DE3484689D1 - Die verwendung des gal 1 hefe-promotors. - Google Patents
Die verwendung des gal 1 hefe-promotors.Info
- Publication number
- DE3484689D1 DE3484689D1 DE8484101937T DE3484689T DE3484689D1 DE 3484689 D1 DE3484689 D1 DE 3484689D1 DE 8484101937 T DE8484101937 T DE 8484101937T DE 3484689 T DE3484689 T DE 3484689T DE 3484689 D1 DE3484689 D1 DE 3484689D1
- Authority
- DE
- Germany
- Prior art keywords
- gene
- gal
- segment
- promotor
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/142—Interferon
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/470,911 US4661454A (en) | 1983-02-28 | 1983-02-28 | GAL1 yeast promoter linked to non galactokinase gene |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3484689D1 true DE3484689D1 (de) | 1991-07-18 |
Family
ID=23869556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8484101937T Expired - Lifetime DE3484689D1 (de) | 1983-02-28 | 1984-02-23 | Die verwendung des gal 1 hefe-promotors. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4661454A (de) |
EP (1) | EP0123811B1 (de) |
JP (1) | JPS6058077A (de) |
AT (1) | ATE64416T1 (de) |
CA (1) | CA1283373C (de) |
DE (1) | DE3484689D1 (de) |
DK (1) | DK97784A (de) |
GB (1) | GB2137208B (de) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0128743A3 (de) * | 1983-06-07 | 1985-12-27 | Genex Corporation | Expression von Fremdgenen in Hefe |
EP0132309A3 (de) * | 1983-06-27 | 1985-12-27 | The Board Of Trustees Of The Leland Stanford Junior University | Regulierbares eukaryotisches Promotorelement |
IL71555A (en) * | 1984-04-15 | 1992-06-21 | State Of Israel Israel Inst Fo | Bovine interferon |
US4990446A (en) * | 1984-12-06 | 1991-02-05 | Labofina, S.A. | Promoters for the expression of foreign genes in yeast, plasmids comprising them, and use thereof for the production of polypeptides |
US4861868A (en) * | 1985-02-22 | 1989-08-29 | Monsanto Company | Production of proteins in procaryotes |
US5037806A (en) * | 1985-02-22 | 1991-08-06 | Monsanto Company | Biologically active method using somatotropins |
EP0225887B1 (de) * | 1985-04-08 | 1994-06-08 | Amgen Inc. | Verfahren und hybridpromotor zur steuerung der exogenen gentranskription |
JP2677350B2 (ja) * | 1985-08-02 | 1997-11-17 | メルク エンド カムパニ− インコ−ポレ−テツド | 発現蛋白の発酵収率増大 |
JPH0668B2 (ja) * | 1985-08-30 | 1994-01-05 | 財団法人化学及血清療法研究所 | 単純ヘルペスウイルス遺伝子が組込まれた組換えプラスミド |
US5002876A (en) * | 1986-09-22 | 1991-03-26 | Phillips Petroleum Company | Yeast production of human tumor necrosis factor |
US5013652A (en) * | 1986-10-14 | 1991-05-07 | Genex Corporation | Composite yeast vectors |
US5882884A (en) * | 1987-06-19 | 1999-03-16 | Lucky Biotech Corporation | Expression of proteinaceous sweeteners in yeast |
US5487990A (en) * | 1988-07-01 | 1996-01-30 | The General Hospital Corporation | Glucose-regulated promoter of yeast acetyl-CoA hydrolase |
US5057419A (en) * | 1988-09-22 | 1991-10-15 | Rutgers University | Genetically engineered plasmid and organisms for the production of specialized oils |
