DK1171615T3 - Celledyrkningsfremgangsmåde for glycoproteiner - Google Patents
Celledyrkningsfremgangsmåde for glycoproteinerInfo
- Publication number
- DK1171615T3 DK1171615T3 DK00926245T DK00926245T DK1171615T3 DK 1171615 T3 DK1171615 T3 DK 1171615T3 DK 00926245 T DK00926245 T DK 00926245T DK 00926245 T DK00926245 T DK 00926245T DK 1171615 T3 DK1171615 T3 DK 1171615T3
- Authority
- DK
- Denmark
- Prior art keywords
- glycoprotein
- cell culture
- glycoproteins
- culturing
- culture method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13107699P | 1999-04-26 | 1999-04-26 | |
PCT/US2000/010810 WO2000065070A2 (en) | 1999-04-26 | 2000-04-21 | Cell culture process for glycoproteins |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1171615T3 true DK1171615T3 (da) | 2007-03-19 |
Family
ID=22447757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00926245T DK1171615T3 (da) | 1999-04-26 | 2000-04-21 | Celledyrkningsfremgangsmåde for glycoproteiner |
Country Status (13)
Country | Link |
---|---|
US (2) | US6506598B1 (da) |
EP (1) | EP1171615B1 (da) |
JP (1) | JP4543131B2 (da) |
AT (1) | ATE348173T1 (da) |
AU (2) | AU778046B2 (da) |
CA (1) | CA2368797C (da) |
CY (1) | CY1107338T1 (da) |
DE (1) | DE60032349T2 (da) |
DK (1) | DK1171615T3 (da) |
ES (1) | ES2281342T3 (da) |
IL (2) | IL145893A0 (da) |
PT (1) | PT1171615E (da) |
WO (1) | WO2000065070A2 (da) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9828624D0 (en) * | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Production of proteins |
US20050164386A1 (en) * | 1999-04-15 | 2005-07-28 | Uytdehaag Alphonsus G. | Overexpression of enzymes involved in post-translational protein modifications in human cells |
US7297680B2 (en) * | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
EP1757700A3 (en) * | 1999-04-26 | 2009-03-11 | Genentech, Inc. | Cell culture process for glycoproteins |
US7521220B2 (en) * | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
US7192759B1 (en) * | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
IL136232A0 (en) * | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
US20030040095A1 (en) * | 2001-03-16 | 2003-02-27 | Achille Arini | Method for the production of pharmaceutically active recombinant proteins |
AU2002256005A1 (en) * | 2001-03-27 | 2002-10-08 | Smithkline Beecham Corporation | Control of glycoforms in igg |
DK1438336T3 (da) * | 2001-10-22 | 2006-10-02 | Applied Research Systems | Gonadotropiner til follikeldannelse |
JP4192097B2 (ja) * | 2001-10-25 | 2008-12-03 | バル−イラン ユニバーシティ | 相互作用型透明個別細胞バイオチッププロセッサー |
ES2557741T3 (es) * | 2002-03-27 | 2016-01-28 | Immunex Corporation | Procedimientos para incrementar la producción de polipéptidos |
AU2003303394B2 (en) | 2002-12-23 | 2009-02-19 | Bristol-Myers Squibb Company | Product quality enhancement in mammalian cell culture processes for protein production |
JP4541157B2 (ja) | 2002-12-23 | 2010-09-08 | ブリストル−マイヤーズ スクイブ カンパニー | タンパク質を製造するための哺乳類細胞培養法 |
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JP4865539B2 (ja) * | 2003-05-09 | 2012-02-01 | クルセル ホランド ベー ヴェー | E1不死化細胞の培養物及び該培養物を培養して該培養物から得られる産物の収量を増加させる方法 |
US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
US20060240548A1 (en) * | 2003-06-26 | 2006-10-26 | Mordechai Deutsch | Materials for constructing cell-chips, cell-chip covers, cell-chips coats, processed cell-chips and uses thereof |
US8597597B2 (en) * | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
US7888110B2 (en) * | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
WO2005008626A1 (en) * | 2003-07-11 | 2005-01-27 | University Of North Carolina At Chapel Hill | Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop |
US20050064524A1 (en) * | 2003-08-11 | 2005-03-24 | Mordechai Deutsch | Population of cells utilizable for substance detection and methods and devices using same |
CA2554927A1 (en) * | 2004-02-03 | 2005-08-18 | Chemagis Ltd. | Stable amorphous forms of montelukast sodium |
US7361493B1 (en) | 2004-05-26 | 2008-04-22 | The United States Of America As Represented By The Secretary Of The Department Of Veterans Affairs | Production of urokinase in a three-dimensional cell culture |
US7403647B2 (en) * | 2004-09-13 | 2008-07-22 | Seng Enterprises Ltd. | Method for identifying an image of a well in an image of a well-bearing component |
US20080063251A1 (en) * | 2004-07-07 | 2008-03-13 | Mordechai Deutsch | Method and Device for Identifying an Image of a Well in an Image of a Well-Bearing |
EP1781404A2 (en) * | 2004-08-25 | 2007-05-09 | Seng Enterprises Limited | Method and device for isolating cells |
WO2006080000A1 (en) * | 2005-01-25 | 2006-08-03 | Seng Enterprises Ltd. | Device for the studying individual cells |
DE102005034043B4 (de) * | 2005-07-18 | 2019-12-12 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch |
US20070141555A1 (en) * | 2005-10-11 | 2007-06-21 | Mordechai Deutsch | Current damper for the study of cells |
WO2007052245A1 (en) * | 2005-11-03 | 2007-05-10 | Seng Enterprises Ltd. | Method and device for studying floating, living cells |
CA2630782C (en) | 2005-12-08 | 2015-02-03 | Amgen Inc. | Improved host cells and culture methods |
EP2495308A1 (en) * | 2005-12-08 | 2012-09-05 | Amgen Inc. | Improved production of glycoproteins using manganese |
PE20080556A1 (es) | 2005-12-20 | 2008-06-13 | Bristol Myers Squibb Co | Composicion que comprende una poblacion aislada de moleculas ctla4-ig a partir de un medio de cultivo liquido y metodos para su obtencion |
AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
US20060223999A1 (en) * | 2006-05-10 | 2006-10-05 | Chemagis Ltd. | Process for preparing montelukast and precursors thereof |
ES2668212T3 (es) * | 2006-07-13 | 2018-05-17 | Wyeth Llc | Producción de factor de coagulación IX con patrón de glucosilación mejorado |
AU2016244316B2 (en) * | 2006-07-13 | 2018-07-12 | Wyeth Llc | Production of glycoproteins |
WO2008128228A1 (en) * | 2007-04-16 | 2008-10-23 | Momenta Pharmaceuticals, Inc. | Methods related to cell surface glycosylation |
JP2010524467A (ja) * | 2007-04-16 | 2010-07-22 | モメンタ ファーマシューティカルズ インコーポレイテッド | 規定の糖タンパク質産物および関連の方法 |
US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
EP2237887A2 (en) | 2007-12-26 | 2010-10-13 | Seng Enterprises Ltd. | Device for the study of living cells |
LT2464725T (lt) | 2009-08-11 | 2020-06-10 | F. Hoffmann-La Roche Ag | Baltymų gamyba ląstelių mitybinėje terpėje, kurioje nėra glutamino |
WO2011019622A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Cell culture methods to make antibodies with enhanced adcc function |
US9540426B2 (en) | 2009-10-06 | 2017-01-10 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
MX2012011648A (es) | 2010-04-07 | 2012-11-29 | Momenta Pharmaceuticals Inc | Glicanos de alta manosa. |
US9170249B2 (en) | 2011-03-12 | 2015-10-27 | Momenta Pharmaceuticals, Inc. | N-acetylhexosamine-containing N-glycans in glycoprotein products |
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US20160145589A1 (en) | 2011-06-24 | 2016-05-26 | Green Cross Corporation | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9695244B2 (en) | 2012-06-01 | 2017-07-04 | Momenta Pharmaceuticals, Inc. | Methods related to denosumab |
US20140004097A1 (en) * | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
US9150841B2 (en) | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
EP2906683B1 (en) | 2012-10-15 | 2017-05-31 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
AU2013381687A1 (en) | 2013-03-12 | 2015-09-24 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
