AU2001294520A1 - Methods and compositions for increasing protein yield from a cell culture - Google Patents
Methods and compositions for increasing protein yield from a cell cultureInfo
- Publication number
- AU2001294520A1 AU2001294520A1 AU2001294520A AU9452001A AU2001294520A1 AU 2001294520 A1 AU2001294520 A1 AU 2001294520A1 AU 2001294520 A AU2001294520 A AU 2001294520A AU 9452001 A AU9452001 A AU 9452001A AU 2001294520 A1 AU2001294520 A1 AU 2001294520A1
- Authority
- AU
- Australia
- Prior art keywords
- compositions
- methods
- cell culture
- protein yield
- increasing protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
- C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22629000P | 2000-08-21 | 2000-08-21 | |
US60/226,290 | 2000-08-21 | ||
PCT/US2001/026157 WO2002016590A2 (en) | 2000-08-21 | 2001-08-21 | Methods and compositions for increasing protein yield from a cell culture |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001294520A1 true AU2001294520A1 (en) | 2002-03-04 |
Family
ID=22848318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001294520A Abandoned AU2001294520A1 (en) | 2000-08-21 | 2001-08-21 | Methods and compositions for increasing protein yield from a cell culture |
Country Status (3)
Country | Link |
---|---|
US (3) | US6635448B2 (en) |
AU (1) | AU2001294520A1 (en) |
WO (1) | WO2002016590A2 (en) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL136232A0 (en) * | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
US6635448B2 (en) * | 2000-08-21 | 2003-10-21 | Clonexdevelopment, Inc. | Methods and compositions for increasing protein yield from a cell culture |
IL154677A0 (en) * | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
US7611885B2 (en) | 2003-06-24 | 2009-11-03 | Engeneic Molecular Delivery Pty, Ltd. | Pharmaceutically compatible method for purifying intact bacterial minicells |
US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
US8597597B2 (en) | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
US7888110B2 (en) | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
WO2005008626A1 (en) * | 2003-07-11 | 2005-01-27 | University Of North Carolina At Chapel Hill | Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop |
US20050064524A1 (en) * | 2003-08-11 | 2005-03-24 | Mordechai Deutsch | Population of cells utilizable for substance detection and methods and devices using same |
PL1694361T3 (en) | 2003-12-09 | 2011-08-31 | Engeneic Molecular Delivery Pty Ltd | Targeted gene delivery to non-phagocytic mammalian cells via bacterially derived intact minicells |
US8772013B2 (en) * | 2004-02-02 | 2014-07-08 | Engeneic Molecular Delivery Pty Ltd | Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
SG135175A1 (en) | 2004-02-02 | 2007-09-28 | Engeneic Molecular Delivery Pty Ltd | Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
JP2007520546A (en) * | 2004-02-03 | 2007-07-26 | ケマジス リミティド | A stable amorphous form of Montelukast sodium |
US7403647B2 (en) * | 2004-09-13 | 2008-07-22 | Seng Enterprises Ltd. | Method for identifying an image of a well in an image of a well-bearing component |
WO2006003664A1 (en) * | 2004-07-07 | 2006-01-12 | Seng Enterprises Ltd. | Method and device for identifying an image of a well in an image of a well-bearing component |
US7608425B2 (en) | 2004-07-23 | 2009-10-27 | Immunomedics, Inc. | Methods for protein expression in mammalian cells in serum-free medium |
US7531327B2 (en) | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
US7537930B2 (en) | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
MX2007002294A (en) | 2004-08-26 | 2007-10-19 | Engeneic Molecular Delivery Pty Ltd | Delivering functional nucleic acids to mammalian cells via bacterially derived, intact minicells. |
US20060051861A1 (en) * | 2004-09-07 | 2006-03-09 | Clonex Development, Inc. | Cell lines for use in increasing protein yield from a cell culture |
WO2006080000A1 (en) | 2005-01-25 | 2006-08-03 | Seng Enterprises Ltd. | Device for the studying individual cells |
US20070092947A1 (en) * | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
WO2007052245A1 (en) | 2005-11-03 | 2007-05-10 | Seng Enterprises Ltd. | Method and device for studying floating, living cells |
US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
DK1994155T4 (en) | 2006-02-13 | 2022-07-25 | Daiichi Sankyo Co Ltd | POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES INVOLVED IN THE BONE MODELING PROCESS |
US20060223999A1 (en) * | 2006-05-10 | 2006-10-05 | Chemagis Ltd. | Process for preparing montelukast and precursors thereof |
EP2040725B1 (en) | 2006-06-23 | 2014-01-15 | EnGeneIC Molecular Delivery Pty Ltd. | Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
TW201516149A (en) | 2006-09-13 | 2015-05-01 | Abbvie Inc | Cell culture improvements |
WO2008137122A2 (en) * | 2007-05-04 | 2008-11-13 | Shiloh Laoratories, Inc. | Inducing premature senescence to stabilize stem cell feeder layer cells |
US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
EP2237887A2 (en) | 2007-12-26 | 2010-10-13 | Seng Enterprises Ltd. | Device for the study of living cells |
CN105111309A (en) | 2008-10-20 | 2015-12-02 | Abbvie公司 | Isolation and purification of antibodies using protein an appinity chromatography |
CN102257005A (en) | 2008-10-20 | 2011-11-23 | 雅培制药有限公司 | Viral inactivation during purification of antibodies |
US8962277B2 (en) | 2010-07-05 | 2015-02-24 | Univeristät für Bodenkultur Wien | Production cell line |
EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
WO2014012165A1 (en) | 2012-07-19 | 2014-01-23 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
AU2013309506A1 (en) | 2012-09-02 | 2015-03-12 | Abbvie Inc. | Methods to control protein heterogeneity |
SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US588981A (en) * | 1897-08-31 | Lace-fastener | ||
US5917122A (en) * | 1992-08-26 | 1999-06-29 | Byrne; Guerard | Tetracycline repressor-mediated binary regulation system for control of gene expression in transgenic mice |
US5888981A (en) * | 1993-06-14 | 1999-03-30 | Basf Aktiengesellschaft | Methods for regulating gene expression |
US5891718A (en) | 1996-03-27 | 1999-04-06 | Vical Incorporated | Tetracycline inducible/repressible systems |
US6274341B1 (en) * | 1997-10-09 | 2001-08-14 | James E. Bailey | Cytostatic process increases the productivity of cultured cells |
US6635448B2 (en) * | 2000-08-21 | 2003-10-21 | Clonexdevelopment, Inc. | Methods and compositions for increasing protein yield from a cell culture |
-
2001
- 2001-08-21 US US09/935,194 patent/US6635448B2/en not_active Expired - Lifetime
- 2001-08-21 WO PCT/US2001/026157 patent/WO2002016590A2/en active Application Filing
- 2001-08-21 AU AU2001294520A patent/AU2001294520A1/en not_active Abandoned
-
2003
- 2003-08-22 US US10/646,129 patent/US7384776B2/en not_active Expired - Fee Related
-
2008
- 2008-06-10 US US12/136,317 patent/US7851219B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20020160450A1 (en) | 2002-10-31 |
US6635448B2 (en) | 2003-10-21 |
US7384776B2 (en) | 2008-06-10 |
US20090142828A1 (en) | 2009-06-04 |
US20050074856A1 (en) | 2005-04-07 |
US7851219B2 (en) | 2010-12-14 |
WO2002016590A3 (en) | 2002-08-15 |
WO2002016590A2 (en) | 2002-02-28 |
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