|
US5837258A
(en)
|
1991-08-30 |
1998-11-17 |
University Of South Florida |
Induction of tissue, bone or cartilage formation using connective tissue growth factor
|
|
DE10160151A1
(de)
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
|
US8202979B2
(en)
*
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
SI1407044T2
(en)
|
2000-12-01 |
2018-03-30 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Rna interference mediating small rna molecules
|
|
US20050282188A1
(en)
|
2001-05-18 |
2005-12-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
|
US20080188430A1
(en)
|
2001-05-18 |
2008-08-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
|
WO2003035876A1
(de)
|
2001-10-26 |
2003-05-01 |
Ribopharma Ag |
Verwendung einer doppelsträngigen ribonukleinsäure zur behandlung einer infektion mit einem (+)-strang-rna-virus
|
|
US20040138163A1
(en)
|
2002-05-29 |
2004-07-15 |
Mcswiggen James |
RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
KR101201664B1
(ko)
*
|
2002-08-05 |
2012-11-15 |
사일런스 테라퓨틱스 아게 |
신규한 형태의 간섭 rna 분자
|
|
WO2006006948A2
(en)
*
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
JP2006507841A
(ja)
|
2002-11-14 |
2006-03-09 |
ダーマコン, インコーポレイテッド |
機能的siRNAおよび超機能的siRNA
|
|
ATE479752T1
(de)
*
|
2003-03-07 |
2010-09-15 |
Alnylam Pharmaceuticals Inc |
Therapeutische zusammensetzungen
|
|
CA2524255C
(en)
|
2003-03-21 |
2014-02-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
US20040198640A1
(en)
|
2003-04-02 |
2004-10-07 |
Dharmacon, Inc. |
Stabilized polynucleotides for use in RNA interference
|
|
US20050136437A1
(en)
|
2003-08-25 |
2005-06-23 |
Nastech Pharmaceutical Company Inc. |
Nanoparticles for delivery of nucleic acids and stable double-stranded RNA
|
|
KR20110007263A
(ko)
*
|
2003-08-28 |
2011-01-21 |
노파르티스 아게 |
블런트-말단 및 3'-변형체를 갖는 간섭 rna 이중나선
|
|
US20060134787A1
(en)
|
2004-12-22 |
2006-06-22 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
|
|
WO2005062937A2
(en)
|
2003-12-22 |
2005-07-14 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended sirna
|
|
US20060069050A1
(en)
|
2004-02-17 |
2006-03-30 |
University Of Massachusetts |
Methods and compositions for mediating gene silencing
|
|
JP4937899B2
(ja)
*
|
2004-03-12 |
2012-05-23 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
VEGFを標的とするiRNA物質
|
|
KR101147147B1
(ko)
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
WO2006031901A2
(en)
|
2004-09-10 |
2006-03-23 |
Somagenics, Inc. |
SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF
|
|
EP1802644B1
(en)
*
|
2004-09-24 |
2012-11-07 |
Alnylam Pharmaceuticals Inc. |
Rnai modulation of apob and uses thereof
|
|
US20060142228A1
(en)
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
|
TWI386225B
(zh)
|
2004-12-23 |
2013-02-21 |
Alcon Inc |
用於治療眼睛病症的結締組織生長因子(CTGF)RNA干擾(RNAi)抑制技術
|
|
CN101184839A
