JP2016129515A5 - - Google Patents

Download PDF

Info

Publication number
JP2016129515A5
JP2016129515A5 JP2016027812A JP2016027812A JP2016129515A5 JP 2016129515 A5 JP2016129515 A5 JP 2016129515A5 JP 2016027812 A JP2016027812 A JP 2016027812A JP 2016027812 A JP2016027812 A JP 2016027812A JP 2016129515 A5 JP2016129515 A5 JP 2016129515A5
Authority
JP
Japan
Prior art keywords
protein
cells
tat
tat protein
proliferation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016027812A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016129515A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2016129515A publication Critical patent/JP2016129515A/ja
Publication of JP2016129515A5 publication Critical patent/JP2016129515A5/ja
Pending legal-status Critical Current

Links

JP2016027812A 2005-10-18 2016-02-17 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。 Pending JP2016129515A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72813105P 2005-10-18 2005-10-18
US60/728,131 2005-10-18
US76599306P 2006-02-06 2006-02-06
US60/765,993 2006-02-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2014108137A Division JP6302356B2 (ja) 2005-10-18 2014-05-26 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017166334A Division JP6655050B2 (ja) 2005-10-18 2017-08-31 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。

Publications (2)

Publication Number Publication Date
JP2016129515A JP2016129515A (ja) 2016-07-21
JP2016129515A5 true JP2016129515A5 (enExample) 2016-09-01

Family

ID=37963171

Family Applications (8)

Application Number Title Priority Date Filing Date
JP2008536713A Pending JP2009511081A (ja) 2005-10-18 2006-10-18 条件的に不死化された長期幹細胞およびそのような細胞を作製および使用する方法
JP2012221023A Expired - Fee Related JP5726148B2 (ja) 2005-10-18 2012-10-03 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2014108137A Expired - Fee Related JP6302356B2 (ja) 2005-10-18 2014-05-26 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2016027812A Pending JP2016129515A (ja) 2005-10-18 2016-02-17 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2017166334A Expired - Fee Related JP6655050B2 (ja) 2005-10-18 2017-08-31 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2019006759A Expired - Fee Related JP6797221B2 (ja) 2005-10-18 2019-01-18 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2020119082A Active JP7078673B2 (ja) 2005-10-18 2020-07-10 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2022025236A Pending JP2022065146A (ja) 2005-10-18 2022-02-22 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2008536713A Pending JP2009511081A (ja) 2005-10-18 2006-10-18 条件的に不死化された長期幹細胞およびそのような細胞を作製および使用する方法
JP2012221023A Expired - Fee Related JP5726148B2 (ja) 2005-10-18 2012-10-03 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2014108137A Expired - Fee Related JP6302356B2 (ja) 2005-10-18 2014-05-26 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2017166334A Expired - Fee Related JP6655050B2 (ja) 2005-10-18 2017-08-31 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2019006759A Expired - Fee Related JP6797221B2 (ja) 2005-10-18 2019-01-18 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2020119082A Active JP7078673B2 (ja) 2005-10-18 2020-07-10 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
JP2022025236A Pending JP2022065146A (ja) 2005-10-18 2022-02-22 条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。

Country Status (12)

