BRPI0506610A - montelucaste sódico amorfo, processo de preparação de montelucaste sódico amorfo, composição farmacêutica, método de tratamento utilizando a administração de montelucaste sódico amorfo, co-precipitado amorfo de montelucaste sódico e processo de preparação de co-precipitado amorfo de montelucaste sódico - Google Patents

montelucaste sódico amorfo, processo de preparação de montelucaste sódico amorfo, composição farmacêutica, método de tratamento utilizando a administração de montelucaste sódico amorfo, co-precipitado amorfo de montelucaste sódico e processo de preparação de co-precipitado amorfo de montelucaste sódico

Info

Publication number
BRPI0506610A
BRPI0506610A BRPI0506610-7A BRPI0506610A BRPI0506610A BR PI0506610 A BRPI0506610 A BR PI0506610A BR PI0506610 A BRPI0506610 A BR PI0506610A BR PI0506610 A BRPI0506610 A BR PI0506610A
Authority
BR
Brazil
Prior art keywords
amorphous
montelukast
sodium
preparation process
precipitate
Prior art date
Application number
BRPI0506610-7A
Other languages
English (en)
Inventor
Itain Adin
Mohamed Alnabari
Yana Sery
Oded Arad
Joseph Kaspi
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Publication of BRPI0506610A publication Critical patent/BRPI0506610A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

MONTELUCASTE SóDIO AMORFO, PROCESSO DE PREPARAçãO DE MONTELUCASTE SóDICO AMORFO, COMPOSIçãO FARMACêUTICA, MéTODO DE TRATAMENTO UTILIZANDO A ADMINISTRAçãO DE MONTELUCASTE SóDICO AMORFO, CO-PRECIPITADO AMORFO DE MONTELUCASTE SóDICO E PROCESSO DE PREPARAçãO DE CO-PRECIPITADO AMORFO DE MONTELUCASTE SóDICO, revela uma forma amorfa a montelucaste sódico e co-precipitado de lactose de montelucaste sódico, processos para produção do mesmo, composições farmacêuticas contendo o mesmo e métodos de tratamento utilizando os mesmos.
BRPI0506610-7A 2004-02-03 2005-02-03 montelucaste sódico amorfo, processo de preparação de montelucaste sódico amorfo, composição farmacêutica, método de tratamento utilizando a administração de montelucaste sódico amorfo, co-precipitado amorfo de montelucaste sódico e processo de preparação de co-precipitado amorfo de montelucaste sódico BRPI0506610A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54105204P 2004-02-03 2004-02-03
PCT/IL2005/000134 WO2005074893A1 (en) 2004-02-03 2005-02-03 Stable amorphous forms of montelukast sodium

Publications (1)

Publication Number Publication Date
BRPI0506610A true BRPI0506610A (pt) 2007-05-02

Family

ID=34837451

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506610-7A BRPI0506610A (pt) 2004-02-03 2005-02-03 montelucaste sódico amorfo, processo de preparação de montelucaste sódico amorfo, composição farmacêutica, método de tratamento utilizando a administração de montelucaste sódico amorfo, co-precipitado amorfo de montelucaste sódico e processo de preparação de co-precipitado amorfo de montelucaste sódico

Country Status (8)

