JP2017537626A5 - - Google Patents

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JP2017537626A5
JP2017537626A5 JP2017529610A JP2017529610A JP2017537626A5 JP 2017537626 A5 JP2017537626 A5 JP 2017537626A5 JP 2017529610 A JP2017529610 A JP 2017529610A JP 2017529610 A JP2017529610 A JP 2017529610A JP 2017537626 A5 JP2017537626 A5 JP 2017537626A5
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guide rna
synthetic guide
linkage
rna
sequence
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JP2017537626A (ja
JP7068821B2 (ja
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JP2017529610A 2014-12-03 2015-12-03 化学修飾を有するガイドrna Active JP7068821B2 (ja)

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JP2022020615A JP7579820B2 (ja) 2014-12-03 2022-02-14 化学修飾を有するガイドrna

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US201462087211P 2014-12-03 2014-12-03
US62/087,211 2014-12-03
US201562146189P 2015-04-10 2015-04-10
US62/146,189 2015-04-10
US201562256095P 2015-11-16 2015-11-16
US62/256,095 2015-11-16
PCT/US2015/000143 WO2016089433A1 (en) 2014-12-03 2015-12-03 Guide rna with chemical modifications

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JP2017537626A JP2017537626A (ja) 2017-12-21
JP2017537626A5 true JP2017537626A5 (enExample) 2019-01-17
JP7068821B2 JP7068821B2 (ja) 2022-05-17

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JP2022020615A Active JP7579820B2 (ja) 2014-12-03 2022-02-14 化学修飾を有するガイドrna

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US (5) US10900034B2 (enExample)
EP (2) EP4400584A3 (enExample)
JP (2) JP7068821B2 (enExample)
KR (2) KR102629128B1 (enExample)
CN (1) CN107250148B (enExample)
AU (1) AU2015355546B2 (enExample)
CA (1) CA2969619A1 (enExample)
WO (1) WO2016089433A1 (enExample)

Families Citing this family (191)

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KR102546296B1 (ko) 2014-10-31 2023-06-21 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도
US9816080B2 (en) 2014-10-31 2017-11-14 President And Fellows Of Harvard College Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
TWI716367B (zh) 2014-10-31 2021-01-21 麻省理工學院 用於常間回文重複序列叢集(crispr)之大量平行組合性基因學
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EP3390624A4 (en) 2015-12-18 2019-07-10 The Regents of The University of California Modified site-directed modifying polypeptides and methods of use thereof
EP3392337B1 (en) 2015-12-18 2024-03-06 Japan Science and Technology Agency Genetic modification non-human organism, egg cells, fertilized eggs, and method for modifying target genes
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