JP2002017376A - 分泌蛋白質、または膜蛋白質 - Google Patents

Abstract

(57)【要約】 【課題】 新規なヒト分泌蛋白質、または膜蛋白質と、
それをコードする全長cDNAの提供。 【解決手段】 １７３種のヒト分泌蛋白質、または膜蛋
白質とそれをコードする全長cDNAを単離した。本発明の
蛋白質は、自身が医薬品の候補化合物として有用であ
る。あるいは、医薬品開発の標的分子として有用であ
る。また本発明による全長cDNAは、これらの蛋白質の生
産のために利用される。

Description

【発明の詳細な説明】

【０００１】

【発明の属する技術分野】本発明は、新規な蛋白質をコ
ードするポリヌクレオチド、このポリヌクレオチドによ
ってコードされる蛋白質、及びそれらの新規な用途に関
する。

【０００２】

【従来の技術】現在、世界的なレベルで様々な生物のゲ
ノム配列の解明とその解析が進められている。既に10種
類を越える原核微生物、下等真核生物の出芽酵母、多細
胞性真核生物である線虫で、その全ゲノム配列が決定さ
れた。3,000,000,000塩基対といわれるヒトのゲノムに
ついては、現在、世界的な協力体制のもとでその解析が
進められており、2002〜2003年頃までには、その全構造
が明らかにされようとしている。ゲノム配列を明らかに
する目的は、全ての遺伝子の機能や制御、あるいは遺伝
子間、蛋白質間、細胞間さらには個体間における相互作
用のネットワークとして複雑な生命現象を理解するとこ
ろにある。種々の生物種のゲノム情報から生命現象を解
明していくことは、単に学術分野における研究課題とし
て重要であるのみならず、そこで得られる研究成果をい
かに産業上の応用へと発展させていくかという点で、そ
の社会的な意義も大きい。ところが単にゲノム配列を決
定しただけでは、全ての遺伝子の機能を明らかにできる
わけではない。例えば酵母では、ゲノム配列から推定さ
れた約6,000の遺伝子の約半数しか、その機能を推定で
きなかった。一方、ヒトには約100,000種類の遺伝子が
存在するといわれる。そこで、ゲノム配列から明らかに
されてくる膨大な量の新しい遺伝子の機能を、迅速かつ
効率的に解明していくための「ハイスループット遺伝子
機能解析システム」の確立が、強く望まれている。

【０００３】真核生物のゲノム配列では、多くの場合、
一つの遺伝子がイントロンによって複数のエキソンに分
断されている。そのため、ゲノム配列情報だけからそこ
にコードされる蛋白質の構造を正確に予測するには、多
くの問題がある。一方、イントロンが除かれたmRNAから
作製されるcDNAでは、蛋白質のアミノ酸配列の情報が一
つの連続した配列情報として得られるため、容易にその
一次構造を明らかにすることが可能である。ヒトのcDNA
の研究では、これまでに1,000,000を越えるEST（Expres
sion Sequence Tags）データがパブリックドメインに公
開されており、それらはヒトの全遺伝子の80%以上をカ
バーしているものと推定されている。これらの情報は、
ヒト遺伝子構造の解明やゲノム配列におけるエキソン領
域の予測、あるいはその発現プロファイルの推定など、
様々な角度から利用されている。ところが、これらのヒ
トEST情報の多くはcDNAの3′末端側近傍に集中している
ため、特にmRNAの5′末端近傍の情報が極端に不足して
いる状況にある。また、これらのヒトcDNAの中でコード
されている蛋白質の配列が予測されているmRNAは約7,00
0種類程度であり、更にそのうち全長cDNAクローンとし
て取得されているものはわずか5,500種類程度に過ぎな
いのが現状である。ESTとして登録されているものを含
めても、全長クローンとしてこれまでに取得されている
ヒトcDNAは、ヒト全遺伝子のわずかに10%〜15%程度であ
ると推定されている。

【０００４】完全長cDNAを取得できれば、その5′末端
配列からゲノム配列上でのmRNA転写開始点が特定できる
上、その配列の中に含まれるmRNAの安定性や翻訳段階で
の発現制御に関わる因子の解析が可能である。また、翻
訳開始点であるatgを5'側に含むことから、正しいフレ
ームで蛋白質への翻訳を行うことができる。したがっ
て、適当な遺伝子発現系を適用することで、そのcDNAが
コードする蛋白質を大量に生産したり、蛋白質を発現さ
せてその生物学的活性を解析することも可能になる。こ
のように、完全長cDNAの解析からはゲノム配列解析を相
補する重要な情報が得られる。また、発現可能な全長cD
NAクローンは、その遺伝子の機能の実証的な解析や産業
分野での応用への展開において、その重要性はきわめて
高い。

【０００５】特にヒト分泌蛋白質、または膜蛋白質に
は、そのものがティッシュープラスミノーゲンアクチベ
ーター (TPA)のように、医薬品として有用なものや、膜
レセプターのように医薬品の標的蛋白質になりうるもの
が多い。したがって、ヒトにおいて分離が進んでいない
新規な全長cDNAを提供する意義は大きい。中でも、分泌
蛋白質、または膜蛋白質をコードするcDNAは、蛋白質自
身、あるいは膜蛋白質と相互作用する分子に医薬品とし
ての有用性を期待できること、あるいは疾患に関連する
遺伝子を多く含む可能性のあることから、未知のcDNAの
分離が望まれている。したがって、これらの蛋白質をコ
ードするcDNAの全長を明らかにすることには大きな意義
がある。

【０００６】

【発明が解決しようとする課題】本発明は、新規な蛋白
質をコードするポリヌクレオチド、該ポリヌクレオチド
によってコードされる蛋白質、またそれらの新規な用途
の提供を課題としている。

【０００７】

【課題を解決するための手段】本発明者らは、オリゴキ
ャップ法 [K. Maruyama and S. Sugano, Gene, 138:171
-174 (1994); Y. Suzuki et al., Gene, 200: 149-156
(1997)]で作成した全長率の高いヒトcDNAライブラリー
から、ATGpr 等を用いてヒト全長cDNAを効率よくクロー
ニングする方法を開発した。次いで、この方法で取得し
たcDNAクローンの塩基配列を5'側と3'側の両側から決定
した。こうして得られた塩基配列を利用し、PSORT [K.
Nakai & M. Kanehisa, Genomics, 14: 897-911 (1992)]
でシグナル配列を持つと予測されるクローンを特異的に
選別し、分泌蛋白質、または膜蛋白質をコードするcDNA
を有すると予測されるクローンを取得した。本発明者ら
は、このようにして選別された全長cDNAクローンの5'側
の塩基配列に基づいて設定されるプライマーと、オリゴ
dTプライマー、あるいは各クローンの3'側の塩基配列に
基づいて設定することができる3'側プライマーとの組み
合わせによって、新規な全長cDNAを合成することができ
ることを見出した。また本発明における全長cDNAクロー
ンは、[1]オリゴキャップ法による全長率の高いcDNAラ
イブラリーの作成、および[2]5'末端側の配列からの全
長性の評価システムとの組み合わせによって取得するこ
とができた、全長cDNAクローンである。更に、この方法
で取得したクローンの全長cDNA配列を解析し、その塩基
配列がコードするアミノ酸配列を推定した。そして推定
アミノ酸配列に基づいて、BLAST [S. F. Altschul, W.
Gish, W. Miller, E. W. Myers & D. J. Lipman, J. Mo
l. Biol., 215: 403-410 (1990); W. Gish & D. J. Sta
tes, Nature Genet., 3:266-272 (1993); http://www.
ncbi.nlm.nih.gov/BLAST/]によりGenBank (http://www.
ncbi.nlm.nih.gov/Web/Genbank/index.html)やSwissPro
t (http://www.ebi.ac.uk/ebi_docs/swissprot_db/ swi
sshome.html)を利用して相同性解析を行い、推定アミノ
酸配列を持つ蛋白質に予測される機能を明らかにして本
発明を完成した。cDNAの部分的な断片配列に対して相同
性解析を行って、該断片がコードする蛋白質の機能を推
定することが行われている。このような解析手法は、断
片の情報に基づいているので、該断片が蛋白質の機能的
に重要な部分に対応しているかどうかは不明である。つ
まり、断片の情報の基づく解析方法においては、蛋白質
全体の構造に関する情報が存在しないので、相同性解析
の信頼性には疑問が残る。一方、本発明の相同性解析
は、cDNAの全コード領域を含む全長cDNAの情報に基づい
て行われているので、蛋白質のあらゆる部分に対する相
同性を解析することができる。したがって本発明におい
ては、相同性解析の信頼性が飛躍的に向上している。

【０００８】すなわち本発明は、以下のポリヌクレオチ
ド、このポリヌクレオチドによってコードされる蛋白
質、並びにそれらの用途に関する。まず本発明は、
〔１〕下記（ａ）から（ｆ）のいずれかに記載のポリヌ
クレオチドに関する。 （ａ）表１に記載の配列番号から選択される、いずれか
の配列番号として記載された塩基配列の蛋白質コード領
域を含むポリヌクレオチド。 （ｂ）表１に記載の配列番号から選択される、いずれか
の配列番号として記載されたアミノ酸配列からなる蛋白
質をコードする塩基配列を含むポリヌクレオチド （ｃ）表１に記載の配列番号から選択される、いずれか
の配列番号として記載されたアミノ酸配列において、１
若しくは複数のアミノ酸が置換、欠失、挿入、および／
または付加したアミノ酸配列からなり、前記選択された
アミノ酸配列からなる蛋白質と機能的に同等な蛋白質を
コードする塩基配列を含むポリヌクレオチド。 （ｄ）表１に記載の配列番号から選択される、いずれか
の配列番号として記載された塩基配列からなるポリヌク
レオチドとハイブリダイズするポリヌクレオチドであっ
て、前記選択された塩基配列によってコードされる蛋白
質と機能的に同等な蛋白質をコードする塩基配列を含む
ポリヌクレオチド。 （ｅ）（ａ）から（ｄ）に記載のポリヌクレオチドによ
ってコードされる蛋白質の部分アミノ酸配列をコードす
る塩基配列を含むポリヌクレオチド。 （ｆ）表１に記載の配列番号から選択される、いずれか
の配列番号として記載された塩基配列に対して少なくと
も７０％の同一性を有する塩基配列を含むポリヌクレオ
チド。

【０００９】表１に、本発明による全長cDNAを有する実
施例で単離したcDNAクローンの名称と、そのcDNAの塩基
配列を表す配列番号、ならびにcDNAの塩基配列から推定
されるアミノ酸配列を記載した配列番号の対応をまとめ
た。

【表１】 ━━━━━━━━━━━━━━━━━━━━━━━ アミノ酸配列 塩基配列 クローン名 ────────────────────── 配列番号：２ 配列番号：１ PSEC0001 配列番号：４ 配列番号：３ nnnnnnnn 配列番号：６ 配列番号：５ PSEC0005 配列番号：８ 配列番号：７ PSEC0007 配列番号：１０ 配列番号：９ PSEC0008 配列番号：１２ 配列番号：１１ PSEC0012 配列番号：１４ 配列番号：１３ PSEC0017 配列番号：１６ 配列番号：１５ PSEC0019 配列番号：１８ 配列番号：１７ PSEC0020 配列番号：２０ 配列番号：１９ PSEC0021 配列番号：２２ 配列番号：２１ PSEC0028 配列番号：２４ 配列番号：２３ PSEC0029 配列番号：２６ 配列番号：２５ PSEC0030 配列番号：２８ 配列番号：２７ PSEC0031 配列番号：３０ 配列番号：２９ PSEC0035 配列番号：３２ 配列番号：３１ PSEC0038 配列番号：３４ 配列番号：３３ PSEC0040 配列番号：３６ 配列番号：３５ PSEC0041 配列番号：３８ 配列番号：３７ PSEC0045 配列番号：４０ 配列番号：３９ PSEC0048 配列番号：４２ 配列番号：４１ PSEC0049 配列番号：４４ 配列番号：４３ PSEC0051 配列番号：４６ 配列番号：４５ PSEC0052 配列番号：４８ 配列番号：４７ PSEC0053 配列番号：５０ 配列番号：４９ PSEC0055 配列番号：５２ 配列番号：５１ PSEC0059 配列番号：５４ 配列番号：５３ PSEC0061 配列番号：５６ 配列番号：５５ PSEC0068 配列番号：５８ 配列番号：５７ PSEC0070 配列番号：６０ 配列番号：５９ PSEC0071 配列番号：６２ 配列番号：６１ PSEC0072 配列番号：６４ 配列番号：６３ PSEC0073 配列番号：６６ 配列番号：６５ PSEC0074 配列番号：６８ 配列番号：６７ PSEC0075 配列番号：７０ 配列番号：６９ PSEC0076 配列番号：７２ 配列番号：７１ PSEC0077 配列番号：７４ 配列番号：７３ PSEC0079 配列番号：７６ 配列番号：７５ PSEC0080 配列番号：７８ 配列番号：７７ PSEC0081 配列番号：８０ 配列番号：７９ PSEC0082 配列番号：８２ 配列番号：８１ PSEC0085 配列番号：８４ 配列番号：８３ PSEC0086 配列番号：８６ 配列番号：８５ PSEC0087 配列番号：８８ 配列番号：８７ PSEC0088 配列番号：９０ 配列番号：８９ PSEC0090 配列番号：９２ 配列番号：９１ PSEC0094 配列番号：９４ 配列番号：９３ PSEC0095 配列番号：９６ 配列番号：９５ PSEC0098 配列番号：９８ 配列番号：９７ PSEC0099 配列番号：１００ 配列番号：９９ PSEC0100 配列番号：１０２ 配列番号：１０１ PSEC0101 配列番号：１０４ 配列番号：１０３ PSEC0104 配列番号：１０６ 配列番号：１０５ PSEC0105 配列番号：１０８ 配列番号：１０７ PSEC0106 配列番号：１１０ 配列番号：１０９ PSEC0107 配列番号：１１２ 配列番号：１１１ PSEC0108 配列番号：１１４ 配列番号：１１３ PSEC0109 配列番号：１１６ 配列番号：１１５ PSEC0110 配列番号：１１８ 配列番号：１１７ PSEC0111 配列番号：１２０ 配列番号：１１９ PSEC0112 配列番号：１２２ 配列番号：１２１ PSEC0113 配列番号：１２４ 配列番号：１２３ PSEC0119 配列番号：１２６ 配列番号：１２５ PSEC0120 配列番号：１２８ 配列番号：１２７ PSEC0121 配列番号：１３０ 配列番号：１２９ PSEC0124 配列番号：１３２ 配列番号：１３１ PSEC0125 配列番号：１３４ 配列番号：１３３ PSEC0126 配列番号：１３６ 配列番号：１３５ PSEC0127 配列番号：１３８ 配列番号：１３７ PSEC0128 配列番号：１４０ 配列番号：１３９ PSEC0129 配列番号：１４２ 配列番号：１４１ PSEC0130 配列番号：１４４ 配列番号：１４３ PSEC0131 配列番号：１４６ 配列番号：１４５ PSEC0133 配列番号：１４８ 配列番号：１４７ PSEC0134 配列番号：１５０ 配列番号：１４９ PSEC0135 配列番号：１５２ 配列番号：１５１ PSEC0136 配列番号：１５４ 配列番号：１５３ PSEC0137 配列番号：１５６ 配列番号：１５５ PSEC0139 配列番号：１５８ 配列番号：１５７ PSEC0143 配列番号：１６０ 配列番号：１５９ PSEC0144 配列番号：１６２ 配列番号：１６１ nnnnnnnn 配列番号：１６４ 配列番号：１６３ PSEC0147 配列番号：１６６ 配列番号：１６５ PSEC0149 配列番号：１６８ 配列番号：１６７ PSEC0150 配列番号：１７０ 配列番号：１６９ PSEC0151 配列番号：１７２ 配列番号：１７１ PSEC0152 配列番号：１７４ 配列番号：１７３ PSEC0158 配列番号：１７６ 配列番号：１７５ PSEC0159 配列番号：１７８ 配列番号：１７７ PSEC0161 配列番号：１８０ 配列番号：１７９ PSEC0162 配列番号：１８２ 配列番号：１８１ PSEC0163 配列番号：１８４ 配列番号：１８３ PSEC0164 配列番号：１８６ 配列番号：１８５ PSEC0165 配列番号：１８８ 配列番号：１８７ PSEC0167 配列番号：１９０ 配列番号：１８９ PSEC0168 配列番号：１９２ 配列番号：１９１ PSEC0169 配列番号：１９４ 配列番号：１９３ PSEC0170 配列番号：１９６ 配列番号：１９５ PSEC0171 配列番号：１９８ 配列番号：１９７ PSEC0172 配列番号：２００ 配列番号：１９９ PSEC0173 配列番号：２０２ 配列番号：２０１ PSEC0178 配列番号：２０４ 配列番号：２０３ PSEC0181 配列番号：２０６ 配列番号：２０５ PSEC0182 配列番号：２０８ 配列番号：２０７ PSEC0183 配列番号：２１０ 配列番号：２０９ PSEC0190 配列番号：２１２ 配列番号：２１１ PSEC0191 配列番号：２１４ 配列番号：２１３ PSEC0192 配列番号：２１６ 配列番号：２１５ PSEC0197 配列番号：２１８ 配列番号：２１７ PSEC0198 配列番号：２２０ 配列番号：２１９ PSEC0199 配列番号：２２２ 配列番号：２２１ PSEC0200 配列番号：２２４ 配列番号：２２３ PSEC0203 配列番号：２２６ 配列番号：２２５ PSEC0204 配列番号：２２８ 配列番号：２２７ PSEC0205 配列番号：２３０ 配列番号：２２９ PSEC0207 配列番号：２３２ 配列番号：２３１ PSEC0209 配列番号：２３４ 配列番号：２３３ PSEC0210 配列番号：２３６ 配列番号：２３５ PSEC0213 配列番号：２３８ 配列番号：２３７ PSEC0214 配列番号：２４０ 配列番号：２３９ PSEC0215 配列番号：２４２ 配列番号：２４１ PSEC0216 配列番号：２４４ 配列番号：２４３ PSEC0218 配列番号：２４６ 配列番号：２４５ PSEC0220 配列番号：２４８ 配列番号：２４７ PSEC0222 配列番号：２５０ 配列番号：２４９ PSEC0223 配列番号：２５２ 配列番号：２５１ PSEC0224 配列番号：２５４ 配列番号：２５３ PSEC0226 配列番号：２５６ 配列番号：２５５ PSEC0227 配列番号：２５８ 配列番号：２５７ PSEC0228 配列番号：２６０ 配列番号：２５９ PSEC0230 配列番号：２６２ 配列番号：２６１ PSEC0232 配列番号：２６４ 配列番号：２６３ PSEC0233 配列番号：２６６ 配列番号：２６５ PSEC0235 配列番号：２６８ 配列番号：２６７ PSEC0236 配列番号：２７０ 配列番号：２６９ PSEC0240 配列番号：２７２ 配列番号：２７１ PSEC0241 配列番号：２７４ 配列番号：２７３ PSEC0243 配列番号：２７６ 配列番号：２７５ PSEC0244 配列番号：２７８ 配列番号：２７７ PSEC0245 配列番号：２８０ 配列番号：２７９ PSEC0246 配列番号：２８２ 配列番号：２８１ PSEC0247 配列番号：２８４ 配列番号：２８３ PSEC0248 配列番号：２８６ 配列番号：２８５ PSEC0249 配列番号：２８８ 配列番号：２８７ PSEC0250 配列番号：２９０ 配列番号：２８９ PSEC0252 配列番号：２９２ 配列番号：２９１ PSEC0253 配列番号：２９４ 配列番号：２９３ PSEC0255 配列番号：２９６ 配列番号：２９５ PSEC0258 配列番号：２９８ 配列番号：２９７ PSEC0259 配列番号：３００ 配列番号：２９９ PSEC0260 配列番号：３０２ 配列番号：３０１ PSEC0261 配列番号：３０４ 配列番号：３０３ PSEC0263 配列番号：３０６ 配列番号：３０５ PSEC0027 配列番号：３０８ 配列番号：３０７ PSEC0047 配列番号：３１０ 配列番号：３０９ PSEC0066 配列番号：３１２ 配列番号：３１１ nnnnnnnn 配列番号：３１４ 配列番号：３１３ PSEC0069 配列番号：３１６ 配列番号：３１５ PSEC0092 配列番号：３１８ 配列番号：３１７ PSEC0103 配列番号：３２０ 配列番号：３１９ PSEC0117 配列番号：３２２ 配列番号：３２１ PSEC0142 配列番号：３２４ 配列番号：３２３ PSEC0212 配列番号：３２６ 配列番号：３２５ PSEC0239 配列番号：３２８ 配列番号：３２７ PSEC0242 配列番号：３３０ 配列番号：３２９ PSEC0251 配列番号：３３２ 配列番号：３３１ PSEC0256 配列番号：３３４ 配列番号：３３３ PSEC0195 配列番号：３３６ 配列番号：３３５ PSEC0206 配列番号：３４２ 配列番号：３４１ PSEC0078 配列番号：３４４ 配列番号：３４３ PSEC0084 配列番号：３４６ 配列番号：３４５ PSEC0237 配列番号：３４８ 配列番号：３４７ PSEC0264 配列番号：３５０ 配列番号：３４９ PSEC0265 ━━━━━━━━━━━━━━━━━━━━━━━

【００１０】更に本発明は、上記ポリヌクレオチドとそ
れによってコードされる蛋白質、ならびにこれらに基づ
く以下の用途に関する。 〔２〕〔１〕に記載のポリヌクレオチドのいずれか一つ
によってコードされる蛋白質。 〔３〕配列番号：３７０〜配列番号：５４０のいずれか
の塩基配列からなるポリヌクレオチド、またはその相補
鎖に相補的な少なくとも１５塩基の鎖長を有するオリゴ
ヌクレオチドからなる、前記ポリヌクレオチドまたはそ
の相補鎖の合成に用いるためのプライマー。 〔４〕配列番号：３７０〜配列番号：５４０のいずれか
の塩基配列からなるポリヌクレオチドの相補鎖に相補的
な少なくとも１５塩基の鎖長を有するオリゴヌクレオチ
ドからなるプライマーのいずれかと、オリゴdTプライマ
ーとで構成される、ポリヌクレオチド合成用のプライマ
ーセット。 〔５〕表３４２において対応付けられている配列番号に
記載された5'側と3'側を規定する塩基配列からなるポリ
ヌクレオチドに対して、5'側の塩基配列についてはその
相補配列、そして3'側の塩基配列についてはその塩基配
列に対して相補的な塩基配列を含む少なくとも１５塩基
の鎖長を有するオリゴヌクレオチドの組み合わせのいず
れかからなる、ポリヌクレオチド合成用のプライマーセ
ット。 〔６〕〔４〕または〔５〕に記載されたいずれか１組の
プライマーセットによって合成することができるポリヌ
クレオチド。 〔７〕〔６〕に記載のポリヌクレオチドにおける蛋白質
コード領域を含むポリヌクレオチド。 〔８〕〔７〕に記載のポリヌクレオチドがコードする蛋
白質。

〔９〕〔８〕に記載の蛋白質の部分ペプチド。 〔１０〕〔２〕、〔８〕、または

〔９〕に記載されたい
ずれかの蛋白質、またはペプチドに結合する抗体。 〔１１〕〔１〕、または〔７〕に記載されたポリヌクレ
オチドのいずれか一つを含むベクター。 〔１２〕〔１〕、または〔７〕に記載されたポリヌクレ
オチドのいずれか一つ、または〔１１〕に記載のベクタ
ーを保持する形質転換体。 〔１３〕〔１〕、または〔７〕に記載されたポリヌクレ
オチドのいずれか一つ、または〔１１〕に記載のベクタ
ーを発現可能に保持する形質転換体。 〔１４〕〔１３〕に記載の形質転換体を培養し、発現産
物を回収する工程を含む、〔２〕、〔８〕、または

〔９〕に記載されたいずれかの蛋白質またはペプチドの
製造方法。 〔１５〕表１に記載の配列番号から選択される、いずれ
かの配列番号として記載された塩基配列、またはその相
補鎖に相補的な塩基配列からなる１５ヌクレオチド以上
の鎖長を持つオリゴヌクレオチド。 〔１６〕〔１５〕に記載のオリゴヌクレオチドからな
る、ポリヌクレオチド合成用プライマー。 〔１７〕〔１５〕に記載のオリゴヌクレオチドからな
る、遺伝子の検出用プローブ。 〔１８〕〔１〕に記載のいずれかのポリヌクレオチドも
しくはその一部に対するアンチセンスポリヌクレオチ
ド。 〔１９〕次の工程を含む、ポリヌクレオチドの合成方
法。 ａ）cDNAライブラリーを鋳型として、〔４〕もしくは
〔５〕に記載されたいずれか１組のプライマーセット、
または〔１６〕に記載のプライマーを起点とする相補鎖
合成反応を行い、 ｂ）合成産物を回収する。 〔２０〕cDNAライブラリーが、オリゴキャップ法によっ
て合成されたものである〔１９〕に記載の合成方法。 〔２１〕相補鎖の合成をＰＣＲ法によって行う〔１９〕
に記載の合成方法。 〔２２〕次の工程を含む、〔１〕に記載のポリヌクレオ
チドの検出方法。 ａ）標的ポリヌクレオチドと〔１５〕に記載のオリゴヌ
クレオチドを、ハイブリダイゼーションが可能な条件下
でインキュベートする工程、 ｂ）標的ポリヌクレオチドと〔１５〕に記載のオリゴヌ
クレオチドのハイブリダイゼーションを検出する工程。 〔２３〕表１に記載の配列番号から選択される、いずれ
かの配列番号として記載された塩基配列および／または
表１に記載の配列番号から選択される、いずれかの配列
番号として記載されたアミノ酸配列から選択された少な
くとも１つの配列情報を含むポリヌクレオチドおよび／
または蛋白質データベース、またはそのデータベースを
記録した媒体。

【００１１】表３４２に、本発明の全長cDNA（１７３ク
ローン）における5'側と3'側を規定する塩基配列を示す
配列番号と、そのポリヌクレオチドをインサートとして
含む実施例で取得したプラスミドクローンの対応関係を
示す。同一クローンで5'末端配列に対応する3'末端配列
が決定されていないものは空欄とした。5'配列 配列名
の右側が5'配列の配列番号であり、3'配列 配列名の右
側が3'配列の配列番号である。

【００１２】本発明において、ポリヌクレオチドとはDN
AやRNAのようにヌクレオチドが多数重合した分子を意味
する。重合するヌクレオチドの数は特に制限されない。
ポリヌクレオチドの重合度が比較的低い場合には特にオ
リゴヌクレオチドとも表現するが、これも本発明のポリ
ヌクレオチドに含まれる。本発明のポリヌクレオチド、
またはオリゴヌクレオチドは、天然のものであることも
できるし、化学的に合成されたものであることもでき
る。あるいはまた、鋳型となるDNAをもとにPCRのような
酵素的な反応によって合成されたものであっても良い。
更に本発明のポリヌクレオチドは、化学的に修飾された
ものであっても良い。また本発明には、１本鎖ポリヌク
レオチドのみならず、２本鎖ポリヌクレオチドも含まれ
る。本明細書、特に請求項において、単にポリヌクレオ
チドと記載するときには、１本鎖ポリヌクレオチドのみ
ならず２本鎖ポリヌクレオチドをも指すものとする。２
本鎖ポリヌクレオチドを意味するときには、一方の鎖の
みについての塩基配列が記載されることになるが、セン
ス鎖の塩基配列に基づいてその相補鎖の塩基配列は必然
的に規定される。本発明によって提供されるcDNAはいず
れも全長cDNAである。本発明における全長cDNAとは、そ
のcDNAの翻訳開始点となるATGコドンと終止コドンを備
えたcDNAを意味する。したがって、天然のmRNAが蛋白質
コード領域の上流や下流に本来備えている非翻訳領域の
有無は問わない。

【００１３】

【発明の実施の形態】本発明は、表１に示すように配列
番号：２〜配列番号：３３６の偶数番号、ならびに配列
番号：３４２〜配列番号：３５０の偶数番号のアミノ酸
配列のいずれかからなる、ヒト由来の蛋白質を含む。本
発明による１７３種の蛋白質のうち１５６種は、リスト
１.に示すようなcDNAクローンによってコードされてい
る。これらのクローンは、「全長率の高いオリゴキャッ
プ法で作成したヒトcDNAライブラリーから、ATGpr等で
全長cDNAクローンであると判断され、かつ、PSORTでN末
端にシグナル配列が存在する分泌蛋白質、または膜蛋白
質と予測されるクローン」である。

【００１４】以下のリストは、次の情報を順に//で区切
って示している。 クローン名（PSEC番号）、cDNAの長さ、アミノ酸配列の
長さ、5'末端からのATG No.、ATGpr1値、アノテーショ
ンデータのDefinition、アノテーションデータの各デー
タベースにおけるAccession No.、P値、比較配列の長
さ、相同性 GenBank(http://www.ncbi.nlm.nih.gov/Web/Genbank/in
dex.html)やSwissProt(http://www.ebi.ac.uk/ebi_docs
/swissprot_db/swisshome.html)に対するBLAST解析の結
果で明らかな相同性がないクローンについては、アノテ
ーションに関するデータを示さなかった。なお、5'末端
からのATG No.は、5'末端から数えた比較配列の翻訳フ
レームのATGの位置を意味する。つまり、たとえば最初
のATGからの翻訳フレームと比較している場合には1st、
２番目のATGで始まる翻訳アミノ酸配列と比較した場合
には2ndと表す。またP値とは、配列間の類似性を統計的
に起こりうる確率を考慮してスコアで示したもので、一
般に値が小さいと類似性が高い(Altschul, S.F., Gish,
W., Miller, W., Myers, E.W. & Lipman, D.J. (1990)
"Basic local alignment search tool." J. Mol. Bio
l. 215:403-410; Gish,W. & States, D.J. (1993) "Ide
ntification of protein coding regions by database
similarity search." Nature Genet. 3:266-272)。 リスト１. PSEC0001//1992bp//226aa//1st//0.94//GOLGI 4-TRANSM
EMBRANE SPANNING TRANSPORTER MTP (KIAA0108).//Q150
12//3.90E-53//221aa//46% nnnnnnnn//1883bp//326aa//1st//0.94//Homo sapiens d
eath effector domain-containing testicular molecul
e mRNA, complete cds.//AF043733//3.10E-37//852bp//
62% PSEC0005//1366bp//220aa//1st//0.94//Homo sapiens C
LDN6 gene for claudin-6.//AJ249735//5.00E-285//129
5bp//99% PSEC0007//3425bp//570aa//1st//0.94//Homo sapiens F
K506-binding protein (FKBP63) mRNA, partial cds.//
AF089745//0//1580bp//99% PSEC0008//978bp//215aa//1st//0.94//HYPOTHETICAL 7
2.5 KD PROTEIN C2F7.10IN CHROMOSOME I.//Q09701//1.
60E-13//119aa//36% PSEC0012//1499bp//183aa//1st//0.82 PSEC0017//3125bp//273aa//1st//0.33//Mus musculus m
embrane protein TMS-2mRNA, complete cds.//AF181685
//3.00E-303//1949bp//82% PSEC0019//1927bp//339aa//1st//0.9//Homo sapiens NP
D003 mRNA, complete cds.//AF078855//0//1904bp//99% PSEC0020//1483bp//393aa//1st//0.69 PSEC0021//1851bp//116aa//3rd//0.82 PSEC0028//2395bp//348aa//2nd//0.56//VESICULAR INTE
GRAL-MEMBRANE PROTEINVIP36 PRECURSOR (VIP36).//P49
256//9.30E-100//355aa//54% PSEC0029//1683bp//300aa//1st//0.9//OXIDOREDUCTASE
UCPA (EC 1.-.-.-).//P37440//1.00E-21//217aa//32% PSEC0030//1584bp//406aa//1st//0.26 PSEC0031//1336bp//136aa//2nd//0.2 PSEC0035//1729bp//406aa//1st//0.93//NEURONAL OLFAC
TOMEDIN-RELATED ER LOCALIZED PROTEIN PRECURSOR (NO
EL) (1B426B).//Q62609//6.30E-33//373aa//28% PSEC0038//1883bp//223aa//1st//0.9//TRIOSE PHOSPHAT
E/PHOSPHATE TRANSLOCATOR, NON-GREEN PLASTID PRECUR
SOR (CTPT).//P52178//6.60E-13//157aa//33% PSEC0040//2027bp//216aa//2nd//0.82 PSEC0041//2518bp//240aa//2nd//0.51 PSEC0045//1631bp//372aa//1st//0.85 PSEC0048//3707bp//383aa//2nd//0.71//Homo sapiens s
erine protease mRNA, complete cds.//AF015287//0//1
638bp//99% PSEC0049//2652bp//131aa//1st//0.35//Homo sapiens b
rain my047 protein mRNA, complete cds.//AF063605//
0//2651bp//99% PSEC0051//3293bp//227aa//3rd//0.63

【００１５】PSEC0052//3635bp//578aa//2nd//0.94//AQ
UALYSIN I PRECURSOR (EC 3.4.21.-).//P08594//1.60E-
46//348aa//36% PSEC0053//2366bp//285aa//1st//0.94//COLLAGEN ALPHA
1(XII) CHAIN PRECURSOR (FIBROCHIMERIN).//P13944//
1.50E-37//227aa//31% PSEC0055//2147bp//331aa//2nd//0.92//UDP N-ACETYLGL
UCOSAMINE TRANSPORTER(GOLGI UDP-GLCNAC TRANSPORTE
R).//Q00974//4.80E-42//314aa//31% PSEC0059//2863bp//230aa//3rd//0.72//Mus musculus c
laudin-2 mRNA, complete cds.//AF072128//4.50E-127/
/777bp//86% PSEC0061//1931bp//464aa//1st//0.94//BETA-MANNOSYLT
RANSFERASE (EC 2.4.1.-).//P16661//6.00E-42//356aa/
/35% PSEC0068//1717bp//194aa//1st//0.64 PSEC0070//2510bp//286aa//3rd//0.94//OLIGOSACCHARYL
TRANSFERASE STT3 SUBUNIT HOMOLOG.//P46975//2.50E-
99//301aa//63% PSEC0071//3558bp//875aa//1st//0.94//INTER-ALPHA-TR
YPSIN INHIBITOR HEAVYCHAIN H3 PRECURSOR (ITI HEAVY
CHAIN H3) (SERUM-DERIVED HYALURONAN-ASSOCIATED PR
OTEIN) (SHAP).//Q06033//9.30E-141//576aa//37% PSEC0072//2092bp//350aa//1st//0.94//Homo sapiens m
RNA for putative vacuolar proton ATPase membrane s
ector associated protein M8-9.//Y17975//2.10E-133/
/622bp//99% PSEC0073//2341bp//523aa//1st//0.94//UDP-GLUCURONOS
YLTRANSFERASE 2C1 MICROSOMAL (EC 2.4.1.17) (UDPGT)
(FRAGMENT).//P36514//7.90E-71//477aa//36% PSEC0074//2971bp//770aa//1st//0.89//Mus musculus m
RNA for semaphorin W,complete cds.//AB021291//0//2
579bp//85% PSEC0075//2244bp//633aa//2nd//0.79 PSEC0076//3253bp//860aa//1st//0.94//MITOCHONDRIAL
PRECURSOR PROTEINS IMPORT RECEPTOR (72 KD MITOCHON
DRIAL OUTER MEMBRANE PROTEIN) (MITOCHONDRIALIMPORT
RECEPTOR FOR THE ADP/ATP CARRIER) (TRANSLOCASE OF
OUTER MEMBRANETOM70).//P23231//3.80E-11//194aa//2
8% PSEC0077//2195bp//483aa//1st//0.94//TROPONIN T, CA
RDIAC MUSCLE ISOFORMS(TNTC).//P02642//0.00000018//
120aa//28% PSEC0079//1290bp//189aa//2nd//0.94 PSEC0080//3171bp//740aa//2nd//0.94//Homo sapiens m
RNA for NAALADase II protein.//AJ012370//0//3131bp
//99% PSEC0081//2890bp//172aa//1st//0.94 PSEC0082//1878bp//331aa//1st//0.94//PROBABLE OXIDO
REDUCTASE (EC 1.-.-.-).//Q03326//7.30E-30//269aa//
34% PSEC0085//2392bp//280aa//1st//0.85//PROBABLE PROTE
IN DISULFIDE ISOMERASEP5 PRECURSOR (EC 5.3.4.1).//
P38660//5.60E-10//105aa//39% PSEC0086//1821bp//390aa//1st//0.83//CELL SURFACE A
33 ANTIGEN PRECURSOR.//Q99795//2.30E-23//259aa//32
%

【００１６】PSEC0087//1808bp//441aa//1st//0.94//Ho
mo sapiens G protein-coupled receptor mRNA, comple
te cds.//AF181862//5.40E-27//1114bp//60% PSEC0088//2015bp//467aa//1st//0.94//CATHEPSIN B PR
ECURSOR (EC 3.4.22.1).//P07688//1.10E-39//315aa//3
4% PSEC0090//1722bp//543aa//1st//0.92//Homo sapiens h
eparanase (HPA) mRNA,complete cds.//AF144325//0//1
722bp//99% PSEC0094//2291bp//564aa//1st//0.93//PROTEIN PTM1 P
RECURSOR.//P32857//7.10E-15//284aa//28% PSEC0095//2080bp//349aa//1st//0.94 PSEC0098//2185bp//208aa//1st//0.94 PSEC0099//1627bp//350aa//2nd//0.91 PSEC0100//1391bp//172aa//1st//0.77//Homo sapiens c
lone 24952 mRNA sequence, complete cds.//AF131758/
/7.70E-308//1391bp//99% PSEC0101//2547bp//258aa//2nd//0.92 PSEC0104//1430bp//418aa//2nd//0.79 PSEC0105//2506bp//494aa//1st//0.94 PSEC0106//2465bp//326aa//2nd//0.94 PSEC0107//2557bp//130aa//2nd//0.89 PSEC0108//3099bp//267aa//3rd//0.86//HYPOTHETICAL 4
9.3 KD PROTEIN C30D11.06C IN CHROMOSOME I.//Q09906
//9.80E-17//307aa//28% PSEC0109//2563bp//736aa//1st//0.94//Rattus norvegi
cus leprecan (lepre1)mRNA, complete cds.//AF087433
//0//2501bp//84% PSEC0110//2179bp//344aa//1st//0.94 PSEC0111//3362bp//208aa//1st//0.83 PSEC0112//3598bp//349aa//4th//0.74 PSEC0113//2451bp//423aa//1st//0.79//36 KD NUCLEOLA
R PROTEIN HNP36 (DELAYED-EARLY RESPONSE PROTEIN 1
2) (DER12).//Q61672//4.20E-22//169aa//34% PSEC0119//2518bp//555aa//1st//0.87//HYPOTHETICAL 6
3.9 KD PROTEIN C1F12.09 IN CHROMOSOME I.//Q10351//
4.50E-26//240aa//30% PSEC0120//2250bp//302aa//2nd//0.94//Human alpha-1,
3-mannosyl-glycoprotein beta-1, 2-N-acetylglucosam
inyltransferase (MGAT) gene, complete cds.//M61829
//0//2235bp//92% PSEC0121//1666bp//358aa//1st//0.94//HYPOTHETICAL 3
9.9 KD PROTEIN T15H9.1IN CHROMOSOME II PRECURSOR./
/Q10005//4.10E-106//351aa//58% PSEC0124//1686bp//476aa//1st//0.91//VITELLOGENIC C
ARBOXYPEPTIDASE PRECURSOR (EC 3.4.16.-).//P42660//
1.10E-103//444aa//45% PSEC0125//1999bp//256aa//1st//0.74//Homo sapiens m
RNA for type II membrane protein, complete cds, cl
one:HP10328.//AB015630//4.50E-306//1433bp//98% PSEC0126//1906bp//102aa//1st//0.89//Homo sapiens m
RNA for leukotriene B4omega-hydroxylase, complete
cds.//AB002454//3.90E-251//970bp//86%

【００１７】PSEC0127//1773bp//218aa//1st//0.94 PSEC0128//2134bp//306aa//1st//0.94 PSEC0129//1828bp//135aa//1st//0.94 PSEC0130//2934bp//265aa//1st//0.68 PSEC0131//1658bp//297aa//1st//0.94 PSEC0133//2023bp//240aa//1st//0.94 PSEC0134//1898bp//144aa//6th//0.71 PSEC0135//1755bp//322aa//3rd//0.75//Homo sapiens l
ymphatic endothelium-specific hyaluronan receptor
LYVE-1 mRNA, complete cds.//AF118108//0//1640bp//9
9% PSEC0136//1907bp//392aa//1st//0.93 PSEC0137//2981bp//571aa//1st//0.94 PSEC0139//1361bp//218aa//2nd//0.89 PSEC0143//1976bp//125aa//1st//0.74//ENDOSOMAL P24A
PROTEIN PRECURSOR (70KD ENDOMEMBRANE PROTEIN) (PH
EROMONE ALPHA-FACTOR TRANSPORTER) (ACIDIC 24 KD LA
TE ENDOCYTIC INTERMEDIATE COMPONENT).//P32802//1.0
0E-19//129aa//38% PSEC0144//2067bp//247aa//1st//0.94//Homo sapiens C
GI-78 protein mRNA, complete cds.//AF151835//0//19
61bp//99% nnnnnnnn//2807bp//346aa//7th//0.79//PUTATIVE G PRO
TEIN-COUPLED RECEPTORGPR17 (R12).//Q13304//3.00E-4
4//308aa//36% PSEC0147//1964bp//520aa//1st//0.91//HYPOTHETICAL 5
2.8 KD PROTEIN T05E11.5 IN CHROMOSOME IV.//P49049/
/3.60E-19//203aa//38% PSEC0149//1988bp//432aa//1st//0.94 PSEC0150//2259bp//217aa//1st//0.94//Homo sapiens T
-box protein TBX3 (TBX3) mRNA, complete cds.//AF17
0708//2.60E-140//673bp//98% PSEC0151//1688bp//467aa//1st//0.93//TISSUE ALPHA-L
-FUCOSIDASE PRECURSOR(EC 3.2.1.51) (ALPHA-L-FUCOSI
DASE I) (ALPHA-L-FUCOSIDE FUCOHYDROLASE).//P04066/
/5.20E-145//459aa//55% PSEC0152//2130bp//374aa//2nd//0.86 PSEC0158//1836bp//137aa//4th//0.94//Homo sapiens l
ifeguard (LFG) mRNA, complete cds.//AF190461//2.50
E-44//591bp//68% PSEC0159//2198bp//372aa//1st//0.8//Homo sapiens mR
NA for type II membrane protein, complete cds, clo
ne:HP10328.//AB015630//0//2186bp//99% PSEC0161//2222bp//496aa//1st//0.89//GLUCOSE TRANSP
ORTER TYPE 5, SMALL INTESTINE (FRUCTOSE TRANSPORTE
R).//P22732//8.10E-101//479aa//42% PSEC0162//1320bp//271aa//1st//0.83 PSEC0163//2167bp//578aa//1st//0.94//HYPOTHETICAL 6
7.8 KD PROTEIN IN IKI1-ERG9 INTERGENIC REGION.//P3
8875//3.10E-48//228aa//36% PSEC0164//1877bp//463aa//1st//0.93//GLIOMA PATHOGE
NESIS-RELATED PROTEIN(RTVP-1 PROTEIN).//P48060//1.
80E-27//169aa//39% PSEC0165//2111bp//242aa//1st//0.83 PSEC0167//874bp//103aa//7th//0.73

【００１８】PSEC0168//2533bp//269aa//1st//0.94//HY
POTHETICAL 42.5 KD PROTEIN IN TSM1-ARE1 INTERGENIC
REGION.//P25625//2.50E-18//179aa//30% PSEC0169//1792bp//204aa//1st//0.75//Homo sapiens t
ransmembrane 4 superfamily protein mRNA, complete
cds.//AF100759//0//1771bp//99% PSEC0170//2622bp//353aa//1st//0.94//Homo sapiens E
2IG4 (E2IG4) mRNA, complete cds.//AF191019//0//254
2bp//99% PSEC0171//2005bp//301aa//2nd//0.91 PSEC0172//2012bp//415aa//1st//0.92//Homo sapiens p
rocollagen C-terminalproteinase enhancer protein 2
(PCOLCE2) mRNA, complete cds.//AF098269//0//1741b
p//99% PSEC0173//1740bp//406aa//1st//0.91//NEURONAL OLFAC
TOMEDIN-RELATED ER LOCALIZED PROTEIN PRECURSOR (NO
EL) (1B426B).//Q62609//6.60E-33//373aa//28%PSEC017
8//2308bp//222aa//3rd//0.94 PSEC0181//1890bp//165aa//3rd//0.66 PSEC0182//2153bp//657aa//2nd//0.82//Homo sapiens m
RNA for UDP-GalNAc:polypeptide N-acetylgalactosami
nyltransferase 7.//AJ002744//0//2006bp//99%PSEC018
3//2031bp//451aa//1st//0.88//CARTILAGE MATRIX PROT
EIN PRECURSOR (MATRILIN-1).//P05099//5.50E-63//228
aa//54% PSEC0190//1841bp//194aa//1st//0.87 PSEC0191//1493bp//472aa//1st//0.87//ELASTIN PRECUR
SOR (TROPOELASTIN).//P15502//5.00E-113//367aa//67% PSEC0192//1557bp//153aa//1st//0.93 PSEC0197//3555bp//576aa//2nd//0.85//PEROXISOMAL-CO
ENZYME A SYNTHETASE (EC 6.-.-.-).//P38137//1.30E-3
3//169aa//32% PSEC0198//2083bp//343aa//1st//0.94 PSEC0199//2586bp//283aa//1st//0.94 PSEC0200//1548bp//443aa//1st//0.94//Mus musculus i
mmunosuperfamily protein Bl2 mRNA, complete cds.//
AF061260//4.30E-243//1297bp//89% PSEC0203//1457bp//323aa//1st//0.87 PSEC0204//1484bp//142aa//1st//0.74 PSEC0205//1656bp//435aa//1st//0.94//CELL DIVISION
CONTROL PROTEIN 91.//P41733//7.70E-41//290aa//33% PSEC0207//1754bp//262aa//3rd//0.94//Homo sapiens m
ultispanning nuclear envelope membrane protein nur
im (NRM29) mRNA, partial cds.//AF143676//0.00E+00/
/1399bp//99% PSEC0209//2144bp//186aa//1st//0.93//Homo sapiens P
ancreas-specific TSA305 mRNA , complete cds.//AB02
0335//0//1770bp//99%

【００１９】PSEC0210//1689bp//349aa//1st//0.71 PSEC0213//1824bp//323aa//1st//0.94 PSEC0214//1959bp//141aa//1st//0.94 PSEC0215//2112bp//551aa//2nd//0.94//Homo sapiens e
milin precursor, mRNA,complete cds and 3' UTR.//AF
088916//0//1470bp//98% PSEC0216//1765bp//410aa//2nd//0.89 PSEC0218//1369bp//242aa//1st//0.69//Homo sapiens t
orsinA (DYT1) mRNA, complete cds.//AF007871//3.10E
-26//619bp//61% PSEC0220//1584bp//365aa//1st//0.94//Mouse Wnt-6 mR
NA, complete cds.//M89800//5.50E-198//1310bp//82% PSEC0222//899bp//139aa//2nd//0.94 PSEC0223//1874bp//221aa//1st//0.94 PSEC0224//1463bp//170aa//1st//0.89//UROMODULIN PRE
CURSOR (TAMM-HORSFALLURINARY GLYCOPROTEIN) (THP)./
/P48733//8.30E-10//141aa//36% PSEC0226//2103bp//477aa//1st//0.94//Mus musculus c
arboxypeptidase X2 mRNA, complete cds.//AF017639//
1.00E-114//1057bp//66% PSEC0227//1410bp//379aa//2nd//0.81//Cricetulus gri
seus SREBP cleavage activating protein (SCAP) mRN
A, complete cds.//U67060//2.50E-231//1099bp//84% PSEC0228//1483bp//146aa//1st//0.92//COP-COATED VES
ICLE MEMBRANE PROTEINP24 PRECURSOR (P24A) (RNP21.
4).//Q63524//5.90E-21//110aa//32% PSEC0230//1784bp//271aa//1st//0.76//SIGNAL RECOGNI
TION PARTICLE RECEPTORBETA SUBUNIT (SR-BETA).//P47
758//5.80E-123//271aa//90% PSEC0232//1709bp//246aa//1st//0.75//30 KD ADIPOCYT
E COMPLEMENT-RELATED PROTEIN PRECURSOR (ACRP30) (A
DIPOCYTE SPECIFIC PROTEIN ADIPOQ).//Q60994//3.30E-
24//242aa//32% PSEC0233//2499bp//267aa//1st//0.82 PSEC0235//1601bp//211aa//1st//0.94 PSEC0236//1906bp//529aa//1st//0.94//LAMININ GAMMA-
1 CHAIN PRECURSOR (LAMININ B2 CHAIN).//P11047//5.0
0E-181//472aa//62% PSEC0240//1638bp//253aa//1st//0.94//WNT-11 PROTEIN
PRECURSOR.//O96014//3.40E-109//220aa//93%

【００２０】PSEC0241//3593bp//622aa//1st//0.85//Ho
mo sapiens cerebral cell adhesionmolecule mRNA, co
mplete cds.//AF177203//2.50E-121//1541bp//68% PSEC0243//2835bp//743aa//3rd//0.77 PSEC0244//2063bp//287aa//1st//0.91 PSEC0245//2896bp//418aa//3rd//0.91//INTEGRAL MEMBR
ANE GLYCOPROTEIN GP210PRECURSOR.//P11654//3.40E-20
5//483aa//78% PSEC0246//2969bp//345aa//1st//0.94//LOW-DENSITY LI
POPROTEIN RECEPTOR-RELATED PROTEIN 2 PRECURSOR (ME
GALIN) (GLYCOPROTEIN 330).//P98158//1.60E-22//126a
a//42% PSEC0247//2872bp//236aa//1st//0.94//PLATELET-ENDOT
HELIAL TETRASPAN ANTIGEN 3 (PETA-3) (GP27) (MEMBRA
NE GLYCOPROTEIN SFA-1) (CD151 ANTIGEN).//O35566//
3.30E-28//237aa//29% PSEC0248//2694bp//172aa//1st//0.84 PSEC0249//3320bp//534aa//1st//0.94//BUTYROPHILIN P
RECURSOR (BT).//Q62556//1.10E-21//276aa//32% PSEC0250//2179bp//223aa//2nd//0.74//TWISTED GASTRU
LATION PROTEIN PRECURSOR.//P54356//1.50E-34//231aa
//35% PSEC0252//2617bp//491aa//3rd//0.89//HYPOTHETICAL 5
6.2 KD PROTEIN IN ERG8-UBP8 INTERGENIC REGION.//Q0
4991//2.40E-15//208aa//29% PSEC0253//2872bp//265aa//1st//0.69//PHOSPHATIDYLIN
OSITOL-4-PHOSPHATE 5-KINASE TYPE II ALPHA (EC 2.7.
1.68) (PIP5KII-ALPHA) (1-PHOSPHATIDYLINOSITOL-4-PH
OSPHATE KINASE) (PTDINS(4)P-5-KINASE B ISOFORM) (D
IPHOSPHOINOSITIDE KINASE).//O70172//1.30E-139//240
aa//62% PSEC0255//3774bp//687aa//2nd//0.89//Homo sapiens m
RNA for TM7XN1 protein.//AJ011001//0//3700bp//99% PSEC0258//3791bp//349aa//1st//0.94 PSEC0259//2583bp//242aa//2nd//0.89//CYTOCHROME B56
1 (CYTOCHROME B-561).//Q95245//3.70E-44//211aa//47
% PSEC0260//2492bp//496aa//1st//0.94 PSEC0261//3080bp//806aa//2nd//0.76//MITOCHONDRIAL
PRECURSOR PROTEINS IMPORT RECEPTOR (72 KD MITOCHON
DRIAL OUTER MEMBRANE PROTEIN) (MITOCHONDRIALIMPORT
RECEPTOR FOR THE ADP/ATP CARRIER) (TRANSLOCASE OF
OUTER MEMBRANETOM70).//P23231//4.60E-07//175aa//2
3% PSEC0263//4144bp//971aa//2nd//0.94 PSEC0084//2788bp//335aa//1st//0.86//IMPLANTATION-A
SSOCIATED PROTEIN.//O35777//1.80E-167//335aa//92% PSEC0237//1419bp//248aa//1st//0.81//Homo sapiens C
TG4a mRNA, complete cds.//U80744//8.30E-22//556bp/
/61% PSEC0264//2617bp//157aa//1st//0.94 PSEC0265//2646bp//192aa//1st//0.76

【００２１】（注１） ATGpr1の値がやや低いクローン
（PSEC0017, ATGpr1 0.33; PSEC0030,ATGpr1 0.26; PSE
C0031, ATGpr1 0.20; PSEC0049, ATGpr1 0.35）： これ
らのクローンは、5'-端配列データをATGprで選別はして
おらず、5'-端配列データからシグナル配列をもち、か
つ、5'-端配列データでのORFの長いものとして選別して
きたクローンを全長cDNA配列解析したものである。これ
らはすべてN-末端にシグナル配列が存在していた。ま
た、以上４クローンのうちPSEC0049以外のものは、公知
のESTとの比較の結果cDNAの5'末端側に公知のESTには含
まれない部分を持っていた。またPSEC0049は、公知のES
Tと比較してcDNAのORFにおいて5'末端側にESTに含まれ
ていない部分を持っていた。つまり、これらのクローン
がいずれも全長cDNAであることが明らかである。

【００２２】一方、本発明による１７３種の蛋白質のう
ち次の１５種は、リスト２.に示すようなcDNAクローン
（PSEC0027, PSEC0047, PSEC0066, nnnnnnnn, PSEC006
9, PSEC0078, PSEC0092, PSEC0103, PSEC0117, PSEC014
2, PSEC0212, PSEC0239, PSEC0242, PSEC0251, PSEC025
6）によってコードされている。これらのクローンは、
5'-端配列データ（one pass sequencing）からは分泌蛋
白質、または膜蛋白質と予測されながら、全長cDNA配列
をPSORTで解析した結果は、N-末端にシグナル配列が存
在しなかった。しかし、全長配列からMEMSAT [D. T. Jo
nes, W. R. Taylor & J. M. Thornton, Biochemistry,
33: 3038-3049 (1994)]での解析により膜蛋白質（trans
membrane helixをもつ）であると予測された。同様にこ
れら全てのクローンがSOSUI[T.Hirokawa et.al. Bioinf
ormatics, 14,378-379(1998)]（三井情報開発株式会社
販売）でも膜蛋白質であると予測された。すなわち、
「全長率の高いオリゴキャップ法で作成したヒトcDNAラ
イブラリーから、ATGpr等で全長cDNAクローンであると
判断され、かつ、MEMSATとSOSUIで膜蛋白質と予測され
るクローン」であった。これらのクローンによってコー
ドされる蛋白質も上記分泌蛋白質、または膜蛋白質のカ
テゴリーに入れることができる。なおこれら１５クロー
ンのうちで２クローン（PSEC0242とPSEC0251）は、N-末
端にシグナル配列をもたない膜蛋白質と予測された。し
かし、いずれのクローンも3番目のATG（ともにATGpr1の
値が高い）から翻訳がはじまると仮定するとN-末端にシ
グナル配列が存在する。このため、これらの２クローン
については、N-末端にシグナル配列が存在する分泌蛋白
質、または膜蛋白質のカテゴリーに入る可能性もある。

【００２３】以下のリストは、次の情報を順に//で区切
って示している。 クローン名（PSEC番号）、cDNAの長さ、アミノ酸配列の
長さ、5'末端からのATG No.、ATGpr1値、PSORTによるシ
グナル配列の予測結果、MEMSATとSOSUIによる膜蛋白質
の予測結果、アノテーションデータのDefinition、アノ
テーションデータの各データベースにおけるAccession
No.、P値、比較配列の長さ、相同性 GenBank(http://www.ncbi.nlm.nih.gov/Web/Genbank/in
dex.html)やSwissProt(http://www.ebi.ac.uk/ebi_docs
/swissprot_db/swisshome.html)に対するBLAST解析の結
果で明らかな相同性がないクローンについては、アノテ
ーションに関するデータを示さなかった。 リスト２. PSEC0027//1085bp//271aa//1st//0.94//No //transmemb
rane PSEC0047//2048bp//267aa//1st//0.94//No //transmemb
rane//INTEGRAL MEMBRANE PROTEIN 2B (TRANSMEMBRANE
PROTEIN E3-16).//O42204//1.80E-55//264aa//44% PSEC0092//3624bp//465aa//1st//0.94//No //transmemb
rane//Homo sapiens mRNA for heparan-sulfate 6-sulf
otransferase, complete cds.//AB006179//2.70E-102//
1057bp//71% PSEC0066//2682bp//474aa//1st//0.79//No //transmemb
rane//TETRACYCLINE RESISTANCE PROTEIN, CLASS E (TE
TA(E)).//Q07282//7.50E-19//173aa//31% nnnnnnnn//2405bp//730aa//1st//0.26//No //transmemb
rane//VERY-LONG-CHAINACYL-COA SYNTHETASE (EC 6.2.
1.-) (VERY-LONG-CHAIN- FATTY-ACID-COA LIGASE).//O3
5488//2.50E-140//520aa//45% PSEC0069//2568bp//433aa//2nd//0.94//No //transmemb
rane PSEC0103//2530bp//236aa//1st//0.94//No //transmemb
rane//Homo sapiens neuroendocrine-specific protein
-like protein 1 (NSPL1) mRNA, complete cds.//AF119
297//0//2524bp//99% PSEC0117//1873bp//583aa//1st//0.94//No //transmemb
rane//Rattus norvegicus lipolysis-stimulated remna
nt receptor beta subunit mRNA, complete cds.//AF11
9669//2.00E-221//1048bp//76% PSEC0142//2153bp//343aa//2nd//0.94//No //transmemb
rane//PROBABLE G PROTEIN-COUPLED RECEPTOR RTA.//P2
3749//1.20E-159//343aa//84% PSEC0212//1677bp//111aa//1st//0.94//No //transmemb
rane//Homo sapiens NJAC protein (NJAC) mRNA, compl
ete cds.//AF144103//1.40E-237//1303bp//91% PSEC0239//1712bp//423aa//2nd//0.18//No //transmemb
rane//Homo sapiens aspartyl protease mRNA, complet
e cds.//AF050171//0//1712bp//93% PSEC0242//3017bp//401aa//1st//0.9//No //transmembr
ane PSEC0251//2372bp//393aa//1st//0.78//No //transmemb
rane PSEC0256//3520bp//612aa//1st//0.89//No //transmemb
rane//Homo sapiens protocadherin alpha 12 (PCDH-al
pha12) mRNA, complete cds.//AF152308//0//3520bp//9
9% PSEC0078//2194bp//333aa//2nd//0.24//No//transmembr
ane//M-Sema F=a factorin neural network developmen
t [mice, neonatal brain, mRNA, 3503 nt].//S79463//
1.50E-282//1945bp//83% （注1） ATGpr1の値がやや低いクローン（PSEC0239, AT
Gpr1 0.18）：PSEC0239は、5'-端配列データからATGpr1
の値が高く、かつMEMSATとSOSUIで膜蛋白質（transmemb
rane helixをもつ）であると予測されたクローンであ
る。また、該当クローンについてESTとの比較をした結
果、公知のESTに対してcDNAの5'-端側にESTには含まれ
ない部分を持つと判定された。 （注2）PSEC0242とPSEC0251：両クローンは3番目のATG
から翻訳がはじまるとすると「N-末端にシグナル配列が
存在」のカテゴリーに入る。 PSEC0242: No.3 ATG, ATGpr1 0.82, SP-Yes, ORF 171-1
343, 391 aa, Signal peptide 24aa; PSEC0251: No.3 ATG, ATGpr1 0.77, SP-Yes, ORF 116-1
256, 380 aa, Signal peptide 28aa. ここでSP-Yesとは、PSORTによる予測でN末端シグナル配
列が存在することを意味する。 （注3） PSEC0078のATGpr1の値は、0.24であったが、5'
-端配列データからATGpr1の値が高く、かつMEMSATとSOS
UIで膜蛋白質（transmembrane helixをもつ）であると
予測された。また、ESTとの比較をした結果、cDNAの5'-
端が50bp以上短くて、ESTに対して非全長クローンであ
ると判定されるものはなかった。

【００２４】更に本発明による１７３種の蛋白質のうち
残る２種は、リスト３.に示すcDNAクローン（PSEC019
5、および PSEC0206)によってコードされている。Swiss
Protとの相同性より、PSEC0195はmouse plasma membran
e adaptor HA2/AP2 adaptinalpha C subunitと、PSEC02
06は分泌顆粒に存在するhuman carboxypeptidase Hprec
ursor (prohormone processing carboxypeptidase)に比
較的高い相同性が見られた。したがって、これらの蛋白
質は、分泌蛋白質あるいは膜蛋白質のカテゴリーに入
る。

【００２５】リスト３.以下のリストは、次の情報を順
に//で区切って示している。 クローン名（PSEC番号）、cDNAの長さ、アミノ酸配列の
長さ、5'末端からのATG No.、ATGpr1値、PSORTによるシ
グナル配列の予測結果、MEMSATとSOSUIによる膜蛋白質
の予測結果、アノテーションデータのDefinition、アノ
テーションデータの各データベースにおけるAccession
No.、P値、比較配列の長さ、相同性 PSEC0195//1979bp//467aa//2nd//0.80//No//No//ALPHA-
ADAPTIN C (CLATHRIN ASSEMBLY PROTEIN COMPLEX 2 ALP
HA-C LARGE CHAIN) (100 KD COATED VESICLE PROTEIN
C) (PLASMA MEMBRANE ADAPTOR HA2/AP2 ADAPTIN ALPHA
C SUBUNIT).//P17427//1.8E-144//281aa//98% PSEC0206//1606bp//430aa//3rd//0.90//No//No//CARBOX
YPEPTIDASE H PRECURSOR(EC 3.4.17.10) (CPH) (CARBOX
YPEPTIDASE E) (CPE) (ENKEPHALIN CONVERTASE)(PROHOR
MONE PROCESSING CARBOXYPEPTIDASE).//P15087//1.8E-1
03//397aa//49%

【００２６】本発明の分泌蛋白質、あるいは膜蛋白質
は、そのアミノ酸配列が明らかとなっていることから、
適当な発現系を適用して組み換え体として発現させるこ
とにより、あるいは、そのタンパクを特異的に認識する
抗体を用いることで、その生物学的活性を解析すること
が可能である。分泌蛋白質、あるいは膜蛋白質は、例え
ば「The Practical Approach Series」(IRL PRESS社)の
『Glycobiology』(M.Fukuda, A.Kobata編、1993)、『Gr
owthFactors』(I.McKay, I.Leigh編、1993)、『Extrace
llular Matrix』(M.A.Haralson, J.R.Hassell編、199
5)、または、「Method in Molecular Biology」(Humana
Press社)シリーズの『Glycoprotein Analysis in Biome
dicine』(Elizabeth F.Hounsell編、1993)にもとづい
て、それぞれの蛋白質の生物学的活性の解析が可能であ
る。あるいは「日本生化学会編 新生化学実験講座7 増
殖分化因子とその受容体」（1991年発行）東京化学同人
社や「Methods in Enzymology」 AcademicPress社のVol
ume 296 Neurotranmitter Transporters, Volume 294 I
on Channels (Part C), Volume 293 Ion Channels (Par
t B), Volume 292 ABC Transporters, Volume 288 Chem
okine Receptors, Volume 287 Chemokines, Volume 248
Proteolytic Enzymes, Volume 245 Extracellular Mat
rix Components, Volume 244 Proteolytic Enzymes, Vo
lume 230 Guide to Techniques in Glycobiology, Volu
me 198 Peptide Growth Factors, Volume 192 Biomembr
anes, Volume 191 Biomembranes, Volume 149 Drug and
Enzyme Targeting等の開示に基づいて、分泌蛋白質や
膜蛋白質に関連する生物学的活性を解析することもでき
る。分泌蛋白質や膜蛋白質について、Online Mendelian
Inheritance in Man (OMIM)(http://www.ncbi.nlm.ni
h.gov/Omim/)を利用し、下記検索キーワードを用いて検
索すると、各キーワードにおいて、多くの疾患に関連し
た以下に示す結果が得られた。あるいは、例えば、この
ように、分泌蛋白質や膜蛋白質は疾患に関与することが
多く、医療産業上の標的分子として、有用なことが分か
る。なおOMIMには常に新しい情報が付加されている。し
たがって当業者は、特定の疾患と本発明の遺伝子との新
たな関係を最新のデータベースから見出すことができ
る。OMIM検索に用いたキーワード (1) secretion protein（分泌蛋白質） (2) membrane protein,（膜蛋白質） 検索結果には、OMIM登録番号のみを記載した。この番号
をもとにOMIMで疾患と遺伝子や蛋白質との関係を示すデ
ータを見ることができる。また、OMIMデータは日々更新
されている。

【００２７】１） Secretion protein（分泌蛋白質） 268 entries found, searching for "secretion protei
n" 104760, 176860, 160900, 107400, 118910, 139320, 60
3850, 147572, 176880,600946, 603215, 157147, 60017
4, 151675, 170280, 179512, 179513, 138120,179509,
246700, 179510, 600626, 179511, 600998, 109270, 60
1489, 154545,179490, 185860, 603216, 122559, 60174
6, 147290, 602672, 146770, 603062,179508, 131230,
601591, 602421, 139250, 167805, 167770, 600041, 60
0564,118825, 601146, 300090, 600753, 601652, 60075
9, 600768, 602434, 182590,603166, 308230, 602534,
603489, 107470, 150390, 104610, 173120, 158106,143
890, 306900, 308700, 134797, 137350, 227500, 17630
0, 107730, 600760,138079, 120180, 120160, 120150,
124092, 138160, 101000, 227600, 600509,601199, 142
410, 104311, 193400, 201910, 107300, 122560, 27280
0, 217000,590050, 147670, 133170, 176730, 300300,
134370, 274600, 120140, 162151,158070, 152790, 120
120, 106100, 300200, 192340, 190160, 138040, 14747
0,147620, 173350, 147380, 152200, 152760, 157145,
153450, 264080, 113811,600937, 600840, 188545, 202
110, 600514, 186590, 603372, 136435, 137241,25280
0, 214500, 207750, 138850, 139191, 142640, 138130,
189907, 603692,600633, 603355, 107270, 600377, 14
7892, 232200, 600281, 232800, 602358,137035, 60177
1, 601769, 253200, 601933, 118444, 600270, 120700,
600945,603732, 147660, 600761, 172400, 600823, 60
0877, 130080, 171060, 107740,307800, 602843, 13066
0, 152780, 124020, 601124, 601340, 601604, 601610,
171050, 312060, 232700, 300159, 142703, 600734, 12
5255, 168450, 123812,188540, 147940, 188450, 60083
9, 182452, 188400, 182280, 176760, 263200,600264,
188826, 252650, 601185, 162641, 137216, 601398, 60
1538, 118888,118445, 601745, 190180, 601922, 18209
8, 602008, 147440, 602384, 600031,109160, 602663,
151670, 602682, 602730, 602779, 146880, 603061, 14
2704,603140, 106150, 600732, 153620, 603318, 13939
2, 600042, 102200, 603493,182100, 264300, 603795,
184600

【００２８】２） Membrane protein（膜蛋白質） 1017 entries found, searching for "membrane protei
n" 130500, 305360, 153330, 173610, 170995, 109270, 17
0993, 309060, 120920,602333, 133740, 133710, 60269
0, 133730, 159430, 600897, 133090, 601178,602413,
602003, 109280, 603237, 602173, 107776, 602334, 12
5305, 602335,182879, 154045, 309845, 600594, 60371
8, 603241, 603214, 603657, 603177,600182, 601476,
602879, 136950, 600723, 601114, 185880, 185881, 30
0096,602257, 160900, 177070, 603062, 603344, 60297
7, 310200, 600959, 300100,186945, 600039, 600267,
128240, 182900, 601097, 136430, 600946, 602534,601
047, 143450, 603141, 603700, 600579, 256540, 15944
0, 602414, 600403,602048, 188860, 137290, 158343,
184756, 602910, 603179, 600279, 108733,107770, 173
335, 602625, 154050, 219800, 603850, 601028, 60044
7, 104225,186946, 601767, 603143, 121015, 603215,
227400, 603735, 600179, 602421,180721,

【００２９】176801, 176860, 600753, 603142, 17679
0, 600266, 601239, 115501, 143890,121014, 121011,
125950, 603534, 304040, 601134, 600754, 601510, 60
1595,190315, 300172, 602216, 602261, 602262, 60246
1, 131560, 179514, 179512,176981, 142461, 139310,
312080, 176640, 128239, 185470, 310300, 601403,601
757, 273800, 151460, 176943, 104311, 168468, 12013
0, 602887, 600164,601531, 601832, 104775, 600040,
603583, 176894, 602631, 166945, 182180,120620, 141
180, 601014, 139150, 182860, 177061, 600174, 18006
9, 191275,104760, 601693, 300017, 603518, 601009,
134651, 601107, 603868, 600168,136425, 603531, 603
291, 600917, 603216, 102720, 300118, 179590, 13563
0,602285, 107450, 602296, 303630, 176878, 120090,
600322, 138160, 601212,603293, 131230, 112205, 600
763, 600718, 300187, 170715, 601966, 300051,60247
4,

【００３０】120070, 600691, 600855, 182309, 60210
1, 602857, 194355, 162230, 600874,113730, 155550,
602701, 306400, 601789, 231200, 107271, 175100, 18
2870,305100, 301000, 601313, 157147, 147670, 13920
0, 603593, 157655, 600934,155970, 602049, 155960,
155760, 118990, 135620, 308230, 602694, 162060,300
023, 160993, 153619, 153432, 120131, 603823, 60316
7, 601023, 600816,165040, 601681, 166490, 300112,
120190, 300145, 163970, 600772, 602926,602933, 602
202, 400015, 151510, 600759, 602672, 602654, 60382
1, 116952,151430, 602632, 155975, 602217, 150370,
600752, 601179, 600932, 603048,603234, 601805, 603
822, 603869, 601717, 601181, 313440, 139130, 10777
7,109190, 603452, 191163, 191164, 602370, 176877,
103195, 600523, 191328,601275, 204200, 602426, 603
820, 600551, 600695, 600552, 600553, 602306,60152
3,

【００３１】602507, 602299, 600583, 114070, 60063
2, 603498, 185430, 600587, 235200,173470, 603199,
601633, 602500, 208900, 180297, 156225, 516020, 19
0195,141900, 102680, 193300, 101000, 193400, 30001
1, 107400, 257220, 107741,180380, 203200, 111700,
600024, 304800, 600065, 110750, 179605, 113705,601
638, 222900, 120120, 602509, 602469, 600930, 60138
3, 176261, 602574,602997, 311770, 131550, 603616,
308700, 603372, 256100, 224100, 276903,305900, 516
000, 131195, 314555, 601567, 603866, 306900, 10339
0, 186720,173850, 601050, 602505, 186590, 246530,
602689, 194380, 300041, 162643,152790, 120150, 600
682, 600106, 272750, 188040, 602382, 601497, 11381
1,182138, 212138, 601309, 109690, 114760, 176805,
601253, 123900, 602581,189980, 191190, 110700, 600
163, 137167, 600580, 601610, 190000, 123825,60349
1,

【００３２】600135, 186591, 173910, 138140, 10726
6, 120950, 601081, 603690, 244400,312700, 171060,
601199, 601758, 170500, 277900, 601997, 314850, 60
1880,603009, 120220, 603126, 164920, 602934, 16473
0, 163890, 603434, 107269,602909, 600877, 256550,
164761, 602872, 120110, 126150, 158070, 266200,223
360, 250800, 269920, 252650, 603355, 154582, 13819
0, 300035, 602640,227650, 158120, 153700, 182380,
155740, 204500, 603401, 601975, 300135,136350, 602
924, 300167, 185050, 176100, 300189, 151525, 30020
0, 165180,230800, 602158, 602676, 603411, 193245,
120325, 601848, 192500, 603102,147795, 245900, 137
060, 147557, 120650, 602377, 307800, 120930, 30810
0,142800, 191092, 232300, 173510, 602225, 180470,
190930, 186357, 134638,600544, 601373, 600509, 600
359, 603784, 600395, 600653, 603754, 601597,60106
6,

【００３３】600185, 601295, 600978, 205400, 60327
4, 600418, 600839, 516050, 601691,601007, 600650,
600308, 603261, 601193, 600004, 600017, 516040, 25
3800,276901, 600019, 257200, 108780, 300037, 30010
4, 300126, 255125, 203300,300191, 426000, 302060,
304700, 201475, 252010, 193210, 311030, 306250,248
600, 191740, 108360, 131244, 600423, 232200, 19130
5, 231680, 103320,190180, 600493, 111200, 226200,
312600, 600170, 111680, 186910, 203100,600536, 600
238, 186830, 186760, 186745, 186711, 106180, 11220
3, 103180,182530, 182160, 600644, 307030, 192321,
600667, 125647, 179080, 114207,114860, 176000, 116
930, 600748, 173515, 173325, 600377, 171760, 17105
0,118425, 170260, 191315, 600798, 600821, 600823,
600444, 600840, 159465,600857, 158380, 600867, 154
360, 152427, 150330, 110900, 147840, 147360,14728
0,

【００３４】146880, 312610, 120940, 142871, 14279
0, 600937, 142600, 134390, 111250,600979, 600997,
142460, 186845, 134635, 601017, 139191, 139090, 13
8850,601040, 138720, 122561, 131100, 123610, 21707
0, 100500, 603377, 602354,603302, 603207, 603086,
602188, 602095, 603867, 603842, 603798, 602602,601
194, 602607, 603713, 603681, 601252, 603648, 60364
6, 603644, 601282,601284, 603667, 603712, 603594,
601872, 603425, 601843, 603263, 603208,601411, 603
201, 603189, 601463, 603164, 603152, 603087, 60287
4, 601492,602893, 602057, 602859, 602746, 603879,
603510, 602458, 603380, 601581,603765, 603283, 601
599, 601733, 601852, 602316, 601615, 601617, 60218
4,602894, 603005, 603030, 603861, 602835, 602136,
600153, 600074, 600046,600023, 601625, 516006, 600
018, 600016, 516002, 601590, 313475, 313470,60024
4,

【００３５】600528, 601611, 600282, 600327, 60156
8, 600368, 601730, 601535, 601745,601929, 300169,
300150, 300132, 601533, 600385, 600464, 600424, 60
0429,601756, 601488, 516005, 251100, 516004, 60091
8, 516003, 602192, 516001,240500, 600465, 602241,
602243, 230200, 601485, 601478, 601416, 602297,601
459, 601839, 602314, 193065, 193001, 191306, 60050
4, 601020, 191191,602372, 190181, 600534, 188380,
186854, 186360, 600530, 185250, 182331,600535, 182
305, 601296, 600582, 600732, 600734, 600742, 60078
2, 176802,176266, 600769, 601883, 600864, 601901,
176260, 173490, 600910, 601905,171890, 600916, 601
987, 602679, 162651, 161555, 160994, 602714, 60271
5,602724, 602736, 300007, 602783, 275630, 602836,
270200, 602871, 159460,602876, 154540, 153900, 602
890, 601153, 602190, 602905, 153634, 153337,60291
4,

【００３６】152310, 151690, 151625, 602935, 60297
4, 150325, 602992, 150320, 250790,603006, 603007,
603008, 150292, 233690, 603046, 150210, 603061, 14
7940,603063, 221770, 223100, 603097, 147880, 60311
8, 147730, 146928, 146630,142622, 603149, 603150,
603151, 600923, 138981, 138590, 138330, 216950,603
192, 138297, 603202, 601002, 602343, 138230, 13613
1, 603217, 603220,134660, 131390, 131235, 603242,
603243, 130130, 602345, 126455, 601123,126064, 125
240, 602359, 603312, 602380, 603318, 123890, 12383
6, 603356,603361, 603366, 123830, 179610, 188060,
123620, 120980, 186355, 118510,114835, 114217, 113
810, 603499, 182310, 111740, 109610, 603548, 60356
4,108740, 603598, 603613, 107273, 603626, 602518,
179410, 603647, 602515,603652, 106195, 602573, 178
990, 105210, 104615, 167055, 603717, 104614,60372
8,104210, 603749, 603750, 103850, 602608, 603787,
603788, 603796, 173445,103220, 102910, 102681, 102
670, 102642, 603833, 173391, 102576, 102575,17183
3, 102573, 101800, 603875, 601108 疾患に関連した遺伝子を調べる方法として病態組織と正
常組織において遺伝子発現量の違いを調べる発現頻度解
析がある。発現頻度解析には、ノーザンハイブリダイゼ
ーションやディファレンシャルディスプレイなどの他に
も高密度cDNAフィルターやDNAマイクロアレイ、またはP
CR法などを用いた発現頻度解析がある(実験医学 Vol.1
7, No.8, 980-1056 (1999)、村松・那波監修 細胞工学
別冊「DNAマイクロアレイと最新PCR法」(秀潤社))。こ
れらの解析法により、病態組織と正常組織において遺伝
子発現量の違いを調べた結果から発現量の違いが明らか
な遺伝子は、その疾患に関連した遺伝子といえる。ま
た、病態組織でなくとも、病態に関連した特異的な現象
を再現させた培養細胞と正常細胞において遺伝子発現量
の違いを調べた結果から発現量の違いが明らかな遺伝子
は、その疾患に関連した遺伝子といえる。次に、顕著な
細胞変化(分化、アポトーシスなど)の際に発現量が明ら
かに変動する遺伝子は、その細胞機能に関連した重要な
遺伝子であり、疾患の候補遺伝子となる。さらには、組
織特異的な発現を示す遺伝子はその組織内で重要な役割
を担う遺伝子であり、その組織が関連した疾患の候補遺
伝子の可能性がある。例えば、非酵素的蛋白糖化反応は
各種糖尿病慢性合併症の原因とされている。したがって
糖化蛋白質特異的に発現の上昇または減少する遺伝子
は、糖化蛋白質による糖尿病合併症に関する遺伝子であ
る(Diabetes 1996, 45(Suppl.3), S67-S72、 Diabetes
1997, 46(Suppl.2), S19-S25)。また、慢性関節リュウ
マチの成因には、関節腔の内面を覆っている滑膜細胞の
増殖や、関節滑膜組織に浸潤した白血球が産生するサイ
トカインの作用による炎症反応が関係していると考えら
れている（リュウマチ情報センター、http://www.rheum
a-net.or.jp/）。最近の研究によれば、tissue necrosi
s factor (TNF) -alfaが関与することがわかっている
（Current opinion in immunology 1999, 11:657-66
2）。したがってTNFが滑膜細胞に作用して発現変化する
遺伝子は、リュウマチに関すると考えられる。さらに、
神経細胞の分化に関する遺伝子は、神経疾患の原因遺伝
子の候補であるとともに、神経疾患の治療に有用な遺伝
子の候補でもある。発現頻度解析において、発現量に差
があるクローンの選抜は、例えば、高密度cDNAフィルタ
ーにおける解析では、複数回のハイブリダイゼーション
で得られた各クローンに対する複数個のシグナル値(プ
ローブ標識に使用したRIのシグナル値、あるいは蛍光物
質ならば蛍光強度の測定値)に対して、二標本t検定の統
計処理を行い、シグナル値の分布に有意に差があるクロ
ーンを、たとえばP<0.05で選択することにより可能であ
る。また、例えば二標本t検定の統計処理を行い、P<0.0
1で選抜することもできるし、有意なシグナル値の限度
値をあらかじめ設定して統計処理することなどで、より
明らかに発現量に差のある遺伝子を選抜することができ
る。一方で、単純に発現量の比較を行い、発現量比から
クローンの選抜を行う方法もある。あるいは、PCR法を
用いた発現頻度解析等では、PCRにより得られた増幅産
物量を比較し、発現量に差があるクローンの選抜を行う
ことができる。増幅産物量は、例えばエチジウムブロマ
イド染色でのバンド強度の測定、増幅産物に対して行っ
たハイブリダイゼーションでのプローブ標識に使用した
RIのシグナル値、あるいは蛍光標識ならば蛍光強度を測
定することにより比較することができる。複数回行われ
たPCR法を用いた解析で得られた増幅産物量が少なくと
も2倍以上ならば発現量に差があるクローンといえる
が、数倍あるいは10倍以上ならばより明らかに発現量に
差のある遺伝子として選抜することができる。初代培養
滑膜細胞をTNF-alfa存在下で培養して発現変化する遺伝
子を探索した結果、TNF-alfaで増加したクローンは、PS
EC0070、PSEC0073、PSEC0084、PSEC0100、PSEC0109、PS
EC0120、PSEC0131、PSEC0161、PSEC0183、PSEC0192、PS
EC0197、PSEC0205、PSEC0207、PSEC0210、PSEC0213、PS
EC0222、PSEC0230、PSEC0241、PSEC0252、PSEC0259であ
った。一方、TNF-alfaで減少したクローンは、PSEC010
5、PSEC0245であった。これらのクローンはリュウマチ
関連候補遺伝子である。神経系の培養細胞NT2を分化誘
導（レチノイン酸(RA)刺激）して発現変化する遺伝子を
探索した結果、PSEC0005、PSEC0048、PSEC0059、PSEC02
00、PSEC0232のクローンで発現変化があった。これらは
ニューロン分化と関連がある重要な遺伝子である。ま
た、PSEC0017、PSEC0019、PSEC0021、PSEC0030、PSEC00
41、PSEC0047、PSEC0049、PSEC0055、PSEC0066、PSEC00
70、PSEC0071、PSEC0072、PSEC0074、PSEC0075、PSEC00
76、PSEC0080、PSEC0081、PSEC0084、PSEC0088、PSEC00
94、PSEC0103、PSEC0104、PSEC0105、PSEC0112、PSEC01
13、PSEC0117、PSEC0119、PSEC0120、PSEC0127、PSEC01
29、PSEC0136、PSEC0139、PSEC0143、PSEC0144、PSEC01
52、PSEC0161、PSEC0169、PSEC0171、PSEC0181、PSEC01
82、PSEC0192、PSEC0195、PSEC0203、PSEC0215、PSEC02
23、PSEC0235、PSEC0239、PSEC0243、PSEC0251、PSEC02
55、PSEC0265のクローンでも発現変化が生じていた。こ
れらもニューロン分化に関連し、神経疾患関連の候補遺
伝子である。

【００３７】膜蛋白質の場合、細胞上に発現して受容体
やリガンドとして機能する蛋白質である可能性が高い。
したがって、本発明によって提供される膜蛋白質と、公
知の、あるいは新規なリガンドや受容体との結合活性に
基づいてスクリーニングすれば、新たなリガンド−受容
体の関係を見出すことができる。スクリーニングは公知
の方法に従って行うことができる。たとえば次のように
して本発明の蛋白質に対するリガンドをスクリーニング
することができる。すなわち（ａ）本発明の蛋白質また
はその部分ペプチド、またはそれらを発現する細胞に被
検試料を接触させる工程、および（ｂ）該蛋白質、該ペ
プチドまたは該細胞に結合する被検試料を選択する工
程、とによって特定の蛋白質に結合するリガンドのスク
リーニングが可能となる。一方、例えば、以下のように
して本発明の蛋白質の受容体を発現する細胞をスクリー
ニングすることもできる。すなわち、（ａ）本発明の蛋
白質またはその部分ペプチドに被検細胞試料を接触させ
る工程、および（ｂ）該蛋白質またはその部分ペプチド
に結合する細胞を選択する工程、とによって特定の蛋白
質に結合する受容体のスクリーニングが可能である。

【００３８】このスクリーニングは、例えば、以下のよ
うに行うことが可能である。まず、本発明の蛋白質を発
現させ組換え蛋白質の精製品を取得する。次いで、その
精製蛋白質を標識し、各種細胞株または初代培養細胞に
対して結合アッセイを行い、これにより受容体を発現し
ている細胞を選定する（本庶・新井・谷口・村松編新生
化学実験講座７ 増殖分化因子とその受容体p203-236 (1
991) 東京化学同人）。標識としては、¹²⁵IなどのRI標
識のほか、酵素（アルカリホスファターゼ等）標識も可
能である。また、本発明の蛋白質を標識せずに用いて、
本発明の蛋白質と受容体を発現している細胞とを結合さ
せた後に、本発明の蛋白質に対する抗体を標識して用い
て検出することも考えられる。上記スクリーニングによ
り得られた本発明の蛋白質の受容体を発現する細胞は、
後述するように該受容体のアゴニストやアンタゴニスト
のスクリーニングに用いることが可能である。上記のス
クリーニングにより、本発明の蛋白質が結合するリガン
ドや、本発明の蛋白質の受容体やその受容体を発現する
細胞が得られれば、それらリガンドや受容体と結合する
化合物のスクリーニングが可能となる。またそれらの結
合活性を指標に、両者の結合を阻害する化合物（例え
ば、受容体アゴニストやアンタゴニスト）のスクリーニ
ングが可能となる。

【００３９】このスクリーニング方法は、本発明の蛋白
質が受容体である場合は、（ａ）被検試料の存在下で、
本発明の蛋白質または本発明の蛋白質を発現する細胞と
リガンドとを接触させる工程、（ｂ）該蛋白質または該
蛋白質を発現する細胞とリガンドとの結合活性を検出す
る工程、および（ｃ）被検試料非存在下において検出し
た場合と比較して該結合活性を低下させる化合物を選択
する工程、とを含む。また本発明の蛋白質がリガンドで
ある場合には、（ａ）被検試料の存在下で、本発明の蛋
白質を該蛋白質の受容体または該受容体を発現する細胞
に接触させる工程、（ｂ）該蛋白質とその受容体または
該受容体を発現する細胞との結合活性を検出する工程、
および（ｃ）被検試料非存在下において検出した場合と
比較して、該結合活性を低下させる化合物を選択する工
程、を含む。スクリーニングに用いる被検試料として
は、例えば、細胞抽出液、遺伝子ライブラリーの発現産
物、合成低分子化合物、合成ペプチド、天然化合物など
が挙げられるが、これらに制限されない。また、本発明
の蛋白質との結合活性を指標とした上記のスクリーニン
グにより単離された化合物を被検試料として用いること
も可能である。このスクリーニングにより単離される化
合物は、本発明の蛋白質自体または本発明の蛋白質に対
する受容体のアゴニストやアンタゴニストの候補とな
る。本発明の受容体とリガンドとの結合活性の低下によ
るリン酸化などの細胞内シグナルの変化をもとに、得ら
れた化合物が本発明の蛋白質の受容体のアゴニストであ
るかアンタゴニストであるかを判定することができる。
また、スクリーニングによって得られる化合物は、生体
内において、本発明の蛋白質と相互作用する分子(受容
体も含む）との該相互作用を阻害する化合物の候補とも
なる。本発明の蛋白質、または本発明の蛋白質に結合す
る受容体、またはリガンド、更にはこれらの化合物は、
本発明の蛋白質が関連する疾患の予防薬や治療薬への応
用、または本発明の蛋白質が関連する疾患の検査薬への
応用などが考えられる。

【００４０】分泌蛋白質の場合、細胞の増殖・分化など
の細胞状態を制御する因子の可能性がある。新たな細胞
状態を制御する因子を見いだすためには、ある種の細胞
に、本発明によって提供される分泌蛋白質を加えること
によって、細胞の増殖・分化などの細胞の状態変化や、
細胞内の特定の遺伝子の活性化を指標にスクリーニング
すれば可能である。このスクリーニングは、例えば、以
下のように行うことが可能である。まず、本発明の蛋白
質を発現させ組換え蛋白質の精製品を取得する。次い
で、その精製蛋白質を、各種細胞株または初代培養細胞
に添加して、増殖・分化などの細胞の変化を調べる。ま
たは、ある特定の細胞の状態変化に影響を与えることが
知られている遺伝子の誘導をmRNA量、蛋白質量で検出す
る。あるいはある特定の細胞の状態変化に影響を与える
ことが知られている遺伝子産物（蛋白質）の働きにより
変化した細胞内の物質（低分子化合物など）量で検出す
る。このようなスクリーニングにより、本発明による蛋
白質が細胞状態、機能を制御するとなれば、本発明の蛋
白質は、関連した疾患に対して、そのまま、あるいは一
部適した状態に改変して、医薬品や検査薬への応用が考
えられる。また、先に膜タンパクについて記述したよう
に、本発明によって提供される分泌蛋白質を用いて、公
知のリガンドや受容体との結合活性に基づいてスクリー
ニングすれば、新たなリガンド−受容体の関係を見出す
ことができ、同様の方法でアゴニスト、アンタゴニスト
の判定が可能となる。こうして得られる化合物は、生体
内において、本発明の蛋白質と相互作用する分子(受容
体も含む）との該相互作用を阻害する化合物の候補とも
なる。これら化合物は、本発明の蛋白質が関連する疾患
の予防薬や治療薬、あるいは検査薬への応用が考えられ
る。

【００４１】あるいは、本発明の蛋白質や遺伝子が疾患
に関連していた場合、本発明による蛋白質を利用し、直
接的に、または、間接的に、その発現や活性調節を行う
化合物、遺伝子のスクリーニングが可能となる。例え
ば、まず、本発明の蛋白質を発現させ組換え蛋白質の精
製品を取得する。次に本発明の蛋白質と相互作用する蛋
白質や遺伝子を精製し、その結合に基づいてスクリーニ
ングを行う。または、予め阻害剤の候補となる化合物を
加えておいた後、それら結合の変化を観察することによ
ってスクリーニングを行う。このようなスクリーニング
によって得られた化合物は、本発明による蛋白質が関連
した疾患に対して医薬品や検査薬への応用が考えられ
る。スクリーニングによって得られた制御因子が蛋白質
であっても、同様に、蛋白質自体の医薬品への応用が考
えられるとともにその蛋白質の発現・活性に本来ない影
響を与える化合物があれば、その化合物は、本発明によ
る蛋白質が関連した疾患に対して医薬品や検査薬への応
用が考えられる。

【００４２】本発明による分泌蛋白質、あるいは膜蛋白
質が酵素としての活性を有するとなれば、本発明によっ
て提供される蛋白質に化合物を適当な条件下で添加し、
化合物の変化を指標としてその活性を明らかにすること
ができる。また、この活性を指標に本発明による蛋白質
の活性を阻害する化合物のスクリーニングも可能であ
る。このスクリーニングは、例えば、以下のように行う
ことが可能である。まず、本発明の蛋白質を発現させ組
換え蛋白質の精製品を取得する。次いで、その精製蛋白
質に、化合物を添加して、化合物量および反応生成物量
を調べる。または、予め阻害剤の候補となる化合物を加
えておいた後、精製蛋白質と反応する化合物（基質）を
加えて、その基質量および反応生成物量の変化を調べ
る。このようなスクリーニングにより、得られた化合物
は、本発明の蛋白質が関連した疾患に対して、医薬品へ
の応用が考えられる。また本発明の蛋白質が生体におい
て正常に機能しているかどうかを調べるなどの検査への
応用が考えられる。本発明の分泌蛋白質、あるいは膜蛋
白質が、新たな疾患関連蛋白質であるかどうかは、上記
に挙げた以外にも、本発明による蛋白質の特異認識抗体
を用いて、特定の疾患と蛋白質の発現量や活性との相関
を調べることにより知ることができる。あるいは、「Me
thod in Molecular Biology」(Humana Press社)シリー
ズの『Molecular Diagnosis of Genetic Diseases』（R
ob Elles編、1996）を参考に解析が可能である。

【００４３】本発明の分泌蛋白質、または膜蛋白質は、
組み換え蛋白質として、また天然の蛋白質として調製す
ることが可能である。組み換え蛋白質は、例えば、後述
するように本発明の蛋白質をコードするDNAを挿入した
ベクターを適当な宿主細胞に導入し、形質転換体内で発
現した蛋白質を精製することにより調製することが可能
である。一方、天然の蛋白質は、例えば、後述する本発
明の蛋白質に対する抗体を結合したアフィニティーカラ
ムを利用して調製することができる (CurrentProtocols
in Molecular Biology edit. Ausubel et al. (1987)
Publish. JhonWily & Sons Section 16.1-16.19)。アフ
ィニティー精製に用いる抗体は、ポリクローナル抗体で
あってもモノクローナル抗体であってもよい。また、イ
ンビトロトランスレーション（例えば、「On the fidel
ity of mRNA translation in the nuclease-treated ra
bbit reticulocyte lysate system. Dasso,M.C.,Jackso
n,R.J.(1989) NAR 17:3129-3144」参照）などにより本
発明の蛋白質を調製することも可能である。

【００４４】前記のようにして明らかにされた本発明の
蛋白質の活性に基づいて、本発明の蛋白質と機能的に同
等な蛋白質を得ることができる。ある蛋白質が本発明の
蛋白質と機能的に同等であるかどうかは、本発明の蛋白
質が備える生物学的な活性を指標として、該活性をある
蛋白質が有するかどうかを調べることによって確認する
ことができる。

【００４５】これら本発明において同定された蛋白質と
機能的に同等な蛋白質は、当業者であれば、例えば、蛋
白質中のアミノ酸配列に変異を導入する方法（例えば、
部位特異的変異誘発法(Current Protocols in Molecula
r Biology edit. Ausubel etal. (1987) Publish. Jhon
Wily & Sons Section 8.1-8.5)）を利用して調製する
ことができる。また、このような蛋白質は、自然界にお
けるアミノ酸の変異により生じることもある。本発明に
は、このように本実施例において同定された蛋白質と同
等の機能を有する限り、そのアミノ酸配列（表１）にお
いて１もしくは複数のアミノ酸が置換、欠失、挿入およ
び／または付加された蛋白質も含まれる。

【００４６】蛋白質におけるアミノ酸の変異数や変異部
位は、その機能が保持される限り制限はない。変異数
は、典型的には、全アミノ酸数の３０％以内、または２
０％以内、または１０％以内であり、好ましくは全アミ
ノ酸の5％以内、または３％以内であり、さらに好まし
くは全アミノ酸の２％以内であり、更に好ましくは全ア
ミノ酸の１％以内である。あるいは本発明には複数のア
ミノ酸として数個のアミノ酸の変異を置換する場合が含
まれる。数個とは、たとえば５、更には４または３、あ
るいは２、更には１のアミノ酸を言う。置換されるアミ
ノ酸は、蛋白質の機能の保持の観点から、置換前のアミ
ノ酸と似た性質を有するアミノ酸であることが好まし
い。例えば、Ala、Val、Leu、Ile、Pro、Met、Phe、Trp
は、共に非極性アミノ酸に分類されるため、互いに似た
性質を有すると考えられる。また、非荷電性としては、
Gly、Ser、Thr、Cys、Tyr、Asn、Glnが挙げられる。ま
た、酸性アミノ酸としては、AspおよびGluが挙げられ
る。また、塩基性アミノ酸としては、Lys、Arg、Hisが
挙げられる。

【００４７】また、本実施例において同定された蛋白質
と機能的に同等な蛋白質は、当業者に周知のハイブリダ
イゼーション技術あるいは遺伝子増幅技術を利用して単
離することも可能である。即ち、当業者であれば、ハイ
ブリダイゼーション技術 (Current Protocols in Molec
ular Biology edit. Ausubel et al. (1987) Publish.
Jhon Wily & Sons Section 6.3-6.4)を用いて本実施例
において同定された蛋白質をコードするDNAの塩基配列
（表１）またはその一部をもとにこれと同一性の高いDN
Aを単離して、該DNAから機能的に同等な蛋白質を得るこ
とは、通常行いうることである。本発明には、本実施例
において同定された蛋白質と同等の機能を有する限り、
これら蛋白質をコードするDNAとハイブリダイズするDNA
によりコードされる蛋白質も含まれる。機能的に同等な
蛋白質を単離する生物としては、例えば、ヒト、マウ
ス、ラット、ウサギ、ブタ、ウシ等の脊椎動物が挙げら
れるが、これらに制限されない。