Country Link
US (7) US8883507B2 (enExample)
EP (1) EP1942739B1 (enExample)
JP (8) JP2009511081A (enExample)
KR (2) KR101441843B1 (enExample)
CN (2) CN101330830B (enExample)
AT (1) ATE491022T1 (enExample)
AU (1) AU2006304392B2 (enExample)
CA (2) CA2626525C (enExample)
DE (1) DE602006018768D1 (enExample)
IL (7) IL286053B2 (enExample)
IN (1) IN2014DN06624A (enExample)
WO (1) WO2007047583A2 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007047583A2 (en) 2005-10-18 2007-04-26 National Jewish Medical And Research Center Conditionally immortalized long-term stem cells and methods of making and using such cells
SI2772535T1 (sl) 2006-05-31 2022-08-31 Children's Medical Center Corporation ABC5 pozitivne mezenhimske matične celice kot imunomodulatorji
GB0619500D0 (en) * 2006-10-03 2006-11-08 Univ Keele Treatment of fibrosis
EP2583550A1 (en) * 2007-03-13 2013-04-24 National Jewish Health Methods for generation of antibodies
KR101803099B1 (ko) 2008-05-16 2017-11-30 타이가 바이오테크놀로지스, 인코포레이티드 항체 및 그 제조 방법
AU2009274172B2 (en) 2008-07-21 2015-08-13 Htyr Acquisition Llc Differentiated anucleated cells and method for preparing the same
CN104353066B (zh) * 2008-08-28 2017-05-10 泰加生物工艺学公司 Myc的调节剂、其使用方法和鉴别调节myc的试剂的方法
EP3734281A3 (en) 2008-11-14 2021-01-27 The Brigham and Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
EP2448967B1 (en) * 2009-06-29 2015-04-15 Ilya B. Leskov Non-human mammal model of human hematopoietic cancer
AU2014240253B2 (en) * 2009-09-15 2017-08-03 The University Of Tokyo Novel Method for Producing Differentiated Cells
KR101834687B1 (ko) * 2009-09-15 2018-03-05 고쿠리츠다이가쿠호우진 도쿄다이가쿠 분화 세포의 신규 제조법
DK2498796T3 (en) 2009-11-09 2018-03-05 Aal Scient Inc HEART DISEASE TREATMENT
JP2013528368A (ja) * 2010-05-06 2013-07-11 ステム セル メディスン リミテッド 個の医療のための幹細胞バンク
WO2012043651A1 (ja) * 2010-09-30 2012-04-05 国立大学法人 熊本大学 ミエロイド系血液細胞の製造方法
US8889630B2 (en) 2011-12-23 2014-11-18 Carlos Lopez Method for hair regrowth using Granulocyte-Colony Stimulating Factor
US20130171115A1 (en) * 2011-12-30 2013-07-04 Gang Li Cell-mediated gene therapy for cancer using mesenchymal stem cells expressing a suicide gene
DK2877189T3 (da) 2012-07-20 2021-02-22 Taiga Biotechnologies Inc Forbedret rekonstituering og autorekonstituering af det hæmopoietiske kammer
EP2964238B1 (en) 2013-02-19 2021-01-13 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
US9365825B2 (en) 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
MX378814B (es) 2013-05-10 2025-03-11 Childrens Medical Center Armazón de colágeno y glicosaminoglicano coinjertado con una población de células madre abcb5+ y usos del mismo.
KR101638403B1 (ko) * 2013-07-17 2016-07-11 아주대학교산학협력단 RGMc를 유효성분으로 포함하는 줄기세포 유도용 배지 조성물 및 이를 이용한 줄기세포의 유도방법
WO2015020993A2 (en) * 2013-08-05 2015-02-12 The Trustees Of The University Of Pennsylvania RNAi COMPOSITIONS AND METHODS FOR TREATMENT OF FRIEDREICH'S ATAXIA
CN103509101B (zh) * 2013-08-12 2016-11-02 中国科学院广州生物医药与健康研究院 一种扩增脐带血造血干细胞的细胞因子及其培养基
WO2016149672A1 (en) 2015-03-18 2016-09-22 The Regents Of The University Of California Methods of preventing and reversing stem cell aging
CN106148266A (zh) * 2015-04-20 2016-11-23 烟台赛泽生物技术有限公司 一种免疫细胞用培养基及该培养基的添加剂
