JP2010522568A5 - - Google Patents
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- Publication number
- JP2010522568A5 JP2010522568A5 JP2010501233A JP2010501233A JP2010522568A5 JP 2010522568 A5 JP2010522568 A5 JP 2010522568A5 JP 2010501233 A JP2010501233 A JP 2010501233A JP 2010501233 A JP2010501233 A JP 2010501233A JP 2010522568 A5 JP2010522568 A5 JP 2010522568A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid residues
- seq
- peptide
- mutated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000539 amino acid group Chemical group 0.000 claims 80
- 108090000765 processed proteins & peptides Proteins 0.000 claims 45
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 16
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 16
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 16
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 16
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 16
- 239000004473 Threonine Substances 0.000 claims 16
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 239000003446 ligand Substances 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 3
- 108091008146 restriction endonucleases Proteins 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 2
- 230000004807 localization Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- -1 spacer amino acid Chemical class 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 230000030570 cellular localization Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90823107P | 2007-03-27 | 2007-03-27 | |
| US60/908,231 | 2007-03-27 | ||
| PCT/US2008/058531 WO2008119058A2 (en) | 2007-03-27 | 2008-03-27 | Mek ligands and polynucleotides encoding mek ligands |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010522568A JP2010522568A (ja) | 2010-07-08 |
| JP2010522568A5 true JP2010522568A5 (enExample) | 2011-10-06 |
| JP5611814B2 JP5611814B2 (ja) | 2014-10-22 |
Family
ID=39789285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501233A Expired - Fee Related JP5611814B2 (ja) | 2007-03-27 | 2008-03-27 | Ｍｅｋリガンドおよびｍｅｋリガンドをコードするポリヌクレオチド |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8575304B2 (enExample) |
| EP (2) | EP2126064B1 (enExample) |
| JP (1) | JP5611814B2 (enExample) |
| KR (1) | KR101557167B1 (enExample) |
| CN (1) | CN101679956A (enExample) |
| AU (1) | AU2008230711B9 (enExample) |
| CA (1) | CA2680837C (enExample) |
| DK (1) | DK2126064T3 (enExample) |
| ES (1) | ES2390156T3 (enExample) |
| IL (1) | IL201192A (enExample) |
| WO (1) | WO2008119058A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8153598B2 (en) | 2005-10-19 | 2012-04-10 | Intrexon Corporation | PKD ligands and polynucleotides encoding PKD ligands |
| US7943732B2 (en) | 2006-06-05 | 2011-05-17 | Intrexon Corporation | AKT ligands and polynucleotides encoding AKT ligands |
| US8993263B2 (en) | 2006-08-07 | 2015-03-31 | Intrexon Corporation | PKA ligands and polynucleotides encoding PKA ligands |
| US8999666B2 (en) | 2006-08-09 | 2015-04-07 | Intrexon Corporation | PKC ligands and polynucleotides encoding PKC ligands |
| US8729225B2 (en) | 2006-11-13 | 2014-05-20 | Intrexon Corporation | Glycogen synthase kinase heteropolyligand polypeptide |
| US8283445B2 (en) | 2006-11-13 | 2012-10-09 | Intrexon Corporation | Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide |
| US7705122B2 (en) | 2006-12-04 | 2010-04-27 | Intrexon Corporation | mTOR ligands and polynucleotides encoding mTOR ligands |
| US8575304B2 (en) | 2007-03-27 | 2013-11-05 | Intrexon Corporation | MEK ligands and polynucleotides encoding MEK ligands |
| CA2685592C (en) | 2007-05-02 | 2018-08-07 | Intrexon Corporation | Pp1 ligands |
| US8431363B2 (en) * | 2008-01-09 | 2013-04-30 | Intrexon Corporation | Polynucleotides encoding therapeutic inhibitors of PAI-1 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904395D0 (en) | 1999-02-25 | 1999-04-21 | Fluorescience Ltd | Protein assay |
| AUPR230500A0 (en) * | 2000-12-22 | 2001-01-25 | University Of Newcastle Research Associates Limited, The | A method of modulating map kinase mediated cellular activity and agents useful in same |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| AU2002348791A1 (en) * | 2001-12-21 | 2003-07-09 | Warner-Lambert Company Llc | Modified mek1 and mek2, crystal of a peptide: ligand: cofactor complex containing such modified mek1 or mek2, and methods of use thereof |
| AU2003245627A1 (en) * | 2002-06-21 | 2004-01-06 | Incyte Corporation | Kinases and phosphatases |
| US7785871B2 (en) | 2002-10-09 | 2010-08-31 | Intrexon Corporation | DNA cloning vector plasmids and methods for their use |
| US20080050808A1 (en) | 2002-10-09 | 2008-02-28 | Reed Thomas D | DNA modular cloning vector plasmids and methods for their use |
| US7071295B2 (en) | 2002-12-02 | 2006-07-04 | Intrexon Corporation | Signal for targeting molecules to the sarco(endo)plasmic reticulum |
| US20080220497A1 (en) | 2003-12-24 | 2008-09-11 | Flynn Daniel L | Modulation of protein functionalities |
| WO2005113812A2 (en) * | 2004-04-23 | 2005-12-01 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| CN1981047B (zh) | 2004-05-18 | 2013-08-21 | 英特拉克森公司 | Dna克隆载体质粒的动态载体装配方法 |
| WO2006039367A2 (en) * | 2004-10-01 | 2006-04-13 | Mount Sinai School Of Medicine Of New York University | Resonance energy transfer system and method |
| WO2007048103A2 (en) | 2006-10-18 | 2007-04-26 | Intrexon Corporation | Pkd ligands and polynucleotides encoding pkd ligands |
| US8153598B2 (en) | 2005-10-19 | 2012-04-10 | Intrexon Corporation | PKD ligands and polynucleotides encoding PKD ligands |
| US7943732B2 (en) | 2006-06-05 | 2011-05-17 | Intrexon Corporation | AKT ligands and polynucleotides encoding AKT ligands |
| US8993263B2 (en) | 2006-08-07 | 2015-03-31 | Intrexon Corporation | PKA ligands and polynucleotides encoding PKA ligands |
| US8999666B2 (en) | 2006-08-09 | 2015-04-07 | Intrexon Corporation | PKC ligands and polynucleotides encoding PKC ligands |
| US8283445B2 (en) | 2006-11-13 | 2012-10-09 | Intrexon Corporation | Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide |
| US8729225B2 (en) | 2006-11-13 | 2014-05-20 | Intrexon Corporation | Glycogen synthase kinase heteropolyligand polypeptide |
| US7705122B2 (en) | 2006-12-04 | 2010-04-27 | Intrexon Corporation | mTOR ligands and polynucleotides encoding mTOR ligands |
| US7927987B2 (en) | 2007-03-27 | 2011-04-19 | Texas Instruments Incorporated | Method of reducing channeling of ion implants using a sacrificial scattering layer |
| US8575304B2 (en) | 2007-03-27 | 2013-11-05 | Intrexon Corporation | MEK ligands and polynucleotides encoding MEK ligands |
-
2008
- 2008-03-27 US US12/532,912 patent/US8575304B2/en not_active Expired - Fee Related
- 2008-03-27 ES ES08744516T patent/ES2390156T3/es active Active
- 2008-03-27 EP EP08744516A patent/EP2126064B1/en not_active Not-in-force
- 2008-03-27 JP JP2010501233A patent/JP5611814B2/ja not_active Expired - Fee Related
- 2008-03-27 WO PCT/US2008/058531 patent/WO2008119058A2/en not_active Ceased
- 2008-03-27 AU AU2008230711A patent/AU2008230711B9/en not_active Ceased
- 2008-03-27 DK DK08744516.9T patent/DK2126064T3/da active
- 2008-03-27 CA CA2680837A patent/CA2680837C/en not_active Expired - Fee Related
- 2008-03-27 EP EP12170618.8A patent/EP2537924B1/en not_active Ceased
- 2008-03-27 CN CN200880017643A patent/CN101679956A/zh active Pending
- 2008-03-27 KR KR1020097022413A patent/KR101557167B1/ko not_active Expired - Fee Related
-
2009
- 2009-09-24 IL IL201192A patent/IL201192A/en active IP Right Grant
-
2013
- 2013-10-04 US US14/046,454 patent/US9006390B2/en not_active Expired - Fee Related
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