US5187079A (en) * | 1988-12-21 | 1993-02-16 | The Research Foundation Of State University Of New York | Glucose-repressible gene for the regulated expression of proteins and expression vector therefor |
WO1991014780A1 (en) * | 1990-03-21 | 1991-10-03 | Board Of Regents, The University Of Texas System | Yeast expression vectors |
ATE199391T1 (de) | 1990-09-13 | 2001-03-15 | Univ Duke | Expression von an g-protein gekoppelten rezeptoren in hefe |
JPH04287683A (ja) * | 1991-03-14 | 1992-10-13 | Ajinomoto Co Inc | 酵母変異株およびそれを利用するペプチドまたは蛋白質 等の製造方法 |
GB9226065D0 (en) * | 1992-12-14 | 1993-02-10 | Ici Plc | Peptides |
DE4303744A1 (de) * | 1993-02-09 | 1994-08-11 | Univ Autonoma De Nuevo Leon Mo | Hundewachstumshormon |
DE19534120A1 (de) | 1995-09-14 | 1997-03-20 | Hoechst Ag | Verwendung von Cytohesin-PH-Peptiden zur Beeinflußung der Adhäsionsfähigkeit von Integrinen |
AU1206397A (en) | 1995-12-29 | 1997-07-28 | Guilford Pharmaceuticals Inc. | Method and kit for detection of multiple protein interactions |
US5886151A (en) * | 1996-05-03 | 1999-03-23 | Regents Of The University Of Minnesota | Candida albicans integrin-like protein |
CN1127568C (zh) | 1996-10-16 | 2003-11-12 | 津莫吉尼蒂克斯公司 | 成纤维细胞生长因子同系物 |
US6265186B1 (en) | 1997-04-11 | 2001-07-24 | Dsm N.V. | Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces |
GB9726897D0 (en) * | 1997-12-20 | 1998-02-18 | Zeneca Ltd | Process |
IL142164A0 (en) | 1998-09-23 | 2002-03-10 | Zymogenetics Inc | Cytokine receptor zalpha11 |
DE69939330D1 (de) | 1998-12-07 | 2008-09-25 | Zymogenetics Inc | Wachstumsfaktor-homologe zvegf-3 |
TR200101998T2 (tr) | 1999-01-07 | 2002-06-21 | Zymogenetics, Inc. | Çözünür reseptör BR 43x2 ve kullanım metodları |
US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
EP1881070B1 (de) | 1999-03-09 | 2012-10-03 | Zymogenetics, Inc. | Menschliche Zytokine als Liganden des Z-Alpha-Rezeptors und Verwendungen davon |
IL147336A0 (en) | 1999-07-07 | 2002-08-14 | Zymogenetics Inc | Human cytokine receptor |
EP2194130A1 (de) | 1999-12-23 | 2010-06-09 | ZymoGenetics, L.L.C. | Zytokin ZCYT018 |
DE60142511D1 (de) | 2000-05-11 | 2010-08-19 | Zymogenetics Inc | Zsig33-ähnliche peptide |
PT1325115T (pt) | 2000-06-26 | 2016-09-28 | Zymogenetics Inc | Recetor de citocina zcytor17 |
EP1939293A3 (de) | 2000-06-30 | 2008-07-09 | ZymoGenetics, Inc. | Interferonähnliches Protein ZCYTO21 |
EP1736545A3 (de) | 2000-08-08 | 2007-03-28 | ZymoGenetics, Inc. | Lösliche Zcyctor 11 Cytokinrezeptoren |
WO2002053747A1 (en) | 2000-12-28 | 2002-07-11 | Toyota Jidosha Kabushiki Kaisha | Process for producing prenyl alcohol |
JP2004533997A (ja) | 2001-02-20 | 2004-11-11 | ザイモジェネティクス,インコーポレイティド | Bcma及びtaciの両者を結合する抗体 |
SI1436003T1 (sl) | 2001-05-24 | 2010-02-26 | Zymogenetics Inc | TACI-imunoglobulinski fuzijski proteini |
WO2003040313A2 (en) | 2001-11-05 | 2003-05-15 | Zymogenetics, Inc | Il-21 antagonists |
US7494804B2 (en) | 2002-01-18 | 2009-02-24 | Zymogenetics, Inc. | Polynucleotide encoding cytokine receptor zcytor17 multimer |
ATE401390T1 (de) | 2002-01-18 | 2008-08-15 | Zymogenetics Inc | Zytokin (zcytor17-ligand) |
WO2003089603A2 (en) | 2002-04-19 | 2003-10-30 | Zymogenetics, Inc. | Cytokine receptor |
