|
HUE035567T2
(en)
|
2003-09-30 |
2018-05-28 |
Univ Pennsylvania |
Adeno-associated virus (AAV) clusters, sequences, vectors and applications containing them
|
|
US9217155B2
(en)
|
2008-05-28 |
2015-12-22 |
University Of Massachusetts |
Isolation of novel AAV'S and uses thereof
|
|
US8734809B2
(en)
|
2009-05-28 |
2014-05-27 |
University Of Massachusetts |
AAV's and uses thereof
|
|
CA2833912C
(en)
|
2010-04-23 |
2021-09-21 |
University Of Massachusetts |
Aav-based treatment of cholesterol-related disorders
|
|
JP5963743B2
(ja)
|
2010-04-23 |
2016-08-03 |
ユニバーシティ オブ マサチューセッツ |
Cnsターゲティングaavベクターおよびその使用方法
|
|
US9409953B2
(en)
|
2011-02-10 |
2016-08-09 |
The University Of North Carolina At Chapel Hill |
Viral vectors with modified transduction profiles and methods of making and using the same
|
|
SG10201601110VA
(en)
|
2011-02-17 |
2016-03-30 |
Univ Pennsylvania |
Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer
|
|
US9226976B2
(en)
|
2011-04-21 |
2016-01-05 |
University Of Massachusetts |
RAAV-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
|
|
WO2013170078A1
(en)
*
|
2012-05-09 |
2013-11-14 |
Oregon Health & Science University |
Adeno associated virus plasmids and vectors
|
|
EP2749569A1
(en)
|
2012-12-28 |
2014-07-02 |
Annibale Alessandro Puca |
Variant of BPIFB4 protein
|
|
US20140219964A1
(en)
*
|
2013-02-07 |
2014-08-07 |
Children's Medical Center Corporation |
Methods for inducing cardiomyocyte proliferation
|
|
AU2014244167A1
(en)
*
|
2013-03-13 |
2015-10-08 |
The Children's Hospital Of Philadelphia |
Adeno-associated virus vectors and methods of use thereof
|
|
WO2014144229A1
(en)
*
|
2013-03-15 |
2014-09-18 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for dual glycan binding aav vectors
|
|
MX386059B
(es)
|
2013-03-15 |
2025-03-18 |
Univ Pennsylvania |
COMPOSICIONES Y SUS usos EN EL TRATAMIENTO DE LA MUCOPOLISACARIDOSIS TIPO I.
|
|
CA2943185C
(en)
|
2014-03-21 |
2025-09-16 |
Genzyme Corp |
Gene therapy for retinitis pigmentosa
|
|
WO2015164757A1
(en)
*
|
2014-04-25 |
2015-10-29 |
Oregon Health & Science University |
Methods of viral neutralizing antibody epitope mapping
|
|
US10689653B2
(en)
|
2014-06-03 |
2020-06-23 |
University Of Massachusetts |
Compositions and methods for modulating dysferlin expression
|
|
US10577627B2
(en)
|
2014-06-09 |
2020-03-03 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
WO2016044478A1
(en)
|
2014-09-16 |
2016-03-24 |
Genzyme Corporation |
Adeno-associated viral vectors for treating myocilin (myoc) glaucoma
|
|
EP4012035B1
(en)
|
2014-09-16 |
2024-11-06 |
Genzyme Corporation |
Adeno-associated viral vectors for treating myocilin (myoc) glaucoma
|
|
WO2016054554A1
(en)
|
2014-10-03 |
2016-04-07 |
University Of Massachusetts |
Heterologous targeting peptide grafted aavs
|
|
JP6842410B2
(ja)
|
2014-10-03 |
2021-03-17 |
ユニバーシティ オブ マサチューセッツ |
新規の高効率ライブラリーにより同定されるaavベクター
|
|
WO2016065001A1
(en)
|
2014-10-21 |
2016-04-28 |
University Of Massachusetts |
