ATE348173T1 - Zellenzuchtverfahren für glycoproteine - Google Patents
Zellenzuchtverfahren für glycoproteineInfo
- Publication number
- ATE348173T1 ATE348173T1 AT00926245T AT00926245T ATE348173T1 AT E348173 T1 ATE348173 T1 AT E348173T1 AT 00926245 T AT00926245 T AT 00926245T AT 00926245 T AT00926245 T AT 00926245T AT E348173 T1 ATE348173 T1 AT E348173T1
- Authority
- AT
- Austria
- Prior art keywords
- glycoprotein
- glycoproteins
- culturing
- cultivation method
- cell
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 title abstract 4
- 108090000288 Glycoproteins Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000004113 cell culture Methods 0.000 title abstract 2
- 238000012258 culturing Methods 0.000 abstract 2
- 229940123587 Cell cycle inhibitor Drugs 0.000 abstract 1
- 230000004988 N-glycosylation Effects 0.000 abstract 1
- 150000004648 butanoic acid derivatives Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13107699P | 1999-04-26 | 1999-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE348173T1 true ATE348173T1 (de) | 2007-01-15 |
Family
ID=22447757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00926245T ATE348173T1 (de) | 1999-04-26 | 2000-04-21 | Zellenzuchtverfahren für glycoproteine |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6506598B1 (de) |
| EP (1) | EP1171615B1 (de) |
| JP (1) | JP4543131B2 (de) |
| AT (1) | ATE348173T1 (de) |
| AU (2) | AU778046B2 (de) |
| CA (1) | CA2368797C (de) |
| CY (1) | CY1107338T1 (de) |
| DE (1) | DE60032349T2 (de) |
| DK (1) | DK1171615T3 (de) |
| ES (1) | ES2281342T3 (de) |
| IL (2) | IL145893A0 (de) |
| PT (1) | PT1171615E (de) |
| WO (1) | WO2000065070A2 (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9828624D0 (en) * | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Production of proteins |
| US20050164386A1 (en) * | 1999-04-15 | 2005-07-28 | Uytdehaag Alphonsus G. | Overexpression of enzymes involved in post-translational protein modifications in human cells |
| US7297680B2 (en) * | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
| EP1757700A3 (de) * | 1999-04-26 | 2009-03-11 | Genentech, Inc. | Zellenzuchtverfahren für Glycoproteine |
| US7521220B2 (en) * | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
| US7192759B1 (en) * | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
| IL136232A0 (en) * | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
| US20030040095A1 (en) * | 2001-03-16 | 2003-02-27 | Achille Arini | Method for the production of pharmaceutically active recombinant proteins |
| EP1373547A4 (de) * | 2001-03-27 | 2006-01-18 | Smithkline Beecham Corp | Kontrolle von glycoformen in igg |
| MEP38608A (en) * | 2001-10-22 | 2011-02-10 | Merck Serono Sa | Gonadotrophins for folliculogenesis |
| JP4192097B2 (ja) * | 2001-10-25 | 2008-12-03 | バル−イラン ユニバーシティ | 相互作用型透明個別細胞バイオチッププロセッサー |
| JP2005521401A (ja) * | 2002-03-27 | 2005-07-21 | イミュネックス・コーポレーション | ポリペプチド産生を増加させる方法 |
| TWI312368B (en) * | 2002-12-23 | 2009-07-21 | Bristol Myers Squibb Compan | Mammalian cell culture processes for protein production |
| SI1576182T2 (sl) | 2002-12-23 | 2020-07-31 | Bristol-Myers Squibb Company | Izboljšava kvalitete izdelka v procesih pridelave beljakovin v celični kulturi sesalcev |
| IL154677A0 (en) * | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
| CA2522779A1 (en) * | 2003-04-25 | 2004-11-11 | Immunex Corporation | Inducers of recombinant protein expression |
| CA2520891C (en) | 2003-05-09 | 2014-07-08 | Crucell Holland B.V. | Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom |
| US8597597B2 (en) * | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
| US7888110B2 (en) * | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
| US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
| EP1654347B1 (de) * | 2003-06-26 | 2014-06-04 | Seng Enterprises Limited | Verbesserte Materialien zur Konstruktion von Zellchips, Zellchip-Abdeckungen, Zellchip-Hüllen, prozessierte Zellchips und Verwendungen davon |
