JP2011152137A5 - - Google Patents
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- Publication number
- JP2011152137A5 JP2011152137A5 JP2011045589A JP2011045589A JP2011152137A5 JP 2011152137 A5 JP2011152137 A5 JP 2011152137A5 JP 2011045589 A JP2011045589 A JP 2011045589A JP 2011045589 A JP2011045589 A JP 2011045589A JP 2011152137 A5 JP2011152137 A5 JP 2011152137A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- hpv45
- protein
- yeast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 9
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 2
- 235000014663 Kluyveromyces fragilis Nutrition 0.000 claims 2
- 241001138401 Kluyveromyces lactis Species 0.000 claims 2
- 241000235650 Kluyveromyces marxianus Species 0.000 claims 2
- 241000235058 Komagataella pastoris Species 0.000 claims 2
- 241000320412 Ogataea angusta Species 0.000 claims 2
- 241001631646 Papillomaviridae Species 0.000 claims 2
- 241000235347 Schizosaccharomyces pombe Species 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50681203P | 2003-09-29 | 2003-09-29 | |
| US60/506,812 | 2003-09-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528190A Division JP5451960B2 (ja) | 2003-09-29 | 2004-09-24 | 酵母におけるｈｐｖ４５ｌ１の最適化された発現 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014129350A Division JP2014221052A (ja) | 2003-09-29 | 2014-06-24 | 酵母におけるｈｐｖ４５ｌ１の最適化された発現 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011152137A JP2011152137A (ja) | 2011-08-11 |
| JP2011152137A5 true JP2011152137A5 (enExample) | 2013-04-04 |
Family
ID=34421558
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528190A Expired - Lifetime JP5451960B2 (ja) | 2003-09-29 | 2004-09-24 | 酵母におけるｈｐｖ４５ｌ１の最適化された発現 |
| JP2011045589A Pending JP2011152137A (ja) | 2003-09-29 | 2011-03-02 | 酵母におけるｈｐｖ４５ｌ１の最適化された発現 |
| JP2014129350A Pending JP2014221052A (ja) | 2003-09-29 | 2014-06-24 | 酵母におけるｈｐｖ４５ｌ１の最適化された発現 |
| JP2016019712A Pending JP2016136947A (ja) | 2003-09-29 | 2016-02-04 | 酵母におけるｈｐｖ４５ｌ１の最適化された発現 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528190A Expired - Lifetime JP5451960B2 (ja) | 2003-09-29 | 2004-09-24 | 酵母におけるｈｐｖ４５ｌ１の最適化された発現 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014129350A Pending JP2014221052A (ja) | 2003-09-29 | 2014-06-24 | 酵母におけるｈｐｖ４５ｌ１の最適化された発現 |
| JP2016019712A Pending JP2016136947A (ja) | 2003-09-29 | 2016-02-04 | 酵母におけるｈｐｖ４５ｌ１の最適化された発現 |
Country Status (33)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0206360D0 (en) | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| US7858098B2 (en) * | 2002-12-20 | 2010-12-28 | Glaxosmithkline Biologicals, S.A. | Vaccine |
| MY139500A (en) | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
| ES2343255T3 (es) | 2004-03-24 | 2010-07-27 | MERCK SHARP & DOHME CORP. | Expresion optimizada del vph 52 l1 en levadura. |
| US7758866B2 (en) | 2004-06-16 | 2010-07-20 | Glaxosmithkline Biologicals, S.A. | Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52 |
| CA2604909A1 (en) | 2005-04-15 | 2006-10-26 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services | Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen |
| EP1877086A2 (en) * | 2005-04-26 | 2008-01-16 | GlaxoSmithKline Biologicals SA | Vaccine |
| KR100904844B1 (ko) * | 2006-08-28 | 2009-06-25 | 성균관대학교산학협력단 | 인유두종 바이러스（ｈｐｖ）유전자를 포함하는자궁경부암의 치료 또는 예방용 ｄｎａ 백신 |
| WO2008112125A1 (en) * | 2007-03-09 | 2008-09-18 | Merck & Co., Inc. | Papillomavirus vaccine compositions |
| MY182347A (en) * | 2007-11-23 | 2021-01-20 | Shanghai Zerun Biotechnology Co Ltd | Genes encoding major capsid protein l1 of human papilloma virus and use of the same |
| AU2009348078B2 (en) | 2009-06-19 | 2013-03-14 | Eyegene Inc. | Vaccine for cervical cancer |
| EP2576840B1 (en) | 2010-05-25 | 2018-10-17 | QIAGEN Gaithersburg, Inc. | Fast results hybrid capture assay and associated strategically-truncated probes |
| EP2722389B1 (en) | 2011-06-15 | 2018-03-07 | Hong Jin Kim | Method for enhancing the production yield of human papillomavirus l1 protein |
