JP2017537626A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017537626A5 JP2017537626A5 JP2017529610A JP2017529610A JP2017537626A5 JP 2017537626 A5 JP2017537626 A5 JP 2017537626A5 JP 2017529610 A JP2017529610 A JP 2017529610A JP 2017529610 A JP2017529610 A JP 2017529610A JP 2017537626 A5 JP2017537626 A5 JP 2017537626A5
- Authority
- JP
- Japan
- Prior art keywords
- guide rna
- synthetic guide
- linkage
- rna
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022020615A JP7579820B2 (ja) | 2014-12-03 | 2022-02-14 | 化学修飾を有するガイドrna |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462087211P | 2014-12-03 | 2014-12-03 | |
| US62/087,211 | 2014-12-03 | ||
| US201562146189P | 2015-04-10 | 2015-04-10 | |
| US62/146,189 | 2015-04-10 | ||
| US201562256095P | 2015-11-16 | 2015-11-16 | |
| US62/256,095 | 2015-11-16 | ||
| PCT/US2015/000143 WO2016089433A1 (en) | 2014-12-03 | 2015-12-03 | Guide rna with chemical modifications |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022020615A Division JP7579820B2 (ja) | 2014-12-03 | 2022-02-14 | 化学修飾を有するガイドrna |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537626A JP2017537626A (ja) | 2017-12-21 |
| JP2017537626A5 true JP2017537626A5 (enExample) | 2019-01-17 |
| JP7068821B2 JP7068821B2 (ja) | 2022-05-17 |
Family
ID=56092183
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529610A Active JP7068821B2 (ja) | 2014-12-03 | 2015-12-03 | 化学修飾を有するガイドrna |
| JP2022020615A Active JP7579820B2 (ja) | 2014-12-03 | 2022-02-14 | 化学修飾を有するガイドrna |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022020615A Active JP7579820B2 (ja) | 2014-12-03 | 2022-02-14 | 化学修飾を有するガイドrna |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US10900034B2 (enExample) |
| EP (2) | EP4400584A3 (enExample) |
| JP (2) | JP7068821B2 (enExample) |
| KR (2) | KR102629128B1 (enExample) |
| CN (1) | CN107250148B (enExample) |
| AU (1) | AU2015355546B2 (enExample) |
| CA (1) | CA2969619A1 (enExample) |
| WO (1) | WO2016089433A1 (enExample) |
Families Citing this family (191)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| LT3105328T (lt) | 2014-02-11 | 2020-07-10 | The Regents Of The University Of Colorado, A Body Corporate | Daugiakomponentis genomo konstravimas, sudarantis sąlygas crispr |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CA2969619A1 (en) | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| AU2015367378A1 (en) | 2014-12-17 | 2017-06-15 | Proqr Therapeutics Ii B.V. | Targeted RNA editing |
| JP2017538427A (ja) | 2014-12-18 | 2017-12-28 | インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド | Crispr系組成物及び使用方法 |
| US12129471B2 (en) | 2015-02-23 | 2024-10-29 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of human genetic diseases including hemoglobinopathies |
| WO2016135558A2 (en) | 2015-02-23 | 2016-09-01 | Crispr Therapeutics Ag | Materials and methods for treatment of hemoglobinopathies |
| CN107787367B (zh) | 2015-04-06 | 2021-10-26 | 里兰斯坦福初级大学理事会 | 用于crispr/cas介导的基因调控的化学修饰的引导rna |
| JP2018519811A (ja) | 2015-06-29 | 2018-07-26 | アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. | 修飾crispr rna及び修飾単一crispr rnaならびにその使用 |
| US11279928B2 (en) | 2015-06-29 | 2022-03-22 | Massachusetts Institute Of Technology | Compositions comprising nucleic acids and methods of using the same |
| EP4339287A3 (en) | 2015-07-31 | 2024-05-22 | Regents Of The University Of Minnesota | Modified cells and methods of therapy |
| WO2017053729A1 (en) | 2015-09-25 | 2017-03-30 | The Board Of Trustees Of The Leland Stanford Junior University | Nuclease-mediated genome editing of primary cells and enrichment thereof |
| EP3159407A1 (en) * | 2015-10-23 | 2017-04-26 | Silence Therapeutics (London) Ltd | Guide rnas, methods and uses |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| EP3371306B8 (en) | 2015-11-04 | 2023-02-22 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of hemoglobinopathies |
| WO2017136794A1 (en) * | 2016-02-03 | 2017-08-10 | Massachusetts Institute Of Technology | Structure-guided chemical modification of guide rna and its applications |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| EP3475424A1 (en) | 2016-06-22 | 2019-05-01 | ProQR Therapeutics II B.V. | Single-stranded rna-editing oligonucleotides |
| CN109688820B (zh) | 2016-06-24 | 2023-01-10 | 科罗拉多州立大学董事会(法人团体) | 用于生成条形码化组合文库的方法 |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| US11352647B2 (en) | 2016-08-17 | 2022-06-07 | The Broad Institute, Inc. | Crispr enzymes and systems |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| WO2018041973A1 (en) | 2016-09-01 | 2018-03-08 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded rna-editing oligonucleotides |
| EP3516061A1 (en) | 2016-09-23 | 2019-07-31 | Synthena AG | Mixed tricyclo-dna, 2'-modified rna oligonucleotide compositions and uses thereof |
| CA3034931A1 (en) | 2016-09-23 | 2018-03-29 | Board Of Trustees Of Southern Illinois University | Tuning crispr/cas9 activity with chemically modified nucleotide substitutions |
| WO2018055577A1 (en) * | 2016-09-23 | 2018-03-29 | Synthena Ag | Mixed tricyclo-dna, 2'-modified rna oligonucleotide compositions and uses thereof |
| US10669539B2 (en) * | 2016-10-06 | 2020-06-02 | Pioneer Biolabs, Llc | Methods and compositions for generating CRISPR guide RNA libraries |
