KR102382772B1 - 화학적으로 변형된 가이드 rna를 사용하는 고 특이성 게놈 편집 - Google Patents
화학적으로 변형된 가이드 rna를 사용하는 고 특이성 게놈 편집 Download PDFInfo
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| US201662347553P | 2016-06-08 | 2016-06-08 | |
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| US15/493,129 US10767175B2 (en) | 2016-06-08 | 2017-04-20 | High specificity genome editing using chemically modified guide RNAs |
| US15/493,129 | 2017-04-20 | ||
| PCT/US2017/036648 WO2017214460A1 (en) | 2016-06-08 | 2017-06-08 | High specificity genome editing using chemically modified guide rnas |
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| KR20190017022A KR20190017022A (ko) | 2019-02-19 |
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| WO2017136794A1 (en) | 2016-02-03 | 2017-08-10 | Massachusetts Institute Of Technology | Structure-guided chemical modification of guide rna and its applications |
| US10767175B2 (en) * | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| SG10202106058WA (en) | 2016-12-08 | 2021-07-29 | Intellia Therapeutics Inc | Modified guide rnas |
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| US20140273232A1 (en) | 2012-12-12 | 2014-09-18 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions for sequence manipulation |
| WO2015026885A1 (en) * | 2013-08-22 | 2015-02-26 | Pioneer Hi-Bred International, Inc. | Genome modification using guide polynucleotide/cas endonuclease systems and methods of use |
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| US20160040189A1 (en) | 2014-08-07 | 2016-02-11 | Agilent Technologies, Inc. | Cis-blocked guide rna |
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| US10767175B2 (en) | 2020-09-08 |
| CN109563514A (zh) | 2019-04-02 |
| US20170355985A1 (en) | 2017-12-14 |
| JP7431891B2 (ja) | 2024-02-15 |
| EP3469084A4 (en) | 2020-01-22 |
| US20200339980A1 (en) | 2020-10-29 |
| KR20190017022A (ko) | 2019-02-19 |
| JP2022137068A (ja) | 2022-09-21 |
| JP2019517268A (ja) | 2019-06-24 |
| AU2017277918A1 (en) | 2019-01-24 |
| EP3469084A1 (en) | 2019-04-17 |
| WO2017214460A1 (en) | 2017-12-14 |
| CN116676305A (zh) | 2023-09-01 |
| CN109563514B (zh) | 2023-03-10 |
| AU2017277918B2 (en) | 2023-06-29 |
| JP7093728B2 (ja) | 2022-06-30 |
| CA3026372A1 (en) | 2017-12-14 |
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