AU2017277918B2 - High specificity genome editing using chemically modified guide RNAs - Google Patents
High specificity genome editing using chemically modified guide RNAs Download PDFInfo
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- AU2017277918B2 AU2017277918B2 AU2017277918A AU2017277918A AU2017277918B2 AU 2017277918 B2 AU2017277918 B2 AU 2017277918B2 AU 2017277918 A AU2017277918 A AU 2017277918A AU 2017277918 A AU2017277918 A AU 2017277918A AU 2017277918 B2 AU2017277918 B2 AU 2017277918B2
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662347553P | 2016-06-08 | 2016-06-08 | |
| US62/347,553 | 2016-06-08 | ||
| US15/493,129 US10767175B2 (en) | 2016-06-08 | 2017-04-20 | High specificity genome editing using chemically modified guide RNAs |
| US15/493,129 | 2017-04-20 | ||
| PCT/US2017/036648 WO2017214460A1 (en) | 2016-06-08 | 2017-06-08 | High specificity genome editing using chemically modified guide rnas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017277918A1 AU2017277918A1 (en) | 2019-01-24 |
| AU2017277918B2 true AU2017277918B2 (en) | 2023-06-29 |
Family
ID=60573695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017277918A Active AU2017277918B2 (en) | 2016-06-08 | 2017-06-08 | High specificity genome editing using chemically modified guide RNAs |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10767175B2 (enExample) |
| EP (1) | EP3469084A4 (enExample) |
| JP (2) | JP7093728B2 (enExample) |
| KR (1) | KR102382772B1 (enExample) |
| CN (2) | CN109563514B (enExample) |
| AU (1) | AU2017277918B2 (enExample) |
| WO (1) | WO2017214460A1 (enExample) |
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| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| ES2810375T3 (es) | 2014-12-17 | 2021-03-08 | Proqr Therapeutics Ii Bv | Edición direccionada de ARN |
| KR102888521B1 (ko) | 2015-04-06 | 2025-11-19 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| WO2017053729A1 (en) | 2015-09-25 | 2017-03-30 | The Board Of Trustees Of The Leland Stanford Junior University | Nuclease-mediated genome editing of primary cells and enrichment thereof |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
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| SG11201906735RA (en) | 2017-01-23 | 2019-08-27 | Regeneron Pharma | Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof |
| IL268895B2 (en) | 2017-02-28 | 2025-05-01 | Vor Biopharma Inc | Compositions and methods for inhibition of lineage specific proteins |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
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| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| WO2018176009A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| JP2020516283A (ja) | 2017-04-11 | 2020-06-11 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | ヒドロキシステロイド(17−ベータ)デヒドロゲナーゼ(hsd17b)ファミリーのメンバーのモジュレーターの活性をスクリーニングするためのアッセイ |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
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| US11897920B2 (en) | 2017-08-04 | 2024-02-13 | Peking University | Tale RVD specifically recognizing DNA base modified by methylation and application thereof |
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| US20170355985A1 (en) | 2017-12-14 |
| WO2017214460A1 (en) | 2017-12-14 |
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