【００４８】機能的に同等な蛋白質をコードするDNAを
単離するためのハイブリダイゼーションの条件は、洗浄
条件として通常「1xSSC、0.1% SDS、37℃」程度であ
り、より厳しい条件としては「0.5xSSC、0.1% SDS、42
℃」程度であり、さらに厳しい条件としては「0.1xSS
C、0.1% SDS、65℃」程度を示すことができる。あるい
は、次のような条件を本発明におけるハイブリダイゼー
ションの条件として示すこともできる。すなわち、ハイ
ブリダイゼーションを「6 x SSC、40 % ホルムアミド、
25 ℃」、洗浄を「1 x SSC、55 ℃」で行う条件を用い
ることができる。より好ましい条件としては、ハイブリ
ダイゼーションを「6 x SSC、40 % ホルムアミド、37
℃」、洗浄を「0.2 x SSC、55 ℃」で行う条件が挙げら
れる。さらに好ましい条件としては、ハイブリダイゼー
ションを「6 x SSC、50 % ホルムアミド、37 ℃」、洗
浄を「0.1 x SSC、62 ℃」で行う条件を用いることがで
きる。ハイブリダイゼーションの条件が厳しくなるほど
プローブ配列と高い同一性を有するDNAの単離を期待し
うる。したがって、ハイブリダイゼーションはストリン
ジェントな条件下で行うことが望ましい。本明細書にお
いてストリンジェントな条件としては、洗浄のための条
件としてたとえば「0.5xSSC、0.1% SDS、42℃」程度を
示すことができる。あるいは、ハイブリダイゼーション
を「6 x SSC、40% ホルムアミド、37 ℃」、洗浄を「0.
2 x SSC、55 ℃」で行う条件をストリンジェントな条件
として示すこともできる。なお、当業者であれば、SSC
の希釈率、ホルムアミド濃度、温度などの諸条件を適宜
選択することで、上記の条件と同様のストリンジェンシ
ーのハイブリダイゼーション条件を実現することができ
る。ただし、上記SSC、SDSおよび温度の条件の組み合わ
せは例示であり、当業者であれば、ハイブリダイゼーシ
ョンのストリンジェンシーを決定する上記若しくは他の
要素（例えば、プローブ濃度、プローブの長さ、ハイブ
リダイゼーション反応時間など）を適宜組み合わせるこ
とにより、上記と同様のストリンジェンシーを実現する
ことが可能である。

【００４９】このようなハイブリダイゼーション技術を
利用して単離される蛋白質は表１に記載の本発明の蛋白
質と比較して、通常、そのアミノ酸配列において高い同
一性を有する。本発明は、請求項１（ａ）に記載の塩基
配列に対して高い同一性を有する塩基配列を含むポリヌ
クレオチドを包含する。また本発明は、請求項１（ｂ）
に記載したポリヌクレオチドがコードするアミノ酸配列
に対して高い同一性を有するアミノ酸配列を含む蛋白
質、またはペプチドを包含する。高い同一性とは、少な
くとも４０％以上、好ましくは６０％以上、さらに好ま
しくは７０％以上の配列の同一性を指す。あるいはより
望ましくは、９０％以上、または９３％以上、あるいは
９５％以上、更には９７％以上、そして９９％以上の同
一性を言う。同一性は、BLAST検索アルゴリズムを用い
て決定することができる。本発明におけるアミノ酸配列
や塩基配列の同一性は、Karlin and Altschul によるア
ルゴリズムBLAST (Proc. Natl. Acad. Sei. USA 90:587
3-5877, 1993)によって決定することができる。このア
ルゴリズムに基づいて、BLASTNやBLASTXと呼ばれるプロ
グラムが開発されている(Altschul et al. J. Mol. Bio
l.215:403-410, 1990)。BLASTに基づいてBLASTNによっ
て塩基配列を解析する場合には、パラメーターはたとえ
ばscore = 100、wordlength = 12とする。また、BLAST
に基づいてBLASTXによってアミノ酸配列を解析する場合
には、パラメーターはたとえば score = 50、wordlengt
h = 3とする。BLASTとGapped BLASTプログラムを用いる
場合には、各プログラムのデフォルトパラメーターを用
いる。これらの解析方法の具体的な手法は公知である(h
ttp://www.ncbi.nlm.nih.gov.)。

【００５０】また、遺伝子増幅技術（PCR）（Current p
rotocols in Molecular Biology edit. Ausubel et a
l. (1987) Publish. John Wiley & Sons Section 6.1-
6.4）を用いて、本実施例において同定された塩基配列
（表１）の一部をもとにプライマーを設計し、これら塩
基配列またはその一部と同一性の高いDNA断片を単離し
て、これをもとに本実施例において同定された蛋白質と
機能的に同等な蛋白質を得ることも可能である。

【００５１】本発明はまた、表１に示した配列番号に記
載の塩基配列からなるポリヌクレオチド、またはその相
補鎖に相補的な少なくとも１５ヌクレオチドを含むポリ
ヌクレオチドを提供する。ここで「相補鎖」とは、A:
T、G:Cの塩基対からなる２本鎖DNAの一方の鎖に対する
他方の鎖を指す。また、「相補的」とは、少なくとも15
個の連続したヌクレオチド領域で完全に相補配列である
場合に限られず、少なくとも70% 、好ましくは少なくと
も80% 、より好ましくは90% 、さらに好ましくは95% 以
上の塩基配列上の相同性を有すればよい。塩基配列の相
同性は、本明細書に記載したアルゴリズムにより決定す
ることができる。

【００５２】このようなポリヌクレオチドは、本発明の
蛋白質をコードするポリヌクレオチドを検出、単離する
ためのプローブとして、また、本発明のポリヌクレオチ
ドを増幅するためのプライマーとして利用することが可
能である。プライマーとして用いる場合には、通常、15
bp〜100bp、好ましくは15bp〜35bpの鎖長を有する。ま
た、プローブとして用いる場合には、本発明のポリヌク
レオチドの少なくとも一部若しくは全部の配列を有し、
少なくとも15bpの鎖長のDNAが用いられる。プライマー
として用いる場合、3'側の領域は相補的である必要があ
るが、5'側には制限酵素認識配列やタグなどを付加する
ことができる。また、本発明のポリヌクレオチドには、
表１に示した配列番号に記載されたアミノ酸配列からな
る本発明の蛋白質の発現を抑制するためのアンチセンス
が含まれる。

【００５３】本発明のDNAやそのアンチセンスには、例
えば、遺伝子治療への応用が考えられる。遺伝子治療の
標的となる疾患としては、例えば、癌や各種炎症性疾患
が好適であると考えられる。これら分子を遺伝子治療に
用いる場合には、例えば、レトロウイルスベクター、ア
デノウイルスベクター、アデノ随伴ウイルスベクターな
どのウイルスベクターやリポソームなどの非ウイルスベ
クターなどを利用して、ex vivo法やin vivo法などによ
り患者へ投与を行えばよい。

【００５４】本発明は、また、本発明の蛋白質の部分ペ
プチドを含む。この部分ペプチドには、例えば、分泌蛋
白質におけるシグナルペプチドが除去された蛋白質が含
まれる。また、本発明の蛋白質が受容体やリガンドとし
ての活性を持つものの場合には、その競合阻害剤として
機能する、受容体（あるいはリガンド）との結合能を有
する部分ペプチドが含まれる。また、抗体調製のための
抗原ペプチドが含まれる。部分ペプチドが本発明の蛋白
質に特異的であるためには、少なくとも７アミノ酸、好
ましくは８アミノ酸以上、より好ましくは９アミノ酸、
更に好ましくは１０アミノ酸以上のアミノ酸配列からな
る。該部分ペプチドは、本発明の蛋白質に対する抗体や
本発明の蛋白質の競合阻害剤の調製以外に、例えば、本
発明の蛋白質に結合する受容体のスクリーニングなどに
利用し得る。本発明の部分ペプチドは、例えば、遺伝子
工学的手法、公知のペプチド合成法、あるいは本発明の
蛋白質を適当なペプチダーゼで切断することによって製
造する。

【００５５】また、本発明は、上記本発明の蛋白質をコ
ードするポリヌクレオチドに関する。本発明のポリヌク
レオチドとしては、本発明の蛋白質をコードしうるもの
であれば、その形態に特に制限はなく、cDNAの他、ゲノ
ムDNA、化学合成DNAなども含まれる。また、本発明の蛋
白質をコードしうる限り、遺伝暗号の縮重に基づく任意
の塩基配列を有するDNAが含まれる。本発明のポリヌク
レオチドは、上記のように、配列番号：１〜配列番号：
３３５の奇数番号に示す塩基配列もしくはその一部をプ
ローブとしたハイブリダイゼーション法やこれら塩基配
列をもとに合成したプライマーを用いたPCR法等の常法
により単離することが可能である。たとえば実施例にお
いて単離したクローン（１７３クローン）は全長であ
り、かつ膜蛋白質、あるいは分泌蛋白質をコードするも
のである。本発明に基づくすべてのcDNAクローンは、次
のように特徴付けることもできる。

【００５６】すなわち、オリゴキャップ法で取得された
全長性の高いcDNAであり、その5'末端配列データの特徴
をもとに、5'末端の全長性を予測するATGpr（あるいはA
TGpr1と記載している）のスコアにより選別されてお
り、さらにシグナル配列の存在を予測するPSORT により
N末端にシグナル配列、あるいはタンパクコーディング
領域中に膜貫通領域を有するものが選別されている。ま
た、選別されたクローンは5'末端配列の相同性検索によ
りヒトmRNAに対して同一でない（すなわち新規である）
ことが確認されている。

【００５７】また、本発明は、本発明のDNAが挿入され
たベクターに関する。本発明のベクターとしては、挿入
したDNAを安定に保持するものであれば特に制限され
ず、例えば 宿主に大腸菌を用いるのであれば、クロー
ニング用ベクターとしてはpBluescriptベクター(Strata
gene社製）などが好ましい。本発明の蛋白質を生産する
目的においてベクターを用いる場合には、特に発現ベク
ターが有用である。発現ベクターとしては、試験管内、
大腸菌内、培養細胞内、生物個体内で蛋白質を発現する
ベクターであれば特に制限されないが、例えば、試験管
内発現であればpBESTベクター（プロメガ社製）、大腸
菌であればpETベクター（Invitrogen社製）、培養細胞
であればpME18S-FL3ベクター（GenBank Accession No.
AB009864）、生物個体であればpME18Sベクター（Mol Ce
ll Biol. 8:466〜472(1988)）などが好ましい。ベクタ
ーへの本発明のDNAの挿入は常法により制限酵素サイト
を用いたリガーゼ反応により行うことができる（Curren
t protocols in Molecular Biology edit. Ausubel et
al. (1987) Publish. John Wiley & Sons．Section 1
1.4〜11.11）。

【００５８】また、本発明は、本発明のベクターを保持
する形質転換体に関する。本発明のベクターが導入され
る宿主細胞としては特に制限はなく、目的に応じて種々
の宿主細胞が用いられる。蛋白質を高発現させるための
真核細胞としては、例えば、COS細胞、CHO細胞などを例
示することができる。

【００５９】宿主細胞へのベクター導入は、例えば、リ
ン酸カルシウム沈殿法、電気パルス穿孔法（Current pr
otocols in Molecular Biology edit. Ausubel et al.
(1987) Publish. John Wiley & Sons．Section 9.1-9.
9）、リポフェクタミン法（GIBCO-BRL社製）、マイクロ
インジェクション法などの方法で行うことが可能であ
る。

【００６０】また本発明は、本発明の蛋白質をコードす
る配列番号：１〜配列番号：３３５の奇数番号に記載の
塩基配列からなるDNA、またはその相補鎖と相補的な塩
基配列からなる少なくとも15ヌクレオチドの鎖長を有す
るオリゴヌクレオチドに関する。本発明のオリゴヌクレ
オチドは、通常のハイブリダイゼーション条件下、好ま
しくは厳格な条件下で、本発明の蛋白質をコードする配
列番号：１〜配列番号：３３５の奇数番号に記載の塩基
配列からなるポリヌクレオチド、またはその相補鎖とハ
イブリダイズし、他の蛋白質をコードするDNAとは原則
としてハイブリダイズしないことが望ましい。このよう
なDNAは、本発明のDNAを検出、単離するためのプローブ
として、また、本発明のDNAを増幅するためのプライマ
ーとして利用することが可能である。プライマーとして
用いる場合には、通常、15bp〜100bp、好ましくは15〜5
0bp、より好ましくは15bp〜35bpの鎖長を有する。ま
た、プローブとして用いる場合には、本発明のDNAの少
なくとも一部若しくは全部の配列を有し、少なくとも15
bp、好ましくは30bp以上、更に好ましくは50bp以上の鎖
長のDNAが用いられる。

【００６１】なお本発明による全長cDNA合成用のプライ
マーを構成する塩基配列は、5'側が配列番号：３７０〜
配列番号：５４０、また3'側が配列番号：５４１〜配列
番号：６７９から選択することもできる。これらの塩基
配列の中には部分的にESTとして公知となっているもの
もあるが、本発明に基づくプライマーは全長cDNAの合成
を可能とする点において新規である。公知のESTは、そ
れがcDNAのどの部分に相当するのかという重要な情報が
欠落しているため、ESTに基づいてプライマーを設計す
ることができない。本発明の全ての全長cDNAは、5'末端
配列と3'末端配列から選択された塩基配列を含むプライ
マーセット、あるいは5'末端配列に基づいて選択された
プライマーとポリA配列に対応するオリゴdT配列とで構
成されるプライマーセットを使用し、PCR（Current pro
tocols in Molecular Biology edit. Ausubel et al.
(1987) Publish. John Wiley & Sons Section 6.1-6.
4）等の手法を用いることにより合成することができ
る。

【００６２】すなわち後に記載する表３４２に示した5'
側の塩基配列（配列番号：３７０〜配列番号：５４０）
から選択された塩基配列を持つポリヌクレオチドの相補
鎖に特異的にハイブリダイズする少なくとも１５ヌクレ
オチドからなる塩基配列を持つオリゴヌクレオチドを5'
側のプライマーとし、これに3'側プライマーとしてオリ
ゴｄＴプライマーを組み合わせてPCRを行えば良い。プ
ライマーの長さは、通常、15bp〜100bp、好ましくは15b
p〜35bpの鎖長を有する。後に述べるLA PCRに用いる場
合には、25〜35bpの長さとすると良い結果を得ることが
できる。与えられた塩基配列に基づいて、特異的な増幅
を可能とするプライマーを設計する手法は公知である
（Current protocols in Molecular Biology edit. Aus
ubel et al. (1987) Publish. John Wiley & Sons Sect
ion 6.1-6.4）。5'側の塩基配列に基づいてプライマー
を設計する際には、原則として増幅生成物が翻訳開始点
を含むようにする。したがって、たとえば5'側の塩基配
列として提供された塩基配列が5'側の非翻訳領域(5'UT
R)である場合には、対象となるcDNAに対する特異性を保
証できる限り、任意の部分を5'側のプライマーとして選
択することができる。翻訳開始点は、後に述べるATGpr
などの公知の方法によって推定することができる。

【００６３】全長cDNAを合成する場合には、その増幅対
象塩基配列は長いものでは数千bpにも及ぶ。しかしLA P
CR(Long and Accurate PCR)等を利用することにより、
このような長い領域の合成は可能である。長いDNAの合
成には、LA PCRを利用するのが有利である。LA PCRで
は、3'→5'エキソヌクレアーゼ活性を持った特殊なDNA
ポリメラーゼを用いることにより、誤って取りこまれた
塩基を除去できる。そのため、長い塩基配列であっても
正確に相補鎖合成を進めることが可能である。LAPCRを
利用すれば、望ましい条件においては、２０kb以上の増
幅が可能とされている。（林健志、実験医学別冊・PCR
の最新技術、羊土社,1996）本発明のcDNAを合成するた
めの鋳型となるDNAは、様々な方法によって調製したcDN
Aライブラリーを利用することができる。本発明におけ
る全長cDNAクローンは、[1]オリゴキャップ法による全
長率の高いcDNAライブラリーの作成、および[2]5'末端
側の配列からの全長性の評価システム（ESTに対して全
長でないものを除いた上で、ATGprによる評価に基づい
て選択）との組み合わせによって取得することができ
た、より全長である確率の高いクローンである。しか
し、本発明が提供するプライマーを利用すれば、必ずし
もこのような特殊な方法を用いずとも、容易に全長cDNA
の取得が可能となる。すなわち、公知の方法によって調
製されたcDNAライブラリー、あるいは市販のcDNAライブ
ラリーは、全長mRNAをまったく含まないものではなく、
その割合が非常に低い。したがって、通常のクローニン
グ方法では、これらのライブラリーから全長cDNAクロー
ンを直接スクリーニングすることは困難である。しか
し、本発明によって全長cDNAを合成することができるプ
ライマーが明らかにされた。プライマーさえ与えられれ
ば、PCRのような酵素的な合成方法を利用して目的とす
る全長cDNAを合成することが可能である。ただし、より
確実に全長cDNAの合成を行うには、たとえばオリゴキャ
ップ法等によって合成された全長率の高いcDNAライブラ
リーの使用が望ましいことは言うまでもない。

【００６４】本発明の全長cDNAクローンの5'-端配列を
利用すれば、ゲノム上のプロモーターを含む転写制御領
域を単離することが可能となる。2000年春にはヒトゲノ
ムの90%以上をカバーするラフドラフト（精度が少し低
いヒトゲノム配列解析）が完了し、さらに、2003年まで
にはヒト全ゲノム配列解析が完了する計画になってい
る。長いイントロンの存在するヒトゲノムより転写開始
点を解析ソフトで解析することは大きな困難がともな
う。しかし、本発明の全長cDNAクローンの5'-端配列を
用いれば、全長cDNAの5'-端配列からゲノム配列上でのm
RNA転写開始点を容易に特定できるため、転写開始点上
流配列の中に含まれるプロモーターを含む転写制御に関
わるゲノム領域を取得することが容易となる。

【００６５】本発明のDNAは、本発明の蛋白質の異常を
検査・診断するために利用できる。例えば、本発明のDN
Aをプローブやプライマーとして用いたノーザンハイブ
リダイゼーションやRT-PCRにより、発現異常を検査した
り、本発明のDNAをプライマーとして用いたポリメラー
ゼ連鎖反応(PCR)によりゲノムDNA-PCRやRT-PCRにより本
発明の蛋白質をコードするDNAやその発現制御領域を増
幅し、RFLP解析、SSCP、シークエンシング等の方法によ
り、配列の異常を検査・診断することができる。特に本
発明のmRNAの発現が特定の疾患によって変動する場合に
は、本発明のポリヌクレオチドをプローブやプライマー
として該mRNAの発現量を解析することによって該疾患の
検出や診断を行うことができる。

【００６６】また、「配列番号：１〜配列番号：３３５
の奇数番号に記載の塩基配列からなるポリヌクレオチ
ド、またはその相補鎖に相補的な塩基配列からなり、少
なくとも15ヌクレオチドの鎖長を有するポリヌクレオチ
ド」には、本発明の蛋白質の発現を抑制するためのアン
チセンスポリヌクレオチドが含まれる。アンチセンスポ
リヌクレオチドは、アンチセンス効果を引き起こすため
に、少なくとも15bp以上、たとえば50bp以上、好ましく
は100bp以上、さらに好ましくは500bp以上の鎖長を有
し、通常、3000bp以内、好ましくは2000bp以内の鎖長を
有する。このようなアンチセンスDNAには、本発明の蛋
白質の異常（機能異常や発現異常）などに起因した疾患
の遺伝子治療への応用も考えられる。該アンチセンスDN
Aは、例えば、本発明の蛋白質をコードするポリヌクレ
オチド（例えば、配列番号：１〜配列番号：３３５の奇
数番号に記載の塩基配列からなる）の配列情報を基にホ
スホロチオエート法（Stein, 1988 Physicochemical pr
operties of phosphorothioateoligodeoxynucleotides.
Nucleic Acids Res 16, 3209-21 (1988)）などにより
調製することが可能である。

【００６７】本発明のポリヌクレオチドまたはアンチセ
ンスポリヌクレオチドは、遺伝子治療に用いる場合に
は、例えば、レトロウイルスベクター、アデノウイルス
ベクター、アデノ随伴ウイルスベクターなどのウイルス
ベクターやリポソームなどの非ウイルスベクターなどを
利用して、ex vivo法やin vivo法などにより患者へ投与
を行う。

【００６８】また、本発明は、本発明の蛋白質に結合す
る抗体に関する。本発明の抗体の形態には特に制限はな
く、ポリクローナル抗体やモノクローナル抗体または抗
原結合性を有するそれらの一部も含まれる。また、全て
のクラスの抗体が含まれる。さらに、本発明の抗体に
は、ヒト化抗体やキメラ抗体などの特殊抗体も含まれ
る。

【００６９】本発明の抗体は、ポリクローナル抗体の場
合には、常法に従いアミノ酸配列に相当するオリゴペプ
チドを合成して家兎に免疫することにより得ることが可
能であり（Current protocols in Molecular Biology e
dit. Ausubel et al. (1987)Publish. John Wiley & So
ns. Section 11.12〜11.13）、一方、モノクローナル抗
体の場合には、常法に従い大腸菌で発現し精製した蛋白
質を用いてマウスを免疫し、脾臓細胞と骨髄腫細胞を細
胞融合させたハイブリドーマ細胞の中から得ることがで
きる（Current protocols in Molecular Biology edit.
Ausubel etal. (1987) Publish. John Wiley & Sons．
Section 11.4〜11.11）。

【００７０】本発明の蛋白質に結合する抗体は、本発明
の蛋白質の精製に加え、例えば、本発明の蛋白質の発現
異常や構造異常の検査・診断に利用することも考えられ
る。具体的には、例えば組織、血液、または細胞などか
ら蛋白質を抽出し、ウェスタンブロッティング、免疫沈
降、ELISA等の方法による本発明の蛋白質の検出を通し
て、発現や構造の異常の有無を検査・診断することがで
きる。

【００７１】また、本発明の蛋白質に結合する抗体を、
本発明の蛋白質に関連した疾患の治療などの目的に利用
することも考えられる。抗体を患者の治療目的で用いる
場合には、ヒト抗体、ヒト化抗体、あるいはキメラ抗体
が免疫原性の少ない点で好ましい。ヒト抗体は、免疫系
をヒトのものと入れ換えたマウス（例えば、「Function
al transplant of megabase human immunoglobulin loc
i recapitulates human antibody response in mice, M
endez, M.J. et al.(1997) Nat.Genet.15:146-156」参
照）に免疫することにより調製することができる。ま
た、ヒト化抗体は、モノクローナル抗体の超可変領域を
用いた遺伝子組み換えによって調製することができる(M
ethods in Enzymology 203, 99-121(1991))。

【００７２】更に本発明は、表１に記載のアミノ酸配列
および／または塩基配列から選択された少なくとも１つ
を含む全長cDNAおよび／または蛋白質データベース、ま
たはそのデータベースを記録した媒体にに関する。デー
タベースとは、塩基配列情報を検索可能な機械可読式の
情報として蓄積した情報の集合を意味する。本発明のデ
ータベースは、本発明によって提供されるcDNAの塩基配
列の少なくとも一つを含む。本発明のデータベースは、
本発明によって提供されるcDNAの情報のみから構成され
ていても良いし、公知の全長cDNAやEST等の塩基配列情
報をも含むものであることができる。本発明のデータベ
ースには、塩基配列情報のみならず、本発明によって明
らかにされた遺伝子の機能情報や、その全長cDNAを保持
したクローンの名称などの付随した情報を合わせて記録
したり、あるいはリンクさせておくことができる。本発
明のデータベースは、遺伝子断片の情報に基づく、遺伝
子全長の取得に有用である。本発明に基づくデータベー
スは、いずれも全長cDNAの塩基配列情報を含んでいる。
したがって、ディファレンシャルディスプレー法や、サ
ブトラクション法によって得られた遺伝子断片の塩基配
列を、このデータベースの情報に照合すれば、断片の塩
基配列に基づいて遺伝子の全長塩基配列を明らかにする
ことができる。しかも本発明のデータベースを構成する
全長cDNAの配列情報は、全長であることのみならず、遺
伝子の発現頻度情報や、公知の遺伝子や蛋白質との相同
性検索結果を伴っていることから、遺伝子断片の機能解
析を飛躍的に迅速化する。更に本発明のデータベース
は、ヒトの遺伝子に関する情報を蓄積しているものであ
ることから、他の種から単離された遺伝子の塩基配列情
報に基づくヒトのホモログの単離に有用である。現在で
は、ディファレンシャルディスプレー法や、サブトラク
ション法によって、さまざまな遺伝子断片情報を得るこ
とができる。一般にこれらの遺伝子断片は、その全長を
取得するためのツールとして用いられる。遺伝子断片が
公知の遺伝子のものであれば、公知のデータベースとの
照合によって、その全長を明らかにすることは容易であ
る。しかし、公知の遺伝子データベースに一致する塩基
配列を見出せない場合には、全長cDNAのクローニングを
行わなければならない。これらの断片情報に基づいて全
長塩基配列を取得する工程は、しばしば困難を伴う。遺
伝子の全長を取得しない限り、その遺伝子がコードする
蛋白質のアミノ酸配列は明らかにできない。したがっ
て、本発明のデータベースは、公知の遺伝子のデータベ
ースでは解明することのできない、遺伝子断片に対応す
る全長cDNAの特定に貢献する。

【００７３】

【実施例】次に、本発明を実施例によりさらに具体的に
説明するが、本発明は下記実施例に限定されるものでは
ない。 実施例１．オリゴキャップ法によるcDNAライブラリーの
作製 ヒト胎児精巣由来のテラトカルシノーマ細胞でレチノイ
ン酸処理により神経細胞に分化可能なNT-2神経前駆細胞
（Stratagene社より購入）を用いた。添付マニュアルに
従って、次の条件で培養細胞を調製した。 （１）NT-2細胞をレチノイン酸で誘導しないで培養（NT
2RM1） （２）NT-2細胞を培養後、レチノイン酸を添加して誘導
後、48時間培養（NT2RP1） （３）NT-2細胞を培養後、レチノイン酸を添加して誘導
後、2週間培養（NT2RP2とNT2RP3） これらの培養細胞をそれぞれ集めて、文献（J. Sambroo
k, E. F. Fritsch & T. Maniatis, Molecular Cloning
Second edition, Cold Spring harbor Laboratory Pres
s 1989）記載の方法によりmRNAを抽出した。さらに、オ
リゴdTセルロースでpoly(A)⁺RNAを精製した。同様に、
ヒト胎盤組織（PLACE1）、ヒト卵巣癌組織（OVARC1）、
ヒト胎児より脳を多く含む組織（HEMBA1）より、文献
（J. Sambrook, E. F. Fritsch & T. Maniatis, Molecu
lar Cloning Second edition, Cold Spring harbor Lab
oratoryPress, 1989）記載の方法によりmRNAを抽出し
た。さらに、オリゴdTセルロースでpoly(A)⁺RNAを精製
した。

【００７４】それぞれのpoly(A)⁺RNAよりオリゴキャッ
プ法 [M. Maruyama and S. Sugano,Gene, 138: 171-174
(1994)]によりcDNAライブラリーを作成した。Oligo-ca
p linker（配列番号：３３７）およびオリゴdTプライマ
ー（配列番号：３３８）を用いて文献 [鈴木・菅野, 蛋
白質 核酸 酵素, 41: 197-201 (1996)、 Y. Suzuki et
al., Gene, 200: 149-156 (1997)]の記載にしたがってB
AP（Bacterial Alkaline Phosphatase）処理、TAP（Tob
acco Acid Phosphatase）処理、RNAライゲーション、第
一鎖cDNAの合成とRNAの除去を行った。次いで、5'（配
列番号：３３９）と3'（配列番号：３４０）のPCRプラ
イマーを用いPCR (polymerase chain reaction)により
２本鎖cDNAに変換し、SfiI切断した。次いで、DraIIIで
切断したベクターpUC19FL3（図１）（NT2RM1とNT2RP1）
またはpME18SFL3（図１）（GenBankAB009864, Expressi
on vector）（NT2RP2、NT2RP3、PLACE1、OVARC1、HEMBA
1）にcDNAの方向性を決めてクローニングし、cDNAライ
ブラリーを作成した。これらより得たクローンのプラス
ミドDNAについて、NT2RM1、NT2RP1、NT2RP2、PLACE1、O
VARC1、HEMBA1については、挿入cDNAサイズが1 kb以下
のクローンを、また、NT2RP3については、挿入cDNAサイ
ズが2 kb以下のクローンを除いた後、cDNAの5'端と3'端
の塩基配列をDNAシーケンシング試薬（Dye Terminator
Cycle Sequencing FS Ready Reaction Kit, dRhodamine
Terminator Cycle Sequencing FS Ready Reaction Kit
またはBigDye Terminator Cycle Sequencing FS Ready
ReactionKit, PE Biosystems社製）を用い、マニュアル
に従ってシーケンシング反応後、DNAシーケンサー（ABI
PRISM 377, PE Biosystems社製）でDNA塩基配列を解析
した。こうして決定された、各クローンの5'末端側の塩
基配列を配列番号：３７０〜配列番号：５４０に、そし
て3'末端側の塩基配列を配列番号：５４１〜配列番号：
６７９に示した。各配列番号と、PSEC クローンとの対
応関係は表３４２に示すとおりである。

【００７５】NT2RM1とNT2RP1以外のオリゴキャップ高全
長率cDNAライブラリーは、真核細胞での発現が可能な発
現ベクターpME18SFL3を用いて作製した。pME18SFL3には
クローニング部位の上流にSRαプロモーターとSV40 sma
ll tイントロンが組み込まれており、またその下流には
SV40ポリA 付加シグナル配列部位が挿入されている。pM
E18SFL3のクローン化部位は非対称性のDraIIIサイトと
なっており、cDNA断片の末端にはこれと相補的なSfiI部
位を付加しているので、クローン化したcDNA断片はSRα
プロモーターの下流に一方向性に挿入される。したがっ
て、全長cDNAを含むクローンでは、得られたプラスミド
をそのままCOS細胞に導入することにより、一過的に遺
伝子を発現させることが可能である。すなわち、非常に
容易に、遺伝子産物である蛋白質として、あるいはそれ
らの生物学的活性として実験的に解析することが可能と
なっている。

【００７６】オリゴキャップ法で作製したライブラリー
のcDNAの5'-末端の全長率を次の方法で、求めた。公共
データベース中のヒト既知mRNAと5'-末端配列が一致す
る全クローンについて、公共データベース中の既知mRNA
配列より長く5'-末端が伸びている場合と5'-末端は短い
が翻訳開始コドンは有している場合を「全長」と判断
し、翻訳開始コドンを含んでいない場合を「非全長」と
判断した。各ライブラリーでのcDNAクローンの5'-末端
の全長率 [全長クローン数／（全長クローン数＋非全長
クローン数）] をヒト既知mRNAと比較することにより求
めた（NT2RM1：69%；NT2RP1：75%；NT2RP2：62%；NT2RP
3：61%；PLACE1：68%；OVARC1：59%；HEMBA1：53%）。
この結果より、5'-端配列の全長率が非常に高いことが
分かった。cDNAライブラリーとクローンとの関係は次の
とおりである。 NT2RM1：PSEC0001-PSEC0017 NT2RP1：PSEC0019-PSEC0047 NT2RP2：PSEC0048-PSEC0085、PSEC0092-PSEC0109、PSEC
0111-PSEC0113、PSEC0173 NT2RP3：PSEC0241-PSEC0265 PLACE1：PSEC0086-PSEC0090、PSEC0110、PSEC0117-PSEC
0172 OVARC1：PSEC0178-PSEC0183、PSEC0239-PSEC0240 HEMBA1：PSEC0190-PSEC0237

【００７７】実施例２．ATGprとESTiMateFLでのcDNAの
5'-末端の全長率の評価 ATGpr は、ATGコドンの周辺の配列の特徴から翻訳開始
コドンであるかどうかを予測するためにヘリックス研究
所のA. A. Salamov, T. Nishikawa, M. B. Swindellsが
開発したプログラムである [A. A. Salamov, T. Nishik
awa, M. B. Swindells, Bioinformatics, 14: 384-390
(1998); http://www.hri.co.jp/atgpr/]。結果は、その
ATGが真の開始コドンである期待値で表した（0.05-0.9
4）。このプログラムを全長率65%のオリゴキャップ法で
作製したライブラリーからのcDNAクローンの5'-末端配
列に適用してATGpr1値を0.6以上でクローンを選択した
場合、全長クローン（ORFのN-末端までもつクローン）
評価の感度と特異性はともに82〜83%まで上昇した。さ
らに、このプログラムをオリゴキャップ法で作製したヒ
トcDNAライブラリーからのクローンの5'-末端配列が既
知ヒトmRNAと一致する17,365クローンについて評価した
結果を示す。すなわち、既知ヒトmRNAと一致するクロー
ンについてATGpr1の最大値を求め、次いで各クローンの
5'-末端配列を既知ヒトmRNAのORFと比較し、全長か非全
長かを決定した。その結果をまとめたものを表２に示し
た。ATGprとオリゴキャップ法で作製したヒトcDNAライ
ブラリーからのクローンの組み合わせによる選択が、非
常に有効なことを示している。

【００７８】

【表２】 ＊ 全長の数：ORFのN-末端までもつクローンの数；非全
長の数：ORFのN-末端まで持っていないクローンの数；
全長率：全長の数／（全長＋非全長）の数

【００７９】ESTiMateFLは、公共データベース中のEST
の5'-末端配列や3'-末端配列との比較による全長cDNAの
可能性の高いクローンを選択するヘリックス研究所の西
川・太田らにより開発された方法である。この方法は、
あるcDNAクローンの5'-末端や3'-末端配列よりも、長く
伸びたESTが存在する場合には、そのクローンは「全長
ではない可能性が高い」と判断する方法で、大量処理可
能なようにシステム化したものである。公共データベー
ス中のEST配列より長く5'-末端が伸びている場合、およ
び5'-末端が短いクローンでも両者の差が50塩基以内で
ある場合を便宜的に全長とし、それ以上短い場合を非全
長とした。ESTとの比較による完全長らしさの評価で
は、比較対照とするESTの数が多ければ予測精度は高ま
るが、対象ESTが少ない場合には予測結果の信頼性が低
くなる欠点はある。この方法は、5'-末端配列での全長
率が約60%のオリゴキャップ法によるcDNAクローンから
全長ではない可能性の高いクローンを排除するのに使え
ば有効である。また、ESTiMateFLは、公共データベース
へのEST登録が適当数あるヒト未知mRNAのcDNAの3'-末端
配列の全長性を評価するには、特に有効な方法である。

【００８０】その結果をまとめたものを表３、および表
４に示した。ATGprとESTiMateFLの両プログラムを組み
合わせて、オリゴキャップ法で作製したヒトcDNAライブ
ラリーからのクローンの5'-末端配列の全長性を評価す
れば、ATGprの値の低いクローンでも全長率が高くなる
ことが確認された。この結果を全長cDNA配列を決めたク
ローンの5'-末端配列の全長性の評価に応用した。なお
表中、全長の数とはORFのN-末端までもつクローンの
数、非全長の数とはORFのN-末端までもっていないクロ
ーンの数、そして全長率とは全長の数／（全長＋非全
長）の数を意味する。

【００８１】

【表３】既知ヒトmRNAのORFと比較し、全長であると判
定したオリゴキャップ法で取得したcDNAクローンの5'-
末端配列のESTに対する全長率

【００８２】

【表４】既知ヒトmRNAのORFと比較し、非全長であると
判定したオリゴキャップ法で取得したcDNAクローンの5'
-末端配列のESTに対する全長率

【００８３】実施例３．シグナル配列をもつクローンの
選択とそれより全長率の高いクローンの選択 オリゴキャップ法で作成した各ライブラリーのクローン
から、5'-末端配列の中のすべてのATGコドンから予測さ
れる推定アミノ酸配列について、中井・金久が開発した
蛋白質の局在性予測プログラム「PSORT」 [K. Nakai &
M. Kanehisa,Genomics, 14: 897-911 (1992)]を用い、
多くの分泌蛋白質のアミノ末端に特徴的なシグナルペプ
チドと予測される配列の有無を解析することにより、シ
グナル配列をもつと予測されるクローン（分泌蛋白質、
または膜蛋白質の可能性が高い）を特異的に選別した。
PSEC0001-PSEC0066については、5'-端配列データに基づ
くATGprによる選別はしていない。しかし5'-端配列デー
タからシグナル配列（PSORTで解析）を持ち、かつ、5'-
端配列データでのORF（アミノ酸翻訳領域）が存在する
ものを選別したクローンである。また、PSEC0068-PSEC0
265については、5'-端配列データからATGpr1の最大値が
0.7以上で、シグナル配列（PSORTで解析）を持ち、か
つ、5'-端配列データでのORFが存在するものを選別した
クローンである。

【００８４】実施例４．全長cDNA配列解析とカテゴリー
分別 実施例３で選択した１７３クローンについて、全長cDNA
の塩基配列、並びに推定アミノ酸配列を決定した。塩基
配列は、次に示す３種の方法を組み合わせ、各方法によ
って決定した塩基配列を完全にオーバーラップさせ、最
終的な確定塩基配列を決定した。決定されたcDNA配列か
ら、推定アミノ酸配列を明らかにした。それらの結果を
配列表に示した。（分泌蛋白質、または膜蛋白質に分別
した１７３クローンについてのみ） （１）Licor DNAシーケンサーを用いたcDNA挿入断片両
末端からのロングリードシーケンス（Licorシーケンサ
ー（アロカ社販売）のマニュアルに従ってシーケンシン
グ反応後、LicorシーケンサーでDNA塩基配列を解析し
た）、 （２）AT2トランスポゾン試験管内転移を用いたPrimer
Island法によるネステッドシーケンス[S. E. Devine an
d J. D. Boeke, Nucleic Acids Res., 22: 3765-3772,
(1994)]（PE Biosystems社製のキットとマニュアルにし
たがってクローンを取得後、PE Biosystems社製のDNAシ
ーケンシング試薬でマニュアルに従ってシーケンシング
反応し、ABI PRISM 377でDNA塩基配列を解析した） （３）カスタム合成DNAプライマーを用いたダイデオキ
シターミネーター法によるプライマーウォーキング（カ
スタム合成DNAプライマーをもちいPE Biosystems社製の
DNAシーケンシング試薬でマニュアルに従ってシーケン
シング反応し、ABIPRISM 377でDNA塩基配列を解析し
た）

【００８５】これらの配列について、ATGprとPSORTによ
る解析およびGenBankやSwissProtに対するBLAST解析を
行った。ほとんどのクローン（１７３クローン中１５２
クローン）がN-末端にシグナル配列をもつ分泌蛋白質、
または膜蛋白質であると推定された。さらに、PSORTで
シグナル配列が検出されなかったクローン（PSEC0027,P
SEC0047, PSEC0066, nnnnnnnn, PSEC0069, PSEC0092, P
SEC0103, PSEC0117, PSEC0142, PSEC0212, PSEC0239, P
SEC0242, PSEC0251, PSEC0256, PSEC0006, PSEC0043, P
SEC0058, PSEC0195, PSEC0206, PSEC0211）について
は、MEMSATおよびSOSUIで膜蛋白質（transmembrane hel
ixをもつ）と予測できるかどうかを検索した。その結
果、２０クローン中の１４クローン（PSEC0027, PSEC00
47, PSEC0066, nnnnnnnn, PSEC0069, PSEC0092, PSEC01
03, PSEC0117, PSEC0142, PSEC0212,PSEC0239, PSEC024
2, PSEC0251, PSEC0256） にtransmembrane helixが存
在すると予測された。これらは、膜蛋白質であると推定
された。また、SwissProtとの相同性より、PSEC0195はm
ouse plasma membrane adaptor HA2/AP2 adaptin alpha
C subunitと、PSEC0206は分泌顆粒に存在するhuman ca
rboxypeptidase H precursor (prohormone processing
carboxypeptidase)に比較的高い相同性が見られた。

【００８６】以上の結果をリスト１、リスト２、リスト
３に示した。各cDNAクローンの機能アノテーションもリ
スト中に示した。また、１７３クローン中１６８クロー
ンのカテゴリーを次に示す。 １．分泌蛋白質、または膜蛋白質で全長cDNAクローンで
あると予測されるクローン（１６８クローン） （ほとんどのクローンのATGpr1の値が0.5以上） １）分泌蛋白質、または膜蛋白質でN-末端にシグナル配
列が存在し、全長cDNAクローンであると予測されるクロ
ーン（１５２クローン、リスト１参照) PSEC0001 PSEC0049 PSEC0085 PSEC0113 nnnnnnnn PSEC0051 PSEC0086 PSEC0119 PSEC0005 PSEC0052 PSEC0087 PSEC0120 PSEC0007 PSEC0053 PSEC0088 PSEC0121 PSEC0008 PSEC0055 PSEC0090 PSEC0124 PSEC0012 PSEC0059 PSEC0094 PSEC0125 PSEC0017 PSEC0061 PSEC0095 PSEC0126 PSEC0019 PSEC0068 PSEC0098 PSEC0127 PSEC0020 PSEC0070 PSEC0099 PSEC0128 PSEC0021 PSEC0071 PSEC0100 PSEC0129 PSEC0028 PSEC0072 PSEC0101 PSEC0130 PSEC0029 PSEC0073 PSEC0104 PSEC0131 PSEC0030 PSEC0074 PSEC0105 PSEC0133 PSEC0031 PSEC0075 PSEC0106 PSEC0134 PSEC0035 PSEC0076 PSEC0107 PSEC0135 PSEC0038 PSEC0077 PSEC0108 PSEC0136 PSEC0040 PSEC0079 PSEC0109 PSEC0137 PSEC0041 PSEC0080 PSEC0110 PSEC0139 PSEC0045 PSEC0081 PSEC0111 PSEC0143 PSEC0048 PSEC0082 PSEC0112 PSEC0144 nnnnnnnn PSEC0178 PSEC0216 PSEC0247 PSEC0147 PSEC0181 PSEC0218 PSEC0248 PSEC0149 PSEC0182 PSEC0220 PSEC0249 PSEC0150 PSEC0183 PSEC0222 PSEC0250 PSEC0151 PSEC0190 PSEC0223 PSEC0252 PSEC0152 PSEC0191 PSEC0224 PSEC0253 PSEC0158 PSEC0192 PSEC0226 PSEC0255 PSEC0159 PSEC0197 PSEC0227 PSEC0258 PSEC0161 PSEC0198 PSEC0228 PSEC0259 PSEC0162 PSEC0199 PSEC0230 PSEC0260 PSEC0163 PSEC0200 PSEC0232 PSEC0261 PSEC0164 PSEC0203 PSEC0233 PSEC0263 PSEC0165 PSEC0204 PSEC0235 PSEC0167 PSEC0205 PSEC0236 PSEC0168 PSEC0207 PSEC0240 PSEC0169 PSEC0209 PSEC0241 PSEC0170 PSEC0210 PSEC0243 PSEC0171 PSEC0213 PSEC0244 PSEC0172 PSEC0214 PSEC0245 PSEC0173 PSEC0215 PSEC0246 （注１） ATGpr1の値が0.5以下のクローン（PSEC0017,
ATGpr1 0.33; PSEC0030,ATGpr1 0.26; PSEC0031, ATGpr
1 0.20; PSEC0049, ATGpr1 0.35）： これらのクローン
は、5'-端配列データをATGprで選別はしておらず、5'-
端配列データからシグナル配列をもち、かつ、5'-端配
列データでのORFの長いものとして選別してきたクロー
ンを全長cDNA配列解析したものである。これらはすべて
N-末端にシグナル配列が存在していた。また、以上４ク
ローンのうちPSEC0049以外のものは、ESTとの比較の結
果cDNAの5'末端側に長かった。またPSEC0049は、ESTと
比較してcDNAのORFにおいて5'末端側に長かった。つま
り、これらのクローンがいずれも全長cDNAであることが
明らかである。

【００８７】２）分泌蛋白質、または膜蛋白質でN-末端
にシグナル配列は存在しないが膜蛋白質であり、全長cD
NAクローンであると予測されるクローン（１４クロー
ン、リスト２参照） PSEC0027 PSEC0047 PSEC0066 nnnnnnnn PSEC0069 PSEC0092 PSEC0103 PSEC0117 PSEC0142 PSEC0212 PSEC0239 PSEC0242 PSEC0251 PSEC0256 （注３）ATGpr1の値が0.5以下のクローン（PSEC0239, A
TGpr1 0.18）： PSEC0239は、5'-端配列データからATGp
r1の値が高くシグナル配列を持つと予測して選別したク
ローンである。このクローンは、全長解析後に予測され
るORFより、N-末端にシグナル配列が存在しないとの解
析結果になったが、MEMSATおよびSOSUIで膜蛋白質（tra
nsmembrane helixをもつ）であると予測された。また、
該当クローンについてESTとの比較をした結果、ESTに対
してcDNAの5'側に長いクローンであると判定された。 （注４）PSEC0242とPSEC0251：両クローンは3番目のATG
から翻訳がはじまるとすると"N-末端にシグナル配列が
存在"のカテゴリーに入る。 PSEC0242: No.3 ATG, ATGpr1 0.82, SP-Yes, ORF 171-1
343, 391 aa, Signal peptide 24aa; PSEC0251: No.3 ATG, ATGpr1 0.77, SP-Yes, ORF 116-1
256, 380 aa, Signal peptide 28aa.

【００８８】２．PSORT、MEMSAT、およびSOSUIの解析か
らは非分泌蛋白質、かつ非膜蛋白質だが、全長率の高い
オリゴキャップ法で作成したヒトcDNAライブラリーか
ら、ATGpr等で全長cDNAであると予測されるクローン（2
クローン） （両クローンともATGpr1の値が0.5以上） PSEC0195、PSEC0206 SwissProtとの相同性より、PSEC0195はmouse plasma me
mbrane adaptor HA2/AP2 adaptin alpha C subunitと、
PSEC0206は分泌顆粒に存在するhuman carboxypeptidase
H precursor (prohormone processing carboxypeptida
se)に比較的高い相同性が見られた。したがって、これ
らの蛋白質は、分泌蛋白質あるいは膜蛋白質のカテゴリ
ーに入る(リスト3参照)。

【００８９】実施例５．シグナル配列をもつと予測され
るクローンの選択 オリゴキャップ法で作成した各ライブラリーのクローン
から、5'-末端配列のすべてのATGコドンから予測される
推定アミノ酸配列について、中井・金久が開発した蛋白
質の局在性予測プログラム「PSORT」を用い、多くの分
泌蛋白質のアミノ末端に特徴的なシグナルペプチドと予
測される配列の有無を解析することにより、シグナル配
列をもつと予測されるクローン（分泌膜蛋白質の可能性
が高い）を特異的に選別した。すなわち、5'-端配列デ
ータからATGpr1の最大値が0.7以上で、シグナル配列（P
SORTで解析）をもち、かつ、5'-端配列データでのORFが
存在するクローンを選別した。それらのクローンのcDNA
ライブラリーとクローンとの関係は下記のようである。 NT2RP2：PSEC0078, PSEC0084 NT2RP3：PSEC0264, PSEC0265 HEMBA1：PSEC0237

【００９０】実施例６．全長cDNA配列解析とカテゴリー
分別 実施例５で選択した5クローンについて、全長cDNA配列
を前述の3種の方法を組み合わせて、両鎖の配列を完全
にオーバーラップさせ、確定配列を決定した。次に、決
定された全長塩基配列から推定アミノ酸配列を求めた。
それらの配列について、ATGprとPSORTによる解析および
GenBankやSwissProtに対するBLAST解析をおこなった。4
クローン（PSEC0084, PSEC0237, PSEC0264, PSEC0265）
がN-末にシグナル配列をもつ分泌膜蛋白質であると推定
された。さらに、PSORTでシグナル配列が検出されなか
った1クローン（PSEC0078）について、MEMSATとSOSUIで
膜蛋白質（transmembrane helixをもつ）と予測できる
かどうかを検索した結果、transmembrane helixが存在
すると予測された。すなわち、膜蛋白質であると推定さ
れた。BLAST解析ヒットデータの中から、機能の予測が
容易なヒットデータを選択して示した。しかし、単に相
同性の高いヒットデータを選択したものもある。以上の
結果をリスト１およびリスト２に示した。各cDNAクロー
ンの機能アノテーションもリスト１およびリスト２に示
してある。また、5クローンのカテゴリーを次に示す。
この５クローン以外の前述のcDNAクローンについても、
同様な基準でBLAST結果を示している。分泌膜蛋白質で
全長cDNAクローンであると予測されるクローン（5クロ
ーン） １）分泌膜蛋白質でN-末にシグナル配列が存在し、全長
cDNAクローンであると予測されるクローン（4クロー
ン）（リスト１参照） （ATGpr1の値が0.5以上） PSEC0084, PSEC0237, PSEC0264, PSEC0265 ２）分泌膜蛋白質でN-末にシグナル配列は存在しないが
膜蛋白質であり、全長cDNAクローンであると予測される
クローン（1クローン）（リスト２参照）PSEC0078 （注） ATGpr1の値は、0.24であったが、5'-端配列デー
タからATGpr1の値が高くシグナル配列を持つと予測して
選別したクローンである。このクローンは、全長解析後
に予測されるORFより、N-末にシグナル配列が存在しな
いとの解析結果になったが、MEMSATとSOSUIで膜蛋白質
（transmembrane helixをもつ）であると予測された。
また、ESTとの比較をした結果、cDNAの5'-端が50bp以上
短くて、ESTに対して非全長クローンであると判定され
るものはなかった。

【００９１】実施例７．高密度DNAフィルターを用い
た、ハイブリダイゼーションによる遺伝子発現解析 ナイロン膜スポット用のDNAは以下のように調製した。
すなわち、プラスミドを保持する大腸菌を96穴プレート
の各ウェルに培養し（LB培地で37度、16時間）、その培
養液の一部を、96穴プレートの10μlずつ分注した滅菌
水中に懸濁し、100度で10分間処理した後、PCR反応のサ
ンプルとして使用した。PCRはTaKaRa PCRAmplification
Kit（宝社製）を用い、プロトコールに従って1反応20
μlの反応溶液で行った。プラスミドのインサートcDNA
を増幅するために、プライマーはシークエンシング用の
プライマーME761FW (5'tacggaagtgttacttctgc3')とME12
50RV (5'tgtgggaggttttttctcta3')のペアー、またはM13
M4 (5'gttttcccagtcacgac3')とM13RV (5'caggaaacagcta
tgac3')のペアーを使用した。PCR反応は、GeneAmpSyste
m9600（PEバイオシステムズ社製）で、95度５分間処理
後、95度10秒、68度1分間で10サイクルし、さらに98度2
0秒間、60度3分間で20サイクル行い、72度10分間で行っ
た。PCR反応後、2 μlの反応液を1％アガロースゲル電
気泳動して、臭化エチジウムでDNAを染色し、増幅したc
DNAを確認した。増幅できなかったものは、そのcDNAイ
ンサートをもつプラスミドを、アルカリ抽出法（J Samb
rook,EF Fritsh, T Maniatis, Molecular Cloning, A l
aboratory manual / 2nd edition, Cold Spring Harbor
Laboratory Press, 1989）で調製した。

【００９２】DNAアレイの作製は以下のように行った。3
84穴プレートの各ウェルにDNAを分注した。ナイロン膜
（ベーリンガー社製）へのDNAのスポッティングは、Bio
mek2000ラボラトリーオートメーションシステム（ベッ
クマンコールター社製）の384ピンツールを用いて行っ
た。すなわち、DNAの入った384穴プレートをセットし
た。そのDNA溶液に、ピンツールの384個の独立した針を
同時に浸漬し、DNAを針にまぶした。その針を静かにナ
イロン膜に押し当てることによって、針に付着したDNA
をナイロン膜にスポッティングした。スポットしたDNA
の変性および、ナイロン膜への固定は定法（J Sambroo
k, EF Fritsh, T Maniatis, Molecular Cloning, A lab
oratory manual / 2nd edition, Cold Spring Harbor L
aboratory Press, 1989）に従って行った。ハイブリダ
イゼーションのプローブとしては、ラジオアイソトープ
でラベリングした1st strand cDNAを使用した。1st str
and cDNAの合成はThermoscript^TM RT-PCR System（GIBC
O社製）を用いて行った。すなわち、ヒトの各組織由来m
RNA（Clontech社製）の1.5 μgと、1 μl 50 μM Oligo
(dT)20を用いて、50 μCi[α³³P]dATPを添加して付属
のプロトコールに従って1st strand cDNAを合成した。
プローブの精製は、ProbeQuant^TM G-50 micro column
（アマシャムファルマシアバイオテック社製）を用いて
付属のプロトコールに従って行った。次に、2 units E.
coli RNase Hを添加して、室温で10分間インキュベー
トし、さらに100μgヒトCOT-1 DNA（GIBCO社製）を添加
して、97度で10分間インキュベート後、氷上に静置して
ハイブリダイゼーション用のプローブとした。

【００９３】ラジオアイソトープラベルしたプローブ
の、DNAアレイへのハイブリダイゼーションは、定法（J
Sambrook, EF Fritsh, T Maniatis, Molecular Clonin
g, Alaboratory manual / 2nd edition, Cold Spring H
arbor Laboratory Press, 1989）に従って行った。洗浄
は、ナイロン膜を洗浄液１（2X SSC, 1% SDS）中で、室
温（約26度）で20分間のインキュベートを3回洗浄した
後、洗浄液2（0.1X SSC, 1% SDS）中で、65度で20分間
の洗浄を3回行った。オートラジオグラムは、BAS2000
（富士写真フィルム社製）のイメージプレートを用いて
取得した。すなわち、ハイブリダイゼーションしたナイ
ロン膜をサランラップに包み、イメージプレートの感光
面に密着させて、ラジオアイソトープ感光用のカッセッ
トに入れて、暗所で4時間静置した。イメージプレート
に記録したラジオアイソトープ活性は、BAS2000を用い
て解析し、オートラジオグラムの画像ファイルとして電
子的に変換して記録した。各DNAスポットのシグナル強
度の解析は、Visage High Density Grid Analysis Syst
ems（ジェノミックソリューソンズ社製）を用いて行
い、シグナル強度を数値データ化した。データはDuplic
ateで取得し、その再現性は2つのDNAフィルターを1つの
プローブでハイブリダイゼーションして、両フィルター
で対応するスポットのシグナル強度を比較した（図
２）。全スポットの95%が、相当するスポットに対して2
倍以内のシグナル値であり、相関係数はr=0.97である。
データの再現性は十分といえる。

【００９４】遺伝子発現解析の検出感度は、ナイロン膜
にスポットしたDNAに相補的なプローブを作製し、ハイ
ブリダイゼーションにおける、プローブ濃度依存的なス
ポットのシグナル強度の増加を検討して見積もった。DN
Aとしては、PLACE1008092（GenBank Accession No.AF10
7253と同一）を使用した。前述の方法でPLACE1008092の
DNAアレイを作製した。プローブとしては、PLACE100809
2のmRNAをin vitro合成し、このRNAを鋳型として、前述
のプローブ作製法と同様にして、ラジオアイソトープで
ラベリングした1st strand cDNAを合成して使用した。P
LACE1008092のmRNAをin vitro合成するために、pBluesc
ript SK(-)のT7プロモーター側にPLACE1008092の5'末端
が結合されるように組み替えたプラスミドを造成した。
すなわち、pME18SFL3の制限酵素DraIII認識部位に組み
込まれたPLACE1008092を、制限酵素XhoIで切断してPLAC
E1008092を切り出した。次にXhoIで切断してあるpBlues
cript SK(-)と、切り出したPLACE1008092をDNA ligatio
n kit ver.2（宝社製）を用いてライゲーションした。p
Bluescript SK(-)に組み替えたPLACE1008092のmRNAのin
vitro合成は、Ampliscribe^TM T7 high yield transcri
ption kit（Epicentre technologies社製）を用いて行
った。ハイブリダイゼーションおよび各DNAスポットの
シグナル値の解析は、前述の方法と同様に行った。プロ
ーブ濃度が1x10⁷ μg/ml以下では、プローブ濃度に比例
したシグナル増加が無いことから、この濃度域でのシグ
ナルの比較は困難と考えられ、シグナル強度が40以下の
スポットは一様に低レベルのシグナルとした（図３）。
1x10⁷〜0.1 μg/mlの範囲でプローブ濃度依存的なシグ
ナル値の増加があり、検出感度としてはサンプルあたり
発現量比が1:100,000のmRNAの検出感度である。

【００９５】ヒト正常組織（heart;心臓、lung;肺、pit
uitary gland;下垂体、thymus;胸腺、brain;脳、kidne
y;腎臓、liver;肝臓、spleen;脾臓）における、各cDNA
の発現を表５〜１６１に示す（表中には実施例で説明の
無いクローンも含まれている）。発現量は0〜10,000の
数値で示した。少なくとも１つの組織で発現の認められ
る遺伝子は以下のクローンである。クローン：HEMBA100
0446、HEMBA1000675、HEMBA1001322、HEMBA1001552、HE
MBA1001680、HEMBA1001879、HEMBA1002441、HEMBA10027
06、HEMBA1002715、HEMBA1002913、HEMBA1002981、HEMB
A1003280、HEMBA1003702、HEMBA1003764、HEMBA100410
0、HEMBA1004633、HEMBA1005096、HEMBA1005452、HEMBA
1005628、HEMBA1005833、HEMBA1006099、HEMBA100639
1、HEMBA1006813、HEMBA1007104、HEMBA1007186、NT2RM
1000558、NT2RP1000125、NT2RP1000279、NT2RP100083
7、NT2RP1001023、NT2RP2000396、NT2RP2000428、NT2RP
2000557、NT2RP2000601、NT2RP2000720、NT2RP200108
7、NT2RP2001142、NT2RP2001270、NT2RP2001341、NT2RP
2001499、NT2RP2001508、NT2RP2001768、NT2RP200242
9、NT2RP2002695、NT2RP2002907、NT2RP2002927、NT2RP
2002934、NT2RP2003050、NT2RP2003115、NT2RP200322
7、NT2RP2003902、NT2RP2004130、NT2RP2004755、NT2RP
2004795、NT2RP2004966、NT2RP2005219、NT2RP200532
2、NT2RP2005671、NT2RP2005970、NT2RP2006435、NT2RP
3000234、NT2RP3000266、NT2RP3000326、NT2RP300063
8、NT2RP3000719、NT2RP3001359、NT2RP3001613、NT2RP
3001861、NT2RP3003097、NT2RP3003235、NT2RP300325
8、NT2RP3003368、NT2RP3003549、NT2RP3003731、NT2RP
3003789、NT2RP3004541、OVARC1000636、OVARC100184
9、PLACE1000456、PLACE1001098、PLACE1001300、PLACE
1001904、PLACE1002376、PLACE1002379、PLACE100340
5、PLACE1003724、PLACE1004113、PLACE1004273、PLACE
1004757、PLACE1004850、PLACE1005047、PLACE100576
0、PLACE1006472、PLACE1006610、PLACE1007635、PLACE
1009580、PLACE1010330、PLACE1010482、PLACE101113
4、PLACE1011146、PLACE1011360、PLACE1011386、PLACE
1011514、PLACE1011835。

【００９６】これら全ての組織で発現の認められる遺伝
子は以下のクローンである。クローン： HEMBA100271
5、NT2RP1001023、NT2RP2000396、NT2RP2003902、NT2RP
2005970、NT2RP3003258、NT2RP3003731、PLACE100340
5、PLACE1003724、。

【００９７】これらどの組織でも発現の低い遺伝子は以
下のクローンである。 クローン：HEMBA1000296、HEMBA1001490、HEMBA100407
8、HEMBA1004149、HEMBA1005301、HEMBA1005703、HEMBA
1006019、HEMBA1006549、HEMBA1007053、NT2RM100006
6、NT2RM1000566、NT2RM1000634、NT2RM1000726、NT2RM
1000853、NT2RM1001103、NT2RP1000255、NT2RP100047
7、NT2RP1000533、NT2RP1000544、NT2RP1000567、NT2RP
1000593、NT2RP1000769、NT2RP1000905、NT2RP100092
1、NT2RP1001042、NT2RP2000028、NT2RP2000116、NT2RP
2000168、NT2RP2000279、NT2RP2000358、NT2RP200211
5、NT2RP2003471、NT2RP2004036、NT2RP2004049、NT2RP
2004076、NT2RP2004974、NT2RP2005670、NT2RP200602
8、NT2RP2006400、NT2RP2006476、NT2RP3001619、NT2RP
3001874、NT2RP3002337、NT2RP3003536、NT2RP300405
9、NT2RP3004063、OVARC1000363、OVARC1001499、OVARC
1001510、OVARC1001636、PLACE1001022、PLACE100308
5、PLACE1003378、PLACE1003549、PLACE1004170、PLACE
1004322、PLACE1004507、PLACE1004904、PLACE100626
9、nnnnnnnnnnnn、PLACE1007190、PLACE1007338、PLACE
1007878、PLACE1007885、PLACE1008738、PLACE100899
4、PLACE1009772、PLACE1010021、PLACE1010978。

【００９８】これらのデータを統計解析することによっ
て、発現に特徴のある遺伝子を選別した。発現量が各組
織間において大きく変動する遺伝子を選別する例を２つ
示す。一般にコントロールとして使用されるβ actinの
発現に比べて、発現量が各組織間において大きく変動す
る遺伝子は、以下のように決定した。すなわちβ actin
の各組織でのシグナル強度の偏差平方和を求め、自由度
7で除して分散S_a ²を決定した。次に比較する遺伝子の各
組織でのシグナル強度の偏差平方和を求め、自由度7で
除してその分散S_b ²を決定した。分散比F= S_b ²/ S_a ²とし
て、F分布の有意水準5%以上の遺伝子を抽出した。抽出
した遺伝子は以下のクローンである。 クローン：NT2RP1001023(PSEC0045)。

【００９９】発現の変動の比較的少ないOVARC1000037
｛heterogeneous nuclear ribonucleoprotein (hnRN
P)｝の発現に比べて、発現量が各組織間で大きく変動す
る遺伝子は、以下のように決定した。すなわちOVARC100
0037の各組織でのシグナル強度の偏差平方和を求め、自
由度7で除して分散S_a ²を決定した。次に比較する遺伝子
の各組織でのシグナル強度の偏差平方和を求め、自由度
7で除してその分散S_b ²を決定した。分散比F= S_b ²/ S_a ²
として、F分布の有意水準5%以上の遺伝子を抽出した。
抽出した遺伝子は以下のクローンである。 クローン：NT2RP1001023 (PSEC0045)、NT2RP2005970 (P
SEC0084)、 このように多数の遺伝子の発現を比較し統計解析するこ
とによって、ある遺伝子の発現の特徴を示した。

【０１００】神経細胞分化関連遺伝子の解析 神経細胞の分化に関する遺伝子は、神経疾患の治療に有
用な遺伝子である。神経系の細胞を分化誘導して発現変
化する遺伝子は、神経疾患に関すると考えられる。神経
系の培養細胞NT2を分化誘導（レチノイン酸(RA)刺激）
して発現変化する遺伝子を探索した。NT2細胞の取扱い
については、基本的に付属のINSTRACTION MANUALに従っ
た。未分化NT2細胞とは、OPTI-MEM I (GIBCO BRL社製、
カタログNo.31985)、10%(v/v) fetal bovine serum(GIB
CO BRL社製)、1%(v/v) penicillin-streptomycin(GIBCO
BRL社製)の培地で継代していたNT2細胞である。レチノ
イン酸存在下で培養したNT2細胞とは、未分化NT2細胞を
D-MEM(GIBCO BRL社製、カタログNo.11965)、10%(v/v) f
etal bovine serum、1%(v/v) penicillin-streptomyci
n、10μM Retinoic acid(GIBCO BRL社製)のレチノイン
酸添加培地に移した後、5週間継代後の細胞である。RA
存在下で培養してさらに阻害剤を添加して培養したNT2
細胞とは、レチノイン酸添加5週間を経たNT2細胞を細胞
分裂阻害剤を添加した培地D-MEM(GIBCO BRL社製、カタ
ログNo.11965)、10%(v/v) fetal bovine serum、1%(v/
v) penicillin-streptomycin、10μM Retinoic acid、1
0μM FudR(5-Fluoro-2'-deoxyuridine：GIBCO BRL社
製)、10μM Urd(Uridine：GIBCO BRL社製)、1μM araC
(Cytosine β-D-Arabinofuranoside：GIBCO BRL社製)に
移した後２週間後の細胞である。それぞれの細胞はトリ
プシン処理して回収後、total RNAの抽出を、S.N.A.P.
^TM total RNA isolation kit（Invitrogen^(r)社製）を
用いて行った。ハイブリダイゼーション用のプローブの
ラベリングは、このtotal RNA 10 μgを用いて、前記の
方法で同様にして行った。データはn = 3で取得し、分
化誘導刺激ありの細胞のシグナルと、なしの細胞のシグ
ナルを比較した。比較には二標本t検定の統計処理を行
って、シグナル値の分布に有意に差があるクローンを、
p < 0.05で選択した。本解析は、シグナル値の低いクロ
ーンであっても差を統計的に検出できる。したがって40
以下のシグナル値のクローンに対しても評価を行った。
未分化のNT2細胞、RA存在下で培養したNT2細胞、または
RA存在下で培養してさらに阻害剤を添加して培養したNT
2細胞の、各cDNAの発現を表１６２〜３４１に示す。そ
れぞれ細胞の各遺伝子についてシグナル値の平均（M₁,
M₂）と標本分散（s₁ ², s₂ ²）を求め、比較する２つの細
胞の標本分散から合成標本分散s²を求めた。t = (M₁ -
M₂)/s/(1/3+1/3)^1/2を求めた。自由度４としてt分布表
の有意水準の確率Pである0.05と0.01のt値と比較して、
値が大きい場合にそれぞれP<0.05、またはP<0.01で両細
胞の遺伝子の発現に差があると判定した。未分化の細胞
に比べてシグナルの平均値が、増加（+）または減少を
（-）記した。

【０１０１】RAで増加したクローン：PSEC0017、PSEC00
21、PSEC0041、PSEC0047、PSEC0049、PSEC0055、PSEC00
66、PSEC0070、PSEC0071、PSEC0072、PSEC0074、PSEC00
75、PSEC0076、PSEC0080、PSEC0084、PSEC0088、PSEC00
94、PSEC0103、PSEC0105、PSEC0112、PSEC0113、PSEC01
19、PSEC0127、PSEC0129、PSEC0139、PSEC0143、PSEC01
44、PSEC0152、PSEC0171、PSEC0181、PSEC0182、PSEC01
92、PSEC0195、PSEC0200、PSEC0203、PSEC0215、PSEC02
23、PSEC0235、PSEC0239、PSEC0243、PSEC0255、PSEC02
65。 RA／阻害剤で増加したクローン：PSEC0017、PSEC0019、
PSEC0030、PSEC0041、PSEC0047、PSEC0048、PSEC0049、
PSEC0059、PSEC0066、PSEC0072、PSEC0081、PSEC0084、
PSEC0094、PSEC0104、PSEC0117、PSEC0119、PSEC0120、
PSEC0129、PSEC0136、PSEC0139、PSEC0143、PSEC0152、
PSEC0161、PSEC0169、PSEC0181、PSEC0182、PSEC0192、
PSEC0203、PSEC0223、PSEC0235、PSEC0251、PSEC0265。 RAとRA／阻害剤の両方で増加したクローン：PSEC0017、
PSEC0041、PSEC0047、PSEC0049、PSEC0066、PSEC0072、
PSEC0084、PSEC0094、PSEC0119、PSEC0129、PSEC0139、
PSEC0143、PSEC0152、PSEC0181、PSEC0182、PSEC0192、
PSEC0203、PSEC0223、PSEC0235、PSEC0265。 これらのクローンは神経疾患に関するクローンである。

【０１０２】リウマチ関連遺伝子の解析 慢性関節リュウマチの成因には、関節腔の内面を覆って
いる滑膜細胞の増殖や、関節滑膜組織に浸潤した白血球
が産生するサイトカインの作用による炎症反応が関係し
ていると考えられている（リュウマチ情報センター、ht
tp://www.rheuma-net.or.jp/）。最近の研究によれば、
tissue necrosis factor (TNF) -alfaが関与することが
わかっている（Current opinion in immunology 1999,
11:657-662）。TNFが滑膜細胞に作用して発現変化する
遺伝子は、リュウマチに関すると考えられる。

【０１０３】初代培養滑膜細胞をTNF-alfa存在下で培養
して発現変化する遺伝子を探索した。初代培養平滑筋細
胞（Cell Applications社製）は、培養皿にコンフルエ
ントに培養して、10 ng/ml human TNF-alfa（ベーリン
ガーマンハイム社製）を終濃度にして添加してさらに２
４時間培養した。細胞からのtotal RNAの抽出は、S.N.
A.P.^(TM) total RNA isolation kit（Invitrogen社製）
を用いて行った。ハイブリダイゼーション用のプローブ
のラベリングは、このtotal RNA 10 μgを用いて、前記
の方法で同様にして行った。データはn = 3で取得し、T
NF刺激ありの細胞のシグナル値と、なしの細胞のシグナ
ル値を比較した。比較には二標本t検定の統計処理を行
って、シグナル値の分布に有意に差があるクローンを、
p < 0.05で選択した。本解析は、シグナル値の低いクロ
ーンであっても差を統計的に検出できる。したがって40
以下のシグナル値のクローンに対しても評価を行った。
滑膜細胞、TNF存在下で培養した滑膜細胞の、各cDNAの
発現を表３４３に示す。

【０１０４】それぞれ細胞の各遺伝子についてシグナル
値の平均（M₁, M₂）と標本分散（s₁ ², s₂ ²）を求め、比
較する２つの細胞の標本分散から合成標本分散s²を求め
た。t = (M₁ - M₂)/s/(1/3+1/3)^1/2を求めた。自由度４
としてt分布表の有意水準の確率Pである0.05と0.01のt
値と比較して、値が大きい場合にそれぞれP<0.05、また
はP<0.01で両細胞の遺伝子の発現に差があると判定し
た。未分化の細胞に比べてシグナルの平均値が、増加
（+）または減少を（-）記した。

【０１０５】TNF-alfaで増加したPSECクローン：PSEC00
70、PSEC0073、PSEC0084、PSEC0100、PSEC0109、PSEC01
20、PSEC0131、PSEC0161、PSEC0183、PSEC0192、PSEC01
97、PSEC0205、PSEC0207、PSEC0210、PSEC0213、PSEC02
22、PSEC0230、PSEC0241、PSEC0252、PSEC0259。 TNF-alfaで減少したPSECクローン：PSEC0105、PSEC024
5。 これらのクローンはリュウマチに関するクローンであ
る。

【０１０６】

【表５】各cDNAのヒト組織における発現（表中には実施
例で説明の無いクローンも含まれている。表中）

【０１０７】

【表６】

【０１０８】

【表７】

【０１０９】

【表８】

【０１１０】

【表９】

【０１１１】

【表１０】

【０１１２】

【表１１】

【０１１３】

【表１２】

【０１１４】

【表１３】

【０１１５】

【表１４】

【０１１６】

【表１５】

【０１１７】

【表１６】

【０１１８】

【表１７】

【０１１９】

【表１８】

【０１２０】

【表１９】

【０１２１】

【表２０】

【０１２２】

【表２１】

【０１２３】

【表２２】

【０１２４】

【表２３】

【０１２５】

【表２４】

【０１２６】

【表２５】

【０１２７】

【表２６】

【０１２８】

【表２７】

【０１２９】

【表２８】

【０１３０】

【表２９】

【０１３１】

【表３０】

【０１３２】

【表３１】

【０１３３】

【表３２】

【０１３４】

【表３３】

【０１３５】

【表３４】

【０１３６】

【表３５】

【０１３７】

【表３６】

【０１３８】

【表３７】

【０１３９】

【表３８】

【０１４０】

【表３９】

【０１４１】

【表４０】

【０１４２】

【表４１】

【０１４３】

【表４２】

【０１４４】

【表４３】

【０１４５】

【表４４】

【０１４６】

【表４５】

【０１４７】

【表４６】

【０１４８】

【表４７】

【０１４９】

【表４８】

【０１５０】

【表４９】

【０１５１】

【表５０】

【０１５２】

【表５１】

【０１５３】

【表５２】

【０１５４】

【表５３】

【０１５５】

【表５４】

【０１５６】

【表５５】

【０１５７】

【表５６】

【０１５８】

【表５７】

【０１５９】

【表５８】

【０１６０】

【表５９】

【０１６１】

【表６０】

【０１６２】

【表６１】

【０１６３】

【表６２】

【０１６４】

【表６３】

【０１６５】

【表６４】

【０１６６】

【表６５】

【０１６７】

【表６６】

【０１６８】

【表６７】

【０１６９】

【表６８】

【０１７０】

【表６９】

【０１７１】

【表７０】

【０１７２】

【表７１】

【０１７３】

【表７２】

【０１７４】

【表７３】

【０１７５】

【表７４】

【０１７６】

【表７５】

【０１７７】

【表７６】

【０１７８】

【表７７】

【０１７９】

【表７８】

【０１８０】

【表７９】

【０１８１】

【表８０】

【０１８２】

【表８１】

【０１８３】

【表８２】

【０１８４】

【表８３】

【０１８５】

【表８４】

【０１８６】

【表８５】

【０１８７】

【表８６】

【０１８８】

【表８７】

【０１８９】

【表８８】

【０１９０】

【表８９】

【０１９１】

【表９０】

【０１９２】

【表９１】

【０１９３】

【表９２】

【０１９４】

【表９３】

【０１９５】

【表９４】

【０１９６】

【表９５】

【０１９７】

【表９６】

【０１９８】

【表９７】

【０１９９】

【表９８】

【０２００】

【表９９】

【０２０１】

【表１００】

【０２０２】

【表１０１】

【０２０３】

【表１０２】

【０２０４】

【表１０３】

【０２０５】

【表１０４】

【０２０６】

【表１０５】

【０２０７】

【表１０６】

【０２０８】

【表１０７】

【０２０９】

【表１０８】

【０２１０】

【表１０９】

【０２１１】

【表１１０】

【０２１２】

【表１１１】

【０２１３】

【表１１２】

【０２１４】

【表１１３】

【０２１５】

【表１１４】

【０２１６】

【表１１５】

【０２１７】

【表１１６】

【０２１８】

【表１１７】

【０２１９】

【表１１８】

【０２２０】

【表１１９】

【０２２１】

【表１２０】

【０２２２】

【表１２１】

【０２２３】

【表１２２】

【０２２４】

【表１２３】

【０２２５】

【表１２４】

【０２２６】

【表１２５】

【０２２７】

【表１２６】

【０２２８】

【表１２７】

【０２２９】

【表１２８】

【０２３０】

【表１２９】

【０２３１】

【表１３０】

【０２３２】

【表１３１】

【０２３３】

【表１３２】

【０２３４】

【表１３３】

【０２３５】

【表１３４】

【０２３６】

【表１３５】

【０２３７】

【表１３６】

【０２３８】

【表１３７】

【０２３９】

【表１３８】

【０２４０】

【表１３９】

【０２４１】

【表１４０】

【０２４２】

【表１４１】

【０２４３】

【表１４２】

【０２４４】

【表１４３】

【０２４５】

【表１４４】

【０２４６】

【表１４５】

【０２４７】

【表１４６】

【０２４８】

【表１４７】

【０２４９】

【表１４８】

【０２５０】

【表１４９】

【０２５１】

【表１５０】

【０２５２】

【表１５１】

【０２５３】

【表１５２】

【０２５４】

【表１５３】

【０２５５】

【表１５４】

【０２５６】

【表１５５】

【０２５７】

【表１５６】

【０２５８】

【表１５７】

【０２５９】

【表１５８】

【０２６０】

【表１５９】

【０２６１】

【表１６０】

【０２６２】

【表１６１】

【０２６３】

【表１６２】未分化のNT2細胞、RA存在下で培養したNT2
細胞、またはRA存在下で培養してさらに阻害剤を添加し
て培養したNT2細胞の各cDNAの発現（表中には実施例で
説明の無いクローンも含まれている） 表中、NT2は無処理細胞、NT2 RAはレチノイン酸処理細
胞、NT2 RA INHIBはレチノイン酸/阻害剤処理細胞を示
す。また、exp.1、exp.2、およびexp.3は、それぞれn=3
の測定結果を表している。t test N/Rは、無処理の細胞
とレチノイン酸処理細胞との有意差検定の結果を、t te
st N/Iは無処理の細胞とレチノイン酸/阻害剤処理細胞
との有意差検定の結果を示す。有意差検定の結果を、*P
<0.05、および**P<0.01で示した。

【０２６４】

【表１６３】

【０２６５】

【表１６４】

【０２６６】

【表１６５】

【０２６７】

【表１６６】

【０２６８】

【表１６７】

【０２６９】

【表１６８】

【０２７０】

【表１６９】

【０２７１】

【表１７０】

【０２７２】

【表１７１】

【０２７３】

【表１７２】

【０２７４】

【表１７３】

【０２７５】

【表１７４】

【０２７６】

【表１７５】

【０２７７】

【表１７６】

【０２７８】

【表１７７】

【０２７９】

【表１７８】

【０２８０】

【表１７９】

【０２８１】

【表１８０】

【０２８２】

【表１８１】

【０２８３】

【表１８２】

【０２８４】

【表１８３】

【０２８５】

【表１８４】

【０２８６】

【表１８５】

【０２８７】

【表１８６】

【０２８８】

【表１８７】

【０２８９】

【表１８８】

【０２９０】

【表１８９】

【０２９１】

【表１９０】

【０２９２】

【表１９１】

【０２９３】

【表１９２】

【０２９４】

【表１９３】

【０２９５】

【表１９４】

【０２９６】

【表１９５】

【０２９７】

【表１９６】

【０２９８】

【表１９７】

【０２９９】

【表１９８】

【０３００】

【表１９９】

【０３０１】

【表２００】

【０３０２】

【表２０１】

【０３０３】

【表２０２】

【０３０４】

【表２０３】

【０３０５】

【表２０４】

【０３０６】

【表２０５】

【０３０７】

【表２０６】

【０３０８】

【表２０７】

【０３０９】

【表２０８】

【０３１０】

【表２０９】

【０３１１】

【表２１０】

【０３１２】

【表２１１】

【０３１３】

【表２１２】

【０３１４】

【表２１３】

【０３１５】

【表２１４】

【０３１６】

【表２１５】

【０３１７】

【表２１６】

【０３１８】

【表２１７】

【０３１９】

【表２１８】

【０３２０】

【表２１９】

【０３２１】

【表２２０】

【０３２２】

【表２２１】

【０３２３】

【表２２２】

【０３２４】

【表２２３】

【０３２５】

【表２２４】

【０３２６】

【表２２５】

【０３２７】

【表２２６】

【０３２８】

【表２２７】

【０３２９】

【表２２８】

【０３３０】

【表２２９】

【０３３１】

【表２３０】

【０３３２】

【表２３１】

【０３３３】

【表２３２】

【０３３４】

【表２３３】

【０３３５】

【表２３４】

【０３３６】

【表２３５】

【０３３７】

【表２３６】

【０３３８】

【表２３７】

【０３３９】

【表２３８】

【０３４０】

【表２３９】

【０３４１】

【表２４０】

【０３４２】

【表２４１】

【０３４３】

【表２４２】

【０３４４】

【表２４３】

【０３４５】

【表２４４】

【０３４６】

【表２４５】

【０３４７】

【表２４６】

【０３４８】

【表２４７】

【０３４９】

【表２４８】

【０３５０】

【表２４９】

【０３５１】

【表２５０】

【０３５２】

【表２５１】

【０３５３】

【表２５２】

【０３５４】

【表２５３】

【０３５５】

【表２５４】

【０３５６】

【表２５５】

【０３５７】

【表２５６】

【０３５８】

【表２５７】

【０３５９】

【表２５８】

【０３６０】

【表２５９】

【０３６１】

【表２６０】

【０３６２】

【表２６１】

【０３６３】

【表２６２】

【０３６４】

【表２６３】

【０３６５】

【表２６４】

【０３６６】

【表２６５】

【０３６７】

【表２６６】

【０３６８】

【表２６７】

【０３６９】

【表２６８】

【０３７０】

【表２６９】

【０３７１】

【表２７０】

【０３７２】

【表２７１】

【０３７３】

【表２７２】

【０３７４】

【表２７３】

【０３７５】

【表２７４】

【０３７６】

【表２７５】

【０３７７】

【表２７６】

【０３７８】

【表２７７】

【０３７９】

【表２７８】

【０３８０】

【表２７９】

【０３８１】

【表２８０】

【０３８２】

【表２８１】

【０３８３】

【表２８２】

【０３８４】

【表２８３】

【０３８５】

【表２８４】

【０３８６】

【表２８５】

【０３８７】

【表２８６】

【０３８８】

【表２８７】

【０３８９】

【表２８８】

【０３９０】

【表２８９】

【０３９１】

【表２９０】

【０３９２】

【表２９１】

【０３９３】

【表２９２】

【０３９４】

【表２９３】

【０３９５】

【表２９４】

【０３９６】

【表２９５】

【０３９７】

【表２９６】

【０３９８】

【表２９７】

【０３９９】

【表２９８】

【０４００】

【表２９９】

【０４０１】

【表３００】

【０４０２】

【表３０１】

【０４０３】

【表３０２】

【０４０４】

【表３０３】

【０４０５】

【表３０４】

【０４０６】

【表３０５】

【０４０７】

【表３０６】

【０４０８】

【表３０７】

【０４０９】

【表３０８】

【０４１０】

【表３０９】

【０４１１】

【表３１０】

【０４１２】

【表３１１】

【０４１３】

【表３１２】

【０４１４】

【表３１３】

【０４１５】

【表３１４】

【０４１６】

【表３１５】

【０４１７】

【表３１６】

【０４１８】

【表３１７】

【０４１９】

【表３１８】

【０４２０】

【表３１９】

【０４２１】

【表３２０】

【０４２２】

【表３２１】

【０４２３】

【表３２２】

【０４２４】

【表３２３】

【０４２５】

【表３２４】

【０４２６】

【表３２５】

【０４２７】

【表３２６】

【０４２８】

【表３２７】

【０４２９】

【表３２８】

【０４３０】

【表３２９】

【０４３１】

【表３３０】

【０４３２】

【表３３１】

【０４３３】

【表３３２】

【０４３４】

【表３３３】

【０４３５】

【表３３４】

【０４３６】

【表３３５】

【０４３７】

【表３３６】

【０４３８】

【表３３７】

【０４３９】

【表３３８】

【０４４０】

【表３３９】

【０４４１】

【表３４０】

【０４４２】

【表３４１】

【０４４３】上記の表５〜表３４１に示したクローン番
号は、明細書中に示したPSECクローン番号とそれぞれ次
のように対応している。

【０４４４】実施例８．RT-PCR法を用いたNT2細胞のニ
ューロンへの分化段階におけるPSECクローンの発現頻度
解析 NT2細胞（NT2 Precursor Cells: STRATAGENE社製）の各
段階（未分化、レチノイン酸処理後１週、３週、５週、
細胞分裂阻害剤添加後、NT2ニューロン）でのtotal RNA
を調製し、PSECクローンの発現変化をRT-PCR法により調
べた。RT-PCRを行うPSECクローンについては、NT2細胞
由来cDNAライブラリー(NT2RM1, NT2RP1,NT2RP2, NT2RP
3)、あるいはヒト胎児のより脳を多く含む組織由来のcD
NAライブラリー（HEMBA1）で発現しているクローンを対
象とした。

【０４４５】NT2細胞の取扱いについては、基本的に付
属のINSTRACTION MANUALに従った。未分化NT2細胞と
は、OPTI-MEM I (GIBCO BRL社製、カタログNo.31985)、
10%(v/v) fetal bovine serum(GIBCO BRL社製)、1%(v/
v) penicillin-streptomycin(GIBCO BRL社製)の培地で
継代していたNT2細胞である。レチノイン酸処理後１
週、3週、5週のNT2細胞とは、未分化NT2細胞をD-MEM(GI
BCO BRL社製、カタログNo.11965)、10%(v/v) fetal bov
ine serum、1%(v/v) penicillin-streptomycin、10μMR
etinoic acid(GIBCO BRL社製)のレチノイン酸添加培地
に移した後、それぞれ1週、3週、5週間継代後の細胞で
ある。細胞分裂阻害剤添加後のNT2細胞とは、レチノイ
ン酸添加5週間を経たNT2細胞を細胞分裂阻害剤を添加し
た培地D-MEM(GIBCO BRL社製、カタログNo.11965)、10%
(v/v) fetal bovine serum、1%(v/v) penicillin-strep
tomycin、10μM Retinoic acid、10μM FudR(5-Fluoro-
2'-deoxyuridine：GIBCO BRL社製)、10μM Urd(Uridin
e：GIBCO BRL社製)、1μM araC(Cytosine β-D-Arabino
furanoside：GIBCO BRL社製)に移した後２週間後の細胞
である。NT2ニューロンとは細胞分裂阻害剤添加後のNT2
細胞を約10日間継代し、NT2ニューロンを弱いトリプシ
ン処理条件下で回収した細胞である。それぞれの細胞は
トリプシン処理して回収後、Rneasy Mini Kit(QIAGEN社
製)を用いて、添付のプロトコールに従いtotal RNAを調
製した。

【０４４６】RT-PCRは、各total RNAを1反応につき50ng
相当使用し、SUPERSCRIPT^TM ONE-STEP^TM RT-PCR System
(GIBCO BRL社製)を用いて行った。RT-PCRの反応条件は
基本的にSUPERSCRIPT^TM ONE-STEP^TM RT-PCR System添付
のプロトコールに従ったが、PCRの際のアニーリング温
度やサイクル数は変更した。増幅したPCR産物は反応液
の一部をアガロースゲル電気泳動にかけた。PCR産物由
来のバンドの検出にはFMBIO II Multi-View（日立製作
所社製）を用いた。NT2細胞由来cDNAライブラリー(NT2R
M1, NT2RP1, NT2RP2, NT2RP3)、あるいはヒト胎児のよ
り脳を多く含む組織由来のcDNAライブラリー（HEMBA1）
で発現している90クローンのPSECクローンについて、ま
ず未分化NT2細胞と細胞分裂阻害剤添加後のNT2細胞での
発現変化を調べた。多くのクローンでは、発現変化が顕
著でない、あるいはRT-PCRにより特異的なバンドが生じ
ないなどにより以後の解析は行わなかった。

【０４４７】上記の解析で発現変化が期待されたPSECク
ローンについて、未分化、レチノイン酸処理後1,3,5 週
での経時的発現、さらにNT2 ニューロンでの発現を調べ
た結果、PSEC0005, PSEC0048, PSEC0059, PSEC0200, PS
EC0232においてPCR産物の差が見られた（図４、５）。
一方でPSEC0001, PSEC0029, PSEC0031, PSEC0078, PSEC
0099, PSEC0173, PSEC0197, PSEC0198, PSEC0213, PSEC
0214, PSEC0260は顕著な発現変化が見られなかった。あ
る反応条件下（図中に記載）でRT-PCRにより生成された
バンドの濃度の比は図６のような変化を示した。PSEC00
05は配列番号355と配列番号356、PSEC0048は配列番号35
7と配列番号358、PSEC0059は配列番号359と配列番号36
0、PSEC0200は配列番号361と配列番号362、PSEC0232は
配列番号363と配列番号364で示すプライマーを用いてRT
-PCRを行った（PCRの際のアニーリング温度やサイクル
数は図4、図5中に記載の通り）。また、コントロールと
して使用したβアクチンは配列番号365と配列番号366、
ニューロンでの強い発現が知られているprostaglandin
D2synthase（Neuroscience, 69, 967-975(1995), Eur.
J. Neurosci. 9, 1566-1573(1997)）については、公知
になっているGenBnak Accession No. M61900にある配列
と塩基配列レベルでもアミノ酸配列レベルでも94％以上
同一でNT2細胞由来のcDNAライブラリーから得られたcDN
A（配列番号367）をもとに設計した配列番号368と配列
番号369で示すプライマーを用いてRT-PCRを行った（PCR
の際のアニーリング温度やサイクル数は図4、図5中に記
載の通り）。

【０４４８】PSEC0232はNT2ニューロン分化とともに強
い発現が見られる、ニューロン分化と関連がある重要な
遺伝子であることがわかった。PSEC0048, PSEC0200はNT
2ニューロンで弱い発現しか見られなかったが、分化途
中の段階で発現増大が見られたため、ニューロン分化と
関連がある遺伝子であることがわかった。またPSEC0059
もNT2ニューロンで発現はみられなかったものの、分化
途中の段階で顕著な発現増大が見られたため、ニューロ
ン分化と関連がある遺伝子であることがわかった。PSEC
0005は分化途中の段階で明らかな発現減少が見られた。
他の遺伝子とは挙動が異なるが、この遺伝子もニューロ
ン分化と何らかの関連がある遺伝子であることがわかっ
た。

【０４４９】実施例７で同様に行った高密度DNAフィル
ターを用いた、ハイブリダイゼーションによる神経細胞
分化関連遺伝子の解析結果との比較では、３クローン
（PSEC0048;NT2RP2000028, PSEC0059;NT2RP2000601, PS
EC0200;HEMBA1001879）で同様の結果を示した。RT-PCR
法とハイブリダイゼーション解析とで必ずしも解析結果
が一致していない点については、RT-PCR法を試みたが、
特異的なバンドが生じないなどによりRT-PCR法による解
析ができなかった。あるいは、ハイブリダイゼーション
解析で検出されたシグナルが弱く、発現変化の判定がむ
ずかしいクローンであったことが原因と考えられた。