US8956830B2 (en) | 2013-03-14 | 2015-02-17 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9677105B2 (en) | 2013-03-14 | 2017-06-13 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
US10450361B2 (en) | 2013-03-15 | 2019-10-22 | Momenta Pharmaceuticals, Inc. | Methods related to CTLA4-Fc fusion proteins |
US10464996B2 (en) | 2013-05-13 | 2019-11-05 | Momenta Pharmaceuticals, Inc. | Methods for the treatment of neurodegeneration |
KR20150026024A (ko) * | 2013-08-30 | 2015-03-11 | 한미약품 주식회사 | 인간 혈액응고 7인자 유도체의 대량 생산 방법 |
WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US20160257754A1 (en) | 2013-10-16 | 2016-09-08 | Momenta Pharmaceuticals Inc. | Sialylated glycoproteins |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
ES2829923T3 (es) * | 2014-10-21 | 2021-06-02 | Gennova Biopharmaceuticals Ltd | Un proceso novedoso de purificación para el aislamiento y la producción comercial de tnk-tpa recombinante (tenecteplase) |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8003402A (nl) | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
AU605124B2 (en) | 1985-12-23 | 1991-01-10 | Behringwerke Aktiengesellschaft | Novel peptide plasminogen activators |
IE81073B1 (en) | 1986-03-18 | 2000-01-12 | Genentech Inc | Modified human tissue-type plasminogen activator and its preparation |
US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
NL8700385A (nl) * | 1987-02-16 | 1988-09-16 | Tno | Het gebruik van butyraat en andere laag-molekulaire vetzuren met betrekking tot verhoging van produktie van weefsel-type plasminogeen aktivator. |
ATE135397T1 (de) | 1988-09-23 | 1996-03-15 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
-
2000
- 2000-04-21 EP EP00926245A patent/EP1171615B1/en not_active Expired - Lifetime
- 2000-04-21 AT AT00926245T patent/ATE348173T1/de active
- 2000-04-21 AU AU44806/00A patent/AU778046B2/en not_active Expired
- 2000-04-21 PT PT00926245T patent/PT1171615E/pt unknown
- 2000-04-21 IL IL14589300A patent/IL145893A0/xx unknown
- 2000-04-21 DE DE60032349T patent/DE60032349T2/de not_active Expired - Lifetime
- 2000-04-21 ES ES00926245T patent/ES2281342T3/es not_active Expired - Lifetime
- 2000-04-21 DK DK00926245T patent/DK1171615T3/da active
- 2000-04-21 US US09/553,924 patent/US6506598B1/en not_active Expired - Lifetime
- 2000-04-21 CA CA2368797A patent/CA2368797C/en not_active Expired - Lifetime
- 2000-04-21 WO PCT/US2000/010810 patent/WO2000065070A2/en active IP Right Grant
- 2000-04-21 JP JP2000614404A patent/JP4543131B2/ja not_active Expired - Lifetime
- 2000-11-27 US US09/723,545 patent/US6610516B1/en not_active Expired - Lifetime
-
2001
- 2001-10-11 IL IL145893A patent/IL145893A/en not_active IP Right Cessation
-
2005
- 2005-02-11 AU AU2005200622A patent/AU2005200622B2/en not_active Expired
-
2007
- 2007-02-20 CY CY20071100236T patent/CY1107338T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2281342T3 (es) | 2007-10-01 |
AU2005200622B2 (en) | 2007-08-23 |
CY1107338T1 (el) | 2012-12-19 |
CA2368797C (en) | 2010-08-17 |
AU2005200622A1 (en) | 2005-03-10 |
WO2000065070A9 (en) | 2001-08-02 |
AU4480600A (en) | 2000-11-10 |
IL145893A0 (en) | 2002-07-25 |
DE60032349D1 (de) | 2007-01-25 |
EP1171615B1 (en) | 2006-12-13 |
WO2000065070A2 (en) | 2000-11-02 |
IL145893A (en) | 2009-11-18 |
ATE348173T1 (de) | 2007-01-15 |
JP4543131B2 (ja) | 2010-09-15 |
JP2002542787A (ja) | 2002-12-17 |
US6506598B1 (en) | 2003-01-14 |
DE60032349T2 (de) | 2007-07-12 |
PT1171615E (pt) | 2007-03-30 |
AU778046B2 (en) | 2004-11-11 |
WO2000065070A3 (en) | 2001-07-12 |
US6610516B1 (en) | 2003-08-26 |
CA2368797A1 (en) | 2000-11-02 |
EP1171615A2 (en) | 2002-01-16 |
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