AR126708A1 - Vacuna para el vph - Google Patents

Vacuna para el vph

Info

Publication number
AR126708A1
AR126708A1 ARP220102097A ARP220102097A AR126708A1 AR 126708 A1 AR126708 A1 AR 126708A1 AR P220102097 A ARP220102097 A AR P220102097A AR P220102097 A ARP220102097 A AR P220102097A AR 126708 A1 AR126708 A1 AR 126708A1
Authority
AR
Argentina
Prior art keywords
hpv
vlps
chitosan
type
composition
Prior art date
Application number
ARP220102097A
Other languages
English (en)
Inventor
Andrew Bett
John P Bilello
Pedro J Cejas
Amy S Espeseth
Tong Fu
- Strable Erica Leigh Ming
Colleen M Barr
Sara Zimmermann
Original Assignee
Merck Sharp & Dohme Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Llc filed Critical Merck Sharp & Dohme Llc
Publication of AR126708A1 publication Critical patent/AR126708A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20071—Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente divulgación proporciona, entre otras cosas, una composición de vacuna de dosis única que incluye un adyuvante de quitosano y partículas similivíricas del PVH (las VLP) de al menos un tipo del papilomavirus humano (PVH) seleccionado del grupo que consiste en los tipos del PVH: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73 y 82, en que la composición de vacuna de dosis única proporciona una respuesta de vacuna para el PVH potenciada o comparable en comparación con una vacuna de dosis múltiples similar formulada sin tal adyuvante de quitosano. Reivindicación 1: Una composición farmacéutica que comprende: partículas similivíricas (las VLP) de al menos un tipo del papilomavirus humano (PVH) seleccionado del grupo que consiste en los tipos del PVH: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 5 51, 52, 53, 55, 56, 58, 59, 66, 68, 69, 70, 73 y 82, un quitosano; y un transportador farmacéuticamente aceptable. Reivindicación 42: Una composición farmacéutica que comprende partículas similivíricas (las VLP) de al menos un tipo del papilomavirus humano (PVH), en donde el al menos un tipo del PVH se selecciona del grupo que consiste en los tipos del PVH: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73 y 82; y 0,1 mg a aproximadamente 50 mg de un quitosano, en donde las VLP de PVH comprenden proteína Ll del PVH recombinante o proteína L1 + L2 del PVH recombinante, en donde las VLP de PVH de cada uno de los al menos uno de los tipos del PVH están presentes en una concentración de aproximadamente 10 mg a aproximadamente 300 mg por 0,5 ml de la composición farmacéutica, y en donde la concentración total de VLP está entre 10 mg y 2000 mg por 0,5 ml de la composición farmacéutica. Reivindicación 75: Una composición de vacuna de dosis única que comprende: un quitosano, partículas similivíricas (las VLP) de al menos un tipo del papilomavirus humano (PVH) seleccionado del grupo que consiste en los tipos del PVH: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73 y 82, y un transportador farmacéuticamente aceptable; en donde la composición de vacuna de dosis única proporciona una respuesta inmunitaria anti-PVH elevada o comparable con respecto a dosis múltiples de la misma composición formulada sin un adyuvante de quitosano.
ARP220102097A 2021-08-06 2022-08-04 Vacuna para el vph AR126708A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202163230426P 2021-08-06 2021-08-06

Publications (1)

Publication Number Publication Date
AR126708A1 true AR126708A1 (es) 2023-11-08

Family

ID=83193593

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220102097A AR126708A1 (es) 2021-08-06 2022-08-04 Vacuna para el vph

Country Status (5)

Country Link
US (1) US20230048144A1 (es)
EP (1) EP4380615A1 (es)
AR (1) AR126708A1 (es)
TW (1) TW202313658A (es)
WO (1) WO2023014853A1 (es)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5437951A (en) 1992-09-03 1995-08-01 The United States Of America As Represented By The Department Of Health And Human Services Self-assembling recombinant papillomavirus capsid proteins
WO1996011272A2 (de) 1994-10-07 1996-04-18 Medigene Gesellschaft Für Molekularbiologische Diagnostik, Theraphie Und Technologie Mbh Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung
US5820870A (en) 1995-03-22 1998-10-13 Merck & Co., Inc. Recombinant human papillomavirus type 18 vaccine
EP1608767B1 (en) 2003-03-24 2012-02-22 Merck Sharp & Dohme Corp. Optimized expression of hpv 31 l1 in yeast
MY140664A (en) 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast
MY139500A (en) 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
CN1934131B (zh) 2004-03-24 2010-12-29 默沙东公司 Hpv52l1在酵母中的优化表达
EP1877086A2 (en) 2005-04-26 2008-01-16 GlaxoSmithKline Biologicals SA Vaccine
CN109464661B (zh) * 2018-12-14 2022-05-10 中国科学院过程工程研究所 一种疫苗抗原组合物及其制备方法

Also Published As

Publication number Publication date
WO2023014853A1 (en) 2023-02-09
EP4380615A1 (en) 2024-06-12
US20230048144A1 (en) 2023-02-16
TW202313658A (zh) 2023-04-01

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