JP2007175057A5 - - Google Patents

Download PDF

Info

Publication number
JP2007175057A5
JP2007175057A5 JP2007026119A JP2007026119A JP2007175057A5 JP 2007175057 A5 JP2007175057 A5 JP 2007175057A5 JP 2007026119 A JP2007026119 A JP 2007026119A JP 2007026119 A JP2007026119 A JP 2007026119A JP 2007175057 A5 JP2007175057 A5 JP 2007175057A5
Authority
JP
Japan
Prior art keywords
galactosyltransferase
porcine
disrupted
seq
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007026119A
Other languages
English (en)
Other versions
JP2007175057A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2007175057A publication Critical patent/JP2007175057A/ja
Publication of JP2007175057A5 publication Critical patent/JP2007175057A5/ja
Pending legal-status Critical Current

Links

Claims (4)

  1. 配列番号1に示されるアミノ酸配列からなるα(1,3)ガラクトシルトランスフェラーゼをコードする遺伝子が破壊され、それにより機能的なα(1,3)ガラクトシルトランスフェラーゼの発現が阻害されていることを特徴とするブタ細胞を含むブタ組織。
  2. 前記遺伝子が相同的組換えにより破壊されることを特徴とする、請求項1に記載のブタ組織。
  3. Galα1−3Galα1−4GlcNacエピトープが細胞表面に存在しないブタ細胞を含むことを特徴とする、請求項1に記載のブタ組織。
  4. 配列識別番号1に示されるアミノ酸配列からなるα(1,3)ガラクトシルトランスフェラーゼをコードする核酸分子。
JP2007026119A 1994-04-13 2007-01-10 α(1,3)ガラクトシルトランスフェラーゼ陰性ブタ Pending JP2007175057A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22893394A 1994-04-13 1994-04-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP7526984A Division JPH10504442A (ja) 1994-04-13 1995-03-31 α(1,3)ガラクトシルトランスフェラーゼ陰性ブタ

Publications (2)

Publication Number Publication Date
JP2007175057A JP2007175057A (ja) 2007-07-12
JP2007175057A5 true JP2007175057A5 (ja) 2007-08-23

Family

ID=22859145

Family Applications (2)

Application Number Title Priority Date Filing Date
JP7526984A Pending JPH10504442A (ja) 1994-04-13 1995-03-31 α(1,3)ガラクトシルトランスフェラーゼ陰性ブタ
JP2007026119A Pending JP2007175057A (ja) 1994-04-13 2007-01-10 α(1,3)ガラクトシルトランスフェラーゼ陰性ブタ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP7526984A Pending JPH10504442A (ja) 1994-04-13 1995-03-31 α(1,3)ガラクトシルトランスフェラーゼ陰性ブタ

Country Status (9)