【０４５０】

【表３４２】本発明のPSEC cDNAクローンにおける5'側
と3'側を規定する塩基配列を示す配列番号と、そのポリ
ヌクレオチドをインサートとして含む実施例で取得した
プラスミドクローンの対応関係を示す。同一クローンで
5'末端配列に対応する3'末端配列が決定されていないも
のは空欄とした。5'配列 配列名の右側が5'配列の配列
番号であり、3'配列 配列名の右側が3'配列の配列番号
である。 ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ PSEC クローン名 5'末端配列 5'末端 3'末端 3'末端 クローン名 配列名 配列 配列 配列 配列番号 配列名 配列番号 ─────────────────────────────────── PSEC0001 NT2RM1000066 F-NT2RM1000066 370 nnnnnnnn nnnnnnnnnnnn F-nnnnnnnnnnnn 371 PSEC0005 NT2RM1000566 F-NT2RM1000566 372 PSEC0007 NT2RM1000634 F-NT2RM1000634 373 PSEC0008 NT2RM1000726 F-NT2RM1000726 374 PSEC0012 NT2RM1000853 F-NT2RM1000853 375 PSEC0017 NT2RM1001103 F-NT2RM1001103 376 PSEC0019 NT2RP1000125 F-NT2RP1000125 377 PSEC0020 NT2RP1000255 F-NT2RP1000255 378 PSEC0021 NT2RP1000279 F-NT2RP1000279 379 PSEC0027 NT2RP1000477 F-NT2RP1000477 380 PSEC0028 NT2RP1000533 F-NT2RP1000533 381 PSEC0029 NT2RP1000544 F-NT2RP1000544 382 PSEC0030 NT2RP1000567 F-NT2RP1000567 383 PSEC0031 NT2RP1000593 F-NT2RP1000593 384 PSEC0035 NT2RP1000769 F-NT2RP1000769 385 PSEC0038 NT2RP1000837 F-NT2RP1000837 386 PSEC0040 NT2RP1000905 F-NT2RP1000905 387 PSEC0041 NT2RP1000921 F-NT2RP1000921 388 PSEC0045 NT2RP1001023 F-NT2RP1001023 389 PSEC0047 NT2RP1001042 F-NT2RP1001042 390 PSEC0048 NT2RP2000028 F-NT2RP2000028 391 R-NT2RP2000028 541 PSEC0049 NT2RP2000116 F-NT2RP2000116 392 R-NT2RP2000116 542 PSEC0051 NT2RP2000168 F-NT2RP2000168 393 R-NT2RP2000168 543 PSEC0052 NT2RP2000279 F-NT2RP2000279 394 R-NT2RP2000279 544 PSEC0053 NT2RP2000396 F-NT2RP2000396 395 R-NT2RP2000396 545 PSEC0055 NT2RP2000557 F-NT2RP2000557 396 R-NT2RP2000557 546 PSEC0059 NT2RP2000601 F-NT2RP2000601 397 R-NT2RP2000601 547 PSEC0061 NT2RP2000720 F-NT2RP2000720 398 R-NT2RP2000720 548 PSEC0066 NT2RP2001087 F-NT2RP2001087 399 PSEC0068 NT2RP2001270 F-NT2RP2001270 400 R-NT2RP2001270 549 PSEC0069 NT2RP2001341 F-NT2RP2001341 401 R-NT2RP2001341 550 PSEC0070 NT2RP2001508 F-NT2RP2001508 402 R-NT2RP2001508 551 PSEC0071 NT2RP2002115 F-NT2RP2002115 403 R-NT2RP2002115 552 PSEC0072 NT2RP2002429 F-NT2RP2002429 404 R-NT2RP2002429 553 PSEC0073 NT2RP2002934 F-NT2RP2002934 405 R-NT2RP2002934 554 PSEC0074 NT2RP2003050 F-NT2RP2003050 406 R-NT2RP2003050 555 PSEC0075 NT2RP2003227 F-NT2RP2003227 407 R-NT2RP2003227 556 PSEC0076 NT2RP2003471 F-NT2RP2003471 408 R-NT2RP2003471 557 PSEC0077 NT2RP2003902 F-NT2RP2003902 409 R-NT2RP2003902 558 PSEC0079 NT2RP2004049 F-NT2RP2004049 410 PSEC0080 NT2RP2004076 F-NT2RP2004076 411 PSEC0081 NT2RP2004130 F-NT2RP2004130 412 R-NT2RP2004130 559 PSEC0082 NT2RP2004966 F-NT2RP2004966 413 R-NT2RP2004966 560 PSEC0085 NT2RP2006476 F-NT2RP2006476 414 R-NT2RP2006476 561 PSEC0086 PLACE1000456 F-PLACE1000456 415 R-PLACE1000456 562 PSEC0087 PLACE1001022 F-PLACE1001022 416 R-PLACE1001022 563 PSEC0088 PLACE1001098 F-PLACE1001098 417 R-PLACE1001098 564 PSEC0090 PLACE1001300 F-PLACE1001300 418 R-PLACE1001300 565 PSEC0092 NT2RP2000358 F-NT2RP2000358 419 R-NT2RP2000358 566 PSEC0094 NT2RP2001499 F-NT2RP2001499 420 R-NT2RP2001499 567 PSEC0095 NT2RP2001768 F-NT2RP2001768 421 R-NT2RP2001768 568 PSEC0098 NT2RP2002695 F-NT2RP2002695 422 R-NT2RP2002695 569 PSEC0099 NT2RP2002907 F-NT2RP2002907 423 PSEC0100 NT2RP2002927 F-NT2RP2002927 424 PSEC0101 NT2RP2003115 F-NT2RP2003115 425 R-NT2RP2003115 570 PSEC0103 NT2RP2004755 F-NT2RP2004755 426 R-NT2RP2004755 571 PSEC0104 NT2RP2004795 F-NT2RP2004795 427 R-NT2RP2004795 572 PSEC0105 NT2RP2004974 F-NT2RP2004974 428 R-NT2RP2004974 573 PSEC0106 NT2RP2005219 F-NT2RP2005219 429 R-NT2RP2005219 574 PSEC0107 NT2RP2005322 F-NT2RP2005322 430 R-NT2RP2005322 575 PSEC0108 NT2RP2005670 F-NT2RP2005670 431 R-NT2RP2005670 576 PSEC0109 NT2RP2005671 F-NT2RP2005671 432 R-NT2RP2005671 577 PSEC0110 PLACE1010021 F-PLACE1010021 433 R-PLACE1010021 578 PSEC0111 NT2RP2006028 F-NT2RP2006028 434 PSEC0112 NT2RP2006400 F-NT2RP2006400 435 PSEC0113 NT2RP2006435 F-NT2RP2006435 436 R-NT2RP2006435 579 PSEC0117 PLACE1001904 F-PLACE1001904 437 R-PLACE1001904 580 PSEC0119 PLACE1002376 F-PLACE1002376 438 R-PLACE1002376 581 PSEC0120 PLACE1002379 F-PLACE1002379 439 R-PLACE1002379 582 PSEC0121 PLACE1003085 F-PLACE1003085 440 R-PLACE1003085 583 PSEC0124 PLACE1003378 F-PLACE1003378 441 R-PLACE1003378 584 PSEC0125 PLACE1003405 F-PLACE1003405 442 R-PLACE1003405 585 PSEC0126 PLACE1003549 F-PLACE1003549 443 R-PLACE1003549 586 PSEC0127 PLACE1003724 F-PLACE1003724 444 R-PLACE1003724 587 PSEC0128 PLACE1004113 F-PLACE1004113 445 R-PLACE1004113 588 PSEC0129 PLACE1004170 F-PLACE1004170 446 R-PLACE1004170 589 PSEC0130 PLACE1004273 F-PLACE1004273 447 R-PLACE1004273 590 PSEC0131 PLACE1004322 F-PLACE1004322 448 R-PLACE1004322 591 PSEC0133 PLACE1004507 F-PLACE1004507 449 R-PLACE1004507 592 PSEC0134 PLACE1004757 F-PLACE1004757 450 R-PLACE1004757 593 PSEC0135 PLACE1004850 F-PLACE1004850 451 R-PLACE1004850 594 PSEC0136 PLACE1004904 F-PLACE1004904 452 R-PLACE1004904 595 PSEC0137 PLACE1005047 F-PLACE1005047 453 R-PLACE1005047 596 PSEC0139 PLACE1005760 F-PLACE1005760 454 PSEC0142 PLACE1006269 F-PLACE1006269 455 R-PLACE1006269 597 PSEC0143 PLACE1006472 F-PLACE1006472 456 R-PLACE1006472 598 PSEC0144 PLACE1006610 F-PLACE1006610 457 R-PLACE1006610 599 PSEC0147 PLACE1007190 F-PLACE1007190 458 R-PLACE1007190 600 PSEC0149 PLACE1007338 F-PLACE1007338 459 R-PLACE1007338 601 PSEC0150 PLACE1007635 F-PLACE1007635 460 R-PLACE1007635 602 PSEC0151 PLACE1007878 F-PLACE1007878 461 R-PLACE1007878 603 PSEC0152 PLACE1007885 F-PLACE1007885 462 R-PLACE1007885 604 PSEC0158 PLACE1008738 F-PLACE1008738 463 R-PLACE1008738 605 PSEC0159 PLACE1008994 F-PLACE1008994 464 R-PLACE1008994 606 PSEC0161 PLACE1009580 F-PLACE1009580 465 R-PLACE1009580 607 PSEC0162 PLACE1009772 F-PLACE1009772 466 R-PLACE1009772 608 PSEC0163 PLACE1010330 F-PLACE1010330 467 R-PLACE1010330 609 PSEC0164 PLACE1010482 F-PLACE1010482 468 R-PLACE1010482 610 PSEC0165 PLACE1010978 F-PLACE1010978 469 R-PLACE1010978 611 PSEC0167 PLACE1011134 F-PLACE1011134 470 R-PLACE1011134 612 PSEC0168 PLACE1011146 F-PLACE1011146 471 R-PLACE1011146 613 PSEC0169 PLACE1011360 F-PLACE1011360 472 R-PLACE1011360 614 PSEC0170 PLACE1011386 F-PLACE1011386 473 R-PLACE1011386 615 PSEC0171 PLACE1011514 F-PLACE1011514 474 R-PLACE1011514 616 PSEC0172 PLACE1011835 F-PLACE1011835 475 R-PLACE1011835 617 PSEC0173 NT2RP2000428 F-NT2RP2000428 476 R-NT2RP2000428 618 PSEC0178 OVARC1000636 F-OVARC1000636 477 R-OVARC1000636 619 PSEC0181 OVARC1001499 F-OVARC1001499 478 R-OVARC1001499 620 PSEC0182 OVARC1001636 F-OVARC1001636 479 R-OVARC1001636 621 PSEC0183 OVARC1001849 F-OVARC1001849 480 R-OVARC1001849 622 PSEC0190 HEMBA1000296 F-HEMBA1000296 481 R-HEMBA1000296 623 PSEC0191 HEMBA1000446 F-HEMBA1000446 482 R-HEMBA1000446 624 PSEC0192 HEMBA1000675 F-HEMBA1000675 483 R-HEMBA1000675 625 PSEC0195 HEMBA1001322 F-HEMBA1001322 484 R-HEMBA1001322 626 PSEC0197 HEMBA1001490 F-HEMBA1001490 485 R-HEMBA1001490 627 PSEC0198 HEMBA1001552 F-HEMBA1001552 486 R-HEMBA1001552 628 PSEC0199 HEMBA1001680 F-HEMBA1001680 487 R-HEMBA1001680 629 PSEC0200 HEMBA1001879 F-HEMBA1001879 488 R-HEMBA1001879 630 PSEC0203 HEMBA1002441 F-HEMBA1002441 489 R-HEMBA1002441 631 PSEC0204 HEMBA1002706 F-HEMBA1002706 490 R-HEMBA1002706 632 PSEC0205 HEMBA1002715 F-HEMBA1002715 491 PSEC0206 HEMBA1002913 F-HEMBA1002913 492 R-HEMBA1002913 633 PSEC0207 HEMBA1002981 F-HEMBA1002981 493 R-HEMBA1002981 634 PSEC0209 HEMBA1003280 F-HEMBA1003280 494 R-HEMBA1003280 635 PSEC0210 HEMBA1003702 F-HEMBA1003702 495 R-HEMBA1003702 636 PSEC0212 HEMBA1003764 F-HEMBA1003764 496 R-HEMBA1003764 637 PSEC0213 HEMBA1004078 F-HEMBA1004078 497 R-HEMBA1004078 638 PSEC0214 HEMBA1004100 F-HEMBA1004100 498 R-HEMBA1004100 639 PSEC0215 HEMBA1004149 F-HEMBA1004149 499 R-HEMBA1004149 640 PSEC0216 HEMBA1004633 F-HEMBA1004633 500 R-HEMBA1004633 641 PSEC0218 HEMBA1005096 F-HEMBA1005096 501 R-HEMBA1005096 642 PSEC0220 HEMBA1005301 F-HEMBA1005301 502 PSEC0222 HEMBA1005452 F-HEMBA1005452 503 PSEC0223 HEMBA1005628 F-HEMBA1005628 504 R-HEMBA1005628 643 PSEC0224 HEMBA1005703 F-HEMBA1005703 505 R-HEMBA1005703 644 PSEC0226 HEMBA1005833 F-HEMBA1005833 506 R-HEMBA1005833 645 PSEC0227 HEMBA1006019 F-HEMBA1006019 507 R-HEMBA1006019 646 PSEC0228 HEMBA1006099 F-HEMBA1006099 508 R-HEMBA1006099 647 PSEC0230 HEMBA1006391 F-HEMBA1006391 509 R-HEMBA1006391 648 PSEC0232 HEMBA1006549 F-HEMBA1006549 510 R-HEMBA1006549 649 PSEC0233 HEMBA1006813 F-HEMBA1006813 511 R-HEMBA1006813 650 PSEC0235 HEMBA1007053 F-HEMBA1007053 512 R-HEMBA1007053 651 PSEC0236 HEMBA1007104 F-HEMBA1007104 513 R-HEMBA1007104 652 PSEC0239 OVARC1000363 F-OVARC1000363 514 R-OVARC1000363 653 PSEC0240 OVARC1001510 F-OVARC1001510 515 R-OVARC1001510 654 PSEC0241 NT2RP3000234 F-NT2RP3000234 516 R-NT2RP3000234 655 PSEC0242 NT2RP3000266 F-NT2RP3000266 517 R-NT2RP3000266 656 PSEC0243 NT2RP3000326 F-NT2RP3000326 518 R-NT2RP3000326 657 PSEC0244 NT2RP3000638 F-NT2RP3000638 519 R-NT2RP3000638 658 PSEC0245 NT2RP3000719 F-NT2RP3000719 520 R-NT2RP3000719 659 PSEC0246 NT2RP3001359 F-NT2RP3001359 521 R-NT2RP3001359 660 PSEC0247 NT2RP3001613 F-NT2RP3001613 522 R-NT2RP3001613 661 PSEC0248 NT2RP3001619 F-NT2RP3001619 523 R-NT2RP3001619 662 PSEC0249 NT2RP3001861 F-NT2RP3001861 524 R-NT2RP3001861 663 PSEC0250 NT2RP3001874 F-NT2RP3001874 525 R-NT2RP3001874 664 PSEC0251 NT2RP3003097 F-NT2RP3003097 526 R-NT2RP3003097 665 PSEC0252 NT2RP3003258 F-NT2RP3003258 527 R-NT2RP3003258 666 PSEC0253 NT2RP3003368 F-NT2RP3003368 528 R-NT2RP3003368 667 PSEC0255 NT2RP3003536 F-NT2RP3003536 529 R-NT2RP3003536 668 PSEC0256 NT2RP3003549 F-NT2RP3003549 530 R-NT2RP3003549 669 PSEC0258 NT2RP3003731 F-NT2RP3003731 531 R-NT2RP3003731 670 PSEC0259 NT2RP3003789 F-NT2RP3003789 532 R-NT2RP3003789 671 PSEC0260 NT2RP3004059 F-NT2RP3004059 533 R-NT2RP3004059 672 PSEC0261 NT2RP3004063 F-NT2RP3004063 534 R-NT2RP3004063 673 PSEC0263 NT2RP3004541 F-NT2RP3004541 535 R-NT2RP3004541 674 PSEC0078 NT2RP2004036 F-NT2RP2004036 536 R-NT2RP2004036 675 PSEC0084 NT2RP2005970 F-NT2RP2005970 537 R-NT2RP2005970 676 PSEC0237 HEMBA1007186 F-HEMBA1007186 538 R-HEMBA1007186 677 PSEC0264 NT2RP3002337 F-NT2RP3002337 539 R-NT2RP3002337 678 PSEC0265 NT2RP3003235 F-NT2RP3003235 540 R-NT2RP3003235 679 ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

