ES8606887A1 - Un metodo para la produccion microbica de interferon. - Google Patents

Un metodo para la produccion microbica de interferon.

Info

Publication number
ES8606887A1
ES8606887A1 ES540038A ES540038A ES8606887A1 ES 8606887 A1 ES8606887 A1 ES 8606887A1 ES 540038 A ES540038 A ES 540038A ES 540038 A ES540038 A ES 540038A ES 8606887 A1 ES8606887 A1 ES 8606887A1
Authority
ES
Spain
Prior art keywords
novel vectors
interferon expression
interferon
expression
vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540038A
Other languages
English (en)
Other versions
ES540038A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8606887A1 publication Critical patent/ES8606887A1/es
Publication of ES540038A0 publication Critical patent/ES540038A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION MICROBICA DE INTERFERON, QUE TIENE APLICACION PARA LA PRODUCCION DE INTERFERON LEUCOCITARIO HUMANO. COMPRENDE LA TRANSFORMACION DE UN ORGANISMO DE LEVADURA SENSIBLE A LA TEMPERATURA CON UN VECTOR DE EXPRESION QUE CONTIENE EL GEL ESTRUCTURAL PARA UN INTERFERON HUMANO, ENLAZADO DE MODO OPERATIVO A UN PROMOTOR/OPERADOR PHO5; DESARROLLO DEL ORGANISMO TRANSFORMADO EN UN MEDIO DE CULTIVO ADECUADO, A UNA TEMPERATURA COMPRENDIDA ENTRE 30JC Y 35JC; DISMINUCION DE LA TEMPERATURA DEL ORGANISMO HASTA UN VALOR COMPRENDIDO ENTRE 20JC Y 30JC, PARA INDUCIR LA TEMPERATURA DE INTERFERON; LISADO DEL ORGANISMO HUESPED; Y RECUPERACION DEL INTERFERON DEL LISADO RESULTANTE.
ES540038A 1983-05-05 1985-02-01 Un metodo para la produccion microbica de interferon. Expired ES8606887A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49167283A 1983-05-05 1983-05-05

Publications (2)

Publication Number Publication Date
ES8606887A1 true ES8606887A1 (es) 1986-05-16
ES540038A0 ES540038A0 (es) 1986-05-16

Family

ID=23953166

Family Applications (2)

Application Number Title Priority Date Filing Date
ES532173A Expired ES8505411A1 (es) 1983-05-05 1984-05-04 Un metodo para producir interferon
ES540038A Expired ES8606887A1 (es) 1983-05-05 1985-02-01 Un metodo para la produccion microbica de interferon.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES532173A Expired ES8505411A1 (es) 1983-05-05 1984-05-04 Un metodo para producir interferon

Country Status (14)

Country Link
EP (1) EP0124874A3 (es)
JP (1) JPS60186288A (es)
AU (1) AU2767684A (es)
DK (1) DK224684A (es)
ES (2) ES8505411A1 (es)
FI (1) FI841787A (es)
GR (1) GR79963B (es)
HU (1) HUT34239A (es)
IL (1) IL71745A0 (es)
MC (1) MC1598A1 (es)
NO (1) NO841811L (es)
NZ (1) NZ208046A (es)
PT (1) PT78552B (es)
ZA (1) ZA843275B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0214638A3 (en) * 1985-09-09 1988-08-31 G.D. Searle & Co. Yeast promoters
JPH0655146B2 (ja) * 1985-12-27 1994-07-27 財団法人化学及血清療法研究所 シヤトルベクタ−
US5013652A (en) * 1986-10-14 1991-05-07 Genex Corporation Composite yeast vectors
DE3635867A1 (de) * 1986-10-22 1988-05-11 Boehringer Ingelheim Int Neue hefeexpressionsvektoren fuer ifn-omega, verfahren zu ihrer herstellung und deren verwendung
KR100374307B1 (ko) * 1995-07-21 2003-07-07 주식회사 엘지생명과학 재조합효모로부터발현된감마인터페론의정제방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
GB2125047B (en) * 1982-08-09 1986-02-19 Ciba Geigy Ag Yeast hybrid vectors and their use for the production of polypeptides
IL72773A0 (en) * 1983-08-29 1984-11-30 Meloy Lab Production of immune interferon and its mrna

Also Published As

Publication number Publication date
GR79963B (es) 1984-10-31
NZ208046A (en) 1988-04-29
FI841787A (fi) 1984-11-06
DK224684D0 (da) 1984-05-04
ZA843275B (en) 1984-12-24
EP0124874A2 (en) 1984-11-14
MC1598A1 (fr) 1985-05-09
AU2767684A (en) 1984-11-08
JPS60186288A (ja) 1985-09-21
EP0124874A3 (en) 1987-03-25
ES532173A0 (es) 1985-06-01
PT78552A (en) 1984-06-01
NO841811L (no) 1984-11-06
ES8505411A1 (es) 1985-06-01
IL71745A0 (en) 1984-09-30
ES540038A0 (es) 1986-05-16
FI841787A0 (fi) 1984-05-04
HUT34239A (en) 1985-02-28
DK224684A (da) 1984-11-06
PT78552B (en) 1986-09-15

Similar Documents

Publication Publication Date Title
ATE43634T1 (de) Maltose erzeugendes amylase-enzymprodukt, dessen herstellung und dessen verwendung.
UA19162A (uk) Спосіб одержаhhя аhтибіотика s541, штами стрептоміцетів - продуцеhти аhтибіотика s541
ES8602138A1 (es) Metodo de controlar la expresion de un gen que codifica una proteinaheterologa deseada.
MX165920B (es) Un procedimiento para producir glucoamilasa
IL68366A (en) Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
AU7450887A (en) Novel human TNF polypeptide mutants and DNAs encoding said mutants
DK139493A (da) Rekombinant plasmid, bakteriekultur transformeret dermed samt kulturens anvendelse
AU3496484A (en) Method of culturing freeze-dried microorganisms
DE3478699D1 (en) Method for producing interferons
DE3683267D1 (de) Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung.
ES360055A1 (es) Un procedimiento para obtener preparados en enzimas proteo-liticas.
ES8606887A1 (es) Un metodo para la produccion microbica de interferon.
ES2057183T3 (es) Procedimiento para la obtencion de lisozima humano.
ES8600400A1 (es) Un procedimiento para la produccion de histidina
DE3272012D1 (en) Process for the preparation of acid protease
BG33589A3 (en) Method for glucoseisomeric enzime obtaining
DE3783299D1 (de) Herstellung von mikroorganismen mit eiskristallbildungsaktivitaet.
EP0075904A3 (en) Process for culturing human fibroblasts and fibroblast-like cells
ATE22702T1 (de) Herstellung von glucosedehydrogenase.
ES477271A1 (es) Procedimiento para la produccion o el mantenimiento de un cultivo estable de un microorganismo del genero lactovaci- llus.
GB2162198B (en) Process for producing dense nutrient medium for culturing microorganisms and macroorganism cell cultures
DE3677421D1 (de) Mikrobiologisches verfahren zur herstellung von menschlichem lysozym.
ES8705041A1 (es) Un metodo para producir interleuquina-2
DK138984A (da) Plasmid, fremgangsmaade til fremstilling heraf, mikroorganismer indeholdende samme samt fremgangsmaade til dyrkning af mikroorganismen
IL75118A0 (en) Additives for use in cell culture,culture medium for non-serum cultivation and method of cell culture using them

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009