(zh)
|
2005-04-08 |
2008-05-21 |
纳斯泰克制药公司 |
用于呼吸道病毒感染的RNAi治疗
|
|
ATE546526T1
(de)
|
2005-05-25 |
2012-03-15 |
Univ York |
Hybrid-interferenz-rna
|
|
EP1896069B1
(en)
|
2005-06-24 |
2013-03-13 |
Intervet International BV |
Inactivated chimeric vaccines and related methods of use
|
|
JP2009502138A
(ja)
*
|
2005-07-21 |
2009-01-29 |
アルナイラム ファーマシューティカルズ インコーポレイテッド |
RhoA遺伝子のRNAi調節及びその使用法
|
|
JP2009504782A
(ja)
*
|
2005-08-18 |
2009-02-05 |
アルナイラム ファーマシューティカルズ インコーポレイテッド |
神経疾患を治療するための方法および組成物
|
|
FR2890859B1
(fr)
|
2005-09-21 |
2012-12-21 |
Oreal |
Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase
|
|
WO2007041282A2
(en)
|
2005-09-29 |
2007-04-12 |
The Johns Hopkins University |
Methods and compositions for treatment of cystic fibrosis
|
|
US7825099B2
(en)
|
2006-01-20 |
2010-11-02 |
Quark Pharmaceuticals, Inc. |
Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
|
|
WO2007089607A2
(en)
|
2006-01-26 |
2007-08-09 |
University Of Massachusetts |
Rna silencing agents for use in therapy and nanotransporters for efficient delivery of same
|
|
CN103215293B
(zh)
|
2006-01-27 |
2015-10-28 |
比奥根Ma公司 |
Nogo受体拮抗剂
|
|
US20070218495A1
(en)
|
2006-03-16 |
2007-09-20 |
Dharmacon, Inc. |
Methods, libraries and computer program products for gene silencing with reduced off-target effects
|
|
US7700541B2
(en)
|
2006-04-06 |
2010-04-20 |
Nitto Denko Corporation |
Biodegradable cationic polymers
|
|
GB0608838D0
(en)
*
|
2006-05-04 |
2006-06-14 |
Novartis Ag |
Organic compounds
|
|
JP2010519907A
(ja)
|
2007-03-02 |
2010-06-10 |
エムディーアールエヌエー,インコーポレイテッド |
Vegfファミリー遺伝子の発現を抑制するための核酸化合物およびその使用
|
|
US20100105134A1
(en)
|
2007-03-02 |
2010-04-29 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting gene expression and uses thereof
|
|
EP2530152B1
(en)
|
2007-05-31 |
2017-12-27 |
University of Iowa Research Foundation |
Reduction of off-target RNA interference toxicity
|
|
WO2009002462A1
(en)
|
2007-06-22 |
2008-12-31 |
The Board Of Trustees Of The Leland Stanford Junior University |
Pre-mirna loop-modulated target regulation
|
|
WO2009020344A2
(en)
|
2007-08-06 |
2009-02-12 |
Postech Acad Ind Found |
Small interfering rnas (sirnas) controlling multiple target genes and method for preparing the same
|
|
ES2873350T3
(es)
|
2007-08-27 |
2021-11-03 |
1Globe Health Inst Llc |
Composiciones de ARN interferente asimétrico y usos de las mismas
|
|
EP2195428B1
(en)
|
2007-09-19 |
2013-12-11 |
Applied Biosystems, LLC |
SiRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAi, AND STABILIZED FORMS THEREOF
|
|
US20090131360A1
(en)
*
|
2007-10-02 |
2009-05-21 |
Rxi Pharmaceuticals, Corp. |
Tripartite RNAi constructs
|
|
AU2008306455C1
(en)
*
|
2007-10-03 |
2014-04-17 |
Quark Pharmaceuticals, Inc. |
Novel siRNA structures
|
|
US8614311B2
(en)
|
2007-12-12 |
2013-12-24 |