【０４５１】

【表３４３】滑膜細胞、TNF存在下で培養した滑膜細胞
の各cDNAの発現（表中には実施例で説明の無いクローン
も含まれている） 表中、Synoviocyteは滑膜細胞を、Syoviocute_TNFはTNF
処理した滑膜細胞を示す。また、exp1、exp2、およびex
p3は、それぞれn=3の測定結果を表している。ttest vs
TNFは、滑膜細胞とTNF処理した滑膜細胞との有意差検定
の結果を示す。TNF処理した滑膜細胞における発現量の
増加を＋で、減少を−で増減として示す。有意差検定の
結果を、*P<0.05、および**P<0.01で示した。 ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Clone Synoviocyte Synoviocute_TNF t test ────────────────────── vs 増減 exp.1 exp.2 exp.3 exp.1 exp.2 exp.3 TNF ────────────────────────────────── GAPDH(Cr1) 0.4 0.8 0.89 0.9 1 1.15 βactin(Cr2) 385.94 262.23 582.98 443.28 422.61 573.47 ADRGL1000005 2.72 2.97 4.46 7.27 7.45 3.51 ADRGL1000007 4.36 5.19 9.58 20.78 19.59 18.29 ** + ADRGL1000009 0.99 1.25 1.64 2.16 4.08 2.02 ADRGL1000011 1.98 3.56 5.24 22.22 23.49 19.81 ** + ADRGL1000027 0.79 1.22 1.66 2.82 4.99 1.9 ADRGL1000058 4.12 7.08 26.9 62.55 67.32 49.15 ** + ADRGL1000069 1.91 1.68 2.47 14.19 14.54 13.74 ** + ADRGL1000077 1.98 2 2.54 5.5 2.9 4.16 ADRGL1000092 2.99 4.79 12.53 21.46 22.09 26.19 ** + ADRGL1000099 2.77 4.79 12.85 23.61 24.02 25.56 ** + ADRGL1000136 20.49 27.18 31.85 62.44 40.69 48.29 * + ADRGL1000147 2.09 2.58 5.47 5.69 7.52 3.85 ADRGL1000159 1.51 1.77 3.07 3.4 4.71 2.59 ADRGL1000160 2.42 4.34 6.89 8.08 7.24 7.06 ADRGL1000171 0.95 1.11 1.64 1.89 2.69 1.87 ADRGL1000181 0.64 1.37 1.74 3.99 4.27 3.89 ** + BGGI11000015 2.13 3.89 5.02 10.49 11.35 9.14 ** + BGGI11000016 27.77 35.71 52.17 57.18 48.51 63.57 BGGI11000017 1.29 3.19 3.14 3.24 3.65 2.34 BGGI11000022 4.72 4.45 6.75 10.71 5.56 8.27 BGGI11000031 4.47 6.58 8.77 14.79 11.63 10.04 * + BGGI11000042 9.55 11.29 20.54 23.39 18.75 20.23 BGGI11000046 8.56 9.77 17.04 34.24 30.76 25.79 ** + BNGH41000020 246.16 211.77 380.83 658.32 647.37 559.16 ** + BNGH41000025 4.31 3.12 6.92 11.4 13.1 15.01 ** + BNGH41000026 2.71 4.77 7.53 4.45 7.17 6.23 BNGH41000027 11.52 13.5 12.69 20.62 12.48 24.91 BNGH41000035 23.02 25.91 36.46 51.05 31.83 41.67 BNGH41000037 2.7 5.21 6.72 12.95 8.98 8.59 * + BNGH41000042 14.55 16.06 22.84 49.62 37.57 36.25 ** + BNGH41000048 3.92 6.27 25.68 66.19 74.4 66.21 ** + BNGH41000056 0.74 1.75 3.26 5.28 7.34 3.75 * + BNGH41000087 3.36 4.08 5.19 5.59 8.15 3.01 BNGH41000091 0.18 1.45 2.47 2.72 3.4 2.14 BNGH41000157 6.93 7.99 6.23 13.37 10.28 9.98 * + BNGH41000169 1.09 1.53 2.99 2.77 4.23 2.59 BNGH41000181 3.5 4.06 7.5 5.71 6.81 6.09 BNGH41000198 1.32 2.3 4.35 2.06 2.55 2.22 BNGH41000219 2.29 3.91 5.61 12.4 13.73 10.76 ** + BNGH41000229 9.65 9.99 12.99 18.34 18.92 18.94 ** + BNGH41000237 8.4 12.99 12.61 27.63 11.26 13.45 BNGH41000238 1.56 2.59 6.77 3.45 4.55 3.32 BNGH41000243 5.56 8.95 6.71 15.03 12.55 16.36 ** + BNGH41000270 2.94 2.77 2.88 3.67 3.99 3.74 ** + BRAWH1000004 1 2.19 6.99 6.45 8.36 6 BRAWH1000018 1.8 2.24 5.06 4.43 6.95 5.24 BRAWH1000021 1.33 2.73 4.81 4.16 5.85 5.21 BRAWH1000027 0.58 1.7 1.62 2.39 3.65 2.63 * + BRAWH1000029 2.32 3.63 6.21 6.03 6.73 4.81 BRAWH1000040 4.68 4.98 8.01 7.28 7.2 8.67 BRAWH1000050 11.04 10.47 43.79 51.7 73.7 60.92 * + BRAWH1000051 2.14 0.63 2.71 2.25 4.43 1.04 BRAWH1000060 7.84 8.07 48.26 59.16 66.12 63.86 * + BRAWH1000075 1.85 1.86 2.98 2.07 4.4 2.34 BRAWH1000081 1.88 2.78 7.19 5.9 10.82 7.4 BRAWH1000084 30.23 30.57 65.21 235.81 180.86 211.35 ** + BRAWH1000095 1.38 2.47 4.51 3 4.78 2.67 BRAWH1000096 1.37 2.89 4.71 3.7 4.8 5.17 BRAWH1000097 3.32 3.27 10.74 9.24 10.62 7.75 BRAWH1000100 4.77 5.19 7.69 6.98 7.06 7.28 BRAWH1000101 12 12.04 36.52 46.19 41.09 50.21 * + BRAWH1000104 1.37 0.92 4.33 1.47 4.47 2.41 BRAWH1000107 0.62 1.88 2.48 2.43 5.03 3.15 BRAWH1000110 4.4 4.06 16.81 13.87 11.1 15.74 BRAWH1000111 3.98 6.14 6.05 8.85 8.95 10.64 * + BRAWH1000135 4.95 4.91 7.7 7.37 9.42 9.98 BRAWH1000190 2.22 3.84 5.07 4.66 7.16 4.99 HEMBA1000005 5.91 6.44 11.97 17.55 22.88 18.65 * + HEMBA1000006 2.61 3.17 4.64 3.08 8.49 4.75 HEMBA1000012 10.97 11.75 51.07 71.4 106.82 74.8 * + HEMBA1000020 50.65 49.12 113.3 197.41 293.79 216.89 * + HEMBA1000030 1.93 3.08 4.67 5.72 3.62 6.43 HEMBA1000034 3.27 3.21 5.35 4.62 10.29 6.85 HEMBA1000042 1.64 3.17 6 4.72 6.92 8.12 HEMBA1000045 7.13 9.44 11.07 9.55 14.43 10.44 HEMBA1000046 1.14 2.24 2.77 3.73 5.3 4.34 * + HEMBA1000047 1.17 1.99 3.83 2.98 4.47 3.78 HEMBA1000048 3.76 4.75 3.64 8.73 12.38 5.48 HEMBA1000050 0.48 1.77 1.78 1.4 3.39 1.46 HEMBA1000053 1.64 1.28 2.57 4.68 4.03 3.99 ** + HEMBA1000060 1.88 2.71 4.51 7.29 7.94 9.74 ** + HEMBA1000072 52.79 53.46 135.73 165.97 221.75 230.97 * + HEMBA1000073 16.54 11.43 27.32 22.4 36.09 33.78 HEMBA1000076 5.06 5.33 9.77 12.16 10.46 11.15 * + HEMBA1000084 4.75 4.46 20.71 30.15 43.67 33.92 * + HEMBA1000087 0.51 1 3.32 0.65 2.82 1.61 HEMBA1000088 1.98 2.97 4.6 6.2 9.87 8.46 * + HEMBA1000091 6.36 5.4 17.56 30.15 44.04 35.43 ** + HEMBA1000111 1.52 1.77 3.63 5.29 6.65 6.4 ** + HEMBA1000121 0.86 1.17 3.58 3.52 4.47 5.83 HEMBA1000128 1.52 2.99 6.04 4.28 6.05 5.93 HEMBA1000129 2.04 1.81 3.95 2.66 3.26 3.32 HEMBA1000141 2.31 3.45 5.98 3.56 6.67 5.6 HEMBA1000146 0.84 1.29 2.96 1.93 4.98 3.52 HEMBA1000150 3.34 3.29 10.65 8.27 11.97 9.46 HEMBA1000154 25.17 29.21 82.33 128.3 134.42 139.59 ** + HEMBA1000156 3.28 4 5.87 8.69 6.19 6.13 HEMBA1000158 7.98 10.04 12.52 16.99 15.47 12.88 HEMBA1000168 1.21 2.2 4.11 5.7 7.3 5.21 * + HEMBA1000180 0.4 2.04 2.87 2.86 4.06 2.05 HEMBA1000185 1.65 3.84 4.88 7.5 9.46 9.07 ** + HEMBA1000188 1.37 1.64 3.31 4.94 4.19 3.35 HEMBA1000193 1.53 0.66 3.16 2.68 4.33 2.5 HEMBA1000194 2.18 2.95 5.68 9.11 8.74 8.83 ** + HEMBA1000201 2.6 4.47 9.74 13.45 14.8 14.65 * + HEMBA1000213 1.33 1.95 2.76 2.08 4.49 3.7 HEMBA1000216 1.26 1.82 3.27 2.92 5.2 3.47 HEMBA1000227 0.99 2.27 2.38 3.28 4.21 1.83 HEMBA1000231 1.5 1.97 5 7.56 7.19 6.16 * + HEMBA1000237 4.5 6.13 9.14 14.79 18.3 14.71 ** + HEMBA1000243 0.6 1.89 3.01 4.3 4.34 3.67 * + HEMBA1000244 1.54 2.45 3.78 6.08 5.58 3.36 HEMBA1000251 1.15 1.92 2.97 2.26 4.59 3.22 HEMBA1000254 0.69 1.8 4.81 3.57 4.97 3.58 HEMBA1000264 0.84 2.28 3.01 2.84 3.23 3.12 HEMBA1000269 1.9 2.34 3.69 4.41 4.09 2.51 HEMBA1000275 5.31 4.29 8.03 7.96 12.04 8.54 HEMBA1000280 1.43 0.83 2.19 3.3 4.08 4 ** + HEMBA1000282 1.15 1.01 4.23 6.29 7.01 5.46 * + HEMBA1000287 2.86 3.19 4.45 5.81 6.04 6.37 ** + HEMBA1000288 1.37 2.23 6.13 3.51 6.02 3.85 HEMBA1000290 1.01 2.17 4.11 2.46 3.26 2.73 HEMBA1000296 2.4 3.66 5.49 6.15 6.55 5.84 HEMBA1000300 1.22 2.73 6.6 7.64 8.88 7.23 HEMBA1000302 0.93 2.17 2.86 3.04 3.74 1.97 HEMBA1000303 1.36 2.15 3.57 4.13 4.43 3 HEMBA1000304 1.06 1.99 4.26 5.51 7.28 4.87 * + HEMBA1000307 1.21 1.73 2.65 4.4 5.64 2.99 * + HEMBA1000312 6 8.7 10.77 13.2 9.18 9.65 HEMBA1000318 1.5 4.22 3.25 5.39 6.05 4.49 HEMBA1000327 2.18 3.7 3.34 10.58 6.06 6.02 * + HEMBA1000333 0.68 2.75 4.33 3.12 4.74 2.98 HEMBA1000338 1.61 2.84 5.33 5.8 5.78 4.32 HEMBA1000343 1.79 3.5 3.69 5.55 6.7 3.99 HEMBA1000349 0.97 1.52 3.24 3.9 5.37 4.09 * + HEMBA1000351 1.6 2.06 5.75 4.8 6.22 5.24 HEMBA1000355 1.52 3.09 4.09 3.78 5.14 3.59 HEMBA1000356 9.3 10.42 14.39 26.93 22.26 24.97 ** + HEMBA1000357 1.88 2.11 4.76 3.81 5.7 4.62 HEMBA1000366 1.67 1.94 3.83 3.14 4.75 3.28 HEMBA1000369 1.87 2.94 5.17 2.82 5.2 4.56 HEMBA1000370 2.45 3.4 4.63 3.75 5.34 3.6 HEMBA1000376 3.64 4.55 14.48 26.69 29.98 28.36 ** + HEMBA1000387 2.95 3.19 6.2 7.85 7.62 8.15 * + HEMBA1000389 2.88 3.74 8.83 14.4 10.9 13.61 * + HEMBA1000390 1.86 2.27 3.5 4.28 4.98 3.95 * + HEMBA1000392 1.49 1.4 3.06 2.58 3.78 1.94 HEMBA1000396 1.82 2.16 3.45 3.43 4.93 3.34 HEMBA1000411 1.01 1.41 4.49 1.94 4.41 2.21 HEMBA1000418 2.85 3.21 4.41 7.75 6.81 5.17 * + HEMBA1000422 0.99 1.89 2.14 2.64 4.03 2.89 HEMBA1000428 0.36 2.43 3.09 2.58 3.31 2.75 HEMBA1000434 0.54 2.19 2.93 2.11 3.6 2.69 HEMBA1000442 0.82 2.2 3.37 2.13 3.8 2.28 HEMBA1000443 1.19 1.9 3.12 2.99 6.28 3.59 HEMBA1000446 38.48 43.56 75.05 56.34 60.86 69.87 HEMBA1000456 5.19 4.41 6.5 7.45 5.62 8.77 HEMBA1000459 1.95 2.11 4.24 3.46 6.17 5.55 HEMBA1000460 7.46 7.84 8.87 13.59 12.54 18.45 * + HEMBA1000462 2.11 3.51 5.04 6.05 5.16 7.49 HEMBA1000464 1.33 0.96 1.73 1.69 2.74 2.53 HEMBA1000468 1.25 1.44 2.43 1.69 3.48 2.22 HEMBA1000469 2.89 3.37 8.1 5.42 8.81 8.01 HEMBA1000477 2.87 3.03 7.4 5.41 9.68 6.83 HEMBA1000481 29.67 31.97 31.95 42.76 52.75 25.82 HEMBA1000488 1.75 2.43 2.96 3.11 5.9 3 HEMBA1000490 1.34 2 3.49 4.41 3.7 2.88 HEMBA1000491 1.21 1.71 2.85 4.24 4.99 5.97 * + HEMBA1000498 2.12 3.21 4.55 4.39 7.76 5.94 HEMBA1000501 2.22 3.36 6.25 6.44 8.93 9.74 * + HEMBA1000504 2.93 3.18 4.82 3.63 5.37 3.83 HEMBA1000505 0.81 1.97 3.33 2.72 5.1 3.58 HEMBA1000507 1.02 2.24 5.29 4.17 8.62 7 HEMBA1000508 2.25 2.3 7.65 4.84 8.57 6.64 HEMBA1000518 1.38 0.96 0.98 1.89 2.97 1.8 * + HEMBA1000519 9.5 7.28 15.97 19.28 20.99 19.72 * + HEMBA1000520 0.45 1.12 1.18 1.94 4.83 4.3 * + HEMBA1000523 2.32 1.88 3.22 3.48 5.33 3.65 HEMBA1000531 1.39 1.46 2.44 2.67 5.34 4.63 * + HEMBA1000534 0.55 0.95 2.97 6.63 11.62 10.39 ** + HEMBA1000538 0.51 1.08 2.31 12.58 21.02 13.18 ** + HEMBA1000540 2.8 3.11 6.06 5.82 10.38 6.39 HEMBA1000542 9.16 7.79 43.94 62.25 95.7 81.15 * + HEMBA1000545 1.51 2.31 1.65 3.19 4.29 3.7 ** + HEMBA1000547 2.99 3.12 4.94 4.94 5.3 4.97 HEMBA1000551 2.32 1.99 9.54 4.68 7.33 9.81 HEMBA1000555 3.81 3.23 6.39 5.03 6.43 8.08 HEMBA1000557 2.16 2.06 6.07 3.98 6.46 5.06 HEMBA1000561 1.71 2.9 4.9 1.63 4.39 3.67 HEMBA1000563 1.73 1.85 4.09 2.72 3.94 2.83 HEMBA1000567 1.02 1.01 1.67 1.21 2.59 1.92 HEMBA1000568 2.19 2.5 6.09 7.62 6.65 6.84 HEMBA1000569 1.3 2.8 3.02 2.18 6.47 2.3 HEMBA1000575 3.73 4.91 10.84 10.19 15.17 13.08 HEMBA1000588 1.75 2.49 4.16 3.12 5.5 3.83 HEMBA1000590 0.59 1.02 2.06 2.24 2.53 1.35 HEMBA1000591 3.17 3.3 5.18 10.84 12.16 9.8 ** + HEMBA1000592 4.2 5.19 7.77 13.85 14.94 11.78 ** + HEMBA1000594 1.95 1.97 3.16 4 5.86 4.94 * + HEMBA1000604 1.19 3.37 3.48 5.41 10.91 5.29 HEMBA1000607 2.83 5.09 12.7 15.52 18.13 20.66 * + HEMBA1000608 0.9 2.34 2.46 2.6 5.5 2.31 HEMBA1000622 0.96 2.19 3.55 3.61 5.24 3.8 HEMBA1000634 17.56 22.96 30.36 71.62 60.59 51.59 ** + HEMBA1000636 4.59 3.95 6.78 15.48 12.35 12.73 ** + HEMBA1000637 0.93 0.48 2.58 2.42 3.19 2.21 HEMBA1000655 1.33 2.11 4.84 6.91 5.57 6.31 * + HEMBA1000657 1.35 1.78 3.24 4.89 5.28 3.26 * + HEMBA1000662 1.3 2.42 2.73 2.52 3.78 2.72 HEMBA1000664 0.94 1.6 2.87 3.11 4.63 2.94 HEMBA1000671 2.96 3.84 11.68 21.25 18.69 15.76 * + HEMBA1000673 1.46 2.23 4.76 7.44 7.49 5.51 * + HEMBA1000675 4.18 3.09 4.54 8.18 7.19 8.04 ** + HEMBA1000678 2.23 2.7 4.47 5.03 7.16 5.16 HEMBA1000682 3.4 4.64 8.41 13.76 13.69 14.29 ** + HEMBA1000686 2.73 3.88 4.83 6.23 6.6 5.32 * + HEMBA1000702 1.56 2.07 5.25 4.15 5.78 4.32 HEMBA1000705 0.65 1.71 3.43 2.34 3.21 1.64 HEMBA1000713 3.31 5.6 6.12 6.94 5.86 5.47 HEMBA1000718 2.14 2.7 5.25 6.11 5.09 5.95 HEMBA1000719 9.64 12.27 17.77 16.64 15.52 15.64 HEMBA1000722 1.97 1.7 3.6 6.55 6.45 5.02 ** + HEMBA1000726 2.2 2.23 5.12 9.4 8.77 9.36 ** + HEMBA1000727 4.09 5.35 6.41 5.13 9.08 8.37 HEMBA1000732 1.22 2.74 4.21 4.93 5.58 4.42 HEMBA1000736 1.56 2.15 3.24 4.11 5.19 4.62 * + HEMBA1000743 1.25 2.72 3.41 5.05 4.88 4.16 * + HEMBA1000745 1.59 2.47 3.64 4.88 5.33 3.49 HEMBA1000747 1.19 1.59 2.56 2.35 3.12 1.49 HEMBA1000748 1.67 1.51 4.85 5.11 6.08 4.81 HEMBA1000749 1.14 2.04 5.69 5.98 5.91 5.96 HEMBA1000752 1.4 2.3 4.38 3.69 4.53 3.85 HEMBA1000753 2.56 4.21 6.53 7.98 8.59 4.93 HEMBA1000757 1.95 2.95 3.27 6.33 6.68 5.94 ** + HEMBA1000760 3.71 3.81 6.62 6.96 7.03 6.89 HEMBA1000769 1.99 2.36 5.17 3.48 5.87 2.85 HEMBA1000773 1 2.32 3.07 2.17 3.18 1.4 HEMBA1000774 2.69 2.76 6.37 6.29 7.77 5.22 HEMBA1000780 1.12 2.33 3.66 2.7 4.78 3.29 HEMBA1000783 1.32 2.39 4.1 2.78 7.73 2.57 HEMBA1000791 2.07 2.4 6.39 4.97 10.17 7.84 HEMBA1000793 12.73 12.73 17.88 19.93 17.49 16.69 HEMBA1000802 1.57 1.65 2.59 2.07 4.41 1.1 HEMBA1000813 38.24 35.83 34.83 54.63 42.38 53.94 * + HEMBA1000817 2.63 3.82 5.44 5.12 7.02 5.49 HEMBA1000822 1.83 2.89 4.1 4.42 5.76 3.91 HEMBA1000827 2.26 2.74 6.45 9.31 7.75 6.94 * + HEMBA1000833 3.1 4.46 7.31 8.06 4.49 4.85 HEMBA1000835 12.53 15.55 75.61 94.51 110.02 86.95 * + HEMBA1000843 1.21 2.2 4.6 3.32 5.63 4.93 HEMBA1000851 2.13 1.26 3.5 2.7 5.61 2.74 HEMBA1000852 1.95 1.83 5.5 3.52 5.49 3.83 HEMBA1000867 0.85 2.79 4.72 2.77 5.39 3.07 HEMBA1000869 0.58 1.29 2.51 2.84 3.97 2.38 HEMBA1000870 2.56 2.97 2.59 3.39 5.16 5.49 * + HEMBA1000872 1.44 2.87 4.01 4.31 4.14 4.34 HEMBA1000875 1.89 3.09 5 3.8 4.38 3.77 HEMBA1000876 1.75 3.36 4.64 3.9 6.21 4.9 HEMBA1000907 1.99 2.47 3.81 3.21 7.15 5.53 HEMBA1000908 0.81 2.06 3.85 2 5.43 1.98 HEMBA1000910 1.97 1.61 3.71 3.35 5.25 2.98 HEMBA1000918 0.76 1.34 4.37 4.93 6.54 6.95 * + HEMBA1000919 0.86 1.97 2.19 2.49 3.07 3.07 HEMBA1000934 2.5 2.56 1.16 2.14 3.51 2.5 HEMBA1000935 1.46 1.62 4.21 2.08 5.15 3.64 HEMBA1000940 1.98 3.08 3.1 2.52 9.96 5.72 HEMBA1000942 2.31 2.27 4.77 4.81 7.75 6.69 HEMBA1000943 0.58 1.25 2.28 1.83 3.38 2.18 HEMBA1000946 3.63 4.04 4.54 6.87 14.9 8.4 HEMBA1000960 2.63 3.48 9.97 10.24 12.79 10.7 HEMBA1000962 1.99 2.18 2.01 4.43 3.83 4.56 ** + HEMBA1000968 1.73 1.86 4.7 4.1 4.83 4.66 HEMBA1000971 1.75 2.51 2.9 4.18 5.27 5.71 ** + HEMBA1000972 1.45 1.57 3.83 2.63 4.44 3.49 HEMBA1000974 1.69 2.69 6.33 7.39 9.35 8.82 * + HEMBA1000975 0.9 1.83 4.17 3.31 5.54 5.12 HEMBA1000979 1.45 1.69 3.98 2.55 6.12 3.93 HEMBA1000981 4.21 6.9 9.5 11.75 13.27 14.72 * + HEMBA1000983 1.94 1.45 3.01 3.89 4.53 4.15 * + HEMBA1000985 1.58 0.92 2.75 1.73 3.28 2.79 HEMBA1000986 1.2 1.48 2.47 3.61 4.91 4.26 ** + HEMBA1000991 1.56 1.86 3.8 3.11 5.05 5.96 HEMBA1001007 0.89 1.08 4.08 1.84 3.89 2.71 HEMBA1001008 3.64 3.41 5.86 3.89 7.89 4.95 HEMBA1001009 0.89 1.3 3.07 1.58 3.83 1.81 HEMBA1001014 3.54 4.39 9.91 11.82 15.38 14.12 * + HEMBA1001017 4.21 2.82 5.6 6.04 5.41 8.55 HEMBA1001019 1.92 2.81 3.97 8.71 7.74 8.29 ** + HEMBA1001020 1.23 2.71 2.3 2.84 5.05 3.6 HEMBA1001021 1.07 1.62 2.89 3.13 5.24 2.63 HEMBA1001022 2.29 2.25 4.35 6.33 8.57 3.81 HEMBA1001024 0.31 1.14 2.16 2.87 3.97 1.26 HEMBA1001026 0.42 1.52 1.86 2 3.22 2 HEMBA1001043 1.43 2.46 2.38 4.63 5.28 4.25 ** + HEMBA1001051 3.36 2.79 11.52 13.26 18.17 18.47 * + HEMBA1001052 0.86 2.15 2.18 1.75 3.58 2.48 HEMBA1001059 5.62 9.28 26.25 40.62 56.12 43.49 * + HEMBA1001060 2.66 3.67 6.45 10.78 8.35 9.62 * + HEMBA1001064 2.12 2.87 3.3 6.04 6.48 4.69 ** + HEMBA1001071 29.39 41.54 55.57 143.9 102.43 121.71 ** + HEMBA1001077 2.37 1.77 5.21 5.36 6.66 3.96 HEMBA1001078 2.18 2.6 5.91 13.3 13.21 11.09 ** + HEMBA1001080 4.03 3.46 11.86 24.15 26.66 26.65 ** + HEMBA1001084 1.27 2.37 2.9 5.07 5.88 5.13 ** + HEMBA1001085 1.24 2.87 4.04 4.34 5.41 4.56 HEMBA1001088 6.62 6 8.04 3.79 4.34 5.81 HEMBA1001093 0.61 1.76 2.72 3.09 3.02 2.99 HEMBA1001094 0.64 0.78 2.07 2.08 2.99 1.99 HEMBA1001099 1.01 1.72 3 2.5 2.95 2.26 HEMBA1001104 1.2 1.75 2.63 3.64 8.04 3.3 HEMBA1001109 4.87 3.77 8.57 11.32 14.48 11.73 * + HEMBA1001114 44.68 41.2 93.35 141.87 145.19 167.76 ** + HEMBA1001121 2.14 2.03 3.87 2.41 6 3.25 HEMBA1001122 9.79 10 14.12 7.73 11.5 22.69 HEMBA1001123 2.79 3.28 5.2 5.81 6.02 4.95 HEMBA1001133 0.97 1.69 2.54 2.78 3.84 1.21 HEMBA1001137 0.82 1.73 3.65 3.74 3.36 2.54 HEMBA1001140 1.23 2.75 2.98 3.62 5.18 4.34 * + HEMBA1001144 4.12 3.41 9.06 14.13 14.12 13.96 ** + HEMBA1001145 47.87 43.87 65.7 98.4 75.15 81.3 * + HEMBA1001158 7.55 9.5 11.62 13.02 7.58 12.5 HEMBA1001172 1.44 2.85 4.37 5.32 5.77 5.17 * + HEMBA1001174 0.95 2.06 2.83 3.88 6.31 3.25 HEMBA1001175 6.93 8.56 10.73 14.17 14.5 10.18 HEMBA1001182 16.93 19.89 82.44 135.93 145.36 122.22 * + HEMBA1001184 1.41 1.24 2.45 1.85 3.03 1.47 HEMBA1001192 1.72 1.75 4.01 5.65 5.17 3.98 HEMBA1001196 2.31 3.63 7.61 9.43 10.51 8.97 * + HEMBA1001197 31.18 35.89 86.14 95.35 83.09 93.59 HEMBA1001208 1.83 2.59 3 2.67 5.3 2.61 HEMBA1001213 12.99 16.12 69.9 102.88 119.96 113.72 * + HEMBA1001214 1.39 3.11 4.36 5.14 7.04 4.62 HEMBA1001221 1.63 1.62 3.66 2.06 4.19 1.89 HEMBA1001225 1.06 2.66 3.53 1.44 3.43 1.52 HEMBA1001226 4.76 4.65 11.94 13.58 15.58 14.92 * + HEMBA1001228 72.4 75.3 102.4 38.23 64.63 78.89 HEMBA1001229 18 21.39 82.05 115.91 145.39 128.91 * + HEMBA1001235 3.58 4.11 6.48 7.31 6.7 10.2 HEMBA1001238 2.46 2.49 7.23 4.6 6.94 4.74 HEMBA1001242 15.36 14.03 91.45 92.81 94.02 90.34 HEMBA1001247 4.41 4.36 12.46 12.48 14.07 15.62 HEMBA1001253 8.79 11.4 61.56 77.17 102.24 94.81 * + HEMBA1001257 1.98 2.71 3.78 3.52 4.29 3.17 HEMBA1001261 3.01 3.18 4.56 4.54 3.75 5.59 HEMBA1001262 1.48 3.79 2.81 2.42 4.34 4.59 HEMBA1001265 2.76 3.21 6.85 5.5 7.32 5.1 HEMBA1001266 3.97 3.17 6.31 7.8 10.5 8.38 * + HEMBA1001269 15.98 10.36 12.79 22.69 24.71 25.21 ** + HEMBA1001272 1.31 2.04 4.3 1.62 5.12 2.07 HEMBA1001279 2.54 3.52 13.6 18.68 23.45 18.99 * + HEMBA1001281 16.58 20.99 40.84 47.71 59.04 45.72 * + HEMBA1001286 3.25 4.71 10.71 11.24 10.65 12.38 HEMBA1001289 0.41 1.57 1.64 1.3 3.57 2.41 HEMBA1001291 3.52 4.58 9.53 10.91 18.3 18.8 * + HEMBA1001294 2.01 1.81 4.6 4.04 7.73 5.12 HEMBA1001296 3.4 3.52 4.37 3.77 5.94 5.22 HEMBA1001297 2.88 3.61 5.51 4.81 6.88 5.38 HEMBA1001299 2.49 2.9 6.21 6.45 8.84 7.74 * + HEMBA1001302 9.42 11.94 15.5 23.25 35.12 25.74 * + HEMBA1001303 1.8 1.99 2.61 3.57 3.8 3.3 ** + HEMBA1001306 1.4 1.15 2.85 5.01 4.46 4.82 ** + HEMBA1001308 3.43 4.37 16.7 16.31 18.28 21.75 HEMBA1001310 1.93 1.71 4.17 2.38 6.26 3.28 HEMBA1001312 10.09 10.35 17.42 20.51 24.71 21.67 * + HEMBA1001319 1.23 1.41 3.85 2.23 4.27 4.01 HEMBA1001322 1.81 2.29 4.17 2.83 4.74 3.78 HEMBA1001323 4.04 3.65 8.44 14.68 23.44 18.68 * + HEMBA1001326 8.79 7.35 10.15 12.24 13.62 15.04 * + HEMBA1001327 0.94 1.65 3.18 3.55 5.18 4.56 * + HEMBA1001330 1.59 2.22 6.96 7.36 9.28 9.64 * + HEMBA1001348 1.68 3.99 3.89 6.33 9.84 7.47 * + HEMBA1001350 5.28 4.16 6.34 7.24 13.17 10.12 HEMBA1001351 15.37 14.99 17.64 37.37 49.52 25.96 * + HEMBA1001352 3.25 3.62 5.97 8.16 13.65 5.75 HEMBA1001353 30.24 37.73 49.4 76.74 96.09 96.34 ** + HEMBA1001358 13.98 9.73 17.96 30.89 27.69 30.6 ** + HEMBA1001361 1.7 3.24 4.96 4.18 6.08 6.06 HEMBA1001364 0.8 1.71 2.4 1.47 4.11 2.95 HEMBA1001375 3.45 2.77 5.75 5.71 5.83 6.32 HEMBA1001377 2.81 3.16 7.36 5.37 7.98 7.89 HEMBA1001383 0.25 1.64 2.61 1.26 2.47 1.84 HEMBA1001387 1.81 2.15 3.66 1.94 5.14 2.47 HEMBA1001388 1.52 1.78 5.07 2.01 4.61 3.49 HEMBA1001390 34.61 34.52 66.57 67.03 50 56.4 HEMBA1001391 1.65 2.77 4.83 4.32 7.98 3.82 HEMBA1001398 1.98 2.87 7.47 7.24 10.42 8.29 HEMBA1001405 1.17 2 3.87 2.99 5.3 2.61 HEMBA1001406 2.01 3.27 3.75 5.35 6.62 4.33 * + HEMBA1001407 1.13 1.78 3.73 6.39 6.64 4.44 * + HEMBA1001411 1.44 2.81 4.47 7.2 6.35 6.04 * + HEMBA1001413 1.84 1.53 3.31 3.61 3.75 3.76 HEMBA1001414 1.47 2.34 5.3 5.33 7.22 5.47 HEMBA1001415 1.91 2.36 4.97 4.4 5.86 4.29 HEMBA1001416 4.73 4.85 9.54 8.87 11.06 9.4 HEMBA1001432 1.23 1.27 4.43 4.27 6.64 3.59 HEMBA1001433 1.96 2.93 4.55 4.33 8.66 3.64 HEMBA1001435 2.17 2.27 6.39 7.02 10.35 5.88 HEMBA1001442 0.99 0.68 2.02 2.36 3.12 1.81 HEMBA1001446 1.87 1.84 5.82 9.71 8.93 11.01 ** + HEMBA1001450 2.35 2.32 11.22 8.61 10.08 6.34 HEMBA1001454 3.08 4.25 9.69 13.64 10.73 11.82 * + HEMBA1001455 2.28 2.7 3.11 2.69 5.54 2.8 HEMBA1001459 2.74 3.37 6.03 5.07 7.38 5.52 HEMBA1001461 3.34 4.47 6.96 6.8 9.85 7.47 HEMBA1001462 1.07 1.47 2.79 2.67 4.5 2.54 HEMBA1001463 1.38 1.61 5.25 4.95 5.46 5.51 HEMBA1001469 3.9 4.51 7.32 10.63 9.83 7.76 * + HEMBA1001473 4.56 3.49 8.25 7.52 10.34 6.53 HEMBA1001477 2.14 1.59 4.64 3.41 5.75 2.59 HEMBA1001478 2.46 2.8 3.77 2.95 3.73 2.55 HEMBA1001480 4.15 6.8 8.96 11.64 11.87 8.48 HEMBA1001483 1.9 1.64 5.71 6.6 8.22 7.23 * + HEMBA1001490 1.45 2.09 3.76 5.16 4.52 4.65 * + HEMBA1001495 56.8 53.41 123.27 193.11 133.65 132.04 HEMBA1001497 2.06 1.98 7.47 4.81 8.45 5.85 HEMBA1001510 3.99 4.23 15.22 11.46 13.7 14.56 HEMBA1001515 1.45 2.33 4.02 3.73 6.11 3.04 HEMBA1001517 1.6 2.21 4.6 5.26 5.4 4.6 HEMBA1001522 1.56 2.72 3.77 3.61 6.37 2.43 HEMBA1001526 2.19 2.97 4.97 4.05 4.38 3.59 HEMBA1001533 3.19 2.86 6.23 6.83 7.76 4.64 HEMBA1001547 7.26 5.37 13.69 5 7.96 6.19 HEMBA1001552 7.12 4.72 17.79 16.12 16.3 16.05 HEMBA1001553 41.67 45.48 66.23 57.2 47.01 79.81 HEMBA1001557 2.24 2.93 5.15 5.81 8.33 4.59 HEMBA1001563 1.69 2.4 4.56 3.66 6.99 4.76 HEMBA1001566 1.42 3.27 8.29 5.94 9.04 5.84 HEMBA1001569 11.15 11.91 26.6 30.2 31.14 32.61 * + HEMBA1001570 3.25 4.61 10.2 9.19 10.25 9.53 HEMBA1001579 3.63 4.4 7.77 9.26 7.4 9.93 HEMBA1001581 2.79 3.33 10.95 8.81 12.09 9.08 HEMBA1001582 3.22 3.18 6.68 6.35 6.84 4.03 HEMBA1001585 2.7 3.07 4.52 4.4 5.6 3.5 HEMBA1001589 1.82 2.31 3.63 4.39 6.19 3.78 HEMBA1001595 13.06 15.57 19.7 13.25 13.29 14.02 HEMBA1001604 1.96 2.67 3.64 3.76 6.53 2.82 HEMBA1001608 5.58 7.09 16.17 14.14 16.46 14.43 HEMBA1001615 113.28 90.33 205.41 240.97 118.65 165.59 HEMBA1001620 3.71 5.56 10.54 12.22 12.24 11.46 HEMBA1001621 0.76 2.13 3.42 1.76 3.44 2.97 HEMBA1001635 2.32 2.13 3.41 3.55 4.9 2.85 HEMBA1001636 1.9 1.93 4.01 3.34 5.33 2.97 HEMBA1001640 3.07 3.31 13.65 10.96 15.01 10.74 HEMBA1001647 8.92 8.44 57.38 88.92 112.42 87.46 * + HEMBA1001651 2.53 3.54 7.85 6.62 9.07 8.73 HEMBA1001655 2.09 2.66 4.78 3.35 6.75 4.09 HEMBA1001658 4.33 4.5 9.27 7.26 11.15 8.6 HEMBA1001661 0.75 1.78 2.8 1.98 3.22 1.77 HEMBA1001665 1.52 1.85 3.47 2.63 6.63 1.73 HEMBA1001670 5.32 6.54 8.82 12.45 15.21 12.42 ** + HEMBA1001672 2.49 3.06 5.9 4.28 7.62 3.39 HEMBA1001673 8.23 10.76 13.22 20.04 19.39 15.65 * + HEMBA1001675 2.4 2.01 2.53 3.21 5.79 3.36 HEMBA1001676 54.19 46.09 107.65 245.72 212.81 275.65 ** + HEMBA1001678 9.46 10.2 21.87 23.65 19.51 27.88 HEMBA1001680 4.58 4.89 12.32 9.39 10.95 11.65 HEMBA1001681 1.71 2.44 5.75 6.25 9.11 6.36 HEMBA1001684 1.89 2.74 6.26 4.32 7.57 6.98 HEMBA1001695 1.48 2.08 3.42 2.3 4.76 3.15 HEMBA1001702 1.54 2.96 3.55 2.36 7.57 3.09 HEMBA1001709 1.23 1.8 3.51 3.21 4.87 3.5 HEMBA1001711 1.29 1.98 2.83 2.99 2.45 3.18 HEMBA1001712 0.92 1.55 2.56 2.13 3.02 2.24 HEMBA1001714 10.37 10.82 19.06 23.54 22 23.8 * + HEMBA1001717 79.4 71.16 124.25 152.62 195.81 173.65 * + HEMBA1001718 1.95 2.12 7.32 5.99 6.59 5.26 HEMBA1001723 3.43 3 10.19 9.09 12.53 9.64 HEMBA1001731 1.3 1.36 3.27 1.58 4.8 2.29 HEMBA1001734 2.37 2.38 4.28 4.78 6.06 4.27 HEMBA1001736 2.3 2.12 2.87 3.5 4.69 5.33 * + HEMBA1001741 1.69 2.19 3.5 4.02 4.74 2.9 HEMBA1001744 0.86 0.94 2.81 2 3.64 2.64 HEMBA1001745 0.95 1.56 2.3 2.53 5.28 2.58 HEMBA1001746 4.02 3.91 8.66 9.21 12.06 7.01 HEMBA1001761 2.2 2.01 4.69 2.58 3.95 3.37 HEMBA1001762 1.41 1.6 3.57 1.93 4.38 2.03 HEMBA1001781 1.56 1.5 4.17 2.15 5.87 3.25 HEMBA1001784 1.36 1.39 4.5 4.02 3.58 3.75 HEMBA1001791 2.16 1.74 6.97 6.04 7.62 5.68 HEMBA1001794 2.15 4.31 12.57 13.54 13.65 12.96 HEMBA1001800 5.61 9.63 60.44 84.85 100.03 76.26 * + HEMBA1001803 2.84 4.25 5.36 4.27 7.02 3.67 HEMBA1001804 6.2 8.13 20.95 29.84 26.86 24.39 * + HEMBA1001808 1.61 1.6 3.87 3.71 3.67 2.89 HEMBA1001809 8.07 6.27 10.64 14.33 20.56 16.63 * + HEMBA1001811 8.32 7.83 16.8 22.75 21.75 17.6 * + HEMBA1001815 1.75 2.67 6.56 5.58 6.33 5.03 HEMBA1001816 1.96 2.67 4.47 3.09 4.6 3.04 HEMBA1001819 0.98 3.09 6.16 6.19 8.53 6.3 HEMBA1001820 0.93 1.32 2.22 2.36 3.32 1.21 HEMBA1001822 1.87 2.06 5.43 6.02 7.7 4.44 HEMBA1001824 3.21 4.62 14.88 12.81 16.29 12.34 HEMBA1001835 1.04 1.05 3.05 3.72 5.21 3.14 HEMBA1001844 7.88 6.55 18.04 17.77 21.36 13.19 HEMBA1001847 0.93 1.8 5.21 1.96 5.18 3.06 HEMBA1001849 2.32 2.77 7.58 6.65 8.19 7.62 HEMBA1001850 2.51 2.71 8.43 8.76 8.88 7.89 HEMBA1001861 0.95 2.04 1.73 2.64 3.93 2.01 HEMBA1001862 138.58 133.42 191.61 266.65 221.43 227.58 * + HEMBA1001864 1.31 1.16 2.44 4.79 2.88 2.59 HEMBA1001866 1.49 2.39 7.45 7.67 7.07 4.61 HEMBA1001869 7.55 6.84 10.82 10.31 7.69 9.02 HEMBA1001871 29.48 30.98 54.77 63.07 62.43 66.59 * + HEMBA1001876 0.96 1.27 4.42 2.08 4.57 2.26 HEMBA1001878 2.23 3.34 5.7 6.83 8.18 5.5 HEMBA1001879 1.89 2.57 5.58 5.99 7.24 5.72 HEMBA1001884 6.21 6.49 17.14 11.31 12.71 10.87 HEMBA1001886 2.12 2.21 4.38 4.57 5.67 4.23 HEMBA1001888 2 2.12 6.6 7.41 10.17 9.46 * + HEMBA1001890 4.03 3.67 7.6 6.8 7.01 4.4 HEMBA1001896 1.34 1.61 2.62 2.27 4.12 3.01 HEMBA1001899 33.43 39.48 61.77 106.52 41.01 101.91 HEMBA1001904 76.64 122.45 233.99 299.33 174.47 322.82 HEMBA1001910 1.4 1.93 3.23 2.53 6.35 2.97 HEMBA1001911 8.36 8.75 10.86 21.15 16.9 13.23 * + HEMBA1001912 8.92 7.97 33.97 57 51.9 48.59 * + HEMBA1001913 4.89 6.19 17.29 18.56 14.16 16.85 HEMBA1001915 1.35 2.61 4.49 3.3 5.63 2.46 HEMBA1001918 15.23 13.29 21.07 17.07 14.31 12.13 HEMBA1001921 4 3.5 4.38 5.2 5.35 4.86 * + HEMBA1001931 1.19 1.95 2.53 2.14 5.17 2.19 HEMBA1001939 1.92 1.77 4.72 1.97 5.21 2.57 HEMBA1001940 2.61 2.99 7.14 3.51 5.86 3.24 HEMBA1001942 1.18 1.88 3.71 2.33 5.14 1.56 HEMBA1001944 4.35 5.83 42.16 51.42 66.43 59.75 * + HEMBA1001945 0.98 2.3 2.95 2.98 3.4 2.21 HEMBA1001950 2.56 2.84 7.87 5.72 5.23 3.68 HEMBA1001951 10.37 11.26 15.33 24.16 18.26 22.94 * + HEMBA1001958 1.04 1.28 2.58 3.1 4.83 2.54 HEMBA1001960 6.87 6.28 13.93 10.02 12.99 12.47 HEMBA1001962 1.01 1.08 4.19 1.58 4.24 1.67 HEMBA1001964 1.39 3.45 4.13 2.54 4.45 3.39 HEMBA1001967 6.06 5.65 9.33 14.45 10.5 13.18 * + HEMBA1001979 0.7 2.67 3.31 2.04 3.46 2.4 HEMBA1001987 1.96 3.92 7.99 6.19 8.35 7.22 HEMBA1001991 1.61 3.59 9.06 5.06 8.7 7.44 HEMBA1002003 4.86 4.71 14.56 15.86 16.03 22.9 HEMBA1002005 2.62 3.39 7.82 4.16 7.48 4.76 HEMBA1002008 2.64 3.51 7.78 6.07 10.15 6.37 HEMBA1002018 1.86 2.37 4.23 3.32 5.47 3.87 HEMBA1002022 0.52 2.3 2.5 2.83 3.53 2.82 HEMBA1002029 43.82 40.22 73.75 89.27 96.12 122.81 * + HEMBA1002030 2.23 2.88 4.32 3.88 4.26 4.67 HEMBA1002035 1.69 1.75 3.82 5.43 5.14 3.75 HEMBA1002037 4.47 4.34 6.69 4.5 6.47 7.94 HEMBA1002038 4.12 3.13 7.74 6.36 8.8 5.42 HEMBA1002039 2.46 3.43 7.03 6.74 8.99 6.37 HEMBA1002042 5.52 5.55 9.8 10.55 13.01 9.94 HEMBA1002043 3.81 3.79 11.32 12.53 12.64 13.95 HEMBA1002048 2.76 2.31 3.81 2.03 4.32 3.44 HEMBA1002049 1.72 2.35 5.55 4.43 5.2 5.2 HEMBA1002053 7.33 6.91 14.52 11.09 15.25 13.63 HEMBA1002055 9.81 8.76 10.65 18.44 13.58 17.78 * + HEMBA1002056 2.24 2.62 4.26 5.46 8.06 5.67 * + HEMBA1002061 2.24 2.51 4.58 4.17 5.34 4.58 HEMBA1002080 46.55 49.5 54.6 91.78 122.41 83.23 * + HEMBA1002084 0.71 1.43 2.36 3.25 3.66 2.64 * + HEMBA1002085 0.97 1.47 2.87 3.45 4.52 3.74 * + HEMBA1002092 1.79 1.56 3.94 4.01 5.53 4.15 HEMBA1002098 1.51 1.82 4.12 3.2 5.11 2.83 HEMBA1002100 9.07 8.18 22.37 25.95 23.04 29.67 HEMBA1002101 18.26 17.64 27.49 23.44 27.16 23.74 HEMBA1002102 2.65 1.98 5.99 4.58 7.06 6.99 HEMBA1002105 6.79 6.2 22.13 24.47 40.8 25.31 HEMBA1002107 57.97 37.86 84.35 155.21 136.27 136.87 ** + HEMBA1002113 6.77 4.75 17.24 12.05 12.83 14.78 HEMBA1002119 3.85 3.28 24.05 24.29 30.66 27.04 HEMBA1002125 7.03 6.73 10.43 11.38 7.34 11.85 HEMBA1002131 9.71 9.72 20.58 14.97 19.12 13.71 HEMBA1002133 3.67 3.52 6.32 6.97 9.51 9.46 * + HEMBA1002139 0.75 1.07 3.35 1.52 4.37 1.47 HEMBA1002141 1.67 1.36 3.23 2.99 3.92 2.14 HEMBA1002144 2.33 2.44 6.11 5.28 5.68 6.57 HEMBA1002147 8.84 9.55 17.93 36.22 21.92 21.88 HEMBA1002150 38.34 38.68 51.42 19.74 26.62 15.85 * - HEMBA1002151 3.76 3.36 9.95 11.15 14.23 9.84 HEMBA1002153 0.57 1.74 3.36 3.39 5.64 2.96 HEMBA1002156 0.8 1.74 2.33 1.94 4.28 1.26 HEMBA1002160 2.16 3.17 5.7 6.08 7.26 6.18 HEMBA1002161 2.13 2.9 6.99 13.53 11.79 9.76 * + HEMBA1002162 2.65 2.17 7.76 5.61 6.27 7.81 HEMBA1002163 12.02 12.04 19.93 34.48 19.96 27.11 HEMBA1002164 6.58 10.55 59.92 71.46 78.61 67.82 HEMBA1002166 21.88 18.32 39.58 57.35 49.05 46.09 * + HEMBA1002167 0.89 2.89 3.89 4.96 5.45 3.98 HEMBA1002173 3.24 3.83 6.22 7.97 7.11 6.28 HEMBA1002177 1.31 1.78 3.31 5.68 4.97 2.98 HEMBA1002178 6.91 10.17 14.77 23.33 23.58 17.49 * + HEMBA1002179 53.56 46.86 94.4 58.33 85.22 54.47 HEMBA1002185 2.75 4.07 13.4 11.73 16.23 14.56 HEMBA1002188 5.76 7.57 10.27 11.86 12.9 9.8 HEMBA1002189 1.98 2.85 4.96 5.23 4.63 4.71 HEMBA1002191 0.67 2.16 4.96 3.47 5.44 2.81 HEMBA1002192 2.98 2.83 4.91 7.53 8.35 4.57 HEMBA1002195 2.96 3.27 6.6 10.35 10.11 7.27 * + HEMBA1002196 3.34 4.33 8.55 8.62 8.85 8.39 HEMBA1002199 1.33 1.86 4.9 4.62 5.71 3.52 HEMBA1002204 1.31 1.97 4.08 5.48 11.37 3.73 HEMBA1002208 24.58 26.61 45.85 49.77 25.48 39.6 HEMBA1002212 3.73 5.95 9.01 8.9 11.85 17.18 HEMBA1002215 1.95 2.63 4.27 5.1 3.54 3.78 HEMBA1002217 15.61 16.71 59.91 78.46 82.88 80.94 * + HEMBA1002220 1.11 2.07 4.1 3.58 3.39 2.33 HEMBA1002226 2.17 3.13 9.18 10.47 12.61 9.58 HEMBA1002227 39.9 47.13 92.5 109.42 65.74 71.79 HEMBA1002229 4.5 4.77 13.39 11.16 13.55 12.49 HEMBA1002237 1.73 3.22 4.08 3.71 5.64 3.41 HEMBA1002239 9.36 13.83 72.18 100.62 109.3 113.84 * + HEMBA1002241 7 7.54 38.36 64.27 68.93 68.72 ** + HEMBA1002253 1.11 2.44 3.33 2.3 4.42 2.68 HEMBA1002257 1.83 2.65 4.11 3.18 3.6 1.74 HEMBA1002259 1.12 2.17 2.69 3.12 3.6 2.67 HEMBA1002262 6.95 7.37 19.16 14.43 14.78 17.04 HEMBA1002265 1.35 1.63 3.7 3.75 6.23 2.43 HEMBA1002267 16.87 20.81 22.76 32.99 16.96 27.5 HEMBA1002270 3.73 4.79 7.49 8.18 13.43 8.7 HEMBA1002286 1.03 1.86 5.42 2.85 5.53 0.98 HEMBA1002290 4.73 3.7 7.52 5.16 8.88 4.38 HEMBA1002302 6.12 9.63 45.04 45.66 49.69 45.23 HEMBA1002304 3.28 3.42 6.88 5.57 6.97 4.34 HEMBA1002307 45.71 53.69 92.31 71.87 55.79 61.03 HEMBA1002316 2.16 3.29 4.63 3.04 5.32 2.41 HEMBA1002319 1.97 2.96 4.46 8.32 9.58 8 ** + HEMBA1002320 1.99 1.76 3.22 2.51 4.45 1.76 HEMBA1002321 1.22 2.04 2.84 2.71 4.44 2.77 HEMBA1002328 2.44 3.04 4.89 2.43 5.73 2.94 HEMBA1002333 3.88 4.27 7.14 7.37 10.84 7.5 HEMBA1002337 3.02 3.62 5.5 5.98 7.49 7.48 * + HEMBA1002339 15.86 13.92 111.66 135.44 169.95 156.76 * + HEMBA1002341 0.8 2.08 3.22 2.71 4.34 2.35 HEMBA1002348 2.84 2.78 7.14 3.69 6.73 4.49 HEMBA1002349 1.28 1.44 3.59 2.24 4.64 2.59 HEMBA1002353 1.83 3.04 4.03 4.61 7.72 5.68 HEMBA1002356 6.05 6.96 17.53 14.27 16.02 16.1 HEMBA1002357 114.85 156.08 306.32 300.67 286.5 328.19 HEMBA1002360 7.18 8.32 8.29 14.57 14.46 13.78 ** + HEMBA1002363 2.79 3.35 4.84 7.02 8.02 8.72 ** + HEMBA1002365 1.7 2.7 2.7 1.63 3.12 2.67 HEMBA1002370 1.43 1.78 2.37 1.53 4.2 1.9 HEMBA1002374 4.55 4.53 7.79 8.33 10.27 9.11 * + HEMBA1002376 46.59 33.18 118.8 101.1 189.18 114.36 HEMBA1002377 18.02 20.98 25.61 32.58 34.44 32.19 ** + HEMBA1002380 5.68 6.36 16.28 17.43 21.85 18.83 HEMBA1002381 1.52 1.8 4.16 4.12 7.16 4.94 HEMBA1002384 1.79 3.09 3.69 5.67 4.27 5.71 * + HEMBA1002389 1.93 2.93 2.88 3.63 5.31 4.7 * + HEMBA1002396 21.16 20.01 36.93 14.29 14.94 19.1 HEMBA1002402 125.09 124.52 168.42 100.85 107.79 164.62 HEMBA1002417 1.41 1.07 4.27 2.17 3.19 2.6 HEMBA1002419 1.42 2.38 3.8 1.81 4.59 2.41 HEMBA1002420 9.55 11.97 14.11 16.34 18.28 16.16 * + HEMBA1002421 7.47 10.35 12.5 8.97 10.24 9.6 HEMBA1002423 2.89 1.3 4.28 3.35 4.29 3.82 HEMBA1002424 11.91 10.05 25.13 9.11 9.2 10.43 HEMBA1002426 3.42 3.69 5.56 7.57 8.24 5.6 * + HEMBA1002430 0.39 1.41 2.51 1.7 4.19 2.85 HEMBA1002439 1.59 1.94 4.17 2.69 4.46 6.8 HEMBA1002441 31.85 29.77 27.79 48.74 52.7 34.64 HEMBA1002454 0.62 1.48 2.27 1.76 2.43 1.55 HEMBA1002458 3.17 5 8.09 10.24 10.55 11.71 * + HEMBA1002460 2.14 1.59 3.89 5.16 4.63 5.01 * + HEMBA1002462 5.18 3.83 9.52 11.92 9.29 8.58 HEMBA1002465 0.93 1.96 2.26 1.46 3.13 1.27 HEMBA1002469 6.88 7.27 45.87 49.02 75.59 67.74 * + HEMBA1002475 1.54 2.35 8.01 4.88 7.87 7.66 HEMBA1002477 1.75 1.59 5.25 3.19 6.99 3.55 HEMBA1002480 4.46 3.98 8.49 8.76 13 10.54 HEMBA1002481 1.9 2.02 4.22 2.71 6.25 4.7 HEMBA1002486 3.62 3.98 10.08 9.98 8.04 9.75 HEMBA1002490 2.02 3.08 5.7 8.76 9.64 7.65 * + HEMBA1002495 2.37 2.29 3.78 3.92 4.79 4.08 HEMBA1002498 0.95 2.14 2.97 1.83 5.09 2.14 HEMBA1002501 2.96 4.73 14.13 19.98 23.55 17.54 * + HEMBA1002503 1.7 2.52 5.11 4.68 7.06 2.97 HEMBA1002504 1.95 2.19 5.99 6.68 7.09 4.65 HEMBA1002508 1.48 2.59 5.99 7.8 7.47 5.65 HEMBA1002513 1.31 1.7 4.85 3.91 7.67 3.02 HEMBA1002515 1.17 1.82 3.04 2.67 5.1 2.89 HEMBA1002524 1.67 2.09 2.53 4.44 4.49 3.82 ** + HEMBA1002538 4.68 4.14 7.39 9.31 8.91 7.86 * + HEMBA1002542 3.31 3.27 6.77 10.11 9.3 7.74 * + HEMBA1002544 1.42 2.24 3.33 2.69 6.59 3.24 HEMBA1002546 31.01 31.64 56.69 95.52 83.15 72.77 * + HEMBA1002547 3.13 3.22 8.44 20.11 20.37 17.21 ** + HEMBA1002550 5.46 3.86 10.87 10.85 11.2 10.23 HEMBA1002551 2.15 3.09 5.8 3.7 5.08 3.08 HEMBA1002552 2.21 2.06 8.39 5.66 6.55 5.68 HEMBA1002555 1.54 1.78 4.56 2.27 4.4 2.97 HEMBA1002558 2.74 3.26 7.02 8.08 7.47 8.27 HEMBA1002561 1.01 1.58 5.26 4.42 5.08 3.87 HEMBA1002562 0.59 0.83 2.34 3.29 3.29 2.36 HEMBA1002568 1.71 1.16 3.09 3.06 3.26 3.6 HEMBA1002569 3.8 4.67 10.32 7.29 8.59 5.14 HEMBA1002570 5.22 4.72 9.84 6.07 10.29 12.99 HEMBA1002574 24.62 22.75 26.01 44.47 30.74 40.85 * + HEMBA1002583 4.07 4.52 8.07 6.64 6.43 8.47 HEMBA1002587 9.78 10.9 19.23 24.67 18.08 20.4 HEMBA1002590 2.51 2.58 7.47 5.35 5.6 4.05 HEMBA1002592 2.51 3.03 6.4 6.34 7.84 5.1 HEMBA1002595 1.66 2.13 3.1 4.12 4.25 2.68 HEMBA1002609 4.47 6.27 51 68.51 85.44 66.33 * + HEMBA1002617 6.31 4.76 7.99 7.25 6.84 6.48 HEMBA1002619 3.33 4.8 5.99 7.86 6.14 7.27 HEMBA1002621 1.21 2.94 3.09 3.24 4.17 2.03 HEMBA1002624 4.6 5.19 19.48 22.04 24.39 26.87 * + HEMBA1002628 3.37 3.64 6.41 6.08 6.11 4.1 HEMBA1002629 2.71 2.24 4.66 3.77 7.98 4.48 HEMBA1002632 1.39 2.23 5.16 4.29 5.49 4.58 HEMBA1002645 1.77 1.98 6.43 4.68 6.91 5.37 HEMBA1002651 1.87 2.73 4.73 4.68 4.83 3.74 HEMBA1002652 3.38 5.27 6.21 6.09 8.66 7.92 HEMBA1002659 2.84 3.86 4.8 6.32 8.18 9.6 * + HEMBA1002661 3 2.71 6.19 4.41 6.93 4.93 HEMBA1002666 1.74 2.47 4.21 2.95 4.25 1.41 HEMBA1002667 1.39 2.25 3.91 2.79 5.24 1.94 HEMBA1002673 16.08 19.36 30.31 32.54 35.18 29.96 HEMBA1002678 2.11 2.33 7.44 5.39 5.98 4.22 HEMBA1002679 1.23 2.33 5.25 3.7 7.48 3.81 HEMBA1002688 1.74 2.98 8.3 8.33 11.41 7.86 HEMBA1002696 1.7 2.79 2.92 3.48 6.13 3.32 HEMBA1002703 2.95 3.88 10.15 8.35 9.73 9.21 HEMBA1002706 4.97 4.24 8.99 5.07 7.16 5.54 HEMBA1002712 2.39 3.94 8.67 8.4 10.9 10.57 HEMBA1002715 7.92 9.81 49.65 79.65 93.63 79.61 * + HEMBA1002716 3.93 4.26 5.53 4.63 5.02 4.53 HEMBA1002718 11.79 12.87 17.77 24.16 18.07 24.3 * + HEMBA1002728 2.37 3.1 5.01 5.52 5.94 4.42 HEMBA1002730 1.13 2.48 5.86 3.71 6.19 4.61 HEMBA1002734 2.89 3.54 8.82 8.6 10.7 10.59 HEMBA1002742 1.94 2.06 3.96 1.86 4.27 2.74 HEMBA1002746 1.2 2.86 4.61 2.83 4.43 2.94 HEMBA1002748 2.19 1.75 4.01 5.36 5.98 3.92 HEMBA1002750 1.99 2.46 3.45 6.74 6.39 6.27 ** + HEMBA1002755 1.85 3.1 5.31 5.96 6.62 5.16 HEMBA1002759 1.93 3.12 7.98 4.65 7.92 7.08 HEMBA1002763 9.62 12.05 74.52 68.84 88.82 77.22 HEMBA1002767 4.48 5.85 5.8 8.88 6 6.13 HEMBA1002768 2.99 3.76 6.2 3.46 8.3 3.04 HEMBA1002769 1.47 2.35 2.82 3.46 5.21 3.49 HEMBA1002770 5.89 5.83 12.41 14.24 22.53 15.53 * + HEMBA1002777 1.6 1.9 2.58 2.29 4.74 3.76 HEMBA1002779 10.92 7.6 16 17.39 19.81 19.36 * + HEMBA1002780 2.6 2.77 6.82 6.43 6.89 6.35 HEMBA1002790 3.14 2.52 10.6 7.26 8.67 9.25 HEMBA1002794 1.52 2.28 5.49 3.68 6.8 4.45 HEMBA1002798 1.33 1.59 3.61 2.77 5.12 4 HEMBA1002801 2.13 2.25 3.64 3.12 6.93 5.24 HEMBA1002810 4.56 3.99 7.85 10.27 17.31 11.1 * + HEMBA1002816 2.24 1.97 2.88 5.34 5.05 4.8 ** + HEMBA1002818 24.6 23.26 95.11 130.84 121.74 135.78 * + HEMBA1002820 1.95 2.63 6.41 6.96 6.99 6.04 HEMBA1002826 1.96 1.48 2.99 3.21 4.84 3.59 HEMBA1002833 8.71 7.46 19.84 20.18 21.16 20.04 HEMBA1002850 1.16 1.94 3.67 3.87 4.96 5.11 * + HEMBA1002862 9.06 9.31 17.9 20.11 25.3 13.43 HEMBA1002863 2.47 2.93 5.28 6.16 8.44 6.52 * + HEMBA1002867 1.51 1.17 2.4 2.3 3.28 1.87 HEMBA1002876 3.9 3.54 5.48 5.61 5.78 6.48 HEMBA1002886 1.28 1.56 2.45 1.83 3.13 2.71 HEMBA1002896 5.82 3.82 9.38 7.22 11.23 8.51 HEMBA1002913 2.37 2.22 4.56 4.19 4.28 3.11 HEMBA1002921 0.97 0.81 2.36 1.82 2.41 1.41 HEMBA1002924 1.07 1.2 2.86 2.11 4.41 3.27 HEMBA1002934 6.01 5.17 10.48 9.93 15.27 13.16 HEMBA1002935 4.27 2.55 6.59 7.1 5.34 7.14 HEMBA1002937 4.61 5.71 9.4 10.82 8.36 7.36 HEMBA1002939 2.21 2.92 5.39 5.51 5.7 3.26 HEMBA1002944 1.45 1.97 4.66 3.1 5.68 3.21 HEMBA1002951 5.88 7.88 10.99 6.04 12.17 5.67 HEMBA1002954 2.4 4.57 6.12 6.09 7.78 4.78 HEMBA1002962 3.93 6.02 9.14 13.42 15.92 12.44 * + HEMBA1002968 1.22 1.71 4.32 5.34 4.07 5.3 HEMBA1002970 1.13 1.13 3.14 2.5 3.72 3.13 HEMBA1002971 0.96 2.02 2.75 2.02 3.71 2.43 HEMBA1002973 1.68 3.36 7.84 6.19 10.81 6.31 HEMBA1002978 2.09 3.81 4.35 5.49 5.3 4.22 HEMBA1002981 1.82 2.51 4.01 9.33 7.48 6.53 ** + HEMBA1002985 0.83 1.92 4.91 4.74 5.59 4.13 HEMBA1002986 2.72 4.88 6.67 14.7 14.62 13 ** + HEMBA1002988 1.77 2.36 4.25 4.2 5.67 3.46 HEMBA1002992 8.73 11.38 68.65 83.81 96.4 94.02 * + HEMBA1002995 6.13 6.97 11.94 8.64 11.47 14.09 HEMBA1002997 5.77 6.33 9.6 12.88 10.65 8.75 HEMBA1002999 1.36 2.77 2.84 2.48 3.92 3.31 HEMBA1003004 0.78 1.39 1.96 1.86 3.32 1.37 HEMBA1003006 2.03 1.84 4.26 5.44 8.08 5.87 * + HEMBA1003008 1.58 1.26 2.83 3.4 5.4 2.28 HEMBA1003021 1.72 2.09 5.98 8.49 8.58 6.67 * + HEMBA1003027 1.79 1.73 4.47 2.11 6.17 3.72 HEMBA1003029 16.39 17.36 46.06 37.07 42.91 45.58 HEMBA1003031 33.04 32.41 50.08 48.18 24.56 40.3 HEMBA1003032 3.42 6.52 7.98 8.81 6.53 9.45 HEMBA1003033 2.36 4.11 6.85 7.85 8.94 9 * + HEMBA1003034 2.43 3.17 7.63 8.24 7.47 8.23 HEMBA1003035 1.24 2 2.59 2.88 3.46 1.93 HEMBA1003037 1.74 2.09 6.21 4.13 7.36 3.43 HEMBA1003041 3.4 4.14 8.51 10.28 10.48 9 HEMBA1003046 11.44 11.53 28.31 33.77 21.19 36.32 HEMBA1003047 2.02 2.35 5.11 4.57 5.41 4.03 HEMBA1003048 1.8 2.96 3.76 7.97 7.47 9.3 ** + HEMBA1003064 3.7 4.12 15.74 15.78 25.09 19.36 HEMBA1003067 1.92 2.31 7.09 4.56 7.96 3.23 HEMBA1003071 5.24 5 8.74 11.32 10.02 8.7 HEMBA1003072 2.81 3.22 5.7 4.43 3.65 5.17 HEMBA1003076 20.6 21.34 31.6 41.86 28.3 32.74 HEMBA1003077 1.41 1.58 4.37 1.68 4.03 2.27 HEMBA1003078 2.02 1.92 2.4 3.14 4.9 3.38 * + HEMBA1003079 2.72 2.66 6.42 5.88 7.13 4.48 HEMBA1003083 1.56 2.11 3.94 4.42 6.23 4.59 HEMBA1003086 2.5 2.72 5.27 4.09 5.78 4.68 HEMBA1003090 5.14 4.79 13.3 11.57 12.88 12.73 HEMBA1003094 0.82 1.67 2.94 2.51 3.22 2.14 HEMBA1003096 8.6 8.76 15.55 10.1 13.7 10.97 HEMBA1003098 3.88 5.66 7.38 9.42 7.11 8.4 HEMBA1003101 4.73 5.48 7.29 9.04 6.59 6.36 HEMBA1003109 2.88 3.42 4.72 5.73 6.93 7.22 * + HEMBA1003114 2.87 4.67 5.67 6.47 7.94 5.69 HEMBA1003117 2.1 3.41 4.4 3.36 4.99 2.44 HEMBA1003120 3.02 2.65 5.55 3.23 7.38 4.29 HEMBA1003129 2.47 2.6 6.66 10.28 6.19 7.28 HEMBA1003133 2.05 4.74 7.61 7.74 7.59 5.59 HEMBA1003136 2.64 3.59 5.25 5.37 5.88 4.49 HEMBA1003142 2.01 2.27 6.15 6.62 6.35 5.34 HEMBA1003148 1.3 1.4 2.82 1.49 4.26 1.6 HEMBA1003151 1.91 2.08 4.23 2.9 5.34 4.24 HEMBA1003152 3.27 1.98 5.84 4.74 5.71 2.58 HEMBA1003157 1.23 1.88 2.58 4.2 5.38 3.21 * + HEMBA1003166 6.14 6.06 14.06 22.98 18.03 21.74 * + HEMBA1003171 1.3 2.28 2.23 2.62 3.09 2.53 HEMBA1003175 1.54 2.63 4.2 3.54 4.52 4.11 HEMBA1003179 4.66 5.95 37.4 36.91 43.86 45.13 HEMBA1003186 2.58 3.17 7.13 6.71 6.71 5.78 HEMBA1003196 3.04 3.79 7.33 6.95 8.31 5.18 HEMBA1003197 0.46 1.51 2.86 1.85 3.97 1.09 HEMBA1003199 1.26 1 2.32 1.66 3.22 2.47 HEMBA1003202 2.86 3.49 5.69 9.44 10.48 11.14 ** + HEMBA1003204 1.67 2.46 3.35 4.99 4.72 4.81 ** + HEMBA1003210 6.48 7.36 11.66 12.02 12.1 14.78 HEMBA1003212 1.4 2.87 5.52 7.58 8 5.7 HEMBA1003218 1.2 1.26 1.71 1.24 4.35 1.36 HEMBA1003220 34.65 32.6 73.43 78.35 79.82 83.89 HEMBA1003222 2.37 3.03 3.41 3.04 6.13 4.29 HEMBA1003225 1.95 2.07 3.34 1.59 3.45 2.05 HEMBA1003229 2.37 1.91 2.4 5.62 5.1 4.9 ** + HEMBA1003230 7.83 7.14 12.08 11.08 11.44 10.09 HEMBA1003235 0.91 1.33 4.32 4.98 5.25 5.44 * + HEMBA1003236 5.54 5.43 10.62 11.5 15.4 13.97 * + HEMBA1003250 1.41 1.4 2.68 1.76 2.98 2.42 HEMBA1003252 4.96 7.17 16.59 17.06 18.68 14.37 HEMBA1003257 2.7 3.33 7.33 8.25 8.83 6.78 HEMBA1003268 0.95 0.44 1.92 1.92 3.36 1.81 HEMBA1003273 1.4 1.38 2.96 2.5 3.37 5.1 HEMBA1003276 1.13 1.99 3.18 4.21 4.42 3.98 * + HEMBA1003277 0.95 0.83 1.85 0.56 1.63 1.34 HEMBA1003278 1.07 1.18 3.49 1 4.56 2.32 HEMBA1003280 2.37 2.6 4.59 3.08 4.91 4.2 HEMBA1003281 1.83 1.29 3.53 1.79 3.85 2.48 HEMBA1003284 1.24 1.91 3.43 3.03 5.05 3.32 HEMBA1003286 7.75 6.73 34.23 45.25 71.61 51.97 * + HEMBA1003291 1.65 1.91 4.84 3.21 3.32 3.25 HEMBA1003294 1.89 3.5 7.47 4.86 5.7 5.62 HEMBA1003296 4.74 8.32 46.61 63.82 70.23 54.45 * + HEMBA1003304 0.77 1.44 2.88 2.91 5.37 1.87 HEMBA1003306 4.37 6.3 10.28 15.7 17.76 11.56 * + HEMBA1003309 0.91 1.9 2.85 2.87 4 2.3 HEMBA1003314 1.43 2.26 3.82 4.48 3.52 4.02 HEMBA1003315 6.37 4.38 10.14 15.2 16.23 17.88 ** + HEMBA1003322 4.81 5.92 10.9 8.46 10.83 8.07 HEMBA1003326 1.94 3.97 5.55 2.93 7.4 3.68 HEMBA1003327 0.81 1.61 3.63 2.36 4.3 2.28 HEMBA1003328 0.76 2.43 5.38 4.25 5.51 5.06 HEMBA1003330 2.27 2.81 4.84 4.66 5.83 6.94 HEMBA1003348 3.22 2.45 11.3 11.28 13.98 16.37 HEMBA1003369 2.39 2.6 7 9.64 8.65 5.33 HEMBA1003370 3.14 3.6 8.85 12.54 10.83 13.98 * + HEMBA1003373 1.12 1.3 3.4 2.14 5.05 2.94 HEMBA1003376 3.75 2.83 7.71 9.83 12.46 10.39 * + HEMBA1003380 1.12 2.3 3.63 2.25 3.9 2.57 HEMBA1003384 0.98 1.71 2.91 2.11 4.78 2.14 HEMBA1003387 1.3 1.24 2.14 1.83 3.24 1.98 HEMBA1003392 2.51 2.28 3.43 5.21 5.91 4.44 * + HEMBA1003395 1.02 1.45 2.84 4.06 4.29 2.18 HEMBA1003399 1.03 1.4 3.27 3.21 3.26 2.19 HEMBA1003400 1.36 2.22 4.64 3.23 7.19 5.22 HEMBA1003402 1.62 1.74 3.29 2.32 4.22 2.59 HEMBA1003403 7.13 9.32 50.9 66.1 66.81 77.49 * + HEMBA1003408 3.68 4.5 7.27 6.02 5.77 7.71 HEMBA1003412 5.08 6.79 8.35 10.96 8.79 9.75 HEMBA1003417 5.71 6.5 10.15 8.18 8.86 7.36 HEMBA1003418 4.01 5.12 6.53 7.37 11.45 9.3 * + HEMBA1003420 16.29 17.91 35.46 33.32 34.37 32.89 HEMBA1003425 0.76 1.65 3.06 2.33 3.58 2.21 HEMBA1003433 1.4 2.43 3.34 4.88 4.54 4.09 * + HEMBA1003440 11.39 12.08 19.86 24.13 13.99 24.26 HEMBA1003442 4.37 4.67 4.94 3.54 6.73 5.96 HEMBA1003447 7.55 9.08 49.72 65.41 63.46 65.15 * + HEMBA1003453 21.03 22.03 42.15 27.85 29.02 27.64 HEMBA1003461 1.5 2.13 3.49 2.6 3.63 2.2 HEMBA1003463 2.82 3.68 6.02 5.97 3.84 6.41 HEMBA1003465 1.77 2.21 6.31 4.75 5.02 3.82 HEMBA1003480 2.58 3.91 8.62 9.63 9.6 9.42 HEMBA1003485 7.06 4.84 5.29 6.13 7.26 5.52 HEMBA1003487 1.8 1.85 3.4 7.12 6.39 6.79 ** + HEMBA1003492 1.42 1.95 4.11 2.41 5.87 2.1 HEMBA1003494 9.36 8.61 12.16 18.24 18.69 17.83 ** + HEMBA1003497 2.19 2.16 3.29 3.35 6.06 2.97 HEMBA1003503 0.98 1.74 3.37 5.04 3.18 2.13 HEMBA1003511 0.99 2.19 3.7 2.3 4.42 2.5 HEMBA1003528 3.33 4 6.51 5.77 5.04 4.46 HEMBA1003530 1.33 0.85 3.62 1.97 3.15 2.45 HEMBA1003531 1.14 1.72 5.39 4.74 7.24 4.51 HEMBA1003532 12.97 14.66 34.3 28.69 25.31 31.26 HEMBA1003538 2.54 2.4 17.88 14.54 21.58 16.83 HEMBA1003545 0.68 2.08 3.17 1.85 3.6 2.17 HEMBA1003546 1.27 2.03 1.68 1.98 2.15 2.42 HEMBA1003548 1.4 3.18 3.6 1.41 4.15 2.23 HEMBA1003553 31.29 31.45 47.99 54.36 41.34 45.65 HEMBA1003555 1.39 2.73 4.81 3.53 4.48 5.19 HEMBA1003556 1.24 1.76 2.96 3.14 5.75 3.31 HEMBA1003560 1.89 2.66 7.87 10.08 13.24 9.9 * + HEMBA1003565 54.27 66.88 96.28 121.29 139.88 148.68 * + HEMBA1003568 1.86 2.27 3.24 2.36 7.41 2.78 HEMBA1003569 2.93 2.61 2.96 5.07 3.95 4.53 ** + HEMBA1003571 3.53 2.33 3.8 5.19 5.3 5.83 * + HEMBA1003579 3.51 4.29 4.83 3.79 5.68 5.91 HEMBA1003580 3.82 4.09 4.96 3.11 4.41 3.53 HEMBA1003581 0.82 2.62 2.07 1.63 3.19 2.4 HEMBA1003591 10.8 11.44 30.24 33.74 35.7 36.88 * + HEMBA1003595 0.93 1.16 2.46 2.98 4.02 2.01 HEMBA1003597 3.15 3.18 8.74 10.82 11.39 11.59 * + HEMBA1003598 0.58 0.93 1.33 2.62 1.83 1.61 * + HEMBA1003600 3.71 4.19 13.35 14.77 13.86 16.69 HEMBA1003602 2.84 2.64 4.89 5.89 6.97 9.14 * + HEMBA1003604 2.3 3.35 5.67 6.63 8.29 8.16 * + HEMBA1003610 2.33 3.2 4.48 6.12 5.64 6.81 * + HEMBA1003615 1.76 2.61 5.23 4.95 5.21 4.96 HEMBA1003617 3.59 3.54 8.59 6.92 11.37 8.5 HEMBA1003620 5.76 6.01 4.98 13.48 17.69 12.58 ** + HEMBA1003621 1.6 1.66 3.19 4.52 5.42 5.08 ** + HEMBA1003622 0.96 0.69 1.38 1.47 3.17 2.25 HEMBA1003630 0.78 1.02 1.95 1.68 2.97 1.55 HEMBA1003637 0.66 1.93 2.59 2.11 3.11 2.63 HEMBA1003640 2.33 2.1 5.27 4.16 5.68 5.5 HEMBA1003645 1.12 1.2 4.41 2.3 3.82 3.06 HEMBA1003646 0.94 1.21 1.76 1.25 3.25 1.8 HEMBA1003647 0.49 2.15 3.27 2.46 3.79 2.21 HEMBA1003656 3.32 3.77 6.96 17.01 10.45 13.78 * + HEMBA1003662 1.37 2.08 1.54 5.2 3.81 4.91 ** + HEMBA1003666 23.84 17.7 51.57 21.97 21.85 24.71 HEMBA1003667 4.74 3.63 6.03 4.61 6.22 7.09 HEMBA1003670 0.83 0.65 1.94 1.18 2.61 1.51 HEMBA1003674 32.16 29.41 63.99 118.95 138.25 123.17 ** + HEMBA1003677 1.84 2.06 4.28 2.32 5.31 3.78 HEMBA1003679 1.2 1.68 3.72 2.22 6.19 3.23 HEMBA1003680 4.55 4.68 20.52 27.26 28.13 28.07 * + HEMBA1003684 1.57 1.9 3.98 4 3.65 4.47 HEMBA1003690 6.22 7.41 8.65 7.94 9.93 7.33 HEMBA1003692 2.41 3.82 7.23 8 8.28 7.7 HEMBA1003702 2.64 3.82 4.83 7.11 6.86 6.07 * + HEMBA1003711 1.06 1.21 3.39 2.93 3.88 2.37 HEMBA1003714 1.31 1.26 2.13 1.61 2.45 1.42 HEMBA1003715 1.46 2.7 6.58 10.21 9.15 6.87 * + HEMBA1003717 1.91 2.31 3.91 3.03 3.66 4.38 HEMBA1003720 0.81 2.6 5.07 4.16 4.16 4.21 HEMBA1003725 0.83 1.57 2.47 3.22 4.91 3.17 * + HEMBA1003728 1.28 2.48 3.4 2.65 4.36 2.72 HEMBA1003729 0.98 2.35 2.85 3.6 4.36 3.52 * + HEMBA1003732 1.11 1.52 3.49 3.01 2.75 1.88 HEMBA1003733 1.18 1.9 2.94 3.7 4.95 3.92 * + HEMBA1003742 5.15 7.3 5.95 21.53 22.58 19.56 ** + HEMBA1003743 1.37 1.76 3.21 4.13 4.36 3.68 * + HEMBA1003758 3.26 3.29 11.72 10.07 16.03 12.24 HEMBA1003760 0.82 2.43 3.09 1.92 4.19 3.16 HEMBA1003764 0.88 2.06 4.9 1.86 4.36 4.24 HEMBA1003769 6.61 8.95 15.57 22.58 17.05 20.77 * + HEMBA1003773 2.16 3.5 4.48 5.8 6.7 5.98 * + HEMBA1003783 3.12 3.11 4.95 8.58 8.64 8.27 ** + HEMBA1003784 0.46 1.37 2.89 2.37 2.45 1.77 HEMBA1003794 3.48 3.61 13.64 11.98 11.61 15.55 HEMBA1003799 1.09 1.05 4.29 2.44 5.06 3.76 HEMBA1003803 7.58 6.67 12.05 11.68 7.64 8.41 HEMBA1003804 1.08 2.53 4.45 1.86 3.35 2.05 HEMBA1003805 6.41 7.87 10.45 15.74 7.09 11.93 HEMBA1003807 1.52 1.53 3.21 2.71 6.32 2.37 HEMBA1003810 1.72 3.29 6.06 5.98 4.85 4.55 HEMBA1003827 2.71 4.55 12.08 13.28 10.48 15.35 HEMBA1003836 3.42 4.84 10.27 11.16 12.81 9.96 HEMBA1003838 16.58 16.15 31.32 34.24 33.25 35.46 HEMBA1003843 4.6 6.54 7.01 13.61 6.48 11.42 HEMBA1003846 19.54 21.94 61.32 72.86 70.58 83.4 * + HEMBA1003856 1.41 1.66 2.85 2.07 4.03 2.51 HEMBA1003857 2.89 3.1 5.85 5.89 8.29 6.88 HEMBA1003864 1.56 2.61 4.04 3.32 4.03 2.75 HEMBA1003866 0.89 0.75 2.21 1.66 2.23 0.73 HEMBA1003868 10.92 10.88 18.59 13.26 7.59 15.72 HEMBA1003879 0.95 1.33 3.16 3.49 4.42 3.09 HEMBA1003880 1.81 2.35 2.78 3.53 4.78 2.3 HEMBA1003884 10.97 11.37 39.03 54.69 62.46 57.8 * + HEMBA1003885 4.59 4.82 7.14 9.19 6.32 8.41 HEMBA1003887 3.58 4.93 7.7 8.65 7.93 8.18 HEMBA1003890 4.2 4.48 7.18 7.53 9.1 6.26 HEMBA1003893 4.38 6.39 9.53 8.75 13.24 9.94 HEMBA1003896 4.15 4.15 10.62 7.4 9.12 6.43 HEMBA1003902 1.39 3.78 5.09 4.91 6.42 5.1 HEMBA1003904 0.87 2.16 2.46 2.82 4.32 2.11 HEMBA1003908 1.18 1.3 2.89 2.12 5.25 1.43 HEMBA1003926 14.46 12.2 39.79 45.5 34.97 55.56 HEMBA1003937 2.75 3.31 5.38 4.3 6.85 4.57 HEMBA1003939 2.43 2.48 6.56 8.3 13.32 8.04 HEMBA1003940 2.45 3.08 5.01 4.29 6.22 5.55 HEMBA1003941 1.4 2.26 2.48 3.37 4.57 4.42 * + HEMBA1003942 1.63 2.88 3.13 2.01 3.85 2.22 HEMBA1003945 12.57 13.75 22.75 20.99 14.77 19.74 HEMBA1003949 1.4 1.9 3.53 3.29 6.22 4.14 HEMBA1003950 3.46 4.86 6.49 14.69 17.53 13.02 ** + HEMBA1003953 1.91 1.6 5.14 0.72 3.97 1.44 HEMBA1003958 5.16 3.6 7.47 7.54 9.45 6.64 HEMBA1003959 2.42 2.72 5.72 5.5 5.5 9.02 HEMBA1003960 3.25 5.81 34.7 24.04 26.4 28.28 HEMBA1003966 9.63 8.28 16.73 16.75 17.67 19.84 HEMBA1003967 1.75 3.06 3.47 3.48 3.6 3.27 HEMBA1003968 0.97 2.14 2.55 2.49 4.56 1.82 HEMBA1003974 634.2 699.64 821.36 986.231340.97 1248.21 * + HEMBA1003976 1.05 1.84 3.36 1.21 3.27 2.04 HEMBA1003977 1.48 2.07 1.99 1.41 3.49 2.15 HEMBA1003978 2.91 3.72 3.54 3.77 6.18 3.53 HEMBA1003981 9.01 6.77 14.06 12.05 11.49 18.27 HEMBA1003982 102.64 103.61 302.15 380.08 375.9 466.69 * + HEMBA1003985 1.18 1.9 2.43 3.21 3.79 2.18 HEMBA1003987 3.04 2.23 3.1 2.56 4.34 5.53 HEMBA1003989 1.62 1.77 4.56 3.79 5.12 3.31 HEMBA1004000 1.63 2.35 5.05 3.46 5.35 4.18 HEMBA1004006 2.79 2.88 12.86 16.29 22.13 19.73 * + HEMBA1004007 0.7 1.92 5.28 3.03 5.18 4.72 HEMBA1004010 67.4 61.25 98.24 112.56 96.78 136.86 HEMBA1004011 0.48 1.74 2.18 2.58 3.29 1.62 HEMBA1004012 0.79 1.84 2.3 3.11 4.8 3.53 * + HEMBA1004015 2.68 4.15 5.38 8.68 10.65 9.21 ** + HEMBA1004024 1.47 2.73 5.65 5.68 8.26 8.07 HEMBA1004029 1.93 3.1 3.03 4.6 8.38 13.11 HEMBA1004038 1.04 1.24 1.55 1.18 3.38 1.59 HEMBA1004042 0.89 1.42 2.22 1.58 4 2.48 HEMBA1004045 0.28 0.94 2.42 3.07 3.32 2.53 HEMBA1004048 4.16 4.16 12.1 19.93 14.84 22.3 * + HEMBA1004049 3.56 3.18 4.87 4.92 6.83 5.48 HEMBA1004051 136.19 118.77 205.49 243.62 283.22 223.29 * + HEMBA1004053 5.11 4.64 8.92 25.25 27.24 21 ** + HEMBA1004055 2.28 3.2 4.24 2.15 5.51 2.86 HEMBA1004056 3.78 3.07 6.73 5.3 10.99 9.56 HEMBA1004060 0.86 1 1.7 0.78 3.94 1.65 HEMBA1004061 4.76 3.94 6.44 7.37 12.64 8.57 HEMBA1004067 10.12 14.76 90.67 108.89 125.21 128.6 * + HEMBA1004071 7.51 7.77 16.52 17.31 12.23 13.37 HEMBA1004074 0.78 1.93 3.97 4.48 7.06 5.69 * + HEMBA1004078 3.87 2.95 5.22 6.52 6.2 6.87 * + HEMBA1004085 1.05 1.19 2.83 3.57 4.57 2.45 HEMBA1004086 3.38 4.95 6 8.92 8.09 6.51 * + HEMBA1004097 1.18 1.13 2.97 3.66 3.28 2.97 HEMBA1004100 3.85 4.81 8.96 6.9 9.64 9.55 HEMBA1004103 2 2.91 6.25 6.25 7.24 7.38 HEMBA1004110 3 3.77 5.43 4.18 4.23 5.02 HEMBA1004111 3.96 7.64 44.2 53.81 60.1 57.3 * + HEMBA1004124 7.14 10.51 60.12 83.27 97.96 83.59 * + HEMBA1004130 3.12 3.46 10.29 9.45 6.84 8.43 HEMBA1004131 2.14 2.12 3.06 4.08 3.73 3.21 * + HEMBA1004132 0.77 2.22 4.84 3.94 6.31 4.2 HEMBA1004133 0.69 1.77 2.56 3.28 5.17 3.22 HEMBA1004138 0.89 1.19 3.05 2.21 4.11 1.83 HEMBA1004143 7.1 7.48 17.43 18.83 15 17.6 HEMBA1004146 0.89 2.03 3.01 2.96 4.21 2.69 HEMBA1004148 1.85 1.57 2.13 2.25 3.38 1.99 HEMBA1004149 1.54 1.44 2.77 2.83 2.59 3.32 HEMBA1004150 0.49 1.06 2.15 2.31 1.58 1.08 HEMBA1004154 2.24 1.64 5.28 6.28 7.07 4.61 HEMBA1004164 1.84 2.23 5.63 6.89 7.13 5.81 HEMBA1004168 2.16 2.24 4.69 3.9 5.32 7.84 HEMBA1004199 1.37 1.92 2.34 3.17 3.66 1.8 HEMBA1004200 0.84 1.98 3 1.5 4.05 1.78 HEMBA1004201 4.87 5.68 17.64 26.94 32.17 25.65 * + HEMBA1004202 7.7 10.5 9.9 18.08 16.29 15.77 ** + HEMBA1004203 1.63 2.31 3.66 4.5 5.3 4.44 * + HEMBA1004207 1.9 3.24 3.62 5.73 6.23 6.2 ** + HEMBA1004210 1.13 1.72 2.67 1.95 4.14 1.87 HEMBA1004225 1.1 2.47 5.23 5.96 7.12 5.4 HEMBA1004227 2.17 4.44 3.86 5.14 5.71 5.16 HEMBA1004235 2.68 2.91 3.74 5.79 5.78 4.44 * + HEMBA1004237 3 3.31 5.23 5.95 4.67 5.47 HEMBA1004238 2.06 3.24 5.93 5.84 7.64 6.52 HEMBA1004241 2.32 3.09 3.87 2.74 3.74 3.35 HEMBA1004242 8.66 13.05 20.15 26.83 32.28 26.48 * + HEMBA1004243 1.8 2.09 3.58 2.8 3.03 2.76 HEMBA1004246 1.6 2.68 5.65 6.18 6.24 6.15 HEMBA1004247 0.89 2.73 3.74 3.69 4.23 3.37 HEMBA1004248 4.01 3.54 3.85 5.91 8.31 7.47 ** + HEMBA1004250 1.55 2.16 2.87 1.91 5.22 1.47 HEMBA1004252 3.57 3.27 4.8 4.64 5.79 4.28 HEMBA1004260 2.56 3.08 6.87 7.32 8.16 7.61 HEMBA1004264 1.26 2.11 2.59 2.16 2.86 1.37 HEMBA1004267 5.5 5.81 14.29 14.22 12.19 11.57 HEMBA1004272 1.75 2.31 3.31 2.26 3.84 2.04 HEMBA1004274 5.83 8.13 58.69 77.19 87.61 76.22 * + HEMBA1004275 1 5.4 3.34 1.49 4.49 2.42 HEMBA1004276 2.27 2.2 3.42 3.45 4.2 3.06 HEMBA1004279 2.13 2.33 4.37 3.29 5.2 3.88 HEMBA1004284 1.78 2.56 6.03 4.16 4.9 5.23 HEMBA1004286 1.41 1.35 2.44 1.65 3.55 2.1 HEMBA1004289 2.58 4.17 5.59 5.16 7.18 8.44 HEMBA1004293 20.24 18.64 51.03 77.3 52.39 74.25 * + HEMBA1004295 1.08 2.65 3.08 2.73 4.02 2.05 HEMBA1004302 0.72 1.84 2.29 1.21 3.39 1.49 HEMBA1004306 2.11 3.01 5.96 3.99 5.74 6.01 HEMBA1004312 1.3 1.58 4.98 3.57 3.56 3.56 HEMBA1004314 1.78 1.86 4.1 3.35 6.23 4.38 HEMBA1004321 0.88 1.66 2.56 4.05 4.15 4.82 ** + HEMBA1004323 2.4 3.16 4.7 4.77 5.29 5.1 HEMBA1004327 1.18 1.78 3.23 3.51 4.46 3.1 HEMBA1004329 5.57 6.73 15.22 16.29 15.33 15.14 HEMBA1004330 3.93 3.54 4.06 5.87 7.54 5.36 * + HEMBA1004334 2.92 3.63 4.69 4.18 4.74 6.06 HEMBA1004335 1.15 1.77 5.1 3.04 4.75 3.14 HEMBA1004341 1.01 1.1 1.25 1.13 3.34 1.14 HEMBA1004344 29.93 34.05 68.18 74.25 94.77 82.54 * + HEMBA1004347 0.67 1.65 2.21 2.31 2.25 2.78 HEMBA1004349 12.07 11.55 22.26 19.39 22.71 24.41 HEMBA1004352 2.06 2.56 6.96 6.05 6.92 6.58 HEMBA1004353 10.21 14.95 25.3 19.64 26.63 25.83 HEMBA1004354 1.9 2.56 6.29 5.42 6.94 5.83 HEMBA1004356 5.75 6.89 9.43 20.06 19.7 20.1 ** + HEMBA1004360 1.35 1.16 2.73 1.23 4.23 2.26 HEMBA1004366 1.97 1.91 3.57 4.53 6.9 4.73 * + HEMBA1004372 0.3 0.67 1.03 2.04 1.85 0.96 HEMBA1004377 6.57 5.58 10.48 16.45 11.58 13.72 * + HEMBA1004389 8.39 7.87 13.69 16.87 19.3 11.15 HEMBA1004391 1.18 0.88 1.37 1.27 4.23 2.34 HEMBA1004393 65.85 84.9 114.17 77.61 53.19 85.8 HEMBA1004394 0.84 1.14 1.88 1.68 3.9 2.59 HEMBA1004396 1.62 0.82 3.24 2.43 5.44 2.15 HEMBA1004401 4.33 4.37 5.25 8.95 14.42 11.05 * + HEMBA1004405 3.86 2.57 5.7 7.45 7.46 9.38 * + HEMBA1004408 4.27 2.66 5.34 7.19 8.8 9.85 * + HEMBA1004414 1.72 1.74 5.93 9.48 8.98 13.19 * + HEMBA1004429 2.95 3.96 4.23 4.68 6.9 6.8 * + HEMBA1004433 1.27 1.43 2.98 2.55 2.65 3.47 HEMBA1004440 1.33 1.33 2.62 2.3 2.63 1.79 HEMBA1004444 2.73 1.9 4.47 4.64 5.38 4.66 HEMBA1004446 1.37 0.95 2.26 1.84 2.94 3.19 HEMBA1004451 3.79 7.37 7.66 12.15 9.81 9.87 * + HEMBA1004452 0.71 1.96 2.89 3.53 8.91 2.36 HEMBA1004454 1.56 1.71 3.06 2.81 4.83 4.1 HEMBA1004460 1.91 3.49 7.49 4.39 6.91 5.19 HEMBA1004461 1 1.87 1.43 1.09 3.95 1.99 HEMBA1004468 3.22 4.71 7.36 9.92 12.73 8.79 * + HEMBA1004479 1.02 1.38 2.44 2.59 5.99 3.42 HEMBA1004482 2.77 1.93 5.5 5.62 5.83 5.6 HEMBA1004491 6.18 5.55 13 12.32 15.5 15.72 HEMBA1004499 9.09 12.56 65.85 86.22 91.62 102.95 * + HEMBA1004502 1.81 1.9 4.82 3.14 4.83 2.49 HEMBA1004505 1.57 2.42 4.6 4.78 7.66 4.09 HEMBA1004506 0.96 2.32 3.48 3.28 5.58 2.73 HEMBA1004507 29.33 30.94 74.36 85.26 112.08 83.25 * + HEMBA1004509 1.62 2.92 3.8 5.09 5.19 4.5 * + HEMBA1004523 1.04 1.68 1.65 1.82 3.64 3.02 HEMBA1004528 9.41 10.46 59.94 86.06 89.35 98.27 * + HEMBA1004534 6.43 9.06 20.99 14.78 16.24 20.46 HEMBA1004536 1.91 1.91 4.04 2.58 5.65 4.53 HEMBA1004538 10.84 12.11 16.22 14.06 12.69 14.98 HEMBA1004542 4.37 3.88 23.08 31.45 41.94 35.14 * + HEMBA1004552 2.98 1.35 4.27 9.89 9.44 7.1 ** + HEMBA1004554 1.21 1.05 2.53 1.91 7.29 2.16 HEMBA1004558 2.98 4.6 12.99 21.19 21.7 23.66 ** + HEMBA1004560 1.74 2.06 4.16 3.47 6.18 4.25 HEMBA1004564 4.31 3.3 8.73 7.27 9.96 8.65 HEMBA1004566 50.51 49.26 83.43 126.94 55.59 138.13 HEMBA1004573 1.07 1.97 3.91 2.91 4.11 2.3 HEMBA1004576 3.68 3.22 10.49 4.73 5.64 3.11 HEMBA1004577 6.11 7.2 14 11.74 13.04 10.71 HEMBA1004586 1.56 1.32 5.09 5.01 6.65 4.67 HEMBA1004596 3.97 3.19 19.1 27.4 39.04 32.16 * + HEMBA1004604 9.04 8.14 40.08 64.86 69.99 62.02 * + HEMBA1004607 0.96 1.97 4.17 3.02 4.39 3.96 HEMBA1004610 1.16 1.89 3.19 2.91 4.8 2.64 HEMBA1004617 0.78 0.89 3.29 2.77 4.53 2.51 HEMBA1004622 1.05 2.39 5.1 4.07 5.84 5.04 HEMBA1004626 1.56 2.36 4.75 4.06 4.93 2.33 HEMBA1004629 1.5 1.34 3.95 3.17 4.58 2.74 HEMBA1004631 1.57 1.73 4.41 3.3 5.73 4.97 HEMBA1004632 1.02 1.3 3.43 2.38 3.64 2.36 HEMBA1004633 3.2 3.98 8.84 9.3 9.04 10.74 HEMBA1004636 1.29 2.07 3.22 3.23 3.61 6.58 HEMBA1004637 1.57 2.12 4.19 3.97 4.85 2.39 HEMBA1004638 1.31 1.67 3.26 1.8 4.24 1.52 HEMBA1004645 3.04 2.88 6.5 5.07 6.21 5.08 HEMBA1004656 4.38 2.76 4.96 4.13 4.58 3.39 HEMBA1004657 16.78 17.12 35.48 31.85 17.55 22.74 HEMBA1004666 1.27 2.2 3.32 2.78 4.52 1.44 HEMBA1004669 2.49 3.6 6.16 7.32 8.34 5.55 HEMBA1004670 3.1 2.74 6.27 5.11 6.96 3.3 HEMBA1004672 1.29 2.33 4.85 2.58 7.25 3.63 HEMBA1004689 23.54 21.34 82.29 90.21 98.37 106.84 HEMBA1004690 4.74 5.24 15.26 19.89 22.39 20.76 * + HEMBA1004693 3.16 5.98 25.39 24.92 35.74 32.68 HEMBA1004697 1.64 1.96 4.88 7.14 9.69 4.03 HEMBA1004702 8.73 11.47 19.57 19.47 14.63 11.2 HEMBA1004704 1.9 3.35 9.01 3.41 5.17 5.36 HEMBA1004705 1.13 1.93 3.32 1.8 4.34 1.54 HEMBA1004706 1.34 2.4 3.89 4.31 6.23 4.7 HEMBA1004709 2.96 2.9 10.14 6.81 8.65 6.93 HEMBA1004711 1.22 1.44 5.01 1.19 3.14 3.28 HEMBA1004723 4.91 5.18 10.06 11.37 16.92 12.96 * + HEMBA1004725 4.14 4.9 7.68 5.67 8.62 8.54 HEMBA1004730 3.57 2.83 4.74 3.64 8.59 4.41 HEMBA1004733 1.07 2.64 2.62 1.06 3.54 2.45 HEMBA1004734 2.57 3.22 4.46 2.68 5.28 5.32 HEMBA1004736 1.1 1.89 7.12 3.87 12.1 5.09 HEMBA1004748 2.24 0.94 5.6 3.02 5.22 2.83 HEMBA1004749 6.88 8.33 19.68 16.49 19.03 23.29 HEMBA1004751 1.96 1.76 5.55 3.99 9.86 5.04 HEMBA1004752 1.51 1.6 4.23 4.56 4.11 3.32 HEMBA1004753 29.15 25.19 85.53 59.89 62.5 95.58 HEMBA1004755 7.02 6.32 12.37 9.73 12.72 14.63 HEMBA1004756 1.45 1.76 3.86 2.34 5.21 2.17 HEMBA1004758 1.18 1.64 4.53 3.92 5.65 3.17 HEMBA1004763 1.79 2.39 5.56 5.45 6.53 6.09 HEMBA1004768 0.83 1.64 2.89 1.69 4.26 1.38 HEMBA1004770 1.09 1.36 2.43 1.47 3.53 1.94 HEMBA1004771 0.99 1.02 2.44 2.18 3.26 2.57 HEMBA1004775 4.07 3.84 7.29 8.61 9.62 13.74 * + HEMBA1004776 1.86 3.21 3.33 3.95 6.83 6.04 * + HEMBA1004778 1.75 2.24 6.11 3.21 7.64 5.74 HEMBA1004784 1.51 1.59 3.11 2.36 4.18 3.62 HEMBA1004785 1 1.78 4.15 2.18 6.54 4.48 HEMBA1004789 2.34 2.07 4.42 1.87 5.64 2.87 HEMBA1004795 0.62 1.89 3.13 2.45 4.23 1.42 HEMBA1004797 1.06 0.84 1.85 2.31 2.85 2.76 * + HEMBA1004803 4.98 1.72 5.31 4.62 9.79 4.82 HEMBA1004806 1.23 1.78 3.22 2.36 3.83 2.33 HEMBA1004807 3.05 1.95 3.86 5.58 7.44 4.14 HEMBA1004816 4.73 2.61 3.59 3.78 7.97 9.34 HEMBA1004820 1.73 2.33 4.6 2.97 8.74 3.71 HEMBA1004833 1.22 1.23 5.54 2.71 6.95 4.37 HEMBA1004847 4.73 2.8 9.84 8 11.83 9.15 HEMBA1004850 1.01 1.78 6.15 6.56 13.54 6.38 HEMBA1004863 1.75 2.3 4.92 3.34 4.45 5.17 HEMBA1004864 2.66 3.91 6.68 4.19 9.03 6.51 HEMBA1004865 1.13 2.61 4.06 3.86 6.64 3.38 HEMBA1004880 2.22 3.32 9.22 9.9 10.38 9.48 HEMBA1004882 5.8 7.1 10.16 15.5 15.77 12.03 * + HEMBA1004885 2.34 6 8.67 8.58 8.67 9.27 HEMBA1004889 3.25 3.24 6.5 7.67 10.74 9.8 * + HEMBA1004900 1.51 1.59 3.71 3.21 5.14 2.84 HEMBA1004909 0.71 1.96 3.59 3.21 4.47 4.97 HEMBA1004918 1.46 1.7 4.93 4.03 7.19 5.77 HEMBA1004923 1.1 1.83 3.72 3.98 7.3 4.27 HEMBA1004929 1.01 1.7 2.68 1.66 3.59 1.38 HEMBA1004930 1.4 2.06 4.31 3.91 5.87 4.72 HEMBA1004933 2.41 1.5 5.32 5.59 5.43 3.38 HEMBA1004934 8.61 8.61 17.67 26.2 27.77 26.83 ** + HEMBA1004937 1.36 2.42 3.57 2.79 7.51 2.54 HEMBA1004943 1.11 1.75 3.63 2.56 4.88 3.68 HEMBA1004944 0.95 2.51 4.73 3.85 4.79 3.58 HEMBA1004946 4.78 4.38 12.5 12.69 14.08 12.8 HEMBA1004952 0.9 1.83 4.04 2.76 4.41 2 HEMBA1004954 3.55 3.21 7.92 6.02 6.4 6.12 HEMBA1004956 1.37 1.11 2.78 2.12 3.66 1.81 HEMBA1004960 0.86 0.75 3.27 4.17 6.72 3.06 HEMBA1004971 2.41 2.49 6.81 6.45 8.05 6.92 HEMBA1004972 2.57 2.31 3.63 2.07 5.66 5.84 HEMBA1004973 1.16 1.78 3.46 2.53 3.27 3.18 HEMBA1004977 3.04 3.08 5.36 5.34 6.29 6.36 HEMBA1004978 4.53 5.08 14.93 21.43 19.01 25.37 * + HEMBA1004980 1.92 2.36 7.92 6.55 6.55 7.29 HEMBA1004982 0.83 1.36 2.92 2.8 4.45 2.65 HEMBA1004983 1.73 1.88 4.29 3.92 5.5 4.21 HEMBA1004995 2.76 3.99 6.53 7.5 7.46 7.41 HEMBA1005004 1.63 3.57 5.12 3.45 5.72 4.07 HEMBA1005008 1.61 3.52 4.9 4.61 6.42 5.97 HEMBA1005009 4.55 3.9 8.37 11.95 6.96 9.22 HEMBA1005019 3.1 2.57 5.78 6.6 8.07 7.19 * + HEMBA1005021 16.12 17.89 30.44 29.81 23.38 23.26 HEMBA1005029 3.13 3.42 7.98 7.23 8.66 6.52 HEMBA1005035 6.53 6.29 19.38 18.59 17.77 20.38 HEMBA1005036 19.87 20.39 37.72 23.12 19.26 26.98 HEMBA1005039 1.7 3.19 4.59 4.36 6.81 3.69 HEMBA1005047 4.31 4.06 5.6 7.01 8.54 7.83 ** + HEMBA1005050 2 2.93 5.07 4.33 6.76 4.39 HEMBA1005062 2.48 3.06 5.62 2.85 5.13 2.03 HEMBA1005066 2.28 2.55 5.72 4.81 8.94 6.89 HEMBA1005067 5.81 10.37 17.44 25.77 30.77 26.84 * + HEMBA1005070 3.33 3.01 8.9 8.51 8.13 6.59 HEMBA1005075 1.29 2.45 6.51 3.97 5.38 4.49 HEMBA1005078 7.47 6.74 14.34 14.89 9.95 11.01 HEMBA1005079 5.52 5.68 13.65 14.98 16.02 21.42 HEMBA1005083 0.94 0.97 2.69 2.17 4.96 1.25 HEMBA1005084 5.36 4.49 8.84 7.48 10.38 9.99 HEMBA1005088 1.63 1.64 7.16 3.48 6.18 4.54 HEMBA1005089 3.12 3.47 5.53 5.04 9 5.52 HEMBA1005090 5.92 5.56 11.7 17.14 12.91 21.06 * + HEMBA1005096 0.88 2.47 3.98 3.35 3.94 2.88 HEMBA1005101 2.29 2.08 4.54 3.23 5.6 4.54 HEMBA1005107 1.2 1.92 3.2 2.25 4.48 2.3 HEMBA1005113 0.96 2.18 3.35 2.12 5.53 2.72 HEMBA1005123 3.35 3.46 10.83 9.05 10.41 8.28 HEMBA1005133 2.6 2.26 7.59 5.11 4.58 7.09 HEMBA1005135 1.19 2.77 3.35 1.47 5.28 3.69 HEMBA1005145 5.84 6.38 12.56 13.06 14.71 17.84 HEMBA1005149 4.21 3.2 7.92 6.51 8.54 8.47 HEMBA1005152 1.81 3.06 3.59 3.31 5.05 3.39 HEMBA1005159 1.76 1.96 3.62 2.2 8.12 2.2 HEMBA1005172 120.6 113.48 240.76 174.65 194.57 222.24 HEMBA1005185 3.16 2.05 4.47 3.54 6.7 4.15 HEMBA1005186 1.55 2.65 3.96 3.52 8.39 2.03 HEMBA1005195 2.15 1.08 3.76 1.93 6.73 2.24 HEMBA1005201 3.27 3.45 8.02 5.52 7.17 8.91 HEMBA1005202 5.93 4.58 9.4 8.29 9.76 12.83 HEMBA1005204 86.99 67.86 141.56 134.68 133.57 172.39 HEMBA1005206 6.39 5.08 66.26 72.89 92.07 89.66 * + HEMBA1005219 4.62 6.56 14.55 15.66 21.85 17.87 * + HEMBA1005223 2.4 1.91 4.92 1.7 3.83 3.86 HEMBA1005229 1.18 2.32 3.12 1.57 4.88 2.32 HEMBA1005230 1.22 1.56 4.24 2.71 5.92 4.32 HEMBA1005232 0.86 1.13 1.6 0.91 3.81 2.17 HEMBA1005238 0.84 1.77 2.67 2.16 3.27 2.29 HEMBA1005241 2.77 2.68 7.42 7.63 11.38 7.62 HEMBA1005244 0.87 1.97 5.63 2.57 8.33 6.19 HEMBA1005246 8.84 7.84 17.94 12.96 18.21 14.79 HEMBA1005251 3.06 2.57 6.81 6.6 8.47 7.24 HEMBA1005252 2.3 2.7 5.31 4.73 11.4 5.01 HEMBA1005267 2.77 3.31 7.25 6.77 12.66 9.89 HEMBA1005274 1.75 1.53 3.28 4.8 6.38 6.51 ** + HEMBA1005275 0.62 1.27 1.59 1.63 3.44 2.12 HEMBA1005288 3.03 1.16 6.1 6.49 6.35 6.68 HEMBA1005293 1.46 1.37 2.53 1.5 4.09 1.78 HEMBA1005296 440.88 422.67 780.14 598.1 568.79 483.77 HEMBA1005301 3.93 3.26 29.41 28.17 47.57 44.12 HEMBA1005304 1.75 2.3 7 3.36 7.29 7.62 HEMBA1005305 0.77 1.18 2.57 0.74 3.99 1.71 HEMBA1005311 0.97 1.05 2.08 0.81 1.97 2.13 HEMBA1005313 20.35 21.96 39.64 29.02 19.54 26.39 HEMBA1005314 1 1.36 2.6 2.2 4.08 1.99 HEMBA1005315 0.81 2.41 4.27 1.95 5.32 3.59 HEMBA1005317 0.8 1.48 2.93 1.9 3.68 2.43 HEMBA1005318 1.42 0.95 2.68 1.48 4.54 2.21 HEMBA1005324 6.24 8.79 28.39 48.36 52.86 57.05 ** + HEMBA1005331 2.77 5.64 15.05 21.73 18.68 21.33 * + HEMBA1005337 12.1 12.25 61.94 98.25 113.65 125.54 * + HEMBA1005338 4.53 4.54 27.15 34.04 35.53 42.4 * + HEMBA1005344 2.75 2.57 5.08 4.17 4.16 3.3 HEMBA1005353 1.15 2.78 6.52 4.66 7.21 6.44 HEMBA1005359 2.6 2.82 7.48 6.59 8.03 7.68 HEMBA1005362 1.06 2.73 4.93 7.3 11.27 8.37 * + HEMBA1005364 0.96 1.48 3 2.55 3.78 2.75 HEMBA1005367 0.96 1.53 4.19 3.3 4.21 2.99 HEMBA1005372 1 2.24 4.18 2.3 5.1 3 HEMBA1005374 2.29 3.31 7.83 6.4 6.45 8.09 HEMBA1005379 3.19 3.61 7.65 29.57 25.57 24.46 ** + HEMBA1005382 9.85 11.52 79.62 88.72 86.53 120.52 HEMBA1005384 1.44 1.76 3.4 2.78 3.74 2.78 HEMBA1005386 1.52 2.67 4.54 4.17 4.66 4.84 HEMBA1005389 1.1 0.8 3.01 2.51 4.09 3.75 HEMBA1005394 1.64 2.32 5 8.09 10.03 6.99 * + HEMBA1005403 4.19 4.24 8.81 8.46 11.37 8.87 HEMBA1005408 1.43 1.71 5.3 4.52 7.12 6.96 HEMBA1005410 1.06 1.74 3.22 1.78 4.97 2.42 HEMBA1005411 1.38 2.58 4.54 2.84 4.09 2.74 HEMBA1005423 4.14 5.87 4.72 12.75 8.59 11.04 * + HEMBA1005426 0.71 1.79 2.35 2.08 3.25 4.15 HEMBA1005427 9.12 12.47 24.08 37.26 33.57 35.43 * + HEMBA1005430 1.71 1.43 3.23 3.26 4.07 4.78 HEMBA1005438 1.42 2.33 4.26 4.01 5.41 2.66 HEMBA1005443 15.57 16.88 35.83 20.61 27.42 29.93 HEMBA1005447 1.55 1.95 3.42 2.25 5.9 3 HEMBA1005449 1.5 1.36 3.29 1.82 5.83 3.21 HEMBA1005452 8.96 10.79 63.65 107.56 94.42 105.84 * + HEMBA1005454 4.73 4.51 7.91 6.37 8.12 5.33 HEMBA1005468 2.49 3.19 4 3.6 4.93 4.86 HEMBA1005469 1.39 1.89 5.38 3.44 5.94 4.04 HEMBA1005472 4.04 4.76 7.81 6.79 6.75 8.2 HEMBA1005474 4.91 5.42 11.67 7.77 9.4 9.23 HEMBA1005475 7.8 7.09 11.75 15.34 10.75 13.59 HEMBA1005489 2.47 3.48 4.94 6.34 7 6.54 * + HEMBA1005497 0.65 1.97 3.47 2.86 4.42 2.14 HEMBA1005500 4.64 4.25 11.48 9.17 13.98 10.59 HEMBA1005506 3.88 2.15 4.02 2.71 3.57 1.29 HEMBA1005508 5.79 7.67 13.3 11.65 14.52 10.99 HEMBA1005511 2.97 2.29 9 4.36 6.36 6.14 HEMBA1005513 6.3 9.05 55.46 50.46 60.73 57.45 HEMBA1005517 1.8 2.89 3.88 4.37 6.41 3.74 HEMBA1005518 1.48 2.49 3.94 2.94 5.22 2.3 HEMBA1005520 1.89 3.19 8.8 8.37 10.13 9.32 HEMBA1005522 1.78 2.29 3.37 2.52 4.72 1.45 HEMBA1005526 3.24 2.8 6.25 4.37 7.26 4.58 HEMBA1005528 8.59 16.13 16.28 20.24 22.18 20.01 HEMBA1005530 2.28 3.62 5.13 4.91 7.75 4.51 HEMBA1005538 11.07 10.7 15.34 8.46 4.44 5.89 * - HEMBA1005539 30.73 31.96 63.32 50.52 49.29 34.26 HEMBA1005545 1.2 1.08 3 4.28 6.22 2.25 HEMBA1005548 2.38 2.88 11.1 11.04 12.72 9.21 HEMBA1005552 2.76 4.58 12.05 9.13 12.8 10.25 HEMBA1005558 