KR101557167B1 - Ｍｅｋ 리간드 및 이를 인코딩하는 폴리뉴클레오티드 - Google Patents

Ｍｅｋ 리간드 및 이를 인코딩하는 폴리뉴클레오티드 Download PDF

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KR101557167B1
KR101557167B1 KR1020097022413A KR20097022413A KR101557167B1 KR 101557167 B1 KR101557167 B1 KR 101557167B1 KR 1020097022413 A KR1020097022413 A KR 1020097022413A KR 20097022413 A KR20097022413 A KR 20097022413A KR 101557167 B1 KR101557167 B1 KR 101557167B1
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amino acid
seq
leu
ligand
ala
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KR20100015944A (ko
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데이비드 바친스키
조나단 칼슨
에이미 엣젤
토마스 리드
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인트렉손 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11024—Mitogen-activated protein kinase (2.7.11.24), i.e. MAPK or MAPK2 or c-Jun N-terminal kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/12—Dual-specificity kinases (2.7.12)
    • C12Y207/12002—Mitogen-activated protein kinase kinase (2.7.12.2), i.e. MAPKK or MEK1 or MEK2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020097022413A 2007-03-27 2008-03-27 Ｍｅｋ 리간드 및 이를 인코딩하는 폴리뉴클레오티드 Expired - Fee Related KR101557167B1 (ko)

Applications Claiming Priority (2)

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US90823107P 2007-03-27 2007-03-27
US60/908,231 2007-03-27

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KR20100015944A KR20100015944A (ko) 2010-02-12
KR101557167B1 true KR101557167B1 (ko) 2015-10-02

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KR1020097022413A Expired - Fee Related KR101557167B1 (ko) 2007-03-27 2008-03-27 Ｍｅｋ 리간드 및 이를 인코딩하는 폴리뉴클레오티드

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US (2) US8575304B2 (enExample)
EP (2) EP2126064B1 (enExample)
JP (1) JP5611814B2 (enExample)
KR (1) KR101557167B1 (enExample)
CN (1) CN101679956A (enExample)
AU (1) AU2008230711B9 (enExample)
CA (1) CA2680837C (enExample)
DK (1) DK2126064T3 (enExample)
ES (1) ES2390156T3 (enExample)
IL (1) IL201192A (enExample)
WO (1) WO2008119058A2 (enExample)

Families Citing this family (10)

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US8153598B2 (en) 2005-10-19 2012-04-10 Intrexon Corporation PKD ligands and polynucleotides encoding PKD ligands
US7943732B2 (en) 2006-06-05 2011-05-17 Intrexon Corporation AKT ligands and polynucleotides encoding AKT ligands
US8993263B2 (en) 2006-08-07 2015-03-31 Intrexon Corporation PKA ligands and polynucleotides encoding PKA ligands
US8999666B2 (en) 2006-08-09 2015-04-07 Intrexon Corporation PKC ligands and polynucleotides encoding PKC ligands
US8729225B2 (en) 2006-11-13 2014-05-20 Intrexon Corporation Glycogen synthase kinase heteropolyligand polypeptide
US8283445B2 (en) 2006-11-13 2012-10-09 Intrexon Corporation Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide
US7705122B2 (en) 2006-12-04 2010-04-27 Intrexon Corporation mTOR ligands and polynucleotides encoding mTOR ligands
US8575304B2 (en) 2007-03-27 2013-11-05 Intrexon Corporation MEK ligands and polynucleotides encoding MEK ligands
CA2685592C (en) 2007-05-02 2018-08-07 Intrexon Corporation Pp1 ligands
US8431363B2 (en) * 2008-01-09 2013-04-30 Intrexon Corporation Polynucleotides encoding therapeutic inhibitors of PAI-1

Citations (2)

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WO2002051993A1 (en) 2000-12-22 2002-07-04 The University Of Newcastle Research Associates Limited MAP kinase integrin-binding domain
US20050089932A1 (en) 2001-04-26 2005-04-28 Avidia Research Institute Novel proteins with targeted binding