Country Link
US (1) US7544805B2 (pt)
EP (1) EP1711166A1 (pt)
JP (1) JP2007520546A (pt)
AU (1) AU2005210236B2 (pt)
BR (1) BRPI0506610A (pt)
CA (1) CA2554927A1 (pt)
NZ (1) NZ548873A (pt)
WO (1) WO2005074893A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544805B2 (en) 2004-02-03 2009-06-09 Chemagis Ltd. Stable amorphous forms of montelukast sodium
DE602005015174D1 (de) 2004-04-21 2009-08-13 Teva Pharma Verfahren zur herstellung von montelukast-natrium
AU2005237523A1 (en) 2004-04-23 2005-11-10 Cydex Pharmaceuticals, Inc. DPI formulation containing sulfoalkyl ether cyclodextrin
EP1831171A4 (en) * 2004-11-19 2010-09-15 Matrix Lab Ltd PROCESS FOR THE PREPARATION OF NEW MONTELUKAST SODIUM AMORPHOUS
CA2608369A1 (en) 2005-07-05 2007-01-11 Teva Pharmaceutical Industries Ltd. Purification of montelukast
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
CA2625285A1 (en) * 2005-11-16 2007-05-24 Teva Pharmaceutical Industries Ltd. Drying methods of montelukast sodium by azeotropic removal of the solvent
ES2426443T3 (es) 2005-12-30 2013-10-23 Krka Tovarna Zdravil, D.D., Novo Mesto Composición farmacéutica que contiene montelukast
AU2006337648A1 (en) * 2006-02-09 2007-08-16 Teva Pharmaceutical Industries Ltd. Stable pharmaceutical formulations of montelukast sodium
EP2004608B1 (en) 2006-04-12 2011-09-14 Glade Organics Private Limited An improved process for the manufacture of montelukast sodium
EP1886997A1 (en) * 2006-08-09 2008-02-13 Esteve Quimica, S.A. Process for the purification of montelukast
EP2287154A1 (en) 2009-07-14 2011-02-23 KRKA, D.D., Novo Mesto Efficient synthesis for the preparation of montelukast
WO2011033470A1 (en) 2009-09-16 2011-03-24 Ranbaxy Laboratories Limited Crystalline form of montelukast sodium
HUE026633T2 (en) * 2010-02-26 2016-06-28 Toray Industries Covered solid preparation
WO2011121091A1 (en) 2010-03-31 2011-10-06 Krka, D.D., Novo Mesto Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
US8471030B2 (en) 2010-12-06 2013-06-25 Orochem Technologies Inc. Purification of montelukast using simulated moving bed
EP3134076A4 (en) 2014-04-25 2017-12-20 R.P. Scherer Technologies, LLC A stable montelukast solution
CN107162969A (zh) * 2017-07-05 2017-09-15 成都亿知科技有限公司 孟鲁司特钠晶体及其制备方法和药物组合物
WO2020049505A1 (en) 2018-09-06 2020-03-12 Innopharmascreen Inc. Methods and compositions for treatment of asthma or parkinson's disease

