ES8705041A1 - Un metodo para producir interleuquina-2 - Google Patents

Un metodo para producir interleuquina-2

Info

Publication number
ES8705041A1
ES8705041A1 ES552846A ES552846A ES8705041A1 ES 8705041 A1 ES8705041 A1 ES 8705041A1 ES 552846 A ES552846 A ES 552846A ES 552846 A ES552846 A ES 552846A ES 8705041 A1 ES8705041 A1 ES 8705041A1
Authority
ES
Spain
Prior art keywords
interleukin
production
medium
escherichia coli
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552846A
Other languages
English (en)
Other versions
ES552846A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8705041A1 publication Critical patent/ES8705041A1/es
Publication of ES552846A0 publication Critical patent/ES552846A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE INTERLEUQUINA-2. CONSISTE EN CULTIVAR UN TRANSFORMANTE DE ESCHERICHIA COLI QUE CONTIENE ADN QUE CODIFICA INTERLEUQUINA-2 O UN POLIPEPTIDO QUE TIENE ACTIVIDAD FISIOLOGICA SIMILAR A ESTA, EN UN MEDIO A UN PH AJUSTADO ENTRE 4,8 A 6,0, AJUSTADO MEDIANTE UNA BASE INORGANICA, TAL COMO AMONIACO, CON AIREACION Y AGITACION, A UNA TEMPERATURA PROXIMA A 30JC HASTA LA FASE MEDIA DE CRECIMIENTO, Y QUE DESPUES SE MANTIENE ENTRE 20JC Y 30JC. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO AGENTE ANTITUMORAL.
ES552846A 1985-03-11 1986-03-10 Un metodo para producir interleuquina-2 Expired ES8705041A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60048698A JPH0646957B2 (ja) 1985-03-11 1985-03-11 インタ−ロイキン−２の製造方法

Publications (2)

Publication Number Publication Date
ES8705041A1 true ES8705041A1 (es) 1987-04-16
ES552846A0 ES552846A0 (es) 1987-04-16

Family

ID=12810526

Family Applications (1)

Application Number Title Priority Date Filing Date
ES552846A Expired ES8705041A1 (es) 1985-03-11 1986-03-10 Un metodo para producir interleuquina-2

Country Status (8)

Country Link
US (1) US4935356A (es)
EP (1) EP0194818A3 (es)
JP (1) JPH0646957B2 (es)
KR (1) KR930002737B1 (es)
CN (1) CN1006903B (es)
DK (1) DK104986A (es)
ES (1) ES8705041A1 (es)
IL (1) IL78074A0 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3712985A1 (de) * 1987-04-16 1988-11-03 Hoechst Ag Bifunktionelle proteine
SU1703693A1 (ru) * 1987-02-09 1992-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Рекомбинантна плазмидна ДНК @ - @ 2-19, кодирующа синтез интерлейкина-2 человека, способ ее конструировани @ штамм бактерий ЕSснеRIснIа coLI - продуцент интерлейкина-2 человека
WO1991005052A1 (en) * 1989-09-28 1991-04-18 Leningradsky Gosudarstvenny Universitet Method for obtaining a polypeptide with human-interleukin-2 activity, secreted by yeast cells, saccharomyces cerevisiae
WO1991005051A1 (en) * 1989-09-28 1991-04-18 Leningradsky Gosudarstvenny Universitet Method of obtaining human-interleukin-2 polypeptide in yeast cells
JP6363326B2 (ja) * 2013-03-11 2018-07-25 株式会社コーセー 酵母・細菌共通培養方法およびこれに用いる酵母・細菌共通培養培地

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49126882A (es) * 1973-04-19 1974-12-04
JPS5685289A (en) * 1979-12-13 1981-07-11 Ajinomoto Co Inc Preparation of l-valine by fermentation
US4357422A (en) * 1980-08-14 1982-11-02 Massachusetts Institute Of Technology Method of enhancing interferon production
JPS59140898A (ja) * 1982-12-27 1984-08-13 Japan Found Cancer インタ−ロイキン−２の製造法
DE3377363D1 (en) * 1982-03-31 1988-08-18 Ajinomoto Kk Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
CA1341562C (en) * 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
US4499188A (en) * 1982-05-05 1985-02-12 Cetus Corporation Bacterial production of heterologous polypeptides under the control of a repressible promoter-operator
JPS60115528A (ja) * 1983-11-28 1985-06-22 Takeda Chem Ind Ltd ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions

Also Published As

Publication number Publication date
CN1006903B (zh) 1990-02-21
KR930002737B1 (ko) 1993-04-09
DK104986D0 (da) 1986-03-07
CN86101353A (zh) 1986-09-10
JPS61205497A (ja) 1986-09-11
ES552846A0 (es) 1987-04-16
EP0194818A3 (en) 1988-05-18
EP0194818A2 (en) 1986-09-17
JPH0646957B2 (ja) 1994-06-22
KR860007376A (ko) 1986-10-10
US4935356A (en) 1990-06-19
DK104986A (da) 1986-09-12
IL78074A0 (en) 1986-07-31

Similar Documents

Publication Publication Date Title
EP0156355A3 (en) Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
ES458982A1 (es) Un proceso para la produccion de glicerol y sustancias pro- teinicas de valor nutritivo.
DE3479321D1 (en) Biosynthetically produced human nerve growth factor, process for producing it, compositions containing it, dna sequence encoding it, vectors containing the sequence and host cells transformed thereby
ES8502476A1 (es) Un procedimiento para obtener polipeptidos similares a la hormona del crecimiento de ganado bovino
IE840294L (en) Production of organic acids
IL74552A (en) Process for the microbiological production of l-carnitine and method for deriving micro-organisms suitable for said process
ES8706206A1 (es) Procedimiento para preparar un compuesto de furano
KR840004502A (ko) 발효된 해바라기씨 분말과 이들의 제조방법
ES8705041A1 (es) Un metodo para producir interleuquina-2
ES425461A1 (es) Un procedimiento para el cultivo continuo de proteinas mo- nocelulares.
CS66292A3 (en) Microbiological process for preparing s-(+)-2,2-dimethylcyclopropanecarboxamide
MY104233A (en) Production of human prourokinase.
EP0233733A3 (en) Process for producing n-phthaloyl-p-nitro-l-phenylalanine
AU6628081A (en) Microbiological production of the amino acid sequences of proinsulin from primates
AU4442085A (en) Production of l-amino acids form ketoacid precursors by biological transamination
ES8704543A1 (es) Procedimiento para preparar un microorganismo
ES8606887A1 (es) Un metodo para la produccion microbica de interferon.
NZ215994A (en) Culturing e.coli to produce interferon alpha and gamma and interleukin-2
DE3480216D1 (en) Process for producing arphamenine in high yield
AU6108586A (en) Process for the production of sorbitol by enzymatic reaction, and microorganisms suitable for the purpose
GB1394849A (en) 5-dihydrocoriolin c and process for producing the same
ITMI913375A1 (it) Procedimento per la produzione di neuraminidasi
JPS5763089A (en) Production of cytosine deaminase and culture medium therefor
PT80996A (en) Process for preparing 6-fluoro-chroman-4-carboxylic acid derivatives
IE45014L (en) Antibiotic a-7413.

Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506