| WO2012177970A1 (en) | 2011-06-24 | 2012-12-27 | Merck Sharp & Dohme Corp. | Hpv vaccine formulations comprising aluminum adjuvant and methods of producing same |
| CN109321592A (zh) * | 2012-01-21 | 2019-02-12 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv18 l1蛋白的方法 |
| CN108624614A (zh) * | 2012-03-28 | 2018-10-09 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv11 l1蛋白的方法 |
| CN110484554B (zh) * | 2013-04-26 | 2024-04-16 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv52 l1蛋白的方法 |
| CN104120088B (zh) * | 2013-04-26 | 2019-09-24 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv58 l1蛋白的方法 |
| CN110295190A (zh) * | 2013-05-17 | 2019-10-01 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv45 l1蛋白的方法 |
| CN112280792B (zh) * | 2013-09-29 | 2022-06-24 | 上海泽润生物科技有限公司 | 人乳头瘤病毒基因，及载体，菌株，表达方法 |
| EP3057612B1 (en) | 2013-10-16 | 2020-05-06 | Merck Sharp & Dohme Corp. | Method of obtaining thermostable dried vaccine formulations |
| EA201790365A1 (ru) * | 2014-09-11 | 2017-07-31 | Кадила Хелзкэр Лимитед | Антигены вируса папилломы человека с хорошими иммунологическими свойствами и содержащая их вакцина |
| CN106282278B (zh) * | 2015-06-29 | 2021-06-08 | 广东东阳光药业有限公司 | 一种人乳头瘤病毒l1蛋白的发酵方法 |
| CN106701798B (zh) * | 2015-08-12 | 2021-09-17 | 北京康乐卫士生物技术股份有限公司 | 45型重组人乳头瘤病毒病毒样颗粒及其制备方法 |
| CN109750050B (zh) * | 2017-11-07 | 2023-08-18 | 上海泽润生物科技有限公司 | 重组人乳头瘤病毒45亚型蛋白表达 |
| US11638754B2 (en) | 2020-02-14 | 2023-05-02 | Merck Sharp & Dohme Llc | HPV vaccine |
| CN112680462B (zh) * | 2020-12-29 | 2022-02-22 | 上海博唯生物科技有限公司 | 一种人乳头瘤病毒35型/hpv35型l1/l2及其制备与应用 |
| CN113073105B (zh) * | 2021-03-23 | 2023-06-13 | 重庆博唯佰泰生物制药有限公司 | 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用 |
| US20230048144A1 (en) | 2021-08-06 | 2023-02-16 | Merck Sharp & Dohme Llc | Hpv vaccine |
| MX2024002144A (es) | 2021-08-19 | 2024-04-23 | Merck Sharp & Dohme Llc | Nueva nanoparticula lipidica termostable y metodos de uso de la misma. |
| TW202513091A (zh) | 2023-06-09 | 2025-04-01 | 美商默沙東有限責任公司 | 用於人類乳突病毒疫苗之奈米乳液佐劑組合物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9507657A (pt) * | 1994-05-16 | 1997-09-09 | Merck & Co Inc | Proteina isolada e purificada de papilomavirus recombinante capsideos particulas semelhantes a virus processos a virus processos para produzir a proteina para tratar ou prevenir a infecçao por papilomavirus para produzir uma proteina de capsideo de papilomavirus recombinante montada em um capsideo ou particula semelhante a virus e para induzir uma resposta imune em um animal vertebrado composiçoes farmacêuticas kit para a detecçao de papilomavirus ou anticorpos para papilomavirus e sistema sinte |
| AR004464A1 (es) * | 1994-11-14 | 1998-12-16 | Merck Sharp & Dohme | Un metodo para producir una proteina de capside de papilomavirus |
| IL117459A (en) * | 1995-03-22 | 2005-11-20 | Merck & Co Inc | Dna encoding human papillomavirus type 18 |
| IL117591A0 (en) * | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
| JP2001512308A (ja) | 1997-02-07 | 2001-08-21 | メルク エンド カンパニー インコーポレーテッド | 合成ｈｉｖ ｇａｇ遺伝子 |
| EP1015612B1 (en) * | 1997-05-27 | 2005-01-26 | Hanil Synthetic Fiber Co., Ltd. | Process for preparing recombinant proteins using highly efficient expression vector from saccharomyces cerevisiae |
| EP1002091B1 (en) | 1997-07-09 | 2012-02-29 | Coridon Pty Limited | Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue |
| US6991795B1 (en) * | 1998-08-14 | 2006-01-31 | Merck & Co., Inc. | Protein delivery system using human papillomavirus virus-like particles |
| PL347472A1 (en) * | 1998-08-14 | 2002-04-08 | Merck & Co Inc | Process for purifying human papillomavirus virus-like particles |
| ATE344052T1 (de) * | 1998-08-14 | 2006-11-15 | Merck & Co Inc | Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt. |
| DE69924007T2 (de) * | 1998-12-23 | 2006-04-06 | Merck & Co., Inc. | Neutralsierungs-assay, das humane papillomavirus-ähnliche partikel verwendet |