| WO2018068053A2 (en) | 2016-10-07 | 2018-04-12 | Integrated Dna Technologies, Inc. | S. pyogenes cas9 mutant genes and polypeptides encoded by same |
| US11242542B2 (en) | 2016-10-07 | 2022-02-08 | Integrated Dna Technologies, Inc. | S. pyogenes Cas9 mutant genes and polypeptides encoded by same |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| EP4338799A3 (en) | 2016-10-18 | 2024-06-05 | Regents of the University of Minnesota | Tumor infiltrating lymphocytes and methods of therapy |
| EP3315125A1 (en) | 2016-10-31 | 2018-05-02 | Silence Therapeutics (London) Ltd | Lipid nanoparticle formulation |
| US11732258B2 (en) | 2016-11-02 | 2023-08-22 | President And Fellows Of Harvard College | Engineered guide RNA sequences for in situ detection and sequencing |
| WO2018094356A2 (en) * | 2016-11-18 | 2018-05-24 | Genedit Inc. | Compositions and methods for target nucleic acid modification |
| CA3044101A1 (en) | 2016-11-22 | 2018-05-31 | Integrated Dna Technologies, Inc. | Crispr/cpf1 systems and methods |
| EP3551757A1 (en) | 2016-12-08 | 2019-10-16 | Intellia Therapeutics, Inc. | Modified guide rnas |
| WO2018111947A1 (en) | 2016-12-12 | 2018-06-21 | Integrated Dna Technologies, Inc. | Genome editing enhancement |
| WO2018118587A1 (en) * | 2016-12-22 | 2018-06-28 | Agenovir Corporation | Modified polynucleotides for antiviral therapy |
| JP7383478B2 (ja) | 2016-12-22 | 2023-11-20 | インテリア セラピューティクス,インコーポレイテッド | アルファ1アンチトリプシン欠乏症を治療するための組成物および方法 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| AU2017388379A1 (en) * | 2016-12-28 | 2019-06-06 | Ionis Pharmaceuticals, Inc. | Modified CRISPR RNA and uses thereof |
| US11274300B2 (en) | 2017-01-19 | 2022-03-15 | Proqr Therapeutics Ii B.V. | Oligonucleotide complexes for use in RNA editing |
| KR102709603B1 (ko) | 2017-02-28 | 2024-09-27 | 보르 바이오파마 인크. | 계통 특이적 단백질의 억제를 위한 조성물 및 방법 |
| US20180258485A1 (en) * | 2017-03-07 | 2018-09-13 | The Regents Of The University Of Colorado, A Body Corporate | Boranephosphonate Detection Probes and Methods For Producing and Using the Same |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| EP3596217A1 (en) | 2017-03-14 | 2020-01-22 | Editas Medicine, Inc. | Systems and methods for the treatment of hemoglobinopathies |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| WO2018183808A1 (en) | 2017-03-31 | 2018-10-04 | Agenovir Corporation | Antiviral therapeutic |
| EP3622070A2 (en) | 2017-05-10 | 2020-03-18 | Editas Medicine, Inc. | Crispr/rna-guided nuclease systems and methods |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| BR112019023608A2 (pt) | 2017-05-12 | 2020-05-26 | Crispr Therapeutics Ag | Materiais e métodos para células manipuladas e seus usos em imuno-oncologia |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN108977442B (zh) * | 2017-06-05 | 2023-01-06 | 广州市锐博生物科技有限公司 | 用于dna编辑的系统及其应用 |
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| CN111511375A (zh) | 2017-06-30 | 2020-08-07 | 因提玛生物科学公司 | 用于基因治疗的腺相关病毒载体 |
| EP3652312A1 (en) | 2017-07-14 | 2020-05-20 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| EP3681637A4 (en) * | 2017-09-11 | 2021-06-02 | Synthego Corporation | SYSTEM AND PROCEDURE FOR BIOPOLYMER SYNTHESIS |
| JP7422069B2 (ja) | 2017-09-19 | 2024-01-25 | トロピック バイオサイエンシーズ ユーケー リミテッド | 真核細胞において遺伝子発現をサイレンシングするための非コードrna分子の特異性の改変 |
| KR102907044B1 (ko) | 2017-10-02 | 2026-01-02 | 진에딧 인코포레이티드 | 변형된 cpf1 가이드 rna |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| MA50849A (fr) | 2017-10-26 | 2020-09-02 | Vertex Pharma | Substances et procédés pour le traitement d'hémoglobinopathies |
| US20210277392A1 (en) * | 2017-11-02 | 2021-09-09 | The Governors Of The University Of Alberta | Chemically-modified guide rnas to improve crispr-cas protein specificity |
| JP2021505587A (ja) | 2017-12-05 | 2021-02-18 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Crispr−cas9改変cd34+ヒト造血幹・前駆細胞及びその使用 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US11268092B2 (en) | 2018-01-12 | 2022-03-08 | GenEdit, Inc. | Structure-engineered guide RNA |
| US20190233816A1 (en) * | 2018-01-26 | 2019-08-01 | Massachusetts Institute Of Technology | Structure-guided chemical modification of guide rna and its applications |
| MA51787A (fr) | 2018-02-05 | 2020-12-16 | Vertex Pharma | Substances et méthodes de traitement d'hémoglobinopathies |
| EP3749768A1 (en) | 2018-02-05 | 2020-12-16 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of hemoglobinopathies |
| CN110573184B (zh) * | 2018-02-09 | 2025-05-13 | 俄亥俄州立创新基金会 | Rna纳米结构,其制备方法和用途 |
| IL277234B2 (en) * | 2018-03-14 | 2026-03-01 | Editas Medicine Inc | Systems and methods for treating hemoglobin diseases |
| US20210363518A1 (en) * | 2018-03-19 | 2021-11-25 | University Of Massachusetts | Modified guide rnas for crispr genome editing |
| WO2019183572A1 (en) * | 2018-03-23 | 2019-09-26 | Refuge Biotechnologies, Inc. | Gene regulation via conditional nuclear localization of gene modulating polypeptides |
| WO2019213776A1 (en) * | 2018-05-11 | 2019-11-14 | UNIVERSITé LAVAL | Crispr/cas9 system and uses thereof |
| US20200063100A1 (en) | 2018-05-11 | 2020-02-27 | Crispr Therapeutics Ag | Methods and compositions for treating cancer |
