JP6139671B2 - 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途 - Google Patents

細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途 Download PDF

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JP6139671B2
JP6139671B2 JP2015513901A JP2015513901A JP6139671B2 JP 6139671 B2 JP6139671 B2 JP 6139671B2 JP 2015513901 A JP2015513901 A JP 2015513901A JP 2015513901 A JP2015513901 A JP 2015513901A JP 6139671 B2 JP6139671 B2 JP 6139671B2
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nucleic acid
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acid molecule
ctgf
lasirna
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JP2015518721A5 (enExample
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ソンウ ホン
ソンウ ホン
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Olix Pharmaceuticals Inc
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JP2015513901A 2012-05-22 2013-05-21 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途 Active JP6139671B2 (ja)

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KR10-2012-0053950 2012-05-22
KR20120053950 2012-05-22
PCT/KR2013/004463 WO2013176477A1 (ko) 2012-05-22 2013-05-21 세포 내 관통능을 가지는 rna 간섭을 유도하는 핵산 분자 및 그 용도

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JP2016250474A Division JP6629712B2 (ja) 2012-05-22 2016-12-26 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途

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JP2015518721A JP2015518721A (ja) 2015-07-06
JP2015518721A5 JP2015518721A5 (enExample) 2016-06-23
JP6139671B2 true JP6139671B2 (ja) 2017-05-31

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JP2016250474A Active JP6629712B2 (ja) 2012-05-22 2016-12-26 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途
JP2019031549A Active JP6999590B2 (ja) 2012-05-22 2019-02-25 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途

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JP2019031549A Active JP6999590B2 (ja) 2012-05-22 2019-02-25 細胞内貫通能を持ってｒｎａ干渉を誘導する核酸分子およびその用途

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US (3) US10125362B2 (enExample)
EP (2) EP3514236A1 (enExample)
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KR (2) KR101567576B1 (enExample)
CN (2) CN104755620B (enExample)
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KR102321426B1 (ko) * 2017-02-21 2021-11-05 올릭스 주식회사 남성형 탈모 표적 유전자의 발현을 억제하는 비대칭 siRNA
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
KR20190037166A (ko) * 2017-09-28 2019-04-05 올릭스 주식회사 결합 조직 성장 인자를 표적으로 하는 rna 복합체를 함유하는 노인성 황반변성의 예방 또는 치료용 약학 조성물
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TW202028465A (zh) * 2018-09-28 2020-08-01 美商阿尼拉製藥公司 甲狀腺素運載蛋白（ＴＴＲ）ｉＲＮＡ組成物及其治療或預防ＴＴＲ相關眼部疾病之使用方法
CN109402127B (zh) * 2018-09-29 2021-12-10 复旦大学附属眼耳鼻喉科医院 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用
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KR102321425B1 (ko) * 2019-01-18 2021-11-04 올릭스 주식회사 NRL(Neural retina leucine zipper)의 발현을 억제하는 비대칭 siRNA
KR102397455B1 (ko) * 2019-05-20 2022-05-13 올릭스 주식회사 PD-1의 발현을 억제하는 비대칭 siRNA
CA3149835A1 (en) 2019-08-09 2021-02-18 University Of Massachusetts Chemically modified oligonucleotides targeting snps
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
KR102757180B1 (ko) * 2019-11-22 2025-01-21 (주)바이오니아 Ctgf 유전자 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 섬유증 관련 질환 및 호흡기 관련 질환 예방 및 치료용 조성물
KR102259402B1 (ko) * 2020-06-04 2021-06-01 주식회사 아임뉴런바이오사이언스 개선된 안정성을 갖는 핵산 분자 및 이의 용도
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