CN104928247B (zh) * 2015-07-02 2018-03-23 广州赛莱拉干细胞科技股份有限公司 一种神经干细胞培养基及神经干细胞贴壁培养方法
CN108135935A (zh) * 2015-07-21 2018-06-08 儿童医疗中心有限公司 表达pd-l1的造血干细胞及其用途
SG10201913151TA (en) 2015-09-09 2020-03-30 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Genetic engineering of macrophages for immunotherapy
US11534466B2 (en) 2016-03-09 2022-12-27 Aal Scientifics, Inc. Pancreatic stem cells and uses thereof
CN105695511B (zh) * 2016-04-13 2025-01-21 中国人民解放军第三军医大学 一种永生化毛囊干细胞系及其制备方法
CN105713880A (zh) * 2016-04-20 2016-06-29 广东艾时代生物科技有限责任公司 一种造血干细胞体外扩增培养的无血清培养基及其应用
CN106279403B (zh) * 2016-08-16 2019-06-11 长春市海兰深生物医学技术有限公司 一种检测天然肺癌相关抗体的组合物、试剂盒和方法
IL281425B (en) 2016-12-02 2022-07-01 Taiga Biotechnologies Inc Nanoparticle formulations
CN106754728B (zh) * 2016-12-30 2020-05-15 中国人民解放军总医院 后肾间充质细胞系及其制备方法与应用
FR3068366B1 (fr) * 2017-06-30 2023-11-24 Francais Du Sang Ets Procede de production de progeniteurs erythroides
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
US20200155600A1 (en) * 2017-08-03 2020-05-21 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of cancer
US11879137B2 (en) 2017-09-22 2024-01-23 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
US12023357B2 (en) 2017-10-13 2024-07-02 Hackensack University Medical Center Rejuvenated aged hematopoietic stem cells and methods of use
CN107937342B (zh) * 2017-11-06 2021-07-06 中国人民解放军第四军医大学 一种通过内皮细胞来源的外泌体扩增神经干细胞的方法
CN108070567A (zh) * 2018-01-19 2018-05-25 皓昇莱生物制药有限公司 一种永生化的尿液来源细胞株及其构建方法
EP3784249A4 (en) 2018-04-25 2022-03-02 Children's Medical Center Corporation ABCB5 LIGANDS AND SUBSTRATES
US20210371828A1 (en) * 2018-10-12 2021-12-02 Reneuron Limited Induced pluripotent cell comprising a controllable transgene for conditional immortalization
GB201902068D0 (en) * 2019-02-14 2019-04-03 Cambridge Entpr Ltd Methods of reactivating proliferative capacity non-proliferative tissues
US12250943B2 (en) 2019-04-08 2025-03-18 Htyr Acquisition Llc Compositions and methods for the cryopreservation of immune cells
US12370217B2 (en) 2019-05-14 2025-07-29 Htyr Acquisition Llc Compositions and methods for treating T cell exhaustion
WO2021015584A1 (ko) * 2019-07-24 2021-01-28 주식회사 에스엘바이젠 불사화된 줄기세포주의 제조 방법 및 이의 용도
CN110622921B (zh) * 2019-09-29 2021-06-15 江苏大学 阿尔茨海默病病变区FoxG1过表达小鼠模型的构建方法及应用
GB202005494D0 (en) * 2020-04-15 2020-05-27 Reneuron Ltd Induced pluripotent cell comprising a contollable transgene for conditional immortalisation
KR20220057859A (ko) 2020-10-30 2022-05-09 전상수 펜터리
US20230407268A1 (en) 2020-11-06 2023-12-21 Trans Chromosomics, Inc. Method for producing reversibly immortalized cell
CN113444730A (zh) * 2021-03-17 2021-09-28 昆明市延安医院 一种原发性肝细胞klotho基因转导干细胞筛选构建方法
WO2023277153A1 (ja) * 2021-06-30 2023-01-05 国立大学法人千葉大学 骨髄系共通前駆細胞(cmp)又は骨髄球系前駆細胞の増殖性を向上させる方法
CN113583965A (zh) * 2021-08-05 2021-11-02 大连干细胞与精准医学创新研究院 一种条件永生化人神经干细胞来源细胞膜纳米囊泡制剂及其制备方法和应用
WO2023069881A1 (en) * 2021-10-20 2023-04-27 University Of Rochester Treatment with genetically modified cells, and genetically modified cells per se, with increased competitive advantage and/or decreased competitive disadvantage
WO2023190271A1 (ja) 2022-03-28 2023-10-05 株式会社リジェネシスサイエンス miR-140を含む医薬組成物及びその製造方法

Family Cites Families (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
EP0207147A4 (en) * 1984-12-21 1988-07-14 Techniclone Res Partners METHOD OF ELECTRICAL IMMORTALIZATION OF LYMPHOID CELLS.
DE3531430A1 (de) 1985-09-03 1987-03-05 Biotest Pharma Gmbh Verfahren zur gewinnung von komponenten aus einer fluessigkeit mit in raeumlich getrennten bereichen vorliegenden komponenten
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4900322A (en) 1986-09-22 1990-02-13 Adams James D Blood component pooling valve and kit
US5476996A (en) 1988-06-14 1995-12-19 Lidak Pharmaceuticals Human immune system in non-human animal
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
US5804604A (en) 1989-12-21 1998-09-08 Biogen, Inc. Tat-derived transport polypeptides and fusion proteins
US5670617A (en) 1989-12-21 1997-09-23 Biogen Inc Nucleic acid conjugates of tat-derived transport polypeptides
US5849288A (en) 1990-01-15 1998-12-15 Yeda Research And Development Co. Ltd. Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
IE920716A1 (en) 1991-03-07 1992-09-09 Gen Hospital Corp Redirection of cellular immunity by receptor chimeras
US6004811A (en) 1991-03-07 1999-12-21 The Massachussetts General Hospital Redirection of cellular immunity by protein tyrosine kinase chimeras
US5843728A (en) 1991-03-07 1998-12-01 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US6753162B1 (en) 1991-03-07 2004-06-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US5851828A (en) 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US5912170A (en) 1991-03-07 1999-06-15 The General Hospital Corporation Redirection of cellular immunity by protein-tyrosine kinase chimeras
AU781922B2 (en) 1991-12-17 2005-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5289858A (en) 1991-12-18 1994-03-01 Abbott Laboratories System for accommodating withdrawal of liquid from a bulk supply
US8211422B2 (en) 1992-03-18 2012-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric receptor genes and cells transformed therewith
CA2135642C (en) 1992-08-21 1999-12-14 James G. Barsoum Tat-derived transport polypeptides
US5580760A (en) 1993-02-22 1996-12-03 The United States Of America As Represented By The Department Of Health And Human Services FUSE binding protein and cDNA therefor
CA2167580A1 (en) 1993-07-22 1995-02-02 Howard Y. Chen Expression of human interleukin-1.beta. in a transgenic animal
US5599705A (en) 1993-11-16 1997-02-04 Cameron; Robert B. In vitro method for producing differentiated universally compatible mature human blood cells
AU683158B2 (en) 1994-03-03 1997-10-30 Alexion Pharmaceuticals, Inc. Terminal complement inhibitor fusion genes and proteins
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US6713247B1 (en) * 1996-09-03 2004-03-30 Signal Pharmaceuticials, Inc. Human CNS cell lines and methods of use therefor
BR9809138A (pt) 1997-05-21 2001-08-28 Trustees For The Leland Stanfo Conjugado e método para aumentar o transporte de um composto selecionado atravessando uma membrana biológica
EP0893493A3 (de) 1997-07-21 2002-12-04 Aventis Pharma Deutschland GmbH Genetisch veränderte Zellen und deren Verwendung in der Prophylaxe oder Therapie von Erkrankungen
GB9720585D0 (en) * 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine
AU1818299A (en) 1997-12-10 1999-06-28 Washington University Anti-pathogen system and methods of use thereof
ATE288477T1 (de) 1998-04-08 2005-02-15 Shionogi & Co Verfahren um vorläuferzellen von osteoklasten zu isolieren und ihre differenzierung in osteoklasten zu induzieren.
US6835567B1 (en) 1998-04-14 2004-12-28 Signal Pharmaceuticals, Inc. PNS cell lines and methods of use therefor
US6451558B1 (en) 1998-08-03 2002-09-17 Novartis Ag Genes in the control of hematopoiesis