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US655365A (en) 1899-11-14 1900-08-07 Henry M Johnson Hernial truss.
US4308351A (en) * 1980-04-18 1981-12-29 Joseph Leighton System for growing tissue cultures
IL68507A (en) * 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
US5272081A (en) * 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
US5310674A (en) 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
US5681718A (en) * 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
JP2662215B2 (ja) * 1986-11-19 1997-10-08 株式会社日立製作所 細胞保持装置
GB2233928B (en) * 1989-05-23 1992-12-23 Brother Ind Ltd Apparatus and method for forming three-dimensional article
US5635386A (en) * 1989-06-15 1997-06-03 The Regents Of The University Of Michigan Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture
GB8927742D0 (en) * 1989-12-07 1990-02-07 Diatec A S Process and apparatus
US5204055A (en) * 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
DE69129257T2 (de) * 1990-10-12 1998-11-05 Merck Frosst Canada Inc Ungesättigte Hydroxyalkylchinolinsäuren als Leukotrien-Antagonisten
SE9101090D0 (sv) 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
GB9215834D0 (en) * 1992-07-24 1992-09-09 Celltech Ltd Cell culture
US5395588A (en) * 1992-12-14 1995-03-07 Becton Dickinson And Company Control of flow cytometer having vacuum fluidics
TW416948B (en) 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists
US6206672B1 (en) * 1994-03-31 2001-03-27 Edward P. Grenda Apparatus of fabricating 3 dimensional objects by means of electrophotography, ionography or a similar process
US5824536A (en) * 1994-08-23 1998-10-20 St. Jude Children's Research Hospital Influenza virus replicated in mammalian cell culture and vaccine production
US5627045A (en) * 1995-04-12 1997-05-06 Biolog, Inc. Multi-test format with gel-forming matrix for characterization of microorganisms
US6117612A (en) * 1995-04-24 2000-09-12 Regents Of The University Of Michigan Stereolithography resin for rapid prototyping of ceramics and metals
US5905031A (en) * 1995-05-18 1999-05-18 Coulter International Corp. Identification of blast cells in a leukocyte cell preparation
US5840565A (en) * 1995-08-22 1998-11-24 The Regents Of The University Of California Methods for enhancing the production of viral vaccines in PKR-deficient cell culture
US6043092A (en) * 1996-03-18 2000-03-28 University Of Pittsburgh Cell culture media for mammalian cells
US6103479A (en) * 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6046426A (en) * 1996-07-08 2000-04-04 Sandia Corporation Method and system for producing complex-shape objects
GB9620934D0 (en) 1996-10-08 1996-11-27 Molecular Drives Limited Multi-well containers
US5854684A (en) * 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
US6692961B1 (en) * 1996-10-11 2004-02-17 Invitrogen Corporation Defined systems for epithelial cell culture and use thereof
US5885840A (en) 1997-02-10 1999-03-23 Compucyte Corp. Multiple assays of cell specimens
US6627426B2 (en) * 1997-02-14 2003-09-30 Invitrogen Corporation Methods for reducing adventitious agents and toxins and cell culture reagents produced thereby
US6383810B2 (en) * 1997-02-14 2002-05-07 Invitrogen Corporation Dry powder cells and cell culture reagents and methods of production thereof
US5869673A (en) * 1997-02-28 1999-02-09 Merck & Co., Inc. Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde
US5952347A (en) * 1997-03-13 1999-09-14 Merck & Co., Inc. Quinoline leukotriene antagonists
KR100266448B1 (ko) * 1997-06-26 2000-09-15 박종헌 식물세포 배양 중의 온도변화에 의한 택솔의 대량생산 방법
US6066285A (en) * 1997-12-12 2000-05-23 University Of Florida Solid freeform fabrication using power deposition
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6224907B1 (en) * 1998-03-06 2001-05-01 Alza Corporation Anti-asthma therapy
ATE227338T1 (de) 1998-03-18 2002-11-15 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6378527B1 (en) * 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
US6528286B1 (en) * 1998-05-29 2003-03-04 Genentech, Inc. Mammalian cell culture process for producing glycoproteins
FR2779443B1 (fr) * 1998-06-08 2000-08-04 Claude Hanni Dispositif de culture de cellules organiques et d'etude de leur activite electrophysiologique et membrane utilisee dans un tel dispositif
AT407047B (de) * 1998-08-03 2000-11-27 Pfaller Walter Dr Zellkulturvorrichtung
KR100271208B1 (ko) * 1998-08-13 2000-12-01 윤덕용 선택적 용침공정을 이용한 쾌속조형방법및 쾌속조형장치
US6511430B1 (en) * 1998-08-19 2003-01-28 University Health Network Use of high frequency ultrasound imaging to detect and monitor the process of apoptosis in living tissues, ex-vivo tissues and cell-culture
US6342384B1 (en) * 1998-08-21 2002-01-29 The University Of Va Patent Foundation Production of adenoviral vectors using serum-free suspension cell culture in a hollow fiber system
DE29817223U1 (de) * 1998-09-24 1998-11-19 Marotzki, Stefan, Dr., 25436 Tornesch Vorrichtung zur Aufnahme einer Zellkultur
US6228437B1 (en) * 1998-12-24 2001-05-08 United Technologies Corporation Method for modifying the properties of a freeform fabricated part
US6492148B1 (en) * 1999-03-05 2002-12-10 Akzo Nobel Nv Genetically engineered cell culture adapted infectious bursal disease virus (IBDV) mutants