| CN112654710A (zh) | 2018-05-16 | 2021-04-13 | 辛瑟高公司 | 用于指导rna设计和使用的方法和系统 |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| US11833225B2 (en) * | 2018-05-24 | 2023-12-05 | Crispr Therapeutics Ag | Methods and compositions for efficient gene deletion |
| JP7832761B2 (ja) * | 2018-06-08 | 2026-03-18 | インテリア セラピューティクス,インコーポレイテッド | 遺伝子編集のための修飾されたガイドrna |
| EP3810801B1 (en) * | 2018-06-25 | 2022-09-28 | Bionano Genomics, Inc. | Labeling of dna |
| AU2019291918B2 (en) * | 2018-06-29 | 2025-06-12 | Editas Medicine, Inc. | Synthetic guide molecules, compositions and methods relating thereto |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| EP3820503A4 (en) * | 2018-07-13 | 2022-07-13 | Allele Biotechnology & Pharmaceuticals, Inc. | METHODS FOR HIGH SPECIFICITY GENOME EDITING |
| CA3110837A1 (en) * | 2018-08-28 | 2020-03-05 | Vor Biopharma Inc. | Genetically engineered hematopoietic stem cells and uses thereof |
| WO2020047477A1 (en) * | 2018-08-31 | 2020-03-05 | City Of Hope | Cationic compounds for delivery of nucleic acids |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| JP7553100B2 (ja) * | 2018-12-12 | 2024-09-18 | 国立大学法人九州大学 | ゲノム編集された細胞の製造方法 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| GB201901873D0 (en) * | 2019-02-11 | 2019-04-03 | Proqr Therapeutics Ii Bv | Antisense oligonucleotides for nucleic acid editing |
| GB201903521D0 (en) | 2019-03-14 | 2019-05-01 | Tropic Biosciences Uk Ltd | No title |
| GB201903520D0 (en) | 2019-03-14 | 2019-05-01 | Tropic Biosciences Uk Ltd | Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells |
| GB201903519D0 (en) | 2019-03-14 | 2019-05-01 | Tropic Biosciences Uk Ltd | Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CA3138633A1 (en) | 2019-04-30 | 2020-11-05 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| AU2020280103A1 (en) | 2019-05-23 | 2021-12-23 | Vor Biopharma Inc. | Compositions and methods for CD33 modification |
| SG11202113253SA (en) | 2019-06-07 | 2021-12-30 | Scribe Therapeutics Inc | Engineered casx systems |
| US20220259617A1 (en) | 2019-06-13 | 2022-08-18 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| KR20220034717A (ko) * | 2019-07-19 | 2022-03-18 | 신테고 코포레이션 | 안정화된 crispr 복합체 |
| JP7630904B2 (ja) * | 2019-07-23 | 2025-02-18 | 株式会社東芝 | 核酸導入キャリア、核酸導入キャリアセット、核酸導入組成物及び核酸導入方法 |
| AU2020338011A1 (en) | 2019-08-28 | 2022-03-10 | Vor Biopharma Inc. | Compositions and methods for CLL1 modification |
| WO2021041977A1 (en) | 2019-08-28 | 2021-03-04 | Vor Biopharma, Inc. | Compositions and methods for cd123 modification |
| JP2022548957A (ja) * | 2019-09-19 | 2022-11-22 | モデルナティエックス インコーポレイテッド | キャップガイド及びrnaマッピングのためのその使用方法 |
| JP7689949B2 (ja) | 2019-10-03 | 2025-06-09 | アーティサン ディベロップメント ラブズ インコーポレイテッド | 操作されたデュアルガイド核酸を有するcrisprシステム |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN114502566B (zh) | 2019-10-11 | 2025-02-11 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| US12521451B2 (en) | 2019-11-08 | 2026-01-13 | Regeneron Pharmaceuticals, Inc. | CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy |
| AU2020382219A1 (en) | 2019-11-13 | 2022-05-12 | Crispr Therapeutics Ag | Manufacturing process for making T cells expressing chimeric antigen receptors |
| US20230227820A1 (en) * | 2019-11-28 | 2023-07-20 | Korea University Research And Business Foundation | Rna interference-inducing nucleic acid comprising 8-oxoguanine, modified nucleic acid binding to microrna comprising 8-oxoguanine, and uses thereof |
| WO2021119006A1 (en) * | 2019-12-09 | 2021-06-17 | Caribou Biosciences, Inc. | Crispr abasic restricted nucleotides and crispr accuracy via analogs |
| AU2020401206A1 (en) * | 2019-12-11 | 2022-07-14 | Intellia Therapeutics, Inc. | Modified guide RNAs for gene editing |
| CA3162019A1 (en) | 2019-12-20 | 2021-06-24 | Gemma NAVARRO | Lipid nanoparticles for delivery of nucleic acids |
| CN115003680B (zh) | 2020-01-29 | 2025-01-28 | 住友化学株式会社 | 制备核酸寡聚物的方法 |
| KR20220133878A (ko) | 2020-01-29 | 2022-10-05 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| CN115335387A (zh) | 2020-03-27 | 2022-11-11 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| BR112023001272A2 (pt) | 2020-07-24 | 2023-04-04 | Massachusetts Gen Hospital | Partículas semelhantes a vírus aprimoradas e métodos de uso das mesmas para entrega às células |
| EP4204565A1 (en) | 2020-08-28 | 2023-07-05 | Vor Biopharma Inc. | Compositions and methods for cll1 modification |
| EP4204564A1 (en) | 2020-08-28 | 2023-07-05 | Vor Biopharma Inc. | Compositions and methods for cd123 modification |
| EP4211245A1 (en) | 2020-09-14 | 2023-07-19 | Vor Biopharma Inc. | Compositions and methods for cd5 modification |
| WO2022056489A1 (en) | 2020-09-14 | 2022-03-17 | Vor Biopharma, Inc. | Compositions and methods for cd38 modification |
| WO2022061115A1 (en) | 2020-09-18 | 2022-03-24 | Vor Biopharma Inc. | Compositions and methods for cd7 modification |
| CA3193089A1 (en) | 2020-09-18 | 2022-03-24 | Jamie KERSHNER | Constructs and uses thereof for efficient and specific genome editing |
| KR20230074205A (ko) | 2020-09-24 | 2023-05-26 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| WO2022067240A1 (en) | 2020-09-28 | 2022-03-31 | Vor Biopharma, Inc. | Compositions and methods for cd6 modification |