1.59 2 5.86 2.18 6.97 4.17 HEMBA1005568 3.11 2.96 8.24 6.28 8.45 7.5 HEMBA1005570 1.87 2.75 3 1.96 4.49 7.13 HEMBA1005576 1.74 2.8 2.4 3.03 3.55 3.57 * + HEMBA1005577 1.14 2.02 2.78 0.95 3.08 0.87 HEMBA1005581 4.29 4.22 6.85 14.27 18.37 8.15 HEMBA1005582 2.74 2.57 5.35 3.25 7.91 3.21 HEMBA1005583 2.47 3.31 5.86 3.32 6.43 3.44 HEMBA1005588 2.51 2.85 6.27 5 6.54 6.14 HEMBA1005593 1.5 1.4 2.85 1.83 4.57 2.89 HEMBA1005595 2.62 2.82 4.15 3.31 4.65 4.76 HEMBA1005597 4.77 5.18 8.13 9.39 10.34 8.64 * + HEMBA1005606 2.29 2.76 5.79 3.96 6.91 5.83 HEMBA1005609 2.84 2.64 6.61 4.19 5.77 6.81 HEMBA1005616 2.01 1.66 8.03 5.44 8.75 7.03 HEMBA1005621 2.43 1.91 4.42 4.13 6.24 2.7 HEMBA1005627 3.84 3.92 11.61 9.73 15.14 14.89 HEMBA1005628 12.1 12.91 20.55 17.92 23.35 18.08 HEMBA1005631 13.47 11.94 26.82 22.77 22.87 29.03 HEMBA1005632 1.33 2.33 5.06 3.14 3.68 4.47 HEMBA1005634 3.06 3.42 5.15 2.81 7.68 5.18 HEMBA1005662 1.18 1.27 3.17 1.06 4.57 3.03 HEMBA1005666 5.89 4.51 10.09 10.5 9.01 10.25 HEMBA1005670 1 1.08 4.06 2.87 4.35 3.19 HEMBA1005671 2.11 3.38 5.07 5.36 9 5.9 HEMBA1005679 2.33 4.64 7.39 6.5 10.44 10.19 HEMBA1005680 2.63 2.14 5.9 5.51 7.59 7.72 HEMBA1005685 2 1.89 7.27 3.8 6.73 1.97 HEMBA1005698 5.96 4.75 12.88 11.78 14.17 9.93 HEMBA1005699 1.4 1 2.45 2.17 3.66 2.96 HEMBA1005703 1.22 1.27 3.57 1.79 3.56 1.88 HEMBA1005705 2.39 2.78 6.45 3.41 6.27 3.89 HEMBA1005712 1.23 1.34 4.52 2.18 4.84 2.37 HEMBA1005717 1.55 1.89 4.7 1.34 5.36 2.16 HEMBA1005718 5.27 4.35 7.8 10.09 10 15.72 * + HEMBA1005721 15.93 20.34 26.12 37.74 25.37 32.79 HEMBA1005722 18 19.32 35.72 25.36 30.28 26.91 HEMBA1005724 2.17 2.05 4.6 2.47 6.56 2.98 HEMBA1005732 1.33 1.54 4.89 7.22 8.38 5.67 * + HEMBA1005737 1.49 1.19 2.95 2.44 4.57 1.75 HEMBA1005742 3.4 4.65 5.7 4.43 6.35 4.22 HEMBA1005746 1.2 1.61 3.23 5.69 4.42 4.85 * + HEMBA1005747 3.8 3.51 7.52 6.08 6.55 6.67 HEMBA1005749 9.64 9.37 17.99 21.62 19.82 18.15 HEMBA1005755 0.49 2.5 3.35 1.66 4.41 2.9 HEMBA1005760 1.59 2.1 5.37 3.7 4.86 4.14 HEMBA1005765 1.47 2.89 5.97 5.91 7.42 7.21 HEMBA1005766 8.52 10.49 61.64 93.4 112.09 106.28 * + HEMBA1005780 4.98 5.15 14.49 13.93 16.26 12 HEMBA1005795 1.15 1.8 3.71 4.28 5.45 4.26 * + HEMBA1005809 9.13 9.7 20.95 14.79 29.83 22.75 HEMBA1005813 1.76 2.74 6.74 5.39 9 7.08 HEMBA1005815 0.62 1.86 2.75 2.74 4.78 2.13 HEMBA1005822 1.34 2.83 5.82 3.77 6.65 5.12 HEMBA1005829 1.49 2.66 4.94 5.11 4.53 5.52 HEMBA1005833 1.83 1.28 4.41 3.89 5.17 4.57 HEMBA1005834 2.53 1.87 4.84 5.48 11.84 6.81 HEMBA1005844 27.89 31.06 52.5 62.42 59.49 58.73 * + HEMBA1005852 5.75 4.18 10.12 10.15 12.34 11.51 HEMBA1005853 2.81 3.05 9.32 5.68 13.84 9.26 HEMBA1005878 4.42 4.52 10.14 8.84 10.05 11.01 HEMBA1005883 1.67 2.81 4.56 2.81 5.43 4.01 HEMBA1005884 1.87 2 3.21 2.27 5.9 2.28 HEMBA1005891 2.39 3.04 3.59 4.34 5.46 3.95 HEMBA1005894 2.12 2.41 8.68 8.23 9.08 6.9 HEMBA1005898 4.52 3.75 7.4 10.51 10.74 9.53 * + HEMBA1005902 2.57 3.14 8.63 5.36 6.75 5.82 HEMBA1005907 1.15 2.28 2.2 2.28 4.2 1.74 HEMBA1005909 0.93 2.68 2.97 2.96 4.55 2.6 HEMBA1005911 1.66 3.12 4.9 3.96 9.5 3.41 HEMBA1005912 8.83 7.86 13.57 16.44 8.16 15.58 HEMBA1005913 5.05 5.39 10.39 9.57 7.71 7.06 HEMBA1005921 2.36 3.86 6.29 5.25 10.06 7.64 HEMBA1005922 5.49 5.47 6.99 8.51 10.1 8.74 * + HEMBA1005929 1.91 2.53 7.53 5.05 5.68 6.47 HEMBA1005931 3.32 2.95 6.04 5.31 9.49 6.09 HEMBA1005934 2.9 4.69 8.2 8.17 10.14 9.73 HEMBA1005945 3.1 4.12 7.73 6.36 9.39 6.65 HEMBA1005962 1.72 1.81 3.16 1.93 3.96 1.72 HEMBA1005963 1.86 1.67 3.91 2.26 3.95 2.05 HEMBA1005990 6.04 7.39 17.86 14.14 16.18 17.02 HEMBA1005991 2.39 3.35 8.55 7.2 7.64 6.94 HEMBA1005999 2.34 4.39 8.84 6.52 8.18 8.75 HEMBA1006002 3.53 5 7.73 5.96 10.24 8.99 HEMBA1006005 0.96 2.31 3.93 2.87 5.65 3.27 HEMBA1006011 26.27 24.03 34.08 62.88 44.8 64.92 * + HEMBA1006013 2.43 2.57 6.31 4.17 6.87 3.74 HEMBA1006016 1.65 1.98 5.64 3.22 5.34 2.16 HEMBA1006019 2.97 3.23 6.91 4.46 7.22 5.44 HEMBA1006021 5.06 6.45 9.21 10.29 12.48 8.77 HEMBA1006022 3.19 4.34 6.89 6.52 6.1 5.94 HEMBA1006031 1.32 2.46 4.38 3.72 5.57 5.34 HEMBA1006035 3.05 3.72 7.96 4.99 6.37 4.54 HEMBA1006036 2.02 2.3 7 4.27 10.14 7.22 HEMBA1006042 3.36 3.1 8.51 5.76 9.59 8.31 HEMBA1006044 1.44 1.99 3.61 2.8 3.4 1.67 HEMBA1006045 1.98 1.99 5.08 4.3 8.55 5.64 HEMBA1006048 2.42 4.18 5.41 6.84 7.96 8.18 * + HEMBA1006053 1.51 2.72 3.55 3.09 3.3 3.93 HEMBA1006055 1.84 1.91 2.46 3.04 4.92 3.67 * + HEMBA1006058 4.04 4.62 11.59 7.42 10.66 12.41 HEMBA1006063 9.2 9.36 32.62 26.37 33.39 27.19 HEMBA1006067 4.14 3.27 5.81 5.8 8.4 7.17 HEMBA1006081 0.84 2.59 4.77 2.54 7.08 2.49 HEMBA1006089 2.58 4.48 6.82 8.28 10.12 9.66 * + HEMBA1006090 1.66 2.31 2.28 1.66 5.26 1.84 HEMBA1006091 1.1 1.35 1.75 3.15 4.31 2.95 * + HEMBA1006093 1.65 1.77 4.21 2.27 6.67 4.26 HEMBA1006099 11.9 9.88 23.12 21.57 16.43 20.57 HEMBA1006100 2.78 3.18 13.25 8.38 15.71 13.52 HEMBA1006108 2.69 2.08 4.22 3.42 5.24 3.75 HEMBA1006114 7.21 8.76 39.36 34.51 62.97 50.98 HEMBA1006121 1.18 1.8 3.13 2.43 5.83 2.91 HEMBA1006124 1.79 1.74 4.47 3.11 4.89 4.13 HEMBA1006125 18.52 14.19 23.44 25.23 22.56 34.45 HEMBA1006130 5.15 3.1 7.57 6.89 7.84 9.51 HEMBA1006138 2.43 2.41 5.55 5.27 9.2 8.12 HEMBA1006142 2.62 1.87 6.23 6.67 9.36 8.91 * + HEMBA1006150 8.32 7.44 21.06 20.42 21.82 24.68 HEMBA1006151 567.67 524.4 796.07 915.23 875.11 682.15 HEMBA1006155 0.93 1.33 2.92 1.44 5.54 1.94 HEMBA1006158 3.06 4.95 7.5 5.7 9.04 6.31 HEMBA1006164 2.61 1.96 5.89 5.26 4.54 5.82 HEMBA1006171 29.76 24.08 54.44 32.3 33.25 34 HEMBA1006173 5.15 3.15 30.41 36.16 55.46 57.62 * + HEMBA1006176 315.12 232.27 427.53 476.77 458.01 381.49 HEMBA1006182 1.47 1.71 6.13 3.02 5.84 5.82 HEMBA1006197 6.14 5.09 9.26 9.53 12.1 10.41 HEMBA1006198 10.07 6.46 26.71 35.03 45.64 55.68 * + HEMBA1006213 1.98 1.78 2.4 2.33 2.69 2.3 HEMBA1006217 44.9 41.62 72.62 94.44 74.92 78.25 HEMBA1006226 40.86 36.82 63.27 77.37 79.96 57.39 HEMBA1006235 2.13 1.96 4.34 2.6 5.85 2.32 HEMBA1006248 1.74 2.03 4.04 3.37 6.4 2.95 HEMBA1006251 5.41 7.29 7.88 11.96 12.95 9.22 * + HEMBA1006252 0.72 1.28 3.67 2.25 3.56 2.92 HEMBA1006253 2.13 2.26 4.1 5.93 5.38 5.76 * + HEMBA1006259 1.96 2.29 6.02 5.7 3.9 5.32 HEMBA1006261 12.25 7.27 18.84 14.23 14.08 13.61 HEMBA1006268 2.05 2.56 3.86 4.83 5.09 4.06 * + HEMBA1006271 2.04 3.99 10.58 7.13 9.33 8.51 HEMBA1006272 0.97 2.26 2.84 2.38 6.01 1.93 HEMBA1006273 1.53 2.09 4.55 3.58 4.52 2.46 HEMBA1006276 2.8 1.26 3.62 4.45 5.84 2.82 HEMBA1006278 1.57 2.03 3.19 4.08 4.51 2.72 HEMBA1006283 3.09 3 6.08 7.34 11.13 7.09 HEMBA1006284 2.47 1.57 3.14 4.75 6.96 2.82 HEMBA1006291 1.42 2.56 4.41 4.6 6.16 2.57 HEMBA1006292 3.36 5.12 17.34 19.95 23.83 21.11 * + HEMBA1006293 1.83 1.46 3.19 2.92 4.02 1.36 HEMBA1006299 1.92 2.26 7.03 5.02 6.39 4.74 HEMBA1006309 2.26 1.43 3.53 4.47 4.69 3.73 * + HEMBA1006310 4.14 4.32 7.72 9.51 8.34 5.7 HEMBA1006311 1.4 2.33 6.68 5.59 5.85 5.72 HEMBA1006313 1.2 1.6 2.74 4.29 4.68 2.26 HEMBA1006316 2.16 3.08 6.72 6.63 6.28 5.59 HEMBA1006328 2.78 4.28 13.48 15.14 17 16.56 HEMBA1006334 1.46 3.1 2.77 2.79 3.95 2.05 HEMBA1006335 10.42 13.98 21.66 20.81 18.03 16.77 HEMBA1006344 2.86 3.55 6.9 7.18 6.88 5.75 HEMBA1006347 2.04 1.83 4.2 2.94 2.76 1.68 HEMBA1006349 2.47 2.79 6.73 3.62 5.65 3.5 HEMBA1006352 1.65 1.65 3.27 2.63 5.64 1.32 HEMBA1006357 4.99 4.26 8.6 8.36 7.8 7.74 HEMBA1006358 1.67 2.57 4.95 4.7 5.11 5.63 HEMBA1006359 1.56 2.17 4.02 3.67 5.48 3.3 HEMBA1006360 2.53 2.12 5.1 9.73 10.02 8.61 ** + HEMBA1006364 1.71 2.76 4.82 4.02 5.55 3.51 HEMBA1006377 5.8 8.03 13.25 20.48 16.19 15.31 * + HEMBA1006380 1.31 1.57 8.75 6.78 7.01 6.9 HEMBA1006381 2.38 3.07 12.65 6.18 7.97 6.66 HEMBA1006385 3.21 3.33 8.65 5.41 8.17 5.32 HEMBA1006390 9.49 7.85 14.66 22.01 20.52 22.7 ** + HEMBA1006391 6.58 6.85 6.73 12.83 10.12 13.15 ** + HEMBA1006398 1.32 1.67 4.19 2.57 4.12 1.69 HEMBA1006405 23.81 23.5 38.82 23.85 22.13 24.92 HEMBA1006410 8.26 4.16 6.14 5.74 11.61 6.06 HEMBA1006416 2.14 2.62 5.93 5.3 6.98 4.23 HEMBA1006418 5.06 5.49 11.76 8.17 8.09 5.92 HEMBA1006419 2.67 3.93 8 6.89 7.77 5.2 HEMBA1006421 2.03 3.28 3.09 3.44 4.19 2.27 HEMBA1006424 1.48 1.92 3.59 1.94 5.42 1.84 HEMBA1006426 3.03 3.99 7.91 7.23 7.87 5.51 HEMBA1006430 2.31 2.64 6.29 5.89 7.43 5.08 HEMBA1006438 2.06 2.22 6.35 4.37 6.53 2.92 HEMBA1006445 1.98 2.68 5.72 6.11 5.6 4.16 HEMBA1006446 1.32 2.61 5.59 2 6.51 2.43 HEMBA1006456 3.51 5.07 8.64 14.9 21.76 15.91 * + HEMBA1006461 1.54 2.18 5.35 4.35 5.49 4.07 HEMBA1006467 1.52 1.78 3.61 2.82 7.24 3.2 HEMBA1006470 4.06 4.03 22.46 18.72 29.54 19.52 HEMBA1006471 1.58 1.6 6.6 6.45 6.78 6.26 HEMBA1006474 7.35 6.37 43.12 55.87 62.01 52.31 * + HEMBA1006476 9.48 10.05 66.66 94.3 119.21 92.71 * + HEMBA1006482 71.42 71.44 219.31 199.96 180.73 192.88 HEMBA1006483 2.03 2.96 7.22 3.36 4.88 3.24 HEMBA1006485 2.24 1.72 6.31 4.09 6.53 5.51 HEMBA1006486 5.08 5.55 13.73 18.4 16 15.46 * + HEMBA1006489 1.21 2.18 4.1 3.18 5.4 2.17 HEMBA1006492 5.34 7.71 10.69 15.16 24.33 15.92 * + HEMBA1006494 1.27 1.18 2.67 2.44 3.88 1.86 HEMBA1006497 1.67 2.33 4.75 4.3 3.79 4.49 HEMBA1006501 7.61 7.52 62.05 58.03 78.37 58.59 HEMBA1006502 4.73 3.55 15.72 18.66 22.55 21.66 * + HEMBA1006507 8.7 6.8 51 49.69 71.2 48.41 HEMBA1006517 1.51 1.99 5.07 3.43 5.9 4.64 HEMBA1006521 1.79 1.8 4 2.41 4.55 3.02 HEMBA1006529 4.77 3.74 3.86 5.97 5.83 2.78 HEMBA1006530 1.8 1.39 2.06 1.62 3.53 2.42 HEMBA1006535 1.66 1.43 2.01 2.66 2.81 2.43 ** + HEMBA1006536 0.59 2.22 3.96 3.04 3.23 2.33 HEMBA1006540 1.61 1.68 3.33 3.05 4.1 3.56 HEMBA1006544 1.39 1.63 8 3.54 5.85 4.35 HEMBA1006546 2.06 2.56 6.98 4.25 5.77 4.51 HEMBA1006549 1.74 2.13 5.93 4.57 4.63 4.61 HEMBA1006559 2.55 1.45 4.63 2.99 5.76 3.32 HEMBA1006562 0.74 1.32 4.07 2.39 5.24 2.72 HEMBA1006566 0.67 1.28 0.97 1.34 1.69 0.99 HEMBA1006569 2.33 1.36 3.97 3.25 3.89 4.02 HEMBA1006572 1.02 2.38 2.94 2.68 3.92 2.01 HEMBA1006579 20.44 16.82 51.93 59.14 66.28 72.54 * + HEMBA1006583 3.17 2.85 5.59 5.83 5.94 6.45 HEMBA1006595 1.82 1.63 4.29 2.83 5.22 3.68 HEMBA1006597 1.65 2.1 5.34 3.81 6.75 3.77 HEMBA1006606 1.75 2.31 4.96 3.72 5.71 2.8 HEMBA1006612 2.63 3.54 7.11 7.32 5.31 7.07 HEMBA1006617 1.93 2.58 6.24 4.62 4.6 5.41 HEMBA1006624 6.37 8.61 16.93 12.84 15.78 10.91 HEMBA1006631 3.24 3.13 8.01 8.11 11.54 6.97 HEMBA1006635 1.7 2.57 5.7 4.27 6.27 3.8 HEMBA1006639 1.12 1.98 4.52 4.14 5.3 3.06 HEMBA1006643 1.88 1.23 1.85 2.12 3.81 2.17 HEMBA1006648 7.69 6.84 16.92 17.63 23.57 23.73 * + HEMBA1006652 5.96 7.86 16.11 16.41 16.83 17.34 HEMBA1006653 2.21 3.66 7.23 6.92 5.18 5.17 HEMBA1006658 5.04 6.58 12.68 14.07 13.59 12.01 HEMBA1006659 6.8 10.14 48.92 66.47 78.17 67.44 * + HEMBA1006665 1.44 0.89 3.32 2.77 2.91 1.82 HEMBA1006666 1.83 1.25 3.23 3.24 4.14 2.45 HEMBA1006671 8.69 6.74 11.66 17.25 16.13 15.21 ** + HEMBA1006674 1.64 1.99 7.42 6.71 9.73 7.34 HEMBA1006676 1.46 2.36 5.19 4.28 6.75 3.19 HEMBA1006682 2.17 1.64 3.43 2.2 4.98 1.88 HEMBA1006688 1.48 2.46 4.74 3.31 4.38 3.54 HEMBA1006695 1.58 2.41 4.85 3.54 5.79 2.46 HEMBA1006696 2.84 3.93 6.29 5.95 6.74 5.82 HEMBA1006702 3.31 1.83 13.28 4.13 5.58 4.87 HEMBA1006707 2.89 2.62 5.9 5.04 7.54 5.5 HEMBA1006708 2.21 1.52 5.71 4.42 4.57 2.63 HEMBA1006709 1.64 1.97 4.6 4.29 5 4.74 HEMBA1006717 1.58 2.28 3.58 2.5 4.93 2.28 HEMBA1006724 2.68 3.42 4.55 4.45 4.5 5.47 HEMBA1006731 1.83 2.95 3.95 4.12 5.51 3.1 HEMBA1006737 1.82 3.5 6.59 3.89 5.09 4.45 HEMBA1006742 1.78 2.44 4.16 3.32 4.14 3.61 HEMBA1006743 4 4.02 11.48 14.16 17.25 11.88 HEMBA1006744 1.84 1.79 7.74 6.6 8.29 5.72 HEMBA1006749 1.14 1.27 3.72 1.88 3.8 1.71 HEMBA1006752 16.53 16.28 26.81 35.31 18.85 33.99 HEMBA1006754 1.44 2.6 3.63 5.55 4.33 2.49 HEMBA1006758 1.38 2.83 4.25 6.89 4.68 4.02 HEMBA1006767 3 4.14 7.88 6.81 7.89 5.51 HEMBA1006770 5.05 2.61 7.12 7.89 8.1 5.05 HEMBA1006779 4.44 4.1 10.99 9.57 10.28 8.42 HEMBA1006780 3.28 3.19 10.27 7.6 8.33 8.38 HEMBA1006789 2.83 1.87 11.34 4.55 5.42 5.51 HEMBA1006795 2.13 2.45 7.58 4.56 7.87 3.29 HEMBA1006796 4.31 3.15 5.37 5.85 7.06 4.72 HEMBA1006805 2.72 2.73 5.9 12.77 17.38 12.96 ** + HEMBA1006807 30.32 28.07 75.38 54.22 54.72 67.82 HEMBA1006813 0.93 1.73 2.81 1.93 4.17 0.97 HEMBA1006819 3.73 4.53 8.5 7.02 8.09 5.29 HEMBA1006821 1.56 2.37 6.09 5.05 4.24 4.36 HEMBA1006824 2.13 3.13 7.39 5.69 6.04 5.75 HEMBA1006832 19.84 18.63 56.97 59.26 61.56 53.28 HEMBA1006834 13.23 12.47 20.38 29.88 28.37 21.62 * + HEMBA1006835 1.11 1.49 3.88 5.08 7.25 4.6 * + HEMBA1006843 19.27 17.89 35.47 55.34 39.67 68.17 * + HEMBA1006849 5.64 4.37 11.23 10.07 11.23 10.83 HEMBA1006850 31.45 33.76 60.2 44.62 53.25 45.59 HEMBA1006861 12.19 11.3 24.61 22.49 16.43 17.99 HEMBA1006865 5.42 8.35 31 33.77 33.36 34.49 HEMBA1006867 4.32 5.03 6.41 6.27 7.76 6.15 HEMBA1006873 3.14 3.59 8.87 6.5 9.26 7.75 HEMBA1006877 2.52 4.03 5.87 4.03 6.26 3.68 HEMBA1006878 2.52 2.36 6.79 3.82 7.86 3.51 HEMBA1006879 6.19 5.68 8.83 11.06 15.86 17.33 * + HEMBA1006884 10.11 3.17 6.59 6.15 8.42 8.78 HEMBA1006885 7.02 6.82 14.16 20.86 19.11 21.73 * + HEMBA1006886 20.38 17.25 26.55 29.45 29.15 40.93 HEMBA1006889 2.61 4.02 4.85 4.48 5.99 6.09 HEMBA1006896 19.11 24.76 31.7 33.67 39.11 40.41 * + HEMBA1006900 6.19 5.93 20.76 16.81 23.73 18.45 HEMBA1006902 1.43 2.45 3.86 4.03 6 3.98 HEMBA1006912 1.24 1.74 6.86 4.12 5.8 5.3 HEMBA1006914 6.64 6.11 18.27 14.81 18.62 15.03 HEMBA1006916 3.11 2.71 5.78 10.29 7.48 9.36 * + HEMBA1006921 3.03 3.5 9.63 9.77 11.26 13.59 HEMBA1006926 2.65 2.61 5.68 5.01 6.53 6.98 HEMBA1006927 3.06 2.2 5.17 3.57 5.26 5.89 HEMBA1006929 2.94 2.69 4.02 4.31 6.36 5.25 * + HEMBA1006936 3.72 3.21 6.51 4.67 6.25 5.45 HEMBA1006938 1.21 2.11 6.57 2.37 3.76 3.44 HEMBA1006941 9.52 8.15 12 19.26 28.62 23.74 ** + HEMBA1006942 5.2 2.63 6.65 10.7 10.65 11.4 ** + HEMBA1006945 10.07 5.91 16.81 23.73 17.09 19.91 HEMBA1006949 1.6 1.43 3.88 2.48 5.34 2.81 HEMBA1006952 1.16 1.66 2.98 3.02 5.04 2.22 HEMBA1006960 2.53 2.78 7.66 5.9 8.28 8.68 HEMBA1006973 1.74 2.27 5.91 4.7 7.84 5.54 HEMBA1006974 2.49 3.44 6.76 6.09 11.01 8.14 HEMBA1006976 1.39 1.5 4.12 3.18 4.96 4.36 HEMBA1006989 1.85 1.66 6.51 2.05 3.01 1.81 HEMBA1006993 2.71 2.39 6.49 6.11 7.69 8.79 HEMBA1006996 0.74 1.15 2.98 2.52 3.13 3.58 HEMBA1007001 1.91 2.47 5.12 3.98 6.37 4.76 HEMBA1007002 7.02 4.12 31.4 26.92 38.45 42.11 HEMBA1007013 1.02 0.94 3.04 1.44 4.39 2.27 HEMBA1007016 2.02 1.43 5.06 3.27 5.97 5.28 HEMBA1007017 0.69 1.24 2.55 1.42 3.33 1.83 HEMBA1007018 4.02 4.52 6.54 7.65 6.1 7.07 HEMBA1007044 8.13 8.41 17.4 15.48 11.97 12.27 HEMBA1007045 1.64 2.15 4.42 2.61 5.08 3.47 HEMBA1007051 2.26 2.56 4.71 3.42 4.42 3.28 HEMBA1007052 2.23 1.25 3.47 2.37 4.62 1.83 HEMBA1007053 1.83 3.14 4.03 2.64 4 2.5 HEMBA1007057 0.92 2.56 3.21 3.52 4.03 3.41 HEMBA1007062 0.91 0.82 2.73 2.34 2.87 1.82 HEMBA1007063 3.87 2.7 8.87 8.56 8.02 7.58 HEMBA1007066 1.72 2.03 3.62 2.2 4.39 2.71 HEMBA1007069 1.36 2.29 3.87 3.84 3.48 3.66 HEMBA1007073 1.93 2.16 6.12 2.96 9.57 3.6 HEMBA1007076 1.48 2.6 5.56 4.66 7.6 3.4 HEMBA1007078 6.5 6.83 18.61 26.96 27.47 23.78 * + HEMBA1007080 7.6 9.46 38.27 61.02 68.15 51.34 * + HEMBA1007084 1.28 1.42 4.76 3.68 6.27 4.76 HEMBA1007085 3.28 2.89 8.21 5.76 7.21 5.42 HEMBA1007087 2.6 2.88 6.31 3.96 6.92 5.63 HEMBA1007089 26.17 28.1 43.8 46.11 34.41 29.42 HEMBA1007095 75.81 62.79 111.43 134.53 48.47 121.4 HEMBA1007101 2.78 3.27 8 26.73 21.52 19.57 ** + HEMBA1007104 1.87 1.92 3.52 2.46 4.53 2.57 HEMBA1007106 4.77 4.8 9.03 16.42 12.5 9.49 HEMBA1007112 3.01 3.07 5.16 6.39 6 4.77 HEMBA1007113 1.53 2.29 9.04 6.03 6.1 5.97 HEMBA1007121 13.76 14 92.08 116.14 111.53 129.12 * + HEMBA1007129 1.54 2.44 2.87 2.66 4.37 1.89 HEMBA1007147 1.68 2.88 4.4 3.96 4.76 4.06 HEMBA1007149 5.3 7.24 8.38 10.48 6.82 9.73 HEMBA1007151 0.85 1.87 3.38 3.32 3.88 2.54 HEMBA1007172 1.26 1.91 4.13 2.96 4.81 3.51 HEMBA1007174 1.4 1.43 2.75 3.96 3.65 2.5 HEMBA1007176 2.58 3.95 11.7 6.7 6.78 4.52 HEMBA1007178 4.77 4.71 9.32 10.94 13.03 8.12 HEMBA1007185 9.38 10.32 9.59 19.5 7.83 15.16 HEMBA1007186 1.71 2.76 4.49 4.95 5.47 3.86 HEMBA1007194 4.81 3.43 5.58 7.83 9.34 8.67 ** + HEMBA1007200 1.18 2.33 2.9 3.25 4.6 1.66 HEMBA1007203 1.54 3.5 5.38 6.03 6.87 5.05 HEMBA1007206 1.92 2.46 5.72 7.07 7.91 5.94 HEMBA1007224 5.4 6.5 9.06 9.23 5.85 8.06 HEMBA1007226 7.19 8.07 40.61 59.31 70.51 62.19 * + HEMBA1007240 10 10.96 13.45 15.35 7.71 11 HEMBA1007241 3.59 2.88 4.56 4.61 6.81 3.63 HEMBA1007242 2.52 2.86 5.01 6.29 6.87 4.23 HEMBA1007243 10.23 10.91 69.57 70.17 95.69 82.75 HEMBA1007251 1.32 1.8 4.14 3.02 3.67 2.01 HEMBA1007256 1.39 1.91 3.36 3.93 5.74 3.44 HEMBA1007267 3.19 3.71 8.75 8.73 9.18 8.1 HEMBA1007273 0.98 2.66 3.84 3.56 5.82 2.25 HEMBA1007279 1.55 2.25 3.52 2.95 4.35 2.02 HEMBA1007281 1.73 1.54 2.12 2.95 4.43 1.01 HEMBA1007283 2.45 3.15 6.78 6.37 6.58 5.96 HEMBA1007288 2.12 2.77 5.54 4.35 6.74 5.48 HEMBA1007291 1.59 1.8 4.29 2.14 4.4 0.98 HEMBA1007299 20.39 22.25 39.67 40.95 47.97 40.26 HEMBA1007300 2.08 2.75 3.59 4.17 4.45 4.07 * + HEMBA1007301 1.97 2.82 3.15 3.73 3.99 3.44 * + HEMBA1007319 2.84 3.61 6.73 5.21 6.12 3.32 HEMBA1007320 1.29 1.22 3.12 4.19 3.45 2.42 HEMBA1007322 19.97 17.81 27.74 45.24 39.42 37.31 ** + HEMBA1007323 4.54 6.69 11.47 6 6.36 6.21 HEMBA1007326 4.58 3.85 13.34 8.29 8.07 9 HEMBA1007327 3.37 3.98 8.91 6.14 9.31 8.98 HEMBA1007332 3.12 3.47 5.42 5.27 7.56 5.33 HEMBA1007341 1.4 2.51 3.24 2.93 3.38 3.36 HEMBA1007342 1.06 2.05 3.02 1.52 3.23 1.98 HEMBA1007347 3.39 3.24 6.34 4.55 7.34 6.32 HEMBA1007353 2.43 2.22 4.99 2.68 6.9 3.01 HEMBB1000005 1.57 2.54 5.35 2.68 4.65 3.64 HEMBB1000008 2.19 2.53 5.99 3.51 6.31 3.71 HEMBB1000018 2.21 2.16 7.13 9.9 9.79 7.24 HEMBB1000024 3.71 2.15 5.4 5.13 5.77 6.39 HEMBB1000025 2.11 2.09 3.55 1.68 5.13 2.62 HEMBB1000030 3.12 3.53 6.58 6.62 7.77 6 HEMBB1000036 5.3 4.76 5.04 6.95 8.19 5.93 * + HEMBB1000037 4.43 3.64 4.73 4.63 8.38 5.32 HEMBB1000039 1.17 0.96 3.98 2.61 4.11 2.95 HEMBB1000044 1.22 2.35 4.26 5.28 5.58 5.36 * + HEMBB1000048 3.2 1.7 3.48 3.99 5.4 3.96 HEMBB1000050 2.32 1.55 3.33 2.97 3.98 2.85 HEMBB1000054 2.03 2.08 7.07 4.49 5.09 3.98 HEMBB1000055 42.59 36.75 92.41 100.33 86.52 89.35 HEMBB1000059 2.5 2.65 11.34 10.96 11.52 14.73 HEMBB1000072 6.84 7.77 58.85 73.22 97.61 76.22 * + HEMBB1000081 2.85 3.56 10.79 5.69 6.19 7.23 HEMBB1000083 1.13 1.95 5.38 4.88 5.89 5.33 HEMBB1000089 1.14 2.53 4.54 6.03 6.73 5.43 * + HEMBB1000094 4.12 4.3 8.4 4.24 5.04 6.62 HEMBB1000097 2.48 1.71 7.91 4.75 4.55 4.3 HEMBB1000099 2.69 2.07 6.27 5.18 6.75 5.64 HEMBB1000103 7.19 5.28 18.55 13.99 19.26 16.16 HEMBB1000106 3.91 3.75 8.15 4.24 6.4 5.9 HEMBB1000113 1.25 1.54 3.33 1.39 4.14 2.31 HEMBB1000119 2.19 2.17 5.66 3.34 6.12 4.05 HEMBB1000133 21.01 22.21 30.57 43.5 66.13 60.69 * + HEMBB1000134 4.92 2.95 8.69 13.39 9.79 9.8 HEMBB1000136 7.14 8.81 29.63 23.11 26.28 28.23 HEMBB1000141 1.98 2.85 6.18 4.95 5.75 6.16 HEMBB1000144 2.05 2.59 4.85 3.09 5.36 1.38 HEMBB1000147 3.77 2.08 4.51 4.55 7.39 3.07 HEMBB1000152 0.79 1.45 3.42 5.13 5.15 3.45 HEMBB1000154 0.98 1.11 3.43 2.59 2.89 2.47 HEMBB1000155 0.88 0.54 3.15 3.33 4.15 1.92 HEMBB1000173 3.35 3.72 12.14 10.1 10.89 7.51 HEMBB1000175 1.85 1.32 3.39 6.06 4.09 3.86 HEMBB1000176 1.48 4.03 6.12 3.43 9.75 5.03 HEMBB1000198 0.88 1.72 3.64 2.6 3.59 3.22 HEMBB1000208 1.12 1.52 3.04 1.74 3.23 2.69 HEMBB1000209 1.62 1.54 3.76 3.32 3.94 3.28 HEMBB1000212 1.88 1.03 3.26 4.37 3.93 1.98 HEMBB1000215 1.61 2.13 3.8 4.67 5.49 5.32 * + HEMBB1000217 5.67 4.97 11.23 15.21 18.81 11.78 * + HEMBB1000218 2.13 2.28 11.05 7.47 10.07 7.05 HEMBB1000226 2.63 3.26 6.02 4.02 5.86 3.41 HEMBB1000230 1.39 1.83 3.73 1.95 4.31 2.58 HEMBB1000240 6.04 8.26 10.01 3.97 2.7 1.75 * - HEMBB1000244 1.39 1.64 3.51 2.51 2.63 1.68 HEMBB1000250 1.17 0.99 1.12 1.94 1.25 1.12 HEMBB1000258 1.71 1.94 5.8 4.38 5.63 3.27 HEMBB1000264 2.49 3.12 11.01 8.64 8.34 8.1 HEMBB1000266 2.81 2.65 5.52 3.38 5.95 3.71 HEMBB1000272 4.76 4.16 6.06 8.38 6.88 7.45 * + HEMBB1000274 1.51 1.15 3.17 2.54 3.18 1.88 HEMBB1000276 1.12 1.84 4.72 3.1 4.01 2.43 HEMBB1000284 0.94 1.81 2.89 2.83 3.11 1.65 HEMBB1000307 1.52 1.7 4.78 2.8 5.31 3.27 HEMBB1000309 1.43 2.73 3.07 3.09 3.56 2.19 HEMBB1000312 1.99 1.38 5.18 7.03 7.2 4.35 HEMBB1000317 0.17 1.62 3.32 2.6 4.73 2.14 HEMBB1000318 1.11 2.69 3.85 2.28 4.46 1.68 HEMBB1000332 3.12 3.84 4.37 3.75 3.95 2.72 HEMBB1000335 0.77 2.35 4.66 6.16 4.66 3.44 HEMBB1000336 0.99 1.11 3.59 2.09 3.52 2.29 HEMBB1000337 4.3 5.06 20.22 22.86 24.84 22.82 HEMBB1000338 2.11 1.92 5.86 7.13 8.92 4.71 HEMBB1000339 1.66 1.76 5.84 3.75 4.99 3.84 HEMBB1000341 1.4 1.91 3.68 3.06 4.77 2.83 HEMBB1000343 2.51 3.15 6.96 7.24 8.68 7.46 HEMBB1000354 3.26 3.5 10.36 7 8.93 8.07 HEMBB1000358 1.09 2.11 3.82 3.43 2.83 1.93 HEMBB1000369 1.93 2.33 3.87 5.96 6.54 2.89 HEMBB1000373 1.77 2.73 3.91 2.26 6.2 2.94 HEMBB1000374 3.27 4.06 9.34 9.58 13.36 6.95 HEMBB1000376 2.71 3.92 12.28 10.03 6.99 7.71 HEMBB1000383 60.87 62.14 104.01 69.28 57.52 83.25 HEMBB1000391 1.8 2.66 4.57 4.89 6.18 4.29 HEMBB1000399 2.51 3.79 3.69 3.93 5.72 3.71 HEMBB1000402 1.61 2.06 3.33 2.67 5.3 1.72 HEMBB1000404 1.34 1.15 5.18 2.56 5.29 1.81 HEMBB1000407 2.2 3.36 6.76 5.57 5.75 4.66 HEMBB1000420 1.93 1.46 3.86 4.33 4.76 4.54 * + HEMBB1000430 38.77 36.24 61.06 51.76 34.69 50.02 HEMBB1000434 3.05 4.73 9.02 6.54 6.59 6.63 HEMBB1000438 1.13 1.83 4.16 2.23 4 1.39 HEMBB1000441 2.26 3 7.35 5.44 8 4.78 HEMBB1000447 29.84 32.01 39.91 35.88 44.02 33.55 HEMBB1000449 1.3 1.31 3.72 1.51 3.04 1.54 HEMBB1000453 8.61 8.04 13.39 14.23 18.78 13.74 HEMBB1000455 1.29 1.97 3.19 3.13 5.46 3.54 HEMBB1000472 2.3 2.28 4.22 4.07 4.35 3.52 HEMBB1000480 1.9 3.59 7.03 5.71 6.63 5.87 HEMBB1000486 2.15 2.98 6.93 4.82 7.86 5.9 HEMBB1000487 1.21 1.79 4.48 2.66 4.8 2.57 HEMBB1000490 3.67 4.13 12.61 7.92 8.7 6.55 HEMBB1000491 1.36 2.91 5 3.83 4.78 4.42 HEMBB1000492 3.02 4.04 6.84 5.63 6.94 5.34 HEMBB1000493 1.57 1.71 3.26 2.41 5.38 3.27 HEMBB1000510 1.32 1.71 4.94 4.4 5.61 4.21 HEMBB1000516 5.64 7.71 36.22 16.62 18.58 17.09 HEMBB1000518 0.88 1.22 2.63 2.21 4.27 1.73 HEMBB1000523 1.32 2.78 7.41 3.33 7.74 4.1 HEMBB1000530 2.83 2.51 9.72 6.06 7.81 6.64 HEMBB1000542 3.08 4.55 9.39 8.48 14.07 9.82 HEMBB1000550 4.84 2.87 4.77 10.48 5.74 5.33 HEMBB1000554 2.14 2.26 8.65 6.43 11.59 7.19 HEMBB1000556 2.64 2.68 4.48 3.1 4.67 4.6 HEMBB1000564 1.81 1.4 5.87 4.26 5.34 6.18 HEMBB1000567 1.39 1.71 3.7 2.1 3.87 3.3 HEMBB1000569 3.78 2.72 8.76 4.88 7.13 5.65 HEMBB1000573 3.48 3.44 11.31 7.33 9.55 7.56 HEMBB1000575 12.42 2.7 10.57 7.16 8.38 12.35 HEMBB1000579 2.12 3.75 4.84 3.01 8.61 4.04 HEMBB1000585 0.83 1.19 3.19 2 4.1 3.35 HEMBB1000586 2.18 1.41 4.28 4.07 4.23 4.11 HEMBB1000589 2.98 1.58 3.62 3.38 3.75 3.69 HEMBB1000591 2.62 2.15 3.96 4.44 5.26 4.64 * + HEMBB1000592 2.05 1.2 3.18 3.87 3.39 2.15 HEMBB1000593 10.25 5.67 51.69 53.87 82.75 77.88 * + HEMBB1000595 6.42 5.2 11.24 12.51 17.1 9.55 HEMBB1000598 1.57 1.69 5.91 2.94 6.76 4.77 HEMBB1000611 0.94 1.16 2.08 1.15 2.79 1.66 HEMBB1000617 2.01 3.04 9.31 6.14 8.79 6.97 HEMBB1000623 2.51 3.08 4.64 5.58 5.83 3.9 HEMBB1000630 3.23 2.5 3.78 2.42 5.54 2.51 HEMBB1000631 8.91 10.69 18.75 22.52 23.76 22.55 * + HEMBB1000632 6.77 8.77 20.85 27.2 18.4 23.31 HEMBB1000636 9.52 15.91 22.42 25.26 21.65 19.96 HEMBB1000637 6.63 9.77 19.44 17.77 24.39 20.28 HEMBB1000638 1.44 1.41 3.23 3.6 5.29 3.34 HEMBB1000642 3.47 2.31 7.58 7.65 9.33 9.93 HEMBB1000643 0.71 1.87 2.71 1.62 3.54 2.12 HEMBB1000649 2.25 2.22 6.45 4.94 7.61 5.72 HEMBB1000652 1.8 2.21 5.33 5.13 5.14 4.93 HEMBB1000655 1.07 1.17 3.24 1.64 4.74 2.01 HEMBB1000665 0.52 1.08 2.23 1.69 2.92 2.01 HEMBB1000668 1.85 1.46 2.76 5.07 5.42 4.1 ** + HEMBB1000671 2.36 2.01 6.77 7.03 7.81 6.94 HEMBB1000673 0.75 1.27 2.92 2.84 4.63 2.43 HEMBB1000679 3.26 2.84 5.59 4.42 7.19 5.76 HEMBB1000684 1.83 2.53 6.6 5.01 6.92 5.6 HEMBB1000692 0.93 2 2.46 1.77 2.5 1.09 HEMBB1000693 0.96 1.29 2.47 1.6 2.79 1.34 HEMBB1000705 2.61 2.52 4.85 4.97 8.2 6.53 HEMBB1000706 0.78 1.07 2.18 2.56 2.93 1.06 HEMBB1000709 3.53 2.92 8.39 8.16 7.99 10.26 HEMBB1000714 1.41 2.85 9.32 5.31 10.37 8.79 HEMBB1000725 1.61 2.22 4.35 3.04 6.22 4.72 HEMBB1000726 1.88 2.34 8.76 5.63 7.1 4.83 HEMBB1000729 1.82 3.28 4.3 3.3 5.21 2.79 HEMBB1000738 1.94 2.6 5.55 3.99 5.53 6.15 HEMBB1000749 4.06 4.15 7.47 7.48 9.56 8.27 HEMBB1000763 5.81 5.56 6.21 6.65 9.9 6.61 HEMBB1000770 2.76 2.06 8.8 7.73 9.62 8.83 HEMBB1000774 1.62 2.75 3.7 3.07 4.39 2.34 HEMBB1000777 5.17 5.49 7.42 6.86 4.9 7.37 HEMBB1000781 3.7 4.19 6.89 7.64 5.28 6.83 HEMBB1000788 0.87 1.79 2.45 2.65 4.88 1.35 HEMBB1000789 1.91 2.22 3.01 3.1 6.55 1.86 HEMBB1000790 1.97 2.15 4.48 4.59 4.21 2.53 HEMBB1000794 1.46 1.8 2.85 2.97 3.84 2.06 HEMBB1000807 2.55 2.72 5.18 3.57 4 4.26 HEMBB1000809 30.31 26.87 132.99 158.22 156.74 195.14 * + HEMBB1000810 1.98 2.67 4.51 3.76 6.08 4.12 HEMBB1000821 1.98 1.93 2.98 2.05 4.45 1.79 HEMBB1000822 1.08 1.97 2.31 1.65 5.31 1.46 HEMBB1000826 1.36 1.99 3.57 3.77 6.11 3.6 HEMBB1000827 2.48 2.89 5.83 2.67 5.05 2.99 HEMBB1000831 3.4 2.31 5.67 3.84 7.74 2.95 HEMBB1000835 1.76 1.94 6.2 7.59 7.62 7.47 * + HEMBB1000840 1.27 2.95 6.89 4.48 7.19 3.01 HEMBB1000848 2.08 3.45 5.63 5.39 6.45 5.3 HEMBB1000852 1.26 2.16 2.8 1.07 4.51 1.55 HEMBB1000857 7.65 6.49 8.13 7.01 10.69 11.53 HEMBB1000858 3.7 3.13 7.3 7.07 9.38 7.31 HEMBB1000867 2.21 1.84 4.9 3.02 5.55 4.04 HEMBB1000870 1.64 2.37 4.56 2.84 5.31 3.63 HEMBB1000876 1.48 2.86 3.91 4.54 3.22 3.93 HEMBB1000881 3.35 5.56 10.5 6.12 5.88 3.85 HEMBB1000883 1.02 2.68 2.2 3.03 3.32 2.58 HEMBB1000887 16.9 14.54 43.41 67.39 61.26 59.84 * + HEMBB1000888 1.03 1.67 2.39 1.63 3.92 1.86 HEMBB1000890 2.93 3.36 10.85 6.01 8.62 7.68 HEMBB1000893 3.28 2.54 5.46 4.5 6.14 5.57 HEMBB1000900 1.27 1.53 2.98 2.06 2.54 1.58 HEMBB1000905 5.09 3.75 6.6 10.05 9.45 8.77 ** + HEMBB1000908 3.34 2.79 3.01 4.48 4.71 5.7 ** + HEMBB1000910 1.74 2.91 2.55 2.09 3.56 2.24 HEMBB1000913 1.41 1.51 2.22 2.8 3.41 1.91 HEMBB1000915 32.08 25.6 50.05 48 58.92 51.07 HEMBB1000917 2.1 2.78 5.72 2.99 4.52 3.44 HEMBB1000927 1.45 1.24 1.82 1.49 3.25 1.88 HEMBB1000932 0.66 2.06 2.74 1.81 3.41 1.61 HEMBB1000933 7.47 7.12 10.71 12.88 12.78 19.19 HEMBB1000936 1.44 1.96 2.87 3.75 6.44 3.55 HEMBB1000939 7.86 7.14 9.02 15.98 15.3 18.25 ** + HEMBB1000941 1.53 1.86 3.17 3.99 4.46 3.52 * + HEMBB1000947 3.53 3.34 4.61 4.67 6.8 5.72 HEMBB1000954 1.08 1.82 2.54 1.62 4.01 3.08 HEMBB1000959 0.77 1.41 3.11 2.23 4.42 1.87 HEMBB1000973 1.21 1.12 2.6 2.07 4.47 3.2 HEMBB1000975 0.9 1.28 1.55 2.48 2.86 1.7 * + HEMBB1000981 1.54 0.66 1.99 1.84 3.47 2.03 HEMBB1000985 1.67 1.82 2.71 3.59 3.99 3.24 * + HEMBB1000991 0.99 1.35 2.83 1.46 3.75 2.43 HEMBB1000996 4.89 3.12 6.78 6.75 6.64 11.18 HEMBB1001000 1.86 1.39 4.06 3.07 5.46 3.88 HEMBB1001004 1.15 1.32 2.57 2.56 4.55 2.42 HEMBB1001008 1.48 1.79 2.75 2.44 4.6 2.88 HEMBB1001011 1.34 1.15 1.53 2.47 2.24 2.9 ** + HEMBB1001014 1.31 1.43 2.3 2.73 4.84 4.1 * + HEMBB1001020 1.17 0.75 2.77 1.77 2.67 2.26 HEMBB1001024 3.31 1.72 6.27 5.47 7.56 6.82 HEMBB1001026 5.14 4.03 5.16 5.46 7.67 5.44 HEMBB1001037 2 1.45 4.73 3.52 5.69 6.67 HEMBB1001042 0.52 1.15 2.69 1.29 3.61 0.87 HEMBB1001046 1.18 1.28 2.16 1.67 3.82 0.96 HEMBB1001047 1.01 1.7 3.79 2.2 3.83 3.83 HEMBB1001048 2.5 2.34 7.02 4.34 11.02 6.93 HEMBB1001051 1.44 2.62 3.23 3.95 6.26 3.9 HEMBB1001056 1.61 2.67 4.89 3.75 5.7 3.78 HEMBB1001058 1.3 1.92 4.72 2.64 6.92 2.63 HEMBB1001060 0.69 0.68 1.75 2.05 4.61 1.85 HEMBB1001063 1.23 1.83 3.52 2.43 4.21 2.9 HEMBB1001068 1.84 3.62 3.59 3.46 7.14 5.2 HEMBB1001082 2.24 2.57 5.98 5.38 6.93 6.36 HEMBB1001095 6.39 7.45 11.76 14.04 14.61 13.16 * + HEMBB1001096 1.3 1.91 3.05 3.21 4.12 3.49 HEMBB1001101 7.41 8.19 9.74 19.33 13.1 16.69 * + HEMBB1001102 1.04 1.47 4.57 3.6 6.07 4.46 HEMBB1001104 1.66 1.89 3.98 3.1 4.87 4.25 HEMBB1001105 1.57 1.59 2.13 3.11 4.82 2.71 HEMBB1001112 9.44 8.91 73.3 100.88 136.14 131.28 * + HEMBB1001113 2.11 1.94 9.1 5.65 8.02 6.81 HEMBB1001114 1.88 2.27 5.18 4.16 7.06 4.82 HEMBB1001115 5.78 7.88 14.52 16.77 9.5 14.78 HEMBB1001117 1.7 1.52 2.92 1.85 2.79 1.79 HEMBB1001119 1.69 1.57 4 2.29 3.74 2.28 HEMBB1001126 1.85 1.88 3.63 2.69 4.96 2.9 HEMBB1001133 3.15 2.42 4.24 6.56 6.15 6.44 ** + HEMBB1001137 1.97 2.2 4.4 3.28 6.56 5.42 HEMBB1001142 2.96 2.68 10.51 9.2 11.69 10.38 HEMBB1001145 3.25 3.56 7.39 6.11 7.7 6.59 HEMBB1001151 5.67 6.58 9.21 12.85 7.67 7.84 HEMBB1001153 2 1.89 4.57 3.79 5.37 2.9 HEMBB1001158 6.96 6.74 12.17 12.04 9.95 11.16 HEMBB1001169 1.71 2.45 4.42 2.89 4.21 2.86 HEMBB1001170 1 1.85 3.27 1.26 2.5 1.61 HEMBB1001175 1.43 1.54 5.16 3.39 6.36 4.14 HEMBB1001177 3.63 2.4 7.54 5.8 6.94 6.69 HEMBB1001182 2.6 3.69 4.89 3.89 6.54 3.87 HEMBB1001192 3.3 3.09 16.1 15.27 20.06 15.75 HEMBB1001199 1.16 2.27 1.91 1.43 3.96 1.15 HEMBB1001200 1.86 1.66 3.14 2.43 5.38 2.29 HEMBB1001208 2.02 2.04 4.56 2.96 6.19 2.74 HEMBB1001209 2.98 2.28 5.75 5.22 6.56 4.92 HEMBB1001210 5.14 4.28 7.8 11.05 6.08 10.33 HEMBB1001215 9.57 10.46 17.69 17.91 15.75 16.96 HEMBB1001217 1.78 2.13 4.39 2.04 3.69 1.89 HEMBB1001218 4.28 3.37 5.47 4.52 5.98 4.6 HEMBB1001221 1.72 1.65 2.75 1.54 4.29 1.34 HEMBB1001224 2.2 2.46 3.81 2.98 6.08 3.7 HEMBB1001230 1.51 2.09 4.36 2.55 4.95 2.22 HEMBB1001234 5.24 6.05 29.26 31 44.04 30.75 HEMBB1001235 12.72 10.54 21.49 13.27 8.47 10.71 HEMBB1001237 11 10.54 21.03 32.1 26.16 36.86 * + HEMBB1001242 4.82 5.68 8.63 6.92 6.97 4.51 HEMBB1001244 1.08 1.1 3.9 1.47 4.36 1.36 HEMBB1001249 1.26 1.63 2.99 1.84 5.52 1.98 HEMBB1001253 1.53 1.92 5.68 1.96 4.89 2.39 HEMBB1001254 1.27 1.19 3.73 1.22 5.09 2.45 HEMBB1001266 2 4.32 4.75 4.49 6.09 4.63 HEMBB1001267 3.51 2.92 9.98 8.43 7.63 8.01 HEMBB1001271 2.25 2.93 3.89 2.59 5.85 3.91 HEMBB1001282 2.27 2.68 3.9 2.77 4.86 2.99 HEMBB1001287 54.06 45.71 83.21 72.79 57.33 77.51 HEMBB1001288 2.45 2.58 3.64 4.57 6.08 3.31 HEMBB1001289 4.64 5.82 12.2 6.93 9.11 6.88 HEMBB1001290 2.82 1.27 4.55 2.89 4.14 1.96 HEMBB1001294 1.03 1.91 3.2 2.93 3.95 2.51 HEMBB1001299 7.06 7.64 12.49 16.26 14.41 17.87 * + HEMBB1001302 2.16 2.34 2.41 1.75 3.39 1.64 HEMBB1001304 1.73 1.34 2.6 1.81 5.2 1.67 HEMBB1001314 1.16 1.07 2.47 1.3 3.63 1.25 HEMBB1001315 1.25 1.62 1.46 0.87 4 0.9 HEMBB1001317 2.1 3.38 6.51 4.12 8.01 4.41 HEMBB1001326 0.88 1.54 2.36 1.51 3 1.69 HEMBB1001331 2.11 2.79 2.81 3.78 6.14 4.55 * + HEMBB1001335 1.39 0.9 1.44 1.4 2.81 1.92 HEMBB1001337 1.86 1.7 3.15 3.34 4.72 4.51 * + HEMBB1001339 4.17 3.87 5.91 5.83 7.91 5.25 HEMBB1001344 1.27 1.36 2.25 1.62 3.44 1.29 HEMBB1001346 2.17 2.32 7.45 5.89 6.23 5.7 HEMBB1001348 0.68 1.37 4.05 1.38 3.68 2.82 HEMBB1001350 2.06 2.09 4.17 2.07 7.74 2.57 HEMBB1001356 1.4 1.9 2.33 1.74 5.54 2.29 HEMBB1001364 0.53 1.28 1.25 1.49 2.47 1.43 HEMBB1001366 1.61 1.71 3.46 4.17 4.27 3.82 * + HEMBB1001367 1.11 2.19 3.79 5.05 6.25 5.75 * + HEMBB1001369 0.56 1.29 2.54 1.95 3.39 2.82 HEMBB1001380 3.13 3.56 6.65 5.43 7.36 7.75 HEMBB1001381 8.45 6.07 9.53 10.2 14.39 11.86 HEMBB1001384 3.48 4.92 5.66 9.52 13.27 11.91 ** + HEMBB1001387 1.19 1.57 3.1 2.36 4.34 1.33 HEMBB1001394 1.53 1.3 1.68 2.7 2.82 1.89 * + HEMBB1001407 0.68 0.83 0.99 0.62 1.33 0.97 HEMBB1001410 1.35 1.04 1.78 2.44 2.63 1.74 HEMBB1001413 1.68 1.84 3.32 3.48 3.27 4.04 HEMBB1001419 2.56 2.24 4.42 3.61 5.47 4.6 HEMBB1001421 2.29 1.66 2.18 1.31 3.16 0.95 HEMBB1001424 0.51 1.2 1.67 -0.1 1.58 0.41 HEMBB1001426 2.04 1.51 3.7 2.66 5.67 4.21 HEMBB1001429 7.11 5.76 9.83 22.69 19.97 19.53 ** + HEMBB1001436 3.13 2.51 6.8 7.5 6.44 7.24 HEMBB1001443 5.61 6.48 20.67 20.46 27.07 22.15 HEMBB1001449 2.02 2 4.92 4.26 6.35 4.27 HEMBB1001454 1.2 1.96 3.77 3.74 5.13 2.99 HEMBB1001458 4.72 6.48 12.41 7.88 9.04 6.89 HEMBB1001461 0.55 1.38 2.01 2.11 2.65 1.07 HEMBB1001463 2.28 2.1 3.7 3.95 5.03 4.66 * + HEMBB1001464 1.73 1.29 3.62 2.66 3.92 2.27 HEMBB1001466 1.15 1.84 2.75 1.88 3.77 2.73 HEMBB1001482 1.76 2.21 4.36 2.94 5.36 3.97 HEMBB1001500 1.01 1.08 1.77 1.96 4.39 1.97 HEMBB1001505 3 3.32 5.87 9.35 14.06 11.17 * + HEMBB1001521 2.06 2.43 5.4 5.15 5.78 7.14 HEMBB1001527 2.63 4.74 11.16 8.69 9.66 9.6 HEMBB1001530 4.15 3.51 6.57 9.43 12.39 7.05 HEMBB1001531 1.11 1.34 4.62 2.99 5.16 4.17 HEMBB1001532 0.63 1.86 2.77 1.86 4.41 2.15 HEMBB1001535 1.99 2.01 4.22 3.34 4.32 5.75 HEMBB1001536 2.18 2.65 6.37 4.62 6.87 5.45 HEMBB1001537 1.31 2.24 3.7 3.21 6.12 2.75 HEMBB1001542 4.39 4.72 6.28 5.26 7.83 5.7 HEMBB1001543 7.84 3.58 8.49 8.13 7.08 5.38 HEMBB1001547 2.02 2.25 2.65 4.2 4.27 2.79 * + HEMBB1001548 2.53 2.62 11.82 17.73 29.92 23.34 * + HEMBB1001551 0.89 1.7 4.47 2.93 5.96 2.65 HEMBB1001555 2.13 2.79 4.78 3.73 5.8 4.64 HEMBB1001562 1.9 2.64 4.27 2.23 3.46 3 HEMBB1001564 132.08 140.08 310.28 333.18 233.12 279.03 HEMBB1001565 1.72 1.97 3.9 3.77 4.68 2.07 HEMBB1001569 0.79 0.8 3.04 2.49 3.68 1.44 HEMBB1001573 1.9 1.04 3.58 4.18 5.53 4.12 * + HEMBB1001585 1.5 1.96 10.91 3.75 7.14 4.87 HEMBB1001586 1.53 2.27 3.22 4.27 5.45 1.95 HEMBB1001588 1.33 2.9 5.74 4.72 6.32 5.06 HEMBB1001595 2.68 3.33 6.92 3.78 4.84 4.7 HEMBB1001596 3.4 2.57 3.74 2.67 5.36 2.54 HEMBB1001599 1.45 1.57 3.21 3.07 3.47 2.06 HEMBB1001603 1.99 2.45 4.17 5.7 8.16 4.04 HEMBB1001606 1.35 2.28 2.42 2 2.39 1.53 HEMBB1001612 4.31 3.07 9.25 8.81 8.09 8.9 HEMBB1001618 1.53 1.62 3.86 2.84 4.48 2.31 HEMBB1001619 2.11 3.03 3.92 5.71 5.1 4.37 * + HEMBB1001623 2.21 2.38 3.16 2.16 5.5 3.37 HEMBB1001625 3.73 3.04 4.33 2.93 4.81 3.79 HEMBB1001630 1.31 2.36 3.54 1.84 4.3 1.23 HEMBB1001635 1.78 1.64 3.76 2.08 3.32 1.34 HEMBB1001637 1.76 1.14 3.98 2.09 4.4 3.58 HEMBB1001641 1.43 1.68 2.78 3.17 3.73 2 HEMBB1001653 2.18 3.17 5.61 3.96 6.63 3.5 HEMBB1001665 1.08 2.17 2.04 2.5 4.43 0.88 HEMBB1001666 2.14 1.95 3.52 2.45 4.88 1.79 HEMBB1001667 2.37 2.25 3.26 2.94 5.13 3.17 HEMBB1001668 3.19 2.11 5.15 2.45 6.42 2.69 HEMBB1001669 0.98 2.02 3.19 1.04 4.53 1.38 HEMBB1001670 4.02 4.82 6.88 10.7 9.71 8.65 * + HEMBB1001673 1.48 2.97 3.61 3.51 4.52 4.43 HEMBB1001675 1.83 3.27 4.65 4.68 5.78 4.88 HEMBB1001679 2.52 2.34 5.06 2.19 3.87 1.88 HEMBB1001684 2.13 1.55 3.89 5.17 6.77 5.05 * + HEMBB1001685 3.41 1.61 4.43 2.91 6.24 2.49 HEMBB1001695 1.9 2.22 4.43 1.38 3.88 2.12 HEMBB1001703 1.25 2.3 5.74 3.58 3.79 4.1 HEMBB1001704 1.39 2.16 4.58 4.23 5.02 3.94 HEMBB1001706 2.76 2.6 3.58 5.6 6.26 4.87 ** + HEMBB1001707 1.35 2.01 2.87 2.25 3.67 2.8 HEMBB1001717 1.68 2.21 3.23 2.61 3.34 2.83 HEMBB1001731 13.81 13.48 24.03 11.02 23.09 25 HEMBB1001734 3.47 3.35 7.62 6.88 9.22 4.18 HEMBB1001735 1.35 1.4 3.4 1.58 3.52 2.03 HEMBB1001736 5.01 6.14 7.87 7.15 10.91 8.11 HEMBB1001747 0.92 1 3.23 1.87 3.67 2.82 HEMBB1001749 4.71 2.99 9.39 7.29 5.99 8.16 HEMBB1001753 3.79 3.3 5.5 7.4 8.97 9.3 ** + HEMBB1001756 0.53 2.05 1.89 2.31 3.91 2.73 HEMBB1001757 1.08 1.8 2.64 3.04 4.86 4.54 * + HEMBB1001760 1.32 0.98 3.74 1.49 3.56 2.13 HEMBB1001762 0.9 0.61 2.62 1.57 2.95 2.07 HEMBB1001780 9.82 12.28 11.34 16.64 26.06 22.06 * + HEMBB1001785 0.89 1.24 1.02 0.62 2.88 1.64 HEMBB1001788 3.22 1.26 5.17 5.76 6.13 5.3 HEMBB1001793 5.6 4.73 18.12 22.08 20.38 22.86 * + HEMBB1001797 1.61 1.82 2.28 2.94 4.97 5.54 * + HEMBB1001802 13.28 9.91 67.77 85.35 82.8 81.27 * + HEMBB1001812 2.32 2.58 6.49 7.68 8.28 9.74 * + HEMBB1001815 128.22 114.78 102.97 87.37 89.21 62.14 * - HEMBB1001816 1.95 2.19 3.97 3.73 6.31 5.73 HEMBB1001831 0.69 0.98 1.54 0.72 3.28 1.16 HEMBB1001834 16.15 9.68 133.91 102.49 173.48 141.04 HEMBB1001836 4.07 1.99 11.4 5.89 6.97 6.7 HEMBB1001839 0.89 0.86 1.43 1.08 1.95 1.21 HEMBB1001841 80.32 59.68 120.73 35.74 39.04 23.13 * - HEMBB1001844 5.26 4.72 9.73 10.15 10.68 8.11 HEMBB1001847 6.93 4.24 8.6 9.06 14.77 10.3 HEMBB1001848 25.33 21.68 40.92 49.73 73.94 62.17 * + HEMBB1001850 3.07 2.93 5.25 3.75 7.19 3.95 HEMBB1001859 13.4 8.82 20.85 39.61 27.01 40.75 * + HEMBB1001863 1.7 3.65 7.66 6.89 8.88 7.5 HEMBB1001867 1.69 1.93 3.16 3.16 4.14 3 HEMBB1001868 2.15 1.53 2.56 1.31 3.57 1.28 HEMBB1001869 1.5 2.3 4.23 4.62 8.15 3.58 HEMBB1001872 1.21 0.79 2.23 1.77 4.17 1.75 HEMBB1001874 1.92 1.2 2.07 2.58 2.47 3.03 * + HEMBB1001875 0.83 1.96 1.7 2.05 3.53 1.37 HEMBB1001880 2.68 2.17 6.79 4.41 8.91 8.35 HEMBB1001899 0.6 1.62 2.15 2.26 4.68 1.91 HEMBB1001903 5.56 5.68 9.61 6.06 6.65 6.7 HEMBB1001905 2.04 2.82 5.49 4.98 6.07 7.14 HEMBB1001906 0.67 1.65 2.64 2.22 5.14 2.62 HEMBB1001908 1.82 1.63 5.26 3.31 6.56 3.59 HEMBB1001910 1.92 1.16 2.64 3.2 4.41 4.61 * + HEMBB1001911 2.06 1.11 4.2 5.73 4.81 4.33 HEMBB1001915 2.53 3.01 5.61 7.13 7.84 9.4 * + HEMBB1001921 2.19 2.21 7.12 6.56 8.47 8.25 HEMBB1001922 1.74 1.77 3.66 4.91 5.85 3.7 HEMBB1001925 1.48 2.24 4.57 3.07 4.73 3.39 HEMBB1001930 0.46 0.94 1.67 0.91 3.18 1.01 HEMBB1001944 1.72 1.88 5.45 4.83 4.6 4.49 HEMBB1001945 2.15 1.05 3.58 2.25 3.97 2.12 HEMBB1001947 2.28 1.13 3.23 5.35 5.98 3.15 HEMBB1001950 3.49 1.95 5.38 5.15 5.46 3.3 HEMBB1001952 1.41 2.05 4.72 2.31 4.73 3.1 HEMBB1001953 1.62 2.09 3.45 3.63 5.78 3.75 HEMBB1001957 1.16 2.02 4.28 2.68 4.19 2.19 HEMBB1001959 2.05 3.31 4.07 4.22 5.75 3.68 HEMBB1001962 5.54 2.61 5.11 3.34 6.28 2.54 HEMBB1001967 2.59 2.46 5.62 6.11 8.49 6.15 HEMBB1001973 2.25 2.4 6.14 7.62 10 7.28 * + HEMBB1001978 2.08 1.71 6.29 7.2 7.57 5.83 HEMBB1001983 9.23 8.69 24.64 38.93 34.91 36.79 * + HEMBB1001987 1.78 2.34 3.64 1.66 4.75 2.38 HEMBB1001988 2.02 1.92 3.42 2.92 5.17 1.85 HEMBB1001990 7.65 7.72 9.18 12.44 11.53 15.42 * + HEMBB1001996 1.54 1.47 3.89 1.61 3.51 1.22 HEMBB1001997 1.46 2.25 6.1 4.2 5.98 4.23 HEMBB1001999 10.91 11.08 16.84 24.47 26.58 22.28 ** + HEMBB1002002 1.08 1.58 3.52 1.91 2.76 2.39 HEMBB1002005 1.88 2.91 4.8 4.82 7.6 4.22 HEMBB1002009 2.32 2.48 3.03 2.24 6.23 2.7 HEMBB1002013 0.96 2.07 3.78 1.95 4.26 1.41 HEMBB1002015 3.95 4.25 9.47 5.82 8.92 6.73 HEMBB1002024 45.16 34.47 111.32 113.31 106.76 120.55 HEMBB1002035 2.15 1.91 2.87 2.11 4.5 2.68 HEMBB1002039 1.18 2.29 5.1 3.28 5.9 2.98 HEMBB1002041 3.31 4.13 8.49 15.49 14.42 13.38 ** + HEMBB1002042 3.97 4.66 9.49 8.09 10.63 9.94 HEMBB1002043 1.34 2.21 4.61 5.97 5.24 3.36 HEMBB1002044 0.4 1.19 2.68 1.25 4.19 1.92 HEMBB1002045 2.83 2.5 10.03 6.34 7.63 4.56 HEMBB1002049 1.31 1.4 3.77 1.71 4.36 1.73 HEMBB1002050 1.62 1.61 4.5 3.31 4.53 2.94 HEMBB1002051 1.17 1.13 2.9 2.59 5.05 4.37 HEMBB1002068 1.69 2.44 2.43 2.3 4.42 2.07 HEMBB1002069 3.39 3.94 7.83 6.86 7.55 5 HEMBB1002075 0.72 1.94 3.33 2.99 3.52 2.37 HEMBB1002079 1.2 1.8 1.89 1.22 2.84 1.3 HEMBB1002080 1.74 1.85 4.78 1.55 6.02 2.41 HEMBB1002082 1.03 1.85 4.59 2.38 4.38 1.96 HEMBB1002084 25.86 22.68 51.44 33.52 35.54 38.37 HEMBB1002088 13.92 15.78 22.14 29.46 37.25 35.66 ** + HEMBB1002092 2.51 2.24 4.48 5.34 3.65 6.27 HEMBB1002094 3.21 2.62 8.2 5.72 7.27 6.04 HEMBB1002103 2.42 2.97 3.51 3.74 5.58 4.47 HEMBB1002109 4.27 3.47 4.84 5.72 7.83 6.36 * + HEMBB1002115 42.37 37.4 91.88 95.86 101.94 101.65 HEMBB1002120 0.89 1.22 2.91 0.86 2.94 2.41 HEMBB1002121 0.75 1.56 1.63 1.5 4.66 2.53 HEMBB1002134 11.99 11.22 112.59 98.93 166.1 133.77 HEMBB1002136 1.29 1.65 2.9 2.59 3.26 2.58 HEMBB1002138 10.48 9.64 20.72 18.78 23.06 19.4 HEMBB1002139 1.84 1.6 5.46 4.69 6 5.84 HEMBB1002141 1.53 0.83 3.44 1.48 4.64 2.54 HEMBB1002142 1.85 2 4.95 3.22 5.98 6.03 HEMBB1002145 1.62 0.83 2.96 1.49 3.07 2.42 HEMBB1002152 1.27 1.19 3.15 2.32 6.36 3.41 HEMBB1002162 1.25 1.55 3.92 3.42 5.14 3.61 HEMBB1002173 4.18 1.09 5.58 2.77 4.48 3.84 HEMBB1002189 2.78 1.95 6.14 7.01 8.25 5.93 HEMBB1002190 1.81 2.2 6.36 8.01 6.93 8.36 * + HEMBB1002193 1.84 1.06 2.06 4.53 4.37 5.48 ** + HEMBB1002217 3.82 2.26 6.02 3.61 6.06 3.23 HEMBB1002218 3.91 3.3 7.58 4.94 6.15 5.68 HEMBB1002228 2.28 2.9 6.17 6.68 7.94 6.97 HEMBB1002232 1.15 1.4 2.24 2.14 5.79 3.03 HEMBB1002245 0.86 0.84 2.34 1.53 2.47 1.05 HEMBB1002247 1.72 0.59 2.44 1.38 2.24 1.03 HEMBB1002249 2.65 1.64 3.1 3.39 4.08 4.01 * + HEMBB1002254 1.35 1.35 3.83 2.64 3.27 2.86 HEMBB1002255 0.99 1.37 2.6 1.19 2.93 1.4 HEMBB1002266 1.33 0.83 2.07 0.73 1.99 0.54 HEMBB1002271 14.89 9.5 29.42 32.9 41.53 37.28 * + HEMBB1002280 1.62 0.78 1.6 1.55 2.93 1.12 HEMBB1002296 11.83 12.31 18.29 31.87 21.06 23.09 * + HEMBB1002300 0.78 2.31 3.48 1.49 4.63 3.12 HEMBB1002302 1.17 2.17 3.26 2.49 4.76 3.04 HEMBB1002306 1.83 1.96 4.28 2.91 4.34 2.6 HEMBB1002316 0.66 1.38 2.36 1.19 2.9 0.97 HEMBB1002326 0.93 1.68 4.52 4.35 4.41 3.9 HEMBB1002327 0.99 0.99 2.66 1.46 2.95 2.06 HEMBB1002329 2.89 3 3.81 6.39 5.88 5.53 ** + HEMBB1002340 0.6 1.8 2.05 2.29 3.38 2.22 HEMBB1002342 8.12 9.23 14.09 21.68 18.15 18.03 * + HEMBB1002358 1.09 3.22 6.37 6.52 7.91 9.2 HEMBB1002359 1.09 2.55 4.29 4.66 5.4 3.54 HEMBB1002364 1.28 1.82 2.33 3.17 5.15 3.11 HEMBB1002366 13.63 21.17 32.35 56.28 57.48 53.09 ** + HEMBB1002371 0.83 0.63 1.72 2.32 2.82 2.1 * + HEMBB1002381 0.97 1.16 1.74 2.83 3.16 6.26 HEMBB1002383 1.07 3.17 4.18 3.1 4.5 4.37 HEMBB1002387 0.98 2.36 2.68 2.09 3.68 2.96 HEMBB1002409 6.85 7.27 46.98 69.94 70.04 64.2 * + HEMBB1002413 3.92 2.99 8.34 9.46 8.16 10.16 HEMBB1002415 0.84 1.28 2.79 2.36 3.49 2.11 HEMBB1002424 1.04 1.17 1.63 2.89 3.04 2.66 ** + HEMBB1002425 1.12 1.69 5.86 6.46 10.1 5.26 HEMBB1002427 1.5 1.59 2.32 3.72 7.82 3.65 HEMBB1002442 2.29 1.57 4.33 4.99 8.58 8.89 * + HEMBB1002447 2.61 2.7 5.56 6.1 6.6 5.63 HEMBB1002453 2.5 2.48 6.56 6.31 7.55 5.25 HEMBB1002457 1.54 2.08 4.77 3.69 4.61 4.8 HEMBB1002458 0.48 1.53 2.5 2.2 2.35 1.66 HEMBB1002463 1.36 1.84 6.55 6.24 6.11 8.87 HEMBB1002465 1.12 1.18 2.4 2.86 2.25 1.59 HEMBB1002477 0.71 0.66 4.43 3 4.39 4.86 HEMBB1002479 22.08 21.58 27.54 16.12 19.41 17.27 * - HEMBB1002489 0.86 3.02 3.9 5.73 5.51 7.68 * + HEMBB1002492 1.27 1.23 3.07 3.53 4.08 3.39 * + HEMBB1002495 1.85 1.85 3.2 2.61 5.02 3.98 HEMBB1002502 0.94 2.52 2.81 1.77 4.83 3.27 HEMBB1002509 0.73 1.8 2.65 2.03 2.43 1.27 HEMBB1002510 0.49 1.68 3.06 1.78 2.5 0.81 HEMBB1002520 1.46 2.47 5.44 6.62 7.57 8.61 * + HEMBB1002522 0.82 1.88 4.42 2.31 6.8 2.07 HEMBB1002527 11.47 13.79 12.46 24.19 10.37 17.52 HEMBB1002530 1.43 2.15 3.44 2.93 4.92 2.26 HEMBB1002531 0.46 1.32 2.04 1.23 2.99 0.35 HEMBB1002534 1.35 2.27 2.73 4.54 4.08 3.92 ** + HEMBB1002536 6.58 5.93 46.38 45.93 63.71 42.88 HEMBB1002544 3.91 3.45 6.89 6.79 7.87 7.99 HEMBB1002545 0.92 2.76 2.83 3.21 4.15 4.29 HEMBB1002550 1.32 1.69 1.86 2.99 4.68 2.42 HEMBB1002556 2.9 3.54 9.69 8.73 8.12 10.62 HEMBB1002571 17.25 14.03 19.8 21.91 16.59 24.61 HEMBB1002579 3.32 2.05 4.87 4.38 6.6 6.39 HEMBB1002582 1.79 2.11 5.59 5.77 6.47 5.63 HEMBB1002584 2.82 1.94 6.09 3.94 4.67 3.62 HEMBB1002587 6.39 5.82 10.63 11.3 9.04 9.94 HEMBB1002590 1.6 3.07 7.46 5.86 7.3 5.84 HEMBB1002596 1.5 2.01 3.17 5.59 4.94 4.21 * + HEMBB1002600 1.55 2.72 3.81 5.02 7.18 3.93 HEMBB1002601 1.28 2.23 3.9 2.51 5.59 2.99 HEMBB1002603 2.37 1.64 5.48 3.53 6.59 5.6 HEMBB1002607 1.48 1.15 4.34 2.59 4.26 2.99 HEMBB1002610 1.2 0.96 3.48 1.95 3.79 3.45 HEMBB1002613 0.96 2.41 4.31 3.98 5.39 3.72 HEMBB1002614 3.18 3.34 5.35 3.87 6.08 9.76 HEMBB1002615 1.47 3.29 4.63 2.45 3.83 2.67 HEMBB1002617 0.67 3.09 2.88 2.1 3.34 3.4 HEMBB1002623 2.31 3.63 4.36 3.96 6.28 5.91 HEMBB1002624 2.7 1.56 7.52 7.96 8.72 8.3 HEMBB1002631 1.65 2 4.28 2.14 3.72 1.74 HEMBB1002635 1.84 1.74 3.55 3.31 3.64 3.56 HEMBB1002644 7.22 9.04 15.98 18.52 23.94 22.55 * + HEMBB1002654 5.22 4.21 7.77 7.92 7.33 11.74 HEMBB1002661 1.93 2.16 3.96 1.99 4.13 5.33 HEMBB1002663 1.59 1.8 3.85 5.45 5.58 5.17 * + HEMBB1002664 1.28 2.4 4.43 5.05 9.22 6.76 * + HEMBB1002677 1.88 1.83 1.86 1.81 4.79 2.34 HEMBB1002683 2.68 2.21 9.21 5.67 5.9 8.45 HEMBB1002684 1.71 0.81 2.53 1.92 2.74 2.63 HEMBB1002686 1.23 1.39 2.88 1.45 3.37 1.64 HEMBB1002692 0.99 1.4 1.87 2.5 2.53 2.98 * + HEMBB1002693 1.75 1.75 4.12 5.03 5.74 3.46 HEMBB1002697 1.09 2.8 2.73 4.17 5.58 5.34 * + HEMBB1002699 1.59 2.27 4.93 4.72 6.74 6.97 HEMBB1002702 1.63 1.5 2.54 1.76 3.25 3.33 HEMBB1002705 4.2 2.84 6.79 8.83 8.26 7.92 * + HEMBB1002712 8.55 1.32 2.38 2.92 4.06 1.4 IMR321000028 1.03 1.71 2.88 1.63 2.76 1.63 IMR321000031 1.71 2.59 3.51 5.86 4.35 5.31 * + IMR321000034 21.95 15.41 30.37 33.73 19.59 34.65 IMR321000039 5.81 7.11 14.41 14.72 15.71 13.99 IMR321000044 0.81 2.37 1.44 1.01 3.26 2.06 IMR321000063 79.52 80.12 127.61 224.23 199.69 128.8 IMR321000085 21.02 18.07 26.38 30.28 48.13 47.89 * + IMR321000089 1.51 1.42 3.86 3 6.7 5.84 IMR321000091 4.79 2.91 6.5 8.35 11.38 8.55 * + LIVER1000004 8.04 9.67 34.15 55.9 56.53 48.86 * + LIVER1000008 1.13 1.36 3.06 1.68 4 2.17 LIVER1000011 3.03 5.9 26.65 37.8 54.37 45.77 * + LIVER1000022 2.75 3.66 7.75 9.39 9.82 9.17 * + LIVER1000025 1.78 2.77 5.47 9.83 10.83 7.7 * + LIVER1000030 1.05 0.96 2.12 2.04 2.56 1.23 LIVER1000045 1.33 1.37 3.11 5.11 5.12 5.89 ** + LIVER1000046 1.01 1.53 3.86 4.14 7.82 5.34 LIVER1000072 1.61 1.26 5.23 12.42 9.54 12.21 ** + LIVER1000077 0.33 1.79 1.97 1.87 2.84 3.14 LIVER1000080 1.53 3 5.81 5.96 4.24 5.41 LIVER1000086 6.38 7.69 47.4 69.84 79.87 70.57 * + LIVER1000092 1.6 1.46 3.09 3.85 3.83 2.41 LIVER1000095 0.91 2.31 2.56 2.16 2.46 1.55 LIVER1000097 1.26 0.74 2.49 2.18 2.84 2.25 LIVER1000098 0.43 1.37 2.57 2.76 3.95 2.29 LIVER1000100 3.3 2.82 5.82 4.99 7.44 3.74 LIVER1000101 0.36 1.81 2.4 1.69 4.25 2.74 LIVER1000106 0.83 1.95 1.79 0.97 2.8 1.29 LIVER1000108 1.36 2.93 4.31 4.35 4.12 3.43 LIVER1000115 1.12 1.57 4.32 6.38 6.13 6.9 * + LIVER1000120 1.45 0.95 2.23 1.39 1.46 0.73 LIVER1000138 0.6 1.27 1.86 2.11 2.36 1.6 LIVER1000146 1.38 2.69 6.24 7.17 7.01 7.02 LIVER1000148 0.88 1.24 2.65 1.68 5.68 3.51 LIVER1000157 30.11 26.71 67.66 123.41 85.61 124.96 * + LIVER1000161 1.3 1.59 2.3 1.73 3.37 1.84 LIVER1000167 3.07 3.63 14.08 20.36 22.31 21.82 * + LIVER1000174 1.53 1.68 1.84 2.1 3.43 1.29 LIVER1000185 2.42 2.55 5.16 4.37 4.72 4.23 LIVER1000187 0.96 1.55 4.84 6.64 4.17 3.5 LIVER1000190 3.77 3.48 5.95 4.71 6.24 4.47 LIVER1000192 2.37 2.92 3.93 4.1 5.23 4.04 MAMMA1000009 1.39 2.55 5.12 3.62 4.72 3.46 MAMMA1000015 1.72 1.59 4.78 5.23 4.42 6.42 MAMMA1000019 0.69 2.48 3.4 4.27 4.81 3.1 MAMMA1000020 2.79 2.35 5.63 6 7.86 5.75 MAMMA1000024 0.65 1.76 3.79 2.42 2.91 1.61 MAMMA1000025 1.92 2.56 6.92 4.96 6.72 5.6 MAMMA1000043 1.06 2.36 6.43 6.93 8.22 6.6 MAMMA1000045 1.38 2.01 4.84 2.68 3.96 2.89 MAMMA1000046 1.74 2.44 3.18 2.88 4.5 2.37 MAMMA1000055 8.51 8.71 9.57 9.38 10.74 9.36 MAMMA1000057 4.4 3.29 7.56 8.38 9.78 8.16 MAMMA1000060 26.78 24.33 45.25 48.69 33.84 48.6 MAMMA1000069 2.13 1.65 4.1 3.43 3.14 2.41 MAMMA1000084 2.88 3 5.81 5.64 8.15 7.51 MAMMA1000085 2.75 3.74 7.02 6.45 5.82 6.97 MAMMA1000092 1.45 2.97 3.8 4.64 5.15 4.55 * + MAMMA1000096 4.45 4.96 9.29 8.15 9.11 6.09 MAMMA1000097 2.4 2.96 3.86 5.93 6.01 6.97 ** + MAMMA1000102 1.94 1.59 4.27 4.25 6.16 4.44 MAMMA1000103 1.52 1.65 5 2.39 4.56 2.83 MAMMA1000106 1.25 2.15 5.1 2.3 4.48 3.27 MAMMA1000117 1.19 2.12 3.72 1.84 3.32 2.77 MAMMA1000118 1.03 2.06 3.08 3.38 3.21 4.56 MAMMA1000129 1.06 2.1 2.97 1.73 2.7 1.31 MAMMA1000133 1.09 1.96 3.67 2.8 3.87 2.02 MAMMA1000134 1.23 2.08 4.28 2.27 4.61 1.93 MAMMA1000139 1.45 1.91 2.69 2.13 3.98 1.85 MAMMA1000141 1.97 2.27 5.47 3.67 3.61 3.42 MAMMA1000143 1.66 1.1 2.55 3.83 3.52 1.74 MAMMA1000150 4.11 4.95 8.99 6.49 6.4 8.66 MAMMA1000155 1.87 2.71 4.35 5.46 5.69 6.41 * + MAMMA1000163 1.65 2.82 2.62 3.45 4.54 4.97 * + MAMMA1000171 1.96 2.43 5.53 4.12 6.52 4.97 MAMMA1000173 3.5 5.27 10.33 17.47 17.44 18.26 ** + MAMMA1000175 1.58 1.8 2.89 4.06 5.14 3.7 * + MAMMA1000183 1.14 2.12 5.29 3.92 4.7 4.91 MAMMA1000191 3.25 3.34 14.68 12.56 14.7 18.23 MAMMA1000192 5.76 8.53 9.67 16.66 19.91 17.65 ** + MAMMA1000193 1.68 1.54 0.86 1.33 2.25 1.94 MAMMA1000198 1.88 1.99 5.53 4.44 6.49 5.57 MAMMA1000204 1.75 2.25 3.39 3.56 4.13 2.85 MAMMA1000207 1 3.2 3.41 2.86 4.96 3.47 MAMMA1000214 1.76 2.08 3.68 2.84 4.42 4.74 MAMMA1000220 6.19 6.12 11.61 12.49 18.06 16.72 * + MAMMA1000221 0.57 1.04 1.68 1.14 4.51 0.87 MAMMA1000226 0.48 1.06 2.07 1.49 3.19 1.88 MAMMA1000227 0.93 1.23 1.6 2.73 3.67 3.46 ** + MAMMA1000230 1 1.23 1.77 2.38 3.04 2.94 ** + MAMMA1000241 2.9 2.2 4.19 7.24 5.8 7.61 ** + MAMMA1000245 76.63 70.15 118.95 141.45 166.09 104.88 MAMMA1000248 6.79 4.17 13.48 13.18 13.44 18.8 MAMMA1000251 1.68 1.72 4.7 5.55 5.39 5.29 MAMMA1000254 1.24 1.22 3.59 2.14 5.61 5.02 MAMMA1000257 5.39 2.62 25.06 32.2 43.78 35.79 * + MAMMA1000262 15.48 9.75 18.2 40.81 33.23 34.89 ** + MAMMA1000264 0.99 1.2 2.3 4.43 2.57 3.4 * + MAMMA1000266 1.25 0.79 2.73 4.21 5.33 4.03 * + MAMMA1000270 2.43 1.94 4.57 6.16 7.16 7.58 * + MAMMA1000271 6.01 3.26 8.54 8.94 6.17 8.1 MAMMA1000277 0.89 0.93 2.56 2.46 2.75 2.09 MAMMA1000278 1.84 2.01 4.29 2.18 5.06 3.51 MAMMA1000279 1.82 1.74 4.33 3.51 5.72 4.35 MAMMA1000283 0.99 1.51 2.36 1.37 2.66 2.71 MAMMA1000284 2.65 2.51 8.31 6.28 8.49 8.01 MAMMA1000287 1.58 2.13 6.27 5.55 6.94 7.1 MAMMA1000294 4.72 5.45 9.44 3.84 8.21 4.74 MAMMA1000298 0.87 1.36 2.51 1.55 3.1 0.95 MAMMA1000302 0.9 1.18 4.73 2.22 4.9 2.56 MAMMA1000303 0.92 1.62 2.63 4.16 4.06 3.22 * + MAMMA1000305 1.07 1.28 2.73 2.47 2.74 2.1 MAMMA1000307 2.29 3.03 9.61 15.85 14.04 14.38 * + MAMMA1000309 0.57 1.61 3.69 4.6 3.65 4.61 MAMMA1000312 3.55 4.99 8.08 6.19 5.18 6.55 MAMMA1000313 1.06 2.31 2.34 1.79 3.98 3.43 MAMMA1000331 1.08 1.65 3 3.33 6.01 3.21 MAMMA1000335 7.38 9.1 14.27 19.49 16.28 16.92 * + MAMMA1000339 0.33 0.39 2.17 1.46 2.09 0.66 MAMMA1000340 1.43 1.33 4.12 4.37 2.72 2.15 MAMMA1000348 1.2 1.27 4.6 3.14 4.82 6.11 MAMMA1000356 1.93 2.21 4.93 3.08 5.42 6.29 MAMMA1000358 2.93 3.97 5.02 7.42 7.47 4.9 MAMMA1000360 1.41 1.92 4.6 3.76 5.2 4.63 MAMMA1000361 2.2 3.45 8.9 8.94 10.67 8.93 MAMMA1000363 1.09 1.69 3.86 1.87 4.37 4.1 MAMMA1000370 0.92 0.71 1.76 2.02 2.62 2.57 * + MAMMA1000371 2.09 1.73 6.35 10.02 12.1 10.1 * + MAMMA1000372 4.45 4.1 12.88 12.01 12.92 11.97 MAMMA1000385 1.79 2.36 6.41 6.41 7.66 8.72 MAMMA1000388 1.93 3.02 6.03 4.7 4.53 5.06 MAMMA1000395 1.3 2.46 3.12 1.69 3.49 0.8 MAMMA1000402 1.69 1.68 5.62 3.33 4.35 4.63 MAMMA1000403 1.7 2.36 5.05 5.45 5.81 3.96 MAMMA1000410 0.87 1.25 2.71 3.23 3.35 3.25 * + MAMMA1000413 1.52 0.47 2.48 3.51 3.76 3.61 * + MAMMA1000414 1.08 1.53 3.03 2.94 4.91 1.81 MAMMA1000416 3.3 4.01 10.2 15.8 23.14 20.47 * + MAMMA1000421 2.61 2.83 6.11 7.7 7.42 7.09 * + MAMMA1000422 2.83 2.53 7.46 9.18 6.64 12.05 MAMMA1000423 1.7 1.26 6 5.9 6.62 5.89 MAMMA1000424 0.88 1.7 3.17 1.91 2.38 1.07 MAMMA1000429 8.73 10.07 13.78 14.98 16.3 11.17 MAMMA1000431 1.6 1.27 4.27 5.22 6.32 4.26 MAMMA1000432 1.05 2.33 2.85 2.63 2.82 1.41 MAMMA1000437 4.61 4.75 8.44 10.54 11.52 8.12 MAMMA1000444 2.53 4.15 8.55 7.55 10.17 10.13 MAMMA1000446 1.19 2.07 3.87 2.03 3.63 2.49 MAMMA1000449 1.77 1.59 3.54 3.37 4.31 3.22 MAMMA1000457 4.44 4.82 7.12 7.2 6.88 6.22 MAMMA1000458 1.27 2.22 4.83 2.52 4.03 1.94 MAMMA1000468 0.55 1.12 2.2 0.51 2.25 1.16 MAMMA1000472 1.15 2.3 4.42 4.77 6.36 5.79 * + MAMMA1000473 1.95 1.72 3.59 3.45 5.46 3.17 MAMMA1000477 3.86 3.29 5.67 8.71 9.92 7.97 ** + MAMMA1000478 2.85 3.26 7.41 5.76 9.1 7.57 MAMMA1000483 4.16 3.16 8.3 8.09 6.5 8.63 MAMMA1000490 1.65 2.61 3.68 2.66 4.96 2.14 MAMMA1000496 1.18 1.7 3.44 1.3 3.79 2.01 MAMMA1000500 0.68 1.79 3.22 1.41 3.2 2.86 MAMMA1000501 3.04 3.89 7.86 13.71 15.02 12.51 ** + MAMMA1000503 0.84 2.08 2.21 3.52 3.52 2.27 MAMMA1000506 10.14 8.79 32.66 34.77 26.7 18.31 MAMMA1000510 3.24 3.5 4.59 10.97 10.76 13.61 ** + MAMMA1000515 2.12 1.54 4.56 5.97 7.55 6.2 * + MAMMA1000516 2.18 2.4 6.29 3.89 3.85 5.07 MAMMA1000522 1.04 1.47 4.39 2.4 3.68 1.85 MAMMA1000524 2.04 2.09 3.53 3.82 6.18 3.96 MAMMA1000528 3.74 2.72 2.05 2.7 4.09 2.88 MAMMA1000534 0.91 2.35 2.11 1.86 2.91 2.04 MAMMA1000541 2.85 3.16 11.29 11.22 8.81 12.04 MAMMA1000550 1.21 2.73 1.86 2.46 6.65 4.64 MAMMA1000556 1.78 1.32 4.25 2.66 3.37 1.4 MAMMA1000559 1.32 1.49 5.56 2.92 4.2 3.46 MAMMA1000565 1.82 2.74 3.93 2.13 4.18 4.22 MAMMA1000567 0.99 2.16 3.77 2.3 4.07 3.64 MAMMA1000576 3.72 3.12 13.12 10.45 9.76 10.02 MAMMA1000582 2.07 2.7 5.64 4.13 4.81 6.31 MAMMA1000583 1.16 2.33 2.45 2.19 4.47 2.93 MAMMA1000585 1.66 2.04 4.19 3.82 5.38 3.23 MAMMA1000587 1.64 1.51 3.73 3.12 5.07 3.49 MAMMA1000591 0.96 1.34 3.11 1.45 3.74 1.72 MAMMA1000594 2.3 1.76 4.92 3.55 7.68 5.16 MAMMA1000597 4.42 3.09 9.64 9.46 9.63 10.35 MAMMA1000605 2.84 3.94 11.44 18.34 15.85 17.89 * + MAMMA1000612 1.91 2.15 5.22 3.85 4.33 4.95 MAMMA1000614 3.11 2.71 9.4 7.48 6.07 6.34 MAMMA1000616 1.66 1.79 2.44 2.1 5.09 3.45 MAMMA1000621 1.39 1.67 3.36 3.15 6.31 7.02 MAMMA1000623 1.08 1.04 3.83 0.92 2.66 2.3 MAMMA1000625 7.39 6.32 23.76 19.68 25.39 29.8 MAMMA1000635 0.89 0.68 1.61 0.76 1.75 0.64 MAMMA1000643 1.47 1.11 1.94 4.21 3.77 6.82 * + MAMMA1000646 4.68 3.61 9.55 17.22 16.4 16.44 ** + MAMMA1000652 1.98 1.61 3.56 4.21 5.34 5.24 * + MAMMA1000657 2.28 1.78 4.51 2.18 4.48 3.26 MAMMA1000664 1.78 1.49 5.35 2.9 6.43 6.85 MAMMA1000667 1.24 1.68 2.17 1.96 5.64 2.41 MAMMA1000668 0.71 1.11 3.23 2.44 3.76 1.74 MAMMA1000669 0.76 0.97 2.01 0.9 3.94 2.06 MAMMA1000670 3.27 2.78 4.47 10.4 6.73 9.28 * + MAMMA1000672 1.71 3.23 6.88 5.43 5.63 6.03 MAMMA1000681 0.98 1.19 2.53 1.98 3.73 2.45 MAMMA1000684 6.87 11.61 18.54 30.76 32.53 30.62 ** + MAMMA1000696 1.64 3.39 4.99 7.89 14.39 8.69 * + MAMMA1000702 3.12 3.07 5.9 7.47 10.05 7.55 * + MAMMA1000706 0.63 1.07 1.79 1.08 1.52 0.66 MAMMA1000707 0.74 1.26 1.76 0.83 1.87 0.63 MAMMA1000713 1.53 2.14 5.33 5.43 5.8 6.96 MAMMA1000714 1.19 1.84 4.31 2.64 4.96 4.94 MAMMA1000718 1.32 2.79 4.84 5.53 7.12 4.37 MAMMA1000720 1.33 2.19 5.14 4.95 8.51 5.44 MAMMA1000723 1.22 1.65 4.17 3.26 4.81 3.68 MAMMA1000731 1.24 1.17 3.11 3.04 4.99 3.26 MAMMA1000732 1.37 1.59 3.02 4.86 6.5 6.05 ** + MAMMA1000733 0.58 0.82 1.54 2.31 2.41 1.22 MAMMA1000734 12.22 11.56 22.62 21.95 22.19 13.18 MAMMA1000736 4.26 4.34 11.96 4.92 5.77 6.14 MAMMA1000738 0.8 2.06 3.82 2.52 4.15 1.95 MAMMA1000744 1.12 2 5.52 3.27 3.97 4.67 MAMMA1000746 1 2.03 2.24 2.38 4.27 2.48 MAMMA1000748 8.23 8.93 13.13 15.53 16.06 15.05 * + MAMMA1000751 10.46 7.63 32.43 45.16 40.03 54.65 * + MAMMA1000752 1.5 2.37 8.68 11.52 14.2 12.68 * + MAMMA1000757 1.89 2.48 5.54 7.9 8.53 10.86 * + MAMMA1000760 3 2.99 6.77 4.65 8.01 7.12 MAMMA1000761 1.86 2.58 5.73 4.87 6.29 4.99 MAMMA1000775 1.37 1.83 4.43 3.23 4.29 2.64 MAMMA1000776 2.37 2.36 6.3 6.57 7 6.12 MAMMA1000778 2.14 2.28 5.19 4.95 3.99 3.84 MAMMA1000781 1.33 1.33 3.06 2.82 2.86 1.23 MAMMA1000782 1.94 2.36 3.88 2.93 3.11 3.01 MAMMA1000784 1.28 1.58 3.94 2.22 7.2 3.64 MAMMA1000788 3.05 4.31 4.38 4.16 5.12 2.21 MAMMA1000798 1.01 2.86 2.77 2.03 3.56 2.1 MAMMA1000802 4.36 3.71 8.23 17.49 15.39 19.2 ** + MAMMA1000810 3.91 4.98 14.15 17.58 19.04 16.15 * + MAMMA1000813 1.63 2.11 3.73 2.82 3.15 2.06 MAMMA1000814 2.56 2.97 7.82 7.28 7.26 6.61 MAMMA1000824 12.58 11.27 34.16 62.44 72.28 50.62 * + MAMMA1000827 1.83 2.04 5.05 3.3 4.77 4.31 MAMMA1000831 1.45 2.81 2.84 2.55 5.43 1.85 MAMMA1000838 6.85 9.27 7.86 13.01 8.43 14.52 MAMMA1000839 4.89 4.41 9 9.02 8.66 14.04 MAMMA1000841 1.33 2.02 3.11 2.23 4.44 2.29 MAMMA1000842 2.48 1.88 3.59 3.03 3.74 1.82 MAMMA1000843 1.26 2.19 3.88 2.26 4.43 2.35 MAMMA1000845 0.83 1.01 2.4 2.35 3.88 1.24 MAMMA1000851 1.3 3.42 5.35 7.83 5.9 6.65 MAMMA1000854 2.77 3.7 6.33 5.08 5.68 5.13 MAMMA1000855 0.37 2.97 2.62 2.51 3.74 1.78 MAMMA1000856 0.87 1.39 3.11 2.05 6.37 3.19 MAMMA1000859 9.88 8.56 20.5 19.52 18.47 24.31 MAMMA1000862 1.13 1.55 3.53 1.17 3.18 0.79 MAMMA1000863 2.62 2.08 4.72 2.59 5.24 4.91 MAMMA1000865 0.35 0.82 2.48 0.4 1.84 0.35 MAMMA1000867 1.08 2.83 2.87 1.95 3.68 4.76 MAMMA1000875 0.89 2.72 2.34 3.31 3.57 2.59 MAMMA1000876 1.23 1.64 4.59 2.4 3.37 3.22 MAMMA1000877 3.15 2.89 9.22 8.39 10.32 10.07 MAMMA1000878 3.05 3.61 8.94 6.33 8.52 9.62 MAMMA1000880 1.46 1.15 4.77 2.45 3.96 3.01 MAMMA1000881 1.81 2.09 4.52 3.77 6.07 4.73 MAMMA1000883 0.57 0.79 2.1 1.37 2.14 2.11 MAMMA1000897 0.76 2.39 0.36 1.19 2.99 6.19 MAMMA1000898 1.06 1.99 1.75 1.41 2.49 3.7 MAMMA1000905 1.8 2.75 4.68 8.32 6.86 10.64 * + MAMMA1000906 1.17 2.49 2.63 2.45 4.27 4.08 MAMMA1000908 1.59 1.63 4.3 1.77 3.05 1.43 MAMMA1000911 4.97 6.25 8.37 21.77 20.01 20.98 ** + MAMMA1000914 1.14 0.85 2.41 1.1 2.23 1.61 MAMMA1000920 1.99 2.17 4.41 10.82 10.67 9.11 ** + MAMMA1000921 1.03 1.02 2.41 3.47 3.84 3.17 * + MAMMA1000931 2.68 3.44 3.95 6.78 7.66 7.32 ** + MAMMA1000940 1.67 1.84 6.05 5.78 6.84 6.3 MAMMA1000941 3.74 2.55 8.61 9.01 10.11 9.46 MAMMA1000942 2.75 1.85 7.46 8.27 8.47 7.2 MAMMA1000943 2.16 2.84 10.49 9.04 11.08 8.74 MAMMA1000952 2.6 1.93 8.65 9.03 7.47 6.75 MAMMA1000956 0.93 1.24 3.11 3.64 3.1 3.47 MAMMA1000957 2.5 1.41 2.62 4.81 5.73 6.85 ** + MAMMA1000962 3.25 3.57 10.48 13.62 11.18 16.85 * + MAMMA1000966 1.85 2.19 6.04 6.34 6.23 7.04 MAMMA1000968 1.6 1.46 5.49 4.79 5.62 4.97 MAMMA1000972 2.4 1.41 3.83 3.34 3.91 4.32 MAMMA1000973 5.14 3.37 12.58 7.02 8.56 10.31 MAMMA1000975 1.44 1.99 3.34 2.37 4.9 5.05 MAMMA1000976 2.46 2.71 8.57 9.22 11.17 8.92 MAMMA1000979 1.46 2.62 3.06 4.34 4.41 7.71 MAMMA1000986 5.75 5.32 10.24 8.83 11.32 13.95 MAMMA1000987 1.44 1.36 3.99 2.43 3.74 5.66 MAMMA1000988 3.76 4.86 8.88 10.18 11.34 10.5 * + MAMMA1000994 9.82 7.58 15.88 12.02 11.56 9.25 MAMMA1000998 1.51 1.07 3.13 4.21 5.42 4.04 * + MAMMA1001003 1.98 1.83 5.97 4.2 6.86 4.39 MAMMA1001007 0.38 1.03 1.77 0.14 1.38 0.32 MAMMA1001008 11.76 11.09 40.52 56.73 50.93 45.37 * + MAMMA1001013 3.62 4.16 12.14 8.42 11.54 10.08 MAMMA1001014 1.4 1.79 5.49 4.36 5.16 4.26 MAMMA1001021 0.49 2.08 7.85 6.46 5.47 4.26 MAMMA1001024 0.85 1.59 3.14 2.55 3.92 1.96 MAMMA1001025 1.03 1.47 2.94 1.27 2.95 1.41 MAMMA1001028 1.3 1.09 2.23 3.07 4.73 3.28 * + MAMMA1001030 1.63 0.48 2.22 3.06 3.24 2.08 MAMMA1001035 2.48 2.92 10.31 9.29 11.92 11.54 MAMMA1001036 4.69 4.01 10.7 11.23 8.22 11.33 MAMMA1001037 1.91 2.88 6.49 5.28 7.53 4.69 MAMMA1001038 1.18 1.59 4.28 4.12 3.85 4.45 MAMMA1001041 1.64 1.87 3.18 3.75 4.04 2.64 MAMMA1001043 1.09 1.24 3.67 3.44 3.35 3.18 MAMMA1001050 1.52 1.55 5.94 8.4 8.28 6.51 * + MAMMA1001054 2.04 2.58 6.99 9.29 11.07 8.36 * + MAMMA1001059 2.66 4.71 9.73 8.85 9.72 8.46 MAMMA1001066 3.64 2.97 12.26 14.08 12.09 8.96 MAMMA1001067 1.26 2 4.77 3.53 5.33 3.29 MAMMA1001072 1.44 2.06 7.76 6.38 7.13 7.2 MAMMA1001073 1.17 0.79 1.47 1.49 2.74 1.34 MAMMA1001074 0.78 1.47 3.97 6.24 5.4 4.9 * + MAMMA1001075 4.87 4.41 10.48 11.24 9.82 8.21 MAMMA1001078 1.7 1.83 7.96 9.69 9.99 9.37 * + MAMMA1001080 3.77 3.93 6.97 8.71 10.33 5.57 MAMMA1001082 1.51 2.03 4.03 1.73 5.23 1.6 MAMMA1001091 1.17 1.36 2.02 1.81 3.03 1.47 MAMMA1001092 1.93 2.09 4.81 3.17 3.57 1.89 MAMMA1001094 1.73 4.28 4.65 4 5.62 4.7 MAMMA1001105 2.45 2.62 7.7 6.99 7.57 6.06 MAMMA1001110 0.4 1.01 2.74 1.42 2.53 0.47 MAMMA1001126 1.96 3.09 10.92 8.39 9.27 6.08 MAMMA1001133 2.5 3.44 10.94 9.48 10.83 10.68 MAMMA1001139 87.88 86.18 214.31 193.19 47.2 160.92 MAMMA1001141 1.33 2.89 3.65 3.69 5.25 5.46 MAMMA1001143 2.02 1.79 4.23 3.95 6.69 4.34 MAMMA1001145 3.1 2.22 3.39 6.37 7.13 2.84 MAMMA1001150 1.34 2.48 3.95 3.06 3.31 2.11 MAMMA1001154 2.16 2.8 5.57 5.44 7.13 5.22 MAMMA1001159 4.19 4.01 11.06 11.31 5.89 9.45 MAMMA1001161 4.3 5.27 19.53 18.34 10.8 14.8 MAMMA1001162 1.98 1.77 3.16 5.25 5.13 2.25 MAMMA1001181 2.44 2.28 4.87 5.06 4.74 3.62 MAMMA1001186 2 2.66 4.66 5.38 5.48 3.9 MAMMA1001189 2.23 3.68 7.17 11 11.17 9.9 * + MAMMA1001191 2.54 2.07 5.49 4.37 3.89 2.97 MAMMA1001198 368.47 416.05 784.82 647.17 738.61 605.52 MAMMA1001202 11.78 11.85 30.06 34.39 28.74 25.16 MAMMA1001203 2.57 3.01 7.15 8.72 6.26 5.56 MAMMA1001206 1.91 3.28 4.5 3.69 6.66 2.65 MAMMA1001208 2.66 2.93 3.31 3.82 4.95 3.19 MAMMA1001215 2.9 3.08 6.55 3.49 8.09 4.74 MAMMA1001220 2.63 3.03 7.25 7.16 7.17 6.03 MAMMA1001222 1.25 1.18 4.18 2.18 5.85 0.53 MAMMA1001223 2.48 3.32 6.53 4.95 6.51 4.1 MAMMA1001232 2.82 4.27 8.08 12.22 8.82 9.57 MAMMA1001234 1.25 3.27 3.17 5.05 3.91 3.26 MAMMA1001237 1.22 1.56 4.21 1.94 3.66 2.09 MAMMA1001243 2.18 2.28 4.06 4.05 4.89 1.99 MAMMA1001244 1.22 1.16 2.86 2.96 4.79 2.22 MAMMA1001249 2.3 1.89 5.93 5.19 5.8 3.75 MAMMA1001256 3 3.09 8.29 5.89 7.83 8.01 MAMMA1001259 4.38 3.25 7.15 7.94 9.24 6.63 MAMMA1001260 1.76 2.71 5.42 6.51 5.33 7.33 MAMMA1001262 2.1 4.11 5.28 7.86 8.04 6.25 * + MAMMA1001268 2 2.16 4.59 2.56 4.23 2.48 MAMMA1001271 4.84 5.78 17.37 18.29 14.24 15.67 MAMMA1001274 2.88 3.06 6.17 6.22 8.55 7.93 MAMMA1001280 2.09 1.48 4.36 1.84 3.78 1.73 MAMMA1001283 1.63 1.71 6.34 6.88 5.63 4.83 MAMMA1001284 2.27 2 8.67 5.08 9.09 9.51 MAMMA1001286 13.83 9.72 17.39 12.15 11.83 14.63 MAMMA1001289 17.63 13.49 23.32 21.02 26.39 36.8 MAMMA1001292 3 3.01 5.94 7.26 6.31 6.85 * + MAMMA1001296 3.55 3.76 12.61 14.11 12.37 12.8 MAMMA1001298 1.26 1.7 6.26 4.25 6.78 4.07 MAMMA1001305 0.86 1.59 4.43 2.49 4.07 2.63 MAMMA1001309 0.61 0.9 2.7 1.84 3 1.49 MAMMA1001310 1.72 2.17 3.64 4.81 7.38 4.42 MAMMA1001322 0.99 1.54 1.83 2.83 1.77 2.13 MAMMA1001324 1.3 1.12 3.16 2.03 2.83 1.94 MAMMA1001330 3.35 2.65 9.53 7.93 9.75 5.36 MAMMA1001333 3.1 3.74 10.23 9.88 11.4 9.07 MAMMA1001334 5.53 4.17 4.83 10.97 8.23 10.16 ** + MAMMA1001337 2.49 3.54 6.6 6.99 9.16 8.05 * + MAMMA1001341 1.21 1.14 3.48 1.54 5.66 1.41 MAMMA1001343 2.37 1.89 8.07 8.17 9.75 10.95 MAMMA1001344 9.59 9.07 11.75 13.63 11.67 15.98 MAMMA1001346 1.34 1.25 3.9 2.05 3.9 2.94 MAMMA1001383 3.07 3.61 8.52 8.3 9.02 9.38 MAMMA1001388 1.62 1.93 5.34 3.38 6.11 4.58 MAMMA1001396 4.2 2.12 8.12 11.39 10.42 8.68 MAMMA1001397 2.59 2.27 5.79 8.33 8.96 7.78 * + MAMMA1001401 26.87 16.48 32.72 43.47 57.55 45.66 * + MAMMA1001408 1.06 1.06 2.57 0.65 4.22 1.19 MAMMA1001411 1.65 1.26 3.84 4.38 3.33 3.51 MAMMA1001414 3.12 3.85 5.74 12.58 10.67 15.28 ** + MAMMA1001415 2.45 3.16 11.93 14.57 20.15 13.69 * + MAMMA1001418 0.66 2.2 5.36 3.57 6.04 4.46 MAMMA1001419 0.8 2.43 4.93 6.03 7.01 3.92 MAMMA1001420 0.96 3.09 4.5 3.23 4.11 3.41 MAMMA1001426 20.24 32.21 42.42 44.31 39.63 38.75 MAMMA1001428 1.94 2.83 6.35 3.8 6.93 4.33 MAMMA1001432 1.19 2.33 8.19 5.62 6.19 6.68 MAMMA1001435 1.43 0.78 3.32 3.48 3.67 2.64 MAMMA1001442 1.96 3.94 7.41 8.18 8.6 6.63 MAMMA1001446 2.17 2.57 6.71 6.9 7.34 7.97 MAMMA1001450 1.22 2.05 3.58 2.81 4.18 2.39 MAMMA1001452 1.99 1.78 5.92 8.38 6.19 4.83 MAMMA1001465 3.93 3.25 13.61 16.65 14.6 13.82 MAMMA1001476 1.63 1.09 4.25 5.87 5.95 4.64 * + MAMMA1001478 2.28 2.12 5.98 3.55 6.27 4.19 MAMMA1001479 3.11 4.71 8.32 5.58 6.74 6.21 MAMMA1001487 1.1 1.14 3.84 4.73 3.26 2.08 MAMMA1001498 1.93 3.41 7.78 6.17 7.45 5.64 MAMMA1001501 0.88 1.97 4.49 2.8 4.77 2.36 MAMMA1001502 1.82 1.91 6.48 3.29 6.29 6.26 MAMMA1001510 0.48 0.78 2.92 0.54 3.04 1.19 MAMMA1001522 1.03 1.29 3.94 5.05 4.9 3.39 MAMMA1001529 0.72 2.06 3.22 3.74 4.07 2.57 MAMMA1001532 1.74 1.86 4.27 3.79 5.71 3.12 MAMMA1001533 0.61 1.31 2.9 1.52 3.06 1.64 MAMMA1001534 0.44 2.59 2.4 1.48 3.64 1.14 MAMMA1001535 1.38 1.91 3.99 2.12 3.98 2.38 MAMMA1001547 2.8 2.89 7.77 9.23 8.22 6.22 MAMMA1001551 1.1 1.48 4.46 2.23 2.88 2.99 MAMMA1001569 1.27 1.68 3.41 2.03 3.41 1.94 MAMMA1001575 1.48 2.41 3.42 4.01 4.43 2.81 MAMMA1001576 4.79 8.23 9.65 14.75 9.39 17.03 MAMMA1001584 0.89 2.48 3.33 3.11 4 3.09 MAMMA1001586 1.43 2.41 3.34 3.78 3.31 1.84 MAMMA1001590 2.96 2.53 5.55 5.44 6.47 6.04 MAMMA1001599 4.64 7.15 16.79 15.8 15.18 15.06 MAMMA1001600 1.45 2.22 4.73 2.98 4.68 2.11 MAMMA1001604 1.03 1.76 3.62 2.35 4.01 1.64 MAMMA1001606 1.64 2.04 5.15 3.58 5.45 4.27 MAMMA1001609 1.31 2.37 4.36 3.05 5.43 1.59 MAMMA1001614 2.91 3.57 6.15 5.94 6.11 4.14 MAMMA1001615 3.98 2.61 10.12 8.87 8.29 8.41 MAMMA1001619 7.73 7.8 14.29 16.33 12.93 14.61 MAMMA1001620 2.53 2.41 7.98 5.77 7.13 4.54 MAMMA1001623 4.11 4.58 9.3 7.34 9.28 6.75 MAMMA1001626 0.83 1.98 2.52 3.24 3.93 1.93 MAMMA1001627 1.11 1.98 3.57 2.63 3.68 1.63 MAMMA1001630 2.02 3.08 7.83 7.49 7.53 4.29 MAMMA1001633 2.64 3.12 8.8 12.09 9.59 6.16 MAMMA1001634 2.83 2.7 6.11 8.69 8.27 6.9 * + MAMMA1001635 5.65 2.39 9.52 7.92 8.3 8.37 MAMMA1001649 1.61 1.63 4.71 2.95 4.62 2.53 MAMMA1001654 8.14 9.45 39 43.4 55 46.79 MAMMA1001660 19.61 17.92 37.43 40.94 27.03 34 MAMMA1001663 1.9 4.73 9.42 9.59 9.56 6.58 MAMMA1001670 1.12 2.66 3.97 3.65 4.09 2.62 MAMMA1001671 1.08 1.42 3.56 1.37 4.64 1.77 MAMMA1001679 6.85 6.37 13.89 11.48 17.04 13.91 MAMMA1001683 2.15 3.29 9.6 6.58 6.53 6.96 MAMMA1001686 1.25 1.34 3.77 1.39 2.97 3.06 MAMMA1001688 113.39 113.61 245.56 392.2 458.41 413 ** + MAMMA1001689 1.01 3.76 4.1 5.04 3.79 4.44 MAMMA1001692 1.97 2.59 5.37 3.66 5.3 3.88 MAMMA1001711 1.99 3.64 8.65 4.35 5.51 6.1 MAMMA1001715 1.31 1.64 3.95 4.64 4.87 4.13 