JP2015521848A5 - - Google Patents
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- Publication number
- JP2015521848A5 JP2015521848A5 JP2015520569A JP2015520569A JP2015521848A5 JP 2015521848 A5 JP2015521848 A5 JP 2015521848A5 JP 2015520569 A JP2015520569 A JP 2015520569A JP 2015520569 A JP2015520569 A JP 2015520569A JP 2015521848 A5 JP2015521848 A5 JP 2015521848A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- protein
- seq
- nucleic acid
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 33
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 102100029199 Iduronate 2-sulfatase Human genes 0.000 claims 14
- 101710096421 Iduronate 2-sulfatase Proteins 0.000 claims 14
- 235000018102 proteins Nutrition 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- UGJBHEZMOKVTIM-UHFFFAOYSA-N N-formylglycine Chemical compound OC(=O)CNC=O UGJBHEZMOKVTIM-UHFFFAOYSA-N 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 238000004113 cell culture Methods 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 claims 6
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 6
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 5
- AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical compound OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 claims 5
- 102000005262 Sulfatase Human genes 0.000 claims 5
- 108060007951 sulfatase Proteins 0.000 claims 5
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000005096 rolling process Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261666719P | 2012-06-29 | 2012-06-29 | |
| US61/666,719 | 2012-06-29 | ||
| PCT/US2013/048571 WO2014005019A2 (en) | 2012-06-29 | 2013-06-28 | Cells for producing recombinant iduronate-2-sulfatase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016052380A Division JP6302499B2 (ja) | 2012-06-29 | 2016-03-16 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015521848A JP2015521848A (ja) | 2015-08-03 |
| JP2015521848A5 true JP2015521848A5 (enExample) | 2016-01-07 |
| JP6067849B2 JP6067849B2 (ja) | 2017-01-25 |
Family
ID=49778522
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520569A Active JP6067849B2 (ja) | 2012-06-29 | 2013-06-28 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
| JP2016052380A Active JP6302499B2 (ja) | 2012-06-29 | 2016-03-16 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
| JP2018037376A Active JP6755272B2 (ja) | 2012-06-29 | 2018-03-02 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016052380A Active JP6302499B2 (ja) | 2012-06-29 | 2016-03-16 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
| JP2018037376A Active JP6755272B2 (ja) | 2012-06-29 | 2018-03-02 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US9150841B2 (enExample) |
| EP (1) | EP2874649B1 (enExample) |
| JP (3) | JP6067849B2 (enExample) |
| KR (1) | KR101710487B1 (enExample) |
| CN (2) | CN107267460A (enExample) |
| AU (3) | AU2013282400B2 (enExample) |
| BR (1) | BR112014032560B1 (enExample) |
| CA (1) | CA2877521C (enExample) |
| CL (1) | CL2014003568A1 (enExample) |
| CO (1) | CO7240394A2 (enExample) |
| CR (1) | CR20140586A (enExample) |
| DO (1) | DOP2014000298A (enExample) |
| EA (2) | EA202090805A1 (enExample) |
| ES (1) | ES2718346T3 (enExample) |
| GT (1) | GT201400302A (enExample) |
| HK (1) | HK1209331A1 (enExample) |
| IL (3) | IL236343A (enExample) |
| MX (2) | MX336716B (enExample) |
| MY (2) | MY157086A (enExample) |
| NZ (2) | NZ703137A (enExample) |
| PE (1) | PE20150957A1 (enExample) |
| PH (2) | PH12016500011B1 (enExample) |
| SG (2) | SG10201509397SA (enExample) |
| TR (1) | TR201904435T4 (enExample) |
| UA (1) | UA118955C2 (enExample) |
| WO (1) | WO2014005019A2 (enExample) |
| ZA (1) | ZA201409396B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US20160145589A1 (en) | 2011-06-24 | 2016-05-26 | Green Cross Corporation | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| EP2844737B1 (en) | 2012-05-02 | 2018-03-21 | Life Technologies Corporation | High yield transient expression in mammalian cells using unique pairing of high density growth and transfection medium and expression enhancers |
| KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
| US9150841B2 (en) * | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