Country Link
US (3) US6153428A (ja)
EP (1) EP0755402B1 (ja)
JP (2) JPH10504442A (ja)
AT (1) ATE395418T1 (ja)
AU (1) AU2233295A (ja)
CA (1) CA2187802A1 (ja)
DE (1) DE69535752D1 (ja)
IL (1) IL113238A0 (ja)
WO (1) WO1995028412A1 (ja)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331658B1 (en) * 1993-04-20 2001-12-18 Integris Baptist Medical Center, Inc. Genetically engineered mammals for use as organ donors
US5849991A (en) * 1994-01-27 1998-12-15 Bresatch Limited Mice homozygous for an inactivated α 1,3-galactosyl transferase gene
CA2196311A1 (en) * 1994-08-19 1996-02-29 David H. Sachs Genetically engineered swine cells
US5865849A (en) * 1995-06-07 1999-02-02 Crosscart, Inc. Meniscal heterografts
US6046379A (en) * 1995-06-07 2000-04-04 Stone; Kevin R. Meniscal xenografts
US5913900A (en) * 1995-06-07 1999-06-22 Corsscart, Inc. Substantially native meniscal cartilage heterografts
US6231608B1 (en) 1995-06-07 2001-05-15 Crosscart, Inc. Aldehyde and glycosidase-treated soft and bone tissue xenografts
US5984858A (en) * 1995-06-07 1999-11-16 Crosscart, Inc. Meniscal xenografts
US5902338A (en) * 1995-09-15 1999-05-11 Crosscart, Inc. Anterior cruciate ligament heterograft
US6049025A (en) * 1995-09-15 2000-04-11 Stone; Kevin R. Articular cartilage xenografts
US6110206A (en) * 1995-09-15 2000-08-29 Crosscart, Inc. Anterior cruciate ligament xenografts
US6210440B1 (en) 1995-09-15 2001-04-03 Kevin R. Stone Anterior cruciate ligament xenografts
US5782915A (en) * 1995-09-15 1998-07-21 Stone; Kevin R. Articular cartilage heterografts
US5944755A (en) * 1995-09-15 1999-08-31 Crosscart, Inc. Articular cartilage xenografts
US6166288A (en) * 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
AU7668696A (en) * 1995-11-03 1997-05-22 Austin Research Institute, The Methods and compositions for the reduction of xenotransplantation rejection
US6235969B1 (en) * 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US6011197A (en) 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
CA2349562A1 (en) 1998-03-06 1999-09-10 Crosscart, Inc. Soft tissue xenografts
US6972041B1 (en) 1998-03-16 2005-12-06 Crosscart, Inc. Bone xenografts
US6383732B1 (en) 1999-02-11 2002-05-07 Crosscart, Inc. Method of preparing xenograft heart valves
US6509187B2 (en) * 1998-05-25 2003-01-21 Agrobiogen Gmbh Method and device for collection and preparation of tissue samples for molecular genetic diagnostics
JP2990268B1 (ja) * 1998-08-31 1999-12-13 工業技術院長 機能性核酸転写用発現系
DE59904870D1 (de) * 1998-09-25 2003-05-08 Deutsches Krebsforsch Antisense-sequenzen für die hemmung der expression des adhäsionsmoleküls icam-1
AU6218899A (en) 1998-10-12 2000-05-01 Geron Bio-Med Limited Porcine oocytes with improved developmental competence
WO2000024912A1 (en) * 1998-10-23 2000-05-04 The Children's Medical Center Corporation Use of a self-cleaving rna motif to modulate gene expression
US6700037B2 (en) 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US6258998B1 (en) 1998-11-24 2001-07-10 Infigen, Inc. Method of cloning porcine animals
US6267786B1 (en) 1999-02-11 2001-07-31 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
US20020012660A1 (en) * 1999-03-04 2002-01-31 Alan Colman Method of preparing a somatic cells for nuclear transfer
AU7744800A (en) * 1999-09-30 2001-04-30 Alexion Pharmaceuticals, Inc. Compositions and methods for altering gene expression
WO2001030992A2 (en) * 1999-10-22 2001-05-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education α1-3 GALACTOSYLTRANSFERASE GENE AND PROMOTER
US7820878B2 (en) 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
WO2001035735A1 (en) * 1999-11-19 2001-05-25 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
EP1356035B1 (en) 2000-12-22 2011-03-16 Kyowa Hakko Kirin Co., Ltd. Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells
US20020142397A1 (en) * 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
US7126039B2 (en) 2001-03-21 2006-10-24 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
EP1373498A2 (en) * 2001-03-21 2004-01-02 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
US20030153044A1 (en) * 2001-05-14 2003-08-14 Monika Liljedahl Tissues or organs for use in xenotransplantation
US20030092174A1 (en) * 2001-05-14 2003-05-15 Monika Liljedahl Tissues or organs for use in xenotransplantation
US6702744B2 (en) 2001-06-20 2004-03-09 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
US20030101469A1 (en) * 2001-07-09 2003-05-29 Kenneth Bondioli Cloned non-human mammals from contact inhibited donor cells
US8608661B1 (en) 2001-11-30 2013-12-17 Advanced Cardiovascular Systems, Inc. Method for intravascular delivery of a treatment agent beyond a blood vessel wall
CA2471035C (en) * 2001-12-21 2014-05-13 The Curators Of The University Of Missouri Knockout swine and methods for making the same
JP2003225089A (ja) * 2002-02-04 2003-08-12 National Institute Of Agrobiological Sciences ブタrag−1遺伝子およびその利用
US7361368B2 (en) 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
WO2004016742A2 (en) * 2002-08-14 2004-02-26 Immerge Biotherapeutics, Inc. α(1,3)-GALACTOSYLTRANSFERASE NULL CELLS, METHODS OF SELECTING AND α(1,3)-GALACTOSYLTRANSFERASE NULL SWINE PRODUCED THEREFROM
CA2496761C (en) * 2002-08-21 2015-06-02 Revivicor, Inc. Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
AU2003290689A1 (en) * 2002-11-08 2004-06-03 Kyowa Hakko Kirin Co., Ltd. Transgenic ungulates having reduced prion protein activity and uses thereof
US7641643B2 (en) 2003-04-15 2010-01-05 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8038991B1 (en) 2003-04-15 2011-10-18 Abbott Cardiovascular Systems Inc. High-viscosity hyaluronic acid compositions to treat myocardial conditions
WO2005009134A1 (en) 2003-07-21 2005-02-03 Lifecell Corporation ACELLULAR TISSUE MATRICES MADE FROM GALACTOSE α-1,3-GALACTOSE-DEFICIENT TISSUE
EP1685148A2 (en) 2003-11-05 2006-08-02 University Of Pittsburgh Of The Commonwealth System Of Higher Education PORCINE ISOGLOBOSIDE 3 SYNTHASE PROTEIN, cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION
CA2559720A1 (en) 2004-03-17 2005-09-29 Revivicor, Inc. Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase
NZ550106A (en) 2004-04-22 2009-06-26 Kyowa Hakko Kirin Co Ltd Transgenic animals and uses thereof
WO2005117576A2 (en) * 2004-05-28 2005-12-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education Modification of sugar metabolic process in transgenic cells, tissues and animals
US20060147429A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Facilitated cellular reconstitution of organs and tissues
US20060148080A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Methods for supporting and producing human cells and tissues in non-human mammal hosts
US8303972B2 (en) 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8828433B2 (en) 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US8187621B2 (en) 2005-04-19 2012-05-29 Advanced Cardiovascular Systems, Inc. Methods and compositions for treating post-myocardial infarction damage
US7732190B2 (en) 2006-07-31 2010-06-08 Advanced Cardiovascular Systems, Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US8741326B2 (en) 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
WO2009069986A2 (en) 2007-11-30 2009-06-04 Korea Research Institute Of Bioscience And Biotechnology Genetically-modified cell line for producing cloned miniature pigs for xenotransplantation and method for preparing the same.
KR101178946B1 (ko) 2008-02-01 2012-09-03 한국생명공학연구원 알파 1,3-갈락토실트랜스퍼라아제 유전자 타겟팅 벡터
KR101068479B1 (ko) 2008-07-30 2011-09-29 한국생명공학연구원 알파 1,3-갈락토실트랜스퍼라아제 유전자 타겟팅 벡터 및그의 용도
KR20180036810A (ko) 2009-08-14 2018-04-09 레비비코르 인코포레이션 당뇨병 치료를 위한 복수 형질전환 돼지
CN103492576A (zh) 2011-02-14 2014-01-01 雷维维科公司 用于血管化异种移植物及其衍生物的异种移植的遗传修饰的猪
US9883939B2 (en) 2012-05-08 2018-02-06 The General Hospital Corporation Reducing immunogenicity of xenogeneic transplant tissues
WO2013188358A1 (en) 2012-06-12 2013-12-19 The General Hospital Corporation Miniature swine transgenic for one or more coagulation factors
BR112016009178B1 (pt) 2013-11-04 2020-12-15 Lifecell Corporation Método de preparação de um produto de tecido e uso de um produto de tecido
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
WO2020072982A1 (en) 2018-10-05 2020-04-09 Xenotherapeutics, Inc. Xenotransplantation products and methods
WO2022109316A1 (en) 2020-11-20 2022-05-27 Revivicor, Inc. Multi-transgenic pigs with growth hormone receptor knockout for xenotransplantation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0689597A4 (en) * 1993-03-16 1998-10-21 Austin Research Inst USE OF PIG GAL-g (a) (1,3) GALACTOSYL TRANSFERASE FOR XENOGENE THERAPIES
US5849991A (en) * 1994-01-27 1998-12-15 Bresatch Limited Mice homozygous for an inactivated α 1,3-galactosyl transferase gene