MAMMA1001730 2.01 2.15 2.5 2.8 4.42 2.83 MAMMA1001735 44.73 48.32 102.35 94.99 156.23 119.88 MAMMA1001740 0.64 1.6 4.59 2.06 3.91 1.95 MAMMA1001743 9.84 11.15 33.16 41.97 51.62 49.6 * + MAMMA1001744 0.63 0.72 0.86 1.1 1.72 1.71 * + MAMMA1001745 1.41 2.15 6.15 3.27 4.46 3.93 MAMMA1001751 1.38 2.41 3.24 2.85 4.51 4.32 MAMMA1001752 4.7 4.78 9.75 6.12 9.61 8.4 MAMMA1001754 7.25 7.89 7.34 11.04 9.63 9.39 * + MAMMA1001757 1.21 1.1 2.32 2.21 3.25 2.43 MAMMA1001760 3.87 4.52 20.01 22.91 24.2 27.59 * + MAMMA1001764 2.62 2.36 5.97 7.13 10.17 6.51 MAMMA1001767 1.22 1.55 2.13 1.61 2.96 1.55 MAMMA1001768 0.57 1.18 4.25 4.74 4.72 4.37 MAMMA1001769 2.48 2.83 9.22 9.3 9.81 8.94 MAMMA1001771 2.66 1.58 3.74 2.86 5.85 6.77 MAMMA1001773 2.7 3.53 3.87 4 6.29 7.61 MAMMA1001778 0.88 1.92 3.14 3.13 4.21 3.61 MAMMA1001783 2.01 2.1 11.25 11.63 18.46 13.04 MAMMA1001785 3 3.52 8.85 10.56 13.38 11 * + MAMMA1001788 0.49 0.86 1.21 0.72 1.72 1.11 MAMMA1001790 1.68 1.67 5.1 2.37 3.73 3.93 MAMMA1001800 0.83 0.99 1.47 1.5 2.24 3.25 MAMMA1001804 1.02 1.41 3.18 2.37 4.16 2.4 MAMMA1001806 2.13 2.78 6.4 3.15 5.5 4.72 MAMMA1001812 1.46 1.33 5.52 4.21 5.86 5.05 MAMMA1001815 0.33 1.76 3.07 1.22 3.67 1.24 MAMMA1001817 3.19 3.38 9.5 6.78 10.89 13.3 MAMMA1001818 1.68 2.08 3.41 3.94 8.52 3.41 MAMMA1001819 2.57 4.12 5.82 8.7 10.29 7.87 * + MAMMA1001820 2.68 4.51 8.27 7.51 10.98 6.07 MAMMA1001824 1.66 2.83 8.36 7.55 9.8 7.11 MAMMA1001832 6.72 7.99 11.85 20.17 21.28 17.21 ** + MAMMA1001836 1.74 1.66 5.08 4.79 8.19 4.88 MAMMA1001837 2.61 2 5.84 7.1 9.19 5.37 MAMMA1001848 1.02 1.61 3.3 2.81 5.33 3.18 MAMMA1001850 3.79 4.51 9.31 9.98 9.93 14.19 MAMMA1001851 1.49 2.33 4.98 4.97 4.12 4.02 MAMMA1001852 2.98 4 9.68 6.4 7.56 6.8 MAMMA1001854 2.56 3.11 9.16 10.59 10.64 9.98 MAMMA1001858 3.11 2.22 5.28 9.93 7.91 8.87 ** + MAMMA1001864 1.69 1.91 4.09 8.91 6.18 4.37 MAMMA1001868 0.71 0.92 2.64 1.68 2.58 0.91 MAMMA1001874 1.2 0.87 2.52 1.06 3.48 1.17 MAMMA1001878 3.1 3.46 10.86 7.7 13.37 6.77 MAMMA1001880 2.67 2.99 7.24 5.58 7.17 8.12 MAMMA1001885 1.14 1.93 6.19 4.7 5.54 4.58 MAMMA1001890 3.54 3.95 12.93 13.59 13.29 12.2 MAMMA1001893 3.74 3.42 6.25 6.59 5.49 5.58 MAMMA1001901 1.13 1.5 5.4 4.53 5.72 2.67 MAMMA1001907 2.57 1.62 6.43 4.15 7.36 6.34 MAMMA1001908 3.2 3.36 8.35 11.83 12.96 12.46 * + MAMMA1001919 0.23 0.97 3.3 2.24 3.9 2.07 MAMMA1001931 0.76 1.65 4.04 3.36 5.89 3.25 MAMMA1001937 2.27 3.15 5.5 6.44 5.06 3.78 MAMMA1001951 1.74 2.57 6.47 6.48 6.15 4.83 MAMMA1001956 3.02 3.48 9.72 8.52 7.66 6.76 MAMMA1001957 3.39 3.51 9.15 7.88 9.47 7.66 MAMMA1001960 3.1 3.34 7.24 12.06 9.14 6.1 MAMMA1001963 0.57 0.78 2.14 1.3 2.36 1.06 MAMMA1001969 1.7 3.43 10.86 8.54 11.14 8.74 MAMMA1001970 2.86 3.04 8.48 13.11 6.59 6.64 MAMMA1001978 0.57 1.85 1.76 2.42 3.87 1.53 MAMMA1001992 2.07 2.04 5.65 6.79 6.75 5.09 MAMMA1001994 7.97 3.65 11 18.83 13.23 17.17 * + MAMMA1002008 3.28 3.77 6.42 3.43 4.06 1.24 MAMMA1002009 1.46 2.94 5.17 5.73 7.57 4.06 MAMMA1002011 1.77 1.71 4.26 6.5 6.45 3.37 MAMMA1002022 1.51 2.1 5.92 6.64 7.42 5.2 MAMMA1002024 9.79 9.67 19.03 17.61 16.96 22.43 MAMMA1002032 2.78 2.41 7.25 5.29 6.16 8.07 MAMMA1002033 3.23 3.95 7.73 11.24 7.23 6.62 MAMMA1002041 2.87 2.25 3.18 4.74 5.39 1.71 MAMMA1002042 2.54 2.34 5.66 5.65 5.78 3.76 MAMMA1002045 2.33 3.51 7.28 8.39 5.05 4.44 MAMMA1002047 2.58 2.98 8.83 8.7 8.9 6.89 MAMMA1002056 2.01 5.78 11.14 11.35 10.64 9.14 MAMMA1002058 1.67 2.61 8.19 4.84 4.66 4.27 MAMMA1002060 1.08 2.08 1.41 2.5 4.09 1.2 MAMMA1002065 1.81 2.75 6.04 7.19 5.19 3.26 MAMMA1002068 2.43 1.84 5.29 4.98 5.6 4.47 MAMMA1002070 4.5 2.92 4.15 2.58 5.23 2.81 MAMMA1002078 1.32 1.43 2.94 1.12 4.4 1.07 MAMMA1002080 7.98 9.71 13.38 14.92 20.84 14.26 MAMMA1002082 2.54 4.96 13.04 9.67 8.15 7.78 MAMMA1002084 1.78 3.47 3.38 4.68 4.48 3.6 MAMMA1002087 1.12 2.15 5.37 3.6 4.67 2.36 MAMMA1002091 3.79 3.22 4.32 7.18 6.76 6.41 ** + MAMMA1002093 0.72 1.4 4.31 2.74 4.39 2.33 MAMMA1002095 2.4 3.22 7.5 4.73 7.52 4.54 MAMMA1002108 1.84 1.02 2.63 1.87 3.24 1.31 MAMMA1002112 2.94 3.4 7.03 12.79 16.02 11.28 ** + MAMMA1002118 1.02 1.61 2.24 1.41 3.18 2.01 MAMMA1002119 0.76 2.15 3.61 1.51 3.12 2.54 MAMMA1002125 1.79 2.61 6.95 4.52 4.19 4.11 MAMMA1002126 3.72 4.25 9.79 10.08 9.02 11.03 MAMMA1002128 0.9 2.36 3.07 2.7 3.49 2.88 MAMMA1002132 3.78 3.24 11.42 6.18 9.05 6.81 MAMMA1002140 1.46 1.87 3.68 2.18 3.24 2.33 MAMMA1002142 3.13 3.43 7.06 5.18 7.62 5.46 MAMMA1002143 5.42 2.27 7.96 7.98 9.87 13.23 MAMMA1002145 1.47 1.34 3.3 2.9 4.02 2.64 MAMMA1002147 0.81 1.59 2.9 2.71 4.4 3 MAMMA1002153 0.99 1.92 5.55 3.52 6.41 4.75 MAMMA1002155 2.11 1.93 6.76 4.4 6.46 4.46 MAMMA1002156 0.81 0.8 1.94 0.67 2.63 0.78 MAMMA1002158 1.38 1.83 5.12 4.09 7.73 5.2 MAMMA1002164 2.01 2.09 5.86 3.17 3.18 4.04 MAMMA1002165 4.04 4.29 7.25 8.65 8.1 6.81 MAMMA1002170 1.01 1.48 154.53 2.65 3.24 4.11 MAMMA1002174 1.66 2.9 5.88 4.55 7.78 8.58 MAMMA1002175 3.27 3.3 7.02 6.95 6.64 7.22 MAMMA1002180 8.59 6.53 35.97 55.49 48.49 51.08 * + MAMMA1002198 3.11 2.3 9.33 7.6 11.22 7.13 MAMMA1002205 2.93 1.66 6.15 6.3 8.04 7.54 MAMMA1002206 4.6 3.59 8.14 12.4 13.97 11.74 ** + MAMMA1002209 1.7 1.93 4.03 4.43 4.23 4.57 MAMMA1002215 4.17 2.72 15.2 11.05 12.43 17.14 MAMMA1002219 1.57 1.96 4.99 4.84 6.34 5.96 MAMMA1002224 3.18 2.9 8.18 5.49 7.25 5.86 MAMMA1002229 3.74 2.21 8.83 8.48 9.26 6.82 MAMMA1002230 2.02 2.21 6.63 5.31 8.91 6.58 MAMMA1002233 3.01 1.6 6.08 4.21 7.91 6.14 MAMMA1002234 3.05 3.06 6.7 8.6 10.45 10.76 * + MAMMA1002236 4.13 3.68 14.08 26.56 20.38 24.71 * + MAMMA1002243 0.97 2.48 3.48 3.28 3.43 2.96 MAMMA1002250 1.06 2.09 5.2 3.95 6.82 6.01 MAMMA1002253 2.77 2.39 3.45 4.84 6.18 3.37 MAMMA1002267 17.17 19.95 51.7 130.02 108.53 115.75 ** + MAMMA1002268 1.72 2.28 5.82 6.92 11.3 6.52 MAMMA1002269 0.89 0.73 2.25 2.32 2.58 1.67 MAMMA1002282 0.86 1.09 4.95 5.87 5.31 6.81 MAMMA1002292 2.71 2.25 7.77 10.57 10.52 11.53 * + MAMMA1002293 3.71 3.31 12.81 8.54 10.47 12.05 MAMMA1002294 0.9 1.71 4.61 3.68 6.03 4.2 MAMMA1002297 1.53 3.25 7.45 5.77 7.8 6.91 MAMMA1002298 1.48 1.4 3.98 3.85 3.11 2.46 MAMMA1002299 1.5 1.69 3.16 3.91 2.97 2.2 MAMMA1002308 1.39 1.35 6.55 4.5 3.11 2.54 MAMMA1002310 3.56 3.84 12.73 9.92 12.66 11.48 MAMMA1002311 2.52 2.13 6.82 9.61 9.66 6.9 * + MAMMA1002312 1.63 2.22 5.19 3.51 8.45 2.55 MAMMA1002317 2.08 2.55 4.89 4.08 3.85 4.09 MAMMA1002319 0.8 2.78 3.51 2.68 3.97 2.85 MAMMA1002322 2.48 3.23 7.84 12.21 10.02 8.55 * + MAMMA1002329 1.64 1.67 2.93 2.9 3.3 2.76 MAMMA1002332 2.17 2.38 4.58 5.98 4.14 3.05 MAMMA1002333 1.7 1.74 4.19 5.35 5.07 3.54 MAMMA1002335 1.75 2.72 8.53 6.93 11.32 4.23 MAMMA1002339 2.09 2.42 7.34 5.21 7.5 5.14 MAMMA1002347 1.7 2.3 6.39 5.5 5.32 4.64 MAMMA1002351 2.08 2.68 5.74 3.03 4.48 4.84 MAMMA1002352 1.27 2.28 3.66 3.53 4.63 2.8 MAMMA1002353 4.46 2.5 5.84 5.95 4.19 4 MAMMA1002355 3.97 3.38 8.37 7.98 7.31 8.57 MAMMA1002356 2.18 1.49 4.36 5.43 4.13 3.75 MAMMA1002359 3.95 3.35 16.09 23.81 24.53 19 * + MAMMA1002360 0.93 1.73 3.77 2.48 3.2 1.67 MAMMA1002361 2.01 2.64 4.53 4.17 4.95 4.03 MAMMA1002362 2.33 2.33 3.36 5.31 5.51 3.99 * + MAMMA1002367 2.97 3.64 14.63 18.34 21.06 21.56 * + MAMMA1002371 2.28 3.75 8.3 6.15 6.74 5.88 MAMMA1002380 1.81 2.26 4.9 4.71 5.76 3.55 MAMMA1002384 2.14 1.53 4.73 4.48 5.36 4.05 MAMMA1002385 1.19 2.05 5.63 3.34 4.8 2.47 MAMMA1002390 1.41 2.04 3.75 5.48 5.4 3.43 MAMMA1002392 1.94 3.1 6.1 4.06 5.95 3.32 MAMMA1002396 4.87 3.49 12.87 10.79 12.9 8.08 MAMMA1002399 4.42 5.13 10.69 10.95 8.66 4.57 MAMMA1002400 3 2.22 4.69 3.11 4.36 3.53 MAMMA1002409 51.57 55.16 63.3 77.54 80.62 77.88 ** + MAMMA1002411 1.08 1.88 4.13 3.43 5.49 1.92 MAMMA1002413 2.02 3.01 9.19 5.93 7.17 6.75 MAMMA1002417 1.83 2.24 4.87 3.45 4.25 2.63 MAMMA1002427 1.5 2.38 4.54 4.78 5.56 3.41 MAMMA1002428 2.47 2.26 5.38 4.46 5.11 4.28 MAMMA1002433 1.74 2.18 6.84 6.72 6.96 6.22 MAMMA1002434 2.94 2.4 7.38 5.34 4.65 5.03 MAMMA1002446 1.39 2.34 5.62 3.98 5.84 5.96 MAMMA1002447 2.51 1.38 6.4 5.11 6.26 5.45 MAMMA1002454 7.77 9.16 18.07 21.71 17.12 18.35 MAMMA1002461 2.06 4.11 7.7 4.92 5.41 6.47 MAMMA1002463 3.28 3.32 8.09 6.98 7.82 5.39 MAMMA1002464 16.58 16.77 20.05 19.41 20.41 18.09 MAMMA1002466 9.48 9.89 14.22 14.58 15.75 13.93 MAMMA1002470 1.39 1.51 5.13 3.54 5.01 3.73 MAMMA1002475 0.72 1.85 5.03 3.86 5.17 4.65 MAMMA1002480 0.66 1.21 2.31 1.68 2.84 2.03 MAMMA1002485 29.98 27.24 46.09 64.83 74.9 80.68 ** + MAMMA1002494 2 2 4.11 4.48 5.12 5.13 * + MAMMA1002498 0.97 2.57 3.16 2.07 3.18 1.55 MAMMA1002524 3.04 2.96 6.43 5.18 7.34 6.1 MAMMA1002530 2.5 3.24 4.88 3.17 4.41 2.55 MAMMA1002538 2.34 2.38 5.62 5.46 5.13 4.91 MAMMA1002545 2.37 2.64 6.26 4.56 6.49 4.56 MAMMA1002554 1.96 1.42 5.43 5.3 6.01 7.81 MAMMA1002556 1.3 1.9 3.6 3.73 5.75 3.89 MAMMA1002561 2.3 2.99 7.19 8.13 10.46 7.98 MAMMA1002565 1.22 2.15 3.52 2.57 4.51 2.55 MAMMA1002566 0.98 1.87 6.21 1.65 4.7 3.9 MAMMA1002571 0.53 1.8 3.06 1.43 3.1 4.3 MAMMA1002573 2.14 1.86 7.06 4.54 5.66 5.97 MAMMA1002576 118.77 131.84 363.97 348.62 471.73 358.66 MAMMA1002584 3.52 2.27 11.91 12.86 17.82 13.46 MAMMA1002585 0.76 1.86 4.38 1.85 3.6 5.26 MAMMA1002586 1.98 2.55 3.85 4.12 5.02 3.3 MAMMA1002589 1.08 1.26 2.44 2.36 5.06 3.19 MAMMA1002590 1.01 1.57 5.87 2.58 6.75 4.57 MAMMA1002593 2.48 2.48 4.89 4.18 4.07 3.04 MAMMA1002597 2.47 2.52 7.25 8.06 9.48 8.78 * + MAMMA1002598 12.12 13.52 30.83 37.28 48.14 38.91 * + MAMMA1002603 1.2 1.39 3.69 3.25 6.24 4.35 MAMMA1002612 3.51 3.39 12.6 7.66 7.78 9.76 MAMMA1002617 4.3 3.41 10.15 6.3 7.29 10.05 MAMMA1002618 1.68 2.27 4.02 2.76 3.59 3.91 MAMMA1002619 2.96 2.8 5.24 3.22 5.88 3.49 MAMMA1002622 2.51 2.12 8.02 7.1 7.18 7.15 MAMMA1002623 2.31 2.21 6.27 5.89 6.17 6.19 MAMMA1002625 1.32 1.3 3.23 2.3 6.42 2.6 MAMMA1002627 0.98 0.82 2.93 0.6 1.29 0.21 MAMMA1002629 1.8 2.23 6.09 5.03 6.74 7.02 MAMMA1002631 1 1.86 3.61 3.07 4.55 2.97 MAMMA1002633 6.61 7.44 21.47 19.33 24.55 21.53 MAMMA1002636 1.02 2.46 6.97 6.79 8.77 9.25 MAMMA1002637 1.05 1.4 4.66 3.39 4.85 4.28 MAMMA1002646 1.69 0.8 3.32 2.33 2.86 1.53 MAMMA1002648 10.51 14.07 21.18 42.29 31.45 39.76 ** + MAMMA1002650 1.33 0.56 1.62 1.76 2.08 0.57 MAMMA1002652 1.76 2.82 7.31 7.5 7.41 9.79 MAMMA1002655 1.7 2.11 3.65 2.54 4.23 3.78 MAMMA1002662 0.84 2.24 4.33 3.57 5.68 4.13 MAMMA1002665 3.61 3.57 10.05 13.42 17.97 19.59 * + MAMMA1002671 2.84 3.63 10.17 17.04 16.47 19.3 ** + MAMMA1002673 1.32 2.14 4.93 4.07 5.03 2.82 MAMMA1002684 2.95 3.11 3.84 6.61 8.19 7.54 ** + MAMMA1002685 0.68 1.49 2.57 2.05 3.74 2.97 MAMMA1002692 1.28 1.96 5.45 2.46 4.14 3.62 MAMMA1002693 1.84 4.18 8 4.63 7.68 6.61 MAMMA1002698 0.99 1.91 4.05 2.92 4.42 3.3 MAMMA1002699 2 2.35 4.43 4.05 5.22 3.64 MAMMA1002701 2.41 2.56 8.46 6.72 8.94 8.93 MAMMA1002708 1.51 1.55 5.38 4.08 6.16 6.18 MAMMA1002711 1.58 2.08 7.04 4.37 7.35 5.81 MAMMA1002712 3.05 3.13 6.98 4.88 7.12 7.39 MAMMA1002716 0.56 1.75 3.39 2.38 6.29 2.9 MAMMA1002721 2.11 2.01 5.57 3.72 6.34 4.59 MAMMA1002723 2.43 2.46 4.91 3.85 5.98 4.88 MAMMA1002727 3.85 5.55 5.78 5.29 4.45 6.22 MAMMA1002728 21.35 22.03 57.81 49.09 54.73 65.13 MAMMA1002742 4.12 4.39 10.35 7.92 8.63 7.61 MAMMA1002743 4.12 3.89 6.17 13.81 14.09 13.46 ** + MAMMA1002744 2.07 3.15 9.18 9.33 12.98 13.16 MAMMA1002746 0.93 1.28 3.09 2.29 4.31 1.68 MAMMA1002748 2.71 2.65 4.52 7.15 5.86 4.72 * + MAMMA1002754 1.12 2.41 5.56 5.05 5.65 6.26 MAMMA1002758 0.71 1.66 2.55 1.57 4.41 1.69 MAMMA1002762 11.3 11.14 36.64 38.42 34.23 48.71 MAMMA1002764 1.83 3.2 5.95 5.11 6.06 4.26 MAMMA1002765 1.19 1.63 4.29 4.63 5.26 2.67 MAMMA1002769 7.4 6.44 13.04 13.78 8.03 12.41 MAMMA1002771 1.41 2.41 3.31 3.54 5.39 4.39 MAMMA1002775 4.56 4.48 19.79 22.54 29.77 24.29 * + MAMMA1002780 2.59 1.83 3.03 2.11 4.89 3.78 MAMMA1002782 1.43 2.49 3.85 2.51 4.79 4.11 MAMMA1002795 1.89 2.03 3.46 6.45 7.68 5.35 ** + MAMMA1002796 4.35 3.97 7.51 7.2 8.09 8.17 MAMMA1002805 6.61 11.12 16.52 15.95 24.7 16.5 MAMMA1002806 1.47 2.02 3.51 2.28 4.62 2.17 MAMMA1002807 1.63 2.4 6.77 6.78 9.66 6.4 MAMMA1002814 3.43 3.52 7.92 9.58 12.39 10.66 * + MAMMA1002817 1.28 1.56 2.87 2.89 5.43 2.91 MAMMA1002820 1.66 1.93 2.61 2.52 4.77 2.21 MAMMA1002830 67.67 70.46 130.59 165.92 139.33 187.18 * + MAMMA1002833 4.16 2.88 9.4 8.22 10.68 10.58 MAMMA1002835 0.77 1.87 4.03 1.73 3.97 2.79 MAMMA1002838 1.85 2.66 5.31 2.91 4.44 3.93 MAMMA1002842 1 3.83 3.84 3.32 4.63 5.15 MAMMA1002843 1.72 2.92 2.33 4.09 4.81 3 MAMMA1002844 3.05 3.64 6.52 5.26 7.3 4.09 MAMMA1002845 1.25 1.57 2.45 3.59 3.55 4.67 * + MAMMA1002857 92.1 106.97 208.17 209.17 202.29 249.13 MAMMA1002858 317.94 188.78 378.89 560.7 620.76 724.33 ** + MAMMA1002863 2.17 2.83 6.91 3.51 5.12 3.96 MAMMA1002868 2.73 3.7 6.26 6.35 9.53 10.25 * + MAMMA1002869 5.43 6.83 26.64 22.68 30.03 29.85 MAMMA1002871 0.61 1.7 1.78 1.9 3.8 1.97 MAMMA1002875 1.9 2.59 3.99 4.48 6.35 4.06 MAMMA1002879 8.42 9.2 14.19 22.55 23.63 27.96 ** + MAMMA1002880 1.23 2.02 2.12 1.48 5.42 2.03 MAMMA1002881 1.21 1.43 1.84 3.01 5.43 2.46 MAMMA1002885 0.96 1.59 2.71 2.6 3.26 1.59 MAMMA1002886 2.63 2.52 3.9 6.01 5.37 7.05 ** + MAMMA1002887 1.28 1.83 2.78 2.98 5.14 4.32 * + MAMMA1002890 0.79 1.7 4.05 4.39 4.8 4.01 MAMMA1002892 1.35 2.45 4.98 6.64 6.24 5.84 * + MAMMA1002893 4.52 3.58 5.4 7.6 8.03 8.43 ** + MAMMA1002895 1.43 1.31 3.28 1.81 3.89 1.64 MAMMA1002898 0.53 1.67 4.15 2.69 4.72 1.42 MAMMA1002905 1.32 1.58 2.51 4.1 5.01 3.87 ** + MAMMA1002906 15.12 10.76 15.42 19.47 13.76 15.58 MAMMA1002908 0.99 1.24 4.28 3.53 4.24 4.07 MAMMA1002909 1.92 2.64 5.67 6.82 8.18 6.57 * + MAMMA1002918 2.75 2.69 5.42 5.27 7.26 6.58 MAMMA1002925 92.88 85.77 163.7 127.31 122.97 178.98 MAMMA1002926 6.08 6.31 16.25 16.64 19.48 19.9 MAMMA1002930 1.21 1.59 5.67 4.88 8.91 4.21 MAMMA1002937 4.91 3.87 30.71 40.45 75.17 61.59 * + MAMMA1002938 1.67 1.86 2.42 2.35 3.2 3.56 MAMMA1002941 0.49 1.48 2.78 2.53 3.59 2.24 MAMMA1002947 2.24 2.59 4.55 6 6.8 7.94 * + MAMMA1002964 1.73 2.9 5.91 6.91 7.24 7.16 * + MAMMA1002967 1.94 1.59 2.28 2.9 4.19 2.79 MAMMA1002970 2.72 1.77 6 7.59 7.28 8.96 * + MAMMA1002971 1.52 1.6 2.9 2.51 7.27 3.93 MAMMA1002972 1 1.32 2.95 1.74 4.56 2.12 MAMMA1002973 1.38 2.45 6.73 4.36 6.72 6.78 MAMMA1002979 55.6 60.16 121.72 134.02 101.19 107.19 MAMMA1002982 0.53 1.98 2.28 2.04 3.28 1.9 MAMMA1002987 1.56 2.11 5.56 3.14 5.55 4.14 MAMMA1003003 0.77 2.18 4.78 4.46 6.47 5.08 MAMMA1003004 1.65 1.86 3.7 3.64 3.59 3.16 MAMMA1003007 0.69 1.16 2.73 1.88 3.7 2.32 MAMMA1003011 1.56 1.8 3.67 3.77 5.41 3.94 MAMMA1003013 3.67 5.57 39.41 47.56 59.11 54.29 * + MAMMA1003015 1.16 1.8 2.21 2.54 2.9 2.19 MAMMA1003019 0.6 1.61 2.1 3.12 4.61 2.63 MAMMA1003020 2.96 4.19 5.34 11.31 10.33 10.09 ** + MAMMA1003026 1.29 1.56 2.95 2.66 4.25 2.25 MAMMA1003031 0.61 1.71 5.64 4.13 5.85 5.89 MAMMA1003033 1.34 1.65 4.13 2.84 5.11 3.64 MAMMA1003035 1.66 2.5 5.44 5.12 7.03 4.9 MAMMA1003039 0.95 0.75 3.31 2.15 4.73 2.48 MAMMA1003040 1.38 2.54 5.32 4.57 7.47 7.43 MAMMA1003044 2.36 2.96 6.52 4.29 6.41 5.99 MAMMA1003047 1.82 3.67 7.61 5.74 7.05 7.13 MAMMA1003049 0.47 1.72 2.03 1.08 1.56 1.45 MAMMA1003055 1.24 1.67 4.92 3.77 5.14 3.44 MAMMA1003056 0.9 0.91 1.85 1.22 2.26 1.02 MAMMA1003057 2.53 3.34 6.76 7.25 9.2 5.01 MAMMA1003066 1.65 2.06 4.73 4.1 7.08 5.07 MAMMA1003075 1.11 1.71 3.16 1.85 4.37 2.32 MAMMA1003089 1.69 2.11 7.13 7.85 8.66 7.43 MAMMA1003092 1.25 1.79 3.21 2.62 4.08 1.76 MAMMA1003095 2.27 3.33 5.4 7.24 8.57 5.34 MAMMA1003099 1.88 2.51 4.95 4.09 6.45 4.35 MAMMA1003102 1.33 2.04 2.88 3.2 3.27 2.39 MAMMA1003104 0.64 1.07 3.17 2.15 3.25 1.56 MAMMA1003113 4.22 4.21 6.98 9.22 7.02 7.07 MAMMA1003126 12.93 14.72 20.89 19.28 12 15.63 MAMMA1003127 2.95 3.14 5.91 3.88 6.12 5.19 MAMMA1003131 2.82 3.51 4.86 3.82 5.91 5.88 MAMMA1003135 3.66 4.65 7.61 2.33 4.04 2.64 MAMMA1003140 0.73 2.01 3.59 2.3 3.32 1.89 MAMMA1003146 2.08 2.24 3.89 3.17 5.09 3.3 MAMMA1003150 1.18 1.8 3.01 3.37 4.29 3.45 * + MAMMA1003154 0.54 1.41 2.29 2.21 3.57 2.34 MAMMA1003155 8.08 9.18 20.88 21.41 17.68 20.56 MAMMA1003157 5.94 4.82 6.07 5.18 7.05 7.89 MAMMA1003163 1.74 1.69 4.23 2.55 5.46 3.08 MAMMA1003164 2.94 4.56 6.23 4.08 9.9 8.18 MAMMA1003166 3.62 3.5 5.77 6.24 8.66 6.12 NB9N31000010 2.5 3.88 7.58 9.63 12.26 9.5 * + NB9N31000016 0.73 2.8 5.21 4.04 4.41 3.15 NB9N31000043 8.1 8.88 19.71 12.51 12.3 12.64 NB9N31000045 167.24 153.32 255.96 401.78 320.53 296.06 * + NB9N31000054 7.29 4.42 11.75 11.15 11.87 13.43 NB9N31000076 2.31 1.94 3.51 4.5 6.35 4.44 * + NB9N31000086 2.62 2.65 6.23 3.61 9.71 7.69 NT2RM1000001 2.56 2.45 6.24 5.7 7.05 6.32 NT2RM1000018 3.84 4.69 10.6 6.58 9.09 6.92 NT2RM1000032 1.12 2.64 3.88 2.28 4.92 3.21 NT2RM1000035 1.72 3.68 5.53 5.44 5.21 5.98 NT2RM1000037 1.38 2.98 2.75 2.41 4.15 2.11 NT2RM1000039 3.45 5.13 5.9 6.51 7.26 8.4 * + NT2RM1000042 33.96 32.7 65.25 57.46 67.15 64.39 NT2RM1000055 0.85 1.74 3.34 1.16 3.55 1.16 NT2RM1000059 3.26 3.16 7.66 4.69 5.97 5.78 NT2RM1000062 1.13 1.21 1.9 3.47 4.33 2.46 * + NT2RM1000065 23.8 16.41 34.06 36.15 35.1 51.38 NT2RM1000066 4.13 4.31 8.98 7.23 10.95 9.81 NT2RM1000071 49.63 37.81 86.71 73.04 63.32 84.05 NT2RM1000080 1.37 2.04 3.8 5.1 5.94 4.5 * + NT2RM1000086 4.04 4.65 4.08 5.01 6.23 5.58 * + NT2RM1000092 6.17 6.93 15.76 14.48 25.91 15.13 NT2RM1000118 0.63 1.12 1.22 0.63 1.7 0.44 NT2RM1000119 1.32 2.27 1.96 1.84 3.38 2.99 NT2RM1000121 1.13 1.84 1.76 2.92 3.84 2.78 * + NT2RM1000122 3.5 3.78 7.34 5.5 8.86 9.57 NT2RM1000127 0.69 1.34 1.47 2.14 3.36 3.32 * + NT2RM1000131 0.71 1.7 1.47 1.36 3.02 2.53 NT2RM1000132 3.2 4.88 4.83 6.86 6.46 6.31 * + NT2RM1000153 1.75 1.9 3.68 2.38 4.45 4.84 NT2RM1000184 72.82 77.46 151.91 106.39 163.07 125.55 NT2RM1000186 1.55 1.46 4.32 2.67 4.72 3.94 NT2RM1000187 3.11 1.96 5.16 10.09 9.1 8.78 ** + NT2RM1000199 1.12 1.37 2.11 2.41 3.51 2.72 * + NT2RM1000213 1.32 1.75 2.38 2.66 2.71 2.22 NT2RM1000215 10.95 11.07 17.21 19.51 22.84 15.14 NT2RM1000218 9.72 9.95 23.71 26.94 24.74 29.21 NT2RM1000224 8.8 8.63 15.2 15.51 21.29 17.61 NT2RM1000236 30.38 24.19 61.14 72.86 82.44 71.5 * + NT2RM1000242 0.23 1.17 1.32 0.39 2.27 0.12 NT2RM1000244 1.41 1.48 3.43 6.9 3.69 6.7 * + NT2RM1000252 1.75 1.5 3.4 3.4 3.06 3.18 NT2RM1000256 7.88 5.89 9.46 26.12 29.45 36.8 ** + NT2RM1000257 1.98 3.01 5.09 4.64 6.83 6.65 NT2RM1000260 7.9 7.01 13.32 9.18 12.49 11.77 NT2RM1000269 3.87 2.87 5.12 6.63 9.78 3.87 NT2RM1000271 0.71 0.8 1.87 0.46 2.47 0.51 NT2RM1000272 117.67 92.26 202.95 249.32 333.98 356.74 * + NT2RM1000273 10.03 9.45 20.12 22.32 16.68 15.76 NT2RM1000274 63.11 66.41 123.01 137.14 91.97 104.48 NT2RM1000280 3.95 4.18 8.18 6.71 8.72 7.93 NT2RM1000295 0.49 1 2.2 1.12 3.16 0.87 NT2RM1000300 1.51 1.87 2.78 3.63 5.75 3.09 NT2RM1000304 58.38 98.72 161.87 187.58 185.55 204.78 * + NT2RM1000314 1.8 2.12 3.6 3.84 4.07 4.33 NT2RM1000318 12.6 14.04 20.81 35.01 29.96 29.8 ** + NT2RM1000335 2.76 2.57 4.34 6.29 5.41 4.09 NT2RM1000341 0.46 1.27 1.95 1.41 2.33 0.99 NT2RM1000350 3.04 3.47 5.52 7.32 5.63 6.44 NT2RM1000354 0.55 1.31 1.31 5.43 7.2 5.72 ** + NT2RM1000355 30.24 31.5 56.85 74.62 50.25 61.33 NT2RM1000361 3.63 3.87 7.23 14.39 20.29 18.78 ** + NT2RM1000365 0.58 1.08 1.71 1.27 1.82 0.52 NT2RM1000372 14.99 19.56 30.06 42.71 46.67 45.44 ** + NT2RM1000377 2.04 2.18 9.66 13.38 14.74 13.48 * + NT2RM1000388 0.35 1.57 3.01 2.2 3.8 2.42 NT2RM1000394 0.45 1.31 1.87 1.43 2.72 0.69 NT2RM1000399 0.53 1.57 3.25 1.98 3.2 1.81 NT2RM1000407 1.13 1.52 2.17 1.02 2.7 1.51 NT2RM1000421 0.84 0.57 2.78 1.06 1.77 1.13 NT2RM1000422 20.65 23.31 54.69 87.5 82.91 79.47 * + NT2RM1000430 1.22 1.57 2.01 3.2 3.67 2.95 ** + NT2RM1000462 1.55 2.33 7.32 5.59 7.28 8.16 NT2RM1000499 1.36 2.09 4.74 5 6.16 6.37 * + NT2RM1000512 12.49 13.22 19.22 10.54 14.15 19.84 NT2RM1000519 33.96 37.54 55.78 31.14 29.25 47.55 NT2RM1000527 7.97 8.92 37.68 55.15 60.19 46.68 * + NT2RM1000539 3.45 3.59 12.93 15.52 17.01 18.1 * + NT2RM1000542 0.85 1.05 2.99 1.17 2.35 1.02 NT2RM1000553 3.7 2.42 22.32 42.83 42.96 34.5 * + NT2RM1000555 11.3 11.6 23.97 34.11 29.67 22.76 NT2RM1000558 2.09 5.34 9.74 9.56 16.24 14.29 NT2RM1000563 1.47 2.42 3.36 4.07 5.58 3.95 * + NT2RM1000566 0.88 1.57 3.5 3.62 6.01 2.79 NT2RM1000570 96.92 77.32 137.63 167.35 105.47 174.1 NT2RM1000571 13.21 11.87 22.51 43.87 40.18 28.45 * + NT2RM1000574 0.84 2.15 2.55 2.15 3.07 1.67 NT2RM1000580 1.37 2.18 4.07 5.15 7.98 2.96 NT2RM1000620 2.61 2.95 8.2 8.35 9.58 7.26 NT2RM1000623 1.25 1.2 2.38 1.75 2.81 0.62 NT2RM1000630 0.79 2.28 2.39 1.68 3.51 1.67 NT2RM1000633 30.97 39.36 36.34 54.43 44.6 43.59 * + NT2RM1000634 1.91 4.16 8.12 2.56 7.05 5.57 NT2RM1000642 3.85 5.37 8.13 8.21 8.56 8.52 NT2RM1000647 41.3 39.09 62.11 57.72 68.29 62.69 NT2RM1000648 2.49 2.65 4.61 6.14 5.63 4.51 NT2RM1000650 2.46 3.05 7.6 5.4 6.07 6 NT2RM1000661 4.48 5.7 15.82 15.48 13.45 13.18 NT2RM1000666 1 1.77 1.99 1.37 2.8 0.71 NT2RM1000669 3.51 2.76 4.67 3.63 5.42 3.28 NT2RM1000672 2.23 3.95 7.81 3.98 8.47 7.22 NT2RM1000681 99.53 86.09 118.7 105.41 90.59 124.14 NT2RM1000691 2.02 2.61 5.74 3.61 7.69 3.76 NT2RM1000698 1.11 1.43 4 6.42 6.29 4.11 * + NT2RM1000699 1.85 2.86 3.17 3.67 4.35 4.15 * + NT2RM1000702 3.71 4.64 9.47 9.31 9.72 11.4 NT2RM1000703 11.56 12.36 25.24 26.72 20.42 21.06 NT2RM1000704 24.48 23 32.91 46.54 24.13 40.82 NT2RM1000725 60.92 59.45 88.28 94.89 82.36 105.67 NT2RM1000726 1.85 2.02 5.75 1.97 4.8 4 NT2RM1000731 1.11 2.24 4.98 2.45 3.47 3.43 NT2RM1000741 1.38 1.87 3.16 2.69 4.15 2.9 NT2RM1000742 2.61 4.6 7.41 9.55 10.94 9.84 * + NT2RM1000744 2.1 3.61 7.14 4.05 5.24 5.05 NT2RM1000746 2.25 2.47 2.95 2.22 4.01 3.89 NT2RM1000747 23.34 23.92 46.23 44.66 50.12 55.15 NT2RM1000752 3.83 2.36 4.62 3.95 4.88 3.46 NT2RM1000767 4.14 7.27 35.27 25.27 38.02 28.81 NT2RM1000770 2.97 3.08 6.36 4.71 6.71 5.67 NT2RM1000772 0.76 0.7 1.07 1.34 1.69 0.44 NT2RM1000779 13.03 12.11 42.22 53.91 45.61 66.73 * + NT2RM1000780 1.16 2.9 3.74 3.09 4.32 3.01 NT2RM1000781 1.07 0.98 1.71 2.58 4.4 1.93 NT2RM1000789 5.28 5.15 29.74 29.63 46.72 36.53 NT2RM1000800 2.87 2.63 6.37 5.66 9.57 6.96 NT2RM1000802 2.44 2.99 7.5 4.34 5.47 4.82 NT2RM1000811 1.78 1.6 2.13 2.26 4.96 2.76 NT2RM1000826 6.06 6.36 13.34 14.42 20.73 20.98 * + NT2RM1000829 3.91 2.87 6.39 6.73 8.48 8.41 * + NT2RM1000831 81.54 64.45 185.14 182.43 179.79 197.27 NT2RM1000833 14.58 13.33 42.25 76.74 73.25 67.48 ** + NT2RM1000834 4.06 3.09 6.2 8.49 9.42 10.49 ** + NT2RM1000841 12.34 10.01 21.15 34.98 36.63 30.81 ** + NT2RM1000848 4.79 4.42 6.44 9.36 12.74 10.45 ** + NT2RM1000850 2.66 3.42 13.41 8.55 11.79 9.74 NT2RM1000852 1.34 1.94 3.23 3.01 5.76 2.61 NT2RM1000853 1.19 2.85 2.15 3.11 3.26 3.23 NT2RM1000855 29.27 24.82 45.19 52.48 45.32 58.45 NT2RM1000857 4.63 5 10.67 8.76 11.3 10.76 NT2RM1000858 7.3 7.6 15.86 9.09 11.56 10.93 NT2RM1000867 19.42 15.85 28.1 32.52 35.03 24.06 NT2RM1000874 3.15 2.65 7.03 5.17 9.62 5.31 NT2RM1000882 2.36 1.37 3.71 5.39 9.31 5.45 * + NT2RM1000883 5.21 3.34 7.42 5.18 11.3 7.9 NT2RM1000885 3.86 4.43 9.4 7.59 8.15 9.8 NT2RM1000893 3.15 3.41 8.14 7.73 6.17 8.39 NT2RM1000894 3.29 4.4 6.18 8.14 6.11 6.61 NT2RM1000898 3.72 7.33 10.02 13.4 17.51 12.41 * + NT2RM1000899 1.02 2.22 3.07 3.68 7.49 4.69 NT2RM1000905 11.92 17.41 30.36 37.19 45.16 37.3 * + NT2RM1000910 7.5 8.78 20.16 36.37 36.98 37.5 ** + NT2RM1000914 6.46 7.69 19.74 14.28 17.33 17.77 NT2RM1000919 6.1 3.92 9.91 14.61 17.49 15.37 ** + NT2RM1000921 0.72 1.9 3.69 2.79 4.27 3.32 NT2RM1000922 4.7 6.11 8.09 9.03 5.21 6.36 NT2RM1000924 0.89 3.03 3.04 3.08 2.89 3 NT2RM1000927 1.35 1.78 2.85 3.07 4.72 3.46 NT2RM1000951 7.95 11.33 26.73 32.33 34.46 31.18 * + NT2RM1000956 7.91 6.36 13.35 23.61 27.46 21.91 ** + NT2RM1000960 12.48 10.27 29.06 34.95 37.47 38.96 * + NT2RM1000961 3.28 3.61 7.45 9.44 13.18 8.11 NT2RM1000962 4.14 3.5 8.18 7.59 10.15 9.86 NT2RM1000973 16.71 15.79 29.32 31.15 11.56 27.73 NT2RM1000978 0.57 1.46 1.58 0.95 2.64 0.44 NT2RM1000982 2.34 2.29 3.52 3.57 4.94 4.54 * + NT2RM1000991 1.61 1.78 4.25 3.88 5.56 5.23 NT2RM1000994 6.36 6.16 12.57 16.52 16.64 14.53 * + NT2RM1001002 5.11 6.69 15.34 21.78 22.69 22.28 * + NT2RM1001003 5.42 5.15 11.98 16.24 9.06 8.46 NT2RM1001008 1.4 2.22 2.48 1.83 4.34 4.33 NT2RM1001011 6.29 5.43 7.86 14.4 10.46 14.72 * + NT2RM1001013 2.9 2.75 4.75 8.29 7.96 5.81 * + NT2RM1001017 1 1.82 3.44 3.28 4.86 3.92 NT2RM1001018 65.15 74.45 146.86 134.65 125.46 113.93 NT2RM1001026 1.37 2.64 3.17 2.99 4.61 3.31 NT2RM1001028 0.98 1.73 2.91 1.74 1.89 0.76 NT2RM1001043 4.47 3.64 8.42 11.43 12.7 8.01 NT2RM1001044 2.23 3.17 4.92 5.03 5.51 3.93 NT2RM1001059 1.47 3.72 4.12 4.05 6.11 3.02 NT2RM1001063 4.11 3.29 6.1 4.22 5.64 5.6 NT2RM1001066 0.86 1.85 2.44 2.23 3.99 2.85 NT2RM1001072 1.8 2.8 4.33 1.94 3.74 1.52 NT2RM1001074 1.66 2.38 5.18 5.18 4.19 2.67 NT2RM1001076 1.39 2.2 4.94 3.43 4.42 1.72 NT2RM1001082 1.79 2.6 5.23 5.31 5.92 4.57 NT2RM1001085 1.25 1.65 2.81 1.16 3.27 1.17 NT2RM1001092 3.82 4.2 5.57 9.34 7.94 9.82 ** + NT2RM1001102 1.7 2.3 4.4 2.49 5.94 4.64 NT2RM1001103 4.37 3.88 7.18 6.25 10.28 8.08 NT2RM1001105 1.77 2.02 4.63 2.49 5.11 3.51 NT2RM1001112 2.68 2.66 3.69 3.85 4.75 2.43 NT2RM1001115 1.44 1.57 4.72 3 6.46 3.73 NT2RM1001122 2.84 3.35 7.3 9.43 9.75 9.54 * + NT2RM1001136 0.88 1.41 2.71 2.31 3.87 1.59 NT2RM1001139 3.9 3.7 5.38 5.33 11.18 6.77 NT2RM2000003 2.45 3.33 2.4 4.5 6.29 4.88 * + NT2RM2000006 2.34 2.95 7.25 5.12 7.11 6.24 NT2RM2000010 12.79 13.03 22.58 20.2 17.11 21.83 NT2RM2000013 8.1 9.44 50.36 68.75 95.32 74.36 * + NT2RM2000030 4.8 2.21 23.41 26.33 32.15 28.69 NT2RM2000032 2.76 2.92 8.53 10.01 12.19 10.67 * + NT2RM2000039 3.94 4.67 4.75 6.42 5.78 4.99 NT2RM2000042 3.5 4.9 11.69 17.71 17.4 15.02 * + NT2RM2000092 1 2.38 1.98 1.29 4.69 2.25 NT2RM2000093 8.37 6.63 11.41 9.02 12.23 10.18 NT2RM2000101 9.2 9.94 40 61.09 76.38 69.62 * + NT2RM2000104 6.82 8.02 46.75 51.34 68.83 43.48 NT2RM2000124 1.54 2.23 6.33 7.73 8.84 8.47 * + NT2RM2000155 5.08 3.77 5.8 9.45 11.58 12.51 ** + NT2RM2000191 3.33 5.68 28.62 26.54 34.38 31.6 NT2RM2000192 1.03 1.29 2.45 6.3 4.75 3.83 * + NT2RM2000239 1.92 2.79 3.09 2.85 5.02 3.1 NT2RM2000240 32.78 29.59 74.35 61.15 60.54 61.71 NT2RM2000241 4.49 5.9 6.35 8.24 11.72 6.78 NT2RM2000250 1.29 1.54 4.16 2.09 5.05 2.54 NT2RM2000259 3.06 3.42 3.59 6.38 8.44 6.74 ** + NT2RM2000260 2.53 2.05 3.12 4.23 4.07 5.79 * + NT2RM2000265 0.91 1.55 0.99 1.43 2.4 1.09 NT2RM2000287 4.7 4.23 10.82 10.69 11.54 14.73 NT2RM2000306 12.24 9.36 10.48 23.63 14 20.79 * + NT2RM2000312 19.4 17.81 25.01 38.39 31.27 24.8 NT2RM2000322 1.93 1.82 4.48 3.79 7.05 3.32 NT2RM2000343 7.74 8.38 41.34 63.81 79.6 71.12 * + NT2RM2000359 3.67 2.86 4.95 4.93 9.55 4.72 NT2RM2000362 20.09 18.2 62.29 94.88 111.25 95.66 * + NT2RM2000363 1.08 1.89 2.97 4.2 4.32 3.33 * + NT2RM2000368 2.84 2.4 4.74 6.15 5.98 5.29 * + NT2RM2000371 76.64 65.68 119.32 135.82 125 44.64 NT2RM2000374 1.68 1.92 5.75 3.34 4.8 3.58 NT2RM2000387 8.98 9.83 11.92 20.02 25.18 17.11 * + NT2RM2000393 1.7 1.63 3.75 3.31 7.65 3.28 NT2RM2000395 1.07 1.51 1.98 1.72 4.34 2.23 NT2RM2000402 12.38 11 15.78 25.15 18.31 22.51 * + NT2RM2000405 1.33 1.25 2.2 1.52 3.08 3.16 NT2RM2000407 0.76 1.78 2.49 1.89 2.72 2.89 NT2RM2000410 0.79 1.94 2.23 1.98 2.84 2.09 NT2RM2000420 3.09 2.52 4.43 4.24 4.5 3.26 NT2RM2000422 3.22 2.44 5.81 3.61 6.17 2.87 NT2RM2000423 1.91 1.96 5.69 3.89 7.64 4.18 NT2RM2000452 3.46 3.18 4.31 7.35 8.65 9.57 ** + NT2RM2000469 3.28 3.28 4.44 1.87 2.33 2.46 * - NT2RM2000490 6.03 6.03 9.18 5.55 6.16 6.9 NT2RM2000497 3.29 3.29 4.59 3.15 5.48 2.43 NT2RM2000502 4.69 4.69 10.24 5.87 7.08 7.02 NT2RM2000504 7.37 7.37 12.93 10.83 4.49 11.2 NT2RM2000514 2.75 2.75 6.23 3.11 3.32 3.8 NT2RM2000522 1.9 1.9 3.27 1.94 1.18 1.13 NT2RM2000540 6.02 6.02 9.53 9.12 8.96 8.14 NT2RM2000556 2.09 2.09 2.8 1.24 2.33 0.93 NT2RM2000565 3.35 3.35 6.02 3.27 4.14 3.72 NT2RM2000566 6.59 6.59 15.8 9.09 9.21 9.57 NT2RM2000567 2.16 2.16 5.64 2 5.67 3.82 NT2RM2000569 4.69 4.69 7.93 5.77 8.18 4.7 NT2RM2000577 11.08 11.08 15.39 11.79 14.95 14.48 NT2RM2000581 4.64 4.64 6.49 5.98 7.97 6.85 NT2RM2000582 5.23 5.23 10.34 8.34 9.14 7.19 NT2RM2000588 21.84 21.84 65.91 40.15 44.01 45.21 NT2RM2000589 3.98 3.98 11.35 7.96 7.6 8.64 NT2RM2000594 1.87 1.87 4.38 1.62 2.71 1.92 NT2RM2000599 6.34 6.34 16.12 17.82 14.5 15.44 NT2RM2000609 4.61 4.61 6.77 3.76 5.81 5.48 NT2RM2000612 3.52 3.52 6.4 5.93 7.47 4.55 NT2RM2000622 16.6 16.6 56.24 53.07 75.02 55.48 NT2RM2000623 2.66 2.66 7.1 7.92 6.03 5.58 NT2RM2000624 4.18 4.18 10.6 7.33 14.39 7.56 NT2RM2000632 2.8 2.8 6.73 4.1 6.4 4.73 NT2RM2000635 3.42 3.42 8.09 5.41 6.29 5.31 NT2RM2000636 2.61 2.61 6.28 3.99 4.39 3.72 NT2RM2000639 3.73 3.73 8.26 5.42 7.79 5.99 NT2RM2000649 6.03 6.03 9.69 9.4 9.17 8.05 NT2RM2000658 6.49 6.49 13.18 15.17 14.66 15.83 * + NT2RM2000660 11.45 11.45 18.34 17.03 7.1 20.16 NT2RM2000669 3.6 3.6 6.51 5.28 4.28 6.69 NT2RM2000689 31.07 31.07 59.7 37.03 16.51 70.9 NT2RM2000691 2.09 2.09 5.73 4.83 7.13 4.27 NT2RM2000714 3.41 3.41 10.97 11.46 14.54 11.3 NT2RM2000718 4.08 4.08 7.15 2.88 5.42 4.33 NT2RM2000732 5.38 5.38 14.81 9.49 14.18 8.25 NT2RM2000735 3.72 3.72 6.16 4.27 6.55 6.49 NT2RM2000740 2.26 2.26 6.2 4.27 3.01 3.71 NT2RM2000743 2.26 2.26 7.89 5.65 3.24 3.89 NT2RM2000772 6.43 6.43 8.48 5.24 6.72 9.47 NT2RM2000773 8.17 8.17 19.56 19.18 17.96 18.29 NT2RM2000776 13.96 13.96 17.16 24.24 9.95 26.76 NT2RM2000784 6.64 6.64 8.8 8.74 9.02 10.5 NT2RM2000795 4.35 4.35 13.56 7.44 8.66 10.45 NT2RM2000796 2.27 2.27 4.64 1.71 2.31 1.38 NT2RM2000798 25.81 25.81 160.08 158.19 136.83 188.99 NT2RM2000801 45.09 45.09 161.29 160.44 152.13 189.56 NT2RM2000821 7.53 7.53 12.33 7.37 7.77 11.87 NT2RM2000829 5.76 5.76 13.01 8.05 10.13 11.75 NT2RM2000837 3.29 3.29 7.28 4.27 6.08 4.18 NT2RM2000924 9.96 9.96 36.74 43.24 57.8 35.84 NT2RM2000930 10.64 10.64 18.29 24.45 27.78 28.34 ** + NT2RM2000937 4.35 4.35 8.62 5.08 6.66 6.56 NT2RM2000939 1.12 1.12 2.37 2.67 1.84 1.82 NT2RM2000942 124.8 124.8 253.61 161.4 118.61 210.11 NT2RM2000951 1.01 1.01 2.6 2.13 3.12 1.6 NT2RM2000952 2.53 2.53 5.31 5.98 6.41 6.86 * + NT2RM2000966 19.69 19.69 111.88 95.61 137.32 135.9 NT2RM2000973 23.45 23.45 16.81 39.12 39.51 33.8 ** + NT2RM2000983 10.07 10.07 18.59 30.68 39.13 27.52 * + NT2RM2000984 6.48 6.48 7.71 4.88 5.64 5.26 * - NT2RM2000994 8.27 8.27 16.47 13.2 8.36 21.81 NT2RM2001004 6.01 6.01 48.58 47.51 54.15 46.8 NT2RM2001022 101.09 101.09 350.92 239.63 304.37 490.04 NT2RM2001035 10.75 10.75 24.98 24.17 24.54 34.51 NT2RM2001038 5.77 5.77 9.86 10.48 11.75 7.9 NT2RM2001043 4.45 4.45 10.02 5.1 7.41 6.74 NT2RM2001050 2.71 2.71 6.89 4.72 5.83 4.03 NT2RM2001055 3.78 3.78 5.89 4.24 6.31 4.7 NT2RM2001065 6.17 6.17 15.91 8.51 12.12 14.21 NT2RM2001075 39.81 39.81 188.21 154.65 156.72 168.68 NT2RM2001083 2.23 2.23 5.57 4.01 5.8 3.01 NT2RM2001100 10.38 10.38 93.67 95.8 113.9 97.52 NT2RM2001105 6.34 6.34 8.27 11.35 5.34 11.8 NT2RM2001109 6.81 6.81 9.4 11.88 12.47 14.53 * + NT2RM2001110 7.67 7.67 21.63 21.2 30.71 23.29 NT2RM2001126 6.1 6.1 6.53 5.32 6.44 7.27 NT2RM2001131 5.52 5.52 40.22 21.93 29.37 20.14 NT2RM2001141 1.64 1.64 6.84 7.09 6.4 5.45 NT2RM2001152 1.63 1.63 3.27 4.42 5.77 3.02 NT2RM2001177 3.42 3.42 7.23 10.28 7.25 8.24 NT2RM2001194 2.74 2.74 7.51 6.68 5.77 8.17 NT2RM2001195 3.7 3.7 8.8 6.37 7.13 6.89 NT2RM2001196 5.24 5.24 6.35 5.19 6.46 4.64 NT2RM2001201 14.45 14.45 25.36 20.02 21.68 22.38 NT2RM2001221 4.22 4.22 8.61 11.69 13.61 16.63 * + NT2RM2001238 2.87 2.87 5.65 3.91 3.88 1.96 NT2RM2001243 5.39 5.39 8.98 9.81 6.13 6.53 NT2RM2001244 3.91 3.91 10.63 6.58 9.24 6.41 NT2RM2001247 14.94 14.94 121.59 110.47 140.27 118.79 NT2RM2001256 3.84 3.84 5.23 3.15 3.26 2.96 NT2RM2001269 4.4 4.4 5.98 4.8 5.63 4.74 NT2RM2001278 5.28 5.28 7.37 8.45 8.56 5.35 NT2RM2001291 3.05 3.05 5.18 3.24 4.62 2.9 NT2RM2001294 12.47 12.47 24.39 20.08 15.43 17.81 NT2RM2001295 2.56 2.56 8.82 4.54 4.43 4.99 NT2RM2001302 2.38 2.38 4.55 2.3 4.5 2.81 NT2RM2001306 3.51 3.51 7.62 4.1 4.46 5.14 NT2RM2001312 2.34 2.34 3.72 1.92 2.84 1.68 NT2RM2001319 2.76 2.76 3.93 3.61 5.29 4.11 NT2RM2001324 3.73 3.73 8.29 5.48 4.9 5.71 NT2RM2001345 8.53 8.53 10.01 6.83 11.12 14.14 NT2RM2001360 4.02 4.02 6.36 5.67 5.9 5.46 NT2RM2001370 5.75 5.75 14.53 8.56 9.86 11.69 NT2RM2001391 1.79 1.79 6.07 1.85 5.04 1.65 NT2RM2001393 4.49 4.49 6.39 5.12 7.91 7.14 NT2RM2001420 2.94 2.94 4.61 2.61 3.62 3.14 NT2RM2001423 5.44 5.44 9.53 8.64 11.95 11.36 NT2RM2001424 5.88 5.88 15.09 11.77 10.31 11.63 NT2RM2001482 2.24 2.24 6.48 3.5 6.06 3.63 NT2RM2001499 1.4 1.4 5.81 2.84 4.3 2.17 NT2RM2001504 3.63 3.63 6.99 3.2 4.54 1.68 NT2RM2001524 2.51 2.51 5.81 2.34 2.22 3.51 NT2RM2001530 2.56 2.56 4.42 2.68 4.35 3.52 NT2RM2001533 5.06 5.06 9.09 8.2 9.18 7.84 NT2RM2001540 5.77 5.77 8.36 14.57 17.99 27.1 * + NT2RM2001544 2.4 2.4 6.12 3.7 3.72 2.31 NT2RM2001547 6.6 6.6 15.29 8.44 7.61 8.24 NT2RM2001558 1.53 1.53 3.44 1.76 4.87 1.71 NT2RM2001575 2.45 2.45 4.57 3.36 4.38 2.29 NT2RM2001582 2.99 2.99 4.98 2.2 5.16 3.06 NT2RM2001588 3.69 3.69 8.8 6.39 9.14 6.6 NT2RM2001592 2.66 2.66 6.2 3.1 5.24 4.64 NT2RM2001603 4.74 4.74 8.7 10.42 12.03 11.77 * + NT2RM2001605 1.74 1.74 4.52 3.08 1.51 2.39 NT2RM2001611 2.28 2.28 8.63 3.74 3.34 3.51 NT2RM2001613 14.91 14.91 32.53 21.51 13.13 27.42 NT2RM2001626 2.45 2.45 3.08 2.1 4.28 2.06 NT2RM2001632 4.93 4.93 7.07 4.67 4.88 5.42 NT2RM2001633 4.45 4.45 10.39 3.74 5.15 5.43 NT2RM2001635 4.33 4.33 9.54 4.3 5.81 4.7 NT2RM2001636 4.88 4.88 7.35 12.75 18.11 13.34 ** + NT2RM2001637 1.25 1.25 6.48 4.18 3.68 2.51 NT2RM2001639 3.98 3.98 9.32 4.67 4.33 3.29 NT2RM2001641 1.63 1.63 4.69 4.84 6.02 2.71 NT2RM2001643 2.78 2.78 7.46 4.79 4.4 2.83 NT2RM2001648 12.97 12.97 18.91 20.13 17.07 25.5 NT2RM2001652 6.32 6.32 5.65 4.29 8.13 4.46 NT2RM2001659 5.78 5.78 9.17 5.73 5.28 6.95 NT2RM2001660 3.44 3.44 3.86 2.08 2.29 2.63 ** - NT2RM2001664 1.24 1.24 6.12 4.51 4.89 4.8 NT2RM2001668 3.72 3.72 8.16 7.66 5.72 7.02 NT2RM2001670 1.62 1.62 4.11 2.88 3.96 3.56 NT2RM2001671 2.67 2.67 5.57 3.9 6.46 4.85 NT2RM2001675 1.94 1.94 4.28 1.97 3.73 0.64 NT2RM2001681 2.47 2.47 5.91 3.13 4.64 3.39 NT2RM2001685 4.58 4.58 5.68 1.29 2.72 1.14 ** - NT2RM2001688 5.46 5.46 4.14 3.11 3.82 2.46 * - NT2RM2001695 15.09 15.09 35.18 17.41 19.26 34.51 NT2RM2001696 2.74 2.74 6.64 7.15 6.7 6.8 NT2RM2001698 1.44 1.44 3 4.06 3.49 1.65 NT2RM2001699 1.63 1.63 5.03 4.19 3.75 5.48 NT2RM2001700 1.65 1.65 4.13 2.56 3.37 3.91 NT2RM2001704 2.68 2.68 5.46 3.89 3.85 3.99 NT2RM2001706 4.29 4.29 6.77 3.33 3.13 3.32 NT2RM2001714 6.48 6.48 6.64 5.62 7.33 5.18 NT2RM2001716 0.97 0.97 3.7 3.03 5.49 2.92 NT2RM2001718 1.91 1.91 3.47 5 3.5 3 NT2RM2001723 2.09 2.09 5.48 5.1 5.21 5.71 NT2RM2001727 3.08 3.08 6.25 7.51 7.28 5.7 NT2RM2001730 3.52 3.52 7.15 5.04 5.43 3.85 NT2RM2001738 4.56 4.56 6.2 6.71 10.25 9.08 * + NT2RM2001743 2.95 2.95 5.81 4.39 5.02 4.46 NT2RM2001753 5.98 5.98 7.55 5.72 6.09 4.54 NT2RM2001755 0.89 0.89 2.82 2.4 2.83 2.67 NT2RM2001760 14.77 14.77 33.17 27.49 25.48 36.23 NT2RM2001765 1.35 1.35 1.71 2.45 3.12 2.03 * + NT2RM2001767 12.04 12.04 120.66 148.84 168.4 146.29 * + NT2RM2001768 2.1 2.1 3.59 3.41 4.21 3.05 NT2RM2001771 4.82 4.82 5.65 7.15 5.97 5.05 NT2RM2001778 2.89 2.89 4.09 2.34 3.24 1.48 NT2RM2001782 5.32 5.32 7.32 4.96 7.71 7.57 NT2RM2001784 0.84 0.84 2.19 2.81 2.5 1.41 NT2RM2001785 1.35 1.35 4.11 5.5 5.02 2.76 NT2RM2001792 6.03 6.03 8.53 5.49 5.54 5.76 NT2RM2001795 3.97 3.97 6.15 7.62 5.96 8.9 NT2RM2001797 2.82 2.82 3.78 5 5.94 2.71 NT2RM2001800 3.46 3.46 4.26 5.01 4.03 5.24 NT2RM2001803 3.5 3.5 6.61 4.46 7.34 2.44 NT2RM2001805 3.65 3.65 3.21 2.53 4.2 1.71 NT2RM2001806 7.34 7.34 17.96 15.62 15.23 21.11 NT2RM2001813 1.54 1.54 2.05 2.54 1.88 2.32 NT2RM2001814 2.46 2.46 4.71 3.52 2.89 4.42 NT2RM2001818 1.21 1.21 2.66 0.97 1.48 0.27 NT2RM2001823 1.4 1.4 3.24 1.87 2.46 1.37 NT2RM2001825 14.79 14.79 36.08 34.68 34.2 35.81 NT2RM2001832 5.93 5.93 6.1 5.19 5.48 2.93 NT2RM2001839 67.48 67.48 123.46 152.63 157.11 121.35 NT2RM2001840 3.04 3.04 7.13 4.61 5.11 5.37 NT2RM2001851 3.92 3.92 7.61 3.78 4.74 6.49 NT2RM2001855 8.21 8.21 11.51 10.22 12.06 15.41 NT2RM2001867 2.82 2.82 5.01 2.83 5.62 3.74 NT2RM2001869 60.8 60.8 90.58 101.19 79.67 105.32 NT2RM2001879 3.01 3.01 6.99 2.55 3.19 2.66 NT2RM2001883 1.52 1.52 3.26 0.98 2.28 0.73 NT2RM2001886 1.57 1.57 4.56 2.48 3.51 2.42 NT2RM2001887 3.78 3.78 7.66 4.48 4.97 5.73 NT2RM2001896 274.2 274.2 378.57 325.68 216.52 497.31 NT2RM2001902 1.92 1.92 4.28 1.31 2.92 2.14 NT2RM2001903 16.25 16.25 42.55 35.47 31.71 37.22 NT2RM2001930 2.11 2.11 6.3 2.3 5.86 5.44 NT2RM2001935 4.16 4.16 5.04 3.16 4.42 5.87 NT2RM2001936 2.81 2.81 4.9 2.99 3.44 4 NT2RM2001939 3.56 3.56 3.34 1.82 3.01 3.16 NT2RM2001941 1.84 1.84 4.29 2.84 2.82 2.72 NT2RM2001950 4.66 4.66 10 6.01 6 8.69 NT2RM2001952 2.67 2.67 4.78 2.49 4.55 5.37 NT2RM2001976 11.48 11.48 18.2 14.58 11.46 35.27 NT2RM2001982 1.85 1.85 3.91 2.04 2.47 1.88 NT2RM2001983 4.45 4.45 8.36 4.18 6.49 7.54 NT2RM2001984 7.74 7.74 8.88 20.06 27.05 22.95 ** + NT2RM2001989 2.72 2.72 3.68 2.99 4.26 3.7 NT2RM2001996 7.51 7.51 8.09 4.8 8.01 5.29 NT2RM2001997 3.65 3.65 7.29 3.18 5.09 6.78 NT2RM2001998 2.24 2.24 5.07 3.33 6.53 3.96 NT2RM2001999 4.86 4.86 7.69 6.88 6.02 4.01 NT2RM2002003 11.33 11.33 18.17 10.15 11 14.9 NT2RM2002004 1.99 1.99 5.79 2.51 2.09 1.9 NT2RM2002009 5.35 5.35 9.03 9.85 11.04 11.09 * + NT2RM2002014 2.62 2.62 3 3.65 4.47 4.03 ** + NT2RM2002019 25.1 25.1 38.52 19.47 14.2 16.35 NT2RM2002029 12.92 12.92 19.01 10.82 4.88 14.74 NT2RM2002030 4.15 4.15 5.8 13.54 9.71 21.98 * + NT2RM2002034 22.05 22.05 31.76 24.83 20.89 21.04 NT2RM2002049 7.4 7.4 12.12 9.76 10.42 13.22 NT2RM2002055 2.8 2.8 8.01 1.91 4.03 2.52 NT2RM2002072 9.26 9.26 12.88 12.28 19.12 12.82 NT2RM2002088 4.82 4.82 13.85 11.35 11.7 15.28 NT2RM2002091 4.98 4.98 8.44 5.92 3.82 4.61 NT2RM2002100 3.26 3.26 6.05 4.82 4.24 3.19 NT2RM2002109 1.31 1.31 3.57 2.57 4.88 4.92 NT2RM2002126 21.41 21.41 32.24 35.28 22.31 31.52 NT2RM2002128 3.7 3.7 5.17 2.74 3.86 2.41 NT2RM2002129 6.43 6.43 11.48 8.53 13.03 10.66 NT2RM2002142 5.72 5.72 9.74 5.26 8.91 6.4 NT2RM2002144 3.27 3.27 3.76 1.85 1.73 1.62 ** - NT2RM2002145 2.63 2.63 8.69 6.1 5.18 5.98 NT2RM2002153 2.61 2.61 6.37 6.31 7.62 5.75 NT2RM2002163 0.97 0.97 3.41 1.87 3.4 0.64 NT2RM2002170 3.28 3.28 7.03 6.62 7.5 7.65 NT2RM2002178 3.99 3.99 3.67 3.5 5.48 2.9 NT2RM2002179 7.82 7.82 8.69 6.17 8.15 6.02 NT2RM2002270 4.51 4.51 4.56 2.28 1.76 1.67 ** - NT2RM2002326 2.47 2.47 3.86 2.13 3.69 2.34 NT2RM2002337 1.88 1.88 3.97 5.4 4.22 4.79 * + NT2RM2002339 2.83 2.83 6.29 5.26 5.22 3.85 NT2RM2002345 5.16 5.16 6.03 4.04 4.2 4.21 * - NT2RM2002368 2.43 2.43 5.86 6.05 7.01 4.96 NT2RM2002381 2.23 2.23 5.16 3.47 3.65 2.8 NT2RM2002424 4.64 4.64 7.1 6.69 8.5 6.3 NT2RM2002450 4.17 4.17 3.87 2.29 2.39 1.87 ** - NT2RM2002482 3.93 3.93 4.65 2.66 3.2 3.79 NT2RM2002492 9.39 9.39 24.31 29.13 24.65 29.29 NT2RM2002575 3.26 3.26 5.23 5.99 6.03 5.07 NT2RM2002580 4.23 4.23 4.68 4.82 7.79 7.42 NT2RM2002592 7.7 7.7 12.59 13.07 15.28 14.69 * + NT2RM2002608 27.33 27.33 45.49 57.07 65.96 48.3 * + NT2RM2002615 6.01 6.01 9.38 13.15 20.32 14.42 * + NT2RM2002622 14.35 14.35 16.22 18.38 24.99 13.44 NT2RM2002630 4.86 4.86 6.63 8.05 7.37 6.7 NT2RM2002634 1.72 1.72 4.66 4.71 4.6 3.94 NT2RM2002645 27.02 27.02 68.46 30.66 14.59 31.46 NT2RM2002646 12.09 12.09 25.03 29.45 22.88 34.8 NT2RM2002647 7.68 7.68 17.56 19.5 17.74 23.44 NT2RM2002652 5.11 5.11 4.71 4.3 6.43 3.73 NT2RM2002692 4.59 4.59 4.48 2.5 2.86 2.02 ** - NT2RM2002721 30.26 30.26 46.01 62.71 84.18 61.02 * + NT2RM2002748 18.37 18.37 43.62 87.35 119.27 102.35 ** + NT2RM2002764 2.28 2.28 5.3 5.05 5.95 4.07 NT2RM2002772 3.15 3.15 9.32 9.66 7.81 5.44 NT2RM2002811 5.79 5.79 12.3 14.01 9.18 10.45 NT2RM2002818 2.03 2.03 7.94 5.86 5.42 7.13 NT2RM2002879 4.21 4.21 7.17 8.39 7.87 9.11 * + NT2RM2002979 11.79 11.79 19.66 24.49 23.23 21.79 * + NT2RM2002981 4.42 4.42 3.78 3.58 4.95 2.63 NT2RM2002995 5.13 5.13 3.29 3.42 3.74 3.5 NT2RM2003031 1.37 1.37 2.63 3 2.58 1.9 NT2RM2003042 4.1 4.1 10.77 10.59 6.02 6.07 NT2RM2003044 1.88 1.88 4.11 2.13 5.11 1.2 NT2RM2003090 4.4 4.4 7.64 9.36 7.91 10.68 * + NT2RM2003095 11.98 11.98 25.25 15.63 16.43 19.04 NT2RM2003116 11.16 11.16 16.09 17.96 21.43 22.08 * + NT2RM2003222 3.98 3.98 3.63 2.67 3.64 2.35 NT2RM2003224 11.29 11.29 15.33 24.29 29.77 20.76 * + NT2RM2003250 14.18 14.18 86.06 85.79 96.6 94.15 NT2RM2003258 4.59 4.59 6.32 6.54 5.11 5.69 NT2RM2003262 5.07 5.07 7.33 5.06 7.76 5.72 NT2RM4000023 2.15 2.15 7.02 3.57 4.91 4.29 NT2RM4000024 2.28 2.28 6.78 3.17 4.98 4.33 NT2RM4000027 4.74 4.74 7.77 4.85 6.94 11.32 NT2RM4000030 2.95 2.95 5.73 3.16 4.9 2.64 NT2RM4000033 2.51 2.51 4.77 2.36 3.89 4.61 NT2RM4000034 1.93 1.93 5.35 3.74 4.84 6.09 NT2RM4000046 1.37 1.37 3.79 1.57 3.5 2.32 NT2RM4000052 1.82 1.82 3.55 1.72 2.96 1.98 NT2RM4000054 10.43 10.43 13.85 12.07 12.83 24.7 NT2RM4000061 1.65 1.65 4.17 1.66 4.54 0.83 NT2RM4000074 15.83 15.83 43.57 27.9 34.24 30.79 NT2RM4000085 5.35 5.35 10.1 8.41 10.19 10.17 NT2RM4000086 3.06 3.06 4.5 3.84 5.25 3.71 NT2RM4000100 6.62 6.62 15.05 12.74 15.6 14.84 NT2RM4000101 3.77 3.77 9.11 7.17 7.71 8.78 NT2RM4000102 32.35 32.35 42.47 27.24 19.34 70.54 NT2RM4000104 2.78 2.78 7.13 3.41 5.12 4.3 NT2RM4000115 2.87 2.87 6.1 3.91 5.86 4.08 NT2RM4000129 2.17 2.17 4.75 2.62 3.48 2.18 NT2RM4000139 3.17 3.17 3.31 3.58 4.82 6.49 NT2RM4000149 2.74 2.74 1.49 2.41 2.55 7.32 NT2RM4000155 2.73 2.73 5.5 2.13 4.51 3.71 NT2RM4000156 5.94 5.94 16.74 20.45 21 21.96 * + NT2RM4000167 1.36 1.36 2.58 2.61 4.34 1.75 NT2RM4000169 9.95 9.95 36.53 29.12 24.89 23.57 NT2RM4000191 4.29 4.29 7.56 5.49 5.57 5.66 NT2RM4000197 2.73 2.73 4.78 1.83 3.86 2.2 NT2RM4000198 3.38 3.38 7.42 5.26 5.45 4.21 NT2RM4000199 2 2 3.51 2.8 4 3.76 NT2RM4000200 0.67 0.67 3.19 2.25 1.84 1.2 NT2RM4000202 1 1 3.24 2.11 2.42 1.84 NT2RM4000210 1.46 1.46 3.72 2.41 3.08 2.21 NT2RM4000215 2.54 2.54 5.43 3.3 4.09 3.06 NT2RM4000220 6.42 6.42 10.52 8.68 11.08 15.14 NT2RM4000229 3.26 3.26 6.62 1.46 2.34 1.76 NT2RM4000231 6.37 6.37 7.06 6.13 7.85 6.24 NT2RM4000233 4.83 4.83 17.3 11.9 14.34 13.4 NT2RM4000244 2.35 2.35 5.22 3.86 4.14 5.17 NT2RM4000251 3.85 3.85 10.97 4.82 6.52 4.59 NT2RM4000255 2.28 2.28 4.7 3.79 4.89 1.42 NT2RM4000265 2.23 2.23 5.69 4.29 8.21 1.99 NT2RM4000283 18.14 18.14 26.21 37.17 39.88 44.79 ** + NT2RM4000284 13.85 13.85 33.72 31.96 42.88 40.67 NT2RM4000290 6.31 6.31 7.76 3.77 4.92 4 * - NT2RM4000295 2.36 2.36 2.16 2.32 2.13 0.88 NT2RM4000306 3.79 3.79 7.76 7.1 6.14 5.02 NT2RM4000307 5.04 5.04 9.13 9.95 9.99 11.72 * + NT2RM4000309 2.48 2.48 5.34 3.92 6.52 5.52 NT2RM4000313 3.92 3.92 9.61 5.75 7.77 8.52 NT2RM4000318 3.38 3.38 6.87 4.35 6.36 3.28 NT2RM4000324 4.93 4.93 5.93 2.79 4.98 2.12 NT2RM4000326 5.32 5.32 4.61 2.59 2.45 2.01 ** - NT2RM4000327 4.97 4.97 10.95 7.94 10.32 7.71 NT2RM4000344 5.46 5.46 16.67 11.16 10.17 19.18 NT2RM4000349 3.68 3.68 9.99 11.87 10.88 13.8 * + NT2RM4000354 1.65 1.65 3.13 4.2 4.31 3.1 NT2RM4000356 1.5 1.5 3.11 2.5 4.07 1.64 NT2RM4000366 15.75 15.75 44.48 38.81 44.07 58.06 NT2RM4000368 3.04 3.04 5.9 4.36 5.48 3.48 NT2RM4000373 6.49 6.49 12.29 12.72 15.96 16.47 * + NT2RM4000386 4.92 4.92 4.71 3.81 4.57 4.6 NT2RM4000395 2.7 2.7 4.69 6.36 6.51 5.68 * + NT2RM4000414 1 1 2.76 2.38 2.9 2.19 NT2RM4000417 1.66 1.66 2.83 3.9 3.95 3.25 * + NT2RM4000421 2.99 2.99 5.17 4.96 5.47 4.13 NT2RM4000425 10.56 10.56 26.8 26.49 31.48 45.28 NT2RM4000433 2.78 2.78 5.39 1.67 2.21 1.79 NT2RM4000436 3.8 3.8 9.47 11.84 16.75 16.38 * + NT2RM4000444 4.51 4.51 12.97 7.29 8.54 7.38 NT2RM4000457 3.35 3.35 8.69 13.35 12.38 13.25 * + NT2RM4000471 1.73 1.73 4.01 4.17 4.87 2.49 NT2RM4000472 2.2 2.2 7.62 6.64 7.61 5.39 NT2RM4000486 2.98 2.98 5.92 6.85 7.54 6 NT2RM4000490 3.85 3.85 6.41 7.16 5.1 5.86 NT2RM4000496 3.68 3.68 3.86 2.16 2.36 2.04 ** - NT2RM4000505 26.85 26.85 60.33 68.9 80.59 70.67 * + NT2RM4000511 22.8 22.8 45.35 64.6 89.95 75.97 * + NT2RM4000514 2.61 2.61 6.75 10.47 7.53 9.25 * + NT2RM4000515 3.75 3.75 8.81 7.27 7.94 4.66 NT2RM4000517 34.51 34.51 74.2 76.45 53.07 79.47 NT2RM4000520 2.24 2.24 3.08 3.21 3.3 5.49 NT2RM4000531 2.76 2.76 5.71 4.41 5.5 4.22 NT2RM4000532 3.03 3.03 5.56 2.72 3.54 2.39 NT2RM4000533 3.55 3.55 5.43 4.73 6.98 3.23 NT2RM4000534 5.17 5.17 2.92 2.73 4.62 1.94 NT2RM4000563 5.21 5.21 16.69 17.05 16.8 19.36 NT2RM4000566 1.79 1.79 4.6 7.14 5.27 7.91 * + NT2RM4000568 10.48 10.48 19.4 28.18 22.91 33.06 * + NT2RM4000585 1.97 1.97 2.52 0.82 1.99 1.26 NT2RM4000587 3.88 3.88 6.15 6.66 5.75 5.15 NT2RM4000590 3.73 3.73 4.12 1.64 2.48 2.3 ** - NT2RM4000593 4.46 4.46 7.83 10.21 12.36 7.45 NT2RM4000595 3.94 3.94 3.91 2.27 4.36 2.45 NT2RM4000603 4.18 4.18 6.98 6.95 7.23 7.26 NT2RM4000611 9.81 9.81 18.02 17.1 17.38 25.49 NT2RM4000616 2.05 2.05 6.19 2.73 4.14 4.53 NT2RM4000621 26.04 26.04 70.86 57.5 62.2 59.07 NT2RM4000648 2.78 2.78 7.83 2.66 2.67 3.88 NT2RM4000649 5.53 5.53 11.03 7.34 8.4 13.12 NT2RM4000658 3.22 3.22 8.18 4.22 6.14 8.14 NT2RM4000661 57.68 57.68 140.68 141.09 135.49 177.49 NT2RM4000673 3.02 3.02 5.72 3.69 3.8 4.59 NT2RM4000674 2.23 2.23 4.27 2.89 2.63 2.99 NT2RM4000689 3.81 3.81 6.47 5.34 6.36 7.74 NT2RM4000698 14.85 14.85 20.92 25.12 23.66 26.39 * + NT2RM4000700 2.39 2.39 5.53 2.41 6.95 5.61 NT2RM4000701 10.07 10.07 54.36 61.81 67.75 63.17 NT2RM4000712 3.5 3.5 7.9 5.97 8.03 9.55 NT2RM4000717 2.14 2.14 6.66 3.67 2.94 4.3 NT2RM4000733 4.37 4.37 7.8 4.16 6.93 11.03 NT2RM4000734 2.17 2.17 5.92 2.35 5.23 4.7 NT2RM4000741 2.14 2.14 6.11 3.59 4.75 4.66 NT2RM4000744 1.76 1.76 7.05 2.76 4.4 10.18 NT2RM4000749 15.53 15.53 23.13 26.26 27.8 34.67 * + NT2RM4000751 2.88 2.88 6.54 6.23 6.11 5.94 NT2RM4000752 4.11 4.11 4.88 4.78 5.12 38.58 NT2RM4000760 3.5 3.5 9.69 4.54 6.31 5.26 NT2RM4000761 237.9 237.9 478.3 219.65 302.54 336.34 NT2RM4000764 66.05 66.05 178 212.33 205.98 232.75 * + NT2RM4000768 6.11 6.11 11.21 15.56 10.14 21.17 NT2RM4000778 1.6 1.6 4.7 4.27 5.18 6.18 NT2RM4000779 4.52 4.52 8.28 6.87 7.19 7.33 NT2RM4000787 2.55 2.55 7.49 3.64 4.9 4.53 NT2RM4000790 2.99 2.99 5.03 5.47 5.82 12.06 NT2RM4000795 1.99 1.99 3.67 2.36 1.2 2.51 NT2RM4000796 3.26 3.26 5.86 4.29 3.48 4.28 NT2RM4000798 1.77 1.77 5.53 3.72 3.08 3.47 NT2RM4000800 4.15 4.15 8.16 8.7 9.44 9.06 NT2RM4000813 3.31 3.31 8.79 7.14 7.95 10.09 NT2RM4000820 4.89 4.89 9.14 5.39 6.27 5.44 NT2RM4000827 7.1 7.1 18.55 16.3 15.8 17.88 NT2RM4000830 3.27 3.27 7.35 5.28 7.8 8.38 NT2RM4000833 2.51 2.51 6.84 4.48 3.35 4.87 NT2RM4000841 4 4 15 10.57 8.84 10.1 NT2RM4000846 1.66 1.66 8.83 4.74 6.83 5.09 NT2RM4000848 2.61 2.61 5.75 4.15 6.32 3.12 NT2RM4000852 3.89 3.89 9.81 8.16 8.67 8.29 NT2RM4000855 5.12 5.12 7.64 5.99 6.08 7.19 NT2RM4000859 11.18 11.18 16.28 16.48 19.12 17.62 NT2RM4000868 3.06 3.06 6.47 5.23 6.91 7.05 NT2RM4000870 4 4 9.82 7.06 3.87 6.59 NT2RM4000879 1.67 1.67 6 4.15 3.31 3.11 NT2RM4000882 18.99 18.99 28.36 20.33 16.5 12.55 NT2RM4000887 2.16 2.16 6.01 3.53 4.91 1.6 NT2RM4000895 2.33 2.33 5.33 3.16 5.9 3.08 NT2RM4000897 5.78 5.78 6.99 8.89 9.73 7.02 NT2RM4000901 5.22 5.22 6.41 4.37 6.2 6.12 NT2RM4000950 4.04 4.04 5.09 3.57 4.06 2.91 NT2RM4000965 2.89 2.89 4.54 5.98 4.04 6.18 NT2RM4000971 2.49 2.49 4.78 4.84 4.29 7.62 NT2RM4000979 5.16 5.16 12.71 10.23 10.46 7.87 NT2RM4000987 1.9 1.9 4.59 3.64 4.22 3.21 NT2RM4000989 2.51 2.51 5.17 4.2 5.16 4.99 NT2RM4000991 3.1 3.1 4.83 2.87 3.53 8.73 NT2RM4000992 3.39 3.39 5.41 3.6 4.54 3.19 NT2RM4000996 6.22 6.22 7.86 7.14 8 7.28 NT2RM4000997 3.53 3.53 13.96 9.81 10.96 10.89 NT2RM4001001 26.06 26.06 55.43 37.67 34.22 54.29 NT2RM4001002 5.13 5.13 11.03 11.54 11.33 19.44 NT2RM4001016 1.63 1.63 2.73 4.07 5.31 3.76 * + NT2RM4001025 65.77 65.77 133.97 148.39 181.87 171.5 * + NT2RM4001027 2.49 2.49 3.66 1.67 1.77 4.31 NT2RM4001032 2.55 2.55 6.74 4.94 5.46 3.84 NT2RM4001047 3.87 3.87 3.7 2.61 2.73 2.7 ** - NT2RM4001049 3.97 3.97 10.12 18.29 20.63 26.25 ** + NT2RM4001051 2.72 2.72 12.54 11.17 10.12 13.68 NT2RM4001052 14.95 14.95 72.14 75.49 75.01 79.12 NT2RM4001053 14.96 14.96 39.3 41.36 28.95 25.87 NT2RM4001054 3.13 3.13 5.17 5.34 5.69 5.01 NT2RM4001059 3.65 3.65 6.37 4.91 3.52 4.48 NT2RM4001071 4.03 4.03 7.35 6.8 7.34 6.55 NT2RM4001084 8.04 8.04 6.52 9.49 10.53 9.53 * + NT2RM4001092 12.61 12.61 109.97 76.93 98.78 73.14 NT2RM4001100 6.72 6.72 20.93 22.35 15.18 18.98 NT2RM4001116 1.17 1.17 2.5 2.77 2.96 2.16 NT2RM4001119 1.74 1.74 4.82 4.72 4.22 4.15 NT2RM4001140 2.65 2.65 7.49 8.27 7.78 9.03 NT2RM4001148 6.59 6.59 13.68 12.1 12.92 15.83 NT2RM4001151 3.7 3.7 4.31 1.94 3.65 1.68 NT2RM4001155 5.51 5.51 6.36 3.55 5.37 4.63 NT2RM4001157 1.68 1.68 4.95 4.86 2.81 3.82 NT2RM4001160 1.57 1.57 3.39 2.99 1.9 2.41 NT2RM4001163 42.35 42.35 86.27 106.63 52.13 98.56 NT2RM4001187 2.64 2.64 7.25 3.96 4.87 5.2 NT2RM4001191 3.2 3.2 9.95 8.59 6.36 8.72 NT2RM4001200 3.83 3.83 6.35 5.52 4.41 4.11 NT2RM4001203 9.93 9.93 20.29 22.65 25.36 21.82 NT2RM4001204 3.23 3.23 3.59 3.17 2.83 2.6 NT2RM4001217 4.62 4.62 12.16 11.26 13.39 13.72 NT2RM4001245 7.31 7.31 17.14 13.76 14.49 17.16 NT2RM4001247 3.23 3.23 9.1 5.73 6.57 5.03 NT2RM4001256 2.51 2.51 6.39 3.57 5.48 4.14 NT2RM4001258 8.2 8.2 24.68 25.02 24.16 22.89 NT2RM4001267 3.43 3.43 4.83 3.93 4.3 8.08 NT2RM4001273 4.23 4.23 8.38 7.39 6.96 8.77 NT2RM4001281 4 4 10.54 10.15 9.05 10 NT2RM4001286 345.27 345.27 526.77 215.2 220.51 552.53 NT2RM4001290 23.51 23.51 61.5 56.51 48.6 59.58 NT2RM4001309 2.64 2.64 6.81 3.17 5.42 4.05 NT2RM4001313 2.63 2.63 8.62 3.81 6.36 7.03 NT2RM4001316 3.14 3.14 6.12 3.39 3.85 5.25 NT2RM4001320 2.4 2.4 6.43 2.83 3.16 5.6 NT2RM4001321 3.98 3.98 8.62 6.17 7.03 6.24 NT2RM4001325 2.54 2.54 5.2 4.76 2.93 5.25 NT2RM4001333 8.65 8.65 18.06 8.57 10.76 9.51 NT2RM4001340 4.81 4.81 12.27 6.99 7.72 11.24 NT2RM4001344 4.09 4.09 4.69 3.04 3.44 4.93 NT2RM4001347 6.49 6.49 9.8 10.53 9.72 17.71 NT2RM4001357 7.59 7.59 12.09 8.58 11.68 9.37 NT2RM4001360 2.79 2.79 5.11 3.82 2.85 3.07 NT2RM4001371 4.71 4.71 8.57 6.58 13.16 12.93 NT2RM4001377 8.01 8.01 13.74 8.66 9.23 10.58 NT2RM4001382 17.31 17.31 56.74 35.57 28.32 38.22 NT2RM4001384 2.17 2.17 4.11 2.35 3.34 3.75 NT2RM4001400 3.78 3.78 5.76 4.87 4.66 5.07 NT2RM4001409 2.55 2.55 6.82 4.82 4.63 5.27 NT2RM4001410 5.48 5.48 21.69 17.34 21.09 18.91 NT2RM4001411 2.66 2.66 6.5 5.86 6.64 6.77 NT2RM4001412 1.75 1.75 3.33 2.39 2.52 2.79 NT2RM4001414 2.18 2.18 4.83 2.45 2.4 3.77 NT2RM4001436 8.35 8.35 16.65 10.45 10.13 15.55 NT2RM4001437 2.77 2.77 8.85 8.31 11.26 7.67 NT2RM4001444 11.57 11.57 25.93 21.1 18.36 18.42 NT2RM4001454 3.62 3.62 7.89 6.16 5.03 4.79 NT2RM4001455 5.85 5.85 22.19 18.03 25.08 26.16 NT2RM4001483 4.37 4.37 8.77 4.97 5.43 6.46 NT2RM4001489 3.12 3.12 7.04 3.64 4.19 5.46 NT2RM4001495 1.35 1.35 5.13 2.85 3.29 3.37 NT2RM4001499 1.74 1.74 4.98 3.65 2.77 3.3 NT2RM4001515 0.95 0.95 3.38 2.65 5.38 3.41 NT2RM4001519 1.86 1.86 4.6 2.24 4.38 2.85 NT2RM4001522 3.8 3.8 7.66 5.36 7.42 9.13 NT2RM4001523 5.46 5.46 9.11 4.82 7.58 5.79 NT2RM4001550 11.9 11.9 17.38 16.49 16.76 15.01 NT2RM4001553 7.88 7.88 13.4 23.26 23.53 23.87 ** + NT2RM4001554 0.86 0.86 1.74 1.85 1.11 2.2 NT2RM4001557 2.5 2.5 6.33 5.05 3.36 4.89 NT2RM4001565 1.87 1.87 4.05 2.46 3.34 3.23 NT2RM4001566 3.23 3.23 8.57 8.91 10.49 11.42 NT2RM4001569 1.47 1.47 5.4 3.35 4.15 1.56 NT2RM4001579 6.57 6.57 16.69 19.23 23.83 18.22 NT2RM4001582 4.06 4.06 5.97 2.16 3.17 2.67 * - NT2RM4001589 21.51 21.51 37.16 42.45 55.76 47.57 * + NT2RM4001592 1.37 1.37 2.96 3.02 2.14 3.71 NT2RM4001594 1.98 1.98 4.09 5.4 5.24 5.67 * + NT2RM4001597 2.65 2.65 5.64 5.17 4.97 4.33 NT2RM4001605 2.7 2.7 6.18 5.71 5.92 5.93 NT2RM4001609 23.65 23.65 45 61.08 78.89 77.31 * + NT2RM4001610 48.1 48.1 69.16 132.54 132.39 115.22 ** + NT2RM4001611 3.31 3.31 4.56 2.33 2.32 2.02 * - NT2RM4001618 7.05 7.05 7.95 6.68 8.98 12.95 NT2RM4001622 13.53 13.53 19.88 14.67 24.67 28.46 NT2RM4001624 1.6 1.6 3.02 3.92 2.66 4.43 NT2RM4001625 4.89 4.89 39.6 41.63 47.1 46.46 NT2RM4001629 3.82 3.82 8.82 12.09 12.08 13.38 * + NT2RM4001632 15.28 15.28 24.55 31.07 26.16 25.6 NT2RM4001642 3.29 3.29 4.17 2.89 3.62 2.1 NT2RM4001647 4.44 4.44 6.83 4.04 5.48 4.67 NT2RM4001650 4.96 4.96 4.94 2.66 2.87 3.79 ** - NT2RM4001662 2.18 2.18 5.47 8.31 6.54 9.39 * + NT2RM4001666 2.28 2.28 6.5 6.24 6.17 8.14 NT2RM4001670 3.52 3.52 10.77 11.16 10.82 14.91 NT2RM4001682 12.66 12.66 31.6 33.03 26.04 37.07 NT2RM4001710 6.7 6.7 38.5 40.58 58.41 40.31 NT2RM4001712 4.06 4.06 7.61 10.19 10.7 9.98 * + NT2RM4001714 10.88 10.88 19.37 18.67 19.3 17.65 NT2RM4001715 10.77 10.77 11.6 13.55 16.86 12.99 NT2RM4001727 3.41 3.41 5.92 4.83 5.89 7.6 NT2RM4001731 2.6 2.6 10.72 13.46 11.23 11.73 NT2RM4001735 12.84 12.84 21.53 22.01 20.88 34.93 NT2RM4001739 2.46 2.46 7.3 8.13 5.17 7.14 NT2RM4001741 14.41 14.41 29.88 26.98 27.21 32.35 NT2RM4001746 3.65 3.65 6.76 6.89 6.5 5.33 NT2RM4001754 3.16 3.16 4.17 3.39 3.62 3.84 NT2RM4001757 5.02 5.02 5.78 4.7 6.31 7.97 NT2RM4001758 1 1 0.76 1.98 0.65 1.46 NT2RM4001768 4.83 4.83 10.19 8.48 6.91 7.83 NT2RM4001775 3.23 3.23 2.76 1.9 1.85 1.71 ** - NT2RM4001776 2.56 2.56 4.77 2.47 2.68 2.69 NT2RM4001783 2.88 2.88 3.22 3.12 3.48 3.68 NT2RM4001793 4.67 4.67 11.44 12.02 9.6 10.75 NT2RM4001810 3.31 3.31 4.46 3.33 3.63 3.11 NT2RM4001813 3.9 3.9 4.15 4.71 4.19 5.36 NT2RM4001818 4.06 4.06 11.34 10.43 8.67 10.53 NT2RM4001819 2.35 2.35 5.6 2.37 3.02 4.58 NT2RM4001823 1.76 1.76 4.48 2.47 4.04 4.27 NT2RM4001828 5.01 5.01 11.49 5.67 7.54 7.51 NT2RM4001835 9.75 9.75 18.65 21.12 16.5 26.55 NT2RM4001836 3.27 3.27 8.32 3.65 3.54 5.58 NT2RM4001841 7.94 7.94 15.82 20.15 20.96 23.33 * + NT2RM4001842 2.1 2.1 4.44 3.5 3.35 4.85 NT2RM4001843 5.65 5.65 14.54 13.34 12.25 14.94 NT2RM4001856 4.42 4.42 7.16 7.65 4.71 16.83 NT2RM4001858 5.91 5.91 15.86 16.09 17.03 16.93 NT2RM4001861 2.91 2.91 9.57 6.31 8.66 9.28 NT2RM4001863 8.06 8.06 9.5 15.16 15.68 11.77 * + NT2RM4001865 5.04 5.04 11.25 7.44 10.24 9.03 NT2RM4001869 5.1 5.1 5.96 5.22 8.45 21.88 NT2RM4001873 9.62 9.62 18.43 13.33 15.49 19.21 NT2RM4001876 2.24 2.24 6.94 3.65 4.39 7.25 NT2RM4001880 3.6 3.6 8.57 5.13 5.41 7.67 NT2RM4001885 5.71 5.71 11.11 7.11 6.56 11.98 NT2RM4001889 10.25 10.25 18.24 16.31 15.85 21.33 NT2RM4001894 2.61 2.61 6.07 3.58 3.65 3.49 NT2RM4001897 7.87 7.87 20.24 18.41 20.4 23.46 NT2RM4001899 3.36 3.36 7.43 4.92 8.19 8.54 NT2RM4001905 3 3 4.84 3.3 4.53 7.1 NT2RM4001922 2.55 2.55 6.05 3.97 4.84 5.11 NT2RM4001930 2.64 2.64 8.9 2.88 6.53 6.38 NT2RM4001938 2.65 2.65 4.91 5.09 5.65 6.43 NT2RM4001940 2.73 2.73 6.17 5.91 4.46 5.48 NT2RM4001942 37.36 37.36 32.02 53.86 59.28 82.77 * + NT2RM4001953 4.65 4.65 9.68 5.04 6.79 4.91 NT2RM4001965 4.96 4.96 8.82 10.18 8.54 8.39 NT2RM4001966 3 3 5.14 6.3 7.45 8.19 * + NT2RM4001969 2.22 2.22 7.29 5.01 2.95 4.5 NT2RM4001974 1.19 1.19 4.61 1.89 2.96 4.83 NT2RM4001979 2.09 2.09 6.37 3.39 4.65 7.36 NT2RM4001980 4.3 4.3 7.59 7.58 8.02 9.33 NT2RM4001984 2.31 2.31 5.36 2.68 3.49 4.57 NT2RM4001987 3.36 3.36 9.66 2.92 4.6 5.01 NT2RM4002013 6.62 6.62 15.13 13.47 17.16 19.8 NT2RM4002018 2.31 2.31 5.15 4.09 5.53 7.1 NT2RM4002033 3.19 3.19 8.16 4.91 3.27 5.93 NT2RM4002034 1.89 1.89 6.19 4.82 4.38 4.03 NT2RM4002044 7.71 7.71 17.9 18.75 12.3 18.5 NT2RM4002047 3.88 3.88 5.19 2.68 5.38 9.2 NT2RM4002054 4.54 4.54 6.97 2.56 4.3 3.89 NT2RM4002055 13.72 13.72 74.75 60.51 91.27 61.53 NT2RM4002059 23.73 23.73 31.85 48.05 63.09 52.61 ** + NT2RM4002061 3.72 3.72 5.32 3.59 3.69 4.81 NT2RM4002062 1.9 1.9 5.41 3.66 2.84 4.26 NT2RM4002063 2.21 2.21 8.1 7.64 7.35 3.79 NT2RM4002066 2.07 2.07 5.29 4.42 6.32 4.07 NT2RM4002067 2.51 2.51 4.27 3.07 5.19 4.41 NT2RM4002073 3.73 3.73 7.24 5.51 7.69 5.16 NT2RM4002074 5.19 5.19 7.35 5.67 7.47 4.49 NT2RM4002075 5.13 5.13 5.9 3.16 3.18 2.91 ** - NT2RM4002076 3.13 3.13 3.05 1.94 2.52 1.71 * - NT2RM4002078 10.3 10.3 28.06 23.95 20.81 26.64 NT2RM4002081 10.47 10.47 30.87 19.18 17.8 18.22 NT2RM4002082 1.25 1.25 3.02 3.85 2.58 1.23 NT2RM4002093 2.82 2.82 3.9 4.79 4.66 4.79 * + NT2RM4002109 4.42 4.42 11.51 13.95 15.12 15.21 * + NT2RM4002115 2.86 2.86 4.51 4.81 4.8 2.52 NT2RM4002118 4.48 4.48 6.14 4.3 4.86 4.27 NT2RM4002128 3.78 3.78 4.57 2.84 3.31 3.13 * - NT2RM4002137 3.96 3.96 8.14 10.27 7.51 8.92 NT2RM4002139 3.78 3.78 8.98 7.03 7.84 7.87 NT2RM4002140 4.04 4.04 9.45 8.87 7.81 10.17 NT2RM4002145 5.99 5.99 17.51 25.81 31.07 24.47 * + NT2RM4002146 4.51 4.51 8.23 8.56 9 8.92 NT2RM4002161 2.33 2.33 4.97 1.38 3.15 5.3 NT2RM4002174 4.86 4.86 8.02 3.12 4.53 6.15 NT2RM4002178 7.3 7.3 24.43 28.61 33.13 29.27 * + NT2RM4002180 3.47 3.47 11.93 9.27 10.02 11.28 NT2RM4002185 5.94 5.94 35.51 31.59 32.34 31.69 NT2RM4002189 1.6 1.6 3.24 3.68 5.59 4.91 * + NT2RM4002194 9.3 9.3 25.94 37.2 29.64 38.23 * + NT2RM4002198 6.09 6.09 7.61 9.37 8.4 10.04 * + NT2RM4002205 4.01 4.01 9.05 6.76 7.86 8.76 NT2RM4002213 5.36 5.36 8.79 8.05 11.99 14.41 NT2RM4002216 7.35 7.35 12.58 16.58 23.93 18.16 * + NT2RM4002226 3.84 3.84 9.71 20.85 16.65 16.5 ** + NT2RM4002237 4.19 4.19 10.13 10.37 7.64 13.22 NT2RM4002240 1.96 1.96 3.64 3.73 3.71 7.59 NT2RM4002251 2.11 2.11 6.2 7.87 5.48 5.17 NT2RM4002256 4.38 4.38 10.68 10.7 9.46 9.64 NT2RM4002262 2.85 2.85 6.25 3.34 4.43 9.66 NT2RM4002266 3.93 3.93 4.76 2.76 3.55 4.47 NT2RM4002276 11.23 11.23 15.55 16.5 28.25 20.64 NT2RM4002278 1.89 1.89 4.59 4.33 3.99 5.11 NT2RM4002281 17.71 17.71 59.08 62.68 51.19 59.89 NT2RM4002287 2.08 2.08 3.84 2.46 4.21 3.32 NT2RM4002294 3.19 3.19 6.99 6.28 6.09 8.69 NT2RM4002298 18.59 18.59 60.14 86.09 89.9 88.75 * + NT2RM4002301 3.2 3.2 6.85 4.63 5.94 4.02 NT2RM4002306 4.71 4.71 8.24 4.99 5.31 4.2 NT2RM4002323 3.9 3.9 4.06 4.11 4.39 3.11 NT2RM4002334 11.54 11.54 20.76 17.92 20.72 16.95 NT2RM4002339 1.78 1.78 3.52 1.33 1.3 1.38 NT2RM4002344 2.36 2.36 5.74 2.87 3.57 7.92 NT2RM4002345 3.56 3.56 10.59 5.06 4.63 7.5 NT2RM4002352 2.04 2.04 7.67 3.99 5.14 3.74 NT2RM4002362 20.38 20.38 24.92 11.23 14.32 15.17 * - NT2RM4002373 2.1 2.1 3.96 3.21 2.55 3.63 NT2RM4002374 2.28 2.28 4.39 2.29 3.58 4.3 NT2RM4002376 4.02 4.02 6.03 3.31 2.97 5.52 NT2RM4002383 2.8 2.8 8.49 4.76 5.79 4.28 NT2RM4002390 3.03 3.03 6.01 4.06 5.27 7.37 NT2RM4002398 5.16 5.16 43.18 33.97 50.73 30.41 NT2RM4002409 2.11 2.11 5.93 3.37 4.29 1.9 NT2RM4002414 4.73 4.73 6.21 7.37 9.12 14.53 NT2RM4002438 2.07 2.07 5.28 3.03 4.38 7.18 NT2RM4002440 2.99 2.99 6.92 5.78 5.32 9.49 NT2RM4002446 2.23 2.23 6.08 2.95 4.45 5.7 NT2RM4002450 3.36 3.36 10.01 6.15 7.75 7.24 NT2RM4002452 2.13 2.13 6.3 3.67 5.15 7.23 NT2RM4002457 2.68 2.68 4.44 2.66 3.26 4.52 NT2RM4002458 3.06 3.06 5.77 3.32 5.34 4.04 NT2RM4002460 2.43 2.43 3.68 1.57 2.45 1.43 NT2RM4002464 5.4 5.4 12.62 14.39 13.72 14.3 NT2RM4002479 4.66 4.66 6.69 4.91 7.98 11.54 NT2RM4002482 4.26 4.26 16.18 10.19 11.5 12.2 NT2RM4002489 6.74 6.74 16.91 8.79 5.81 11.68 NT2RM4002493 1.35 1.35 3.22 1.96 3.51 2.73 NT2RM4002499 34.96 34.96 72.9 59.42 52.07 54.3 NT2RM4002504 5.15 5.15 10.68 10.57 13.51 9.8 NT2RM4002506 4.77 4.77 9.4 4.93 7.59 8.53 NT2RM4002510 2.03 2.03 3.27 1.66 2.97 2.48 NT2RM4002527 1.57 1.57 3.14 1.83 2.31 4.47 NT2RM4002532 2.45 2.45 7.75 5.88 3.37 5.19 NT2RM4002534 1.79 1.79 4.8 2.1 3.45 2.94 NT2RM4002535 2.5 2.5 6.51 5.89 8.1 6.37 NT2RM4002554 3.29 3.29 5.31 3.31 5.47 3.12 NT2RM4002558 6.91 6.91 32.57 32.58 41.54 25.61 NT2RM4002565 5.38 5.38 13.6 8.22 9.85 10.53 NT2RM4002567 3.34 3.34 5.43 4.21 4.49 7.22 NT2RM4002571 4.48 4.48 15.61 11.95 16.47 15.24 NT2RM4002572 5.57 5.57 17.2 13.7 9.59 13.48 NT2RM4002577 7.76 7.76 15.25 6.59 5.87 5.65 NT2RM4002583 1.08 1.08 3.58 2.28 4.83 2.44 NT2RM4002584 1.64 1.64 5.67 3.24 5.74 5.56 NT2RM4002593 3.29 3.29 5.17 2.75 3.91 4.61 NT2RM4002594 11.26 11.26 46.5 38.21 55.32 43.58 NT2RM4002604 4.83 4.83 4.64 1.77 2.03 2.89 ** - NT2RM4002614 3.48 3.48 3.48 2.52 3.66 2.81 NT2RM4002616 1.07 1.07 2.73 2.88 2.71 2.38 NT2RM4002623 1.39 1.39 4.89 3.92 3.72 5.06 NT2RM4002634 1.41 1.41 4.38 3.42 4.91 2.96 NT2RM4002636 2.22 2.22 3.93 3.92 4.18 4.12 NT2RP1000002 8.82 8.82 52.94 75.1 92.89 81.45 * + NT2RP1000006 4.68 4.68 6.28 4.25 4.48 2.56 NT2RP1000015 4.86 4.86 5.27 2.74 1.99 2.28 ** - NT2RP1000018 5.45 5.45 5 5.55 4.83 4.96 NT2RP1000034 18.22 18.22 49.95 38.04 30.76 50.07 NT2RP1000035 1.93 1.93 3.2 5.26 3.23 3.96 NT2RP1000040 1.77 1.77 3.33 2.93 3.28 4.28 NT2RP1000042 1.3 1.3 3.44 1.99 3.22 2.38 NT2RP1000048 3.6 3.6 10.24 7.25 9.9 9 NT2RP1000050 2.21 2.21 4.71 2.89 4 3.57 NT2RP1000056 4.03 4.03 3.74 1.09 0.61 1.96 ** - NT2RP1000058 3.49 3.49 2.03 1.84 2.07 2.48 NT2RP1000063 1.77 1.77 3.65 4.09 4 3.83 NT2RP1000068 1.89 1.89 3.99 3.12 3.33 2.43 NT2RP1000072 22.9 22.9 74.07 82.91 66.26 95.85 NT2RP1000073 2.18 2.18 2.45 2.68 3.69 3.86 * + NT2RP1000078 2.72 2.72 3.17 2.93 2.3 3.13 NT2RP1000079 4.13 4.13 5.32 3.6 4.48 2.5 NT2RP1000080 4.99 4.99 8.13 9.46 12.46 9.46 * + NT2RP1000086 4.15 4.15 3.63 1.31 2.1 3.75 NT2RP1000087 1.3 1.3 4.36 3.51 3.21 3.45 NT2RP1000089 4.5 4.5 9.98 12.69 11.3 14.93 * + NT2RP1000090 45.76 45.76 96.6 94.37 53.44 93.42 NT2RP1000100 2.17 2.17 4.05 5.23 4.13 3.66 NT2RP1000101 3.44 3.44 5.22 4.41 2.88 4.81 NT2RP1000111 3.24 3.24 5.56 4.51 3.9 3.69 NT2RP1000112 3.29 3.29 4.08 1.85 3.33 3 NT2RP1000124 5.57 5.57 4.96 3.11 5.73 5.5 NT2RP1000125 7.28 7.28 19.39 13.69 10.68 16.86 NT2RP1000129 1.81 1.81 4.35 5.14 3.91 4.27 NT2RP1000130 2.31 2.31 4.11 5.31 5.62 16.86 NT2RP1000154 7.5 7.5 15.63 17.16 12.72 16.37 NT2RP1000163 2.42 2.42 3.51 2.72 2.99 3.59 NT2RP1000170 3.42 3.42 4.2 4.96 5.17 5.85 * + NT2RP1000174 3.5 3.5 3.42 1.3 2.38 2.12 ** - NT2RP1000181 6.14 6.14 7.22 10.97 14.98 9.38 * + NT2RP1000191 1.08 1.08 5.61 4.94 3.59 5.71 NT2RP1000202 1.06 1.06 1.66 2.02 1.2 2.24 NT2RP1000239 1.53 1.53 4.1 2.15 0.94 2.07 NT2RP1000243 2.37 2.37 2.04 1.31 1.14 1.64 ** - NT2RP1000255 1.94 1.94 3.02 2.11 2.26 1.78 NT2RP1000259 5.27 5.27 9.55 5.53 6.33 4.29 NT2RP1000261 2.76 2.76 4.4 2.07 1.64 2.64 NT2RP1000269 5.16 5.16 5.01 7.7 10.51 7.39 * + NT2RP1000271 7.79 7.79 15.88 13.16 15.11 18.48 NT2RP1000272 7.71 7.71 13.07 10.72 11.74 11.3 NT2RP1000279 2.19 2.19 5.24 2.23 3.91 2.62 NT2RP1000290 6.61 6.61 9.02 12.65 13.52 9.92 * + NT2RP1000293 6.86 6.86 10.91 9.75 8.45 10.92 NT2RP1000300 12.42 12.42 11.93 9.96 11.37 10.2 * - NT2RP1000324 5.16 5.16 6 4.69 5.92 6.97 NT2RP1000325 54.42 54.42 101.4 70.46 57.52 78.6 NT2RP1000326 4.01 4.01 7.67 3.82 4.56 7.85 NT2RP1000331 12.16 12.16 24.08 12.19 10.5 20.1 NT2RP1000333 4.18 4.18 7.52 6.66 6.53 6.98 NT2RP1000336 1.45 1.45 4.45 1.35 3.76 1.78 NT2RP1000347 3.05 3.05 8.75 7.26 8.31 6.38 NT2RP1000348 2.11 2.11 4.14 2.76 3 2.75 NT2RP1000349 2.12 2.12 3.92 3 4.39 4.11 NT2RP1000353 40.87 40.87 83.5 51.49 47.8 66.02 NT2RP1000356 39.53 39.53 93.37 50.3 56.48 74.42 NT2RP1000357 3.89 3.89 9.63 8.43 8.7 8.72 NT2RP1000358 2.85 2.85 6.11 4.23 3.04 5.09 NT2RP1000360 11.04 11.04 19.39 12.08 18.42 19.44 NT2RP1000363 13.09 13.09 15.39 13.13 13.38 10.01 NT2RP1000376 1.81 1.81 3.8 2.09 1.9 2.24 NT2RP1000386 118 118 191.31 146.98 187.97 155.47 NT2RP1000407 0.72 0.72 3.16 0.58 0.89 1.2 NT2RP1000409 2.05 2.05 5.39 2.84 6.59 3.83 NT2RP1000413 4.78 4.78 8.03 5.86 8.89 10.19 NT2RP1000416 1.5 1.5 2.01 0.93 3.17 0.7 NT2RP1000418 2.27 2.27 6.69 5.08 6.67 4.85 NT2RP1000420 1.77 1.77 5.19 7.32 7.64 3.7 NT2RP1000434 1.48 1.48 4.39 1.27 3.12 1 NT2RP1000439 5.02 5.02 9.31 20.62 28.73 24.75 ** + NT2RP1000443 1.8 1.8 3.46 2.24 1.61 1.63 NT2RP1000447 2.21 2.21 5.57 2.49 2.87 3.1 NT2RP1000448 1.39 1.39 3.58 3.09 4.4 1.41 NT2RP1000451 4.2 4.2 6.37 5.72 7.27 7.04 NT2RP1000458 15.1 15.1 10.53 19.73 8.72 23.03 NT2RP1000460 7.55 7.55 13.82 8.76 11.49 8.62 NT2RP1000465 4.58 4.58 20.97 20.41 19.98 22.46 NT2RP1000468 3.25 3.25 4.64 3.82 4.1 4.45 NT2RP1000470 2.38 2.38 5.67 3.99 2.35 3.8 NT2RP1000477 1.11 1.11 3.81 1.1 0.84 0.83 NT2RP1000478 4.53 4.53 12.55 19.87 18.75 20.39 * + NT2RP1000481 1.23 1.23 3.89 2.48 4.09 1.2 NT2RP1000493 2.44 2.44 3.8 1.74 3.83 0.87 NT2RP1000513 13.07 13.07 16.37 17.06 17.57 18.97 * + NT2RP1000522 6.13 6.13 12.69 13.13 13.08 10.32 NT2RP1000533 3.72 3.72 6.17 2.92 4.49 2.17 NT2RP1000544 1.53 1.53 2.45 1.38 1.24 1.44 NT2RP1000547 0.88 0.88 2.45 2 1.63 1.23 NT2RP1000551 1.7 1.7 2.62 2.13 3.2 1.1 NT2RP1000567 1.66 1.66 4.29 2.54 4.29 1.77 NT2RP1000574 1.99 1.99 4.28 1.5 3.43 1.38 NT2RP1000577 3.14 3.14 6.01 3.16 5.31 2.05 NT2RP1000579 4.64 4.64 6.24 3.27 3.97 2.04 NT2RP1000581 5.22 5.22 3.58 