| WO2001014416A2 (en) | 1999-08-25 | 2001-03-01 | Merck & Co., Inc. | Synthetic papillomavirus genes optimized for expression in human cells |
| US6436402B1 (en) * | 1999-10-15 | 2002-08-20 | Merck & Co., Inc. | Process for making human papillomavirus virus-like particles with improved properties |
| US7026443B1 (en) * | 1999-12-10 | 2006-04-11 | Epimmune Inc. | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| PT1301614E (pt) | 2000-07-21 | 2007-02-28 | Group Limited Glaxo | Sequências de codão optimizado do vírus do papiloma |
| WO2003068163A2 (en) * | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Optimization of gene sequences of chimeric virus-like particles for expression in insect cells |
| GB0206360D0 (en) | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| CA2519112C (en) | 2003-03-24 | 2012-09-11 | Merck & Co., Inc. | Optimized expression of hpv 31 l1 in yeast |
-
2004
- 2004-09-21 MY MYPI20043867A patent/MY140664A/en unknown
- 2004-09-22 AR ARP040103420A patent/AR045804A1/es active IP Right Grant
- 2004-09-23 TW TW093128883A patent/TWI350853B/zh not_active IP Right Cessation
- 2004-09-24 MX MXPA06003457A patent/MXPA06003457A/es active IP Right Grant
- 2004-09-24 RU RU2006114701/13A patent/RU2360001C2/ru active
- 2004-09-24 JP JP2006528190A patent/JP5451960B2/ja not_active Expired - Lifetime
- 2004-09-24 AU AU2004277934A patent/AU2004277934B2/en active Active
- 2004-09-24 BR BRPI0414845A patent/BRPI0414845B8/pt not_active IP Right Cessation
- 2004-09-24 KR KR1020067006044A patent/KR101165278B1/ko not_active Expired - Lifetime
- 2004-09-24 WO PCT/US2004/031326 patent/WO2005032586A1/en not_active Ceased
- 2004-09-24 DE DE602004021828T patent/DE602004021828D1/de not_active Expired - Lifetime
- 2004-09-24 DK DK04788982T patent/DK1673106T3/da active
- 2004-09-24 SI SI200431180T patent/SI1673106T1/sl unknown
- 2004-09-24 AT AT04788982T patent/ATE435029T1/de active
- 2004-09-24 CN CN2004800281067A patent/CN1859923B/zh not_active Expired - Lifetime
- 2004-09-24 ES ES04788982T patent/ES2327530T3/es not_active Expired - Lifetime
- 2004-09-24 NZ NZ545834A patent/NZ545834A/en not_active IP Right Cessation
- 2004-09-24 CA CA2539168A patent/CA2539168C/en not_active Expired - Lifetime
- 2004-09-24 US US10/573,330 patent/US7250170B2/en not_active Expired - Lifetime
- 2004-09-24 PT PT04788982T patent/PT1673106E/pt unknown
- 2004-09-24 PL PL04788982T patent/PL1673106T3/pl unknown
- 2004-09-24 EP EP04788982A patent/EP1673106B1/en not_active Expired - Lifetime
-
2006
- 2006-03-08 ZA ZA200601961A patent/ZA200601961B/en unknown
- 2006-03-20 IS IS8362A patent/IS2694B/is unknown
- 2006-03-21 IL IL174458A patent/IL174458A/en active IP Right Grant
- 2006-04-28 NO NO20061876A patent/NO339932B1/no active Protection Beyond IP Right Term
-
2007
- 2007-05-23 US US11/805,453 patent/US7482015B2/en not_active Expired - Lifetime
-
2009
- 2009-09-21 CY CY20091100973T patent/CY1110525T1/el unknown
-
2010
- 2010-07-07 AR ARP100102440A patent/AR077396A2/es not_active Application Discontinuation
-
2011
- 2011-03-02 JP JP2011045589A patent/JP2011152137A/ja active Pending
-
2014
- 2014-06-24 JP JP2014129350A patent/JP2014221052A/ja active Pending
-
2015
- 2015-11-30 NL NL300776C patent/NL300776I2/nl unknown
- 2015-12-02 HU HUS1500063C patent/HUS1500063I1/hu unknown
- 2015-12-04 FR FR15C0083C patent/FR15C0083I2/fr active Active
- 2015-12-07 CY CY2015050C patent/CY2015050I1/el unknown
- 2015-12-08 LT LTPA2015049C patent/LTC1673106I2/lt unknown
- 2015-12-08 LU LU92902C patent/LU92902I2/xx unknown
- 2015-12-08 LT LTPA2015049D patent/LTPA2015049I1/lt unknown
- 2015-12-09 BE BE2015C072C patent/BE2015C072I2/nl unknown
-
2016
- 2016-02-04 JP JP2016019712A patent/JP2016136947A/ja active Pending
-
2017
- 2017-04-05 NO NO2017012C patent/NO2017012I1/no unknown
-
2022
- 2022-11-30 NO NO2022051C patent/NO2022051I1/no unknown
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