US6455310B1 (en) * 1999-03-23 2002-09-24 Biocrystal Ltd. Cell culture apparatus and method for culturing cells
US6410309B1 (en) * 1999-03-23 2002-06-25 Biocrystal Ltd Cell culture apparatus and methods of use
CA2368797C (en) * 1999-04-26 2010-08-17 Genentech, Inc. Cell culture process
US6338964B1 (en) * 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
WO2000073417A1 (en) * 1999-05-27 2000-12-07 The Research Foundation Of State University Of New York In vitro cell culture device including cartilage and methods of using the same
JP2001037472A (ja) * 1999-07-28 2001-02-13 Bio Quest:Kk 三次元細胞培養基材及びそれを用いた細胞培養方法
US6333192B1 (en) * 1999-08-09 2001-12-25 North Carolina State University Method of producing an undifferentiated avian cell culture using avian primordial germ cells
NZ529329A (en) * 1999-08-25 2005-06-24 Immunex Corp Compositions and methods for improved cell culture
WO2001035071A2 (en) 1999-11-10 2001-05-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US6649408B2 (en) * 2000-03-24 2003-11-18 George Mason University Microdroplet cell culture technique
IL136232A0 (en) * 2000-05-18 2001-05-20 Bar Ilan University Res Author Measurements of enzymatic activity in a single, individual cell in population
KR20010110945A (ko) * 2000-06-09 2001-12-15 김정용 음경 확대 방법
US6670184B2 (en) * 2000-06-23 2003-12-30 Basf Ag Method for producing a lipid emulsion for use in insect cell culture
AU2001294520A1 (en) * 2000-08-21 2002-03-04 Clonex Development, Inc. Methods and compositions for increasing protein yield from a cell culture
WO2002026114A2 (en) 2000-09-27 2002-04-04 Bitensky Mark W Cellular diagnostic arrays, methods of using and processes for producing same
US7211209B2 (en) * 2000-11-08 2007-05-01 Surface Logix, Inc. Method of making device for arraying biomolecules and for monitoring cell motility in real-time
US6588586B2 (en) * 2000-12-08 2003-07-08 Biocrystal Ltd Mailer for cell culture device
US6376148B1 (en) * 2001-01-17 2002-04-23 Nanotek Instruments, Inc. Layer manufacturing using electrostatic imaging and lamination
US6403369B1 (en) * 2001-01-19 2002-06-11 Gary W. Wood Cell culture vessel
US20020106715A1 (en) 2001-02-02 2002-08-08 Medisel Ltd System and method for collecting data from individual cells
US20020151562A1 (en) * 2001-02-05 2002-10-17 Seligman Morton J. Compositions and methods for treating allergic fungal sinusitis
US6645757B1 (en) * 2001-02-08 2003-11-11 Sandia Corporation Apparatus and method for transforming living cells
DE10119718A1 (de) * 2001-04-21 2002-10-31 Boehringer Ingelheim Pharma Verfahren zur kontinuierlichen Herstellung inhalierfähiger Arzneistoffe, Vorrichtung zur Durchführung des Verfahrens und nach diesem Verfahren hergestellter Arzneistoff
WO2002092778A2 (en) * 2001-05-17 2002-11-21 The Board Of Trustees Of The Leland Stanford Junior University Device and method for three-dimensional spatial localization and functional interconnection of different types of cells
KR20020088848A (ko) * 2001-05-21 2002-11-29 (주)코아바이오텍 세포배양관 및 이를 이용한 대량 세포배양기
WO2003008943A1 (en) * 2001-07-19 2003-01-30 Tufts University Optical array device and methods of use thereof for screening, analysis and manipulation of particles
US7285412B2 (en) 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
WO2003035824A1 (en) 2001-10-25 2003-05-01 Bar-Ilan University Interactive transparent individual cells biochip processor
WO2003056330A2 (de) 2001-12-31 2003-07-10 Institut für Physikalische Hochtechnologie e.V. Zellsortiersystem zur grössenabhängigen sortierung oder separation von in einer strömenden flüssigkeit suspendierten zellen
AU2003244451A1 (en) * 2002-02-04 2003-09-02 Glaxo Group Limited Amorphous fluticasone 2-furoate, pharmaceutical compositions thereof and its conversion to the crystalline unsolvated form
WO2003066598A1 (en) * 2002-02-07 2003-08-14 Dr. Reddy's Laboratories Ltd. Novel anhydrous amorphous forms of montelukast sodium salt
US20030189850A1 (en) * 2002-04-09 2003-10-09 Toyo Boseki Kabushiki Kaisha Cell array system
IL154677A0 (en) 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
JP2004344036A (ja) * 2003-05-21 2004-12-09 Fujitsu Ltd 物質導入装置及び物質導入システム
EP1631550B1 (en) * 2003-06-06 2012-01-11 Morepen Laboratories Ltd. An improved method for the preparation of montelukast acid sodium salt in amorphous form
WO2005007796A2 (en) 2003-07-21 2005-01-27 Molecular Cytomics Ltd. Improved multiwell plate
EP1654347B1 (en) 2003-06-26 2014-06-04 Seng Enterprises Limited Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof
US20050026882A1 (en) 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050064524A1 (en) * 2003-08-11 2005-03-24 Mordechai Deutsch Population of cells utilizable for substance detection and methods and devices using same
ES2371549T3 (es) * 2003-10-10 2012-01-05 Synthon B.V. Montelukast en estado sólido.
US7544805B2 (en) 2004-02-03 2009-06-09 Chemagis Ltd. Stable amorphous forms of montelukast sodium

Also Published As

Publication number Publication date
CA2554927A1 (en) 2005-08-18
AU2005210236A1 (en) 2005-08-18
JP2007520546A (ja) 2007-07-26
US20050187245A1 (en) 2005-08-25
NZ548873A (en) 2010-04-30
AU2005210236B2 (en) 2010-09-09
WO2005074893A1 (en) 2005-08-18
US7544805B2 (en) 2009-06-09
EP1711166A1 (en) 2006-10-18

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