2.07 1.61 0.93 ** - NT2RP1000593 1.74 1.74 4.39 2.48 3.28 2.3 NT2RP1000604 3.85 3.85 7.75 17.25 13.78 16.39 ** + NT2RP1000609 1.15 1.15 2.21 2.84 2.61 1.55 NT2RP1000613 1.12 1.12 2.56 1.82 4.29 0.82 NT2RP1000622 5.94 5.94 15.9 14.91 19.42 15.46 NT2RP1000627 9.18 9.18 18.96 23.88 21.9 14.86 NT2RP1000629 4.18 4.18 5.9 5.92 5.32 3.17 NT2RP1000630 6.54 6.54 7.84 7.21 7.67 7.92 NT2RP1000639 0.64 0.64 0.31 1.53 2.04 0.28 NT2RP1000640 130.14 130.14 307.77 227.5 176.05 232.29 NT2RP1000646 4.14 4.14 9.59 10.19 11.87 12.15 * + NT2RP1000659 2.65 2.65 7 8.91 7.99 6.04 NT2RP1000674 13.48 13.48 28.08 43.62 45.82 56.95 ** + NT2RP1000677 3.9 3.9 10.76 11.84 10.19 9.87 NT2RP1000679 2.38 2.38 3.76 2.3 2.35 1.05 NT2RP1000688 4.72 4.72 3.34 2.76 2.73 1.83 * - NT2RP1000689 1.44 1.44 1.86 2.03 1.22 1.13 NT2RP1000695 1.11 1.11 2.5 2.09 2.44 1.52 NT2RP1000701 0.89 0.89 1.08 2.62 2.74 1.71 * + NT2RP1000702 1.12 1.12 2.28 3.74 4.07 3.15 * + NT2RP1000713 2.29 2.29 2.79 2.8 3.56 2.38 NT2RP1000721 4.14 4.14 4.49 4.48 3.92 3.78 NT2RP1000730 3.5 3.5 4.83 2.61 4.5 2.41 NT2RP1000733 6.08 6.08 6.56 4.91 8.12 5.65 NT2RP1000738 3.18 3.18 8.04 5.16 5.71 7.11 NT2RP1000739 1.11 1.11 2.65 4.02 3.09 2.86 NT2RP1000740 1.41 1.41 3.13 3.63 3.57 3.77 * + NT2RP1000746 1.15 1.15 3.58 2.28 3.74 1.37 NT2RP1000750 4 4 8.31 10.25 10.72 9.39 * + NT2RP1000751 33.15 33.15 59.65 67.84 64.22 66.55 NT2RP1000767 3.8 3.8 3.64 1.7 2.62 0.62 * - NT2RP1000769 9.31 9.31 13.98 7.42 8.59 7.19 NT2RP1000780 0.86 0.86 1.01 1.87 1.13 0.89 NT2RP1000782 4.25 4.25 12.21 10.24 7.96 9.13 NT2RP1000796 3.17 3.17 2.69 4.23 2.99 2.86 NT2RP1000797 12.31 12.31 22.78 19.44 18.64 21.78 NT2RP1000800 1.13 1.13 3.74 2.46 2.66 1.46 NT2RP1000825 2.38 2.38 2.91 1.04 1.88 0.87 * - NT2RP1000833 2.5 2.5 2.85 0.92 2.39 1.26 NT2RP1000834 35.44 35.44 66.57 73.98 90.28 71.45 NT2RP1000836 1.83 1.83 3.43 1.01 2.39 1.04 NT2RP1000837 3.36 3.36 6.66 3.22 4.71 3.67 NT2RP1000846 1.29 1.29 5.48 1.67 2.84 1.4 NT2RP1000847 1.99 1.99 5.49 2.15 5.12 1.64 NT2RP1000851 4.67 4.67 9.32 6.18 7.94 6.72 NT2RP1000856 14.31 14.31 17.46 20.38 23.22 19.37 * + NT2RP1000860 2.09 2.09 4.54 4.02 2.74 4.04 NT2RP1000902 5.31 5.31 11.6 6.94 9.91 7.34 NT2RP1000903 2.45 2.45 6.26 4.04 3.42 4.24 NT2RP1000905 1.76 1.76 4.87 5.36 5.66 10 NT2RP1000915 5.51 5.51 10.01 6.72 8.59 9.91 NT2RP1000916 2.31 2.31 5.51 1.78 3.82 2.09 NT2RP1000921 9.38 9.38 8.73 8.23 9.13 7.92 NT2RP1000943 5.14 5.14 10.76 8.51 8.55 7.2 NT2RP1000944 1.59 1.59 2.21 1.78 1.74 1.15 NT2RP1000947 8.5 8.5 14.91 16.51 15.04 14.22 NT2RP1000954 2.11 2.11 4.96 2.74 5.55 3.04 NT2RP1000958 6.48 6.48 14.73 4.54 10.17 10.21 NT2RP1000959 124.81 124.81 209.45 128.43 72.65 206.1 NT2RP1000966 9.96 9.96 12.96 14.28 15.36 21.39 NT2RP1000974 2.46 2.46 5.38 3.98 6.08 3.71 NT2RP1000980 3.07 3.07 5.5 4.04 4.53 4.02 NT2RP1000981 4.3 4.3 8.09 5.68 7.26 5.27 NT2RP1000988 6.45 6.45 10.46 9.62 6.44 7.87 NT2RP1001002 2.8 2.8 7.36 3.94 4.57 4.3 NT2RP1001004 4.72 4.72 8.25 3.65 4.9 5.37 NT2RP1001007 1.42 1.42 3.42 1.69 3.84 2.03 NT2RP1001011 1.94 1.94 5.93 3.82 5.46 4.83 NT2RP1001013 4.45 4.45 9.41 5.92 8.62 5.04 NT2RP1001014 2.21 2.21 5.89 3.76 6.64 3.49 NT2RP1001020 1.87 1.87 4.11 2.08 3.75 2.36 NT2RP1001023 62.79 62.79 145.09 101.48 105.86 143.96 NT2RP1001027 18.11 18.11 82.66 51.63 59.05 68.9 NT2RP1001031 1.83 1.83 3.31 2.05 3.53 2.25 NT2RP1001033 2.43 2.43 6.09 5.68 5.98 4.27 NT2RP1001042 2.94 2.94 6.47 2.99 3.85 2.04 NT2RP1001045 15.95 15.95 23.24 40.66 47.04 44.53 ** + NT2RP1001073 6.64 6.64 10.57 8.32 10.46 7.33 NT2RP1001079 2.91 2.91 6.37 2.16 2.58 1.48 NT2RP1001080 2.16 2.16 4.89 6.88 4.2 4.56 NT2RP1001113 1.07 1.07 3.64 3.55 3.94 3.26 NT2RP1001159 21.42 21.42 43.84 22.89 23.31 34.25 NT2RP1001173 1.7 1.7 3.07 1.38 4.28 1.52 NT2RP1001176 7.4 7.4 10.13 13 9.31 13.95 NT2RP1001177 5.31 5.31 5.75 3.01 5.5 2.02 NT2RP1001185 6.42 6.42 9.37 3.79 4.63 2.73 * - NT2RP1001199 3.9 3.9 7.67 6.93 5.22 3.28 NT2RP1001205 7.78 7.78 19.46 16.66 12.64 23.28 NT2RP1001215 1.82 1.82 5.02 3.79 4.12 3.15 NT2RP1001225 4.54 4.54 7.96 7.56 8.77 6.31 NT2RP1001245 7.27 7.27 10.86 19.68 21.03 22.13 ** + NT2RP1001247 2.04 2.04 4.01 1.77 2.89 1.67 NT2RP1001248 2.81 2.81 6.79 3.94 4.63 2.4 NT2RP1001253 5.02 5.02 6.39 4.48 4.38 3.32 NT2RP1001286 6.18 6.18 7.69 3.79 3.88 4.12 ** - NT2RP1001294 2.4 2.4 4.47 3.6 2.73 4.18 NT2RP1001302 2.46 2.46 4.51 4.89 2.9 5.39 NT2RP1001310 15.54 15.54 34.01 21.13 20.75 27.15 NT2RP1001311 1.9 1.9 3.22 2.66 3.16 2.38 NT2RP1001313 2.6 2.6 7.72 5.45 7.85 5.78 NT2RP1001324 2.47 2.47 5.3 3.34 4.17 2.35 NT2RP1001349 3.3 3.3 6.29 3.63 3.92 2.14 NT2RP1001361 19.41 19.41 18.28 23.28 28.33 24.16 * + NT2RP1001379 3.82 3.82 9.52 4.97 7.97 7.06 NT2RP1001385 2.06 2.06 4.51 4.09 3.89 4.4 NT2RP1001395 4.96 4.96 7.86 6.01 6.32 8.13 NT2RP1001410 8.75 8.75 20.39 15.74 15.66 9.94 NT2RP1001424 2.39 2.39 3.34 3 3 1.73 NT2RP1001432 4.33 4.33 3.86 2.19 1.76 2.05 ** - NT2RP1001449 6.23 6.23 7.5 6.29 8.21 4.63 NT2RP1001457 4.09 4.09 4.21 2.11 2.26 2.63 ** - NT2RP1001459 21.54 21.54 132.97 90.96 107.97 81.08 NT2RP1001466 5.73 5.73 14.97 11.31 9.39 10.99 NT2RP1001475 2.45 2.45 6.31 5.98 6.67 3.9 NT2RP1001482 3.93 3.93 9.18 15.88 13.03 8.2 NT2RP1001494 1.61 1.61 4.6 4.34 4.18 2.25 NT2RP1001500 3.39 3.39 8.13 8.09 8.65 7.42 NT2RP1001517 5.11 5.11 7.37 4.41 5.38 2.36 NT2RP1001540 4.74 4.74 5.03 4.6 4.86 3.11 NT2RP1001543 1.02 1.02 1.83 1.49 1.12 0.98 NT2RP1001546 22.51 22.51 51.51 34.99 22.76 33.42 NT2RP1001550 9.33 9.33 21.4 14.35 12.21 13.42 NT2RP1001553 2.07 2.07 6.07 5.69 6.04 4.45 NT2RP1001555 36.28 36.28 58.55 41.1 53.63 54.35 NT2RP1001563 2.28 2.28 3.44 2.07 2.24 1.31 NT2RP1001569 9.43 9.43 16 17.31 18.21 13.04 NT2RP1001584 15.6 15.6 19.66 28.1 32.53 25.83 ** + NT2RP1001599 1.18 1.18 1.95 1.27 1.19 1.24 NT2RP1001616 5 5 11.95 9.49 6.7 8.95 NT2RP1001654 11.78 11.78 18.07 16.27 16.54 18.38 NT2RP1001665 2.77 2.77 4.72 2.73 2.05 2.05 NT2RP1001679 76.31 76.31 195.7 199.2 240.87 222.46 NT2RP1001681 10.11 10.11 15.1 20.39 21.03 23.99 ** + NT2RP1001694 3.58 3.58 3.82 2.45 2.38 1.97 ** - NT2RP2000001 5.23 5.23 5.53 4.17 4.54 3.74 ** - NT2RP2000006 3.49 3.49 7.32 4.12 3.88 3.4 NT2RP2000007 3.18 3.18 6.56 4.68 5.66 4.92 NT2RP2000008 2.77 2.77 6.72 3.66 5.3 4.9 NT2RP2000010 2.89 2.89 5.59 2.99 5.06 2.5 NT2RP2000011 7.08 7.08 17.96 14.55 14.74 15.15 NT2RP2000027 2.28 2.28 7.42 4.52 4.89 3.61 NT2RP2000028 22.93 22.93 62.54 46.48 51.47 53.47 NT2RP2000032 2.5 2.5 5.85 3.11 3.71 6.42 NT2RP2000040 11.57 11.57 23.92 14.38 14.5 23.1 NT2RP2000042 5.28 5.28 10.32 6.89 7.21 12.64 NT2RP2000045 5.7 5.7 9.42 5.27 6.45 6.3 NT2RP2000051 3.16 3.16 6.29 9.23 9.96 9.53 ** + NT2RP2000054 2.55 2.55 6.42 3.81 5.42 2.53 NT2RP2000056 3.68 3.68 6.23 5.67 6.89 5.8 NT2RP2000057 60.79 60.79 174.83 212.63 239.81 221.98 * + NT2RP2000067 3.1 3.1 3.86 2.98 4.36 5.72 NT2RP2000070 2.91 2.91 6.27 5.7 5.95 8.21 NT2RP2000076 1.66 1.66 4.45 2.98 3.58 3.23 NT2RP2000077 1.67 1.67 4.73 2.43 4.94 3.14 NT2RP2000079 3.76 3.76 9.24 5.15 4.81 5.47 NT2RP2000088 2.9 2.9 5.22 2.18 3.07 2.21 NT2RP2000091 5.84 5.84 6.54 6.62 8.28 6.72 NT2RP2000092 4.37 4.37 6.7 6.06 7.67 5.65 NT2RP2000097 2.74 2.74 3.39 3.4 4.13 4.13 * + NT2RP2000098 3.44 3.44 6.83 6.69 9.01 6.27 NT2RP2000108 1.93 1.93 7.24 4.8 6.31 6.68 NT2RP2000114 1.95 1.95 3.65 2.58 4.41 2.9 NT2RP2000116 3.17 3.17 7.36 5.35 3.85 9.42 NT2RP2000119 3.14 3.14 7.16 4.58 7.96 5.6 NT2RP2000120 3.91 3.91 7.62 5.57 8.5 5.8 NT2RP2000126 2.86 2.86 4.86 3.88 5.1 3.44 NT2RP2000133 1.83 1.83 3.66 3.13 4.05 2.01 NT2RP2000147 6.28 6.28 12.88 11.64 6.51 8.58 NT2RP2000153 4.61 4.61 9.55 10.57 6.49 12.05 NT2RP2000156 3.27 3.27 8.24 5.59 6.55 4.07 NT2RP2000157 3.7 3.7 6.33 6.57 5.02 4.15 NT2RP2000161 4.45 4.45 8.82 7.52 7.5 6.02 NT2RP2000168 4.22 4.22 12.63 3.94 6.03 3.88 NT2RP2000173 12.56 12.56 81.37 72.12 92.12 78.68 NT2RP2000175 1.9 1.9 3.78 2.03 3.33 4.43 NT2RP2000178 2.06 2.06 6.06 3.23 3.01 3.81 NT2RP2000183 1.64 1.64 7.82 5.82 6.21 6.03 NT2RP2000195 3.1 3.1 6.65 6 6.71 3.22 NT2RP2000204 73.6 73.6 93.43 102.95 40.16 62.34 NT2RP2000205 4 4 6.56 3.91 5.74 4.5 NT2RP2000208 3.06 3.06 9.42 4.23 6.77 3.36 NT2RP2000224 13.3 13.3 31.75 18.34 21.15 20.93 NT2RP2000230 9.96 9.96 18.99 12.16 16.4 11.95 NT2RP2000231 4.3 4.3 7.41 4.24 3.43 4.54 NT2RP2000232 1.08 1.08 2.75 1.53 2.45 0.74 NT2RP2000233 8.04 8.04 60.44 47.2 64.72 52.31 NT2RP2000239 3 3 4.7 8.93 8.93 7.01 ** + NT2RP2000240 2.01 2.01 5.25 2.49 3.41 1.45 NT2RP2000248 4.29 4.29 6.09 2.82 2.39 0.96 * - NT2RP2000256 5.7 5.7 8.25 5.62 6.22 5.44 NT2RP2000257 3.47 3.47 6.92 4.86 6.52 4.34 NT2RP2000258 1.53 1.53 3.83 3.88 2.93 3.02 NT2RP2000261 2.95 2.95 3.94 4.47 3.59 2.91 NT2RP2000270 3.12 3.12 6.26 6.66 4.06 4.3 NT2RP2000274 1.78 1.78 3.87 3.48 5.16 2.56 NT2RP2000277 2.18 2.18 6.13 3.19 4.02 2.98 NT2RP2000279 2.26 2.26 4.92 2.43 2.52 2.17 NT2RP2000283 5.75 5.75 27.65 21.53 27.32 24.78 NT2RP2000288 6.29 6.29 7.46 8.9 10.89 8.64 * + NT2RP2000289 1.12 1.12 2.79 3.09 2.77 1.93 NT2RP2000297 2.57 2.57 5.7 4.8 4.53 6.09 NT2RP2000298 3.61 3.61 9.64 8.51 7.66 8.24 NT2RP2000310 1.43 1.43 2.3 2.46 3.41 1.7 NT2RP2000327 2.12 2.12 3.96 3.13 3.49 1.57 NT2RP2000328 6.95 6.95 11.56 13.43 16.7 14.68 * + NT2RP2000329 10.73 10.73 10.17 17.55 23.92 18.52 ** + NT2RP2000333 6.35 6.35 6.4 6.83 7.17 4.64 NT2RP2000337 2.05 2.05 5.16 4.43 5.32 5.31 NT2RP2000346 2.55 2.55 5.18 7.2 5.63 4.95 NT2RP2000357 1.57 1.57 6.87 5.48 5.14 5.35 NT2RP2000358 2.09 2.09 4.52 5.03 4.9 4.01 NT2RP2000366 3.23 3.23 4.08 4.16 4.25 2.32 NT2RP2000369 7.22 7.22 9.94 44.13 45.2 44.34 ** + NT2RP2000376 26.92 26.92 108.62 84.48 134.63 85.95 NT2RP2000394 6.49 6.49 5.92 5.08 8.52 4.21 NT2RP2000396 2.71 2.71 6.55 7.52 6.8 5.02 NT2RP2000412 4.48 4.48 23.45 21.42 24.93 20.49 NT2RP2000414 8.03 8.03 18.69 23.83 18.98 23.37 NT2RP2000420 1.12 1.12 4.11 3.54 3.25 1.97 NT2RP2000422 6.41 6.41 13.18 17.56 17.88 18.67 * + NT2RP2000426 21.59 21.59 80.94 87.94 110.97 74.98 NT2RP2000428 24.92 24.92 43.91 34.21 35.59 30.95 NT2RP2000438 5.06 5.06 5.17 5.62 6.94 5.11 NT2RP2000447 4.14 4.14 9.68 7.3 7.08 7.16 NT2RP2000448 3.03 3.03 4.63 4.57 3.57 3.17 NT2RP2000459 2.47 2.47 4.93 2.82 3.15 2.09 NT2RP2000479 3.3 3.3 7.51 5.33 5.71 5.06 NT2RP2000498 3.07 3.07 6.25 4.48 5.09 3.9 NT2RP2000503 2.47 2.47 4.46 2.54 2.82 1.52 NT2RP2000510 4.01 4.01 6.19 5.08 6.45 3.7 NT2RP2000514 2.65 2.65 2.51 1.94 2.25 1.63 * - NT2RP2000516 4.72 4.72 9.77 4.92 5.29 5.18 NT2RP2000523 2.21 2.21 3.17 1.92 2.44 2.63 NT2RP2000533 17.82 17.82 29.05 22.57 27.56 30.78 NT2RP2000540 1.98 1.98 4.66 3.01 5.41 5.18 NT2RP2000547 3.1 3.1 5.26 4.38 5.27 3.71 NT2RP2000557 4.26 4.26 6.96 4.34 6.5 3.32 NT2RP2000558 3.43 3.43 7.17 6.43 7.11 8.26 NT2RP2000564 3.04 3.04 7.2 3.49 8.03 4.77 NT2RP2000565 4.54 4.54 11.07 7.64 9.24 9.98 NT2RP2000583 14.8 14.8 44.9 49.6 34.93 49.08 NT2RP2000591 0.81 0.81 3.81 1.53 2.61 1.21 NT2RP2000599 1.85 1.85 4.1 1.97 3.43 2.36 NT2RP2000601 1.78 1.78 4.67 1.28 2.48 1.3 NT2RP2000603 2.58 2.58 4.44 2.54 2.84 2.98 NT2RP2000610 3.77 3.77 7.23 6.32 7.62 5.53 NT2RP2000614 75.85 75.85 129.42 130.63 184.38 188.58 * + NT2RP2000616 1.81 1.81 4.89 3.9 5.1 3.83 NT2RP2000617 2.17 2.17 6.73 5.78 6.82 6.26 NT2RP2000623 3.1 3.1 5.36 3.46 5.1 3.49 NT2RP2000634 1.56 1.56 3.92 2.29 3.34 2.02 NT2RP2000636 3.78 3.78 8.64 6.27 7.6 6.62 NT2RP2000638 4.37 4.37 8.91 4.57 7.41 5.69 NT2RP2000644 2.22 2.22 5.47 3.41 4.16 3.45 NT2RP2000649 8.96 8.96 15.76 13.65 17.22 13.07 NT2RP2000652 3.35 3.35 4.58 3.57 4.36 2.72 NT2RP2000656 3.73 3.73 6.93 4.83 3.91 4.08 NT2RP2000658 1.08 1.08 2.64 1.51 3.18 1.43 NT2RP2000663 4.23 4.23 6.9 5.98 7.21 5.9 NT2RP2000664 4.24 4.24 10.24 12.72 12.54 16.44 * + NT2RP2000668 7.49 7.49 26.84 16.92 20.41 17.17 NT2RP2000678 1.77 1.77 3.19 1.77 2.09 1.13 NT2RP2000694 4.89 4.89 8.39 11.06 13 13.36 ** + NT2RP2000704 1.8 1.8 5.63 2.99 3.13 3.67 NT2RP2000710 4.51 4.51 9.96 6.72 8.08 7.23 NT2RP2000712 1.43 1.43 5.35 3.39 3.57 2.95 NT2RP2000715 3.42 3.42 7.43 6.04 7.56 4.49 NT2RP2000720 4.92 4.92 11.76 7.24 8 7.11 NT2RP2000731 3.92 3.92 9.15 3.7 4.5 2.61 NT2RP2000739 3.23 3.23 5.67 2.62 3.32 5.65 NT2RP2000748 1.59 1.59 4.2 1.42 1.81 1.62 NT2RP2000749 11.84 11.84 21.88 14.4 8.47 13.91 NT2RP2000758 1.6 1.6 3.17 2.65 6 1.17 NT2RP2000764 1.51 1.51 5.74 2.95 5.22 1.95 NT2RP2000766 9.08 9.08 52.24 46.37 59.37 52.89 NT2RP2000777 12.28 12.28 18.43 26.91 28.56 24.47 ** + NT2RP2000786 21.32 21.32 73.91 55.85 67.59 58.16 NT2RP2000793 5.32 5.32 6.9 4.32 3.57 4.38 * - NT2RP2000796 5.32 5.32 7.41 7.38 9.17 6.66 NT2RP2000809 3.25 3.25 8.3 6.46 4.69 5.45 NT2RP2000812 6.65 6.65 17.51 16.43 14.35 16.89 NT2RP2000814 4.16 4.16 4.97 3.75 4.6 3.29 NT2RP2000816 1.84 1.84 5.64 4.64 5.19 3.58 NT2RP2000818 3.28 3.28 5.19 3.18 3.66 1.95 NT2RP2000819 2.76 2.76 5.79 3.03 3.05 1.94 NT2RP2000841 4.35 4.35 4.51 2.17 2.48 1.65 ** - NT2RP2000842 7.8 7.8 9.57 13.62 14.25 12.66 ** + NT2RP2000845 2.52 2.52 8.31 7.51 6.76 6.93 NT2RP2000863 2.45 2.45 3.48 3.82 3.37 2.47 NT2RP2000880 5.96 5.96 11.61 9.5 11.13 10.25 NT2RP2000892 4.3 4.3 6.43 6.54 6.97 5.01 NT2RP2000894 5.59 5.59 11.88 5.41 5.59 2.16 NT2RP2000903 5.71 5.71 9.12 10.73 11.92 7.44 NT2RP2000906 4.56 4.56 5.39 2.63 3.78 2.19 * - NT2RP2000910 4.34 4.34 4.26 2.9 2.7 1.68 ** - NT2RP2000931 10.97 10.97 18.36 20.51 19.28 24.6 NT2RP2000932 2.86 2.86 5.43 4.8 4.72 4.21 NT2RP2000938 18.41 18.41 42.99 35.71 30.01 43.52 NT2RP2000943 7.02 7.02 14.98 18.7 14.88 14.48 NT2RP2000957 3.19 3.19 4.11 4.26 3.66 2.71 NT2RP2000958 7 7 6.84 10.43 12.36 7.8 NT2RP2000959 9.88 9.88 14.99 13.92 17.38 10.69 NT2RP2000965 5.05 5.05 7.82 15.73 18.97 16.02 ** + NT2RP2000970 2.31 2.31 6.72 5.14 5 4.62 NT2RP2000973 0.9 0.9 1.47 2.56 2.64 1.57 * + NT2RP2000985 2.69 2.69 6 9.28 6.29 13.98 NT2RP2000987 1.89 1.89 3.31 4.54 3.17 1.66 NT2RP2000997 13.83 13.83 23.99 38.12 29.73 40.96 * + NT2RP2001024 2.86 2.86 5.34 3.61 3.12 2.36 NT2RP2001028 4.66 4.66 4.2 2.65 4.09 0.99 NT2RP2001036 5.14 5.14 8.86 6.16 6.44 4.91 NT2RP2001039 1.08 1.08 3.18 3.47 1.14 2.24 NT2RP2001044 1.13 1.13 2.5 2.53 1.89 2.8 NT2RP2001056 4.97 4.97 28.32 20.16 26.9 18.16 NT2RP2001065 2.38 2.38 6.24 7.45 7.4 5.69 NT2RP2001067 2.98 2.98 5.38 4.12 5.29 2.41 NT2RP2001070 3.3 3.3 7.63 4.72 6.17 3.58 NT2RP2001081 2.91 2.91 8.19 4.8 6.68 3.9 NT2RP2001087 3.93 3.93 2.36 2.06 2.92 1.61 NT2RP2001094 0.69 0.69 1.37 1.25 1.15 1.04 NT2RP2001119 2.02 2.02 6.11 5.86 4.44 4.35 NT2RP2001127 1.53 1.53 4.04 2.69 1.85 2.1 NT2RP2001133 2.45 2.45 4.73 4.06 3.61 3.6 NT2RP2001137 2.68 2.68 4.07 2.3 2.82 2.9 NT2RP2001142 3.88 3.88 7.47 3.37 2.83 2.42 NT2RP2001149 2.7 2.7 2.98 2.11 3.39 1.32 NT2RP2001168 6 6 7.81 6.8 7.01 5.75 NT2RP2001173 4.15 4.15 7.88 3.98 3.09 5.44 NT2RP2001174 9.23 9.23 14.98 14.12 15.45 18.01 NT2RP2001184 2.78 2.78 5.46 4.21 7.18 4.64 NT2RP2001196 1.62 1.62 5.93 3.14 3.28 2.94 NT2RP2001200 3.85 3.85 9.36 5.02 4.25 7.88 NT2RP2001218 2.29 2.29 5.69 2.55 3.89 3.6 NT2RP2001223 2.65 2.65 5.03 1.95 3.69 3.31 NT2RP2001226 4.34 4.34 10.19 6.95 5.72 7.35 NT2RP2001227 4.45 4.45 6.12 3.2 3.62 6.01 NT2RP2001232 6.44 6.44 13.95 7.13 9.79 13.66 NT2RP2001233 4.02 4.02 10.57 7.04 7.77 8.01 NT2RP2001245 4.21 4.21 8.03 9.47 11.82 11.16 * + NT2RP2001246 6.3 6.3 9.84 9 11.28 11.57 NT2RP2001268 6.19 6.19 18.1 17.61 16.26 18.55 NT2RP2001270 4.78 4.78 9.11 5.68 8.7 10.04 NT2RP2001276 4.92 4.92 13.29 12.73 10.92 12.73 NT2RP2001277 3.11 3.11 7.02 4.91 6.22 10.82 NT2RP2001290 2.71 2.71 6.46 4.42 5.61 6.01 NT2RP2001295 5.46 5.46 9.44 5.13 5.98 7.92 NT2RP2001297 118.17 118.17 120.73 139.11 97.16 145.76 NT2RP2001301 9.12 9.12 18.56 15.89 19.62 14.24 NT2RP2001312 2.7 2.7 5.68 5.6 4.59 6.04 NT2RP2001327 4.73 4.73 5.69 6.39 8.53 11.86 NT2RP2001328 8.44 8.44 20.87 16.32 23.25 23.16 NT2RP2001341 4.59 4.59 9.22 3.06 7.65 7.21 NT2RP2001347 3.09 3.09 8.54 5.54 9.55 6.9 NT2RP2001366 10.33 10.33 48.06 54.83 51.5 52.33 NT2RP2001378 2.33 2.33 3.77 3.74 4.64 5.02 NT2RP2001381 2.82 2.82 6.86 5.79 6.62 8.37 NT2RP2001388 3.25 3.25 6.71 4.54 5.11 5.2 NT2RP2001391 443.52 443.52 734.13 742.83 990.71 747.95 NT2RP2001392 2.98 2.98 6.43 4.58 3.16 4.18 NT2RP2001394 3.3 3.3 8.55 8.35 6.09 10.15 NT2RP2001397 5.04 5.04 6.79 7.33 5.68 12.2 NT2RP2001400 3.1 3.1 6.4 3.43 6.25 2.92 NT2RP2001408 3.31 3.31 6.13 4.02 5.97 5.62 NT2RP2001420 5.63 5.63 12.09 8.09 9.97 9.17 NT2RP2001423 4.71 4.71 9.71 6.21 8.29 7.19 NT2RP2001427 2.68 2.68 5.32 3.69 4.61 5.49 NT2RP2001428 2.71 2.71 7.13 5.49 3.78 3.03 NT2RP2001436 4.27 4.27 8.85 5.84 2.85 4.84 NT2RP2001440 2.89 2.89 7.34 10.24 10.15 11.98 * + NT2RP2001445 2.43 2.43 6.75 5.86 5.55 5.89 NT2RP2001449 4.37 4.37 6.41 5 4.74 5.02 NT2RP2001450 3.19 3.19 6.75 2.26 5.4 8.59 NT2RP2001467 4.53 4.53 10.28 5.32 4.72 6.5 NT2RP2001469 4.74 4.74 6.79 8.22 11.04 7.18 NT2RP2001480 6.54 6.54 26.68 14.98 12.63 15.42 NT2RP2001495 5.86 5.86 11.96 8.16 9.04 10.39 NT2RP2001499 8.25 8.25 16.78 10.05 14.46 9.66 NT2RP2001506 2.79 2.79 7.24 5.32 8.19 5.33 NT2RP2001508 10.59 10.59 13.66 18.74 20.49 21.92 ** + NT2RP2001511 6.41 6.41 9.74 6.08 8.63 6.53 NT2RP2001514 7.04 7.04 7.02 7.24 6.44 6.38 NT2RP2001520 2.93 2.93 4.84 2.6 3.19 2.87 NT2RP2001526 3.88 3.88 8.49 7.01 5.27 3.83 NT2RP2001529 9.87 9.87 53.78 44.74 55.72 60.88 NT2RP2001536 1.63 1.63 4.17 3.81 4.52 4.71 NT2RP2001538 83.44 83.44 178.68 132.75 146.73 155.87 NT2RP2001547 4.96 4.96 14.87 16.77 19.21 17.77 * + NT2RP2001560 6.28 6.28 21.64 25.41 28.19 27.75 * + NT2RP2001562 5.56 5.56 5.57 5.94 6.75 4.64 NT2RP2001566 7.96 7.96 9.24 8.22 7.91 8.56 NT2RP2001569 4.26 4.26 8.71 6.09 5.65 8.28 NT2RP2001576 3.95 3.95 11.58 13.42 9 12.82 NT2RP2001581 47.15 47.15 130.15 121.19 112.28 129.54 NT2RP2001597 3.73 3.73 7.88 8.57 8.3 13.3 NT2RP2001601 2.37 2.37 4.81 3.67 4.81 3.34 NT2RP2001613 2.74 2.74 4.87 2.83 2.72 4.15 NT2RP2001628 3.42 3.42 3.97 3.14 3.04 7.84 NT2RP2001634 8.64 8.64 13.94 16.57 23.67 17.67 * + NT2RP2001635 2.51 2.51 5.92 5.63 5.53 4.72 NT2RP2001660 4.27 4.27 16.91 5.9 5.54 10.06 NT2RP2001662 1.49 1.49 4.07 4.5 4.44 3.47 NT2RP2001663 2.82 2.82 5.09 10.37 8.21 9.74 ** + NT2RP2001672 3.28 3.28 3.82 3.88 4.09 4 * + NT2RP2001675 4.1 4.1 5.01 5.23 4.73 5.06 NT2RP2001677 9.58 9.58 18.2 20.9 26.67 19.74 * + NT2RP2001678 4.84 4.84 6.73 4.6 4.83 4.5 NT2RP2001683 1.89 1.89 3.12 4.6 4.72 2.78 NT2RP2001699 3.15 3.15 6.16 6.5 5.84 4.88 NT2RP2001707 1.24 1.24 3.19 3.42 4.13 4.8 * + NT2RP2001720 1.47 1.47 3.6 3.91 3 2.72 NT2RP2001721 2.26 2.26 4.57 5.53 3.96 3.66 NT2RP2001740 12 12 60.21 52.38 79.71 54.73 NT2RP2001748 6.43 6.43 10.8 8.75 10.25 8.55 NT2RP2001755 5.51 5.51 4.96 3.71 4.62 2.69 * - NT2RP2001762 1.25 1.25 2.01 3.87 2.56 3.52 * + NT2RP2001768 1.91 1.91 4.7 6.7 5.55 4.55 NT2RP2001769 3.06 3.06 5.86 10.42 5.06 11.86 NT2RP2001784 3.62 3.62 6.23 7.06 6.02 6.91 NT2RP2001805 2.33 2.33 5.61 6.02 4.93 6.6 NT2RP2001813 2.75 2.75 3.73 1.84 1.98 1.94 * - NT2RP2001817 3.16 3.16 4.49 4.03 5.32 3.45 NT2RP2001818 2.72 2.72 2.45 2.35 3.62 2.66 NT2RP2001837 5.13 5.13 13.43 10.29 10.16 12.33 NT2RP2001839 17.02 17.02 83.84 60.14 71.06 82.26 NT2RP2001861 2 2 6.37 3.16 3.52 3.87 NT2RP2001869 2.64 2.64 6.54 4.35 5.77 8.84 NT2RP2001876 12.15 12.15 27.71 24.54 24.93 23.67 NT2RP2001878 2.32 2.32 3.96 2.95 3.32 4.95 NT2RP2001881 3.72 3.72 5.4 9.67 12.64 12.16 ** + NT2RP2001883 2.63 2.63 6.8 4.33 5.42 6.35 NT2RP2001884 13.59 13.59 23.56 15.33 10.54 23.6 NT2RP2001885 3.27 3.27 5.49 2.88 4.39 4.82 NT2RP2001898 10.76 10.76 80.37 69.48 88.43 73.46 NT2RP2001900 3.38 3.38 4.03 2.61 4.93 10.26 NT2RP2001903 3.73 3.73 7.71 5.57 5.7 8.2 NT2RP2001907 3.1 3.1 8.56 5.05 7.56 6.72 NT2RP2001915 2.89 2.89 5.06 4.06 3.08 7.19 NT2RP2001921 4.04 4.04 10.3 13.02 12.45 19.33 * + NT2RP2001926 2.75 2.75 8.25 3.55 5.3 5.64 NT2RP2001933 5.65 5.65 52.55 43.62 43.55 48.58 NT2RP2001936 1.54 1.54 5.03 2.8 2.96 3.8 NT2RP2001943 25.33 25.33 49.4 47.71 40.48 51.65 NT2RP2001946 3.05 3.05 4.3 3.41 4.51 6.1 NT2RP2001947 3.18 3.18 3.44 3.93 3.21 6.88 NT2RP2001948 3.59 3.59 10.79 5.71 7.29 19.72 NT2RP2001956 5.24 5.24 12.73 11.54 9.42 9.89 NT2RP2001969 4.05 4.05 7.82 3.24 5.7 6 NT2RP2001976 2.9 2.9 6.39 5.68 6.95 6.41 NT2RP2001978 3.26 3.26 6.08 4.18 4.83 6.03 NT2RP2001985 2.14 2.14 3.8 2.56 4.63 2.51 NT2RP2001991 3.34 3.34 5.7 1.53 4.62 5.19 NT2RP2001997 3.16 3.16 8.43 5.31 7.47 6.98 NT2RP2002015 136.21 136.21 265.98 266.8 340.89 272.43 NT2RP2002017 3.24 3.24 6.06 2.06 3.3 2.57 NT2RP2002025 6.08 6.08 51.73 31.83 26.94 37.84 NT2RP2002030 6.06 6.06 11.95 9.77 8.07 8.76 NT2RP2002032 2.31 2.31 4.95 2.39 3.81 2.55 NT2RP2002033 3 3 6.71 3.53 7.57 8.05 NT2RP2002041 3.5 3.5 6.37 2.76 3.15 9 NT2RP2002046 3 3 6.88 2.99 7.4 6.01 NT2RP2002047 2.71 2.71 3.86 2.06 3.87 3.83 NT2RP2002050 7.67 7.67 11.66 9.78 6.47 7.77 NT2RP2002052 3.77 3.77 8.39 6.6 3.99 6.28 NT2RP2002058 2.07 2.07 4.11 3.1 4.82 3.39 NT2RP2002060 1.48 1.48 3.44 2.1 5.9 3.18 NT2RP2002063 3.61 3.61 5.83 3.3 5.2 6.65 NT2RP2002066 10.11 10.11 13.47 5.47 9.88 9.73 NT2RP2002070 3.74 3.74 6.3 2.15 3.1 3.83 NT2RP2002076 3.72 3.72 5.1 3.35 5.58 3.63 NT2RP2002078 13.09 13.09 105.74 73.87 88.51 76.08 NT2RP2002079 5.76 5.76 36.34 31.87 32.66 36.54 NT2RP2002099 4.19 4.19 5.82 4.7 6.75 6.03 NT2RP2002105 2.66 2.66 12.25 11.41 14.04 11.23 NT2RP2002115 1.63 1.63 5.21 1.98 3.42 1.52 NT2RP2002124 3.66 3.66 6 4.56 5.38 3.88 NT2RP2002137 3.99 3.99 4.83 2.21 2.1 1.76 ** - NT2RP2002139 24.08 24.08 45.74 51.88 77.99 62.3 * + NT2RP2002154 1.37 1.37 4.13 3.56 2.36 3.2 NT2RP2002155 351.63 351.63 869.83 623.53 501.61 620.68 NT2RP2002172 1.5 1.5 3.33 2.78 3.53 5.13 NT2RP2002185 3.29 3.29 7.65 7.3 8.56 8.12 NT2RP2002188 1.74 1.74 5.95 4.15 4.31 4.95 NT2RP2002192 2.9 2.9 7.6 6.65 6.42 5.83 NT2RP2002193 5.21 5.21 5.22 4.76 4.95 5.75 NT2RP2002208 5.96 5.96 7.31 4.7 5.67 5.14 NT2RP2002219 2.2 2.2 1.8 2.22 3.2 2.26 NT2RP2002231 1.72 1.72 3.1 4.11 2.76 5.76 NT2RP2002232 2.59 2.59 5.17 3.93 4.7 6.08 NT2RP2002235 5.62 5.62 15.07 16.26 16.18 15.18 NT2RP2002239 37.02 37.02 67.99 72.09 67.21 63.77 NT2RP2002252 2.64 2.64 3.66 2.63 2.76 2.94 NT2RP2002256 4.62 4.62 15.3 11.37 16.99 12.91 NT2RP2002257 7.01 7.01 22.77 18.65 25.09 20.6 NT2RP2002259 1.58 1.58 13.91 9.9 12.15 10.49 NT2RP2002264 0.6 0.6 3.14 3.2 3.12 3.92 NT2RP2002267 3.66 3.66 8.75 8.95 8.3 11.16 NT2RP2002270 4.26 4.26 8.23 16.09 10.47 14.71 * + NT2RP2002281 2.85 2.85 5.66 8.18 6.48 6.54 * + NT2RP2002288 4.32 4.32 6.6 5.33 5.56 4.23 NT2RP2002292 5.42 5.42 8.4 6.64 8.08 6.95 NT2RP2002299 9.6 9.6 9.22 11.75 19.42 15.97 * + NT2RP2002304 1.37 1.37 4.78 6.99 5.08 5.52 NT2RP2002312 1.21 1.21 2.33 3.78 5.3 3.28 * + NT2RP2002316 3.28 3.28 5.43 7.57 7.21 8.2 ** + NT2RP2002325 1.95 1.95 3.46 2.79 2.22 4.95 NT2RP2002333 2.13 2.13 3.03 3.53 4.86 5.69 * + NT2RP2002371 5.43 5.43 9.14 9.72 12.07 11.65 * + NT2RP2002373 10.65 10.65 40.1 36.72 58.84 33.58 NT2RP2002381 4.68 4.68 2.35 2.66 3.19 3.71 NT2RP2002385 5.71 5.71 11.84 9.95 11.34 9.47 NT2RP2002394 0.94 0.94 1.52 1.24 0.96 1.26 NT2RP2002408 2.7 2.7 5.08 3.89 3.12 4.29 NT2RP2002409 3.73 3.73 10.81 10.78 7.95 8.35 NT2RP2002424 2.98 2.98 4.22 5.84 6.22 7.85 * + NT2RP2002426 6.44 6.44 11.38 7.59 8.46 8.93 NT2RP2002429 17.2 17.2 24.73 27.87 33.96 20.83 NT2RP2002437 4.61 4.61 5.98 4.83 6.47 4.79 NT2RP2002439 3.83 3.83 6.69 2.68 3.22 4 NT2RP2002442 13.63 13.63 71.65 57.78 63.05 78.84 NT2RP2002457 3.27 3.27 5.31 4.35 4.87 5.82 NT2RP2002464 2.17 2.17 5.34 3.29 4.59 4.24 NT2RP2002475 3.11 3.11 7.88 5.3 2.83 5.43 NT2RP2002479 3.09 3.09 4.25 1.95 2.99 1.93 NT2RP2002487 1.73 1.73 5.15 1.98 2.1 3.04 NT2RP2002498 1.52 1.52 2.2 2.62 2.82 4.47 NT2RP2002503 7.63 7.63 31.85 29.32 32.02 31.84 NT2RP2002504 3.81 3.81 5.73 6 7.23 11.28 NT2RP2002510 2.65 2.65 8.92 4.68 6.59 6.85 NT2RP2002520 3.57 3.57 7.17 6.26 8.86 6.61 NT2RP2002527 5.18 5.18 6.02 9 12.37 11.22 ** + NT2RP2002533 3.34 3.34 6.27 4.83 6.94 5.88 NT2RP2002537 3.22 3.22 4.02 4.09 5.91 10.08 NT2RP2002542 4.81 4.81 4.64 5.99 5.93 9.73 NT2RP2002546 4.31 4.31 5.85 6.5 4.91 5.24 NT2RP2002549 4.06 4.06 9.33 7.68 10.49 11.65 NT2RP2002564 4.11 4.11 11.18 10.67 9.21 9.29 NT2RP2002591 2.45 2.45 7.03 3.31 4.79 5.79 NT2RP2002595 9.67 9.67 12.41 12.06 13.39 14.79 NT2RP2002602 4.19 4.19 7.53 5.68 8.96 10.42 NT2RP2002606 1.27 1.27 2.93 2.26 2.97 3.95 NT2RP2002609 6.12 6.12 9.95 4.79 5.48 7.74 NT2RP2002618 2.74 2.74 6.83 4.2 6.34 5.44 NT2RP2002621 4.24 4.24 10.22 6.58 7.52 9.79 NT2RP2002643 1.79 1.79 4.84 3.11 5.98 3.94 NT2RP2002672 4.48 4.48 9.23 8.03 9.37 9.87 NT2RP2002673 4.13 4.13 5.01 8 12.88 17.73 * + NT2RP2002674 2.4 2.4 4.06 2.78 2.37 1.84 NT2RP2002686 2.73 2.73 4.61 3.17 5.19 6.49 NT2RP2002688 10.73 10.73 28.07 22.34 33.34 28.71 NT2RP2002695 2.62 2.62 7.03 5.26 4.34 5.52 NT2RP2002701 7.29 7.29 13.37 11.85 5.18 10.04 NT2RP2002706 3.02 3.02 5.58 6.47 8.14 6.19 * + NT2RP2002710 11.2 11.2 36.97 39.43 33.9 42.75 NT2RP2002721 5.53 5.53 9.42 7.33 7.34 8.45 NT2RP2002727 3.56 3.56 6.87 2.17 3.96 3.52 NT2RP2002734 3.59 3.59 6.65 5.71 7.65 7.54 NT2RP2002736 5.25 5.25 13.13 13.17 13.59 17.58 NT2RP2002740 2 2 5.11 3.18 2.81 3.13 NT2RP2002741 2.12 2.12 4.8 4.68 5.39 5.78 NT2RP2002750 2.5 2.5 9.22 7.73 9.57 8.18 NT2RP2002752 4.59 4.59 10.39 7.93 7.66 8.03 NT2RP2002753 4.49 4.49 9.91 8.66 9.04 14.67 NT2RP2002760 4.79 4.79 10.31 3.56 4.5 4.13 NT2RP2002769 4.42 4.42 6.06 3.89 5.67 6.43 NT2RP2002778 4.13 4.13 10.59 6.8 8.2 9.12 NT2RP2002791 8.89 8.89 54.27 48.75 53.08 50.19 NT2RP2002800 1.66 1.66 4.52 4 5.19 5.38 NT2RP2002805 3.38 3.38 5.46 4.75 6.44 3.81 NT2RP2002811 3.27 3.27 8.23 5.87 8.13 10.61 NT2RP2002824 18.29 18.29 25.05 29.95 34.29 25.05 NT2RP2002839 13.26 13.26 31.21 16.09 23.42 16.27 NT2RP2002845 5.87 5.87 7.93 4.61 6.12 5.5 NT2RP2002857 2.95 2.95 3.6 2.35 4.23 2.99 NT2RP2002862 4.56 4.56 12.49 12.55 9.84 11.34 NT2RP2002880 5.27 5.27 13.89 13.5 11.56 11.1 NT2RP2002885 8.6 8.6 17.12 7.56 10.07 10.02 NT2RP2002891 1.9 1.9 7.78 4.65 6.63 7.56 NT2RP2002907 2.95 2.95 6.91 5.95 5.5 4.9 NT2RP2002925 5.67 5.67 6.73 10.04 11.6 8.45 * + NT2RP2002927 10.08 10.08 10.63 19.05 21.85 15.48 ** + NT2RP2002928 4.32 4.32 4.56 2.65 2.34 2.51 ** - NT2RP2002929 3.96 3.96 9.74 8.09 7.86 9.87 NT2RP2002934 1.5 1.5 1.4 2.81 3.01 2.49 ** + NT2RP2002939 2.96 2.96 5.09 5.15 6.71 4.91 NT2RP2002942 2.4 2.4 5.06 4.35 5.07 10.81 NT2RP2002954 5.41 5.41 11.46 7.21 9.1 8.65 NT2RP2002959 8.15 8.15 12.55 13.81 16.28 16.69 * + NT2RP2002974 5.03 5.03 6.53 4.7 3.45 4.54 NT2RP2002976 6.92 6.92 17.08 11.84 14.66 12.42 NT2RP2002979 4.41 4.41 8.12 7.03 8.66 7.6 NT2RP2002980 6.44 6.44 15.09 15.56 11 17.45 NT2RP2002986 3.87 3.87 7.6 6.68 7.4 7.39 NT2RP2002987 3.52 3.52 8.23 11.1 9.18 9.4 * + NT2RP2002988 14.96 14.96 22.92 30.07 31.87 31.36 ** + NT2RP2002993 2.97 2.97 4.18 3.8 3.84 2.84 NT2RP2003000 4.88 4.88 8.34 6.97 9.62 9.97 NT2RP2003008 4.85 4.85 5.06 3.34 4.76 4.78 NT2RP2003020 4.45 4.45 44.26 28.35 46.52 34.33 NT2RP2003032 1.91 1.91 4.02 5.82 6.48 6.59 ** + NT2RP2003034 4.21 4.21 13.47 13.16 11.15 16.31 NT2RP2003042 2.15 2.15 3.81 4.57 3.65 4.92 NT2RP2003050 2.32 2.32 3.56 2.55 2.17 1.83 NT2RP2003060 7.27 7.27 15.51 21.53 18.91 17.46 * + NT2RP2003073 5.61 5.61 8.73 7.06 10.51 8.17 NT2RP2003099 5.05 5.05 3.67 3.21 3.73 2.84 NT2RP2003108 3.6 3.6 4.23 5.29 3.91 6.62 NT2RP2003115 1.68 1.68 5 7.75 4.69 4.84 NT2RP2003117 2.71 2.71 5.69 3.6 4.66 4.13 NT2RP2003121 1.83 1.83 3.47 4.03 2.69 3.33 NT2RP2003125 4.13 4.13 11.44 15.42 12.55 13.66 * + NT2RP2003127 2.36 2.36 3.94 1.53 1.66 1.75 NT2RP2003129 3.43 3.43 7.09 6.08 6.05 5.42 NT2RP2003137 4.49 4.49 6.14 7.58 8.4 6.46 * + NT2RP2003138 4.66 4.66 20.24 16.55 17.45 16.92 NT2RP2003146 6.2 6.2 24.78 18.5 23.25 25.96 NT2RP2003148 3.09 3.09 6.73 3.06 4.6 4.04 NT2RP2003150 1.45 1.45 5.71 3.98 5.2 4.3 NT2RP2003157 6.93 6.93 34.27 34.29 31.85 32.84 NT2RP2003158 6.3 6.3 25.32 26.87 28.69 59.31 NT2RP2003161 2.73 2.73 3.36 2.51 2.82 6.12 NT2RP2003164 1.96 1.96 2.1 1.28 1.87 2.46 NT2RP2003165 2.18 2.18 5.94 3.1 3.69 4.84 NT2RP2003177 1.63 1.63 4.37 2.79 3.03 4.42 NT2RP2003179 1.23 1.23 4.98 4.08 3.63 7.96 NT2RP2003194 4.04 4.04 7.2 5.73 6.29 14.77 NT2RP2003206 1.59 1.59 4.47 1.64 3.52 1.44 NT2RP2003210 5.06 5.06 15.15 16.14 12.93 15.9 NT2RP2003227 1.62 1.62 3.97 2.04 3.66 6.28 NT2RP2003228 6.57 6.57 29.53 29.56 43.94 44.24 NT2RP2003230 3.51 3.51 7.91 4.49 8.04 8.46 NT2RP2003231 2.22 2.22 5.59 2.46 3.23 3.83 NT2RP2003237 2.52 2.52 4.59 4.59 6.4 6.46 * + NT2RP2003239 2.3 2.3 4.46 2.97 4.46 4.05 NT2RP2003243 2.16 2.16 4.13 2.38 3.28 3.98 NT2RP2003265 3.93 3.93 5.33 4.22 4.88 4.92 NT2RP2003267 2.73 2.73 3.15 3.24 4.17 7.42 NT2RP2003272 6.03 6.03 14.8 16.93 23.85 32.58 * + NT2RP2003277 3.85 3.85 11.29 5.53 8.39 6.39 NT2RP2003280 3.47 3.47 9.38 7.67 7.25 6.09 NT2RP2003286 2.18 2.18 4.23 4.13 5 9.61 NT2RP2003293 2.98 2.98 6.9 5.66 7.05 7.94 NT2RP2003295 4.67 4.67 8.45 8.73 12.39 6.35 NT2RP2003297 3.43 3.43 7.57 4.32 6.89 5.28 NT2RP2003300 20.38 20.38 32.04 45.7 53.51 48.07 ** + NT2RP2003302 2.88 2.88 4.52 3.46 3.81 7.26 NT2RP2003307 0.57 0.57 2.62 1.43 1.49 1.38 NT2RP2003308 1.44 1.44 4.5 2.77 4.44 5.44 NT2RP2003311 4.18 4.18 5.83 7.35 4.25 8.2 NT2RP2003329 2.99 2.99 4.41 2.63 3.89 4.44 NT2RP2003339 3.06 3.06 7.01 3.76 4.92 3.64 NT2RP2003345 4.15 4.15 8.38 2.77 3.97 6.33 NT2RP2003347 2.55 2.55 4.23 2.08 1.98 3.46 NT2RP2003367 2.15 2.15 4.65 2.7 1.98 1.44 NT2RP2003369 1.34 1.34 4.71 2.16 2.36 0.89 NT2RP2003383 4.05 4.05 6.75 7.66 7.17 6.99 NT2RP2003390 9.1 9.1 17.93 16.66 14.27 12.94 NT2RP2003391 9.39 9.39 12.9 11.96 9.91 12.84 NT2RP2003393 4.23 4.23 6.99 6.14 5.03 9.44 NT2RP2003394 8.67 8.67 16.21 17.56 21.75 17.23 NT2RP2003401 4.39 4.39 5.97 3.52 3.72 2.9 NT2RP2003403 3.42 3.42 7.64 6.62 8.55 7.79 NT2RP2003433 3.02 3.02 15.54 13.62 13.5 13.08 NT2RP2003445 3.2 3.2 4.74 4.08 3.5 3.93 NT2RP2003446 2.67 2.67 6.23 5.06 6.05 4.47 NT2RP2003456 2.04 2.04 6.57 4.26 5.89 3.81 NT2RP2003466 3.56 3.56 20.09 17.34 25.96 23.53 NT2RP2003469 6.2 6.2 5.65 6.19 7.53 6.33 NT2RP2003470 5.64 5.64 6.47 5.06 6.11 6.44 NT2RP2003471 2.72 2.72 3.88 3.22 2.78 3.38 NT2RP2003480 7.15 7.15 20.74 19.77 19.89 21.14 NT2RP2003495 3.99 3.99 6.03 8.07 7.24 10.72 * + NT2RP2003499 1.52 1.52 4.58 3.67 4.05 2.75 NT2RP2003505 0.98 0.98 3.21 2.62 3.88 1.4 NT2RP2003506 2.54 2.54 6.53 5.65 5.36 4.78 NT2RP2003511 3.67 3.67 5.57 4.22 3.1 2.96 NT2RP2003513 3.79 3.79 6.01 5.49 5.57 5.71 NT2RP2003517 2.9 2.9 2.52 1.32 1.11 0.85 ** - NT2RP2003522 11.08 11.08 19.77 10.55 11.42 16.52 NT2RP2003525 5.12 5.12 14.93 12.19 10.72 11.79 NT2RP2003533 3.36 3.36 10.44 12.12 10.72 12.94 NT2RP2003541 6.72 6.72 11.29 12.02 13.42 11.7 NT2RP2003543 2.48 2.48 5.96 4.17 3.55 6.54 NT2RP2003545 2.59 2.59 4.85 2.22 3.6 1.85 NT2RP2003559 4.92 4.92 4.81 3.97 3.84 3.37 ** - NT2RP2003564 4.46 4.46 3.93 2.53 1.97 2.42 ** - NT2RP2003565 4.94 4.94 50.48 41.12 48.32 37.82 NT2RP2003567 3.51 3.51 16.65 16.25 19.43 16.05 NT2RP2003575 4.44 4.44 18.78 19.56 22.63 20.7 NT2RP2003576 102.12 102.12 203.44 206.62 128.42 171.89 NT2RP2003579 11.45 11.45 26.58 38.62 39.51 39.88 * + NT2RP2003581 3.85 3.85 6.1 4.33 4.38 3.96 NT2RP2003587 8.37 8.37 11.47 13.35 14.11 12.14 * + NT2RP2003590 7.15 7.15 9.08 11.06 13.15 14.91 * + NT2RP2003593 1.58 1.58 4.57 7.84 4.43 8.59 NT2RP2003596 4.86 4.86 10.86 14.43 13.12 17.96 * + NT2RP2003599 6.49 6.49 12.46 14.29 10.17 11.98 NT2RP2003600 1.88 1.88 2.95 3.02 3.64 6.36 NT2RP2003604 7.09 7.09 8.97 16.39 13.03 16.68 ** + NT2RP2003629 3.72 3.72 5.25 3.11 4.56 2.38 NT2RP2003630 4.09 4.09 6.66 4.79 6.78 3.84 NT2RP2003643 5.49 5.49 4.88 7.15 9.8 8.51 * + NT2RP2003655 4.27 4.27 11.12 7.52 6.38 7.59 NT2RP2003664 12.29 12.29 24.31 17.9 18.07 17.11 NT2RP2003668 2.52 2.52 5.01 3.3 3.18 3.62 NT2RP2003687 1.61 1.61 2.77 1.63 2.42 1.71 NT2RP2003691 3.03 3.03 5.07 3.7 4.21 4.57 NT2RP2003702 3.99 3.99 6.14 2.89 3.02 2.89 NT2RP2003704 3.31 3.31 4.12 2.65 3.84 1.99 NT2RP2003706 2.44 2.44 1.24 1.72 1.42 1.6 NT2RP2003713 4.11 4.11 5.49 4.16 3.89 3.87 NT2RP2003714 3.39 3.39 7.8 5.19 5.31 5.32 NT2RP2003727 3.96 3.96 11.63 4.81 6.08 10.46 NT2RP2003737 2.52 2.52 8.58 4.88 6.47 4.6 NT2RP2003751 1.66 1.66 4.84 1.24 1.67 1.37 NT2RP2003760 2.52 2.52 5.47 3.87 4.19 5.45 NT2RP2003764 2.1 2.1 2.81 1.44 1.87 4.62 NT2RP2003769 5.52 5.52 11.45 7.41 8.17 10.64 NT2RP2003770 7.43 7.43 12.42 7.17 5.67 12.82 NT2RP2003777 3.44 3.44 6.78 5.01 5.6 9.57 NT2RP2003781 4.93 4.93 15.85 13.04 11.91 13.48 NT2RP2003785 9.69 9.69 13.44 11.1 10.68 8.99 NT2RP2003793 9.32 9.32 9.5 8.29 13.22 10.51 NT2RP2003806 5.6 5.6 12.03 8.54 8.75 12.97 NT2RP2003825 10.73 10.73 62.01 57.88 71.84 82.78 NT2RP2003840 3.19 3.19 6.07 3.86 4.44 4.71 NT2RP2003857 4.02 4.02 4.94 3.15 4.61 6.12 NT2RP2003859 1.82 1.82 6 3.35 4.16 4.21 NT2RP2003871 5.22 5.22 9.43 5.1 4.59 7.79 NT2RP2003876 3.82 3.82 8.8 5.92 5.87 7.92 NT2RP2003878 3.38 3.38 6.49 3.8 4.9 4.11 NT2RP2003885 2.46 2.46 3.09 1.66 3.29 2.37 NT2RP2003898 5.39 5.39 8.91 12.3 12.73 18.25 * + NT2RP2003902 5.09 5.09 10.78 8.24 8.23 10.42 NT2RP2003912 3.83 3.83 14.48 5.91 7.43 6.74 NT2RP2003931 1.81 1.81 6.03 3.95 6.86 4.42 NT2RP2003940 2.31 2.31 9.51 7.1 6.2 7.3 NT2RP2003950 2.81 2.81 5.48 3.84 5.57 2.98 NT2RP2003952 1.86 1.86 5.63 2.58 4.23 2.98 NT2RP2003968 4.82 4.82 7.38 9.86 11.76 13.51 * + NT2RP2003976 5.35 5.35 9.56 12.56 12.6 13.2 * + NT2RP2003981 3.27 3.27 7.41 4.62 2.03 4.07 NT2RP2003984 5.57 5.57 15.87 10.21 4.25 10.34 NT2RP2003986 2.79 2.79 6.22 6.29 6.32 5.17 NT2RP2003988 2.36 2.36 6.84 4.51 7.42 5 NT2RP2004013 8.46 8.46 13.75 14.68 13.19 17 NT2RP2004014 4.24 4.24 10.07 4.06 5.12 4.08 NT2RP2004036 6.88 6.88 14.85 14.08 19.02 16.03 NT2RP2004041 2.77 2.77 5.02 3.96 4.43 5.19 NT2RP2004042 1.99 1.99 4.6 4.41 2.02 4.09 NT2RP2004049 4.68 4.68 19.13 14.24 15.5 16.3 NT2RP2004060 5.7 5.7 10.41 7.09 8.67 10.84 NT2RP2004066 2.17 2.17 4.31 3.05 4.83 3.65 NT2RP2004069 3.99 3.99 7.24 3.54 6 4.26 NT2RP2004076 3.73 3.73 5.82 1.92 4.2 3.61 NT2RP2004080 4.21 4.21 9.26 4.45 6.47 6.15 NT2RP2004081 3.27 3.27 5.39 3.51 3.71 4.5 NT2RP2004098 2.32 2.32 6.48 5.4 3.1 5.75 NT2RP2004108 3.82 3.82 9.56 7.18 5.89 7.56 NT2RP2004124 3.13 3.13 5.9 3.68 5.82 3.92 NT2RP2004130 3.67 3.67 9.32 5.51 9.12 8.4 NT2RP2004133 2.05 2.05 6.41 3.69 6.54 6.25 NT2RP2004141 5.72 5.72 7.15 5.14 7.05 7.05 NT2RP2004142 5.33 5.33 8.1 4.18 5.45 3.93 NT2RP2004152 3.34 3.34 4.78 5.7 7.49 4.39 NT2RP2004165 3.71 3.71 8.3 5.87 5.92 6.54 NT2RP2004170 1.86 1.86 5.97 5.37 4.17 4.94 NT2RP2004172 2.93 2.93 5.24 4.69 5.58 4.26 NT2RP2004176 3.45 3.45 8.4 7.77 10.21 8.98 NT2RP2004179 4.01 4.01 9.17 3.94 5.07 4.15 NT2RP2004187 3.16 3.16 6.36 3.87 3.88 4.59 NT2RP2004190 5.1 5.1 5.46 5.49 7.33 9.98 NT2RP2004194 7.54 7.54 14.57 18.5 23.44 19.83 * + NT2RP2004196 4.28 4.28 13.77 10.02 7.87 14.61 NT2RP2004205 2.67 2.67 8.14 8.64 6.62 7.81 NT2RP2004207 2.57 2.57 4.38 4.15 4.97 3.59 NT2RP2004226 2.09 2.09 4.95 4.11 6.15 5.33 NT2RP2004232 2.79 2.79 6.52 6 6.59 5.33 NT2RP2004239 3.57 3.57 4.49 2.71 3.97 5.6 NT2RP2004240 7.07 7.07 12.57 13 15.8 8.95 NT2RP2004242 3.87 3.87 6.52 5.77 6.94 7.27 NT2RP2004245 1.74 1.74 3.47 2.42 3.29 3.15 NT2RP2004270 9.77 9.77 33.78 28.39 27.43 29.48 NT2RP2004300 2 2 5.22 4.34 4.52 3.26 NT2RP2004304 6.46 6.46 15.37 17.41 12.33 13.9 NT2RP2004313 3.17 3.17 3.78 5.51 4.18 4.63 * + NT2RP2004316 3.46 3.46 5.84 4.9 4.96 4.04 NT2RP2004321 4.71 4.71 6.06 6.79 7.43 6.29 * + NT2RP2004336 4.19 4.19 4.97 2.73 4.28 4.53 NT2RP2004339 5.3 5.3 20.89 17.11 18.07 15.39 NT2RP2004347 1.39 1.39 3.99 4.78 5 4.19 NT2RP2004364 2.26 2.26 6.52 5.08 6.72 4.76 NT2RP2004365 3.18 3.18 6.58 6.68 6.34 7.7 NT2RP2004366 2.49 2.49 6.06 4.49 4.71 3.08 NT2RP2004373 8.17 8.17 14.38 7.1 7.22 5.91 NT2RP2004375 9.27 9.27 13.98 20.89 26.85 20.68 ** + NT2RP2004389 5.25 5.25 5.62 5.01 6.26 5.61 NT2RP2004392 8.88 8.88 23.7 13.04 19.48 20.89 NT2RP2004396 1.98 1.98 6.27 6.65 4.98 6.17 NT2RP2004399 5.24 5.24 8.12 12.56 7.74 9.52 NT2RP2004400 2.07 2.07 3.55 2.36 3.47 2 NT2RP2004404 15.79 15.79 46 45.56 40.89 41.74 NT2RP2004410 16.64 16.64 24.04 27.99 33.46 32.69 * + NT2RP2004412 5.84 5.84 6.74 7.37 9.71 7.37 NT2RP2004414 4.27 4.27 5.09 3.81 4.89 3.8 NT2RP2004425 3.71 3.71 6.53 3.73 3.18 4.04 NT2RP2004447 1.93 1.93 5.68 2.75 5.22 3.56 NT2RP2004463 13.57 13.57 16.23 16.84 16.25 20.26 NT2RP2004476 9.11 9.11 12.69 11.89 12.66 15.87 NT2RP2004488 3.82 3.82 8.52 4.59 6.02 5.37 NT2RP2004490 2.88 2.88 3.86 2.31 2.96 4.1 NT2RP2004495 35.59 35.59 88.76 96.31 109.31 123.5 * + NT2RP2004512 4.25 4.25 7.62 5.84 6.41 7.12 NT2RP2004523 5.18 5.18 11.04 8.44 7.56 10.21 NT2RP2004524 2.19 2.19 6.33 4.97 5.32 5.56 NT2RP2004536 8.99 8.99 16.96 14.1 14.51 17.51 NT2RP2004538 8.03 8.03 24.44 20.15 25.59 22.24 NT2RP2004548 4.45 4.45 9.92 7.39 9.1 10.51 NT2RP2004551 4.95 4.95 5.62 7.17 9.98 6.21 NT2RP2004556 83.73 83.73 210.17 226.48 298.92 241.84 NT2RP2004568 5.19 5.19 11.18 6.52 9.16 9.99 NT2RP2004580 3.98 3.98 7.71 5.71 7.88 7.04 NT2RP2004585 11.28 11.28 49.82 36.69 46.91 64.56 NT2RP2004587 1.85 1.85 4.16 2.07 2.89 3 NT2RP2004594 4.56 4.56 9.24 11.47 12.21 28.18 NT2RP2004600 3.49 3.49 5.76 2.22 3.22 3.09 NT2RP2004602 4.62 4.62 6.32 6 8.49 6.26 NT2RP2004606 392.21 392.21 581.19 612.4 897.5 764.63 * + NT2RP2004614 2.92 2.92 4.73 2.69 3.63 3.81 NT2RP2004648 2.52 2.52 4.96 3.24 5.01 4.12 NT2RP2004655 5.69 5.69 10.1 8.37 6.76 9.46 NT2RP2004664 3.64 3.64 5.35 3.59 4.62 5.97 NT2RP2004670 1.98 1.98 3.81 1.98 3.71 4.27 NT2RP2004675 3.37 3.37 9.29 4.08 5.87 5.33 NT2RP2004681 3.46 3.46 7.56 5.72 8.92 7.55 NT2RP2004689 2.63 2.63 5.75 5.75 4.73 7.87 NT2RP2004709 3.93 3.93 7.79 4.46 2.89 5.25 NT2RP2004710 3.15 3.15 8.37 5.63 4.61 6.88 NT2RP2004721 1.79 1.79 5.99 3.39 4.41 2.78 NT2RP2004736 3.26 3.26 5.81 6.11 4.79 4.63 NT2RP2004743 4.94 4.94 7.96 5.94 6.67 7.36 NT2RP2004750 6.21 6.21 17.46 11.9 15.49 11.01 NT2RP2004755 11.65 11.65 19.9 14.84 22.87 19.91 NT2RP2004767 3.54 3.54 9 4.05 5.8 4.81 NT2RP2004768 3.48 3.48 29.51 18.48 18.73 19.6 NT2RP2004775 4.68 4.68 5.68 7.71 5.62 8.26 NT2RP2004791 7.23 7.23 16.58 9.33 10.24 11.68 NT2RP2004794 14.01 14.01 25.74 23.04 16.86 22.78 NT2RP2004795 5.15 5.15 7.97 6.96 5.67 11.2 NT2RP2004799 6.74 6.74 10.99 5.35 8.58 6.3 NT2RP2004802 6.35 6.35 11.79 6.1 7.62 6.24 NT2RP2004810 3.44 3.44 8.83 7.37 7.84 6.03 NT2RP2004816 5.58 5.58 12.1 11.22 8.76 11.15 NT2RP2004837 4.13 4.13 9.89 10.43 7.23 12.98 NT2RP2004841 0.91 0.91 2.86 3.69 4.03 8.87 NT2RP2004847 3.25 3.25 13.75 13.82 13.87 17.16 NT2RP2004861 2.3 2.3 5.23 2.33 4.23 2.46 NT2RP2004897 3.35 3.35 6.43 4.26 3.27 3.35 NT2RP2004932 6.64 6.64 10.16 7.96 8.53 6.91 NT2RP2004933 4.63 4.63 3.41 2.98 2.93 3.2 * - NT2RP2004936 3.69 3.69 6.41 4.56 4.42 7.53 NT2RP2004951 2.98 2.98 10.48 5.09 5.22 19.28 NT2RP2004959 3.13 3.13 6.61 6.43 6.26 6.5 NT2RP2004961 2.1 2.1 4.79 4.89 6.49 5.44 NT2RP2004962 2.27 2.27 7.28 4.5 5.57 4.47 NT2RP2004966 2.26 2.26 6.07 4.1 4.1 2.97 NT2RP2004967 3.87 3.87 6.16 4.07 4.82 3.26 NT2RP2004974 5.27 5.27 5.43 3.59 3.47 3.89 ** - NT2RP2004978 2.68 2.68 5.26 4.17 6.39 5.09 NT2RP2004982 0.57 0.57 1.82 2.2 1.94 1.72 NT2RP2004985 16.03 16.03 45.34 44.65 46.12 54.4 NT2RP2004999 2.21 2.21 5.64 4.27 8.86 10.34 NT2RP2005000 3.62 3.62 5.76 4.33 4.76 4.65 NT2RP2005001 5.41 5.41 7.91 8.26 9.15 8.32 NT2RP2005003 3.8 3.8 7.2 6.11 7.91 6.2 NT2RP2005012 6.61 6.61 20.14 18.41 20.96 17.87 NT2RP2005018 1.9 1.9 4.24 3.29 2.24 2.91 NT2RP2005020 6.12 6.12 23.58 19.97 19.94 22.96 NT2RP2005022 1.65 1.65 5.01 5.09 7.24 4.77 NT2RP2005027 5.96 5.96 38.61 42.51 40.08 33.77 NT2RP2005031 1.54 1.54 4.99 3.94 4.53 3.92 NT2RP2005035 44.19 44.19 94.82 116.52 107.36 106.69 * + NT2RP2005037 4.28 4.28 5.87 7.91 10.26 7.09 * + NT2RP2005038 4.86 4.86 4.84 1.85 2.29 3.1 ** - NT2RP2005048 9.92 9.92 30.91 30.14 33.38 32.48 NT2RP2005069 16.01 16.01 34.88 21.99 20.63 27.64 NT2RP2005073 7.36 7.36 30.35 29.36 28.24 30.33 NT2RP2005097 2.39 2.39 5.6 5.27 5.2 4.6 NT2RP2005108 1.76 1.76 3.95 2.84 4.21 7.12 NT2RP2005116 3.53 3.53 5.96 6.27 5.42 5.89 NT2RP2005126 5.88 5.88 8.31 8.9 14.96 8.51 NT2RP2005135 5.08 5.08 5.22 4.65 6.59 5.47 NT2RP2005139 1.94 1.94 2.77 1.87 1.81 2.45 NT2RP2005140 3.82 3.82 4.86 12.39 6.72 8.55 * + NT2RP2005144 4.04 4.04 6.31 6.69 5.97 9.7 NT2RP2005147 2.23 2.23 5.49 5.61 6.15 6.25 NT2RP2005148 2.86 2.86 5.63 3.83 6.65 4.83 NT2RP2005159 3.92 3.92 5.6 4.94 6.38 7.41 NT2RP2005162 3.23 3.23 5.56 4.57 5.4 4.21 NT2RP2005163 9.15 9.15 20.61 24.53 28.92 23.77 * + NT2RP2005168 2.87 2.87 6.14 5.24 4.79 4.88 NT2RP2005181 2.64 2.64 5.42 3.4 2.11 1.98 NT2RP2005204 5.4 5.4 7.81 9.08 11.94 11.81 * + NT2RP2005219 4.61 4.61 9.64 7.09 10.28 8.7 NT2RP2005227 3.59 3.59 10.43 7.55 5.36 9.97 NT2RP2005237 26.49 26.49 94.81 86.96 105.8 93.92 NT2RP2005239 2.24 2.24 6.07 2.62 4.27 4.34 NT2RP2005247 10.63 10.63 37.59 35.58 46.1 46.95 NT2RP2005254 4.35 4.35 9.14 5.7 6.44 6.93 NT2RP2005270 9.06 9.06 17.44 10.82 9.28 17.11 NT2RP2005276 7.19 7.19 11.53 10.88 11.68 15.71 NT2RP2005287 7.98 7.98 11.97 8.37 7.7 13.36 NT2RP2005288 2.51 2.51 5.14 2.89 5.59 5.22 NT2RP2005289 4.26 4.26 8.48 6.68 9.08 7.49 NT2RP2005293 5 5 6.93 13.68 14.37 15.66 ** + NT2RP2005315 5.79 5.79 10.64 8.04 12.95 16.68 NT2RP2005322 5.05 5.05 15.42 18.91 11.33 22.43 NT2RP2005325 8.45 8.45 18.4 15.57 13.63 20.01 NT2RP2005336 1.71 1.71 6.68 4.18 5.74 5.3 NT2RP2005343 2.44 2.44 7.48 3.91 4.11 5.89 NT2RP2005344 3.39 3.39 4.83 2.37 2.67 3.32 NT2RP2005347 3.14 3.14 3.61 3.34 2.96 3.53 NT2RP2005354 6.49 6.49 11.79 10.37 13 11.38 NT2RP2005358 35.87 35.87 109.04 101.37 134.72 117.96 NT2RP2005360 2.93 2.93 5 3.59 4.97 3.84 NT2RP2005378 5.27 5.27 13.12 7.54 8.7 13.93 NT2RP2005391 3.06 3.06 5.41 4.21 6.76 7.72 NT2RP2005393 1.61 1.61 6.34 4.86 6.16 4.07 NT2RP2005407 2.59 2.59 5.71 4.28 5.65 4.64 NT2RP2005419 2.65 2.65 9.05 6.37 8.5 6.77 NT2RP2005425 5.63 5.63 18.38 15.27 18.89 15.46 NT2RP2005429 3.23 3.23 5.85 5.41 6.65 5.64 NT2RP2005436 4.65 4.65 10.5 7.02 4.28 4.97 NT2RP2005441 2.28 2.28 5.62 3.36 3.77 5.79 NT2RP2005442 24.92 24.92 40.66 34.62 25.56 41.66 NT2RP2005444 10.72 10.72 19.24 21.92 21.07 25.56 * + NT2RP2005453 2.79 2.79 7.44 2.63 4.09 3.15 NT2RP2005457 15.12 15.12 23.21 28.69 37.38 31.61 * + NT2RP2005458 2.47 2.47 5.27 3.55 4.16 4.95 NT2RP2005463 7.73 7.73 15.23 15.65 22.11 25.05 * + NT2RP2005464 5.96 5.96 11.91 9.22 4.67 10.35 NT2RP2005465 1.81 1.81 6.69 3.86 3.75 3.74 NT2RP2005472 10.98 10.98 32.59 28.21 27.9 25.85 NT2RP2005476 5.01 5.01 8.99 7.01 6.98 6.08 NT2RP2005490 7.51 7.51 21.09 18.18 25.55 23.45 NT2RP2005491 4.99 4.99 12.47 8.63 10.12 8.78 NT2RP2005495 3.56 3.56 5.77 3.38 4.55 4.3 NT2RP2005496 4.84 4.84 18.25 11.3 13.16 11.28 NT2RP2005498 2.92 2.92 7.45 5.18 5.03 4.98 NT2RP2005501 2.04 2.04 5.54 3.12 4.34 2.46 NT2RP2005506 124.3 124.3 217.82 139.27 121.83 104.81 NT2RP2005509 6.97 6.97 10.45 11.4 9.61 15.73 NT2RP2005514 3.93 3.93 6 4.06 7.05 4.39 NT2RP2005520 14.95 14.95 32.39 27.11 39.97 33.03 NT2RP2005525 6.19 6.19 7.01 7.81 7.68 4.79 NT2RP2005531 2.18 2.18 3.33 1.67 2.12 1.9 NT2RP2005535 4.66 4.66 9.09 9.34 7.79 8.91 NT2RP2005539 3.39 3.39 6.22 6.43 5.84 7.45 NT2RP2005540 3.2 3.2 7.15 4.79 5.58 6.59 NT2RP2005541 21.25 21.25 39.57 25.85 38.31 39.61 NT2RP2005549 2.69 2.69 7.66 6.72 4.85 7.11 NT2RP2005555 7.97 7.97 10.1 14.96 16.19 15.37 ** + NT2RP2005557 4.89 4.89 8.47 4.03 6.52 6.26 NT2RP2005581 3.93 3.93 9.61 6.32 7.95 6.89 NT2RP2005586 1.56 1.56 3.18 3.21 2.92 4.74 NT2RP2005597 2.77 2.77 2.93 2.98 4.1 3.84 NT2RP2005600 1.81 1.81 3.71 4.03 4.29 4.44 * + NT2RP2005605 4.93 4.93 14.29 13.17 15.14 15.75 NT2RP2005614 3.06 3.06 5.62 3.68 4.11 2.45 NT2RP2005620 3.47 3.47 6.26 3.6 3.92 3.11 NT2RP2005622 6.14 6.14 5.07 6.21 7.43 4.61 NT2RP2005632 5.72 5.72 10.95 11.57 10.42 14.89 NT2RP2005635 2.22 2.22 19.06 18.14 23.77 18.14 NT2RP2005637 1.53 1.53 8 3.73 3.71 4.14 NT2RP2005640 1.72 1.72 7.22 7.49 8.73 6.06 NT2RP2005645 4.68 4.68 11.8 10.61 11.47 9.67 NT2RP2005651 3.45 3.45 7.88 7.64 6.78 10.15 NT2RP2005654 4.08 4.08 4.14 3.02 2.52 3.8 NT2RP2005666 4.91 4.91 5.27 4.34 7.7 4.74 NT2RP2005669 7.15 7.15 7.95 7.05 11.14 8.21 NT2RP2005670 2.35 2.35 6.91 7.77 5.04 5.2 NT2RP2005671 3.12 3.12 7.83 10.77 8.9 9.78 * + NT2RP2005675 7.32 7.32 37.84 34.46 40.94 40.02 NT2RP2005683 2.56 2.56 7.01 7.16 5.19 7.16 NT2RP2005690 2.84 2.84 4.48 2.82 3.74 3.4 NT2RP2005694 4.07 4.07 5.49 3.77 6.26 3.54 NT2RP2005701 5.97 5.97 8.82 10.39 10.35 9.52 * + NT2RP2005712 5.67 5.67 5.28 4.83 7.94 6.33 NT2RP2005719 1.86 1.86 3.26 4.42 3.8 3.76 * + NT2RP2005722 4.16 4.16 11.13 13.39 15.7 15.94 * + NT2RP2005723 2.71 2.71 4.2 3.65 4.58 3.67 NT2RP2005726 2.55 2.55 4.13 2.86 4.01 3.22 NT2RP2005729 4.64 4.64 9.94 10.21 10.7 10.62 NT2RP2005731 3.05 3.05 3.39 2.51 2.16 1.27 * - NT2RP2005732 9.41 9.41 57.73 48.37 75.21 41.64 NT2RP2005737 10.75 10.75 22.28 27.16 25.02 17.59 NT2RP2005741 3.03 3.03 5.35 3.68 3.31 3.37 NT2RP2005748 1.86 1.86 5.94 3.8 3.72 2.95 NT2RP2005752 2.46 2.46 5.55 3.27 4.37 3.8 NT2RP2005753 8.45 8.45 14.76 11.12 11.69 14.45 NT2RP2005763 3 3 8.03 4.22 4.77 5 NT2RP2005767 3.72 3.72 7.79 5.55 6.75 6.29 NT2RP2005773 8.11 8.11 10.02 10.6 11.59 13.37 * + NT2RP2005774 4.25 4.25 12.72 6.86 12.24 14.61 NT2RP2005775 3.75 3.75 7.2 3.35 4.83 5.63 NT2RP2005781 5.11 5.11 9.88 9.82 7.19 12.94 NT2RP2005784 5.41 5.41 11.51 7.68 12.12 14.06 NT2RP2005789 3.98 3.98 11.24 7.89 9.52 8.86 NT2RP2005799 2.45 2.45 6.35 2.64 4.67 3.7 NT2RP2005804 9.01 9.01 25 27.85 27.32 30.57 NT2RP2005812 2.63 2.63 4.83 2.9 3.89 5.21 NT2RP2005815 2.48 2.48 3.15 2.38 3.21 5.2 NT2RP2005835 5.99 5.99 11.26 7.13 13.74 11.69 NT2RP2005841 2.32 2.32 10.04 4.89 7.43 11.23 NT2RP2005853 1.29 1.29 4.44 2.71 4.6 4.96 NT2RP2005857 7.37 7.37 9.87 13.46 7.93 20.27 NT2RP2005859 2.76 2.76 5 2.91 6.14 4.78 NT2RP2005860 1.41 1.41 3.54 1.45 1.89 2.22 NT2RP2005863 3.03 3.03 6.55 10.76 18.29 15.94 * + NT2RP2005868 3.86 3.86 5.85 5.1 6.3 7.77 NT2RP2005876 5.7 5.7 12.31 7.84 8.29 8.2 NT2RP2005878 2.26 2.26 8.44 5.25 4.95 6.32 NT2RP2005883 13.54 13.54 21.06 23.75 9.57 28.09 NT2RP2005886 7.18 7.18 50.05 51.13 62.09 50.14 NT2RP2005887 3.76 3.76 6.51 4.74 8.05 4.81 NT2RP2005890 4.17 4.17 9.77 11.87 17.13 12.15 * + NT2RP2005901 3.19 3.19 5.69 3.91 6.18 5.14 NT2RP2005902 3.17 3.17 4.33 4.78 4.77 6.25 NT2RP2005908 3.09 3.09 7.86 4.89 3.7 6.34 NT2RP2005927 1.77 1.77 2.66 2.25 4.36 3.07 NT2RP2005933 2.5 2.5 5.59 6.4 4.77 6.42 NT2RP2005941 2.09 2.09 5.2 3.31 4.41 3.9 NT2RP2005942 4 4 6.86 3.08 4.59 4.64 NT2RP2005946 4.63 4.63 9.49 5.33 7.06 6.24 NT2RP2005970 5.44 5.44 14 16.16 22.05 18.9 * + NT2RP2005980 3.71 3.71 5.25 2.69 3.46 2.37 NT2RP2005994 2.99 2.99 6.76 4.28 3.28 5.14 NT2RP2006004 1.31 1.31 2.89 2.07 6.09 2.58 NT2RP2006013 1.38 1.38 4.91 3.1 5.07 4.92 NT2RP2006023 8.37 8.37 17.77 20 21.43 21.14 * + NT2RP2006028 5.03 5.03 10.23 7.47 9.89 9.71 NT2RP2006038 4.67 4.67 5.86 2.79 5.4 1.09 NT2RP2006042 8.3 8.3 7.22 6.63 5.89 6.3 * - NT2RP2006043 5.65 5.65 7.59 7.6 10.99 8.29 NT2RP2006052 1.48 1.48 4.48 4.13 3.12 4.54 NT2RP2006057 3.73 3.73 6.23 5.69 3.83 4.95 NT2RP2006064 4.16 4.16 7.73 5.86 6.81 9.08 NT2RP2006068 2.76 2.76 6.75 6.8 7.81 5.81 NT2RP2006069 1.46 1.46 4.94 3.56 3.95 3.3 NT2RP2006071 8.37 8.37 7.8 9.28 10.48 9.11 * + NT2RP2006090 6.62 6.62 5.78 3.27 3.55 3.64 ** - NT2RP2006092 3.78 3.78 8.3 6.18 8.04 7.07 NT2RP2006097 14.05 14.05 40.38 31.2 25.81 40.02 NT2RP2006098 1.94 1.94 4.27 4.52 4.61 7.65 NT2RP2006099 3.84 3.84 11.02 10.65 10.99 13.34 NT2RP2006100 2.87 2.87 5.78 3.63 7.31 5.19 NT2RP2006103 2.39 2.39 5.54 2.6 3.93 1.71 NT2RP2006106 6.48 6.48 21.51 18.05 24.81 22.3 NT2RP2006127 3.17 3.17 4.92 1.62 1.26 1.21 * - NT2RP2006134 4.25 4.25 4.41 6.08 6.7 5.47 ** + NT2RP2006141 3.91 3.91 7.94 7.45 6.04 9.08 NT2RP2006166 3.1 3.1 10.65 9.01 8.94 7.85 NT2RP2006176 2.15 2.15 4.26 3.95 5.73 4.69 NT2RP2006181 1.68 1.68 2.84 3.21 3.14 2.45 NT2RP2006184 8.85 8.85 17.16 20.8 19.95 17.1 NT2RP2006186 3.01 3.01 4.57 2.77 2.29 4.33 NT2RP2006196 5.24 5.24 7.21 5.25 5.23 4.16 NT2RP2006199 5.06 5.06 4.38 3.81 3.65 3.64 ** - NT2RP2006200 0.87 0.87 3.43 4.37 4.52 2.17 NT2RP2006210 20.08 20.08 59.85 75.37 70.55 96.59 * + NT2RP2006219 2.88 2.88 6.26 5.97 5.11 7.36 NT2RP2006224 3.7 3.7 7.55 9 7.7 8.93 NT2RP2006237 1.97 1.97 4.79 3.45 2.74 4.14 NT2RP2006238 3.9 3.9 6.33 4.2 4.69 3.93 NT2RP2006258 4.5 4.5 6.73 3.07 4.27 4.39 NT2RP2006261 7.32 7.32 3.98 2.04 3.19 7.69 NT2RP2006269 4.11 4.11 7.96 9.52 5.46 9.06 NT2RP2006275 3.67 3.67 30.36 23.46 35.36 25.14 NT2RP2006282 3.16 3.16 8.89 8.85 8.4 7.05 NT2RP2006302 5.69 5.69 12.68 13.12 12.4 11.87 NT2RP2006312 4.88 4.88 8.22 8.47 9.13 9.8 NT2RP2006320 4.27 4.27 9.87 6.42 9.32 9.69 NT2RP2006321 3.27 3.27 4.23 2.79 4.99 4.13 NT2RP2006323 4.1 4.1 2.59 2.39 3.6 1.83 NT2RP2006333 0.67 0.67 1.82 1.7 1.04 1.17 NT2RP2006334 2.24 2.24 4.02 4.57 2.72 3.54 NT2RP2006338 2.4 2.4 5.26 4.73 5.11 4.04 NT2RP2006339 2.24 2.24 2.94 2.47 1.93 2.06 NT2RP2006355 3.61 3.61 4.59 3.14 3.39 2.22 NT2RP2006365 3.3 3.3 4.44 2.42 2.6 1.3 * - NT2RP2006374 16.34 16.34 111.62 108.73 174.7 73.65 NT2RP2006393 4.93 4.93 7.68 7.38 8 6.95 NT2RP2006394 8.59 8.59 17.91 11.3 11.18 15.38 NT2RP2006400 2.25 2.25 4.51 2.08 3.58 1.95 NT2RP2006411 27.71 27.71 42.11 23.61 17.25 37.31 NT2RP2006429 2.22 2.22 7.3 2.82 5.3 2.21 NT2RP2006435 1.46 1.46 5.29 1.76 2.65 1.98 NT2RP2006436 2.33 2.33 6.43 4.33 5.28 3.75 NT2RP2006441 4.69 4.69 8.19 7.76 8.89 8.37 NT2RP2006447 2.41 2.41 4.78 3.18 2.63 3.87 NT2RP2006454 2.58 2.58 5.38 4.39 3.37 4.03 NT2RP2006455 3.79 3.79 7.14 2.91 4.62 9.23 NT2RP2006456 1.96 1.96 5.99 2.51 4.49 3.17 NT2RP2006464 5.44 5.44 8.28 4.47 8.85 7.9 NT2RP2006467 4.17 4.17 10 8.56 12.47 12.58 NT2RP2006472 5.05 5.05 6.84 7.24 6.92 7.37 NT2RP2006474 4.69 4.69 16.3 18.19 32.31 21.3 NT2RP2006475 2.5 2.5 9.54 6.14 6.86 7.66 NT2RP2006476 5.34 5.34 14.94 7.62 13.82 17.24 NT2RP2006501 2.44 2.44 7.28 4.6 7.45 7.74 NT2RP2006512 10.25 10.25 19.79 16.72 7.89 29.01 NT2RP2006526 2.09 2.09 5.19 2.24 2.78 2.31 NT2RP2006527 3.61 3.61 7.05 4.56 6.14 6.46 NT2RP2006534 2.24 2.24 4.49 2.08 2.95 2.73 NT2RP2006537 6.08 6.08 15.7 11.72 17.73 12.82 NT2RP2006543 7.83 7.83 14.8 6.52 5.4 6.88 NT2RP2006554 1.33 1.33 3.71 1.79 3.76 2.2 NT2RP2006565 3.78 3.78 8.91 5.79 8.42 7.55 NT2RP2006571 1.38 1.38 3.88 2.77 4.01 2.29 NT2RP2006573 2.1 2.1 4.02 3.05 3.6 2.41 NT2RP2006598 2.25 2.25 7.04 4.34 6.56 4.78 NT2RP2006601 24.92 24.92 35.13 38.45 45.47 31.69 NT2RP3000002 5.04 5.04 6.09 4.7 5.04 8.18 NT2RP3000011 1.82 1.82 5.9 2.59 1.85 2.22 NT2RP3000014 3.29 3.29 7.66 4.22 3.06 4.95 NT2RP3000016 3.42 3.42 7 5.29 6.56 6.11 NT2RP3000022 1.71 1.71 3.93 1.72 4.68 0.59 NT2RP3000024 3.74 3.74 7.03 4.31 4.92 4.06 NT2RP3000031 4.66 4.66 8.66 4 6.75 4.86 NT2RP3000034 3.76 3.76 6.24 4.44 7.13 3.23 NT2RP3000037 2.76 2.76 6.5 9.41 13.44 11.06 * + NT2RP3000040 2.04 2.04 5.96 3.21 3.46 3.56 NT2RP3000041 2.15 2.15 7.35 3.71 3.01 3.16 NT2RP3000046 1.95 1.95 4.42 3.67 7.11 3.84 NT2RP3000047 3.25 3.25 5.55 5.85 6.2 5.94 NT2RP3000049 2.54 2.54 6.94 5.26 7.78 3.58 NT2RP3000050 4.99 4.99 9.03 3.76 8.5 6.22 NT2RP3000051 5.99 5.99 10.69 8.51 11.19 9.72 NT2RP3000054 4.31 4.31 6.5 4.38 5.35 3.22 NT2RP3000055 1.98 1.98 4.76 3.81 2.67 3.96 NT2RP3000056 2.87 2.87 7.09 5.59 3.32 3.91 NT2RP3000059 2.54 2.54 5.1 1.89 4.07 1.6 NT2RP3000063 2.18 2.18 5.51 3.34 5.19 2.27 NT2RP3000068 3.76 3.76 24.22 25.83 37.88 23.13 NT2RP3000069 17.44 17.44 20.58 22 28.87 18.2 NT2RP3000072 5.9 5.9 6.18 4.96 5.39 4.19 * - NT2RP3000080 4.38 4.38 6.72 3.78 5.28 3.93 NT2RP3000085 1.9 1.9 4.84 5.13 4.66 5.5 NT2RP3000087 3.77 3.77 9.1 6.22 5.61 6 NT2RP3000092 1.92 1.92 3.6 2.72 3.2 2.52 NT2RP3000109 1.74 1.74 5.05 5.63 7.94 4.24 NT2RP3000119 4.66 4.66 14.27 11.29 13.7 14.28 NT2RP3000125 3.02 3.02 5.56 3.42 4.53 2 NT2RP3000131 7.84 7.84 14.37 16.23 19.96 12.93 NT2RP3000134 5.96 5.96 9.01 6.61 7.25 6.46 NT2RP3000137 3.88 3.88 6.48 5.58 6.3 6.11 NT2RP3000142 2.87 2.87 7.77 7.28 5.03 5.31 NT2RP3000148 1.84 1.84 6.28 4.9 5.04 5.34 NT2RP3000149 2.51 2.51 6.97 6.14 7.77 8.24 NT2RP3000163 2.16 2.16 6.17 3.27 3.9 2.5 NT2RP3000168 5.53 5.53 14.55 12.8 11.65 11.73 NT2RP3000169 3.74 3.74 6.01 6.03 8.47 5.72 NT2RP3000171 10.86 10.86 16.71 28.33 38.98 25.93 * + NT2RP3000172 0.86 0.86 1.53 1.66 1.2 1.46 NT2RP3000186 4.32 4.32 10.6 19.18 15.43 15.82 * + NT2RP3000197 1.22 1.22 3.66 4.03 4.29 3.39 NT2RP3000201 2.4 2.4 7.2 10.49 8.4 7.88 NT2RP3000204 2.16 2.16 4.44 3.88 4.1 4.25 NT2RP3000207 2.87 2.87 4.71 3 2.6 2.45 NT2RP3000216 5.38 5.38 10.1 5.87 9.5 5.73 NT2RP3000220 5.14 5.14 5.66 3.68 5.69 2.92 NT2RP3000221 2.18 2.18 5.45 6.26 6.63 5.93 NT2RP3000232 2.7 2.7 8.01 7.1 5.52 5.92 NT2RP3000233 1.55 1.55 6.01 6.9 5.91 4.06 NT2RP3000234 3.23 3.23 9.09 12.89 10.4 11.41 * + NT2RP3000235 1.57 1.57 3.3 2.35 2.92 1.38 NT2RP3000239 4.61 4.61 11.11 9.51 9.71 14.92 NT2RP3000247 3.25 3.25 5.82 2.92 4.04 1.96 NT2RP3000251 6.11 6.11 6.52 5.22 5.82 3.25 NT2RP3000252 3.73 3.73 7.99 7.61 8.53 8.4 NT2RP3000255 2.18 2.18 2.96 3.26 3.13 1.97 NT2RP3000262 6.72 6.72 9.43 11.67 7.95 9.13 NT2RP3000266 6.47 6.47 15.5 13.38 10.83 12.64 NT2RP3000267 2.71 2.71 4.04 2.9 2.64 3.03 NT2RP3000271 4.38 4.38 5.57 5.11 4.84 3.72 NT2RP3000278 7.84 7.84 56.85 48.55 82.07 42.57 NT2RP3000281 4.94 4.94 10.72 8.19 8.22 7.27 NT2RP3000292 5.63 5.63 14.1 9.17 6.77 6.93 NT2RP3000299 2.31 2.31 4.92 3.73 4.89 4.98 NT2RP3000304 2.15 2.15 3.48 2.85 3.36 1.64 NT2RP3000310 7.24 7.24 24.22 18.94 23.07 19.88 NT2RP3000312 2.99 2.99 8.16 3.31 5.25 3.87 NT2RP3000320 7.06 7.06 6.17 5.25 4.74 4.74 ** - NT2RP3000322 11.05 11.05 18.76 32.59 45.13 46.95 ** + NT2RP3000324 6.91 6.91 46.42 36.64 43.53 39.68 NT2RP3000326 1.95 1.95 6.17 4.02 5.75 3.53 NT2RP3000329 2.5 2.5 5.96 4.97 8.84 5.9 NT2RP3000330 4.1 4.1 6.18 4.62 5.53 6.12 NT2RP3000333 3.23 3.23 7.45 4.36 5.28 4.52 NT2RP3000341 8.8 8.8 12.85 14.81 18.59 14.41 * + NT2RP3000344 2.73 2.73 3.75 2.69 3.54 2.29 NT2RP3000345 3.09 3.09 3.57 1.65 1.97 2.66 * - NT2RP3000348 444.59 444.59 802.63 824.621016.01 909.68 NT2RP3000350 4.25 4.25 10.34 4.57 9.28 6.4 NT2RP3000359 9.53 9.53 24.44 8.54 11.36 16.62 NT2RP3000361 7.5 7.5 11.12 7.89 7.81 8.95 NT2RP3000366 7.38 7.38 14.27 9.52 11.84 16.13 NT2RP3000378 2.67 2.67 5.75 3.92 4.78 2.47 NT2RP3000384 5.42 5.42 10.88 9.52 13.1 9.28 NT2RP3000389 12.54 12.54 21.49 23.95 35.02 27.32 * + NT2RP3000393 3.74 3.74 6.16 5.03 4.53 4.77 NT2RP3000395 110.27 110.27 212 108.33 38.18 148.45 NT2RP3000397 2.83 2.83 5.28 2.51 5.26 3.31 NT2RP3000398 3.39 3.39 10.12 11.46 11.18 12.26 NT2RP3000403 3.22 3.22 9.39 10.1 8.2 8.44 NT2RP3000418 3.4 3.4 10.22 7.12 11.08 13.42 NT2RP3000424 2.86 2.86 9.43 6.25 9.52 6.86 NT2RP3000427 4.65 4.65 9.05 11.55 13.43 12.35 * + NT2RP3000431 2.05 2.05 4.93 3.43 3.26 3.93 NT2RP3000433 2.63 2.63 8.65 5.65 7.09 6.65 NT2RP3000436 11.39 11.39 20.93 18.76 9.35 18.86 NT2RP3000439 1.4 1.4 3.61 2.54 3.56 2 NT2RP3000441 3.88 3.88 7.4 7.56 7.92 6.39 NT2RP3000444 3.31 3.31 7.29 2.36 3.25 2.2 NT2RP3000448 4.45 4.45 10.15 4.05 6.54 3.93 NT2RP3000449 2.84 2.84 4.59 3.1 3.94 2.93 NT2RP3000451 1.76 1.76 5.12 3.7 5 2.96 NT2RP3000456 1.69 1.69 5.48 4.23 6.67 4.21 NT2RP3000460 18.87 18.87 36.67 24.52 25.24 26.25 NT2RP3000471 3.14 3.14 6.49 2.74 4.98 5.84 NT2RP3000477 19.96 19.96 23.67 28.98 17.78 32.78 NT2RP3000478 5.86 5.86 8.95 5.21 8.98 2.6 NT2RP3000481 5.48 5.48 5.76 2.76 3.61 1.52 ** - NT2RP3000484 3.51 3.51 4.26 2.32 2.55 1.76 * - NT2RP3000487 1.77 1.77 7.4 5.07 4.03 4.97 NT2RP3000512 3.29 3.29 17.7 15.17 15.9 14.52 NT2RP3000523 13.05 13.05 30.74 31.75 27.83 34.4 NT2RP3000526 3.07 3.07 7.38 5.18 6.31 4.64 NT2RP3000527 2.83 2.83 6.5 3.76 7.25 5.03 NT2RP3000531 2.9 2.9 7.71 5.11 5.51 4.69 NT2RP3000532 5.74 5.74 5.6 5.75 8.39 4.26 NT2RP3000542 6.23 6.23 8.1 7.21 7.3 6.39 NT2RP3000554 8.81 8.81 15.22 13.78 10.56 14.95 NT2RP3000561 1.21 1.21 3.51 3.11 2.76 2.25 NT2RP3000562 1.84 1.84 3.5 3.7 3.87 3.23 NT2RP3000578 1.56 1.56 2.54 2.54 3.37 2.36 NT2RP3000582 1.26 1.26 4.66 2.24 2.52 0.41 NT2RP3000584 2.82 2.82 6.52 3.2 2.5 2.02 NT2RP3000586 4.08 4.08 4.59 3.28 3.9 2.87 NT2RP3000590 5.69 5.69 4.61 3.78 4.35 2.57 NT2RP3000592 1.8 1.8 2.99 2.97 2.75 3.15 NT2RP3000596 2.27 2.27 4.89 4.5 3.33 3.03 NT2RP3000599 1.67 1.67 3.07 3.88 4.98 3.82 * + NT2RP3000603 6.09 6.09 39.25 40.43 44.88 35.89 NT2RP3000605 2.84 2.84 6.66 4.56 4.23 2.56 NT2RP3000607 5.35 5.35 7.59 5.74 8.46 7.55 NT2RP3000616 3.26 3.26 5.45 2.56 2.38 1.21 NT2RP3000621 5.18 5.18 8.48 10.28 10.29 6.01 NT2RP3000622 2.36 2.36 8.76 5.85 6.21 4.72 NT2RP3000624 1.53 1.53 3.19 3.97 3.06 2.78 NT2RP3000628 2.44 2.44 8.04 10.27 7.85 5.58 NT2RP3000631 4.71 4.71 14.95 22.82 16.45 14.2 NT2RP3000632 2.35 2.35 5.5 7.78 8.91 5.91 * + NT2RP3000638 6.95 6.95 17.93 11.8 11.6 9.97 NT2RP3000644 25.72 25.72 48.41 57.98 72.01 52.49 * + NT2RP3000645 5.85 5.85 10.48 9.84 12.55 8.43 NT2RP3000652 3.39 3.39 5.34 6.22 5.9 7.74 * + NT2RP3000658 2.26 2.26 5.01 6.16 4.24 4.86 NT2RP3000660 2.34 2.34 6.25 6.98 6.91 5.14 NT2RP3000661 1.98 1.98 4.49 4.06 3.87 3.1 NT2RP3000665 4.79 4.79 12.26 11.83 11.92 7 NT2RP3000676 4.46 4.46 7.55 6.65 7.81 5.42 NT2RP3000677 2.87 2.87 4.13 2.44 3.07 1.54 NT2RP3000681 19.85 19.85 30.12 32.94 41.51 34.34 * + NT2RP3000683 2.68 2.68 9.67 6.69 7.09 6.69 NT2RP3000685 1.7 1.7 2.5 3.63 2.36 3.44 NT2RP3000690 2.77 2.77 3.29 3.82 3.75 2.72 NT2RP3000698 10 10 22.49 25.66 17.08 27.43 NT2RP3000708 3.45 3.45 5.5 8.17 9.22 8.56 ** + NT2RP3000719 2.83 2.83 2.83 1.16 1.7 1.91 ** - NT2RP3000721 5.63 5.63 24.61 23.43 39.76 21.55 NT2RP3000728 3.33 3.33 2.57 1.4 1.64 1.05 ** - NT2RP3000730 2.06 2.06 5.04 2.76 4.23 1.86 NT2RP3000733 2.87 2.87 6.32 3.48 4.47 4.25 NT2RP3000735 1.74 1.74 4.22 1.81 2.22 1.26 NT2RP3000736 2.71 2.71 6.35 3.29 5.05 3.65 NT2RP3000739 13.76 13.76 12.16 18.05 9.37 20.19 NT2RP3000742 3.89 3.89 10.06 4.54 4.97 4.43 NT2RP3000753 2.29 2.29 3.9 2.17 2.65 6.3 NT2RP3000759 9.07 9.07 15.99 11.11 17.14 23.05 NT2RP3000789 1.58 1.58 5.76 4.89 4.23 3.69 NT2RP3000815 1.91 1.91 5.92 4.49 5.57 3.08 NT2RP3000818 4.35 4.35 11.29 6.64 10.49 8.27 NT2RP3000820 9.01 9.01 18.49 18.58 20.1 16.9 NT2RP3000821 2.13 2.13 4.83 3.28 5.19 2.02 NT2RP3000825 1.87 1.87 4.94 1.92 1.47 2.27 NT2RP3000826 4.04 4.04 13.59 10.86 13.8 12.94 NT2RP3000836 5.33 5.33 11.61 11.55 14.11 13.3 NT2RP3000838 319.2 319.2 741.74 710.2 743.55 1049.86 NT2RP3000839 2.35 2.35 6.67 4.53 6.38 4.36 NT2RP3000841 2.17 2.17 4.32 3.79 5.55 4.72 NT2RP3000845 3.96 3.96 8.89 5.76 6.71 7.85 NT2RP3000847 3.7 3.7 7.94 4.48 5.94 5.28 NT2RP3000848 2.84 2.84 8.34 5.36 6.81 6.3 NT2RP3000850 5.67 5.67 7.04 6.58 11.29 7.47 NT2RP3000852 3.27 3.27 3.17 4.02 5.23 5.8 * + NT2RP3000859 2.76 2.76 7.12 4.46 7.11 8.43 NT2RP3000861 2.58 2.58 10.51 6.13 10.36 6.43 NT2RP3000862 15.29 15.29 24.16 16.36 9.81 23.13 NT2RP3000865 1.58 1.58 4.26 2.54 4.21 1.83 NT2RP3000866 2.08 2.08 5.03 2.37 3.59 5.22 NT2RP3000868 2.2 2.2 7.09 3.04 3.84 2.28 NT2RP3000869 3.54 3.54 11.36 9.61 15.76 7.9 NT2RP3000871 1.75 1.75 3.79 1.81 3.24 1.94 NT2RP3000875 0.99 0.99 4.25 2.57 2.71 3.64 NT2RP3000895 2.54 2.54 5.56 2.84 3.55 4.93 NT2RP3000900 6.01 6.01 11.86 11.3 7.7 14.58 NT2RP3000901 3.67 3.67 7.03 4.11 6.39 5.3 NT2RP3000903 3.76 3.76 7.87 3.12 5.92 3.93 NT2RP3000904 3.83 3.83 8.67 3.05 4.87 3.16 NT2RP3000907 5.66 5.66 10.03 8.94 10.67 10.14 NT2RP3000913 6.04 6.04 15.01 17.87 25.57 17.37 * + NT2RP3000917 7.64 7.64 16.58 7.66 6.56 13.51 NT2RP3000919 1.99 1.99 5.15 3.5 4.3 2.68 NT2RP3000921 2.26 2.26 7.67 4.88 4.07 6.51 NT2RP3000942 2.66 2.66 3.89 2.68 4.12 2.63 NT2RP3000968 70.24 70.24 87.55 105.89 110.05 115.38 ** + NT2RP3000974 5.36 5.36 9.06 3.21 4.48 2.64 NT2RP3000980 5.77 5.77 5.77 2.09 4.14 2.26 * - NT2RP3000984 3.17 3.17 7.65 6.33 6.68 4.58 NT2RP3000994 2.09 2.09 4.88 2.4 3.14 3.37 NT2RP3001001 1.46 1.46 3.45 3.75 4.14 1.31 NT2RP3001004 3.37 3.37 6.52 3.51 5.63 5.01 NT2RP3001007 4.46 4.46 9.87 10.02 10.62 6.81 NT2RP3001012 2.78 2.78 5.4 4.99 6.83 3.65 NT2RP3001042 4.74 4.74 5.52 2.99 5.18 1.38 NT2RP3001044 6.26 6.26 7.12 7.16 6.76 4.92 NT2RP3001048 2.52 2.52 3.01 3.5 3.93 2.42 NT2RP3001050 1.79 1.79 4.99 4.68 5.94 4.7 NT2RP3001055 6.55 6.55 15.6 16.48 12.44 20.49 NT2RP3001057 2.79 2.79 10.84 5.57 6.05 5.67 NT2RP3001061 3.18 3.18 6.57 5.03 7.85 5.42 NT2RP3001069 6.03 6.03 14.95 18.49 17.53 15.08 NT2RP3001074 4.2 4.2 7.22 8.72 10 6.64 NT2RP3001078 5.11 5.11 7.29 7.51 8.72 5.18 NT2RP3001081 4 4 5.72 4.65 5.19 3.52 NT2RP3001084 2.7 2.7 7.92 6.85 6.71 6.23 NT2RP3001095 1.57 1.57 3.88 3.69 3.68 3.42 NT2RP3001096 2.52 2.52 7.33 16.78 8.08 18.7 * + NT2RP3001097 3.65 3.65 4.28 6.42 8.11 8.5 ** + NT2RP3001107 3.69 3.69 4.79 3.77 4.03 2.37 NT2RP3001109 3.2 3.2 5.5 6.01 9.56 7.26 * + NT2RP3001111 4.58 4.58 4.19 3.41 3.51 2.29 * - NT2RP3001112 12.61 12.61 18.48 25.73 29.85 24.61 ** + NT2RP3001113 1.21 1.21 2.59 2.47 3.24 2.19 NT2RP3001115 1.51 1.51 3.32 2.57 3.77 2.19 NT2RP3001116 1.01 1.01 2.66 2.55 4.4 2.91 NT2RP3001119 3.69 3.69 6.75 9.07 6.67 5.44 NT2RP3001120 5.02 5.02 8.24 8.85 7.87 6.71 NT2RP3001126 6.16 6.16 12.34 17.84 19.66 17.49 ** + NT2RP3001127 6.93 6.93 6.76 4.79 7.63 6.36 NT2RP3001133 3.95 3.95 4.95 3.95 4.16 3.62 NT2RP3001140 1.46 1.46 2.43 3.21 2.38 6.71 NT2RP3001147 3.16 3.16 6.96 16.08 14.49 13.84 ** + NT2RP3001150 1.99 1.99 4.32 4.06 5.68 3.76 NT2RP3001152 1.7 1.7 3.29 3.15 3.62 2.51 NT2RP3001155 2.95 2.95 4.35 3.68 4.35 3.58 NT2RP3001156 4.38 4.38 6.57 2.91 5.72 5.67 NT2RP3001159 5.38 5.38 10.5 7.87 10.86 7.25 NT2RP3001170 7.38 7.38 5.96 6.12 8.01 4.56 NT2RP3001176 3.49 3.49 10.75 6.27 8.23 9.49 NT2RP3001195 2.35 2.35 4.81 6.79 5.79 6.22 * + NT2RP3001209 3.47 3.47 5.98 5.96 4.64 5.22 NT2RP3001214 1.63 1.63 4.91 3.44 3.87 3.81 NT2RP3001216 3.58 3.58 6.38 6.25 4.33 3.6 NT2RP3001221 3.33 3.33 4.27 3.07 3.06 1.79 NT2RP3001226 5.96 5.96 29.04 21.93 31.45 17.76 NT2RP3001230 3.17 3.17 2.41 3.09 3.14 1.56 NT2RP3001232 1.8 1.8 4.72 2.36 3.7 2.85 NT2RP3001236 1.68 1.68 4.3 1.7 3.26 1.47 NT2RP3001239 1.58 1.58 5.21 2.81 4.31 2.01 NT2RP3001240 12.83 12.83 22.18 23.01 24.3 14.46 NT2RP3001245 3.53 3.53 9.88 4.08 6.36 3.39 NT2RP3001253 2.79 2.79 4.87 3.34 4.53 5.21 NT2RP3001259 6.62 6.62 11.97 12.33 15.62 11.83 NT2RP3001260 3.74 3.74 5.15 3.45 5.44 3.97 NT2RP3001264 2.2 2.2 10.29 5.99 6.92 6.38 NT2RP3001268 2.25 2.25 7.18 4.93 4.72 4.35 NT2RP3001271 7.06 7.06 16.29 13.07 12.27 14.24 NT2RP3001272 3.73 3.73 12.45 9.43 11.09 10.15 NT2RP3001274 6.08 6.08 8.09 6.72 6.35 5.11 NT2RP3001275 9.78 9.78 11.58 21.56 26.84 22.59 ** + NT2RP3001280 3.39 3.39 5.5 3.58 5.24 4.18 NT2RP3001281 3.15 3.15 3.89 3.08 4.48 5.14 NT2RP3001288 49.31 49.31 103.24 124.07 142.92 164.41 * + NT2RP3001297 6.39 6.39 42.01 37.04 42.75 41.14 NT2RP3001300 5.23 5.23 15.92 16.78 17.41 17.76 NT2RP3001301 2.91 2.91 6.59 3.96 4.58 3.9 NT2RP3001307 1.76 1.76 7.67 2.07 2.81 2.06 NT2RP3001310 11.55 11.55 17.04 25.54 26.07 28.13 ** + NT2RP3001318 2.11 2.11 3.4 2.49 3.37 2.37 NT2RP3001322 3.58 3.58 5.23 2.62 3.84 5.48 NT2RP3001325 2.7 2.7 8.39 5.82 6.82 5.58 NT2RP3001338 2.67 2.67 6.19 4.1 4.21 3.5 NT2RP3001339 2.53 2.53 5.64 3.08 4.89 2.91 NT2RP3001340 2.9 2.9 8.42 6.36 7.07 5.79 NT2RP3001341 2.26 2.26 6.97 5.1 5.62 4.73 NT2RP3001354 3.22 3.22 9.77 4.28 6.93 9.35 NT2RP3001355 1.9 1.9 5.41 2.65 3.82 2.74 NT2RP3001356 2 2 5.34 2.59 3.2 3.55 NT2RP3001359 1.09 1.09 4.05 1.63 2.5 1.75 NT2RP3001364 2.34 2.34 5.31 3.26 6.67 2.67 NT2RP3001373 1.12 1.12 3.22 2.1 3.74 1.71 NT2RP3001374 1.9 1.9 4.17 3.18 3.92 3.1 NT2RP3001383 3.84 3.84 8.96 3.92 6.65 3.85 NT2RP3001384 4.11 4.11 9.47 3.54 4.46 2.41 NT2RP3001388 3.98 3.98 8.79 9.48 10.99 9.4 NT2RP3001392 4.61 4.61 6.19 3.91 6.14 3.23 NT2RP3001396 1.7 1.7 6.39 4.04 4.66 4.53 NT2RP3001398 2.51 2.51 6.55 3.85 7.05 2.94 NT2RP3001399 4.91 4.91 20.67 15.86 16.12 12.44 NT2RP3001402 6.46 6.46 36.36 33.37 41.61 39.66 NT2RP3001407 6.96 6.96 19.16 13.69 17.65 12.35 NT2RP3001416 7.92 7.92 15.88 13.02 18.3 14.72 NT2RP3001420 5.33 5.33 6.4 3.27 3.64 1.8 * - NT2RP3001425 3.73 3.73 4.92 4.74 5.67 3.15 NT2RP3001426 2.39 2.39 6.08 5.45 4.45 5.11 NT2RP3001427 1.82 1.82 5.61 3.46 2.89 3.59 NT2RP3001428 2.42 2.42 6.29 5.69 4.81 3.77 NT2RP3001429 3.08 3.08 5.91 4.15 7.37 4.73 NT2RP3001432 2.14 2.14 6.61 3.72 