Quark Pharmaceuticals, Inc. |
RTP801L siRNA compounds and methods of use thereof
|
|
KR100949791B1
(ko)
|
2007-12-18 |
2010-03-30 |
이동기 |
오프-타겟 효과를 최소화하고 RNAi 기구를 포화시키지않는 신규한 siRNA 구조 및 그 용도
|
|
CA2731779A1
(en)
|
2008-07-24 |
2010-01-28 |
Rxi Pharmaceuticals Corporation |
Rnai constructs and uses therof
|
|
US8946172B2
(en)
*
|
2008-08-25 |
2015-02-03 |
Excaliard Pharmaceuticals, Inc. |
Method for reducing scarring during wound healing using antisense compounds directed to CTGF
|
|
WO2010026660A1
(ja)
|
2008-09-08 |
2010-03-11 |
学校法人福岡大学 |
Zfat遺伝子発現抑制rna
|
|
CN102405286A
(zh)
*
|
2008-09-22 |
2012-04-04 |
阿克赛医药公司 |
减小大小的自递送RNAi化合物
|
|
US20100227920A1
(en)
|
2008-09-29 |
2010-09-09 |
The Regents Of The University Of California |
Aldehyde dehydrogenase inhibitors as novel depigmenting agents
|
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
EP2398903A1
(en)
|
2009-02-18 |
2011-12-28 |
Silence Therapeutics Aktiengesellschaft |
Means for inhibiting the expression of ang2
|
|
WO2010107952A2
(en)
*
|
2009-03-19 |
2010-09-23 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
ES2921573T3
(es)
|
2009-04-03 |
2022-08-29 |
Dicerna Pharmaceuticals Inc |
Métodos y composiciones para la inhibición específica de KRAS por RNA bicatenario asimétrico
|
|
WO2011019887A2
(en)
|
2009-08-14 |
2011-02-17 |
Massachusetts Institute Of Technology |
Waveguide coupler having continuous three-dimensional tapering
|
|
KR101237036B1
(ko)
*
|
2009-11-04 |
2013-02-25 |
성균관대학교산학협력단 |
안티센스 가닥에 의한 오프-타겟 효과를 최소화한 신규한 siRNA 구조 및 그 용도
|
|
KR101207561B1
(ko)
|
2009-12-15 |
2012-12-04 |
주식회사 코리아나화장품 |
티로시나제의 발현을 저해하는 siRNA 올리고뉴클레오타이드 및 이를 함유하는 화장료 조성물
|
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
|
US8859755B2
(en)
|
2010-03-05 |
2014-10-14 |
Chiralgen, Ltd. |
Method for preparing ribonucleoside phosphorothioate
|
|
EP2550001B1
(en)
*
|
2010-03-24 |
2019-05-22 |
Phio Pharmaceuticals Corp. |
Rna interference in ocular indications
|
|
WO2011140659A1
(en)
|
2010-05-12 |
2011-11-17 |
Centre Hospitalier De L'universite De Montreal |
Screening assays based on mag and/or abhd6 for selecting insulin secretion promoting agents
|
|
CA2812046A1
(en)
*
|
2010-09-15 |
2012-03-22 |
Alnylam Pharmaceuticals, Inc. |
Modified irna agents
|
|
WO2012053741A2
(ko)
|
2010-10-22 |
2012-04-26 |
성균관대학교산학협력단 |
Rna 간섭을 유도하는 핵산 분자 및 그 용도
|
|
WO2012078536A2
(en)
|
2010-12-06 |
2012-06-14 |
Quark Pharmaceuticals, Inc. |
Double stranded oligonucleotide compounds comprising positional modifications
|
|
CN103635197A
(zh)
*
|
2011-02-02 |
2014-03-12 |
埃克斯利尔德生物制药公司 |
使用靶向结缔组织生长因子(ctgf)的反义化合物治疗疤痕疙瘩或肥大性疤痕的方法
|
|
JP6132775B2
(ja)
|
2011-03-03 |
2017-05-24 |
クォーク ファーマシューティカルズ インコーポレーティッドQuark Pharmaceuticals,Inc. |
Toll様受容体経路のオリゴヌクレオチド修飾因子
|
|
CN102719432B
(zh)
|
2011-03-29 |
2013-10-23 |
南京大学 |
特异性抑制肿瘤凋亡抑制基因Bcl2的双链不对称小核酸干扰分子asiRNA及其应用