Similar Documents

Publication Publication Date Title
JP2007175057A5 (ja)
JP2006149395A5 (ja)
RU2007141683A (ru) Вариантная форма урат-оксидазы и ее использование
JP2009268467A5 (ja)
JP2010273685A5 (ja)
JP2010065037A5 (ja)
JP2010227108A5 (ja)
JP2009509509A5 (ja)
JP2011511933A5 (ja)
JP2008237210A5 (ja)
JP2005120106A5 (ja)
WO2010037836A3 (en) Cross-species-specific psmaxcd3 bispecific single chain antibody
JP2010088434A5 (ja)
WO2008093847A1 (ja) キシリトールデヒドロゲナーゼをコードするdna
JP2010534684A5 (ja)
JP2010523099A5 (ja)
JP2009527226A5 (ja)
JP2018521630A5 (ja)
JP2010530223A5 (ja)
JP2016513457A5 (ja)
JP2010532656A5 (ja)
EP1726655A4 (en) BETA-fructofuranosidase MUTANT
WO2014203261A3 (en) Recombinant lectin and method of preparing thereof
WO2009047992A1 (ja) Udp-グルクロン酸転移酵素およびそれをコードするポリヌクレオチド
EP2434018A3 (en) A novel beta-galactoside-alpha2, 3-sialyltransferase, a gene encoding thereof, and a method for producing thereof