AU2012219380B2 - Compositions and methods for altering tissue specificity and improving AAV9-mediated gene transfer - Google Patents

Compositions and methods for altering tissue specificity and improving AAV9-mediated gene transfer Download PDF

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Publication number
AU2012219380B2
AU2012219380B2 AU2012219380A AU2012219380A AU2012219380B2 AU 2012219380 B2 AU2012219380 B2 AU 2012219380B2 AU 2012219380 A AU2012219380 A AU 2012219380A AU 2012219380 A AU2012219380 A AU 2012219380A AU 2012219380 B2 AU2012219380 B2 AU 2012219380B2
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aav
aav9
galactose
vector
binding
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AU2012219380A1 (en
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Christie L. Bell
Luc H. Vandenberghe
James M. Wilson
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University of Pennsylvania
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University of Pennsylvania
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14041—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14045—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6027—Vectors comprising as targeting moiety peptide derived from defined protein from viruses ssDNA viruses

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  • Chemical & Material Sciences (AREA)
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  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2012219380A 2011-02-17 2012-02-17 Compositions and methods for altering tissue specificity and improving AAV9-mediated gene transfer Ceased AU2012219380B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161443879P 2011-02-17 2011-02-17
US61/443,879 2011-02-17
PCT/US2012/025550 WO2012112832A1 (en) 2011-02-17 2012-02-17 Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer

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AU2012219380A1 AU2012219380A1 (en) 2013-08-29
AU2012219380B2 true AU2012219380B2 (en) 2017-04-13

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EP (1) EP2675902B1 (enExample)
JP (1) JP6224459B2 (enExample)
KR (1) KR101956885B1 (enExample)
CN (1) CN103502458B (enExample)
AU (1) AU2012219380B2 (enExample)
BR (1) BR112013020734A2 (enExample)
CA (1) CA2826316C (enExample)
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ES (1) ES2724800T3 (enExample)
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