ES8602138A1 - Metodo de controlar la expresion de un gen que codifica una proteinaheterologa deseada. - Google Patents

Metodo de controlar la expresion de un gen que codifica una proteinaheterologa deseada.

Info

Publication number
ES8602138A1
ES8602138A1 ES536492A ES536492A ES8602138A1 ES 8602138 A1 ES8602138 A1 ES 8602138A1 ES 536492 A ES536492 A ES 536492A ES 536492 A ES536492 A ES 536492A ES 8602138 A1 ES8602138 A1 ES 8602138A1
Authority
ES
Spain
Prior art keywords
control system
xenogeneic
expression
vectors containing
cells transformed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536492A
Other languages
English (en)
Other versions
ES536492A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES8602138A1 publication Critical patent/ES8602138A1/es
Publication of ES536492A0 publication Critical patent/ES536492A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

METODO PARA EL CONTROL DE LA EXPRESION DE GENES QUE CODIFICAN UNA PROTEINA HETEROLOGA DESEADA. COMPRENDE EL CULTIVO DE CELULAS TRANSFORMADAS CON UN VECTOR DE EXPRESION PARA EL GEN QUE CODIFICA LA PROTEINA HETEROLOGA, VECTOR QUE COMPRENDE UNA PRIMERA SECUENCIA DE ADN QUE CONTIENE UN PROMOTOR/OPERADOR ENLAZADO OPERATIVAMENTE AL GEN QUE CODIFICA DICHA PROTEINA, Y UNAS SEGUNDA SECUENCIA DE ADN QUE CONTIENE UN PROMOTOR INDUCIBLE ENLAZADO OPERATIVAMENTE AL GEN QUE CODIFICA UNA PROTEINA REPRESORA COMPATIBLE CON EL PROMOTOR/OPERADOR, Y SUPLEMENTARIA PARA EL HOSPEDANTE; DE MODO QUE LA PRIMERA Y SEGUNDA SECUENCIAS DE ADN SON XENOGENEICAS PARA EL HOSPEDANTE. TIENE APLICACIONES PARA LA OBTENCION DE GENES DE INSULINA, INTERFERONES, HORMONAS DE CRECIMIENTO, ETC.
ES536492A 1983-10-03 1984-10-03 Metodo de controlar la expresion de un gen que codifica una proteinaheterologa deseada. Granted ES536492A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53873083A 1983-10-03 1983-10-03

Publications (2)

Publication Number Publication Date
ES8602138A1 true ES8602138A1 (es) 1985-12-01
ES536492A0 ES536492A0 (es) 1985-12-01

Family

ID=24148175

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536492A Granted ES536492A0 (es) 1983-10-03 1984-10-03 Metodo de controlar la expresion de un gen que codifica una proteinaheterologa deseada.

Country Status (9)