US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
US20080050808A1 (en) * | 2002-10-09 | 2008-02-28 | Reed Thomas D | DNA modular cloning vector plasmids and methods for their use |
US7785871B2 (en) * | 2002-10-09 | 2010-08-31 | Intrexon Corporation | DNA cloning vector plasmids and methods for their use |
ES2303132T3 (es) | 2003-08-07 | 2008-08-01 | Zymogenetics, Inc. | Preparaciones homogeneas de il-29. |
CN1283792C (zh) * | 2003-11-14 | 2006-11-08 | 余伟明 | 生物大分子组分相分离法 |
EP1732946B1 (de) | 2004-03-08 | 2011-07-27 | ZymoGenetics, Inc. | Dimere fusionsproteine und materialien und verfahren zu deren herstellung |
WO2005116231A1 (en) | 2004-05-18 | 2005-12-08 | Intrexon Corporation | Methods for dynamic vector assembly of dna cloning vector plasmids |
WO2006012644A2 (en) | 2004-07-29 | 2006-02-02 | Zymogenetics, Inc. | Use of il-28 and il-29 to treat cancer |
AU2005268917B2 (en) | 2004-08-02 | 2010-05-20 | Basf Plant Science Gmbh | Method for isolation of transcription termination sequences |
CA2596390A1 (en) | 2005-02-08 | 2006-08-17 | Zymogenetics, Inc. | Anti-il-20, anti-il-22 and anti-il-22ra antibodies and binding partners and methods of using in inflammation |
WO2006124667A2 (en) | 2005-05-12 | 2006-11-23 | Zymogenetics, Inc. | Compositions and methods for modulating immune responses |
CA2618763A1 (en) | 2005-08-09 | 2007-02-15 | Zymogenetics, Inc. | Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules |
EP1922080A2 (de) * | 2005-08-09 | 2008-05-21 | ZymoGenetics, Inc. | Verfahren zur behandlung von b-zell-malignomen mittels taci-ig-fusionsmolekül |
US8153598B2 (en) * | 2005-10-19 | 2012-04-10 | Intrexon Corporation | PKD ligands and polynucleotides encoding PKD ligands |
CN101489573B (zh) * | 2006-05-15 | 2013-05-22 | 阿雷斯贸易股份有限公司 | 用TACI-Ig融合分子治疗自身免疫疾病的方法 |
EP2164863A4 (de) | 2007-06-15 | 2010-07-28 | Univ Arkansas | Verfahren zur verabreichung von molekülen an zellen unter verwendung einer rizin-untereinheit und damit in zusammenhang stehende zusammensetzungen |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
EP2193146B1 (de) | 2007-09-14 | 2016-05-25 | Adimab, LLC | Synthetische antikörperbibliotheken mit rationalem design und ihre verwendung |
JP5474809B2 (ja) | 2007-11-21 | 2014-04-16 | ロスキレ ユニバーシティ | 氷結合活性を備えたポリペプチド |
WO2009080054A1 (en) * | 2007-12-21 | 2009-07-02 | Ifxa A/S | Protease inhibitor |
WO2009092806A2 (en) * | 2008-01-25 | 2009-07-30 | Aarhus Universitet | Selective exosite inhibition of papp-a activity against igfbp-4 |
DK2274008T3 (da) | 2008-03-27 | 2014-05-12 | Zymogenetics Inc | Sammensætninger og fremgangsmåder til hæmning af PDGFRBETA og VEGF-A |
US8658766B2 (en) | 2008-06-27 | 2014-02-25 | Zymogenetics, Inc. | Soluble hybrid Fcγ receptors and related methods |
EP2580238A1 (de) | 2010-06-09 | 2013-04-17 | Zymogenetics, Inc. | Dimere vstm3-fusionsproteine sowie zugehörige zusammensetzungen und verfahren |
DK2809795T3 (da) | 2012-02-01 | 2019-12-16 | Sgi Dna Inc | Materialer og fremgangsmåder til syntese af fejlminimerede nukleinsyremolekyler |