| WO2005008626A1 (en) * | 2003-07-11 | 2005-01-27 | University Of North Carolina At Chapel Hill | Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop |
| US20050064524A1 (en) * | 2003-08-11 | 2005-03-24 | Mordechai Deutsch | Population of cells utilizable for substance detection and methods and devices using same |
| JP2007520546A (ja) * | 2004-02-03 | 2007-07-26 | ケマジス リミティド | モンテルカストナトリウムの安定な非晶質性形態 |
| US7361493B1 (en) | 2004-05-26 | 2008-04-22 | The United States Of America As Represented By The Secretary Of The Department Of Veterans Affairs | Production of urokinase in a three-dimensional cell culture |
| US20080063251A1 (en) * | 2004-07-07 | 2008-03-13 | Mordechai Deutsch | Method and Device for Identifying an Image of a Well in an Image of a Well-Bearing |
| US7403647B2 (en) * | 2004-09-13 | 2008-07-22 | Seng Enterprises Ltd. | Method for identifying an image of a well in an image of a well-bearing component |
| US20080009051A1 (en) * | 2004-08-25 | 2008-01-10 | Seng Enterprises Ltd. | Method and Device for Isolating Cells |
| DE602005023534D1 (de) | 2005-01-25 | 2010-10-21 | Seng Entpr Ltd | Mikrofluidische vorrichtung zur untersuchung zellen |
| DE102005034043B4 (de) * | 2005-07-18 | 2019-12-12 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch |
| US20070141555A1 (en) * | 2005-10-11 | 2007-06-21 | Mordechai Deutsch | Current damper for the study of cells |
| US8288120B2 (en) * | 2005-11-03 | 2012-10-16 | Seng Enterprises Ltd. | Method for studying floating, living cells |
| WO2007070315A2 (en) * | 2005-12-08 | 2007-06-21 | Amgen Inc. | Improved production of glycoproteins using manganese |
| AU2006322028C1 (en) | 2005-12-08 | 2025-09-04 | Amgen Inc. | Improved host cells and culture methods |
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| JP5096369B2 (ja) | 2005-12-20 | 2012-12-12 | ブリストル−マイヤーズ スクイブ カンパニー | 組成物および組成物の製造方法 |
| US20060223999A1 (en) * | 2006-05-10 | 2006-10-05 | Chemagis Ltd. | Process for preparing montelukast and precursors thereof |
| AU2016244316B2 (en) * | 2006-07-13 | 2018-07-12 | Wyeth Llc | Production of glycoproteins |
| CN101541950A (zh) * | 2006-07-13 | 2009-09-23 | 惠氏公司 | 糖蛋白的产生 |
| EP2135081B1 (de) * | 2007-04-16 | 2012-12-05 | Momenta Pharmaceuticals, Inc. | Verfahren in zusammenhang mit oberflächenglycosylierung |
| BRPI0810471A2 (pt) * | 2007-04-16 | 2014-11-11 | Momenta Pharmaceuticals Inc | Produtos de glicoproteína definidos e métodos relacionados |
| US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
| EP2237887A2 (de) | 2007-12-26 | 2010-10-13 | Seng Enterprises Ltd. | Vorrichtung zur untersuchung von lebenden zellen |
| SI2464725T2 (sl) | 2009-08-11 | 2025-06-30 | F. Hoffmann-La Roche Ag | Proizvodnja beljakovin v medijih za celične kulture brez glutamina |
| WO2011019622A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Cell culture methods to make antibodies with enhanced adcc function |
| US9540426B2 (en) | 2009-10-06 | 2017-01-10 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
| BR112012025645A2 (pt) | 2010-04-07 | 2017-12-12 | Momenta Pharmaceuticals Inc | glicanos de alta manose. |
| US9170249B2 (en) | 2011-03-12 | 2015-10-27 | Momenta Pharmaceuticals, Inc. | N-acetylhexosamine-containing N-glycans in glycoprotein products |
| EP2702077A2 (de) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Verfahren zur steuerung des galactosylierungsprofil von rekombinant exprimierten proteinen |
| US20160145589A1 (en) | 2011-06-24 | 2016-05-26 | Green Cross Corporation | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| WO2013181575A2 (en) | 2012-06-01 | 2013-12-05 | Momenta Pharmaceuticals, Inc. | Methods related to denosumab |
| US20140004097A1 (en) * | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
| US9150841B2 (en) | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
| KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| JP2015531244A (ja) | 2012-10-15 | 2015-11-02 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | タンパク質を製造するための哺乳動物細胞培養方法 |
| EP2830651A4 (de) | 2013-03-12 | 2015-09-02 | Abbvie Inc | An humanes tnf-alpha bindende humane antikörper und verfahren zur herstellung davon |