| WO2022072643A1 (en) | 2020-09-30 | 2022-04-07 | Vor Biopharma Inc. | Compositions and methods for cd30 gene modification |
| WO2022075816A1 (ko) * | 2020-10-08 | 2022-04-14 | 주식회사 진코어 | Crispr/cas12f1(cas14a1) 시스템 효율화를 위한 엔지니어링 된 가이드 rna 및 이의 용도 |
| CA3199623A1 (en) | 2020-10-27 | 2022-05-05 | Vor Biopharma Inc. | Compositions and methods for treating hematopoietic malignancy |
| WO2022094245A1 (en) | 2020-10-30 | 2022-05-05 | Vor Biopharma, Inc. | Compositions and methods for bcma modification |
| WO2022104090A1 (en) | 2020-11-13 | 2022-05-19 | Vor Biopharma Inc. | Methods and compositions relating to genetically engineered cells expressing chimeric antigen receptors |
| CN112266951B (zh) * | 2020-11-23 | 2021-07-20 | 广东省农业科学院植物保护研究所 | 一种生物素标记引物延伸方法及其应用 |
| WO2022115878A1 (en) * | 2020-11-30 | 2022-06-02 | The Board Of Trustees Of The Leland Stanford Junior University | Crispr/cas-mediated gene editing of human stem cells |
| AU2021392719B2 (en) | 2020-12-03 | 2025-08-14 | Scribe Therapeutics Inc. | Engineered class 2 type v crispr systems |
| AU2021413252A1 (en) | 2020-12-31 | 2023-06-08 | Vor Biopharma Inc. | Compositions and methods for cd34 gene modification |
| AU2022227650A1 (en) * | 2021-02-25 | 2023-10-12 | Celyntra Therapeutics Sa | Compositions and methods for targeting, editing, or modifying genes |
| WO2022217086A1 (en) | 2021-04-09 | 2022-10-13 | Vor Biopharma Inc. | Photocleavable guide rnas and methods of use thereof |
| CN113512767B (zh) * | 2021-04-30 | 2022-09-23 | 天津诺禾致源生物信息科技有限公司 | 用于构建small RNA文库的接头、试剂盒及small RNA文库的构建方法 |
| WO2022256448A2 (en) | 2021-06-01 | 2022-12-08 | Artisan Development Labs, Inc. | Compositions and methods for targeting, editing, or modifying genes |
| WO2022266139A2 (en) | 2021-06-14 | 2022-12-22 | Graphite Bio, Inc. | Methods to genetically engineer hematopoietic stem and progenitor cells for red cell specific expression of therapeutic proteins |
| CA3223311A1 (en) | 2021-06-18 | 2022-12-22 | Andrea BARGHETTI | Compositions and methods for targeting, editing or modifying human genes |
| WO2023278834A1 (en) * | 2021-07-02 | 2023-01-05 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Kinetic barcoding to enhance specificity of crispr/cas reactions |
| WO2023283585A2 (en) | 2021-07-06 | 2023-01-12 | Vor Biopharma Inc. | Inhibitor oligonucleotides and methods of use thereof |
| WO2023283495A1 (en) * | 2021-07-09 | 2023-01-12 | The Brigham And Women's Hospital, Inc. | Crispr-based protein barcoding and surface assembly |
| EP4381062A1 (en) | 2021-08-02 | 2024-06-12 | Vor Biopharma Inc. | Compositions and methods for gene modification |
| EP4763287A2 (en) | 2021-09-03 | 2026-06-24 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| WO2023039586A1 (en) * | 2021-09-10 | 2023-03-16 | Agilent Technologies, Inc. | Guide rnas with chemical modification for prime editing |
| EP4402266A4 (en) * | 2021-09-14 | 2025-11-05 | Agilent Technologies Inc | GUIDELINES FOR USING RNA WITH CHEMICAL MODIFICATIONS |
| EP4408991A2 (en) | 2021-09-27 | 2024-08-07 | Vor Biopharma Inc. | Fusion polypeptides for genetic editing and methods of use thereof |
| EP4410770A4 (en) | 2021-09-28 | 2026-03-25 | Sumitomo Chemical Co | PROCESS FOR THE PRODUCTION OF PURIFIED DICHLOROACETIC ACID |
| EP4426836A1 (en) * | 2021-11-03 | 2024-09-11 | Intellia Therapeutics, Inc. | Modified guide rnas for gene editing |
| EP4430186A1 (en) | 2021-11-09 | 2024-09-18 | Vor Biopharma Inc. | Compositions and methods for erm2 modification |
| WO2023122508A2 (en) * | 2021-12-23 | 2023-06-29 | Mammoth Biosciences, Inc. | Programmable nuclease-based assay improvements |
| US20250179531A1 (en) | 2022-02-25 | 2025-06-05 | Vor Biopharma Inc. | Compositions and methods for homology-directed repair gene modification |
| EP4486881A1 (en) | 2022-03-01 | 2025-01-08 | Celyntra Therapeutics SA | Composition and methods for transgene insertion |
| EP4488282A4 (en) | 2022-03-23 | 2025-11-19 | Sumitomo Chemical Co | PROCESS FOR THE PRODUCTION OF NUCLEIC ACID OLIGOMERS |
| CN118974256A (zh) | 2022-03-29 | 2024-11-15 | 锐正基因(苏州)有限公司 | 用于治疗转甲状腺素蛋白淀粉样变性的组合物和方法 |
| US20250295695A1 (en) | 2022-04-04 | 2025-09-25 | Vor Biopharma Inc. | Compositions and methods for mediating epitope engineering |
| EP4526884A2 (en) | 2022-05-20 | 2025-03-26 | Artisan Development Labs, Inc. | Systems and methods for assessing risk of genome editing events |
| WO2024015925A2 (en) | 2022-07-13 | 2024-01-18 | Vor Biopharma Inc. | Compositions and methods for artificial protospacer adjacent motif (pam) generation |
| CN119403816A (zh) | 2022-07-22 | 2025-02-07 | 住友化学株式会社 | 寡核苷酸的制造方法 |
| EP4563559A4 (en) | 2022-07-28 | 2026-07-15 | Sumitomo Chemical Co | THIONIZATION SOLUTION |
| EP4590820A2 (en) | 2022-09-22 | 2025-07-30 | Accuredit Therapeutics (Suzhou) Co., Ltd. | Compositions and methods for treatment of hypercholesterolemia and/or cardiovascular disease |
| WO2024073751A1 (en) | 2022-09-29 | 2024-04-04 | Vor Biopharma Inc. | Methods and compositions for gene modification and enrichment |
| JP7825064B2 (ja) | 2022-10-27 | 2026-03-05 | 住友化学株式会社 | オリゴヌクレオチドの製造方法 |
| WO2024137533A1 (en) | 2022-12-19 | 2024-06-27 | Graphite Bio, Inc. | Improved peptide inhibitors of p53 binding protein 53bp1 |