WO2014202089A2 (en) | 2013-06-18 | 2014-12-24 | Roskilde Universitet | Variants of anti-freeze polypeptides |
CN106318943B (zh) * | 2015-06-29 | 2019-03-05 | 中国科学院大连化学物理研究所 | 半乳糖激酶启动子和终止子及其应用 |
CN106318942B (zh) * | 2015-06-29 | 2018-12-25 | 中国科学院大连化学物理研究所 | 一种半乳糖激酶启动子和终止子及其应用 |
CA2997263C (en) | 2015-09-08 | 2022-10-04 | Theripion, Inc. | Apoa-1 fusion polypeptides and related compositions and methods |
WO2018136163A2 (en) | 2016-12-09 | 2018-07-26 | Theripion, Inc. | Tandem apoa-1 fusion polypeptides |
CN111148763B (zh) | 2017-07-20 | 2023-11-03 | Aptevo研究与开发公司 | 结合于5t4和4-1bb的抗原结合蛋白以及相关组合物和方法 |
CN111655728B (zh) | 2017-12-20 | 2022-02-22 | 和铂医药(上海)有限责任公司 | 结合ctla-4的抗体及其用途 |
US10150801B1 (en) | 2017-12-27 | 2018-12-11 | Imunami Laboratories Pte. Ltd. | Recombinant polypeptides and methods of use thereof |
WO2019132765A1 (en) | 2017-12-27 | 2019-07-04 | Imunami Laboratories Pte. Ltd. | Recombinant polypeptides and methods of use thereof |
WO2021040610A1 (en) | 2019-08-26 | 2021-03-04 | Imunami Laboratories Pte. Ltd. | Recombinant polypeptides and methods of use thereof |
US10675332B1 (en) | 2019-08-26 | 2020-06-09 | Imunami Laboratories Pte. Ltd. | Recombinant polypeptides and methods of use thereof |
CN116568317A (zh) | 2020-06-22 | 2023-08-08 | 免疫实验室私人有限公司 | 用于癌症治疗的重组多肽和组合 |
CA3206901A1 (en) | 2021-02-19 | 2022-08-25 | Theripion, Inc. | Paraoxonase fusion polypeptides and related compositions and methods |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4443539A (en) * | 1980-02-05 | 1984-04-17 | The Upjohn Company | Process for preparing bovine growth hormone |
US4666847A (en) * | 1981-01-16 | 1987-05-19 | Collaborative Research, Inc. | Recombinant DNA means and method |
NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
EP0128743A3 (de) * | 1983-06-07 | 1985-12-27 | Genex Corporation | Expression von Fremdgenen in Hefe |
EP0132309A3 (de) * | 1983-06-27 | 1985-12-27 | The Board Of Trustees Of The Leland Stanford Junior University | Regulierbares eukaryotisches Promotorelement |
-
1983
- 1983-02-28 US US06/470,911 patent/US4661454A/en not_active Expired - Lifetime
-
1984
- 1984-02-23 DE DE8484101937T patent/DE3484689D1/de not_active Expired - Lifetime
- 1984-02-23 EP EP84101937A patent/EP0123811B1/de not_active Expired - Lifetime
- 1984-02-23 AT AT84101937T patent/ATE64416T1/de not_active IP Right Cessation
- 1984-02-24 DK DK97784A patent/DK97784A/da not_active Application Discontinuation
- 1984-02-27 CA CA000448315A patent/CA1283373C/en not_active Expired - Lifetime
- 1984-02-28 GB GB08405129A patent/GB2137208B/en not_active Expired
- 1984-02-28 JP JP59035472A patent/JPS6058077A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0123811A2 (de) | 1984-11-07 |
ATE64416T1 (de) | 1991-06-15 |
JPS6058077A (ja) | 1985-04-04 |
GB2137208A (en) | 1984-10-03 |
CA1283373C (en) | 1991-04-23 |
GB2137208B (en) | 1987-05-13 |
US4661454A (en) | 1987-04-28 |
DK97784D0 (da) | 1984-02-24 |
DK97784A (da) | 1984-08-29 |
GB8405129D0 (en) | 1984-04-04 |
EP0123811B1 (de) | 1991-06-12 |
EP0123811A3 (en) | 1986-03-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |