JP2025004002A5 - - Google Patents
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- JP2025004002A5 JP2025004002A5 JP2024159834A JP2024159834A JP2025004002A5 JP 2025004002 A5 JP2025004002 A5 JP 2025004002A5 JP 2024159834 A JP2024159834 A JP 2024159834A JP 2024159834 A JP2024159834 A JP 2024159834A JP 2025004002 A5 JP2025004002 A5 JP 2025004002A5
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- JP
- Japan
- Prior art keywords
- amino acid
- seq
- variant
- terminus
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100021102 Hyaluronidase PH-20 Human genes 0.000 claims 20
- 101150055528 SPAM1 gene Proteins 0.000 claims 20
- 125000000539 amino acid group Chemical group 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 238000012217 deletion Methods 0.000 claims 8
- 230000037430 deletion Effects 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 8
- 238000003259 recombinant expression Methods 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- -1 T475 Substances 0.000 claims 2
- 239000003996 polyglycerol polyricinoleate Substances 0.000 claims 2
- 239000001957 sucroglyceride Substances 0.000 claims 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20180086308 | 2018-07-25 | ||
| KR10-2018-0086308 | 2018-07-25 | ||
| KR10-2019-0029758 | 2019-03-15 | ||
| KR20190029758 | 2019-03-15 | ||
| PCT/KR2019/009215 WO2020022791A1 (ko) | 2018-07-25 | 2019-07-25 | 신규 히알루론산 가수분해 효소 변이체 및 이를 포함하는 약제학적 조성물 |
| JP2020500863A JP7204729B2 (ja) | 2018-07-25 | 2019-07-25 | 新規なヒアルロン酸加水分解酵素変異体およびそれを含む薬学組成物 |
| JP2022211105A JP2023052142A (ja) | 2018-07-25 | 2022-12-28 | 新規なヒアルロン酸加水分解酵素変異体およびそれを含む薬学組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022211105A Division JP2023052142A (ja) | 2018-07-25 | 2022-12-28 | 新規なヒアルロン酸加水分解酵素変異体およびそれを含む薬学組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025004002A JP2025004002A (ja) | 2025-01-14 |
| JP2025004002A5 true JP2025004002A5 (enExample) | 2025-03-19 |
Family
ID=69182377
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500863A Active JP7204729B2 (ja) | 2018-07-25 | 2019-07-25 | 新規なヒアルロン酸加水分解酵素変異体およびそれを含む薬学組成物 |
| JP2022211105A Pending JP2023052142A (ja) | 2018-07-25 | 2022-12-28 | 新規なヒアルロン酸加水分解酵素変異体およびそれを含む薬学組成物 |
| JP2024159834A Pending JP2025004002A (ja) | 2018-07-25 | 2024-09-17 | 新規なヒアルロン酸加水分解酵素変異体およびそれを含む薬学組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500863A Active JP7204729B2 (ja) | 2018-07-25 | 2019-07-25 | 新規なヒアルロン酸加水分解酵素変異体およびそれを含む薬学組成物 |
| JP2022211105A Pending JP2023052142A (ja) | 2018-07-25 | 2022-12-28 | 新規なヒアルロン酸加水分解酵素変異体およびそれを含む薬学組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12371683B2 (enExample) |
| EP (1) | EP3636752B1 (enExample) |
| JP (3) | JP7204729B2 (enExample) |
| KR (3) | KR102151388B1 (enExample) |
| CN (5) | CN118853631A (enExample) |
| AU (3) | AU2019311658B2 (enExample) |
| BR (1) | BR112020019041A2 (enExample) |
| CA (1) | CA3093885A1 (enExample) |
| MX (1) | MX2020009824A (enExample) |
| WO (1) | WO2020022791A1 (enExample) |
Families Citing this family (54)
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| EP2330213A1 (en) | 2003-03-05 | 2011-06-08 | Halozyme, Inc. | Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
| SG11201403714TA (en) | 2011-12-30 | 2014-07-30 | Halozyme Inc | Ph20 polypeptide variants, formulations and uses thereof |
| MX2020009824A (es) | 2018-07-25 | 2021-01-15 | Alteogen Inc | Nuevas variantes de hialuronidasa y composicion farmaceutica que comprende la misma. |
| MX2021004356A (es) | 2018-10-18 | 2021-05-31 | Merck Sharp & Dohme Llc | Formulaciones de anticuerpos anti-rsv y metodos de uso de las mismas. |
| MA54089A (fr) | 2018-10-31 | 2022-02-09 | Merck Sharp & Dohme | Anticorps anti-pd-1 humain et procédés d'utilisation associés |
| JP7503056B6 (ja) | 2018-11-07 | 2024-07-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体および抗ｐｄ－１抗体の共－製剤 |
| CN112203642B (zh) * | 2019-03-25 | 2025-03-07 | 阿特根公司 | 用于皮下注射的包含人透明质酸酶ph20变体和药物的药物组合物 |
| TW202615652A (zh) | 2020-01-23 | 2026-04-16 | 南韓商阿特根公司 | 新穎的具有改善的穩定性的玻尿酸酶變異體及含有其的醫藥組合物 |
| CA3181682A1 (en) | 2020-07-17 | 2022-01-20 | Anil Kapur | Subcutaneous telomerase inhibitor compositions and methods for using same |
| WO2022031093A1 (ko) | 2020-08-07 | 2022-02-10 | (주)알테오젠 | 재조합 히알루로니다제의 생산 방법 |
| US20230365692A1 (en) * | 2020-09-24 | 2023-11-16 | Merck Sharp & Dohme Llc | Stable formulations of programmed death receptor 1 (pd-1) antibodies and hyaluronidase variants and fragments thereof and methods of use thereof |
| AU2021416156A1 (en) | 2020-12-28 | 2023-06-22 | Bristol-Myers Squibb Company | Methods of treating tumors |
| PT4267105T (pt) | 2020-12-28 | 2025-04-30 | Bristol Myers Squibb Co | Composições de anticorpos e métodos de utilização das mesmas |
| TW202305009A (zh) | 2021-04-08 | 2023-02-01 | 美商默沙東有限責任公司 | 以皮下投予抗pd1抗體治療癌症之方法 |
| CN115671267A (zh) | 2021-07-23 | 2023-02-03 | 上海宝济药业有限公司 | 一种皮下抗生素药物组合物 |
| WO2023012515A2 (en) | 2021-08-02 | 2023-02-09 | argenx BV | Subcutaneous unit dosage forms |
| WO2023042096A1 (en) | 2021-09-14 | 2023-03-23 | Takeda Pharmaceutical Company Limited | Facilitated delivery of concentrated antibody formulations using hyaluronidase |
| CA3236277A1 (en) * | 2021-10-29 | 2023-05-04 | Soon Jae Park | Pharmaceutical composition comprising human hyaluronidase ph20 and drug |
| US20250099612A1 (en) | 2022-03-01 | 2025-03-27 | Exuma Biotech Corp. | Viral particles with membrane-bound hyaluronidase |
| CN114573715A (zh) * | 2022-03-14 | 2022-06-03 | 江苏雅酶医药科技有限公司 | 一种重组长效人透明质酸酶及其生产方法和应用 |
| KR20230150203A (ko) | 2022-04-20 | 2023-10-30 | 주식회사 알토스바이오로직스 | 오크렐리주맙(Ocrelizumab)을 포함하는 약학적 조성물과 그의 용도 |
| AU2023281061A1 (en) | 2022-06-02 | 2024-12-05 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| KR102774438B1 (ko) * | 2022-06-08 | 2025-02-27 | (주)한국비엠아이 | 히알루로니다제 폴리펩티드 및 이의 용도 |
| WO2023249408A1 (ko) * | 2022-06-22 | 2023-12-28 | (주)알테오젠 | N-말단 및/또는 c-말단이 절단된 가용성 ph20 폴리펩티드 및 이의 용도 |
| KR102621518B1 (ko) * | 2022-06-29 | 2024-01-10 | 주식회사 오디스젠 | 중성 pH에서 활성을 나타내는 히알루로니다제 Hyal1변이체 |
| KR102976805B1 (ko) * | 2023-06-26 | 2026-06-15 | 주식회사 오디스젠 | 신규 인간 히알루로니다제 Hyal1 변이체 |
| JP7894954B2 (ja) * | 2022-06-29 | 2026-07-24 | オディスジェン インコーポレイテッド | 中性ｐＨで活性を示すヒアルロニダーゼＨＹＡＬ１変異体 |
| CN119894932A (zh) * | 2022-07-28 | 2025-04-25 | 默沙东有限责任公司 | 程序性死亡受体1（PD-1）抗体和rHuPH20或其变体或片段的药物组合物 |
| WO2024025986A1 (en) * | 2022-07-28 | 2024-02-01 | Merck Sharp & Dohme Llc | Pharmaceutical compositions of programmed death receptor 1 (pd-1) antibodies and ph20 variants or fragments thereof |
| KR20240038901A (ko) * | 2022-09-16 | 2024-03-26 | (주)피앤피바이오팜 | 신규한 히알루로니다제 ph-20 변이체 및 그 용도 |
| KR20250134732A (ko) | 2022-12-22 | 2025-09-11 | 할로자임, 아이엔씨 | 대용량 투여를 위한 히알루로니다아제 효소 제형 |
| WO2024196173A1 (ko) * | 2023-03-23 | 2024-09-26 | (주)알테오젠 | 신규 히알루론산 가수분해 효소 변이체 및 이를 포함하는 약제학적 조성물 |
| KR20250086876A (ko) * | 2023-12-06 | 2025-06-16 | (주)한국비엠아이 | 히알루로니다제 폴리펩티드와 약물을 포함하는 피하투여용 조성물 |
| KR102896967B1 (ko) * | 2023-12-21 | 2025-12-09 | 주식회사 오디스젠 | 개선된 특성을 갖는 히알루로니다제 Hyal2 변이체 |
| WO2025136032A1 (ko) * | 2023-12-21 | 2025-06-26 | 주식회사 오디스젠 | 개선된 특성을 갖는 히알루로니다제 hyal2 변이체 |
| KR102875495B1 (ko) * | 2023-12-28 | 2025-10-27 | 주식회사 오디스젠 | 히알루로니다제 Hyal1 변이체 |
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| WO2025188901A1 (en) | 2024-03-05 | 2025-09-12 | Halozyme, Inc. | Combination therapy with antibody-drug conjugates and hyaluronidases |
| TW202617771A (zh) | 2024-06-21 | 2026-05-01 | 美商艾普吉醫療股份有限公司 | 結合ｉｌ－１３之抗體及結合ｏｘ４０ｌ之抗體 |
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| MX2020009824A (es) | 2018-07-25 | 2021-01-15 | Alteogen Inc | Nuevas variantes de hialuronidasa y composicion farmaceutica que comprende la misma. |
| AU2020225631A1 (en) | 2019-02-22 | 2021-09-16 | Memorial Sloan Kettering Cancer Center | CD33 antibodies and methods of using the same to treat cancer |
| CN112203642B (zh) | 2019-03-25 | 2025-03-07 | 阿特根公司 | 用于皮下注射的包含人透明质酸酶ph20变体和药物的药物组合物 |
| JP2020197994A (ja) | 2019-06-04 | 2020-12-10 | 東芝テック株式会社 | 情報処理装置及びその制御プログラム |
| TW202615652A (zh) | 2020-01-23 | 2026-04-16 | 南韓商阿特根公司 | 新穎的具有改善的穩定性的玻尿酸酶變異體及含有其的醫藥組合物 |
| WO2022031093A1 (ko) | 2020-08-07 | 2022-02-10 | (주)알테오젠 | 재조합 히알루로니다제의 생산 방법 |
| US20230365692A1 (en) | 2020-09-24 | 2023-11-16 | Merck Sharp & Dohme Llc | Stable formulations of programmed death receptor 1 (pd-1) antibodies and hyaluronidase variants and fragments thereof and methods of use thereof |
| CA3236277A1 (en) | 2021-10-29 | 2023-05-04 | Soon Jae Park | Pharmaceutical composition comprising human hyaluronidase ph20 and drug |
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2019
- 2019-07-25 MX MX2020009824A patent/MX2020009824A/es unknown
- 2019-07-25 CN CN202411131157.8A patent/CN118853631A/zh active Pending
- 2019-07-25 AU AU2019311658A patent/AU2019311658B2/en active Active
- 2019-07-25 KR KR1020207002955A patent/KR102151388B1/ko active Active
- 2019-07-25 CA CA3093885A patent/CA3093885A1/en active Pending
- 2019-07-25 US US16/628,258 patent/US12371683B2/en active Active
- 2019-07-25 WO PCT/KR2019/009215 patent/WO2020022791A1/ko not_active Ceased
- 2019-07-25 CN CN201980023392.4A patent/CN111971387A/zh active Pending
- 2019-07-25 KR KR1020207024813A patent/KR20210023798A/ko active Pending
- 2019-07-25 BR BR112020019041-1A patent/BR112020019041A2/pt unknown
- 2019-07-25 CN CN202411133487.0A patent/CN118755703A/zh active Pending
- 2019-07-25 KR KR1020257002900A patent/KR20250021616A/ko active Pending
- 2019-07-25 CN CN202411127100.0A patent/CN118792283A/zh active Pending
- 2019-07-25 EP EP19827585.1A patent/EP3636752B1/en active Active
- 2019-07-25 CN CN202411131388.9A patent/CN118773171B/zh active Active
- 2019-07-25 JP JP2020500863A patent/JP7204729B2/ja active Active
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2022
- 2022-12-28 JP JP2022211105A patent/JP2023052142A/ja active Pending
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2023
- 2023-01-20 AU AU2023200324A patent/AU2023200324B9/en active Active
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2024
- 2024-09-17 JP JP2024159834A patent/JP2025004002A/ja active Pending
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2025
- 2025-06-06 US US19/231,008 patent/US20250368976A1/en active Pending
- 2025-12-03 AU AU2025275191A patent/AU2025275191A1/en active Pending
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