| WO2024138131A1 (en) * | 2022-12-22 | 2024-06-27 | Trustees Of Tufts College | Expanding applications of zgtc alphabet in protein expression and gene editing |
| WO2024140737A1 (en) * | 2022-12-26 | 2024-07-04 | Huidagene Therapeutics Co., Ltd. | Modified guide rna and uses thereof |
| WO2024143276A1 (ja) | 2022-12-26 | 2024-07-04 | 住友化学株式会社 | オリゴヌクレオチドの製造方法 |
| US20260234701A1 (en) * | 2023-02-01 | 2026-08-13 | University Hospitals Cleveland Medical Center | Crispr technologies for diagnostic applications |
| WO2024168312A1 (en) | 2023-02-09 | 2024-08-15 | Vor Biopharma Inc. | Methods for treating hematopoietic malignancy |
| KR20250153298A (ko) | 2023-03-08 | 2025-10-24 | 큐어백 에스이 | 핵산 전달을 위한 신규의 지질 나노입자 제형 |
| TW202444388A (zh) * | 2023-04-07 | 2024-11-16 | 美商建南德克公司 | 經修飾的引導rna |
| KR20260007576A (ko) * | 2023-04-28 | 2026-01-14 | 빔 테라퓨틱스, 인크. | 변형된 가이드 rna |
| JP2026523341A (ja) | 2023-05-15 | 2026-07-14 | エヌクロマ・バイオ,インコーポレーテッド | Hbv遺伝子発現のエピジェネティック調節のための組成物および方法 |
| WO2025030010A1 (en) | 2023-08-01 | 2025-02-06 | Vor Biopharma Inc. | Compositions comprising genetically engineered hematopoietic stem cells and methods of use thereof |
| WO2025076141A1 (en) | 2023-10-03 | 2025-04-10 | Inari Agriculture Technology, Inc. | Viral delivery of grna to the scion |
| WO2025229953A1 (ja) | 2024-04-30 | 2025-11-06 | 住友化学株式会社 | オリゴヌクレオチドの製造方法 |
| WO2026020120A1 (en) * | 2024-07-19 | 2026-01-22 | University Of Massachusetts | Increasing cas9 genome editing fidelity through attenuation of guide rna watson-crick base pairing potential |
Family Cites Families (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5032401A (en) | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US7371580B2 (en) | 2001-08-24 | 2008-05-13 | Agilent Technologies, Inc. | Use of unstructured nucleic acids in assaying nucleic acid molecules |
| WO2005065419A2 (en) | 2003-12-29 | 2005-07-21 | Am Biosolutions | Method of culturing cells |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| PL2476689T3 (pl) | 2007-05-10 | 2016-04-29 | Agilent Technologies Inc | Tiowęglowe grupy zabezpieczające do syntezy RNA |
| US20100076183A1 (en) | 2008-09-22 | 2010-03-25 | Dellinger Douglas J | Protected monomer and method of final deprotection for rna synthesis |
| US9585920B2 (en) | 2011-02-04 | 2017-03-07 | Katherine Rose Kovarik | Method and system for treating cancer cachexia |
| US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
| GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| EP2836226B1 (en) | 2012-02-24 | 2017-06-28 | Fred Hutchinson Cancer Research Center | Compositions and methods for the treatment of hemoglobinopathies |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| US9637739B2 (en) | 2012-03-20 | 2017-05-02 | Vilnius University | RNA-directed DNA cleavage by the Cas9-crRNA complex |
| EP3747891A3 (en) | 2012-05-21 | 2021-03-24 | Agilent Technologies, Inc. | Compositions and methods for conjugating oligonucleotides |
| ES2728782T3 (es) | 2012-05-25 | 2019-10-28 | Univ California | Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN |
| US20140075593A1 (en) | 2012-09-07 | 2014-03-13 | Dow Agrosciences Llc | Fluorescence activated cell sorting (facs) enrichment to generate plants |
| UA119135C2 (uk) | 2012-09-07 | 2019-05-10 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб отримання трансгенної рослини |
| UA118090C2 (uk) | 2012-09-07 | 2018-11-26 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив |
| BR112015004995B1 (pt) | 2012-09-07 | 2023-05-02 | Sangamo Biosciences, Inc. | Método para modificação do genoma de uma célula, uso de uma célula, semente ou planta obtida pelo referido método e nuclease de dedo de zinco sítio específica |
| EP4397759A3 (en) | 2012-10-23 | 2024-10-09 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| US20150315576A1 (en) | 2012-11-01 | 2015-11-05 | Massachusetts Institute Of Technology | Genetic device for the controlled destruction of dna |
| CA2890110C (en) | 2012-11-01 | 2023-05-02 | Factor Bioscience Inc. | Methods and products for expressing proteins in cells |
| DK3363902T3 (da) | 2012-12-06 | 2020-01-02 | Sigma Aldrich Co Llc | Crispr-baseret genommodifikation og -regulering |
| CA2892821C (en) | 2012-12-06 | 2022-04-26 | Synthetic Genomics, Inc. | Algal mutants having a locked-in high light acclimated phenotype |
| WO2014089513A1 (en) | 2012-12-06 | 2014-06-12 | Synthetic Genomics, Inc. | Autonomous replication sequences and episomal dna molecules |
| PT2931898E (pt) | 2012-12-12 | 2016-06-16 | Harvard College | Manipulação e otimização de sistemas, métodos e composições para manipulação de sequências com domínios funcionais |
| EP3064585B1 (en) | 2012-12-12 | 2020-02-05 | The Broad Institute, Inc. | Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| EP2931899A1 (en) | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| WO2014093688A1 (en) | 2012-12-12 | 2014-06-19 | 1Massachusetts Institute Of Technology | Compositions and methods for functional nucleic acid delivery |