| US9677105B2 (en) | 2013-03-14 | 2017-06-13 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US8956830B2 (en) | 2013-03-14 | 2015-02-17 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US10450361B2 (en) | 2013-03-15 | 2019-10-22 | Momenta Pharmaceuticals, Inc. | Methods related to CTLA4-Fc fusion proteins |
| ES2708759T3 (es) | 2013-05-13 | 2019-04-11 | Momenta Pharmaceuticals Inc | Procedimientos para el tratamiento de la neurodegeneración |
| KR20150026024A (ko) * | 2013-08-30 | 2015-03-11 | 한미약품 주식회사 | 인간 혈액응고 7인자 유도체의 대량 생산 방법 |
| EP3052640A2 (de) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Verwendung von metallionen zur modulation von proteinglykosylierungsprofilen rekombinanter proteine |
| EP3058084A4 (de) | 2013-10-16 | 2017-07-05 | Momenta Pharmaceuticals, Inc. | Sialylierte glycoproteine |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| LT3209767T (lt) * | 2014-10-21 | 2020-11-25 | Gennova Biopharmaceuticals Ltd. | Naujas gryninimo būdas, skirtas rekombinantinės tnk-tpa (tenekteplazės) išskyrimui ir pramoninei gamybai |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8003402A (nl) | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
| US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| AU605124B2 (en) | 1985-12-23 | 1991-01-10 | Behringwerke Aktiengesellschaft | Novel peptide plasminogen activators |
| IE81073B1 (en) | 1986-03-18 | 2000-01-12 | Genentech Inc | Modified human tissue-type plasminogen activator and its preparation |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| NL8700385A (nl) * | 1987-02-16 | 1988-09-16 | Tno | Het gebruik van butyraat en andere laag-molekulaire vetzuren met betrekking tot verhoging van produktie van weefsel-type plasminogeen aktivator. |
| EP0435911B1 (de) | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
| US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
-
2000
- 2000-04-21 EP EP00926245A patent/EP1171615B1/de not_active Expired - Lifetime
- 2000-04-21 PT PT00926245T patent/PT1171615E/pt unknown
- 2000-04-21 DK DK00926245T patent/DK1171615T3/da active
- 2000-04-21 US US09/553,924 patent/US6506598B1/en not_active Expired - Lifetime
- 2000-04-21 AT AT00926245T patent/ATE348173T1/de active
- 2000-04-21 WO PCT/US2000/010810 patent/WO2000065070A2/en not_active Ceased
- 2000-04-21 ES ES00926245T patent/ES2281342T3/es not_active Expired - Lifetime
- 2000-04-21 DE DE60032349T patent/DE60032349T2/de not_active Expired - Lifetime
- 2000-04-21 AU AU44806/00A patent/AU778046B2/en not_active Expired
- 2000-04-21 JP JP2000614404A patent/JP4543131B2/ja not_active Expired - Lifetime
- 2000-04-21 CA CA2368797A patent/CA2368797C/en not_active Expired - Lifetime
- 2000-04-21 IL IL14589300A patent/IL145893A0/xx unknown
- 2000-11-27 US US09/723,545 patent/US6610516B1/en not_active Expired - Lifetime
-
2001
- 2001-10-11 IL IL145893A patent/IL145893A/en not_active IP Right Cessation
-
2005
- 2005-02-11 AU AU2005200622A patent/AU2005200622B2/en not_active Expired
-
2007
- 2007-02-20 CY CY20071100236T patent/CY1107338T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1171615E (pt) | 2007-03-30 |
| CA2368797A1 (en) | 2000-11-02 |
| WO2000065070A2 (en) | 2000-11-02 |
| AU2005200622A1 (en) | 2005-03-10 |
| DE60032349T2 (de) | 2007-07-12 |
| AU2005200622B2 (en) | 2007-08-23 |
| JP2002542787A (ja) | 2002-12-17 |
| CA2368797C (en) | 2010-08-17 |
| JP4543131B2 (ja) | 2010-09-15 |
| EP1171615B1 (de) | 2006-12-13 |
| WO2000065070A3 (en) | 2001-07-12 |
| DE60032349D1 (de) | 2007-01-25 |
| EP1171615A2 (de) | 2002-01-16 |
| CY1107338T1 (el) | 2012-12-19 |
| WO2000065070A9 (en) | 2001-08-02 |
| ES2281342T3 (es) | 2007-10-01 |
| AU4480600A (en) | 2000-11-10 |
| US6506598B1 (en) | 2003-01-14 |
| US6610516B1 (en) | 2003-08-26 |
| AU778046B2 (en) | 2004-11-11 |
| IL145893A0 (en) | 2002-07-25 |
| IL145893A (en) | 2009-11-18 |
| DK1171615T3 (da) | 2007-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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