US6913925B1 (en) 1998-08-12 2005-07-05 Signal Pharmaceuticals Llc Human mesencephalon cell lines and methods of use therefor
WO2000062067A1 (en) 1999-02-28 2000-10-19 Washington University Novel transduction molecules and methods for using same
WO2000059540A1 (en) 1999-04-05 2000-10-12 Biocrystal Ltd. Assay kits and methods for immune complex-mediated activation involving shed antigens
US6358739B1 (en) 1999-04-12 2002-03-19 Modex Therapeutiques, S.A. Transiently immortalized cells
US6451601B1 (en) * 1999-04-12 2002-09-17 Modex Therapeutiques, S.A. Transiently immortalized cells for use in gene therapy
EP1175436B1 (en) * 1999-04-12 2006-10-11 Heart Biosystems GmbH Transiently immortalized cells for use in gene therapy
US7135287B1 (en) 1999-10-02 2006-11-14 Biosite, Inc. Human antibodies
US7311920B1 (en) 1999-10-08 2007-12-25 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
EP1228233B1 (en) * 1999-11-10 2007-01-10 Rigel Pharmaceuticals, Inc. Methods and compositions comprising renilla gfp
EP1103615A1 (en) 1999-11-25 2001-05-30 Universite De Geneve Vectors capable of immortalizing non-dividing cells and cells immortalized with said vectors
US20010049393A1 (en) 1999-12-07 2001-12-06 Whitehead Institute For Biomedical Research Methods for defining MYC target genes and uses thereof
AU2001256746A1 (en) 2000-05-15 2001-11-26 Sonoko Habu Chimeric mouse having immunity constructed by using human cd34-positive cells and use thereof
US20020155127A1 (en) * 2000-06-02 2002-10-24 Danher Wang Genetic vaccine against human immunodeficiency virus
US20030072794A1 (en) 2000-06-09 2003-04-17 Teni Boulikas Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes
US20070248618A1 (en) 2004-03-16 2007-10-25 Cohen David I Tat-Based vaccine Compositions and Methods of Making and Using Same
ATE428790T1 (de) 2000-09-25 2009-05-15 Genetronics Inc Verbessertes system zur regulation der transgenexpression
JP2004521616A (ja) 2000-10-30 2004-07-22 カロバイオス, インコーポレイテッド 競合的選択による親和性成熟
JP2004528012A (ja) 2000-11-01 2004-09-16 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ 改善された免疫応答を誘導し得る発現ベクターおよびこのベクターの使用方法
EP1338198B1 (en) 2000-12-01 2007-11-28 Central Institute For Experimental Animals Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse
WO2002057436A2 (en) 2001-01-19 2002-07-25 Gendel Limited Red blood cell from a transgenic animal as vehicle for polypeptide delivery
US7033744B2 (en) 2001-03-16 2006-04-25 Naoya Kobayashi Method for proliferating a liver cell, a liver cell obtained thereby, and use thereof
WO2002097050A2 (en) * 2001-05-31 2002-12-05 Novartis Ag Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions
AU2002321581C1 (en) 2001-08-31 2008-09-18 Adaptimmune Limited Soluble T cell receptor
CN1408850A (zh) * 2001-09-18 2003-04-09 王虹 人血树突状细胞永生化技术
CN100506978C (zh) 2001-09-21 2009-07-01 中国人民解放军军事医学科学院野战输血研究所 一种新的造血干/祖细胞的富集方法及其体外定向诱导分化
GB0124391D0 (en) 2001-10-11 2001-11-28 Gene Expression Technologies L Control of gene expression
US20030147887A1 (en) 2001-11-02 2003-08-07 Shen-Wu Wang B-cell lymphoma specific antigen for use in diagnosis and treatment of B-cell malignancies
EP1321034A1 (en) * 2001-12-21 2003-06-25 Pfizer Products Inc. Disruption of the phosphodieterase 10 gene
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
US7670781B2 (en) 2002-01-03 2010-03-02 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an agent that provides a primary activation signal and another agent that provides a co-stimulatory signal
CA2476556A1 (en) 2002-02-13 2003-08-21 Duke University Modulation of immune response by non-peptide binding stress response polypeptides
CN1240439C (zh) 2002-03-28 2006-02-08 南京凯基生物科技发展有限公司 肿瘤基因开关药物
US7211191B2 (en) 2004-09-30 2007-05-01 Thermogenesis Corp. Blood component separation method and apparatus
NZ536548A (en) 2002-04-16 2007-11-30 Dana Farber Cancer Inst Inc Using stem cells to make chimeric non-human animals having tumors or the ability to develop tumors
GB2387599B (en) 2002-04-17 2005-08-10 Jason Peter Brown Methods for producing antibodies
CN105566497A (zh) 2002-05-10 2016-05-11 新世纪药品有限公司 融合铁蛋白在疫苗和其他方面的应用
DE60323407D1 (de) * 2002-05-16 2008-10-16 Bavarian Nordic As Fusionsprotein des regulatorische/akzessorische HIV Proteine
CA2485939C (en) * 2002-05-29 2013-10-29 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
US8034334B2 (en) 2002-09-06 2011-10-11 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy
AU2003271904B2 (en) 2002-10-09 2009-03-05 Adaptimmune Limited Single chain recombinant T cell receptors
ES2279849T3 (es) 2002-10-11 2007-09-01 Imvision Gmbh Moleculas transportadoras de antigenos modulares (moleculas mat) para la modulacion de reacciones inmunitarias, constructos, procedimientos y usos de las mismas.
WO2004035535A2 (en) 2002-10-15 2004-04-29 Yeda Research And Development Co. Ltd. Erythrocyte differentiation factor, gene encoding same, and methods of use thereof
ES2327229T3 (es) 2002-11-09 2009-10-27 Immunocore Ltd. Presentacion del receptor de linfocitos t.
US20060247192A1 (en) 2002-12-05 2006-11-02 Jenkinson John D Control of apoptosis
GB0304068D0 (en) 2003-02-22 2003-03-26 Avidex Ltd Substances
US7482016B2 (en) 2003-03-19 2009-01-27 The J. David Gladstone Institutes Immunogenic compositions comprising HIV-1 acetylated Tat polypeptides
US20040224402A1 (en) 2003-05-08 2004-11-11 Xcyte Therapies, Inc. Generation and isolation of antigen-specific T cells
WO2005014785A2 (en) 2003-06-18 2005-02-17 The George Washington University Conditionally-immortalized hematopoietic progenitor cell lines
CA2529752A1 (en) 2003-06-20 2005-09-15 The Regents Of The University Of California Polypeptide transduction and fusogenic peptides
IL161903A0 (en) 2003-07-17 2005-11-20 Gamida Cell Ltd Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
US7705049B2 (en) 2004-01-21 2010-04-27 New York University Methods for treating non-melanoma cancers with PABA
JP2005232148A (ja) * 2004-02-03 2005-09-02 Technion Research & Development Foundation Ltd 神経保護剤としてプロパルギルアミンの使用
ATE417065T1 (de) 2004-05-19 2008-12-15 Medigene Ltd Hochaffiner ny-eso-t-zellen-rezeptor
DE602005009825D1 (de) 2004-05-19 2008-10-30 Medigene Ltd Verfahren zur verbesserung von t-zellrezeptoren
WO2006000830A2 (en) 2004-06-29 2006-01-05 Avidex Ltd Cells expressing a modified t cell receptor
US20060068469A1 (en) 2004-08-17 2006-03-30 Research Development Foundation Bacterial vector systems
GB0420963D0 (en) * 2004-09-21 2004-10-20 Reneuron Ltd Hepatocyte
US7767453B2 (en) * 2004-10-20 2010-08-03 Whitehead Institute For Biomedical Research Cultured hematopoietic stem cells and method for expansion and analysis thereof
WO2007067183A1 (en) 2005-12-09 2007-06-14 The Regents Of The University Of California Derivation of unlimited quantities of neutrophils or monocyte/dendritic cells
US20060156422A1 (en) 2005-01-10 2006-07-13 Medical Research Council Methods and compositions for the generation of antibodies
JP2008535823A (ja) 2005-03-25 2008-09-04 キュラジェン コーポレイション テネイシンの主要な抗原に対する抗体
WO2006116512A1 (en) 2005-04-26 2006-11-02 The Board Of Trustees Of The University Of Illinois, Urbana, Il Nucleoside compounds and methods of use thereof
EP1885754B1 (en) 2005-05-25 2011-02-09 Immunocore Ltd. T cell receptors which specifically bind to vygfvracl-hla-a24
EP2056800B1 (en) 2005-08-26 2015-12-09 The Board Of Trustees Of The Leland Stanford Junior University Therapy procedure for drug delivery for trigeminal pain