Recombinant aav variants and uses thereof
|
|
WO2016073693A2
(en)
|
2014-11-05 |
2016-05-12 |
Voyager Therapeutics, Inc. |
Aadc polynucleotides for the treatment of parkinson's disease
|
|
CA2975583A1
(en)
|
2014-11-14 |
2016-05-19 |
Voyager Therapeutics, Inc. |
Modulatory polynucleotides
|
|
CN114717264A
(zh)
|
2014-11-14 |
2022-07-08 |
沃雅戈治疗公司 |
治疗肌萎缩性侧索硬化(als)的组合物和方法
|
|
US11697825B2
(en)
|
2014-12-12 |
2023-07-11 |
Voyager Therapeutics, Inc. |
Compositions and methods for the production of scAAV
|
|
EA201791630A1
(ru)
|
2015-01-20 |
2018-04-30 |
Джензим Корпорейшн |
Аналитическое ультрацентрифугирование для определения характеристик рекомбинантных вирусных частиц
|
|
HK1247641A1
(zh)
|
2015-02-10 |
2018-09-28 |
Genzyme Corporation |
变体RNAi
|
|
LT3256594T
(lt)
|
2015-02-10 |
2022-02-10 |
Genzyme Corporation |
Patobulintas virusinių dalelių tiekimas į dryžuotąjį kūną ir smegenų žievę
|
|
EP3256170B1
(en)
|
2015-02-13 |
2020-09-23 |
University of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
TWI707951B
(zh)
|
2015-04-08 |
2020-10-21 |
美商健臻公司 |
過大腺相關載體之製造
|
|
WO2016172008A1
(en)
|
2015-04-24 |
2016-10-27 |
University Of Massachusetts |
Modified aav constructions and uses thereof
|
|
WO2016186772A2
(en)
|
2015-05-16 |
2016-11-24 |
Genzyme Corporation |
Gene editing of deep intronic mutations
|
|
CA2988471A1
(en)
*
|
2015-07-28 |
2017-02-02 |
University Of Massachusetts |
Transgenic expression of dnase i in vivo delivered by an adeno-associated virus vector
|
|
EP3364996B1
(en)
|
2015-10-22 |
2021-08-25 |
University of Massachusetts |
Prostate-targeting adeno-associated virus serotype vectors
|
|
DK3364997T5
(da)
|
2015-10-22 |
2024-09-30 |
Univ Massachusetts |
Aspartoacylase genterapi til behandling af canavans sygdom
|
|
CA3006569A1
(en)
|
2015-12-02 |
2017-06-08 |
Voyager Therapeutics, Inc. |
Assays for the detection of aav neutralizing antibodies
|
|
EP3387118B1
(en)
|
2015-12-11 |
2022-04-06 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aavrh10
|
|
EP3387138B1
(en)
|
2015-12-11 |
2022-01-26 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aav9
|
|
WO2017100674A1
(en)
|
2015-12-11 |
2017-06-15 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aav1
|
|
EP3387117B1
(en)
|
2015-12-11 |
2022-11-23 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aav8
|
|
IL259964B
(en)
|
2015-12-15 |
2022-09-01 |
Genzyme Corp |
Adenovirus-associated vectors for the treatment of mucolipodosis type ii
|
|
EP3411059A4
(en)
|
2016-02-02 |
2019-10-16 |
University Of Massachusetts |
METHOD FOR INCREASING THE EFFECTIVENESS OF THE SYSTEMIC DELIVERY OF AVV GENES TO THE CENTRAL NERVOUS SYSTEM
|
|
IL260959B2
(en)
|
2016-02-03 |
2024-09-01 |
Univ Pennsylvania |
Gene therapy for treating mucopolysaccharidosis type i
|
|
US11060088B2
(en)
|
2016-02-12 |
2021-07-13 |
University Of Massachusetts |
Anti-angiogenic miRNA therapeutics for inhibiting corneal neovascularization
|
|
EP3440210A4
(en)
|
2016-04-05 |
2019-11-27 |
