-/detekteringssystem til anvendelse in vivo og in vitro
EP2281824A1 (en) 2009-08-07 2011-02-09 Noscira, S.A. Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders
US11453646B2 (en) 2011-07-27 2022-09-27 Cornell University Methods for RNA detection and quantification
WO2014021337A1 (ja) * 2012-07-30 2014-02-06 国立大学法人京都大学 精神神経疾患又は悪性腫瘍に関する化合物及び医薬組成物
FR3002044A1 (fr) * 2013-02-08 2014-08-15 Centre Nat Rech Scient Marqueur dyrk1a pour la maladie d'alzheimer
EP3043646A4 (en) * 2013-08-29 2017-05-17 D. Tyler Mcquade Methods of making 2-halonicotinonitriles
US9664676B2 (en) 2013-09-06 2017-05-30 Cornell University RNA sequences that induce fluorescence of small molecule fluorophores
CN104370891B (zh) * 2014-10-17 2016-09-07 中国农业大学 一种5-(丁烯内酯-3-亚乙基)-2-氨基咪唑啉酮类化合物、制备方法及其应用
RU2730550C1 (ru) * 2019-05-15 2020-08-24 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Производное 2-селеноксо-тетрагидро-4н-имидазол-4-она, способ его получения и применения
WO2021114314A1 (en) * 2019-12-14 2021-06-17 Tongji University Novel heterocyclic derivatives with cardiomyocyte proliferation activity for treatment of heart diseases
CN114502161B (zh) * 2019-12-14 2024-03-29 上海市东方医院（同济大学附属东方医院） 具有心肌细胞增殖活性的杂环衍生物在治疗心脏病中的用途
EP4083037A4 (en) * 2019-12-26 2024-01-24 Yonsei University, University-Industry Foundation(UIF). Pyrrolidine derivative, and pharmaceutical composition for preventing or treating beta-amyloid or tau protein-associated diseases containing same
CA3174844A1 (en) 2020-04-30 2021-11-04 Perha Pharmaceuticals New imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
EP3904354A1 (en) 2020-04-30 2021-11-03 Perha Pharmaceuticals New imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
EP4173675A1 (en) 2021-10-26 2023-05-03 Perha Pharmaceuticals Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
EP4173674A1 (en) 2021-10-26 2023-05-03 Perha Pharmaceuticals Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
EP4173673A1 (en) 2021-10-26 2023-05-03 Perha Pharmaceuticals Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
AU2024352423A1 (en) 2023-09-28 2026-05-14 Graviton Pharmaceuticals B.V. Therapy for treating type 1 diabetes using rock2 and dyrk1 inhibitors

Family Cites Families (20)

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DE1038050B (de) * 1955-11-17 1958-09-04 Farmaceutici Italia S A Soc Verfahren zur Herstellung von 5-(3', 4'-Dioxybenzyliden)-Derivaten heterocyclischer Verbindungen
US4431656A (en) * 1981-02-05 1984-02-14 Kanegafuchi Chemical Industry Company Limited 3,5-di-Tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient
EP0102026A3 (en) * 1982-08-20 1984-05-16 Hoechst Uk Limited Thiazole derivatives
IE940525L (en) * 1988-05-25 1989-11-25 Warner Lambert Co Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents
EP0422900B1 (en) * 1989-10-09 1994-03-16 Kabushiki Kaisha Toshiba Organic nonlinear optical material and nonlinear optical element
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
EP0526598B1 (en) * 1990-04-27 1996-12-18 Orion-Yhtymà„ Oy New pharmacologically active catechol derivatives
JP3015702B2 (ja) * 1995-02-21 2000-03-06 株式会社アラクス イミダゾール誘導体及びそれらの薬剤として許容される酸付加塩及びその製造法並びにそれらを有効成分とする抗潰瘍剤
US6218437B1 (en) * 1996-09-30 2001-04-17 The Regents Of The University Of California Treatment and prevention of hepatic disorders
PL187019B1 (pl) * 1997-02-19 2004-04-30 Univ Jagiellonski Collegium Me Nowe związki, pochodne 5-arylideno-4-okso-2-imidazolidynoglicyny
EG21566A (en) * 1999-09-21 2001-12-31 Hosny Hamed Hoharam Synthesis of 5-(4-dimethylaminobenzli-dene)-2-phenylhydrozino (1,3-h) imidazole-4-one (iii)
JP2006510661A (ja) * 2002-12-06 2006-03-30 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Ｐｉ３ｋの阻害剤としてのベンズオキサジン−３−オン類及びその誘導体
FR2855755B1 (fr) * 2003-06-05 2007-09-07 Oreal Utilisation d'au moins un filtre de la lumiere bleue pour preserve le capital de carotenoides endogenes de la peau; nouveaux filtres de la lumiere bleue; compositions cosmetiques
JP4908210B2 (ja) * 2003-07-28 2012-04-04 メルク セローノ ソシエテ アノニム Ｐｉ３キナーゼ阻害剤として使用するための２−イミノ−４−（チオ）オキソ−５−ポリシクロビニルアゾリン類
EP1805174A1 (en) * 2004-10-14 2007-07-11 F.Hoffmann-La Roche Ag 1,5-naphthyridine azolidinones having cdk1 antiproliferative activity
US20090299063A1 (en) * 2005-03-29 2009-12-03 Paul Shapiro Inhibitors for Extracellular Signal-Regulated Kinase Docking Domains and Uses Therefor
US7304074B2 (en) * 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
JP2007063444A (ja) * 2005-08-31 2007-03-15 Tdk Corp 錯化合物及びこれを用いた光記録媒体
US7371862B2 (en) * 2005-11-11 2008-05-13 Pfizer Italia S.R.L. Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
EP1960395A4 (en) * 2005-12-07 2009-12-02 American Diagnostica Inc INHIBITORS OF PLASMINOGENACTIVATORINHIBITOR-1

Also Published As

Publication number Publication date
JP2010535180A (ja) 2010-11-18
RU2010107262A (ru) 2011-09-10
FR2919608A1 (fr) 2009-02-06
CA2694377A1 (fr) 2009-04-23
KR20100051698A (ko) 2010-05-17
EP2185547B1 (fr) 2017-07-19
US20100216855A1 (en) 2010-08-26
MX2010001170A (es) 2010-06-25
WO2009050352A3 (fr) 2009-07-23
US8563588B2 (en) 2013-10-22
RU2491283C2 (ru) 2013-08-27
ES2644087T3 (es) 2017-11-27
WO2009050352A2 (fr) 2009-04-23
JP5926885B2 (ja) 2016-05-25
CN101784542B (zh) 2014-04-02
CN101784542A (zh) 2010-07-21
EP2185547A2 (fr) 2010-05-19
BRPI0814457A2 (pt) 2015-01-06

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