| CN105209621B (zh) | 2012-12-12 | 2021-05-25 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| WO2014093709A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| MX380562B (es) * | 2012-12-12 | 2025-03-12 | Broad Inst Inc | Modificaciones de sistemas, métodos y composiciones guía optimizadas para la manipulación de secuencias. |
| SG10201707569YA (en) | 2012-12-12 | 2017-10-30 | Broad Inst Inc | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications |
| KR102955556B1 (ko) | 2012-12-12 | 2026-04-22 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물 |
| WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
| IL308158A (en) | 2012-12-17 | 2023-12-01 | Harvard College | Rna-guided human genome engineering |
| WO2014159719A1 (en) | 2013-03-14 | 2014-10-02 | Scrips Health | Methods of isolating nucleic acids |
| WO2014153118A1 (en) | 2013-03-14 | 2014-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1) |
| ES2749624T3 (es) | 2013-03-14 | 2020-03-23 | Caribou Biosciences Inc | Composiciones y métodos de ácidos nucleicos dirigidos a ácido nucleico |
| US20140364333A1 (en) | 2013-03-15 | 2014-12-11 | President And Fellows Of Harvard College | Methods for Live Imaging of Cells |
| JP2016512048A (ja) | 2013-03-15 | 2016-04-25 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | CRISPR/Casシステムを使用した植物ゲノム操作 |
| US9957515B2 (en) | 2013-03-15 | 2018-05-01 | Cibus Us Llc | Methods and compositions for targeted gene modification |
| EP2971006A4 (en) | 2013-03-15 | 2017-02-08 | Transposagen Biopharmaceuticals, Inc. | Reproducible method for testis-mediated genetic modification (tgm) and sperm-mediated genetic modification (sgm) |
| US9234213B2 (en) * | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| US11332719B2 (en) | 2013-03-15 | 2022-05-17 | The Broad Institute, Inc. | Recombinant virus and preparations thereof |
| CN105408483A (zh) | 2013-03-15 | 2016-03-16 | 通用医疗公司 | 遗传和表观遗传调节蛋白至特定基因组基因座的rna引导的靶向 |
| US20140273230A1 (en) | 2013-03-15 | 2014-09-18 | Sigma-Aldrich Co., Llc | Crispr-based genome modification and regulation |
| US20140349400A1 (en) | 2013-03-15 | 2014-11-27 | Massachusetts Institute Of Technology | Programmable Modification of DNA |
| EP4286517A3 (en) | 2013-04-04 | 2024-03-13 | President and Fellows of Harvard College | Therapeutic uses of genome editing with crispr/cas systems |
| ES2747833T3 (es) | 2013-04-04 | 2020-03-11 | Dartmouth College | Composiciones y procedimientos para la escisión in vivo del ADN proviral del vih-1 |
| WO2014172470A2 (en) | 2013-04-16 | 2014-10-23 | Whitehead Institute For Biomedical Research | Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| EP2986709A4 (en) | 2013-04-16 | 2017-03-15 | University Of Washington Through Its Center For Commercialization | Activating an alternative pathway for homology-directed repair to stimulate targeted gene correction and genome engineering |
| EP2997146A4 (en) | 2013-05-15 | 2017-04-26 | Sangamo BioSciences, Inc. | Methods and compositions for treatment of a genetic condition |
| JP6608807B2 (ja) | 2013-05-29 | 2019-11-20 | セレクティス | Rnaガイドcasヌクレアーゼ系を用いることによって免疫療法のためにt細胞を操作するための方法 |
| EP3004339B1 (en) | 2013-05-29 | 2021-07-07 | Cellectis | New compact scaffold of cas9 in the type ii crispr system |
| US9873907B2 (en) | 2013-05-29 | 2018-01-23 | Agilent Technologies, Inc. | Method for fragmenting genomic DNA using CAS9 |
| DK3004349T3 (en) | 2013-05-29 | 2018-06-06 | Cellectis Sa | A method for producing precise DNA cleavage using CAS9 nickase activity |
| EP3603679B1 (en) | 2013-06-04 | 2022-08-10 | President and Fellows of Harvard College | Rna-guided transcriptional regulation |
| EP3008181B1 (en) | 2013-06-11 | 2019-11-06 | The Regents of The University of California | Methods and compositions for target dna modification |
| US20150315252A1 (en) | 2013-06-11 | 2015-11-05 | Clontech Laboratories, Inc. | Protein enriched microvesicles and methods of making and using the same |
| WO2014204723A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions |
| SG11201510327TA (en) | 2013-06-17 | 2016-01-28 | Broad Inst Inc | Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells |
| JP6738728B2 (ja) | 2013-06-17 | 2020-08-19 | ザ・ブロード・インスティテュート・インコーポレイテッド | 肝臓ターゲティングおよび治療のためのCRISPR−Cas系、ベクターおよび組成物の送達および使用 |
| WO2014204725A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation |
| ES2777217T3 (es) | 2013-06-17 | 2020-08-04 | Broad Inst Inc | Suministro, modificación y optimización de sistemas de guía en tándem, métodos y composiciones para la manipulación de secuencias |
| KR20260047646A (ko) | 2013-07-09 | 2026-04-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 멀티플렉스 rna-가이드된 게놈 조작 |
| JP2016528890A (ja) | 2013-07-09 | 2016-09-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | CRISPR/Cas系を用いるゲノム編集の治療用の使用 |
| CN105517579B (zh) | 2013-07-10 | 2019-11-15 | 哈佛大学校长及研究员协会 | 用于RNA向导的基因调节和编辑的正交Cas9蛋白 |
| WO2015006437A1 (en) | 2013-07-10 | 2015-01-15 | Majzoub Joseph A | Mrap2 knockouts |
| US11306328B2 (en) | 2013-07-26 | 2022-04-19 | President And Fellows Of Harvard College | Genome engineering |
| US20150044772A1 (en) | 2013-08-09 | 2015-02-12 | Sage Labs, Inc. | Crispr/cas system-based novel fusion protein and its applications in genome editing |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| CN106133138A (zh) | 2013-08-22 | 2016-11-16 | 先锋国际良种公司 | 使用引导多核苷酸/cas内切核酸酶系统的基因组修饰及其使用方法 |