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GB9904395D0 (en) 1999-02-25 1999-04-21 Fluorescience Ltd Protein assay
AU2002348791A1 (en) * 2001-12-21 2003-07-09 Warner-Lambert Company Llc Modified mek1 and mek2, crystal of a peptide: ligand: cofactor complex containing such modified mek1 or mek2, and methods of use thereof
AU2003245627A1 (en) * 2002-06-21 2004-01-06 Incyte Corporation Kinases and phosphatases
US7785871B2 (en) 2002-10-09 2010-08-31 Intrexon Corporation DNA cloning vector plasmids and methods for their use
US20080050808A1 (en) 2002-10-09 2008-02-28 Reed Thomas D DNA modular cloning vector plasmids and methods for their use
US7071295B2 (en) 2002-12-02 2006-07-04 Intrexon Corporation Signal for targeting molecules to the sarco(endo)plasmic reticulum
US20080220497A1 (en) 2003-12-24 2008-09-11 Flynn Daniel L Modulation of protein functionalities
WO2005113812A2 (en) * 2004-04-23 2005-12-01 Invitrogen Corporation Collections of matched biological reagents and methods for identifying matched reagents
CN1981047B (zh) 2004-05-18 2013-08-21 英特拉克森公司 Dna克隆载体质粒的动态载体装配方法
WO2006039367A2 (en) * 2004-10-01 2006-04-13 Mount Sinai School Of Medicine Of New York University Resonance energy transfer system and method
WO2007048103A2 (en) 2006-10-18 2007-04-26 Intrexon Corporation Pkd ligands and polynucleotides encoding pkd ligands
US8153598B2 (en) 2005-10-19 2012-04-10 Intrexon Corporation PKD ligands and polynucleotides encoding PKD ligands
US7943732B2 (en) 2006-06-05 2011-05-17 Intrexon Corporation AKT ligands and polynucleotides encoding AKT ligands
US8993263B2 (en) 2006-08-07 2015-03-31 Intrexon Corporation PKA ligands and polynucleotides encoding PKA ligands
US8999666B2 (en) 2006-08-09 2015-04-07 Intrexon Corporation PKC ligands and polynucleotides encoding PKC ligands
US8283445B2 (en) 2006-11-13 2012-10-09 Intrexon Corporation Extracellular-signal-regulated-kinase (ERK) heteropolyligand polypeptide
US8729225B2 (en) 2006-11-13 2014-05-20 Intrexon Corporation Glycogen synthase kinase heteropolyligand polypeptide
US7705122B2 (en) 2006-12-04 2010-04-27 Intrexon Corporation mTOR ligands and polynucleotides encoding mTOR ligands
US7927987B2 (en) 2007-03-27 2011-04-19 Texas Instruments Incorporated Method of reducing channeling of ion implants using a sacrificial scattering layer
US8575304B2 (en) 2007-03-27 2013-11-05 Intrexon Corporation MEK ligands and polynucleotides encoding MEK ligands

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051993A1 (en) 2000-12-22 2002-07-04 The University Of Newcastle Research Associates Limited MAP kinase integrin-binding domain
US20050089932A1 (en) 2001-04-26 2005-04-28 Avidia Research Institute Novel proteins with targeted binding

Non-Patent Citations (2)

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Title
Current Biology. 1998, Vol. 8, pages 1141-1150.
J Biol chem, 1998, Vol. 273, No. 48, pp32182-32186

Also Published As

Publication number Publication date
DK2126064T3 (da) 2012-09-10
IL201192A (en) 2014-11-30
HK1138876A1 (en) 2010-09-03
AU2008230711B2 (en) 2014-03-27
WO2008119058A9 (en) 2008-12-24
EP2537924B1 (en) 2015-03-18
EP2537924A2 (en) 2012-12-26
US9006390B2 (en) 2015-04-14
EP2537924A3 (en) 2013-04-10
WO2008119058A2 (en) 2008-10-02
EP2126064A2 (en) 2009-12-02
JP5611814B2 (ja) 2014-10-22
AU2008230711A1 (en) 2008-10-02
US20140073028A1 (en) 2014-03-13
CA2680837C (en) 2017-06-06
IL201192A0 (en) 2011-08-01
CA2680837A1 (en) 2008-10-02
KR20100015944A (ko) 2010-02-12
CN101679956A (zh) 2010-03-24
WO2008119058A3 (en) 2009-02-12
EP2126064A4 (en) 2010-06-23
US8575304B2 (en) 2013-11-05
EP2126064B1 (en) 2012-06-06
AU2008230711B9 (en) 2014-08-21
JP2010522568A (ja) 2010-07-08
ES2390156T3 (es) 2012-11-07
US20100279378A1 (en) 2010-11-04

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US8993531B2 (en) PKD ligands and polynucleotides encoding PKD ligands
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US9493525B2 (en) AKT ligands and polynucleotides encoding AKT ligands
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