JP2012095652A5 - - Google Patents

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Publication number
JP2012095652A5
JP2012095652A5 JP2011268598A JP2011268598A JP2012095652A5 JP 2012095652 A5 JP2012095652 A5 JP 2012095652A5 JP 2011268598 A JP2011268598 A JP 2011268598A JP 2011268598 A JP2011268598 A JP 2011268598A JP 2012095652 A5 JP2012095652 A5 JP 2012095652A5
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JP
Japan
Prior art keywords
protein
recombinant
seq
set forth
hpv58
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JP2011268598A
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JP5616879B2 (ja
JP2012095652A (ja
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Publication of JP2012095652A5 publication Critical patent/JP2012095652A5/ja
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Claims (3)

  1. 組換えＨＰＶ５８ Ｌ１タンパク質を含むＨＰＶ５８ウイルス様粒子（ＶＬＰ）であって、該組換えＬ１タンパク質が配列番号２に記載のアミノ酸配列を含み、組換えＬ１タンパク質をコードする核酸分子の発現によって該組換えＬ１タンパク質が酵母内で生産される、ＨＰＶ５８ＶＬＰ。
  2. コドン最適化核酸分子が、配列番号１に記載のヌクレオチド配列を含む、請求項１記載のＶＬＰ。
  3. 配列番号２に記載のアミノ酸配列を含んでなる単離および精製されたＨＰＶ５８ Ｌ１ポリペプチド。
JP2011268598A 2003-11-12 2011-12-08 酵母におけるｈｐｖ５８ｌ１の最適化発現 Active JP5616879B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51921103P 2003-11-12 2003-11-12
US60/519,211 2003-11-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006539751A Division JP4912885B2 (ja) 2003-11-12 2004-11-10 酵母におけるｈｐｖ５８ｌ１の最適化発現

Publications (3)

Publication Number Publication Date
JP2012095652A JP2012095652A (ja) 2012-05-24
JP2012095652A5 true JP2012095652A5 (ja) 2013-03-14
JP5616879B2 JP5616879B2 (ja) 2014-10-29

Family

ID=34590374

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006539751A Active JP4912885B2 (ja) 2003-11-12 2004-11-10 酵母におけるｈｐｖ５８ｌ１の最適化発現
JP2011268598A Active JP5616879B2 (ja) 2003-11-12 2011-12-08 酵母におけるｈｐｖ５８ｌ１の最適化発現

Family Applications Before (1)

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JP2006539751A Active JP4912885B2 (ja) 2003-11-12 2004-11-10 酵母におけるｈｐｖ５８ｌ１の最適化発現

Country Status (32)