|
|
KR101590586B1
(ko)
|
2011-05-30 |
2016-02-01 |
성균관대학교산학협력단 |
표적 유전자 발현 억제 및 면역 반응을 동시에 유발하는 이중가닥의 긴 간섭 rna
|
|
EP3366302B1
(en)
|
2011-07-18 |
2021-12-08 |
University Of Kentucky Research Foundation |
Protection of cells from alu-rna-induced degeneration and inhibitors for protecting cells
|
|
US9707235B1
(en)
|
2012-01-13 |
2017-07-18 |
University Of Kentucky Research Foundation |
Protection of cells from degeneration and treatment of geographic atrophy
|
|
ES2716818T3
(es)
|
2012-05-22 |
2019-06-17 |
Olix Pharmaceuticals Inc |
Molécula de ácido nucleico inductora de interferencias de arn capaz de penetrar en las células y uso de la misma
|
|
US9611473B2
(en)
|
2012-09-12 |
2017-04-04 |
Quark Pharmaceuticals, Inc. |
Double-stranded nucleic acid compounds
|
|
MX382210B
(es)
|
2013-07-05 |
2025-03-13 |
Bioneer Corp |
(arnip) gen especifico relacionado con las enfermedades respiratorias, (arnip) que contiene la estructura arn oligo helicoidal, composicion que contiene la misma para prevencion o tratamiento de las enfermedades respiratorias.
|
|
US20160208247A1
(en)
|
2013-07-31 |
2016-07-21 |
Qbi Enterprises Ltd. |
Methods of use of sphingolipid polyalkylamine oligonucleotide compounds
|
|
US9790506B2
(en)
|
2013-10-02 |
2017-10-17 |
The Regents Of The University Of California |
Diagnostic and screening methods for atopic dermatitis
|
|
US8980273B1
(en)
|
2014-07-15 |
2015-03-17 |
Kymab Limited |
Method of treating atopic dermatitis or asthma using antibody to IL4RA
|
|
US20170226507A1
(en)
|
2014-05-05 |
2017-08-10 |
The Brigham And Women's Hospital, Inc. |
Coordinate control of pathogenic signaling by the mir-130/301 family in pulmonary hypertension and fibroproliferative diseases
|
|
US9139648B1
(en)
|
2014-07-15 |
2015-09-22 |
Kymab Limited |
Precision medicine by targeting human NAV1.9 variants for treatment of pain
|
|
EP3929293A3
(en)
|
2015-04-03 |
2022-03-16 |
University Of Massachusetts |
Fully stabilized asymmetric sirna
|
|
JP7027303B2
(ja)
|
2015-07-27 |
2022-03-01 |
オリックス ファーマシューティカルズ,インコーポレーテッド |
メラニン産生を抑制するrna複合体
|
|
WO2017085550A1
(en)
|
2015-11-16 |
2017-05-26 |
Olix Pharmaceuticals, Inc. |
Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3
|
|
CA3022877A1
(en)
|
2016-02-02 |
2017-08-10 |
Olix Pharmaceuticals, Inc. |
Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb
|
|
KR102825946B1
(ko)
|
2016-02-02 |
2025-06-27 |
올릭스 주식회사 |
IL4Rα, TRPA1, 또는 F2RL1을 표적화하는 RNA 복합체를 사용한 아토피 피부염 및 천식의 치료
|
|
KR102339886B1
(ko)
|
2016-04-11 |
2021-12-17 |
올릭스 주식회사 |
연결 조직 성장 인자를 표적화하는 rna 복합체를 사용한 특발성 폐 섬유증의 치료 방법
|
|
KR101916652B1
(ko)
|
2016-06-29 |
2018-11-08 |
올릭스 주식회사 |
작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
|
|
JP7424728B2
(ja)
|
2017-02-10 |
2024-01-30 |
オリック パルマセゥティカルズ インコーポレイテッド |
Rna干渉のための長鎖の二本鎖rna
|