Country Link
EP (1) EP0136907A3 (es)
JP (1) JPS60156390A (es)
KR (1) KR850003163A (es)
AU (1) AU3375984A (es)
DK (1) DK472084A (es)
ES (1) ES536492A0 (es)
GR (1) GR80521B (es)
IL (1) IL73149A0 (es)
ZA (1) ZA847742B (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3585176D1 (de) * 1984-06-22 1992-02-27 Hitachi Ltd Verfahren zum kontrollieren der zuechtung von rekombinanten.
US5198345A (en) * 1985-04-15 1993-03-30 Gist-Brocades N.V. Vectors in use in filamentous fungi
ATE253119T1 (de) * 1985-04-15 2003-11-15 Dsm Ip Assets Bv Verwendung des glucoamylasepromotors aus apergillus
DE3853479T2 (de) * 1987-06-24 1995-09-28 Genentech Inc Ausgeglichenes, konstitutives, induzierbares transkriptionssystem.
US5266474A (en) * 1987-06-24 1993-11-30 Genentech, Inc. Balanced inducible transcription system
US5198346A (en) * 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5096815A (en) * 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
ATE158816T1 (de) 1990-11-26 1997-10-15 Genetics Inst Expression von pace in wirtszellen und verfahren zu dessen verwendung
WO1993006217A1 (en) * 1991-09-19 1993-04-01 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
US5416008A (en) * 1991-10-01 1995-05-16 California Institute Of Technology Cross-regulation of gene expression in recombinant cells
US5629167A (en) 1994-04-19 1997-05-13 Biocine S.P.A. Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
AUPN442295A0 (en) 1995-07-26 1995-08-17 Commonwealth Scientific And Industrial Research Organisation Regulated autocrine growth of mammalian cells
WO1999013077A2 (en) * 1997-09-10 1999-03-18 President And Fellows Of Harvard College Inducible methods for repressing gene function
CA2671261A1 (en) 1997-11-06 1999-05-20 Novartis Vaccines And Diagnostics S.R.L. Neisserial antigens
PT1047784E (pt) 1998-01-14 2009-12-21 Novartis Vaccines & Diagnostic Antigénios de neisseria meningitidis
GB9808932D0 (en) 1998-04-27 1998-06-24 Chiron Spa Polyepitope carrier protein
ES2304065T3 (es) 1998-05-01 2008-09-01 Novartis Vaccines And Diagnostics, Inc. Antigenos y composiciones de neisseria meningitidis.
EP1135461A4 (en) 1998-12-02 2003-03-26 Univ Boston GENE NETWORKS FOR CONTROLLING GENE EXPRESSION
WO2000042185A1 (en) * 1999-01-11 2000-07-20 Mindset Biopharmaceuticals (Usa), Inc. Methods for regulating the stability of recombinant proteins and products useful therein
BR0010130A (pt) 1999-04-30 2002-06-04 Chiron Spa Antìgenos de neisseria conservados
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
RU2281956C2 (ru) 1999-10-29 2006-08-20 Чирон С.Р.Л. Антигенные пептиды neisseria
EP2289545B1 (en) 2000-01-17 2016-06-08 GlaxoSmithKline Biologicals SA Supplemented OMV vaccine against meningococcus
ES2330083T3 (es) 2000-10-27 2009-12-04 Novartis Vaccines And Diagnostics S.R.L. Acidos nucleicos y proteinas de estreptococos de los grupos a y b.
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
DE60236596D1 (de) 2001-07-27 2010-07-15 Novartis Vaccines & Diagnostic Antikörper gegen das meningokokken adhäsin app
RU2331435C2 (ru) 2001-12-12 2008-08-20 Чирон Срл. Иммунизация против chlamydia trachomatis
EP1572720A4 (en) 2002-05-24 2008-12-24 Nps Allelix Corp PROCESS FOR THE ENZYMATIC PRODUCTION OF GLP-2 (1-34) AND GLP-2 (1-33) PEPTIDES
AU2003239865A1 (en) 2002-05-24 2003-12-12 Restoragen Inc. Method for universal enzymatic production of bioactive peptides
CA2506318C (en) 2002-11-15 2011-07-12 Chiron Srl Unexpected surface proteins in neisseria meningitidis
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
US7829307B2 (en) 2003-11-21 2010-11-09 Nps Pharmaceuticals, Inc. Production of glucagon-like peptide 2
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
WO2008020335A2 (en) 2006-06-09 2008-02-21 Novartis Ag Immunogenic compositions for streptococcus agalactiae
WO2009104097A2 (en) 2008-02-21 2009-08-27 Novartis Ag Meningococcal fhbp polypeptides
ITMI20090946A1 (it) 2009-05-28 2010-11-29 Novartis Ag Espressione di proteine ricombinanti
NZ622048A (en) 2009-08-27 2015-10-30 Novartis Ag Hybrid polypeptides including meningococcal fhbp sequences
MX2012004850A (es) 2009-10-27 2012-05-22 Novartis Ag Polipeptidos fhbp meningococicos modificados.
FR2954349A1 (fr) 2009-12-22 2011-06-24 Agronomique Inst Nat Rech Sulfatase modifiant selectivement les glycosaminoglycanes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374927A (en) * 1981-02-24 1983-02-22 The Board Of Trustees Of The Leland Stanford Jr. University Extrachromosomal regulation of expression
DE3319242A1 (de) * 1983-05-27 1984-11-29 Battelle-Institut E.V., 6000 Frankfurt Verfahren und plasmid zur steuerung der expression von klonierten genen
ATE60803T1 (de) * 1983-06-27 1991-02-15 Genentech Inc Uebertragbare induzierbare kontrollsysteme, diese enthaltende expressionsvektoren, mit diesen transformierte mikroorganismen und ihre verwendung bei der expression von exogenem protein.

Also Published As

Publication number Publication date
DK472084A (da) 1985-05-07
JPS60156390A (ja) 1985-08-16
EP0136907A3 (en) 1986-12-30
EP0136907A2 (en) 1985-04-10
ZA847742B (en) 1985-05-29
AU3375984A (en) 1985-04-18
DK472084D0 (da) 1984-10-02
ES536492A0 (es) 1985-12-01
GR80521B (en) 1985-02-04
KR850003163A (ko) 1985-06-13
IL73149A0 (en) 1985-01-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603