Country Link
US (2) US7498036B2 (ja)
EP (1) EP1687329B8 (ja)
JP (2) JP4912885B2 (ja)
KR (1) KR101170654B1 (ja)
CN (1) CN1942583B (ja)
AR (1) AR046835A1 (ja)
AT (1) ATE452977T1 (ja)
AU (1) AU2004290032B2 (ja)
BE (1) BE2015C070I2 (ja)
BR (1) BRPI0416393B1 (ja)
CA (1) CA2543928C (ja)
CY (2) CY1113875T1 (ja)
DE (1) DE602004024821D1 (ja)
DK (1) DK1687329T3 (ja)
ES (1) ES2340287T3 (ja)
FR (1) FR15C0081I2 (ja)
HU (1) HUS1500064I1 (ja)
IL (1) IL175353A (ja)
IS (1) IS2741B (ja)
LT (1) LTC1687329I2 (ja)
LU (1) LU92901I2 (ja)
MY (1) MY139500A (ja)
NL (1) NL300775I2 (ja)
NO (2) NO340633B1 (ja)
NZ (1) NZ546697A (ja)
PL (1) PL1687329T3 (ja)
PT (1) PT1687329E (ja)
RU (1) RU2370538C2 (ja)
SI (1) SI1687329T1 (ja)
TW (1) TWI332988B (ja)
WO (1) WO2005047315A2 (ja)
ZA (1) ZA200603106B (ja)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858098B2 (en) * 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
US8206950B2 (en) 2003-06-09 2012-06-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine and method of making them
PL1730175T3 (pl) 2004-03-24 2010-09-30 Merck Sharp & Dohme Optymalizowana ekspresja L1 HPV 52 w drożdżach
US20070243587A1 (en) * 2006-04-14 2007-10-18 Healthbanks Biotech Co., Ltd. Using a reverse genetic engineering platform to produce protein vaccines and protein vaccine of avian influenza virus
CN101148661B (zh) * 2006-09-18 2013-01-02 中国医学科学院基础医学研究所 人乳头瘤病毒16型外壳蛋白病毒样颗粒及其制备方法和用途
US7709010B2 (en) * 2007-03-09 2010-05-04 Merck Sharp & Dohme Corp. Papillomavirus vaccine compositions
US9428555B2 (en) 2007-04-29 2016-08-30 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated L1 protein of Human Papillomavirus type 16
BRPI0815818A2 (pt) 2007-04-29 2016-08-02 Beijing Wantai Biological Pharmacy Entpr Co Ltd proteína l1 truncada do papiloma vírus humano tipo 18
EP2154149B1 (en) * 2007-05-29 2019-07-10 Xiamen University A truncated l1 protein of human papillomavirus 6
CN101113417B (zh) * 2007-06-22 2011-04-27 山东大学 Hpv基因酵母体外翻译系统的建立
CN101200696B (zh) * 2007-11-14 2011-07-20 山东大学 人乳头瘤病毒的酵母增殖模型及建立方法与应用
WO2009076824A1 (zh) * 2007-11-23 2009-06-25 Shanghai Zerun Biotechnology Co., Ltd. 人乳头状瘤病毒主要衣壳蛋白l1基因及其用途
KR20090073987A (ko) * 2007-12-31 2009-07-03 정운원 인간유두종바이러스 유전자형 검사를 위한 프라이머, 프로브 및 이를 포함하는 ｄｎａ칩, 이의 검사 방법 및 검사 키트
TWI561244B (en) * 2008-05-26 2016-12-11 Cadila Healthcare Ltd Combined measles-human papilloma vaccine
US9335868B2 (en) * 2008-07-31 2016-05-10 Apple Inc. Capacitive sensor behind black mask
JP6153866B2 (ja) 2010-05-25 2017-06-28 キアゲン ガイサーズバーグ アイエヌシー． 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ
CN101857870B (zh) * 2010-06-12 2012-09-05 上海泽润生物科技有限公司 Hpv58 l1基因及载体、菌株和表达方法
WO2012006962A1 (zh) * 2010-07-16 2012-01-19 厦门大学 截短的人乳头瘤病毒58型l1蛋白
CN102154325B (zh) * 2011-01-01 2013-08-21 上海生物制品研究所有限责任公司 针对人乳头瘤状病毒的疫苗及其制法和用途
CN103717741B (zh) * 2011-06-15 2016-04-13 中央大学校产学协力团 用于提高人乳头瘤病毒l1蛋白产量的方法
CN108624614A (zh) * 2012-03-28 2018-10-09 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv11 l1蛋白的方法
EP2858680B1 (en) * 2012-06-07 2018-10-31 The Children's Hospital of Philadelphia Controlled gene expression methods
CN103992395B (zh) * 2013-02-18 2018-07-27 北京康乐卫士生物技术股份有限公司 重组hpv-58型l1的vlp疫苗及其制备方法
CN110423774A (zh) * 2013-04-26 2019-11-08 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv58 l1蛋白的方法
CN104164374B (zh) * 2013-05-17 2019-10-22 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv31 l1蛋白的方法
CN104164373B (zh) * 2013-05-17 2019-04-02 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv68l1蛋白的方法
CA2927434C (en) 2013-10-16 2022-07-19 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
WO2016038625A2 (en) * 2014-09-11 2016-03-17 Cadila Healthcare Limited Superior human papilloma virus antigens with superior immunological properties and vaccine containing it
CN106148359A (zh) * 2015-03-30 2016-11-23 上海泽润生物科技有限公司 重组人乳头瘤病毒33亚型蛋白表达
CN104878022A (zh) * 2015-04-27 2015-09-02 段青姣 编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用
WO2017092710A1 (zh) * 2015-12-04 2017-06-08 厦门大学 一种人乳头瘤病毒58型l1蛋白的突变体
PE20230493A1 (es) 2020-02-14 2023-03-23 Merck Sharp And Dohme Llc Vacuna contra hpv
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
CN113549634B (zh) * 2021-06-07 2023-03-31 郑州大学 编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用
AR126708A1 (es) 2021-08-06 2023-11-08 Merck Sharp & Dohme Llc Vacuna para el vph
TW202315602A (zh) 2021-08-19 2023-04-16 美商默沙東有限責任公司 新穎熱穩定脂質奈米粒子及其使用方法
CN117054647A (zh) * 2023-07-17 2023-11-14 广东省一鼎生物技术有限公司 一种检测HPV IgG抗体试剂盒及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117591A0 (en) * 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
US5821087A (en) * 1995-03-30 1998-10-13 Merck & Co., Inc. Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA
AU743616B2 (en) 1997-02-07 2002-01-31 Merck & Co., Inc. Synthetic HIV gag genes
WO1999002694A1 (en) 1997-07-09 1999-01-21 The University Of Queensland Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue
KR20010072470A (ko) * 1998-08-14 2001-07-31 폴락 돈나 엘. 사람 유두종바이러스 바이러스-유사 입자의 정제방법
EP1105157B1 (en) 1998-08-14 2006-11-02 Merck & Co., Inc. Protein delivery system using human papillomavirus virus-like particles
SE514982C2 (sv) * 1999-09-30 2001-05-28 Active Biotech Ab Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning
WO2001014416A2 (en) * 1999-08-25 2001-03-01 Merck & Co., Inc. Synthetic papillomavirus genes optimized for expression in human cells
US6436402B1 (en) 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
US7026443B1 (en) * 1999-12-10 2006-04-11 Epimmune Inc. Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
DE60124918T2 (de) 2000-07-21 2007-08-02 Glaxo Group Ltd., Greenford Kodon-optimierte papillomavirussequenzen
AU2003213065A1 (en) * 2002-02-14 2003-09-04 Novavax, Inc. Novel insect cell line
CA2519112C (en) * 2003-03-24 2012-09-11 Merck & Co., Inc. Optimized expression of hpv 31 l1 in yeast
MY140664A (en) 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast

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