| US20140004097A1 (en) * | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
| EP2885419A4 (en) | 2012-08-14 | 2016-05-25 | Moderna Therapeutics Inc | ENZYMES AND POLYMERASES FOR RNA SYNTHESIS |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| US9550972B2 (en) | 2014-09-29 | 2017-01-24 | General Electric Company | Devices, systems and methods for automated cell culturing |
| EP3101125A1 (en) * | 2015-06-05 | 2016-12-07 | Laboratorios Del Dr. Esteve, S.A. | Adenoassociated virus vectors for the treatment of mucopolysaccharidoses |
| CA3001003A1 (en) | 2015-10-05 | 2017-04-13 | Modernatx, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| BR112020005271A2 (pt) | 2017-10-02 | 2020-09-15 | Denali Therapeutics Inc. | proteína, polipeptídeo, polinucleotídeo, vetor, célula hospedeira, método para produção de um polipeptídeo, métodos de tratamento de um distúrbio, de diminuição do acúmulo, de monitoramento, de transporte de um agente e de tratamento de um lsd e composição farmacêutica |
| JP7060235B2 (ja) * | 2018-05-18 | 2022-04-26 | 国立大学法人広島大学 | 変異型イズロン酸－２－スルファターゼの機能回復薬剤のスクリーニング方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| US5310646A (en) | 1988-05-13 | 1994-05-10 | Regents Of The University Of Minnesota | Method for the detection of mucopolysaccharide storage diseases |
| US5932211A (en) | 1991-11-12 | 1999-08-03 | Women's And Children's Hospital | Glycosylation variants of iduronate 2-sulfatase |
| CA2185324A1 (en) | 1994-03-16 | 1995-09-21 | Steven D. Rosen | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor |
| US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| DE19527054A1 (de) | 1995-07-26 | 1997-01-30 | Behringwerke Ag | Verfahren zur Charakterisierung der Glycosylierung von Glycoproteinen sowie zur in-vitro Bestimmung der Bioverfügbarkeit von Glycoproteinen |
| EP2243827B2 (en) | 1996-08-30 | 2017-11-22 | Life Technologies Corporation | Serum-free mammalian cell culture medium, and uses thereof |
| US7368531B2 (en) | 1997-03-07 | 2008-05-06 | Human Genome Sciences, Inc. | Human secreted proteins |
| US7083793B2 (en) | 1999-02-26 | 2006-08-01 | Millennium Pharmaceuticals, Inc. | Tango 243 polypeptides and uses thereof |
| EP1179000A4 (en) | 1999-02-26 | 2005-10-12 | Millennium Pharm Inc | DECISION PROTEINS AND THEIR USE |
| ATE348173T1 (de) | 1999-04-26 | 2007-01-15 | Genentech Inc | Zellenzuchtverfahren für glycoproteine |
| JP2002017376A (ja) | 1999-07-08 | 2002-01-22 | Herikkusu Kenkyusho:Kk | 分泌蛋白質、または膜蛋白質 |
| JP2003508088A (ja) | 1999-09-03 | 2003-03-04 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ５２個のヒト分泌タンパク質 |
| US6780627B1 (en) | 2000-01-31 | 2004-08-24 | Millennium Pharmaceuticals, Inc. | 22438, 23553, 25278, and 26212 novel human sulfatases |
| JP2004502404A (ja) | 2000-02-17 | 2004-01-29 | インサイト・ゲノミックス・インコーポレイテッド | ヒトキナーゼ |
| CA2400638A1 (en) | 2000-03-17 | 2001-09-27 | Human Genome Sciences, Inc. | 7 human ovarian and ovarian cancer associated proteins |
| CA2405550A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20030148920A1 (en) | 2000-12-27 | 2003-08-07 | Steven Rosen | Sulfatases and methods of use thereof |
| AU2002317700A1 (en) | 2001-06-07 | 2002-12-16 | Hemebiotech A/S | Production of recombinant human arylsulfatase a |
| JP4319979B2 (ja) | 2002-04-26 | 2009-08-26 | ジェネンテック・インコーポレーテッド | タンパク質の非アフィニティ精製 |
| US6890736B1 (en) | 2002-09-20 | 2005-05-10 | Immunex Corporation | Methods for producing proteins in cultured cells |
| BR0317723A (pt) | 2002-12-23 | 2005-11-22 | Bristol Myers Squibb Co | Processo de cultura de células de mamìfero para a produção de proteìna |
| US8227212B2 (en) | 2003-02-11 | 2012-07-24 | Shire Human Genetic Therapies, Inc. | Cell that expresses a sulfatase and a formylglycine generating enzyme |
| US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| WO2005113765A2 (en) | 2004-05-06 | 2005-12-01 | Biomarin Pharmaceutical Inc. | Methods of activation of sulfatases and methods and compositions of using the same |
| PL2267024T3 (pl) | 2005-06-03 | 2012-10-31 | Ares Trading Sa | Wytwarzanie rekombinowanego białka wiążącego IL-18 |
| WO2007108955A1 (en) | 2006-03-20 | 2007-09-27 | Medarex, Inc. | Protein purification |
| KR101744142B1 (ko) * | 2008-01-18 | 2017-06-07 | 바이오마린 파머수티컬 인크. | 활성이고 높은 정도로 인산화된 인간 리소좀 술파타아제 효소의 제조 및 그 용도 |
| BR112012007913A2 (pt) * | 2009-10-09 | 2019-09-24 | Dow Global Technologies Llc | reator adiabático de fluxo pistonado, processo para produzir um prpeno clorado ou fluorado, processo para preparar um produto a jusante e processo para preparar 2,3,3,3-tetrafluoroprop-1-eno (hfo-123yf) ou 1,3,3,3-tetrafluoroprop-1-eno (hfo-123ze) |
| HUE044865T2 (hu) | 2009-10-09 | 2019-11-28 | Armagen Inc | Eljárások és készítmények a központi idegrendszerben iduronát-2-szulfatáz-aktivitás növelésére |
| JPWO2011108451A1 (ja) | 2010-03-01 | 2013-06-27 | 日本ケミカルリサーチ株式会社 | 遺伝子ノックアウト細胞を用いた組換え体リソソーム酵素の製造方法 |
| HRP20191924T1 (hr) | 2010-06-25 | 2020-01-10 | Shire Human Genetic Therapies, Inc. | Postupci i sastavi za isporuku iduronat-2-sulfataze u cns |
| WO2012101671A1 (en) | 2011-01-25 | 2012-08-02 | Jcr Pharmaceuticals Co., Ltd. | Method for production of human recombinant iduronate 2-sulfatase |
| KR101158673B1 (ko) | 2011-06-24 | 2012-07-03 | 주식회사 지씨바이오 | 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법 |
| US20140004097A1 (en) | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
| US9150841B2 (en) | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
| KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
-
2013
- 2013-03-14 US US13/829,780 patent/US9150841B2/en active Active
- 2013-06-28 ES ES13810018T patent/ES2718346T3/es active Active
- 2013-06-28 MY MYPI2014003485A patent/MY157086A/en unknown
- 2013-06-28 PE PE2014002538A patent/PE20150957A1/es not_active Application Discontinuation
- 2013-06-28 CN CN201710300757.6A patent/CN107267460A/zh active Pending
- 2013-06-28 TR TR2019/04435T patent/TR201904435T4/tr unknown
- 2013-06-28 NZ NZ703137A patent/NZ703137A/en unknown
- 2013-06-28 CN CN201380037937.XA patent/CN104540517A/zh active Pending
- 2013-06-28 SG SG10201509397SA patent/SG10201509397SA/en unknown
- 2013-06-28 PH PH1/2016/500011A patent/PH12016500011B1/en unknown
- 2013-06-28 NZ NZ734670A patent/NZ734670A/en unknown
- 2013-06-28 EA EA202090805A patent/EA202090805A1/ru unknown
- 2013-06-28 WO PCT/US2013/048571 patent/WO2014005019A2/en not_active Ceased
- 2013-06-28 JP JP2015520569A patent/JP6067849B2/ja active Active
- 2013-06-28 SG SG11201408702VA patent/SG11201408702VA/en unknown
- 2013-06-28 MX MX2015000189A patent/MX336716B/es unknown
- 2013-06-28 MY MYPI2016000156A patent/MY189314A/en unknown
- 2013-06-28 EP EP13810018.5A patent/EP2874649B1/en active Active
- 2013-06-28 BR BR112014032560-0A patent/BR112014032560B1/pt active IP Right Grant
- 2013-06-28 MX MX2016001229A patent/MX366155B/es unknown
- 2013-06-28 UA UAA201413829A patent/UA118955C2/uk unknown
- 2013-06-28 AU AU2013282400A patent/AU2013282400B2/en active Active
- 2013-06-28 CA CA2877521A patent/CA2877521C/en active Active
- 2013-06-28 EA EA201492183A patent/EA035511B1/ru not_active IP Right Cessation
- 2013-06-28 KR KR1020157000841A patent/KR101710487B1/ko active Active
- 2013-06-28 HK HK15110031.3A patent/HK1209331A1/xx unknown
-
2014
- 2014-12-17 CR CR20140586A patent/CR20140586A/es unknown
- 2014-12-18 IL IL236343A patent/IL236343A/en active IP Right Grant
- 2014-12-19 ZA ZA2014/09396A patent/ZA201409396B/en unknown
- 2014-12-22 DO DO2014000298A patent/DOP2014000298A/es unknown
- 2014-12-22 PH PH12014502868A patent/PH12014502868B1/en unknown
- 2014-12-26 CO CO14284192A patent/CO7240394A2/es unknown
- 2014-12-29 CL CL2014003568A patent/CL2014003568A1/es unknown
- 2014-12-29 GT GT201400302A patent/GT201400302A/es unknown
-
2015
- 2015-08-21 US US14/832,728 patent/US9719074B2/en active Active
-
2016
- 2016-01-27 AU AU2016200460A patent/AU2016200460B2/en active Active
- 2016-03-16 JP JP2016052380A patent/JP6302499B2/ja active Active
-
2017
- 2017-07-14 US US15/650,536 patent/US20180010108A1/en not_active Abandoned
- 2017-09-18 IL IL254560A patent/IL254560B/en active IP Right Grant
-
2018
- 2018-01-30 AU AU2018200710A patent/AU2018200710B2/en active Active
- 2018-03-02 JP JP2018037376A patent/JP6755272B2/ja active Active
-
2020
- 2020-04-27 IL IL274266A patent/IL274266B/en active IP Right Grant
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