US20070047583A1 (en) 2005-08-29 2007-03-01 Siemens Aktiengesellschaft Method for using a short address in a packet header
WO2007047583A2 (en) 2005-10-18 2007-04-26 National Jewish Medical And Research Center Conditionally immortalized long-term stem cells and methods of making and using such cells
US7582745B2 (en) 2005-11-04 2009-09-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of Nav1.8 gene
EP1792627A1 (en) 2005-12-05 2007-06-06 ImVisioN AG Modulation of the immune response by administration of intralymphatic transduction allergen (ITAG-)-molecules
WO2008039818A2 (en) 2006-09-26 2008-04-03 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Modified t cell receptors and related materials and methods
EP2087000A2 (en) 2006-09-29 2009-08-12 Immunocore Ltd. T cell therapies
EP2583550A1 (en) 2007-03-13 2013-04-24 National Jewish Health Methods for generation of antibodies
US20110218210A1 (en) 2007-11-02 2011-09-08 Taiga Biotechnologies Compounds for treating abnormal cellular proliferation
CN102027105B (zh) 2008-03-17 2015-03-11 斯克里普斯研究所 用于产生诱导的多能干细胞的组合化学遗传方法
KR101803099B1 (ko) 2008-05-16 2017-11-30 타이가 바이오테크놀로지스, 인코포레이티드 항체 및 그 제조 방법
US8481492B2 (en) 2008-06-13 2013-07-09 Life & Brain Gmbh Fusion protein and use thereof
AU2009274172B2 (en) 2008-07-21 2015-08-13 Htyr Acquisition Llc Differentiated anucleated cells and method for preparing the same
CN104353066B (zh) 2008-08-28 2017-05-10 泰加生物工艺学公司 Myc的调节剂、其使用方法和鉴别调节myc的试剂的方法
CN107630001A (zh) 2008-11-06 2018-01-26 印第安纳大学研究与技术公司 增强造血干细胞植入过程的材料和方法
CN102272153B (zh) 2008-11-24 2015-04-15 德国慕尼黑亥姆霍兹研究中心健康和环境有限公司 高亲和力t细胞受体及其应用
WO2011100477A2 (en) 2010-02-10 2011-08-18 Taiga Biotechnologies, Inc. Antibodies and processes for preparing the same
US20120107317A1 (en) 2010-10-27 2012-05-03 The University Of Hong Kong Use of cytoplasmic c-myc for regulating immune responses
US20120244133A1 (en) 2011-03-22 2012-09-27 The United States of America, as represented by the Secretary, Department of Health and Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
EP3766896B1 (en) 2011-09-15 2025-11-05 The United States of America, as represented by The Secretary, Department of Health and Human Services T cell receptors recognizing hla-a1- or hla-cw7-restricted mage
CN107557334B (zh) 2012-05-03 2021-06-25 弗雷德哈钦森癌症研究中心 增强亲和力的t细胞受体及其制备方法
DE102012209673A1 (de) 2012-06-08 2013-12-24 Artcline Gmbh Verfahren zum Herstellen einer Leukozytenpräparation und Leukozytenpräparation
DK2877189T3 (da) 2012-07-20 2021-02-22 Taiga Biotechnologies Inc Forbedret rekonstituering og autorekonstituering af det hæmopoietiske kammer
MX2015000979A (es) 2012-07-27 2015-11-23 Univ Illinois Ingenieria de receptores de celulas t.
US20140109246A1 (en) 2012-09-24 2014-04-17 The Regents Of The University Of Colorado, A Body Corporate Methods of generating xenochimaeric mice with tumor and hematopoietic system from the same heterologous species
GB2508414A (en) 2012-11-30 2014-06-04 Max Delbrueck Centrum Tumour specific T cell receptors (TCRs)
CN105163745B (zh) 2013-03-01 2020-06-12 美国卫生和人力服务部 从外周血中产生肿瘤反应性t细胞富集群的方法
RU2671897C2 (ru) 2013-03-01 2018-11-07 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Способы получения из опухоли обогащенных популяций реактивных в отношении опухоли т-клеток
US9365825B2 (en) 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
AU2015249371B2 (en) 2014-04-24 2020-04-30 Board Of Regents, The University Of Texas System Application of induced pluripotent stem cells to generate adoptive cell therapy products
KR102582035B1 (ko) 2014-12-24 2023-09-22 넥스이뮨, 인크. 면역요법을 위한 나노입자 조성물 및 방법
EP3402814B1 (en) 2016-01-15 2021-04-21 Berkeley Lights, Inc. Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma

Similar Documents

Publication Publication Date Title
JP2016129515A5 (enExample)
Palechor-Ceron et al. Conditional reprogramming for patient-derived cancer models and next-generation living biobanks
JP2018520654A5 (enExample)
JP2018518943A5 (enExample)
MY189819A (en) Genetically modified cells and uses thereof
JP2018508198A5 (enExample)
Al Ameri et al. Cell type-specific TGF-β mediated EMT in 3D and 2D models and its reversal by TGF-β receptor kinase inhibitor in ovarian cancer cell lines
WO2015188106A3 (en) Perfusion culturing methods and uses thereof
JP2016527891A5 (enExample)
EP4306636A3 (en) Monolayer of pbmcs or bone-marrow cells and uses thereof
JP2016500260A5 (enExample)
Lin et al. Bovine induced pluripotent stem cells are more resistant to apoptosis than testicular cells in response to mono-(2-ethylhexyl) phthalate
Kaldre et al. A preliminary study on the tolerance of marble crayfish Procambarus fallax f. virginalis to low temperature in nordic climate
Loiben et al. Cardiomyocyte apoptosis is associated with contractile dysfunction in stem cell model of MYH7 E848G hypertrophic cardiomyopathy
Giallongo et al. Engagement of Mesenchymal stromal cells in the remodeling of the bone marrow microenvironment in hematological cancers
Tang et al. Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal
Glauß et al. A novel chimeric oncolytic virus mediates a multifaceted cellular immune response in a syngeneic B16 melanoma model
Iordache et al. Histone deacetylase (HDAC) inhibitors down-regulate endothelial lineage commitment of umbilical cord blood derived endothelial progenitor cells
Gao et al. Efficient reprogramming of mouse embryonic stem cells into trophoblast stem-like cells via Lats kinase inhibition
JP2010166901A5 (enExample)
JP2015073442A5 (enExample)
Brovko et al. The integration of economy and pedagogy in educational activities
WO2016193986A3 (en) Selective surfaces for, and methods of, selecting a population of stem and progenitor cells, and uses thereof
Krüger et al. Functional genomic screening in human pluripotent stem cells reveals new roadblocks in early pancreatic endoderm formation
Bojorge-García et al. The ecological importance of algae in rivers