University of Massachusetts |
COMPOSITIONS AND METHOD FOR SELECTIVELY INHIBITING THE EXPRESSION OF GRAINYHEAD LIKE PROTEIN
|
|
SG11201808176TA
(en)
|
2016-04-15 |
2018-10-30 |
The Trustees Of The Univ Of Pennsyvania |
Gene therapy for treating mucopolysaccharidosis type ii
|
|
US11413356B2
(en)
|
2016-04-15 |
2022-08-16 |
University Of Massachusetts |
Methods and compositions for treating metabolic imbalance
|
|
US11299751B2
(en)
|
2016-04-29 |
2022-04-12 |
Voyager Therapeutics, Inc. |
Compositions for the treatment of disease
|
|
EP3448874A4
(en)
|
2016-04-29 |
2020-04-22 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
RU2725286C2
(ru)
|
2016-05-13 |
2020-06-30 |
4Д Молекьюлар Терапьютикс Инк. |
Варианты капсидов аденоассоциированного вируса и способы их применения
|
|
IL262784B2
(en)
|
2016-05-18 |
2023-10-01 |
Voyager Therapeutics Inc |
modulatory polynucleotides
|
|
SG11201809643UA
(en)
|
2016-05-18 |
2018-12-28 |
Voyager Therapeutics Inc |
Compositions and methods of treating huntington's disease
|
|
US11882815B2
(en)
|
2016-06-15 |
2024-01-30 |
University Of Massachusetts |
Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
|
|
CN106093369B
(zh)
*
|
2016-06-29 |
2017-10-20 |
福建农林大学 |
Bt水稻对非靶标害虫褐飞虱的安全性评价方法
|
|
NZ791267A
(en)
|
2016-08-15 |
2025-11-28 |
Genzyme Corp |
Methods for detecting AAV
|
|
WO2018044933A1
(en)
|
2016-08-30 |
2018-03-08 |
The Regents Of The University Of California |
Methods for biomedical targeting and delivery and devices and systems for practicing the same
|
|
US10457940B2
(en)
|
2016-09-22 |
2019-10-29 |
University Of Massachusetts |
AAV treatment of Huntington's disease
|
|
AU2017341849B2
(en)
|
2016-10-13 |
2024-03-21 |
University Of Massachusetts |
AAV capsid designs
|
|
EP3558393A4
(en)
*
|
2016-12-22 |
2020-11-11 |
Oregon Health & Science University |
ADENO-ASSOCIATED VIRAL VECTORS
|
|
WO2018204786A1
(en)
|
2017-05-05 |
2018-11-08 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
MX2019013172A
(es)
|
2017-05-05 |
2020-09-07 |
Voyager Therapeutics Inc |
Composiciones y metodos para tratar la enfermedad de huntington.
|
|
JOP20190269A1
(ar)
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
BR112020000063A2
(pt)
|
2017-07-06 |
2020-07-14 |
The Trustees Of The University Of Pennsylvania |
terapia gênica mediada por aav9 para tratamento de mucopolissacaridose tipo i
|
|
JP7229989B2
(ja)
|
2017-07-17 |
2023-02-28 |
ボイジャー セラピューティクス インコーポレイテッド |
軌道アレイガイドシステム
|
|
KR20250011726A
(ko)
|
2017-09-20 |
2025-01-21 |
4디 몰레큘러 테라퓨틱스 아이엔씨. |
아데노-관련 바이러스 변이체 캡시드 및 그 용도
|
|
EP3684932A1
(en)
|
2017-09-22 |
2020-07-29 |
Genzyme Corporation |
Variant rnai
|
|
AU2018335752B2
(en)
|
2017-09-22 |
2025-04-10 |
Christian HINDERER |
Gene therapy for treating Mucopolysaccharidosis type ii
|
|
MX2020003042A
(es)
|
2017-09-29 |
2020-11-18 |
Voyager Therapeutics Inc |
Rescate del fenotipo neurológico central y periférico de la ataxia de friedreich mediante administración intravenosa.
