JP2010503382A5 - - Google Patents
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- JP2010503382A5 JP2010503382A5 JP2009520964A JP2009520964A JP2010503382A5 JP 2010503382 A5 JP2010503382 A5 JP 2010503382A5 JP 2009520964 A JP2009520964 A JP 2009520964A JP 2009520964 A JP2009520964 A JP 2009520964A JP 2010503382 A5 JP2010503382 A5 JP 2010503382A5
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- -1 dimethoxytrityl groups Chemical group 0.000 description 2
- NAGJZTKCGNOGPW-UHFFFAOYSA-N dithiophosphoric acid Chemical class OP(O)(S)=S NAGJZTKCGNOGPW-UHFFFAOYSA-N 0.000 description 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/487,788 US20070173473A1 (en) | 2001-05-18 | 2006-07-17 | RNA interference mediated inhibition of proprotein convertase subtilisin Kexin 9 (PCSK9) gene expression using short interfering nucleic acid (siNA) |
| US86136906P | 2006-11-28 | 2006-11-28 | |
| PCT/US2007/073723 WO2008011431A2 (en) | 2006-07-17 | 2007-07-17 | Rna interference mediated inhibition of proprotein convertase subtilisin kexin 9 (pcsk9) gene expression using short interfering nucleic acid (sina) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010503382A JP2010503382A (ja) | 2010-02-04 |
| JP2010503382A5 true JP2010503382A5 (enExample) | 2010-03-25 |
Family
ID=38957565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009520964A Withdrawn JP2010503382A (ja) | 2006-07-17 | 2007-07-17 | 低分子干渉核酸（ｓｉＮＡ）を用いたプロタンパク質転換酵素サブチリシンケクシン９（ＰＣＳＫ９）遺伝子発現のＲＮＡ干渉媒介性阻害 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2052079A2 (enExample) |
| JP (1) | JP2010503382A (enExample) |
| CN (1) | CN102124107A (enExample) |
| AU (1) | AU2007275365A1 (enExample) |
| CA (1) | CA2658183A1 (enExample) |
| WO (1) | WO2008011431A2 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935812B2 (en) | 2002-02-20 | 2011-05-03 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
| US7404969B2 (en) | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| CA2597724A1 (en) | 2005-02-14 | 2007-08-02 | Sirna Therapeutics, Inc. | Cationic lipids and formulated molecular compositions containing them |
| ES2874149T3 (es) * | 2006-05-11 | 2021-11-04 | Alnylam Pharmaceuticals Inc | Composiciones y métodos para inhibir la expresión del gen PCSK9 |
| AU2007306361A1 (en) * | 2006-10-09 | 2008-04-17 | Santaris Pharma A/S | RNA antagonist compounds for the modulation of PCSK9 |
| US8093222B2 (en) | 2006-11-27 | 2012-01-10 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
| EP2453016A1 (en) | 2006-11-27 | 2012-05-16 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
| EP2245039A4 (en) * | 2008-01-31 | 2012-06-06 | Alnylam Pharmaceuticals Inc | OPTIMIZED METHODS FOR EXPORING DSRNA TO TARGET THE PCSK9 GEN |
| WO2009114475A2 (en) * | 2008-03-09 | 2009-09-17 | Intradigm Corporation | Compositions comprising human pcsk9 and apolipoprotein b sirna and methods of use |
| WO2009127680A1 (en) * | 2008-04-16 | 2009-10-22 | Santaris Pharma A/S | Pharmaceutical composition comprising anti pcsk9 oligomers |
| CA2635187A1 (en) * | 2008-06-05 | 2009-12-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Oligonucleotide duplexes and uses thereof |
| WO2010026537A1 (en) | 2008-09-05 | 2010-03-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Novel multimodular assembly useful for intracellular delivery |
| WO2010147992A1 (en) | 2009-06-15 | 2010-12-23 | Alnylam Pharmaceuticals, Inc. | Methods for increasing efficacy of lipid formulated sirna |
| NZ597504A (en) | 2009-06-15 | 2013-10-25 | Alnylam Pharmaceuticals Inc | Lipid formulated dsrna targeting the pcsk9 gene |
