JP2001513982A5 - - Google Patents

Info

Publication number

JP2001513982A5

JP2001513982A5 JP2000507690A JP2000507690A JP2001513982A5 JP 2001513982 A5 JP2001513982 A5 JP 2001513982A5 JP 2000507690 A JP2000507690 A JP 2000507690A JP 2000507690 A JP2000507690 A JP 2000507690A JP 2001513982 A5 JP2001513982 A5 JP 2001513982A5

Authority

JP

Japan

Prior art keywords

polypeptide

nucleotide sequence

amino acid

seq

sequence

Prior art date

1998-08-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 239000002773 nucleotide Substances 0.000 description 38
• 125000003729 nucleotide group Chemical group 0.000 description 38
• 229920001184 polypeptide Polymers 0.000 description 38
• 102000004196 processed proteins & peptides Human genes 0.000 description 38
• 108090000765 processed proteins & peptides Proteins 0.000 description 38
• 102000039446 nucleic acids Human genes 0.000 description 22
• 108020004707 nucleic acids Proteins 0.000 description 22
• 150000007523 nucleic acids Chemical class 0.000 description 22
• 125000003275 alpha amino acid group Chemical group 0.000 description 18
• 239000002157 polynucleotide Substances 0.000 description 16
• 108091033319 polynucleotide Proteins 0.000 description 15
• 102000040430 polynucleotide Human genes 0.000 description 15
• 239000002299 complementary DNA Substances 0.000 description 14
• 210000004027 cell Anatomy 0.000 description 11
• 238000000034 method Methods 0.000 description 11
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 9
• 125000000539 amino acid group Chemical group 0.000 description 7
• 239000002253 acid Substances 0.000 description 6
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 4
• 150000001413 amino acids Chemical group 0.000 description 4
• 230000014509 gene expression Effects 0.000 description 3
• 108090000623 proteins and genes Proteins 0.000 description 3
• -1 Amino Chemical group 0.000 description 2
• 241000588724 Escherichia coli Species 0.000 description 2
• 230000000295 complement effect Effects 0.000 description 2
• 150000001875 compounds Chemical class 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 238000009396 hybridization Methods 0.000 description 2
• 229930182817 methionine Natural products 0.000 description 2
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
• 102000004169 proteins and genes Human genes 0.000 description 2
• 230000001105 regulatory effect Effects 0.000 description 2
• 241000238631 Hexapoda Species 0.000 description 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
• 108091028043 Nucleic acid sequence Proteins 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 210000004102 animal cell Anatomy 0.000 description 1
• 210000004899 c-terminal region Anatomy 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 210000003527 eukaryotic cell Anatomy 0.000 description 1
• 230000002538 fungal effect Effects 0.000 description 1
• 230000004927 fusion Effects 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 210000004962 mammalian cell Anatomy 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• 210000001236 prokaryotic cell Anatomy 0.000 description 1