|
|
US11434502B2
(en)
|
2017-10-16 |
2022-09-06 |
Voyager Therapeutics, Inc. |
Treatment of amyotrophic lateral sclerosis (ALS)
|
|
WO2019079242A1
(en)
|
2017-10-16 |
2019-04-25 |
Voyager Therapeutics, Inc. |
TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
|
|
CR20200282A
(es)
|
2017-11-27 |
2021-02-18 |
4D Molecular Therapeutics Inc |
Cápsides variantes de virus adenoasociados y su uso para inhibir la angiogénesis
|
|
US10610606B2
(en)
|
2018-02-01 |
2020-04-07 |
Homology Medicines, Inc. |
Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
|
|
BR112020015798A2
(pt)
|
2018-02-01 |
2021-03-09 |
Homology Medicines, Inc. |
Composições de vírus adeno-associado para restaurar função de gene da pah e métodos de uso das mesmas
|
|
PE20210341A1
(es)
*
|
2018-02-01 |
2021-02-23 |
Homology Medicines Inc |
Composiciones de virus adeno-asociadas para la transferencia de genes pah y metodos de uso de los mismos
|
|
EP3755795A4
(en)
|
2018-02-19 |
2022-07-20 |
Homology Medicines, Inc. |
Adeno-associated virus compositions for restoring f8 gene function and methods of use thereof
|
|
BR112020020223A2
(pt)
|
2018-04-05 |
2021-01-19 |
Genethon |
Sorotipo de vírus adeno-associado híbrido recombinante entre aav9 e aavrh74 com tropismo pelo fígado reduzido
|
|
CN112601454B
(zh)
|
2018-04-16 |
2023-10-27 |
宾夕法尼亚州大学信托人 |
用于治疗杜兴肌营养不良的组合物和方法
|
|
WO2019213668A1
(en)
*
|
2018-05-04 |
2019-11-07 |
Oregon Health & Science University |
Human anti-aav2 capsid polyclonal antibody epitopes
|
|
EP3794126A1
(en)
|
2018-05-15 |
2021-03-24 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of parkinson's disease
|
|
WO2019236995A1
(en)
|
2018-06-08 |
2019-12-12 |
University Of Massachusetts |
Antisense oligonucleotides to restore dysferlin protein expression in dysferlinopathy patient cells
|
|
EP3807404A1
(en)
|
2018-06-13 |
2021-04-21 |
Voyager Therapeutics, Inc. |
Engineered 5' untranslated regions (5' utr) for aav production
|
|
JP2021530548A
(ja)
|
2018-07-24 |
2021-11-11 |
ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics, Inc. |
遺伝子治療製剤を生産するための系および方法
|
|
AR114540A1
(es)
|
2018-08-03 |
2020-09-16 |
Genzyme Corp |
VARIANTE DE ARNi CONTRA a-SINUCLEÍNA
|
|
SG11202103151RA
(en)
|
2018-09-28 |
2021-04-29 |
Voyager Therapeutics Inc |
Frataxin expression constructs having engineered promoters and methods of use thereof
|
|
TW202035689A
(zh)
|
2018-10-04 |
2020-10-01 |
美商航海家醫療公司 |
測量病毒載體粒子的效價及強度之方法
|
|
CN113166731A
(zh)
|
2018-10-05 |
2021-07-23 |
沃雅戈治疗公司 |
编码aav生产蛋白的工程化核酸构建体
|
|
EP3863662A1
(en)
|
2018-10-12 |
2021-08-18 |
Genzyme Corporation |
Generation of improved human pah for treatment of severe pku by liver-directed gene replacement therapy
|
|
UY38407A
(es)
|
2018-10-15 |
2020-05-29 |
Novartis Ag |
Anticuerpos estabilizadores de trem2
|
|
EP3867389A1
(en)
|
2018-10-15 |
2021-08-25 |
Voyager Therapeutics, Inc. |
Expression vectors for large-scale production of raav in the baculovirus/sf9 system
|
|
EP3917566A4
(en)
*
|
2019-01-31 |
2022-10-26 |
Oregon Health & Science University |
METHODS OF USING TRANSCRIPTION-DEPENDENT DIRECTED EVOLUTION OF AAV CAPSIDS
|
|
US20220154211A1
(en)
|
2019-02-25 |
2022-05-19 |
Novartis Ag |
Compositions and methods to treat bietti crystalline dystrophy
|
|
JP2022521025A
(ja)
|
2019-02-25 |
2022-04-04 |
ノバルティス アーゲー |
Biettiクリスタリン網膜症を治療するための組成物及び方法
|
|
WO2020176747A1
(en)
|
2019-02-28 |
2020-09-03 |
Regeneron Pharmaceuticals, Inc. |