| WO2011009697A1 (en) | 2009-07-21 | 2011-01-27 | Santaris Pharma A/S | Antisense oligomers targeting pcsk9 |
| US9187746B2 (en) | 2009-09-22 | 2015-11-17 | Alnylam Pharmaceuticals, Inc. | Dual targeting siRNA agents |
| SG10201407996PA (en) * | 2009-12-23 | 2015-01-29 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| CN103703141B (zh) | 2011-04-08 | 2016-08-17 | 伯乐实验室公司 | 具有降低的非特异性活性的pcr反应混合物 |
| SI3366775T2 (sl) * | 2011-11-18 | 2025-12-31 | Alnylam Pharmaceuticals, Inc. | Modificirana sredstva RNAI |
| JP6002382B2 (ja) * | 2011-12-07 | 2016-10-05 | 株式会社バイオシンクタンク | 遺伝子発現阻害剤及び阻害方法 |
| EP2667197B1 (en) * | 2012-05-25 | 2015-09-16 | Zora Biosciences OY | Sensitive efficacy and specificity biomarkers for proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition |
| PT2929031T (pt) * | 2012-12-05 | 2018-01-19 | Alnylam Pharmaceuticals Inc | Composições de irna de pcsk9 e métodos de seu uso |
| JP6255092B2 (ja) | 2013-06-27 | 2017-12-27 | ロシュ イノベーション センター コペンハーゲン エーエス | Ｐｃｓｋ９を標的とするアンチセンスオリゴマーおよびコンジュゲート |
| US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
| FR3014695A1 (enExample) * | 2013-12-17 | 2015-06-19 | Kymab Ltd | |
| US9045548B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment |
| US9051378B1 (en) | 2014-07-15 | 2015-06-09 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US9034332B1 (en) | 2014-07-15 | 2015-05-19 | Kymab Limited | Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment |
| US9023359B1 (en) | 2014-07-15 | 2015-05-05 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US8883157B1 (en) | 2013-12-17 | 2014-11-11 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US9139648B1 (en) | 2014-07-15 | 2015-09-22 | Kymab Limited | Precision medicine by targeting human NAV1.9 variants for treatment of pain |
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| EP3974530A4 (en) * | 2019-05-22 | 2023-07-12 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, METHOD FOR PREPARATION AND USE |
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| WO2023284763A1 (zh) * | 2021-07-16 | 2023-01-19 | 苏州瑞博生物技术股份有限公司 | 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060148743A1 (en) * | 2001-05-18 | 2006-07-06 | Vasant Jadhav | RNA interference mediated inhibition of histone deacetylase (HDAC) gene expression using short interfering nucleic acid (siNA) |
| US20070173473A1 (en) * | 2001-05-18 | 2007-07-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of proprotein convertase subtilisin Kexin 9 (PCSK9) gene expression using short interfering nucleic acid (siNA) |
| GB2417727B (en) * | 2003-06-13 | 2008-01-16 | Alnylam Europe Ag | Double-stranded ribonucleic acid with increased effectiveness in an organism |
| US20090130691A1 (en) * | 2005-09-16 | 2009-05-21 | Institut De Recherches Cliniques De Montreal | Screening proteinase modulators using a chimeric protein and ski-i proprotein convertase substrates and inhibitors |
| JP5731115B2 (ja) * | 2006-05-05 | 2015-06-10 | アイシス ファーマシューティカルズ， インコーポレーテッド | 遺伝子発現を調節するための化合物および方法 |
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2007
- 2007-07-17 WO PCT/US2007/073723 patent/WO2008011431A2/en not_active Ceased
- 2007-07-17 CN CN2007800269961A patent/CN102124107A/zh active Pending
- 2007-07-17 CA CA002658183A patent/CA2658183A1/en not_active Abandoned
- 2007-07-17 AU AU2007275365A patent/AU2007275365A1/en not_active Abandoned
- 2007-07-17 JP JP2009520964A patent/JP2010503382A/ja not_active Withdrawn
- 2007-07-17 EP EP07813032A patent/EP2052079A2/en not_active Withdrawn
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