| WO2015035034A1 (en) | 2013-09-04 | 2015-03-12 | Mice With Horns, Llc | Materials and methods for correcting recessive mutations in animals |
| KR20160048212A (ko) | 2013-09-04 | 2016-05-03 | 씨에스아이알 | 유전자 발현을 침묵화시키기 위해 유전자 조절 인자들을 표적으로하는 부위-특이적인 뉴클레아제 단일 세포 분석법 |
| BR102014021800B1 (pt) | 2013-09-04 | 2022-03-29 | Dow Agrosciences Llc | Método para detectar a integração específica de sítio de uma sequência de doador de polinucleotídeo dentro de um sítio-alvo genômico |
| US20150071946A1 (en) | 2013-09-06 | 2015-03-12 | The Johns Hopkins University | Tumor-specific retrotransposon insertions |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| WO2015040075A1 (en) | 2013-09-18 | 2015-03-26 | Genome Research Limited | Genomic screening methods using rna-guided endonucleases |
| ES2681622T3 (es) | 2013-09-18 | 2018-09-14 | Kymab Limited | Métodos, células y organismos |
| DE102013111099B4 (de) | 2013-10-08 | 2023-11-30 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Permanente Genkorrektur mittels nukleotidmodifizierter messenger RNA |
| US20150098954A1 (en) | 2013-10-08 | 2015-04-09 | Elwha Llc | Compositions and Methods Related to CRISPR Targeting |
| WO2015052231A2 (en) | 2013-10-08 | 2015-04-16 | Technical University Of Denmark | Multiplex editing system |
| US20160251675A1 (en) | 2013-10-08 | 2016-09-01 | International Rice Research Institute | Drought-Resistant Cereal Grasses and Related Materials and Methods |
| WO2015066643A1 (en) | 2013-11-04 | 2015-05-07 | Dow Agrosciences Llc | Optimal soybean loci |
| JP6633532B2 (ja) | 2013-11-04 | 2020-01-22 | ダウ アグロサイエンシィズ エルエルシー | 最適なトウモロコシ遺伝子座 |
| EP3066110B1 (en) | 2013-11-04 | 2021-12-29 | Corteva Agriscience LLC | Optimal maize loci |
| CN105980395A (zh) | 2013-11-04 | 2016-09-28 | 美国陶氏益农公司 | 最优大豆座位 |
| BR102014027448A8 (pt) | 2013-11-04 | 2021-08-24 | Dow Agrosciences Llc | cassete de doador de polinucleotídeo, uso de uma planta, de uma parte de planta, ou de uma célula vegetal compreendendo o referido cassete, e método para integração direcionada do mesmo |
| CN111218447B (zh) | 2013-11-07 | 2024-10-11 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US11326209B2 (en) | 2013-11-07 | 2022-05-10 | Massachusetts Institute Of Technology | Cell-based genomic recorded accumulative memory |
| US9074199B1 (en) | 2013-11-19 | 2015-07-07 | President And Fellows Of Harvard College | Mutant Cas9 proteins |
| WO2015075056A1 (en) | 2013-11-19 | 2015-05-28 | Thermo Fisher Scientific Baltics Uab | Programmable enzymes for isolation of specific dna fragments |
| US10787684B2 (en) | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
| CN105899658B (zh) | 2013-12-12 | 2020-02-18 | 布罗德研究所有限公司 | 针对hbv和病毒性疾病以及障碍的crispr-cas系统和组合物的递送、用途和治疗应用 |
| CN111206032B (zh) | 2013-12-12 | 2024-07-19 | 布罗德研究所有限公司 | 用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用 |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| WO2015089473A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation |
| WO2015089419A2 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components |
| EP3835419A1 (en) | 2013-12-12 | 2021-06-16 | The Regents of The University of California | Methods and compositions for modifying a single stranded target nucleic acid |
| CA2932439A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute, Inc. | Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes |
| JP6793547B2 (ja) | 2013-12-12 | 2020-12-02 | ザ・ブロード・インスティテュート・インコーポレイテッド | 最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物 |
| KR20160097338A (ko) | 2013-12-12 | 2016-08-17 | 더 브로드 인스티튜트, 인코퍼레이티드 | 뉴클레오티드 반복 장애에서의 crispr-cas 시스템의 조성물 및 방법 및 용도 |
| WO2015184262A1 (en) | 2014-05-30 | 2015-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods of delivering treatments for latent viral infections |
| US20150344836A1 (en) | 2014-05-30 | 2015-12-03 | Ohio State Innovation Foundation | Agrobacterium Strains for Plant Transformation and Related Materials and Methods |
| AU2015280069B2 (en) | 2014-06-23 | 2021-08-12 | The General Hospital Corporation | Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq) |
| US9738897B2 (en) | 2014-06-23 | 2017-08-22 | Regeneron Pharmaceuticals, Inc. | Nuclease-mediated DNA assembly |
| WO2015200725A1 (en) | 2014-06-25 | 2015-12-30 | Cold Spring Harbor Laboratory | Methods and compositions for inhibiting growth and epithelial to mesenchymal transition (emt) in cancer cells |
| WO2015200555A2 (en) | 2014-06-25 | 2015-12-30 | Caribou Biosciences, Inc. | Rna modification to engineer cas9 activity |
| US9616090B2 (en) | 2014-07-30 | 2017-04-11 | Sangamo Biosciences, Inc. | Gene correction of SCID-related genes in hematopoietic stem and progenitor cells |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| ES2730378T3 (es) | 2014-08-27 | 2019-11-11 | Caribou Biosciences Inc | Procedimientos para incrementar la eficiencia de la modificación mediada por Cas9 |
| JP6594955B2 (ja) | 2014-08-27 | 2019-10-23 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | シントン形成 |
| WO2016049163A2 (en) | 2014-09-24 | 2016-03-31 | The Broad Institute Inc. | Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder |
| WO2016049024A2 (en) | 2014-09-24 | 2016-03-31 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo |
| WO2016049251A1 (en) | 2014-09-24 | 2016-03-31 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes |
| EP3197270B1 (en) | 2014-09-26 | 2025-12-03 | Pioneer Hi-Bred International, Inc. | Wheat ms1 polynucleotides, polypeptides, and methods of use |
| EP3198036A4 (en) | 2014-09-26 | 2018-08-08 | Two Pore Guys, Inc. | Target sequence detection by nanopore sensing of synthetic probes |
| RU2721799C2 (ru) | 2014-09-26 | 2020-05-22 | Филип Моррис Продактс С.А. | Уменьшение содержания табак-специфичных нитрозаминов посредством изменения пути ассимиляции нитратов |
| WO2016073079A2 (en) | 2014-09-26 | 2016-05-12 | Yale University | Compositions and methods for biocontainment of microorganisms |
| AU2015330855A1 (en) | 2014-10-09 | 2017-04-27 | Celularity Inc. | Placenta-derived adherent cell exosomes and uses thereof |
| CN113930455A (zh) | 2014-10-09 | 2022-01-14 | 生命技术公司 | Crispr寡核苷酸和基因剪辑 |
| CA2963940A1 (en) | 2014-10-09 | 2016-04-14 | The Regents Of The University Of California | Targeted disruption of a csf1-dap12 pathway member gene for the treatment of neuropathic pain |
| KR102546296B1 (ko) | 2014-10-31 | 2023-06-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도 |
| US9816080B2 (en) | 2014-10-31 | 2017-11-14 | President And Fellows Of Harvard College | Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs) |
| TWI716367B (zh) | 2014-10-31 | 2021-01-21 | 麻省理工學院 | 用於常間回文重複序列叢集(crispr)之大量平行組合性基因學 |
| CA2969619A1 (en) | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| CN107787367B (zh) * | 2015-04-06 | 2021-10-26 | 里兰斯坦福初级大学理事会 | 用于crispr/cas介导的基因调控的化学修饰的引导rna |
| WO2017106657A1 (en) | 2015-12-18 | 2017-06-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| EP3390624A4 (en) | 2015-12-18 | 2019-07-10 | The Regents of The University of California | Modified site-directed modifying polypeptides and methods of use thereof |
| EP3392337B1 (en) | 2015-12-18 | 2024-03-06 | Japan Science and Technology Agency | Genetic modification non-human organism, egg cells, fertilized eggs, and method for modifying target genes |
| EP3708665A1 (en) | 2015-12-18 | 2020-09-16 | Danisco US Inc. | Methods and compositions for t-rna based guide rna expression |
| WO2017106767A1 (en) | 2015-12-18 | 2017-06-22 | The Scripps Research Institute | Production of unnatural nucleotides using a crispr/cas9 system |
| EP3390632B1 (en) | 2015-12-18 | 2025-09-10 | Danisco US Inc. | Methods and compositions for polymerase ii (pol-ii) based guide rna expression |
-
2015
- 2015-12-03 CA CA2969619A patent/CA2969619A1/en active Pending
- 2015-12-03 AU AU2015355546A patent/AU2015355546B2/en active Active
- 2015-12-03 EP EP24165113.2A patent/EP4400584A3/en active Pending
- 2015-12-03 KR KR1020177018311A patent/KR102629128B1/ko active Active
- 2015-12-03 EP EP15866342.7A patent/EP3227447B1/en active Active
- 2015-12-03 JP JP2017529610A patent/JP7068821B2/ja active Active
- 2015-12-03 US US14/757,204 patent/US10900034B2/en active Active
- 2015-12-03 CN CN201580075275.4A patent/CN107250148B/zh active Active
- 2015-12-03 WO PCT/US2015/000143 patent/WO2016089433A1/en not_active Ceased
- 2015-12-03 KR KR1020247002012A patent/KR102763527B1/ko active Active
-
2017
- 2017-05-26 US US15/607,295 patent/US10337001B2/en active Active
-
2020
- 2020-11-24 US US17/103,678 patent/US20210079389A1/en active Pending
-
2022
- 2022-02-14 JP JP2022020615A patent/JP7579820B2/ja active Active
-
2023
- 2023-06-09 US US18/332,464 patent/US20230416733A1/en not_active Abandoned
-
2024
- 2024-09-12 US US18/883,302 patent/US20250092389A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2494940T3 (es) | Moduladores de factores de coagulación mejorados | |
| EP4527459A3 (en) | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof | |
| Steinkraus et al. | Tiny giants of gene regulation: experimental strategies for microRNA functional studies | |
| HRP20231022T1 (hr) | Hibridni polinukleotidi crispr dna/rna i načini uporabe | |
| EP4455285A3 (en) | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof | |
| JP2015142558A5 (enExample) | ||
| JP2018512041A5 (enExample) | ||
| HRP20210612T1 (hr) | Postupci i pripravci za specifičnu inhibiciju glikolat oksidaze (hao1) pomoću dvolančane rnk | |
| JP2014527401A5 (enExample) | ||
| JP2022137068A (ja) | 化学的に修飾されたガイドrnaを使用する高特異性ゲノム編集 | |
| JP2021530988A5 (enExample) | ||
| RU2017117510A (ru) | Редактирование целевой рнк | |
| HRP20240657T1 (hr) | Materijali i postupci za liječenje hemoglobinopatija | |
| WO2017181107A2 (en) | Modified cpf1 mrna, modified guide rna, and uses thereof | |
| EP4310196A3 (en) | Methods and compositions for manipulating nucleic acids | |
| JP2019508051A5 (enExample) | ||
| JP2017093448A5 (enExample) | ||
| EP3012324A3 (en) | Modulation of hsp47 expression | |
| RU2015128098A (ru) | Конструирование систем, способы и оптимизированные направляющие композиции для манипуляции с последовательностями | |
| RU2013139298A (ru) | Способ конструирования специфичных промоторов | |
| WO2014108850A3 (en) | High throughput transcriptome analysis | |
| JP2024534945A5 (enExample) | ||
| JP2024107295A5 (enExample) | ||
| CA3216819A1 (en) | Gene expression regulatory system using crispr system | |
| JP2024531728A5 (enExample) |