Adeno-associated virus vectors for the delivery of therapeutics
|
|
US12398378B2
(en)
|
2019-04-12 |
2025-08-26 |
University Of Massachusetts |
AAV-mediated gene therapy for maple syrup urine disease (MSUD)
|
|
AU2020278960A1
(en)
*
|
2019-05-17 |
2021-12-23 |
Research Institute At Nationwide Children's Hospital |
Optimized gene therapy targeting retinal cells
|
|
US10801042B1
(en)
|
2019-07-15 |
2020-10-13 |
Vigene Biosciences, Inc. |
Use of ion concentrations to increase the packaging efficiency of recombinant adeno-associated virus
|
|
US10653731B1
(en)
|
2019-07-15 |
2020-05-19 |
Vigene Biosciences Inc. |
Recombinantly-modified adeno-associated virus (rAAV) having improved packaging efficiency
|
|
US10557149B1
(en)
|
2019-07-15 |
2020-02-11 |
Vigene Biosciences, Inc. |
Recombinantly-modified adeno-associated virus helper vectors and their use to improve the packaging efficiency of recombinantly-modified adeno-associated virus
|
|
EP4045525A1
(en)
*
|
2019-10-17 |
2022-08-24 |
Stridebio, Inc. |
Adeno-associated viral vectors for treatment of niemann-pick disease type c
|
|
CN115279419A
(zh)
*
|
2019-11-01 |
2022-11-01 |
美商圣加莫治疗股份有限公司 |
用于基因组工程的组合物和方法
|
|
TW202140791A
(zh)
|
2020-01-13 |
2021-11-01 |
美商霍蒙拉奇醫藥公司 |
治療苯酮尿症之方法
|
|
TW202208632A
(zh)
|
2020-05-27 |
2022-03-01 |
美商同源醫藥公司 |
用於恢復pah基因功能的腺相關病毒組成物及其使用方法
|
|
US12064894B2
(en)
|
2020-09-04 |
2024-08-20 |
Milwaukee Electric Tool Corporation |
Chainsaw
|
|
WO2022072657A1
(en)
|
2020-10-01 |
2022-04-07 |
Genzyme Corporation |
Human pah expression cassette for treatment of pku by liver-directed gene replacement therapy
|
|
AU2022214429A1
(en)
|
2021-02-01 |
2023-09-14 |
Tern Therapeutics, Llc |
Gene therapy for neuronal ceroid lipofuscinoses
|
|
US20240254483A1
(en)
|
2021-07-30 |
2024-08-01 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of frataxin (fxn)
|
|
WO2023010135A1
(en)
|
2021-07-30 |
2023-02-02 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
|
WO2023147304A1
(en)
*
|
2022-01-25 |
2023-08-03 |
The Trustees Of The University Of Pennsylvania |
Aav capsids for improved heart transduction and detargeting of liver
|
|
CA3255627A1
(en)
|
2022-05-06 |
2023-11-09 |
Novartis Ag |
NEW VP2 FUSION POLYPEPTIDES OF RECOMBINANT AAV
|
|
WO2024015881A2
(en)
|
2022-07-12 |
2024-01-18 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for targeted transcriptional activation
|
|
WO2024163683A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
|
|
WO2024163678A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
|
|
AR132545A1
(es)
|
2023-04-26 |
2025-07-16 |
Sanofi Sa |
Líneas celulares hospedadoras y métodos para identificar y usar dichas líneas celulares hospedadoras
|
|
WO2025128817A1
(en)
|
2023-12-15 |
2025-06-19 |
Genzyme Corporation |
Artificial micrornas targeting tau
|
|
WO2025160429A1
(en)
|
2024-01-26 |
2025-07-31 |
Genzyme Corporation |
Artificial micrornas targeting snca
|
|
WO2025160434A1
(en)
|
2024-01-26 |
2025-07-31 |
Genzyme Corporation |
Artificial micrornas targeting huntington's disease
|
|
US20250276095A1
(en)
|
2024-03-04 |
2025-09-04 |
Kate Therapeutics, Inc. |
Adeno-associated virus compositions for the treatment of duchenne muscular dystrophy
|
|
WO2025226842A1
(en)
|
2024-04-24 |
2025-10-30 |
Kate Therapeutics, Inc. |
Expression control by drg-expressed mirnas
|
|
WO2025226841A1
(en)
|
2024-04-24 |
2025-10-30 |
Kate Therapeutics, Inc. |
Gene therapy approach for treating disorders associated with tnnt2
|