4.44 3.58 NT2RP3001439 4.14 4.14 6.39 5.87 7.27 4.41 NT2RP3001441 6.45 6.45 12.63 11.13 14.61 11.2 NT2RP3001446 4.99 4.99 4.99 4.64 5.22 4.39 NT2RP3001447 2.72 2.72 5.21 6.64 5.14 6.33 NT2RP3001449 3.95 3.95 11.85 16.9 14.57 13.16 * + NT2RP3001453 1.84 1.84 3.66 3.5 4.4 2.81 NT2RP3001457 3.86 3.86 7.71 6.06 6.93 5.5 NT2RP3001459 2.39 2.39 6.03 2.64 2.78 1.17 NT2RP3001463 2.77 2.77 6.74 5.93 5.94 3.98 NT2RP3001466 2.87 2.87 3.56 1.19 1.43 0.78 ** - NT2RP3001472 5.74 5.74 4.02 3.7 4.85 4.32 NT2RP3001475 3.54 3.54 7.61 6.91 6.65 7.39 NT2RP3001479 2.54 2.54 6.66 4.37 5.69 5.16 NT2RP3001490 3.18 3.18 9.26 4.4 6.02 5.21 NT2RP3001492 4.36 4.36 7.84 7.59 7.08 5.72 NT2RP3001495 4.14 4.14 3.85 2.75 2.92 1.76 * - NT2RP3001497 5.8 5.8 6.32 7.47 9.96 6.8 NT2RP3001501 5.36 5.36 5.52 3.12 4.49 3.43 * - NT2RP3001527 4.89 4.89 6.71 4.9 5.14 3.52 NT2RP3001529 1.51 1.51 3.5 4.12 3.95 4.18 * + NT2RP3001538 1.78 1.78 6.2 6.93 7.81 6.23 NT2RP3001539 5.81 5.81 14.5 15.19 14.15 16.47 NT2RP3001542 1.52 1.52 5.26 4.23 4.38 2.13 NT2RP3001549 4.75 4.75 11.12 14.57 11.37 13.44 NT2RP3001554 3.06 3.06 6.16 6.37 7.5 5.05 NT2RP3001560 4.96 4.96 5.73 4.67 6.35 2.36 NT2RP3001561 8.85 8.85 20.77 20.38 27.2 17.15 NT2RP3001564 1.54 1.54 8.24 6.43 4.53 5.96 NT2RP3001568 2.1 2.1 7.68 11.84 10.29 8.49 * + NT2RP3001575 3.94 3.94 7.24 6.39 6.97 6.16 NT2RP3001580 1.78 1.78 4.49 4.35 3.8 3.11 NT2RP3001587 4.38 4.38 8.74 10.75 10.04 7.77 NT2RP3001589 3.17 3.17 8.21 5.6 7.79 4.36 NT2RP3001592 4.52 4.52 21.6 19 32.62 14.54 NT2RP3001607 3.42 3.42 1.86 1.59 2.8 1 NT2RP3001608 1.05 1.05 3.59 2.41 1.73 2.31 NT2RP3001613 3.08 3.08 2.77 3.89 2.91 3.99 NT2RP3001619 4.31 4.31 8.15 7.69 6.45 7.62 NT2RP3001621 1.18 1.18 2.69 2.39 2.28 2.02 NT2RP3001629 2.58 2.58 3.28 2.68 2.41 1.7 NT2RP3001630 3.39 3.39 4.56 1.67 2.02 1.17 ** - NT2RP3001631 9.01 9.01 14.34 18.65 21.16 15.24 * + NT2RP3001634 4 4 5.29 4.51 6.89 5.11 NT2RP3001642 3.71 3.71 7.45 5.77 4.41 5.09 NT2RP3001646 1.56 1.56 3.7 0.89 2.79 0.95 NT2RP3001650 2.06 2.06 5.81 4.86 7.03 2.08 NT2RP3001667 4.66 4.66 11.91 6.93 9.95 5.13 NT2RP3001671 2.28 2.28 7.98 7.7 4.69 5.99 NT2RP3001672 1.33 1.33 4.55 1.66 1.47 1.72 NT2RP3001676 2.18 2.18 5.02 2.35 3.14 2.24 NT2RP3001678 2.86 2.86 9.24 5.12 5.14 6.03 NT2RP3001679 6.12 6.12 9.19 6.74 4.73 6.91 NT2RP3001682 1.82 1.82 5.09 4.45 6.18 3.35 NT2RP3001685 3.02 3.02 6.74 3.52 6.53 3.01 NT2RP3001688 3.01 3.01 9.42 5.46 8.21 6.43 NT2RP3001690 3.21 3.21 4.87 2.91 3.54 2.99 NT2RP3001693 5.69 5.69 10.93 16.59 18.34 16.12 ** + NT2RP3001696 2.28 2.28 3.63 1.77 3.68 3.39 NT2RP3001698 35.35 35.35 79.65 85.09 91.88 105.32 NT2RP3001708 4.82 4.82 8.78 6.34 6.95 9.01 NT2RP3001712 8.69 8.69 16.06 10.22 14.19 13 NT2RP3001716 1.44 1.44 5.45 2.14 3.42 2.31 NT2RP3001724 2.75 2.75 6 4.08 4.54 2.63 NT2RP3001727 11.73 11.73 38.73 39.17 49.36 31.26 NT2RP3001729 3.36 3.36 4.7 5.69 6.55 3.06 NT2RP3001730 12.54 12.54 26.52 12.53 19.94 16.4 NT2RP3001733 1.46 1.46 3.04 2.09 3.7 1.62 NT2RP3001737 3.02 3.02 7.12 4.62 5.49 2.78 NT2RP3001738 1.59 1.59 8.22 3.38 6.01 3.03 NT2RP3001739 3.26 3.26 5.25 5.63 6.1 2.51 NT2RP3001742 2.54 2.54 5.36 3.86 4.55 4.03 NT2RP3001751 3.61 3.61 11.54 9.94 12.82 8.76 NT2RP3001752 2.58 2.58 7.01 2.1 3.59 2.76 NT2RP3001753 5.73 5.73 9.48 10.83 15.3 13.69 * + NT2RP3001754 4.63 4.63 9.08 5.86 3.73 5.33 NT2RP3001756 4.66 4.66 7.36 9.37 5.75 8.03 NT2RP3001764 2.1 2.1 3.76 2.54 4.25 2.49 NT2RP3001771 2.63 2.63 3.2 1.52 4.14 1.22 NT2RP3001777 2.59 2.59 5.99 3.25 5.19 3.26 NT2RP3001782 3.52 3.52 14.68 6.47 6.63 6.47 NT2RP3001792 2.27 2.27 4.35 2.91 4.09 1.35 NT2RP3001799 1.76 1.76 5.18 5.71 6.36 5.68 NT2RP3001819 1.36 1.36 4.54 1.7 1.52 2.06 NT2RP3001829 21.63 21.63 43.14 35.64 17.14 24.87 NT2RP3001836 7.31 7.31 10.67 15.24 7.26 11.37 NT2RP3001839 18.86 18.86 31.77 31.97 19.23 17.53 NT2RP3001844 4.15 4.15 11.37 8.33 9.59 8.54 NT2RP3001848 9.61 9.61 52.04 44.52 74.75 43.87 NT2RP3001854 6.41 6.41 11.29 12.86 16.75 13.26 * + NT2RP3001855 2.27 2.27 3.94 1.87 1 1.74 NT2RP3001857 3.1 3.1 5.22 5.13 5.6 3.33 NT2RP3001858 1.53 1.53 4.45 4.41 6.04 2.97 NT2RP3001861 7.35 7.35 16.34 11.85 14.46 10.42 NT2RP3001866 4.35 4.35 9.63 5.52 10.42 7.93 NT2RP3001871 4.82 4.82 6.34 5.55 6.38 4.55 NT2RP3001874 6.8 6.8 9.73 7.72 11.19 6.14 NT2RP3001878 5.98 5.98 6.35 4.59 6.89 5.02 NT2RP3001885 3.21 3.21 5.3 5.65 5.25 4.42 NT2RP3001896 1.64 1.64 3.49 3.37 2.13 2.02 NT2RP3001898 9.03 9.03 17.69 14.71 8.69 11.94 NT2RP3001899 3.21 3.21 7.33 4.52 6.9 5.81 NT2RP3001901 4.58 4.58 9.18 8.19 9.44 9.21 NT2RP3001915 4.84 4.84 11.12 14.09 15.67 14.04 * + NT2RP3001926 2.8 2.8 4.88 2.47 2.45 1.65 NT2RP3001929 3.74 3.74 4.06 2.56 3.38 0.86 NT2RP3001931 4.63 4.63 5.26 3.9 5.62 2.98 NT2RP3001938 2.27 2.27 5.53 4.93 3.93 4.75 NT2RP3001943 3.27 3.27 5.36 5.77 6.5 5.56 NT2RP3001944 1.77 1.77 3.72 4.08 5.91 4.34 NT2RP3001945 4.25 4.25 12.2 11.86 11.78 6.11 NT2RP3001947 2.94 2.94 5.89 4.06 5.41 3.4 NT2RP3001949 4.21 4.21 8.9 10.49 11.08 8.08 NT2RP3001952 23.54 23.54 43.64 48.59 88.56 41.86 NT2RP3001954 5.06 5.06 3.68 4.34 4.79 1.85 NT2RP3001956 4.97 4.97 9.44 7.76 8.22 6.29 NT2RP3001967 3.78 3.78 7.74 6.7 5.37 5.66 NT2RP3001969 1.71 1.71 2.91 4.05 4.39 3.62 * + NT2RP3001976 2.25 2.25 4.67 6.22 6.25 4.84 * + NT2RP3001986 3.55 3.55 3.88 3.43 2.82 2.19 NT2RP3001989 3.76 3.76 5.23 2.86 3.58 2.54 NT2RP3002002 6.68 6.68 9.47 6.25 8.85 3.86 NT2RP3002004 5.02 5.02 6.23 3.79 5.74 3.55 NT2RP3002007 1.29 1.29 2.3 3.46 4.05 1.69 NT2RP3002014 1.38 1.38 6.23 6.04 6.24 4.21 NT2RP3002015 3.61 3.61 10.33 14.17 9.94 8.85 NT2RP3002033 1.54 1.54 5.03 7.29 5.03 3.65 NT2RP3002045 1.89 1.89 5.29 4.67 4.36 2.5 NT2RP3002054 5.26 5.26 8.12 6.27 9.17 5.42 NT2RP3002056 5.67 5.67 5.52 4.24 4.24 2.7 * - NT2RP3002057 4.35 4.35 3.5 2.87 2.41 0.81 * - NT2RP3002061 4.71 4.71 13.94 8.64 8.9 10.74 NT2RP3002062 0.8 0.8 2.42 3.58 3.26 1.11 NT2RP3002063 5.61 5.61 10.31 9.29 9.3 7.31 NT2RP3002064 2.6 2.6 3.37 2.72 3.74 2.52 NT2RP3002071 1.6 1.6 3.91 1.99 3.29 1.45 NT2RP3002073 6.47 6.47 9.55 10.45 11.13 8.64 NT2RP3002074 4.2 4.2 7.25 6.33 7.82 4.24 NT2RP3002075 7.58 7.58 11.93 21.64 30.17 18.15 * + NT2RP3002077 3.81 3.81 5.95 2.48 3.05 2.78 NT2RP3002081 4.25 4.25 7.55 13.22 12.62 11.13 ** + NT2RP3002086 3.86 3.86 9.77 5.59 8.66 6.95 NT2RP3002094 7.34 7.34 10.28 13.84 14.79 11.67 * + NT2RP3002096 1.98 1.98 4.53 1.28 3.12 1.73 NT2RP3002097 3.77 3.77 6.16 6.1 8.34 6.88 NT2RP3002098 1.61 1.61 4.3 1.04 1.8 1.46 NT2RP3002102 2 2 4.86 3.11 3.4 3.16 NT2RP3002106 2.74 2.74 4.98 2.83 4.9 2.51 NT2RP3002108 3.69 3.69 7.8 3.11 3.39 3.15 NT2RP3002109 12.49 12.49 32.04 31.61 27.15 25.12 NT2RP3002110 36.38 36.38 54.93 55.24 58.94 46.55 NT2RP3002113 11.15 11.15 13.99 10.66 15.22 11.44 NT2RP3002120 2.22 2.22 4.42 2.31 4.13 2.7 NT2RP3002121 5.93 5.93 14.39 13.38 14.39 15.06 NT2RP3002126 34.03 34.03 108.96 121.18 130.55 142.49 * + NT2RP3002128 4.06 4.06 8.23 3.36 6.87 3.92 NT2RP3002130 8.29 8.29 18.59 11.69 10.7 14.03 NT2RP3002133 14.24 14.24 18.31 10.06 8.3 19.51 NT2RP3002136 10.32 10.32 15.42 12.49 17.64 17.49 NT2RP3002140 3.13 3.13 6.35 6.15 3.9 4.16 NT2RP3002142 16.86 16.86 50.85 56.54 81.25 62.65 * + NT2RP3002146 4 4 7.22 5.14 9.31 6.56 NT2RP3002147 3.8 3.8 10.45 6.06 7.4 6.2 NT2RP3002151 5.62 5.62 10.64 6.27 4.43 7.33 NT2RP3002155 1.62 1.62 3.27 2.01 4.98 0.8 NT2RP3002156 3.15 3.15 4.82 2.55 4.08 2.42 NT2RP3002160 1.57 1.57 3.43 1.36 3.43 1.56 NT2RP3002163 20.86 20.86 55.1 35.13 44.03 32.6 NT2RP3002165 4.17 4.17 3.67 6.21 8.31 4.86 NT2RP3002166 4.04 4.04 10.53 7.76 8.79 5.58 NT2RP3002173 2.24 2.24 5.75 2.95 3.34 3.53 NT2RP3002174 8.41 8.41 15.8 13.21 7.82 14.77 NT2RP3002181 1.1 1.1 3.46 1.87 3.51 1.61 NT2RP3002185 2.69 2.69 4.51 2.94 4.35 2.61 NT2RP3002193 5.51 5.51 13.38 16.39 15.35 11.36 NT2RP3002204 5.66 5.66 12.49 17.04 24.14 18.95 * + NT2RP3002244 4.03 4.03 8.29 5.28 6.11 4.8 NT2RP3002248 5.42 5.42 11.1 8.19 11.78 6.52 NT2RP3002253 2.61 2.61 9.3 9.66 11.26 6.18 NT2RP3002255 11.07 11.07 26.56 22.78 11.53 20.93 NT2RP3002264 3.06 3.06 5.54 5.88 7.37 4.07 NT2RP3002267 1.26 1.26 4.33 3.1 4.65 1.82 NT2RP3002273 7.51 7.51 12.98 10.15 13.8 12.11 NT2RP3002276 5.22 5.22 7.89 3.08 7.68 3.48 NT2RP3002281 6.37 6.37 6.83 7.45 8.46 3.44 NT2RP3002286 3 3 4.79 3.54 4.34 3.88 NT2RP3002297 10.62 10.62 29.36 22.26 20.57 23.93 NT2RP3002301 5.73 5.73 13.24 9.47 7.55 6.21 NT2RP3002303 3.01 3.01 6.39 5.29 6.65 4.58 NT2RP3002304 2.66 2.66 7.17 6.3 7.3 4.91 NT2RP3002309 2.3 2.3 7.18 9.26 13 4.39 NT2RP3002311 4.54 4.54 6.67 3.17 4.02 1.83 NT2RP3002315 15.27 15.27 20.91 25.82 33.13 21.82 NT2RP3002319 2.37 2.37 5.06 3.07 3.51 2.38 NT2RP3002324 8.97 8.97 61.42 49.85 51.23 55.4 NT2RP3002330 4.74 4.74 8.33 10.31 8.24 8.15 NT2RP3002333 5.13 5.13 14.32 13.14 13.65 8.12 NT2RP3002337 2.61 2.61 5.14 4.8 5.57 4.87 NT2RP3002342 5.16 5.16 11.56 5.52 7.51 6.43 NT2RP3002343 3.38 3.38 7.29 5.8 7.03 4.13 NT2RP3002351 4.32 4.32 4.55 4.38 3.9 2.55 NT2RP3002352 6.3 6.3 8.01 4.4 6.76 4.31 NT2RP3002353 3 3 4.85 4.87 6.18 5.9 NT2RP3002362 5 5 11.74 15.86 11.03 10.49 NT2RP3002363 2.41 2.41 3.67 5.53 6.17 2.32 NT2RP3002377 2.61 2.61 5.47 6.8 7.31 4.73 NT2RP3002377 4.47 4.47 7.73 11.4 5.31 7.09 NT2RP3002394 5.58 5.58 7.35 7.82 10.17 4.46 NT2RP3002397 3.77 3.77 4.81 2.7 3.12 1.68 * - NT2RP3002399 4.61 4.61 7.69 14.65 13.02 16.16 ** + NT2RP3002402 2.84 2.84 6.99 8.94 8.7 6.99 NT2RP3002404 2.88 2.88 5.6 3.12 3.73 1.83 NT2RP3002410 4.85 4.85 15.65 17.05 14.13 10.65 NT2RP3002411 2.98 2.98 5.68 3.7 5.29 2.85 NT2RP3002414 5.62 5.62 9.35 10.28 6.81 7.92 NT2RP3002430 5.11 5.11 14.63 18.24 19.29 14.51 NT2RP3002448 5.4 5.4 4.6 4.35 5.25 3.62 NT2RP3002454 7.3 7.3 15.31 12.9 12.71 9.32 NT2RP3002455 4.62 4.62 12.11 14.31 9.11 13.25 NT2RP3002456 3.21 3.21 7.75 7.09 6.57 5.9 NT2RP3002462 2.79 2.79 4.16 4.94 6.17 4.79 * + NT2RP3002469 3.84 3.84 6.38 9.24 6.78 8.07 * + NT2RP3002470 6.7 6.7 14.71 17.86 16.99 13.48 NT2RP3002484 4.01 4.01 6.86 6.81 8.01 4.59 NT2RP3002491 3.62 3.62 4.1 2.05 2.51 1.46 ** - NT2RP3002494 79.24 79.24 131.02 118.47 163.2 105.2 NT2RP3002497 1.07 1.07 1.57 2.37 1.39 1.37 NT2RP3002500 1.23 1.23 1.13 2.72 2.02 2.07 ** + NT2RP3002501 5.25 5.25 8.49 8.45 8.11 9.69 NT2RP3002512 2.85 2.85 3.97 3.3 2.74 3.57 NT2RP3002529 3.94 3.94 7.5 6.59 5.14 5.85 NT2RP3002533 7.95 7.95 10.26 9.79 10.51 8.18 NT2RP3002539 4.39 4.39 4.32 5.66 6.61 2.85 NT2RP3002540 5.24 5.24 5.5 3.48 4.76 3.65 * - NT2RP3002543 3.44 3.44 7.17 4.93 6.21 5.31 NT2RP3002545 7.34 7.34 7.46 5.17 5.52 6.8 * - NT2RP3002549 3.27 3.27 7.8 4.98 6.11 4.54 NT2RP3002552 3.05 3.05 6.04 4.17 5.81 4.06 NT2RP3002558 9.54 9.54 9.39 9.93 4.26 11.27 NT2RP3002565 1.94 1.94 4.83 1.73 2.48 1.52 NT2RP3002566 3.62 3.62 7.02 4.03 8.51 3.65 NT2RP3002571 2.53 2.53 4.85 3.77 5.41 3.74 NT2RP3002572 2.98 2.98 5.28 4.75 4.74 5.21 NT2RP3002573 4.31 4.31 11.38 7.06 9.48 7.06 NT2RP3002577 1.57 1.57 4.61 2.71 2.32 1.9 NT2RP3002579 3.92 3.92 6.41 4.03 7.75 11.16 NT2RP3002582 5.02 5.02 7.17 11.51 14.07 8.45 * + NT2RP3002587 1.9 1.9 3.13 2.68 3.04 1.97 NT2RP3002590 3.16 3.16 5.65 9.06 10.39 8.06 ** + NT2RP3002602 3.02 3.02 4.24 3.95 5.85 3.77 NT2RP3002603 71.53 71.53 214.41 268.41 257.84 298.26 * + NT2RP3002621 1.95 1.95 3.42 2.13 5.13 1.85 NT2RP3002622 2.63 2.63 7.38 3.7 7.36 4.67 NT2RP3002624 2.29 2.29 7.4 4.04 4.9 3.64 NT2RP3002628 6.36 6.36 16.17 19.57 22.15 16.21 NT2RP3002629 8.96 8.96 13.58 15.4 18.26 15.57 * + NT2RP3002631 1.95 1.95 1.67 0.91 1.65 1.69 NT2RP3002647 4.04 4.04 4.01 5.44 7.16 4.6 NT2RP3002649 2.99 2.99 5.99 2.15 5.84 3.23 NT2RP3002650 3.32 3.32 11.62 4.98 8.53 6.88 NT2RP3002652 2.27 2.27 6.59 4.91 6.83 4.25 NT2RP3002654 3.05 3.05 7.5 5.58 5.4 4.2 NT2RP3002657 14.14 14.14 13.87 17.27 26.08 18.87 NT2RP3002659 1.92 1.92 6.01 3.91 5.78 3.47 NT2RP3002660 3.09 3.09 4.84 3.77 7.72 3.52 NT2RP3002663 2.39 2.39 3.33 2.54 3.13 2.84 NT2RP3002664 2.74 2.74 7.28 3.65 2.56 2.13 NT2RP3002667 2.92 2.92 6.59 6.63 5.46 5.35 NT2RP3002671 2.37 2.37 5.02 3.91 5.52 4.11 NT2RP3002682 6.34 6.34 20.62 14.37 17.64 21.7 NT2RP3002684 4 4 6.34 3.32 6.16 3.18 NT2RP3002687 3.25 3.25 6.22 2.7 3.87 6.41 NT2RP3002688 3.22 3.22 4.98 2.63 3.91 2.61 NT2RP3002698 2.2 2.2 3.99 3.07 4.28 2.38 NT2RP3002701 2.93 2.93 6.73 3.45 3.07 3.6 NT2RP3002705 2.17 2.17 8.01 4.36 8.76 4.72 NT2RP3002708 3.69 3.69 9.88 5.64 7.34 4.9 NT2RP3002711 6.67 6.67 7.85 7.77 7.56 6.69 NT2RP3002712 55.99 55.99 75.28 146.74 168.42 130.64 ** + NT2RP3002713 4.31 4.31 7.06 2.66 2.19 1.87 * - NT2RP3002721 5.77 5.77 10.06 11.06 16.94 8.96 NT2RP3002722 7.11 7.11 10.08 7.8 6.45 6.62 NT2RP3002723 42.31 42.31 75.85 60.39 46.74 58.76 NT2RP3002737 8.35 8.35 18.1 10.97 11.6 9.37 NT2RP3002738 1.9 1.9 6.13 3.09 5.23 3.54 NT2RP3002742 14.11 14.11 23.22 30.39 28.27 27.66 * + NT2RP3002744 4.09 4.09 5.24 3.92 4.92 1.71 NT2RP3002756 5.8 5.8 5.8 3.19 2.68 1.55 ** - NT2RP3002757 12 12 17.79 19.76 24.24 19.75 * + NT2RP3002758 21.11 21.11 42.35 44.47 63.91 36.38 NT2RP3002762 5.07 5.07 8.82 7.21 7.43 7.76 NT2RP3002763 1.62 1.62 4.86 3.76 4.99 2.18 NT2RP3002770 1.78 1.78 5.14 3.46 3.7 2.93 NT2RP3002771 17.04 17.04 39.53 24.93 40.21 34.4 NT2RP3002785 2.42 2.42 5.45 3.36 4.09 2.66 NT2RP3002790 4.65 4.65 4.22 3.16 3.57 2.33 * - NT2RP3002799 4.73 4.73 6.33 3.42 2.7 1.43 * - NT2RP3002801 4.14 4.14 3.59 3.6 3.22 2.49 NT2RP3002802 2.31 2.31 6.3 6.78 5.43 4.4 NT2RP3002810 2.98 2.98 5.41 7.44 12.32 13.27 * + NT2RP3002818 1.5 1.5 2.44 2.18 4.16 2.47 NT2RP3002821 12.8 12.8 33.14 26.1 35.81 23.02 NT2RP3002823 3.85 3.85 8.98 4.65 5.92 3.87 NT2RP3002825 5.47 5.47 13.04 13.47 19.19 7.12 NT2RP3002829 5.37 5.37 6.25 4.75 4.89 3.8 NT2RP3002831 4.01 4.01 6.13 9.07 8.77 5.19 NT2RP3002836 7.33 7.33 19.42 11.56 16.91 20.66 NT2RP3002845 4.17 4.17 6.63 7.87 8.6 8.45 * + NT2RP3002852 3.37 3.37 7.57 7.8 8.72 8.21 NT2RP3002861 3.82 3.82 6.4 7.34 7.35 4.63 NT2RP3002869 3.66 3.66 3.26 2.49 1.86 0.49 * - NT2RP3002874 11.25 11.25 21.44 25.33 31.95 25.54 * + NT2RP3002876 6.98 6.98 11.06 12.8 14.93 14.39 * + NT2RP3002877 4.7 4.7 5.96 3.3 5.24 2.53 NT2RP3002887 0.47 0.47 3.42 2.81 3.53 3.91 NT2RP3002900 6.46 6.46 19.64 21.86 21.54 22.3 NT2RP3002902 4.01 4.01 10.25 11.72 8.52 8.06 NT2RP3002909 2.61 2.61 6.19 6.67 5.38 3.93 NT2RP3002911 3.05 3.05 3.68 3.09 3.73 2.24 NT2RP3002948 4.09 4.09 4.81 2.73 4.44 2.07 NT2RP3002953 3.85 3.85 3.6 2.27 2.52 0.84 * - NT2RP3002955 6.55 6.55 3.78 1.93 2.47 0.86 * - NT2RP3002958 5.85 5.85 11.4 16.5 10.57 16.64 NT2RP3002969 4.28 4.28 8.27 12.91 7.49 7.33 NT2RP3002972 3.55 3.55 4.82 4.41 6.18 2.29 NT2RP3002978 1.48 1.48 2.99 2.61 3.7 1.49 NT2RP3002983 2.89 2.89 4.69 4.46 6.12 4.37 NT2RP3002985 4.23 4.23 17.87 13.64 20.26 11.12 NT2RP3002988 3.97 3.97 4.6 4.12 5.64 4.13 NT2RP3003000 3.11 3.11 3.46 2.46 3.2 1.51 NT2RP3003008 3.26 3.26 5.87 3.95 4.55 2.96 NT2RP3003012 3.43 3.43 6.06 3.9 4.96 2.79 NT2RP3003015 1.35 1.35 4.9 1.5 2.5 0.54 NT2RP3003018 2.15 2.15 6.09 3.45 7.24 2.59 NT2RP3003028 3.53 3.53 7.23 3.5 5.05 4.01 NT2RP3003029 111.75 111.75 149.73 175.13 159.77 181.4 * + NT2RP3003032 7.06 7.06 9.05 11.87 18.84 9.94 NT2RP3003041 2.07 2.07 1.88 1.61 1.41 0.69 NT2RP3003044 3.06 3.06 7.45 5.72 6.11 7.57 NT2RP3003047 3.09 3.09 5.16 2.4 4.67 2.06 NT2RP3003050 5.96 5.96 12.03 6.74 10.3 8.42 NT2RP3003053 7.46 7.46 18 14.42 17.14 13.72 NT2RP3003059 1.93 1.93 4.76 2.88 4.41 3.06 NT2RP3003061 2.8 2.8 8.59 5.49 5.68 5.16 NT2RP3003068 5.99 5.99 11.77 9.41 8.75 10.04 NT2RP3003071 7.22 7.22 10.77 10.39 14.52 10.39 NT2RP3003076 2.67 2.67 9.49 6.57 6.57 4.01 NT2RP3003078 1.5 1.5 4.12 2.09 4.52 2.43 NT2RP3003081 6.21 6.21 10.54 9.94 9.6 9.97 NT2RP3003090 1.49 1.49 5.95 3.28 3.57 3.25 NT2RP3003097 2.42 2.42 7.15 2.71 3.72 2.93 NT2RP3003098 2.75 2.75 4.22 2.73 3.43 1.73 NT2RP3003101 5.56 5.56 7.24 7.73 10.35 7.18 NT2RP3003109 16.11 16.11 27.38 27.36 41.03 21.91 NT2RP3003121 3.39 3.39 11.03 4.61 8 2.44 NT2RP3003133 2.09 2.09 5.78 4.93 8.58 3.96 NT2RP3003137 3.42 3.42 5.74 6.32 7.59 5.29 NT2RP3003138 2.36 2.36 5.27 5.26 5.7 3.74 NT2RP3003139 2.53 2.53 7.8 3.15 5.74 2.7 NT2RP3003145 5.08 5.08 32.56 25.8 29.74 19.72 NT2RP3003150 2.03 2.03 5.17 3.56 3.76 1.97 NT2RP3003157 2.52 2.52 8.34 6.4 10.1 4.94 NT2RP3003185 1.77 1.77 3.88 1.91 3.34 2.62 NT2RP3003193 2.62 2.62 5.75 6.03 4.59 2.65 NT2RP3003197 2.38 2.38 3.8 3.11 4.02 2.2 NT2RP3003203 11.82 11.82 14.35 16.85 10.17 15.27 NT2RP3003204 3.76 3.76 7.93 4.04 6.17 3.79 NT2RP3003210 14.48 14.48 75.3 58.97 84.6 68.66 NT2RP3003212 5.15 5.15 9.44 9.21 10.67 7.36 NT2RP3003213 4.16 4.16 5.68 5.15 7.02 5.44 NT2RP3003224 1.7 1.7 4.75 2.43 2.11 2.64 NT2RP3003226 3.25 3.25 5.68 6.57 5.94 3.63 NT2RP3003230 7.79 7.79 11.47 12.39 8.89 6.72 NT2RP3003235 7.61 7.61 10.79 7.77 7.73 6.89 NT2RP3003242 12.17 12.17 23.49 26.68 32.03 19.25 NT2RP3003251 5.61 5.61 9.47 3.73 4.95 4.08 NT2RP3003252 3.95 3.95 5.95 2.19 3.7 2.42 NT2RP3003258 4.92 4.92 7.89 19.94 24.95 15.47 ** + NT2RP3003260 4.54 4.54 12.34 13.46 11.52 12.68 NT2RP3003264 1.64 1.64 5.99 3.18 4.32 1.86 NT2RP3003273 2.18 2.18 4.93 4.57 3.58 1.72 NT2RP3003278 1.33 1.33 4 1.31 5.12 0.63 NT2RP3003280 9.85 9.85 23.11 18.18 19.52 18.19 NT2RP3003282 5.29 5.29 6.25 3.62 3.97 3.48 ** - NT2RP3003290 6.64 6.64 9.09 4.8 5.38 3.78 * - NT2RP3003301 4.01 4.01 5.73 4.31 4.59 3.23 NT2RP3003302 1.45 1.45 2.31 2.91 2.64 1.91 NT2RP3003311 2.45 2.45 6.76 15.72 13.09 11.55 ** + NT2RP3003312 1.81 1.81 3.35 3.73 3.87 2.41 NT2RP3003313 1.61 1.61 4.2 2.91 5.4 2.87 NT2RP3003327 1.62 1.62 6.24 4.81 4.95 3.34 NT2RP3003330 5.13 5.13 8.01 15.68 16.13 12.78 ** + NT2RP3003344 3.36 3.36 4.14 2.92 3.74 2.6 NT2RP3003346 3.81 3.81 4.83 4.38 4.05 1.24 NT2RP3003349 4.04 4.04 6.93 9.96 9.41 9.65 ** + NT2RP3003353 1.95 1.95 3.24 4.06 5.37 2.45 NT2RP3003354 5.09 5.09 13.72 16.29 12.02 13.5 NT2RP3003368 3.03 3.03 4.73 4.04 4.08 2.63 NT2RP3003375 4.1 4.1 7.4 7.41 9.67 6.62 NT2RP3003377 4.16 4.16 3.98 2.57 3.58 1.65 NT2RP3003384 5.77 5.77 4.55 2.83 3.43 2.56 ** - NT2RP3003385 4.55 4.55 3.12 1.9 2.36 1.47 * - NT2RP3003396 3.93 3.93 13.63 16.4 8.38 12.32 NT2RP3003403 1.62 1.62 2.54 3.24 4.73 1.92 NT2RP3003409 1.18 1.18 2.97 3.3 4.48 3.03 NT2RP3003411 4.59 4.59 15.42 14.11 15.42 10.96 NT2RP3003420 3.79 3.79 4.36 3.68 2.13 1.85 NT2RP3003425 3.25 3.25 6.71 5.85 7.25 5.49 NT2RP3003426 9.11 9.11 16.3 10.88 11.12 17.45 NT2RP3003427 5.95 5.95 10.09 9.15 13.58 8.03 NT2RP3003433 2.55 2.55 6.26 8.42 9.57 4.87 NT2RP3003437 22.12 22.12 49.85 51.81 44 38.77 NT2RP3003448 1.88 1.88 4.24 3.5 3.83 2.63 NT2RP3003455 5.23 5.23 12.16 11.8 9.96 8.44 NT2RP3003462 4.96 4.96 10.07 10.76 8.25 7.08 NT2RP3003464 3.79 3.79 5.03 3.01 4.76 1.2 NT2RP3003469 4.1 4.1 7.77 6.62 7.56 5.07 NT2RP3003473 22.06 22.06 36.6 54.82 69.25 56.46 ** + NT2RP3003474 8.26 8.26 23.04 13.23 12.04 13.52 NT2RP3003475 2.84 2.84 4.04 4.55 4.45 3.28 NT2RP3003490 2.7 2.7 5.81 4.21 4.43 3.12 NT2RP3003491 2.26 2.26 3 2.14 2.75 1.26 NT2RP3003493 11.75 11.75 30.77 34.59 28.9 34.45 NT2RP3003500 4.93 4.93 5.26 4.99 7.46 3.65 NT2RP3003527 2.73 2.73 3.09 2.42 2.92 1.72 NT2RP3003532 2.7 2.7 1.81 2.14 3.33 2.13 NT2RP3003535 3.14 3.14 4.37 1.92 3.4 2.19 NT2RP3003536 3.04 3.04 5.95 3.45 5.2 4.97 NT2RP3003543 2.61 2.61 6.24 3.21 4.81 3.83 NT2RP3003549 1.43 1.43 6.66 2.18 4.07 1.55 NT2RP3003552 1.8 1.8 5.76 0.64 0.84 1.58 NT2RP3003555 4.4 4.4 14.14 12.16 17.43 16.23 NT2RP3003559 2.81 2.81 6.7 3.88 5.11 5.49 NT2RP3003564 3.11 3.11 5.9 2.24 4.6 5.25 NT2RP3003572 2.1 2.1 4.21 1.88 3.02 2.32 NT2RP3003576 5.88 5.88 10.15 11.32 8.98 9.22 NT2RP3003587 7.39 7.39 12.41 10.01 12.71 12.75 NT2RP3003589 15.33 15.33 22.45 23.89 23.75 26.58 NT2RP3003592 7.77 7.77 10.4 8.42 14.48 9.74 NT2RP3003593 8.16 8.16 13.62 13.47 13.84 110.49 NT2RP3003614 2.66 2.66 8.18 3.11 4.48 7.09 NT2RP3003621 1.64 1.64 3.91 2.1 3.68 2.96 NT2RP3003625 1.54 1.54 6.94 3.79 5.09 4.96 NT2RP3003627 6.73 6.73 20.05 16.23 13.97 25.71 NT2RP3003636 3.3 3.3 7.74 5.99 3.79 10.4 NT2RP3003642 7.12 7.12 12.2 12.85 13.15 15.83 NT2RP3003645 2.91 2.91 6.07 2.23 2.42 3.53 NT2RP3003648 2.88 2.88 3.71 2.17 2.44 3.13 NT2RP3003649 2.7 2.7 9.28 6.36 5.11 12.04 NT2RP3003650 2.65 2.65 4.25 4.38 3.16 4.09 NT2RP3003656 1.69 1.69 3.23 1.94 4.12 3 NT2RP3003659 2.76 2.76 4.56 2.14 4.8 4.88 NT2RP3003662 31.39 31.39 53.28 34.35 14.68 34.64 NT2RP3003664 3.56 3.56 6.5 6.18 5.45 6.55 NT2RP3003665 1.89 1.89 4.83 2.07 2.8 4.96 NT2RP3003671 2.88 2.88 4.33 3.03 2.6 4.29 NT2RP3003672 4.78 4.78 9.8 10.69 14.73 16.35 * + NT2RP3003673 4.98 4.98 9.42 5.35 3.05 4.12 NT2RP3003679 40.1 40.1 95.75 69.92 23.86 83.88 NT2RP3003680 3.13 3.13 5.38 3.96 4.58 5.88 NT2RP3003686 2.22 2.22 4.43 2.84 4.85 2.25 NT2RP3003689 4.05 4.05 9.69 5.94 5.63 8.27 NT2RP3003697 13.79 13.79 120.74 108.93 77.49 68.74 NT2RP3003701 2.7 2.7 5.17 2.58 3.05 2.57 NT2RP3003704 2.99 2.99 6.96 7.09 7.61 6.96 NT2RP3003714 1.39 1.39 4.25 1.68 0.89 1.14 NT2RP3003716 2.05 2.05 4.23 3 2.29 2.24 NT2RP3003721 1.83 1.83 3.27 1.85 3.45 2.18 NT2RP3003722 3.45 3.45 8.18 8.08 7.79 5.45 NT2RP3003726 3.5 3.5 4.9 2.77 4.51 2.32 NT2RP3003729 4.1 4.1 8.53 4.22 5.44 4.6 NT2RP3003731 5.06 5.06 6.98 4.19 3.54 7.45 NT2RP3003740 2.58 2.58 5.08 2.42 2.48 2.94 NT2RP3003746 3.63 3.63 8.14 6.7 5.94 6.59 NT2RP3003749 0.67 0.67 2.58 1.55 2.08 1.73 NT2RP3003754 3.32 3.32 7.31 4.66 5.87 5.81 NT2RP3003759 1.16 1.16 4.44 2.49 4.41 1.43 NT2RP3003764 3.97 3.97 7.08 6.85 7.41 5.06 NT2RP3003766 6.93 6.93 7.84 3.3 5.87 3.79 * - NT2RP3003767 11.19 11.19 16.8 14.83 21.08 16.97 NT2RP3003778 3.36 3.36 4.89 4.46 5.55 4.27 NT2RP3003779 4.05 4.05 15.26 13.02 8.74 10.52 NT2RP3003783 9.25 9.25 21.72 22.42 13.65 18.76 NT2RP3003787 2.15 2.15 4.65 4.41 4.74 6.37 NT2RP3003789 5.12 5.12 10.16 11.63 12.19 14.96 * + NT2RP3003795 1.48 1.48 6.48 4.09 2.82 2.24 NT2RP3003799 2.67 2.67 5.5 3.08 2.38 1.75 NT2RP3003800 4.36 4.36 5.92 4.14 4.57 6.91 NT2RP3003805 8.15 8.15 6.78 8.4 5.48 5.89 NT2RP3003809 1.94 1.94 7.2 5.83 5.4 4.82 NT2RP3003819 3.39 3.39 6.07 7.3 5.97 6.35 NT2RP3003824 5.69 5.69 10.69 14.08 14.85 13.32 * + NT2RP3003825 9.06 9.06 16.31 12.87 16.88 16.75 NT2RP3003828 4.7 4.7 14.38 13.36 15.69 14.55 NT2RP3003831 4.01 4.01 6.38 5.77 6.54 7.23 NT2RP3003833 5.12 5.12 7.5 6.44 8.88 6.96 NT2RP3003836 6.37 6.37 5.05 5.74 6.47 4.31 NT2RP3003842 2.7 2.7 9.08 6.84 6.51 7.09 NT2RP3003843 9.26 9.26 26.77 16.67 12.71 16.2 NT2RP3003844 20.38 20.38 46.56 42.84 27.94 44.32 NT2RP3003846 4.04 4.04 8.45 8.94 7.18 8.05 NT2RP3003849 2.27 2.27 2.68 2.67 2.73 1.68 NT2RP3003862 28.91 28.91 45.63 32 37.58 44.88 NT2RP3003870 4.76 4.76 4.81 2.54 2.93 2.05 ** - NT2RP3003874 21.46 21.46 20.88 33.11 47.25 36.44 * + NT2RP3003876 1.62 1.62 8.08 5.45 7.49 6.81 NT2RP3003880 1.74 1.74 4.63 5.31 4.66 4.73 NT2RP3003889 1.69 1.69 3.04 3.41 3.53 9.53 NT2RP3003891 1.88 1.88 2.98 2.56 3.19 1.37 NT2RP3003914 3.1 3.1 7.35 6.88 5.15 7.39 NT2RP3003915 5.03 5.03 8.44 9.52 11.35 8.6 NT2RP3003918 6.79 6.79 10.39 10.04 13.71 12.42 NT2RP3003920 6.9 6.9 9.13 8.31 10.22 8.96 NT2RP3003924 2.25 2.25 9.57 6.49 5.34 6.91 NT2RP3003932 1.41 1.41 3.85 5.17 5.26 3.85 NT2RP3003939 3.48 3.48 11.88 9.86 14.05 11.09 NT2RP3003940 11.34 11.34 27.33 23.54 20.59 23.06 NT2RP3003943 2.6 2.6 2.83 2.85 2.78 3.88 NT2RP3003959 3.52 3.52 6.96 6.54 5.93 5.49 NT2RP3003963 4.83 4.83 7.59 4.01 4.61 2.52 NT2RP3003965 11.14 11.14 13.85 18.75 20.67 17.22 ** + NT2RP3003972 26.1 26.1 40.32 22.13 17.98 38.48 NT2RP3003973 2.85 2.85 4.33 1.96 3.6 3.96 NT2RP3003979 5.89 5.89 12.53 6.92 8.49 8.84 NT2RP3003980 3.52 3.52 9.41 9.34 8.89 7.92 NT2RP3003982 4.2 4.2 4.63 2.44 1.6 4.61 NT2RP3003989 6.24 6.24 4.69 9.61 5.62 16.05 NT2RP3003992 2.13 2.13 4.89 2.47 5.12 4.8 NT2RP3004000 2.81 2.81 6 1.72 3.22 2.62 NT2RP3004001 11.38 11.38 19.94 11.62 11.37 21.11 NT2RP3004005 2.89 2.89 7.79 4.7 4.48 6.84 NT2RP3004013 2.23 2.23 7.2 2.66 4.87 3.57 NT2RP3004016 1.5 1.5 7.1 2.22 3.14 2.88 NT2RP3004025 4.02 4.02 7.69 7.48 12.19 9.01 NT2RP3004030 7.05 7.05 12.64 13.97 15.8 17.66 * + NT2RP3004041 5.65 5.65 11.38 10.48 9.57 19.81 NT2RP3004042 15.22 15.22 102.33 97.27 103.6 99.67 NT2RP3004044 2.13 2.13 6.51 5.14 7.21 4.22 NT2RP3004051 2.6 2.6 5.79 2.23 5.51 4.69 NT2RP3004052 7.1 7.1 11.22 5.63 4.98 9.78 NT2RP3004053 15.87 15.87 35.04 23.12 40.67 40.17 NT2RP3004055 2.38 2.38 5.33 2.98 3.3 4.47 NT2RP3004059 4.05 4.05 8.8 8.15 7.03 11 NT2RP3004063 5.13 5.13 11.23 8.78 11.27 12.33 NT2RP3004067 4.24 4.24 8.4 6.62 6.42 4.47 NT2RP3004070 3.58 3.58 9.92 6.26 4.4 5.47 NT2RP3004075 4.16 4.16 11.23 12.62 11.88 13.3 NT2RP3004078 2.6 2.6 5.25 4.94 4.19 2.79 NT2RP3004083 2.93 2.93 6.23 4.57 6.8 11.37 NT2RP3004084 4.65 4.65 20.29 6.18 8.56 5.32 NT2RP3004087 4.2 4.2 7.86 7.14 10.81 9.03 NT2RP3004090 4.11 4.11 6.42 9 8.19 8.61 ** + NT2RP3004093 2.38 2.38 7.49 4.07 3.51 4.47 NT2RP3004095 5.02 5.02 13.11 11.57 10.17 18.55 NT2RP3004102 3.32 3.32 5.59 5.25 4.27 3.21 NT2RP3004110 12.74 12.74 18.66 22.12 14.31 19.97 NT2RP3004119 3.3 3.3 7.71 3.91 4.08 3.73 NT2RP3004125 5.55 5.55 12.05 8.13 10.88 8.38 NT2RP3004129 4.62 4.62 7.38 3.36 2.95 6.08 NT2RP3004130 11.81 11.81 28.12 21.92 31.13 21.05 NT2RP3004133 4.51 4.51 12.95 14.62 8.94 16.81 NT2RP3004145 1.43 1.43 4.17 2.62 4.87 3.59 NT2RP3004148 2.67 2.67 7.07 5.26 6.24 4.5 NT2RP3004155 2.37 2.37 4.82 4.7 4.57 6.59 NT2RP3004165 17.94 17.94 29.96 29.58 31.82 39.18 NT2RP3004179 7.34 7.34 6.72 2.71 5.41 3.3 * - NT2RP3004185 5.2 5.2 5.53 2.76 2.76 1.95 ** - NT2RP3004188 4.77 4.77 10.82 7.74 11.35 7 NT2RP3004189 4.23 4.23 5.91 4.97 4.82 6.28 NT2RP3004190 2.6 2.6 5.57 5.84 4.36 5.26 NT2RP3004191 14.09 14.09 23.4 31.41 29.45 30.09 * + NT2RP3004202 2.04 2.04 4.56 4.16 4.42 2.3 NT2RP3004205 8.75 8.75 21.54 21.27 25.35 20.28 NT2RP3004206 4.5 4.5 9.74 5.14 6.37 9 NT2RP3004207 5.19 5.19 4.99 3.09 3.25 1.77 ** - NT2RP3004209 4.74 4.74 7.74 8.2 11.23 9.08 * + NT2RP3004215 1.86 1.86 6.7 3.96 2.41 4.55 NT2RP3004219 5.15 5.15 11.25 10.04 8.81 13.65 NT2RP3004242 4.65 4.65 10.36 9.8 10.19 14.56 NT2RP3004246 4.5 4.5 9.39 9.18 10.95 3.8 NT2RP3004253 1.89 1.89 4.85 3.64 4.99 2.8 NT2RP3004258 5.45 5.45 10.89 12.77 11.07 11.39 NT2RP3004262 4.26 4.26 5.71 2.63 2.99 2.01 * - NT2RP3004275 5.59 5.59 3.43 1.4 2.97 2.34 * - NT2RP3004282 5.45 5.45 68.08 51.29 52.72 53.57 NT2RP3004289 1.79 1.79 2.95 1.9 2.18 3.99 NT2RP3004294 2.74 2.74 6.02 6.95 6.93 7.24 * + NT2RP3004298 8.76 8.76 48.63 46.33 60.89 50.83 NT2RP3004309 3.3 3.3 6.46 5.2 5.22 5.31 NT2RP3004321 3.71 3.71 6.11 3.29 3.74 3.34 NT2RP3004322 5.61 5.61 6.86 6.06 6.43 6.56 NT2RP3004332 11.69 11.69 100.11 78.54 102.41 76.72 NT2RP3004334 1.49 1.49 6.97 8.56 6.06 9.06 NT2RP3004336 2.11 2.11 6.24 6.02 4.44 5.63 NT2RP3004338 3.09 3.09 8.41 10.22 9.52 16.47 NT2RP3004341 1.81 1.81 4.56 6.13 5.17 9.13 NT2RP3004345 4.1 4.1 8.68 9.3 9.63 8.48 NT2RP3004348 5.06 5.06 11.25 13.04 10.79 12.54 NT2RP3004349 5 5 7.5 4.89 7.75 5.76 NT2RP3004355 5.57 5.57 7.09 7.55 7.07 7.18 NT2RP3004356 5.76 5.76 21.51 11.29 15.14 15.56 NT2RP3004360 3.4 3.4 5.26 6.01 5.32 7.85 NT2RP3004361 2.6 2.6 6.26 7.67 7.3 8.87 * + NT2RP3004374 3.06 3.06 10.09 8.8 6.6 5.75 NT2RP3004378 10.48 10.48 18.57 28.26 24.09 34.81 * + NT2RP3004399 3.88 3.88 5.77 3.53 3.17 9.06 NT2RP3004405 4.07 4.07 6.77 3.03 5.52 3.93 NT2RP3004406 5.36 5.36 6.23 5.19 6.03 6.12 NT2RP3004411 5.93 5.93 13.28 8.08 6.39 9.51 NT2RP3004424 1.53 1.53 2.43 3.27 1.81 2.83 NT2RP3004428 3.03 3.03 5.36 5.07 3.82 4.09 NT2RP3004432 3.3 3.3 3.52 3.61 3.11 4.38 NT2RP3004434 3.42 3.42 8.41 7.28 9.09 7.99 NT2RP3004446 3.29 3.29 4.6 3.29 4.1 2.63 NT2RP3004451 3.2 3.2 6.01 3.89 3.38 2.48 NT2RP3004454 2.96 2.96 4.16 2.69 3.5 2.5 NT2RP3004466 3.5 3.5 7.89 5.25 3.85 5.61 NT2RP3004470 7.42 7.42 24.53 18.4 16.35 24.72 NT2RP3004472 2.49 2.49 4.4 3.97 3.84 3.88 NT2RP3004475 1.71 1.71 5.52 2.72 5.93 3.9 NT2RP3004480 14.12 14.12 17.04 18.94 10.5 18.82 NT2RP3004481 5.42 5.42 11.37 5.04 7.37 12.39 NT2RP3004490 2.66 2.66 8.45 3.92 7.03 8.25 NT2RP3004496 4.8 4.8 14.38 7.22 9.3 11.08 NT2RP3004498 6.39 6.39 21.39 16.86 15.11 18.92 NT2RP3004503 2.78 2.78 9.34 4.85 6.23 5.88 NT2RP3004504 3.91 3.91 11.09 6.05 10.67 11.52 NT2RP3004505 17.38 17.38 28.56 37.35 26.72 37.82 NT2RP3004507 1.57 1.57 6.6 2.52 5.52 1.68 NT2RP3004519 4.9 4.9 7.73 4.93 8.36 8.75 NT2RP3004524 10.04 10.04 29.21 26.88 26.43 29.62 NT2RP3004527 3.03 3.03 3.22 1.29 2.23 2.08 * - NT2RP3004534 3.08 3.08 10.44 5.58 12 7.38 NT2RP3004539 4.45 4.45 12.17 9.8 8.97 12 NT2RP3004541 2.65 2.65 11.06 5.48 9.44 8.25 NT2RP3004544 3.54 3.54 8.89 6.62 5.24 9.48 NT2RP3004551 3.46 3.46 6.75 6.6 6.6 6.98 NT2RP3004552 2.76 2.76 4.33 2.84 3.22 4.98 NT2RP3004557 5.68 5.68 8.73 9.74 15.44 13.16 * + NT2RP3004561 1.96 1.96 3.77 2.55 4.46 4.1 NT2RP3004566 3.09 3.09 11.55 7.2 10.05 8.79 NT2RP3004569 2.21 2.21 7.09 4.63 5.36 6.91 NT2RP3004572 4.37 4.37 6.83 7.08 5.55 7.07 NT2RP3004578 2.35 2.35 5.38 4.15 4.27 3.24 NT2RP3004584 4.76 4.76 28.36 34.99 37.13 30.29 NT2RP3004588 2.38 2.38 4.89 1.6 3.7 3.28 NT2RP3004594 2.25 2.25 5.9 5.67 6.49 8.94 NT2RP3004603 34.16 34.16 99.64 80.2 102.6 97.27 NT2RP3004612 4.71 4.71 12.17 5.3 3.36 5.34 NT2RP3004617 1.09 1.09 2.32 2.49 3.3 2.39 NT2RP3004618 4.61 4.61 5.9 2.49 5.21 5.9 NT2RP3004625 3.97 3.97 8.17 4.55 6.92 7.1 NT2RP3004635 4.76 4.76 7.83 1.52 2.86 3.47 NT2RP3004640 10.61 10.61 62.15 59.33 67.97 48.32 NT2RP3004642 8.04 8.04 29.31 22.82 26.12 25.12 NT2RP3004647 3.5 3.5 5.65 5.89 7.35 6.88 * + NT2RP3004652 1.76 1.76 10.37 4.2 3.71 4.34 NT2RP3004669 2.01 2.01 5.36 4.01 5.33 3.46 NT2RP3004670 5.04 5.04 10.58 12.4 9.19 14.23 NT2RP4000008 45.17 45.17 71.24 49.77 32.43 48.77 NT2RP4000018 11.64 11.64 14.61 11.69 14.8 14.87 NT2RP4000023 6.96 6.96 8.91 4.86 7.38 5.98 NT2RP4000025 16.2 16.2 22.16 26.22 29.89 24.7 * + NT2RP4000035 6.3 6.3 12.01 11.28 15.33 11.01 NT2RP4000041 14.46 14.46 34.8 22.01 17.41 23.68 NT2RP4000049 2.64 2.64 6.34 6.59 6.88 5.3 NT2RP4000050 2.24 2.24 6.87 3.54 4.48 4.05 NT2RP4000051 4.66 4.66 10.5 10.58 10.02 8.96 NT2RP4000063 20.51 20.51 33.5 26.77 31 18.33 NT2RP4000065 7.54 7.54 9.24 11.85 15.01 11.47 * + NT2RP4000070 6.63 6.63 5.29 3.79 4.54 3.84 * - NT2RP4000074 6.55 6.55 13.63 10.29 15.39 9.52 NT2RP4000078 3.41 3.41 9.55 12.2 11.66 12.56 * + NT2RP4000080 3.52 3.52 7.01 5.06 6.84 6.81 NT2RP4000099 128.86 128.86 236.22 149.44 161.1 211.56 NT2RP4000102 3.55 3.55 6.48 5.27 4.97 5.54 NT2RP4000103 2 2 5.47 2.57 2.85 3.96 NT2RP4000108 4.66 4.66 7.91 9.33 10.73 10.61 * + NT2RP4000109 18.89 18.89 22.84 19.87 24.15 16.14 NT2RP4000111 4.56 4.56 6.38 4.87 5.27 4.85 NT2RP4000112 5.62 5.62 10.14 12.45 8.7 11.81 NT2RP4000115 2.94 2.94 3.62 4.95 7.82 10.93 NT2RP4000129 2.18 2.18 4.58 3.02 5.04 5.03 NT2RP4000137 3.36 3.36 10.05 5.34 8.72 11.4 NT2RP4000138 7.21 7.21 10.91 17.75 20.19 19.17 ** + NT2RP4000141 3.25 3.25 6.1 5.22 4.9 3.57 NT2RP4000147 6.21 6.21 4.49 4.27 5.2 3.47 NT2RP4000150 5.96 5.96 6.93 7.33 10.41 7.06 NT2RP4000151 2.82 2.82 7.82 5.69 6.24 5.05 NT2RP4000157 73.27 73.27 222.87 169.53 97.5 173.8 NT2RP4000159 2.02 2.02 5.03 3.38 5.03 2.92 NT2RP4000163 5.21 5.21 8.74 10.89 9.18 6.63 NT2RP4000167 3.26 3.26 4.35 4.32 3.22 3.69 NT2RP4000171 5.72 5.72 7 5.72 7.45 5.03 NT2RP4000175 62.48 62.48 94.56 144.06 214.73 147.88 * + NT2RP4000180 17.17 17.17 106.15 88.61 123.6 81.8 NT2RP4000185 7.64 7.64 31.76 31.82 23.23 34.01 NT2RP4000192 1.04 1.04 4.78 4.19 3.6 3.05 NT2RP4000194 3.13 3.13 7.53 7.58 4.98 6.36 NT2RP4000196 6.81 6.81 43.94 35.57 46.56 41.91 NT2RP4000210 5.63 5.63 9.71 9.96 8.35 9.27 NT2RP4000212 5.59 5.59 8.88 8.57 8.41 9.08 NT2RP4000214 5.53 5.53 10.21 5.72 6.68 11.29 NT2RP4000216 8.89 8.89 7.36 7 12.63 10.08 NT2RP4000218 3.45 3.45 9.78 7.25 6.07 5.77 NT2RP4000223 21.18 21.18 177.28 121.8 125.75 125.3 NT2RP4000243 16.52 16.52 54.51 42.94 41.61 51.74 NT2RP4000246 17.75 17.75 37.97 26.43 11.42 27.5 NT2RP4000250 16.86 16.86 31.23 24.92 23.85 26.39 NT2RP4000256 4.38 4.38 8.45 4.99 6.44 4.67 NT2RP4000257 32.45 32.45 44.22 48.67 57.52 39.19 NT2RP4000259 7.07 7.07 6.96 8.48 13.07 9.08 NT2RP4000261 4.18 4.18 8.13 4.07 4.55 6.48 NT2RP4000262 8.36 8.36 11.02 7.11 10.05 7.64 NT2RP4000263 2.6 2.6 5.14 3.47 3.67 3.78 NT2RP4000280 5.84 5.84 11.62 9.05 11.58 14.23 NT2RP4000286 4.73 4.73 10.16 4.38 6.77 11.94 NT2RP4000290 5.77 5.77 5.42 3.18 3.19 5.5 NT2RP4000291 42.53 42.53 73.59 62.12 70.23 70.61 NT2RP4000301 3.31 3.31 20.59 22.93 34.62 26.63 * + NT2RP4000312 7.76 7.76 45.27 39.01 43.59 45.92 NT2RP4000321 3.73 3.73 8.16 7.88 7.14 9.75 NT2RP4000323 1.44 1.44 4.26 2.27 2.55 2.12 NT2RP4000324 7.77 7.77 16.76 8.33 10.2 11.08 NT2RP4000334 20.97 20.97 77.78 63.81 71.76 68.24 NT2RP4000343 2.48 2.48 5.54 1.57 3.16 2.38 NT2RP4000348 3.4 3.4 10.81 8.38 6.75 13.2 NT2RP4000349 1.78 1.78 0.83 0.37 0.72 2.48 NT2RP4000355 3.98 3.98 14.84 7.18 9.13 9.04 NT2RP4000356 8.3 8.3 22.64 9.22 11.44 21.13 NT2RP4000360 3.04 3.04 6.98 5.06 5.43 4.73 NT2RP4000367 2.18 2.18 3.72 2.04 2.58 2.83 NT2RP4000370 4.21 4.21 7.51 3.62 7.12 5.99 NT2RP4000373 3.33 3.33 5.18 3.19 5.23 2.95 NT2RP4000376 4.2 4.2 5.5 4.85 5.53 6.5 NT2RP4000381 1.97 1.97 6.46 4.31 7.01 5.59 NT2RP4000388 85.82 85.82 204.63 128.93 93.38 116.03 NT2RP4000390 12.16 12.16 94.1 78.97 76.6 82.02 NT2RP4000393 8.66 8.66 9.77 9.09 5.99 10.79 NT2RP4000398 5.51 5.51 26.52 22.08 28.3 26.61 NT2RP4000406 6.68 6.68 15.61 12.95 15.02 10.08 NT2RP4000407 6.17 6.17 11.52 9.41 14.74 9.13 NT2RP4000413 1.79 1.79 3.63 1.15 2.35 2.12 NT2RP4000415 7.59 7.59 26.11 18.6 21.68 21.68 NT2RP4000417 7.76 7.76 26.64 14.47 12.79 19.19 NT2RP4000423 3.52 3.52 7.56 7 6.98 6.46 NT2RP4000424 2.51 2.51 7.2 3.07 5.03 3.27 NT2RP4000447 10.3 10.3 64.21 64.91 71.82 68.48 NT2RP4000448 5.59 5.59 6.67 4.32 3.56 6.27 NT2RP4000449 5.67 5.67 20.48 14.2 19.45 14.67 NT2RP4000453 3.53 3.53 6.32 9.02 10.32 10.12 ** + NT2RP4000455 2.64 2.64 3.98 1.81 1.75 2.4 NT2RP4000456 12.57 12.57 21.7 14.7 9.86 13.58 NT2RP4000457 1.54 1.54 7.12 3.9 7.55 2.98 NT2RP4000461 5.7 5.7 9.84 7.65 6.41 4.6 NT2RP4000462 11.76 11.76 15.32 11.86 11.53 17.37 NT2RP4000463 10.2 10.2 52.59 50.66 69.3 48.36 NT2RP4000471 6.36 6.36 10.74 5.74 6.23 4.98 NT2RP4000472 3.97 3.97 4.41 1.27 1.27 1.66 ** - NT2RP4000476 27.14 27.14 52.56 74.95 94.93 65.35 * + NT2RP4000480 11.56 11.56 29.27 19.08 9.95 26.66 NT2RP4000481 2.29 2.29 4.76 3.73 4.16 4.33 NT2RP4000483 1.38 1.38 7.59 7.58 7.85 6.26 NT2RP4000487 1.54 1.54 4.9 2.26 3.17 0.91 NT2RP4000496 2.16 2.16 4.98 2.95 4.07 3.65 NT2RP4000497 17.15 17.15 22.33 34.9 44.46 29.9 * + NT2RP4000498 10.46 10.46 21.39 20.15 30.33 24.49 NT2RP4000500 2.43 2.43 3.21 2.03 1.49 1.39 * - NT2RP4000507 5.63 5.63 9.02 12.49 10.62 17.51 * + NT2RP4000515 12.85 12.85 88.89 90.3 101.29 96.12 NT2RP4000516 8.77 8.77 26.09 19.63 21.76 21.82 NT2RP4000517 3.22 3.22 5.73 4.69 5.89 4.79 NT2RP4000518 3.42 3.42 7.4 4.47 6.05 3.82 NT2RP4000519 2.9 2.9 5.76 2.18 2.22 1.77 NT2RP4000524 4.2 4.2 3.44 2.05 1.72 1.3 ** - NT2RP4000528 3.67 3.67 3.06 3.01 3.27 8.01 NT2RP4000537 35.4 35.4 62.6 36.23 30.93 44.52 NT2RP4000541 2.04 2.04 2.45 3.34 4.33 3.09 * + NT2RP4000543 2.93 2.93 8.94 7.96 9.72 8.75 NT2RP4000545 4.03 4.03 6.38 4.99 6.43 4.78 NT2RP4000546 3.34 3.34 5.93 5.53 4.9 6.03 NT2RP4000549 23.81 23.81 56.48 41.6 51.57 38.82 NT2RP4000556 7.36 7.36 13.04 14.69 15.54 12.07 NT2RP4000557 6.1 6.1 4.53 1.82 3.97 6.27 NT2RP4000558 30.12 30.12 94.28 68.16 57.01 73.2 NT2RP4000560 14.8 14.8 52.31 49.75 58.69 56.12 NT2RP4000568 1.72 1.72 3.83 5.6 6.08 4.46 * + NT2RP4000583 11.61 11.61 20.2 23.65 14.97 20.56 NT2RP4000585 3.04 3.04 4.14 3.12 2.55 3.24 NT2RP4000588 8.65 8.65 12.77 14.58 16.96 13.55 * + NT2RP4000590 24.89 24.89 41.97 41.86 50.81 32.65 NT2RP4000599 4.29 4.29 3.24 2.44 2.23 3.59 NT2RP4000603 14.08 14.08 33.32 31.06 21.01 29.12 NT2RP4000607 2.41 2.41 10.04 4.45 7.87 15.35 NT2RP4000614 6.14 6.14 15.21 15.57 12.53 15.19 NT2RP4000634 6.61 6.61 11 7.78 9.84 10.31 NT2RP4000638 3.59 3.59 7.77 8.45 5.8 4.73 NT2RP4000648 3.13 3.13 4.26 2.54 2.69 2.19 NT2RP4000657 9.94 9.94 15.38 15.95 18.93 14.49 NT2RP4000691 5.76 5.76 5.82 4.92 7.47 7.73 NT2RP4000697 3.74 3.74 8.5 5.55 6.56 6.12 NT2RP4000704 8.91 8.91 47.2 44.17 54.81 38.14 NT2RP4000710 40.22 40.22 98.85 90.4 59.28 83.71 NT2RP4000713 4.35 4.35 19.92 16.67 20.85 15.52 NT2RP4000724 6.29 6.29 12.5 8.19 9.81 7.83 NT2RP4000725 3.61 3.61 4 1.88 1.74 2.33 ** - NT2RP4000728 10.13 10.13 41.12 43.53 66.46 39.83 NT2RP4000737 4.07 4.07 2.15 3.63 3.09 3.28 NT2RP4000739 5.07 5.07 7.71 4.61 3.63 5.84 NT2RP4000749 2.4 2.4 5.29 2.59 3.97 1.68 NT2RP4000769 4.93 4.93 10.12 4.67 6.27 6.2 NT2RP4000774 3.34 3.34 8.87 5.12 6.63 4.27 NT2RP4000781 2.15 2.15 5.12 2.06 2.26 1.55 NT2RP4000783 6.81 6.81 15.16 13.48 15.44 12.67 NT2RP4000787 1.45 1.45 2.27 0.31 0.51 0.54 * - NT2RP4000788 3.58 3.58 23.26 16 18.3 18.73 NT2RP4000792 3.68 3.68 5.64 5.5 5.8 9.45 NT2RP4000809 43.7 43.7 56.09 46.75 50.47 81.62 NT2RP4000817 3.65 3.65 7.83 7.92 7.25 5.82 NT2RP4000821 31.34 31.34 38.66 28.32 33.11 25.22 NT2RP4000822 2.46 2.46 5.91 4.29 6.19 2.6 NT2RP4000823 697.74 697.741127.48 923.16 1026.8 947.85 NT2RP4000831 9.98 9.98 61.97 44.37 68.47 50.69 NT2RP4000833 3.19 3.19 11.26 6.73 7.19 11.91 NT2RP4000837 1.41 1.41 4.03 1.56 3.65 2.29 NT2RP4000839 12.23 12.23 97.13 79.71 85.74 86.06 NT2RP4000846 3.8 3.8 10.13 4.65 3.46 6.65 NT2RP4000848 4.63 4.63 10.74 8.65 8.58 6.07 NT2RP4000855 2.91 2.91 4.7 4 3.85 3.43 NT2RP4000863 3.08 3.08 4.33 3.11 5.3 3.78 NT2RP4000865 6.43 6.43 25.36 20.09 39.64 21.24 NT2RP4000873 9.64 9.64 88.25 63.22 69.65 71.33 NT2RP4000874 1.76 1.76 3.98 2.37 3.67 2.03 NT2RP4000875 3.31 3.31 9.24 6.88 6.52 7.19 NT2RP4000878 24.17 24.17 42.53 28.01 16.35 29.04 NT2RP4000879 2.56 2.56 5.1 2.95 5.29 2.62 NT2RP4000880 5.17 5.17 21.59 20.97 27.22 16.8 NT2RP4000891 81.07 81.07 192.57 252.29 351.53 221.08 * + NT2RP4000894 5.16 5.16 9.81 8.53 4.8 6.97 NT2RP4000898 0.86 0.86 2.74 1.88 2.14 1.64 NT2RP4000899 9.63 9.63 29.48 24.01 20.85 23.95 NT2RP4000907 2.14 2.14 3.58 1.74 4.04 0.81 NT2RP4000908 4.62 4.62 9.67 7.51 5.9 5.87 NT2RP4000910 14.4 14.4 104.68 124.04 197.74 160.9 * + NT2RP4000918 2.85 2.85 4.76 4.73 4.26 5.35 NT2RP4000925 3.9 3.9 5.53 2.81 3.15 1.86 NT2RP4000927 1.99 1.99 2.5 0.46 1.08 0.6 ** - NT2RP4000928 3.11 3.11 6.8 4.48 4.22 5.18 NT2RP4000929 1.44 1.44 3.68 1.94 2.86 0.84 NT2RP4000946 0.92 0.92 3.41 1.78 3.22 1.47 NT2RP4000947 1.71 1.71 3.51 1.94 3.31 1.79 NT2RP4000949 4.94 4.94 7.84 3.88 5.48 2.38 NT2RP4000955 4.17 4.17 6.34 2.07 2.86 0.54 * - NT2RP4000959 20.55 20.55 28.14 36.21 42.82 36.14 * + NT2RP4000962 3.4 3.4 4.24 8.33 10.09 4.53 NT2RP4000973 8.6 8.6 16.04 10.31 8.92 9.03 NT2RP4000975 2.18 2.18 5.84 3.29 3.05 2.62 NT2RP4000979 3.83 3.83 8.67 5.55 8.13 7.1 NT2RP4000984 1.61 1.61 4.31 3.15 3.93 1.85 NT2RP4000986 7.32 7.32 13.27 12.66 12.35 2.52 NT2RP4000988 5.74 5.74 8.37 4 5.2 2.63 NT2RP4000989 6.24 6.24 6.55 4.05 3.48 2.89 ** - NT2RP4000990 3.16 3.16 4 1.92 1.69 2.16 ** - NT2RP4000994 4.04 4.04 7.67 16.48 10.13 15.95 * + NT2RP4000996 3.54 3.54 7.49 6.77 6.52 7.38 NT2RP4000997 21.59 21.59 36.81 28.52 15.18 34.38 NT2RP4001001 5.53 5.53 9.17 16.66 18.38 15.09 ** + NT2RP4001004 1.71 1.71 4.88 2.84 3.09 1.37 NT2RP4001006 3.46 3.46 8.12 6.85 6.52 6.13 NT2RP4001009 9.3 9.3 10.45 15.44 20.46 8.25 NT2RP4001010 7.33 7.33 9.13 7.38 9.75 6.68 NT2RP4001013 23.29 23.29 50.16 30.87 28.1 30.91 NT2RP4001029 2.49 2.49 5.95 4.05 2.84 3.63 NT2RP4001036 7.55 7.55 13.55 9.11 11.51 13.16 NT2RP4001041 6.57 6.57 14.4 9.89 12.3 6.35 NT2RP4001042 4.34 4.34 8.11 9.44 12.5 8.79 NT2RP4001046 6.98 6.98 9.95 13.24 16.28 15.36 ** + NT2RP4001050 5.28 5.28 4.81 3.79 4.64 3.35 * - NT2RP4001051 6.48 6.48 8.44 5.43 6.82 5.26 NT2RP4001057 0.76 0.76 2.19 2.34 2.43 1.87 NT2RP4001063 1.48 1.48 4.39 3.34 3.53 1.8 NT2RP4001064 3.51 3.51 9.18 12.02 9.13 11.57 NT2RP4001067 4.42 4.42 9.77 10.96 9.63 6.6 NT2RP4001078 2.12 2.12 3.43 2.67 2.53 1.82 NT2RP4001079 5.3 5.3 9.35 8.51 8.02 8.98 NT2RP4001080 4.1 4.1 5.27 3.52 4.52 2.3 NT2RP4001086 5.08 5.08 4.19 3.93 6.64 2.85 NT2RP4001095 2.49 2.49 7.25 7.96 6.49 6.85 NT2RP4001098 0.92 0.92 3.38 3.87 2.95 3.41 NT2RP4001100 6.47 6.47 24.34 20.89 20.64 16.99 NT2RP4001105 3.13 3.13 7.23 6.51 5.58 4.61 NT2RP4001110 1.75 1.75 3.5 7.07 8.35 5.29 * + NT2RP4001115 9.95 9.95 17.68 20.6 18.48 15.31 NT2RP4001117 19.81 19.81 30.49 35.35 42.53 27.5 NT2RP4001122 6.06 6.06 6.09 5.17 6.25 3.27 NT2RP4001123 3.62 3.62 7.76 7.95 5.96 6.27 NT2RP4001126 4.36 4.36 11.28 10.87 9.09 8.04 NT2RP4001127 3.25 3.25 4.59 3.39 3.08 2.17 NT2RP4001138 2.46 2.46 5.8 3.41 2.56 1.62 NT2RP4001143 2.73 2.73 5.98 6.44 6.54 5.66 NT2RP4001148 3.72 3.72 6.76 3.77 3.03 2.05 NT2RP4001149 5.07 5.07 7.28 6.76 9.03 6.37 NT2RP4001150 3.8 3.8 3.17 3.15 3.7 2.88 NT2RP4001159 7.08 7.08 11.61 7.69 5.58 10.46 NT2RP4001162 3.77 3.77 6.14 4.07 6.06 3.41 NT2RP4001170 1.15 1.15 4.53 1.28 3.2 2.15 NT2RP4001174 4.16 4.16 12.27 7.91 11.95 5.02 NT2RP4001175 9.65 9.65 19.14 15.72 21.29 13.28 NT2RP4001176 99.19 99.19 161.51 174.03 241.92 194 * + NT2RP4001184 4.83 4.83 27.1 25.76 32.51 22.85 NT2RP4001198 21.66 21.66 48.22 29.54 29.17 38.54 NT2RP4001199 2.52 2.52 6.45 2.59 4.74 3.71 NT2RP4001206 8.25 8.25 33.2 25.92 32.07 25.48 NT2RP4001207 2.38 2.38 5.15 2.21 3.11 4.01 NT2RP4001210 2.73 2.73 5.2 3.62 4.26 2.64 NT2RP4001213 3.42 3.42 5.11 3.99 4.23 3.63 NT2RP4001214 3.34 3.34 4.3 3.51 3.76 2.16 NT2RP4001219 7.4 7.4 12.05 14.35 19.28 13.39 * + NT2RP4001228 5.26 5.26 9.63 12.15 15.74 20.07 * + NT2RP4001235 2.42 2.42 7.45 3.46 6.02 4.48 NT2RP4001256 2.11 2.11 4.24 1.66 3.41 2.66 NT2RP4001257 2.48 2.48 7.27 4.05 4.35 4.05 NT2RP4001260 3.16 3.16 5.79 2.52 3.86 2.92 NT2RP4001261 3.84 3.84 6.63 8.42 6.47 5 NT2RP4001274 22.92 22.92 38.08 25.02 31.56 21.25 NT2RP4001276 5.24 5.24 10.03 11.38 15.97 11.63 * + NT2RP4001283 20.72 20.72 122.55 87.44 93.43 86.47 NT2RP4001299 9.62 9.62 15.14 14.95 10.52 15.18 NT2RP4001313 1.45 1.45 3.26 1.72 2.96 0.97 NT2RP4001315 6.06 6.06 11.14 7.45 9.92 7.74 NT2RP4001320 14.6 14.6 42.74 32.02 38.13 29.24 NT2RP4001325 32.53 32.53 146.14 142.88 178.36 128.89 NT2RP4001336 6.69 6.69 40.75 38.55 46.66 32.11 NT2RP4001339 4.12 4.12 5.6 3.35 5.56 2.76 NT2RP4001343 10.46 10.46 83.37 54.71 61.01 60.06 NT2RP4001344 6.7 6.7 60.08 49.79 55.21 42.62 NT2RP4001345 1.65 1.65 6.68 5.64 5.7 3.87 NT2RP4001351 4.1 4.1 15.97 10.01 20.05 11.42 NT2RP4001353 2.8 2.8 5.91 1.63 2.94 1.86 NT2RP4001355 2.57 2.57 8.67 1.83 3.12 2.08 NT2RP4001367 10.64 10.64 17.66 11.92 17.06 13.16 NT2RP4001372 2.26 2.26 3.82 2.1 2.06 2.07 NT2RP4001373 8.86 8.86 16.4 10.99 8.59 11.48 NT2RP4001375 2.71 2.71 6.06 4.91 7.42 2.94 NT2RP4001379 1.74 1.74 3.52 2.34 4.67 1.38 NT2RP4001381 5.6 5.6 12.51 12.8 12.66 8.27 NT2RP4001386 6.39 6.39 14.52 14.77 20.11 12.32 NT2RP4001389 7.28 7.28 8.66 5.43 9.25 4.09 NT2RP4001396 5.76 5.76 6.42 2.83 4.61 2.12 * - NT2RP4001407 2.92 2.92 2.98 3.07 2.04 1.76 NT2RP4001409 13.6 13.6 28.28 8.87 5.85 8.84 NT2RP4001410 33.56 33.56 61.26 40.57 18.92 37.8 NT2RP4001414 16.59 16.59 37.89 14.29 21.3 16.8 NT2RP4001424 3.55 3.55 8.85 7.99 10.45 7.41 NT2RP4001433 3.85 3.85 6 8.39 9.79 3.38 NT2RP4001438 9.95 9.95 27.94 46.22 53.63 30.76 * + NT2RP4001442 4.33 4.33 4.97 3.3 3.41 2.64 * - NT2RP4001447 4.42 4.42 4.69 5.08 5.51 3.41 NT2RP4001466 3.74 3.74 5.45 7.38 3.23 5.57 NT2RP4001467 21.67 21.67 58.89 54.18 44.07 55.8 NT2RP4001472 8.05 8.05 12.19 11.7 11.76 11.97 NT2RP4001474 2.83 2.83 4.81 3.2 5.73 1.98 NT2RP4001483 1.48 1.48 4.33 2.61 3.7 1.19 NT2RP4001488 21.03 21.03 32.41 39.07 46.9 33.42 NT2RP4001492 4.18 4.18 6.73 3.21 3.81 1.91 NT2RP4001498 4.3 4.3 2.43 2.95 3.52 2.13 NT2RP4001502 28.2 28.2 57.38 27.65 34.81 41.83 NT2RP4001503 3.83 3.83 6.74 5.51 4.1 3.37 NT2RP4001507 2.39 2.39 3.69 5.03 5.95 5.18 ** + NT2RP4001510 1.74 1.74 4.63 5.64 5.05 3.02 NT2RP4001516 3.54 3.54 4.16 2.52 1.9 1.27 * - NT2RP4001520 25.33 25.33 70.64 73.93 107.21 85.05 NT2RP4001523 5.57 5.57 9.99 8.4 7.79 6.19 NT2RP4001524 6.1 6.1 10.17 8.92 11.45 5.98 NT2RP4001529 29.8 29.8 74.89 59.39 60.69 55.29 NT2RP4001531 2.88 2.88 10.96 8.63 11.05 7.81 NT2RP4001546 143.48 143.48 388.31 316.63 215.6 309.45 NT2RP4001547 9.05 9.05 26.31 28.76 23.06 18.81 NT2RP4001551 2.27 2.27 3.93 3.87 4.08 2.02 NT2RP4001555 2.95 2.95 5.8 4.14 3.58 1.74 NT2RP4001567 6.54 6.54 6.88 5.82 7.12 5.68 NT2RP4001568 7.58 7.58 11.65 10.02 19.33 12.97 NT2RP4001569 15.49 15.49 41.42 32.56 40.11 27.18 NT2RP4001571 5.75 5.75 13.28 9.06 7.43 8.13 NT2RP4001574 8.5 8.5 19.03 15.54 17.52 15.29 NT2RP4001575 2.46 2.46 5.86 5.71 5.53 4.24 NT2RP4001578 17.21 17.21 45.64 52.76 53.63 40.92 NT2RP4001592 9.76 9.76 13.68 14.13 19.64 11.68 NT2RP4001593 9.4 9.4 18.11 22.12 27.3 18.04 NT2RP4001605 5.97 5.97 4.78 4.1 7.77 4.66 NT2RP4001606 2.9 2.9 8.34 6.01 3.51 6.75 NT2RP4001607 2.04 2.04 5.24 4.57 3.26 3.78 NT2RP4001610 1.74 1.74 2.42 2.6 2.48 1.7 NT2RP4001614 2.17 2.17 7.19 5.38 4.34 6.86 NT2RP4001623 2.38 2.38 5.26 2.43 2.65 2.02 NT2RP4001626 9.48 9.48 11.67 18.67 23.9 19.44 ** + NT2RP4001634 2.74 2.74 4.93 3.67 5.24 4.26 NT2RP4001638 3.41 3.41 3.03 2.36 2.11 1.87 ** - NT2RP4001644 7.86 7.86 33.73 24.36 26.04 24.99 NT2RP4001646 11.61 11.61 15.02 7.42 10.74 11.21 NT2RP4001656 3.75 3.75 5.23 2.89 4.51 2.07 NT2RP4001666 1.99 1.99 4.68 3.26 6.25 2.02 NT2RP4001670 11.74 11.74 15.51 12.45 7.09 8.31 NT2RP4001677 28.27 28.27 42.75 42.01 45.48 47.53 NT2RP4001679 8.82 8.82 33.83 33.23 51.5 29.78 NT2RP4001695 7.71 7.71 12.76 15.66 20.35 12.87 NT2RP4001696 2.64 2.64 5.45 3.13 3.92 3.72 NT2RP4001699 3.58 3.58 8.03 3.18 4.12 4.42 NT2RP4001717 2.79 2.79 7.03 3.29 5.84 4.15 NT2RP4001719 3.59 3.59 9.11 7.6 9.27 6.28 NT2RP4001725 2.27 2.27 4.79 2.28 5.07 1.43 NT2RP4001726 7.07 7.07 11.18 5.85 6.91 4.98 NT2RP4001730 3.11 3.11 12.82 11.96 19.81 16.3 NT2RP4001739 2.83 2.83 5.83 5.79 6.55 4.98 NT2RP4001741 7.25 7.25 15.93 9.28 12.42 10.97 NT2RP4001753 3.04 3.04 8.4 4.39 4.64 6.64 NT2RP4001760 4.32 4.32 6.6 7.79 7.73 12.96 NT2RP4001787 67.61 67.61 173.05 169.17 187.1 193.22 NT2RP4001790 2 2 5.29 3.42 2.97 2.58 NT2RP4001795 9.31 9.31 12.31 14.38 19.76 12.34 NT2RP4001803 3.35 3.35 3.6 3.94 4.78 3.67 NT2RP4001805 2.64 2.64 3.57 3.64 2.47 2.95 NT2RP4001809 4.84 4.84 26.35 18.18 23.17 11.33 NT2RP4001817 11.55 11.55 19.09 9.5 10.78 12.71 NT2RP4001822 2.09 2.09 5.36 3.73 5.11 3.33 NT2RP4001823 1.91 1.91 3.95 1.14 3.34 1.24 NT2RP4001827 14.88 14.88 25.96 35.78 40.37 29.5 * + NT2RP4001828 9.76 9.76 34.37 27.78 34.21 26.3 NT2RP4001836 7.74 7.74 33.26 27.19 39.14 26.78 NT2RP4001838 1.59 1.59 7.49 2.09 4.5 2.71 NT2RP4001841 8.75 8.75 80.37 61.67 50.27 56.46 NT2RP4001849 1.9 1.9 4.55 2.51 5.08 1.58 NT2RP4001861 7.27 7.27 34.6 36.09 41.9 34.39 NT2RP4001877 6.59 6.59 8.44 12.87 9.04 14.1 * + NT2RP4001879 9.64 9.64 15.47 11.58 14.24 10.73 NT2RP4001889 5.09 5.09 10.66 6.68 11.25 8.91 NT2RP4001893 3.97 3.97 7.34 3.19 6.11 2.72 NT2RP4001896 3.18 3.18 6.86 5.38 7.87 4.92 NT2RP4001898 7.83 7.83 26.41 22.98 20.13 20.15 NT2RP4001901 1.73 1.73 4.69 4.08 5.87 2.69 NT2RP4001910 39.51 39.51 58.21 53.45 33.59 45.93 NT2RP4001925 4.1 4.1 10.21 6.69 6.32 6.12 NT2RP4001926 6.41 6.41 7.22 7.1 9.54 5.52 NT2RP4001927 6.26 6.26 9.97 5.83 8.13 2.82 NT2RP4001931 8.64 8.64 14.16 15.49 17.54 11.89 NT2RP4001933 38.49 38.49 87.13 96.81 133.51 91.22 NT2RP4001938 2.93 2.93 4.53 4.27 3.31 3.55 NT2RP4001942 13.44 13.44 27.12 31.34 24.8 18.71 NT2RP4001945 1.41 1.41 4 1.55 3.67 1.77 NT2RP4001946 1.97 1.97 5.67 3.04 3.96 1.66 NT2RP4001947 4.42 4.42 8.93 5.92 9.81 5.16 NT2RP4001950 4.13 4.13 5 2.25 2.84 1.34 * - NT2RP4001953 10.44 10.44 14.15 13.81 19.4 14.36 NT2RP4001966 2.44 2.44 2.41 2.51 4.26 1.52 NT2RP4001970 2.26 2.26 5.32 3.91 3.4 2.88 NT2RP4001975 8.56 8.56 20.03 18.32 13.05 12.02 NT2RP4001988 6.72 6.72 18.78 22.92 24.78 29.44 * + NT2RP4001996 5.27 5.27 12.83 10.65 16.35 12.42 NT2RP4002014 3.4 3.4 8.14 43.19 37.87 33.17 ** + NT2RP4002018 6.19 6.19 13.71 10.47 11.39 10.36 NT2RP4002035 5.35 5.35 5.95 5.4 4.17 2.54 NT2RP4002043 7.1 7.1 10.8 9.64 12.2 6.5 NT2RP4002046 9.74 9.74 20.08 21.94 15.28 17.11 NT2RP4002047 8.37 8.37 19.18 22.28 24.07 28.83 * + NT2RP4002052 5.78 5.78 10.36 9.02 9.36 9.37 NT2RP4002056 32.58 32.58 71.49 58.09 76.58 49.75 NT2RP4002057 6.37 6.37 11.06 12.13 13.58 7.41 NT2RP4002058 3.85 3.85 6.6 4.1 4.2 3.22 NT2RP4002064 5.93 5.93 4.39 2.6 4.16 2.07 * - NT2RP4002071 6.67 6.67 7.07 6.95 10.06 6.27 NT2RP4002075 1.16 1.16 2.11 2.27 2.35 1.27 NT2RP4002078 2.25 2.25 8.63 6.86 8.24 4.97 NT2RP4002081 8.11 8.11 26.15 18.73 18.78 19.42 NT2RP4002083 1.39 1.39 5.25 3.36 3.16 1.88 NT2RP4002099 3.26 3.26 4.73 2.84 3.56 2.51 NT2RP4002106 10.35 10.35 20.34 22.36 25.93 20.55 NT2RP4002111 11.7 11.7 12.37 19.77 30.44 17.72 NT2RP4002112 6.15 6.15 10.97 8.9 8.34 3.22 NT2RP4002116 12.6 12.6 47.19 37.43 41.25 28.65 NT2RP4002122 5.34 5.34 9.29 14.84 14.86 12.67 ** + NT2RP4002126 6.42 6.42 14.44 16.82 14.35 10.42 NT2RP4002133 7.56 7.56 20.82 29.17 26.14 21 NT2RP4002136 3.63 3.63 5.74 4.89 5.38 2.69 NT2RP4002139 26.89 26.89 31.12 60.65 61.92 32.88 NT2RP4002174 139.27 139.27 232.64 240.71 275.01 193.19 NT2RP4002185 7.77 7.77 13.2 12.36 19.06 11.58 NT2RP4002186 4.5 4.5 9.83 7.82 4.72 6.78 NT2RP4002187 15.42 15.42 32.13 26.94 19.84 21.17 NT2RP4002188 3.01 3.01 8.34 8.3 7.75 6.41 NT2RP4002199 1.85 1.85 3.73 2.6 2.91 3.78 NT2RP4002206 2.08 2.08 3.39 2.48 2.34 1.29 NT2RP4002210 3.13 3.13 4.75 2.02 2.86 0.98 NT2RP4002222 4.2 4.2 6.63 5.56 6.28 4.16 NT2RP4002241 7.97 7.97 8.24 10.82 11.75 7.19 NT2RP4002248 5.08 5.08 16.69 10.74 8.9 8.13 NT2RP4002250 1.54 1.54 3.22 0.73 1.69 0.56 NT2RP4002259 4.86 4.86 9.82 3.21 4.85 1.75 NT2RP4002268 16.62 16.62 29.54 28.9 28.18 25.68 NT2RP4002288 6.42 6.42 12.57 13.29 14.36 11.97 NT2RP4002290 7.55 7.55 7.61 7.96 7.67 5.87 NT2RP4002298 3.92 3.92 4.18 5.54 5.03 4.18 NT2RP4002306 2.38 2.38 5.79 2.97 5.77 2.64 NT2RP4002308 2.04 2.04 6.03 5.31 5.23 4.1 NT2RP4002336 2.71 2.71 6.33 3.71 4.19 4.63 NT2RP4002340 1.09 1.09 3.96 1.28 2.75 0.49 NT2RP4002361 2.77 2.77 5.78 3.73 4.03 2.48 NT2RP4002367 2.27 2.27 5.84 3.23 2.48 2.77 NT2RP4002368 9.87 9.87 17.2 18.26 19.27 16 NT2RP4002377 3.3 3.3 23.8 25.46 30.75 23.93 NT2RP4002408 2.22 2.22 3.87 3.75 6.37 4.11 NT2RP4002425 2.84 2.84 5.81 8.24 7.98 5.23 NT2RP4002432 12.33 12.33 85.4 61.06 72.53 67.82 NT2RP4002447 2.97 2.97 7.68 3.96 5.4 4.59 NT2RP4002451 5.48 5.48 6.2 5.84 5.85 6.83 NT2RP4002461 9.8 9.8 32.09 32.76 38.91 29.04 NT2RP4002486 3.5 3.5 6.71 2.47 4.15 2.87 NT2RP4002517 3.65 3.65 9.11 7.02 8.53 7.18 NT2RP4002556 4.29 4.29 3.91 5.68 10.03 6.41 NT2RP4002569 3.36 3.36 7.36 4.93 5.29 3.42 NT2RP4002587 2.26 2.26 4.19 2.8 3.4 2.02 NT2RP4002591 2.21 2.21 4.89 2.89 4.5 3.08 NT2RP4002607 1.43 1.43 3.34 2.87 4.63 1.58 NT2RP4002627 17.83 17.83 61.9 55.9 76.17 65.3 NT2RP4002628 7.28 7.28 15.48 14.53 23.95 12.54 NT2RP4002630 4.19 4.19 5.25 6.72 9.4 7.16 * + NT2RP4002639 9.43 9.43 70.25 52.38 77.24 57.28 NT2RP4002641 1.58 1.58 9.03 3.94 4.07 4.1 NT2RP4002658 114.62 114.62 166.93 76.49 34.96 109.83 NT2RP4002669 3.5 3.5 5.67 5.4 5.33 4.68 NT2RP4002677 6.24 6.24 9.41 10.14 7.99 13.62 NT2RP4002715 8.42 8.42 34.92 40.1 48.46 32.3 NT2RP4002750 2.6 2.6 8.29 1.68 2.04 1.33 NT2RP4002784 3.71 3.71 9.51 9.44 11.22 7.06 NT2RP4002791 4.91 4.91 9.44 4.88 9.76 5.33 NT2RP4002811 1.63 1.63 6.38 3.17 2.95 3.43 NT2RP4002830 4.26 4.26 7.45 3.9 5.9 5.46 NT2RP4002832 2.12 2.12 3.13 2.38 5.59 2.54 NT2RP4002850 5.07 5.07 12.04 14.36 12.63 8.06 NT2RP4002874 5.17 5.17 6.67 3.41 5.14 1.96 NT2RP4002884 28.81 28.81 49.75 43.57 74.75 52.87 NT2RP4002888 5.55 5.55 4.83 3.67 4.32 3.08 * - NT2RP4002891 5.48 5.48 15.79 13.16 19.42 11.91 NT2RP4002894 12.04 12.04 24.47 18.44 12.76 16.4 NT2RP4002896 5.54 5.54 12.2 8.96 6.18 7.78 NT2RP4002905 1.71 1.71 4.27 2.32 3.58 1.28 NT2RP4002907 5.11 5.11 7.62 6.94 10.72 1.41 NT2RP5003459 68.11 68.11 133.25 154.61 146.15 164.37 * + NT2RP5003461 7.34 7.34 10.14 10.85 14.36 8 NT2RP5003471 106.6 106.6 168.71 124.4 148.85 112.14 NT2RP5003477 2.71 2.71 2.62 2.59 2.33 1.9 NT2RP5003487 157.44 157.44 424.89 292.71 256.56 354.93 NT2RP5003492 3.1 3.1 4.91 5.25 6.17 5.91 * + NT2RP5003500 1.5 1.5 3.28 2.38 2.54 2.59 NT2RP5003506 4.96 4.96 9.3 7.83 10.37 9.04 NT2RP5003512 2.21 2.21 4.35 2.63 3.46 2.15 NT2RP5003522 4.1 4.1 5.97 4.62 4.19 2.34 NT2RP5003524 4.38 4.38 3.86 1.61 1.54 0.84 ** - NT2RP5003527 24.72 24.72 71.27 76.81 87.24 60.59 NT2RP5003531 7.16 7.16 17.2 15.58 14.06 14.11 NT2RP5003534 2.68 2.68 5.49 5.54 6.82 4.55 NT2RP6000020 8.69 8.69 19.96 14.65 15.13 16.29 NT2RP6000022 3.19 3.19 4.05 4.06 3.96 2.44 NT2RP6000050 3.95 3.95 3.99 4.98 5.82 2.88 NT2RP6000063 3.91 3.91 6.04 3.61 2.52 2.56 NT2RP6000074 5.38 5.38 4.88 3.41 3.27 2.17 ** - NT2RP6000083 7.76 7.76 11.18 11.49 16 9.91 NT2RP6000100 2.49 2.49 4.58 4.04 4.71 3.3 NT2RP6000123 1.94 1.94 3.29 5.1 4.26 4.22 * + NT2RP6000129 1.9 1.9 4.47 4.06 4.27 2.74 NT2RP6000147 3.75 3.75 11.74 10.8 11.03 7.48 NT2RP6000163 2.62 2.62 4.23 2.28 1.95 1.71 NT2RP6000181 8.03 8.03 12.4 9.44 13.25 9.01 NT2RP6000182 5.44 5.44 6.42 4.82 5.56 3.88 OVARC1000001 4.97 4.97 5.24 6.04 7.48 2.35 OVARC1000003 3.21 3.21 8.31 8.51 7.66 7.05 OVARC1000004 9.87 9.87 116.19 88.04 109.99 85.44 OVARC1000006 3.57 3.57 6.58 9.04 7.88 4.73 OVARC1000013 6.51 6.51 9.19 7.32 8.36 8.33 OVARC1000014 3.39 3.39 5.02 4.23 5.02 4.17 OVARC1000017 3.11 3.11 6.81 4.2 4.45 2.72 OVARC1000026 24.79 24.79 32.1 56.82 69.34 44.53 * + OVARC1000035 11.11 11.11 20.26 20.41 23.65 15.36 OVARC1000037 8.73 8.73 19.12 15.64 9.13 15.9 OVARC1000058 6.06 6.06 11.69 13.84 7.56 10.6 OVARC1000060 1.89 1.89 6.28 5.98 5.24 5.13 OVARC1000068 2.38 2.38 5.33 5.31 3.56 2.42 OVARC1000069 74.66 74.66 101.53 75.95 84.36 86.42 OVARC1000071 4.4 4.4 4.77 6.47 5.35 4.04 OVARC1000075 55.43 55.43 125.63 120.89 150.97 117.03 OVARC1000083 9.58 9.58 9.24 13.12 12.7 10.64 * + OVARC1000085 106.6 90.9 156.14 214.2 177.05 273.14 * + OVARC1000086 3.98 6.82 9.23 11.98 11.3 14.09 * + OVARC1000087 1.51 2.83 1.79 4.03 3.57 3.35 * + OVARC1000090 1.48 4.1 6.14 10.88 9.58 8.79 * + OVARC1000091 4.88 8.33 8.01 7.99 7.76 6.82 OVARC1000092 2.83 6.81 4.18 4.68 6.25 4.85 OVARC1000105 9.73 14.86 17.21 26.29 25.62 22.88 * + OVARC1000106 26.02 23.03 46.38 66.36 50.1 53.01 * + OVARC1000109 9.12 13.08 18.04 16.72 12.91 17.46 OVARC1000113 4.12 6.25 6.53 6.83 8.19 7.65 OVARC1000114 2.14 3.44 5.77 5.94 5.86 4.98 OVARC1000133 2.53 4.96 6.36 4.05 4.97 2.95 OVARC1000137 6.14 10.05 13.51 13.3 18.59 14.39 OVARC1000139 14.75 20.77 83.44 71.14 98.1 69.29 OVARC1000145 0.72 6.64 2.89 1.78 2.42 2 OVARC1000148 5.09 4.98 7.88 4.91 5.32 7.91 OVARC1000151 1.41 2.11 2.4 3.58 4.08 3.58 ** + OVARC1000157 10.99 14.16 17.51 21.21 25.06 22.76 * + OVARC1000162 1.22 4.4 2.5 2.93 2.49 2.59 OVARC1000168 1.98 8.46 6.2 8.01 9.61 9.96 OVARC1000169 32.03 45.07 49.48 70.63 69.6 89.08 * + OVARC1000178 0.84 5.08 2.53 3.37 3.18 2.78 OVARC1000182 0.8 3.3 1.42 2.02 1.95 1.78 OVARC1000186 2.51 3.72 3.23 5.95 3.27 4.77 OVARC1000188 1.04 2.67 2.33 2.48 2.87 1.9 OVARC1000191 1.01 3.8 2.63 3.12 2.85 2.54 OVARC1000198 2.09 3.59 4.32 5.62 5.12 5.06 * + OVARC1000208 6.49 10.37 22.5 17.79 24.54 22.02 OVARC1000209 7.99 13.69 22.82 23.42 27.81 29.16 OVARC1000212 2.47 5.63 3.59 4.76 5.03 4.88 OVARC1000216 1.72 4.96 4.36 15.43 11.3 12.54 ** + OVARC1000240 2.98 3.53 8.13 5.39 5.46 4.87 OVARC1000241 1.29 2.47 3.18 2.65 3.17 1.4 OVARC1000249 4.14 5.43 8.17 5.46 5 6.13 OVARC1000254 33.15 39.39 100.99 100.41 131.42 100.89 OVARC1000255 0.85 4.83 2.51 2.98 2.45 1.95 OVARC1000267 2.37 6.41 6.71 6.66 7.16 7.31 OVARC1000275 79.02 93.7 161.08 199.43 240.76 175.96 * + OVARC1000287 226.67 224.66 236.08 433.91 512.76 470.31 ** + OVARC1000288 3.2 4.25 7.38 6.23 5.32 4.47 OVARC1000298 8.96 10.09 19.62 13.37 7.19 9.6 OVARC1000302 1.12 2.14 2.13 2.47 1.85 2 OVARC1000304 1.09 2.68 3.23 5.02 3.41 6 OVARC1000307 2.95 6.19 4.74 7.59 4.7 6.29 OVARC1000309 1.18 7.16 3.22 3.24 2.85 2.4 OVARC1000312 2.83 11.64 6.03 4.17 5.4 2.46 OVARC1000313 10.48 19.25 14.81 9.39 17.54 22.17 OVARC1000321 31.6 24.05 47.79 30.5 31.37 15.43 OVARC1000326 1.52 2.3 3.9 3.84 3.17 2.79 OVARC1000327 1.52 3.28 4.24 3.13 1.49 2.46 OVARC1000331 2.22 4.72 2.41 4.33 4.45 4.58 OVARC1000335 2.3 5.84 4.02 2.72 5.16 4.75 OVARC1000347 1.83 8.18 6.24 7.35 9.24 8.44 OVARC1000348 1.61 10.62 3.73 2.84 4.59 3.05 OVARC1000363 3.7 9.61 6.51 7.31 11.52 6.83 OVARC1000377 1.07 2.09 2.43 2.28 2.51 2.45 OVARC1000382 3.34 3.39 4.33 5.07 2.52 1.03 OVARC1000384 4.2 5.42 8.35 5.32 4.4 6.04 OVARC1000401 0.62 3.63 2.09 3.35 4.08 3.64 OVARC1000406 18.98 23.3 49.12 57.09 74.48 54.63 * + OVARC1000407 1.99 6.28 3.99 4.11 6.42 3.16 OVARC1000408 27.5 38.45 70.39 74.84 111.17 71.25 OVARC1000410 6.83 12.72 10.41 4.78 6.65 5.01 OVARC1000411 0.91 1.5 2.6 3.49 3 2.22 OVARC1000414 1.31 2.22 3.7 4.5 3.78 3.71 OVARC1000420 1.44 2.76 3.29 3.3 2.59 2.1 OVARC1000421 1.42 2.65 3.33 3.96 4.21 4.99 * + OVARC1000427 25.78 27.02 130.06 156.9 215.67 142.19 OVARC1000431 10.51 17.6 19.12 33.66 31.78 25.78 * + OVARC1000437 3.14 6.37 7.31 5.97 7.63 6.36 OVARC1000439 5.81 10.95 13.82 21.81 23.01 21.52 ** + OVARC1000440 2.56 3.74 5.01 7.47 9.31 7.08 * + OVARC1000442 2.34 2.38 6.81 6.66 9.5 8.12 OVARC1000443 2.09 2.2 2.88 3.29 3.41 2.62 OVARC1000461 1.11 2.84 2.2 2.55 1.12 2.14 OVARC1000465 3.27 5.01 3.51 3.94 4.62 3.95 OVARC1000466 1.94 5.47 5.9 6.54 10.13 6.76 OVARC1000467 1.01 5.08 2.41 3.65 2.98 3.78 OVARC1000470 1.13 5.81 3.03 3.18 4.02 3.78 OVARC1000473 1.81 1.95 2.65 2.44 4.16 1.39 OVARC1000479 5.67 5.88 9.88 10.35 14.26 6.88 OVARC1000484 3.99 5.74 6.54 8.66 9.93 6.87 OVARC1000486 3.17 4.71 4.49 5.74 4.93 4.28 OVARC1000496 0.93 3.55 0.66 0.31 1.07 0.62 OVARC1000520 0.84 5.89 1.18 1.32 2.27 2 OVARC1000522 4.1 7.19 12 13.85 14.03 10.34 OVARC1000526 1.96 7.04 3.75 5.93 5.48 4.69 OVARC1000529 2.38 2.57 4.44 3.66 4.16 3.08 OVARC1000533 3.3 4.66 7.95 8.89 12.29 7.83 OVARC1000543 0.84 2.44 2.06 2.57 3.08 2.72 OVARC1000550 0.75 3.68 2.32 2.82 4.04 2.34 OVARC1000553 2.1 5.63 7.02 7.72 7.69 6.95 OVARC1000556 5.77 15.21 11.77 8.95 13.91 8.96 OVARC1000557 0.83 5.12 1.4 1.61 2.29 1.88 OVARC1000561 3.48 7.38 9.26 13 17.66 15.09 * + OVARC1000564 8.89 9.02 10.44 17.84 11.31 16.69 * + OVARC1000573 1.87 3.68 4.86 5.75 5.32 3.83 OVARC1000576 24.12 29.23 124.94 83.09 93.83 98.58 OVARC1000578 2.43 4.6 5.53 8.64 4.46 3.93 OVARC1000581 0.34 3.28 1.15 1.75 1.27 1.23 OVARC1000586 22.54 28.9 41.17 34.58 43.39 40.93 OVARC1000588 0.74 5.23 2.03 2.75 3.72 2.05 OVARC1000605 1.98 2.62 2.88 4.47 4.23 3.87 ** + OVARC1000622 3.86 4.59 11.57 12.7 11.13 11.6 OVARC1000636 1.64 3.79 4.58 4.19 4.03 5.09 OVARC1000640 1.97 4.72 3.93 4.21 3.67 3.09 OVARC1000649 9.69 14.8 53.54 53.32 64.51 52.67 OVARC1000661 1.14 9.33 2.99 5.34 5.24 5.24 OVARC1000677 8.53 10.16 14.87 11.77 10.98 15.47 OVARC1000678 1.21 4.49 2.71 3.28 4.17 3.26 OVARC1000679 2.86 3.25 4.09 5.29 5.16 6.25 * + OVARC1000681 1.47 1.55 3.2 2.41 2.22 1.71 OVARC1000682 10.09 11.33 50.91 33.79 47.49 44.31 OVARC1000689 3.81 7.1 19.94 20.18 22.12 21.83 OVARC1000700 1.8 10.37 3.18 4.98 4.37 5.14 OVARC1000703 1.74 7.18 5.35 6.4 6.64 7.77 OVARC1000722 10.59 11.92 47.93 43.41 60.06 39.34 OVARC1000726 1.44 3.48 4.62 4.88 5.89 3.58 OVARC1000727 1.93 2.09 4.13 3.78 3.79 3.89 OVARC1000730 5.95 5.86 9.01 4.07 4.16 5.62 OVARC1000741 4.85 6.13 8.74 15.19 10.58 13.71 * + OVARC1000746 0.89 3.61 2.43 2.06 2.9 2.84 OVARC1000764 1.76 4.93 4.77 5.35 7.01 5.44 OVARC1000769 1.13 4.3 3.6 3.76 4.42 5.2 OVARC1000771 2.42 6.28 2.3 4.02 4.81 3.71 OVARC1000773 19.09 24.7 31.93 44.69 56.24 46.24 * + OVARC1000775 11.67 8.94 16.44 12.16 8.7 4.26 OVARC1000778 2.37 3.89 5.69 4.59 6.23 4.92 OVARC1000779 0.8 2.02 1.85 2.23 2.45 1.46 OVARC1000781 1.67 5.05 4.16 6.37 3.45 5.07 OVARC1000787 1.64 4.79 4.22 2.97 5.44 3.25 OVARC1000789 7.62 14.23 16.39 24.95 29.69 25.94 ** + OVARC1000800 2.91 10.72 5.72 6.41 10.65 6.2 OVARC1000802 1.55 8.77 2.97 2.99 5.34 2.76 OVARC1000810 3.37 3.54 8.29 6.66 7.99 7.21 OVARC1000811 2.41 2.73 7.5 4.88 3.67 4.95 OVARC1000814 3.44 4.55 9.03 7.92 11.3 9.05 OVARC1000816 7.64 10.41 12.41 10.99 10.58 14.11 OVARC1000817 1.18 3.38 1.27 1.71 2.14 1.55 OVARC1000834 2.46 8.3 3.39 4.84 5.81 4.01 OVARC1000846 2.23 10.02 5.35 7.38 9.66 7.72 OVARC1000850 1.74 8.37 3.38 3.39 2.51 3.1 OVARC1000853 23.21 24.23 43.4 30.67 37.81 18.39 OVARC1000862 2.28 2.66 4.91 3.05 1.61 1.49 OVARC1000873 2.56 2.98 4.14 4.4 3.79 3.85 OVARC1000875 1.47 3.07 1.79 2.35 3.09 1.87 OVARC1000876 3.71 5.67 4.46 5.11 6.06 5.45 OVARC1000883 6.06 9.53 9.18 12.43 15.42 13.05 * + OVARC1000885 2.84 9.95 3.38 3.74 5.66 4.11 OVARC1000886 4.31 8.19 4.29 3.74 5.15 4.39 OVARC1000890 17.47 18.3 91.22 70.97 78.71 51.68 OVARC1000891 1.28 1.44 3.03 2.85 2.19 3.22 OVARC1000897 0.48 1.74 1.29 1.21 1.33 0.5 OVARC1000912 2.06 3.22 4.33 5.21 6.1 5.86 * + OVARC1000914 1.48 6.18 1.61 3.68 3.02 2.18 OVARC1000915 1.71 6.64 4.14 4.87 3.54 4.76 OVARC1000916 1.91 5.19 2.56 4.05 4.32 3.88 OVARC1000924 1.45 5.5 3.09 3.28 3.85 3.48 OVARC1000928 6.05 5.46 8.78 4.22 5.83 5.35 OVARC1000936 1.37 1.39 2.17 2.04 3.25 2.49 OVARC1000937 1.69 3.01 1.94 4.17 3.26 3.24 OVARC1000945 1.55 3.67 3.62 3.83 3.22 2.28 OVARC1000948 1.57 3.85 2.66 3.15 3.68 1.99 OVARC1000956 1.41 5.08 4.36 7.56 7.26 5.51 OVARC1000959 1.8 4.87 3.39 4.88 3.02 3.9 OVARC1000960 2.64 7.53 9.55 11.64 13.89 12.86 * + OVARC1000964 19.89 17.19 103.98 118.41 165.46 96.14 OVARC1000971 0.42 1.58 1.4 2.53 2.27 2.28 * + OVARC1000975 5.93 8.3 36.1 31.27 51.54 30.22 OVARC1000976 0.65 2.12 1.27 2.17 1.46 1.5 OVARC1000981 4.06 7.18 4.94 7.97 12.1 8.53 OVARC1000982 2.83 5.41 2.23 3.13 3.02 3.54 OVARC1000984 1.78 5.43 3.32 3.01 3.08 2.16 OVARC1000995 2.94 6.59 4.5 5.98 6.19 6.72 OVARC1000996 1.68 1.87 4.29 3.58 4.15 4.56 OVARC1000999 6.02 5.65 15.29 15.61 13.18 13.29 OVARC1001000 1.96 4.5 6.2 6.26 7.09 6.86 OVARC1001004 0.51 3.4 1.45 2.05 3.3 1.47 OVARC1001010 1.35 3.99 1.66 3.04 1.4 1.54 OVARC1001011 1.46 5.57 1.13 2.39 3.27 2.45 OVARC1001030 96.19 101.41 143.98 119.24 154.26 133 OVARC1001032 1.42 5.34 1.89 1.83 2.82 1.92 OVARC1001034 4.44 5.58 6.51 3.29 5.21 3.77 OVARC1001038 3.62 5.03 7.4 10.3 10.88 8.61 * + OVARC1001040 2.63 3.77 6.93 5.25 6.51 4.25 OVARC1001041 4.54 8.03 12.87 8.57 12.25 9.4 OVARC1001044 1.05 2.92 1.83 1.96 2.43 1.84 OVARC1001049 3.78 8.78 10.67 10.65 11.87 10.26 OVARC1001051 40.95 55.97 80.66 66.89 109.71 87.49 OVARC1001054 1.22 4.06 3.22 2.86 4.19 1.93 OVARC1001055 2.13 3.38 3.82 4.32 5.61 5.22 * + OVARC1001062 5.8 6.15 12.54 8.04 9.94 9.57 OVARC1001065 8.85 13.63 51.33 51.41 60.3 56.97 OVARC1001068 2.82 5.62 4.76 4.72 4.02 5.52 OVARC1001072 0.73 4.18 4.41 3.2 3.71 3.07 OVARC1001073 0.92 5.7 2.65 2.91 2.54 1.79 OVARC1001074 0.81 4.66 3.31 1.87 2.95 2.04 OVARC1001078 2 5.12 2.79 3.57 3.08 2.83 OVARC1001085 2.41 2.83 3.66 5.54 5.02 6.36 ** + OVARC1001086 1.97 3.17 2.85 3.98 2.83 4.13 OVARC1001091 16.24 19.32 92.73 76.48 96.74 77.99 OVARC1001092 4.62 5.35 7.22 9.69 7.84 6.05 OVARC1001104 1.05 4.37 2.66 3.16 2.58 2.03 OVARC1001107 11.59 15.6 40.28 31.21 49.49 42.22 OVARC1001113 1.04 5.81 1.59 2.46 3.05 2.39 OVARC1001117 2.71 6.63 4.31 4.67 5.74 2.67 OVARC1001118 2.38 3.69 7.08 7.36 6.91 8.28 OVARC1001125 2.02 2.9 3 5.92 4.97 5.9 ** + OVARC1001129 2.61 4.58 3.19 8.46 9.43 11 ** + OVARC1001132 1.7 6.48 2.66 3.69 4.26 4.66 OVARC1001138 9.52 15.82 23.8 48.95 45.16 44.97 ** + OVARC1001141 1.68 4.97 3.48 3.77 3.68 3.84 OVARC1001154 18.31 29.49 68.39 60.43 83.49 65.64 OVARC1001161 2.49 5.55 6.15 7.03 6.69 5.89 OVARC1001162 2.2 3.13 5.34 5.09 4.86 5.26 OVARC1001163 0.69 3.59 2.77 2.2 3.98 2.54 OVARC1001167 3.03 4.57 7.69 10.19 12.95 9.3 * + OVARC1001169 0.74 4.87 2.68 2.47 1.91 2.06 OVARC1001170 7.81 15.04 17.59 14.61 19.45 14.99 OVARC1001171 15.57 17.71 24.31 16.12 23.34 22.51 OVARC1001173 2.09 5.08 5.1 4.32 6.75 5.49 OVARC1001176 22.57 21.48 89.96 76.74 102.3 70.7 OVARC1001180 3.01 4.58 12.7 11.81 10.77 9.56 OVARC1001188 2.66 3.7 3.95 3.62 3.44 4.16 OVARC1001200 1.52 4.56 3.62 3.47 2.9 2.96 OVARC1001202 3.75 6.65 6.53 9.26 7.79 10.23 * + OVARC1001206 1.52 5.52 1.15 1.59 1.13 1.9 OVARC1001209 4.89 8.92 27.46 24.69 30.38 24.27 OVARC1001219 1.81 6.36 4.71 5.33 3.95 3.62 OVARC1001222 2.5 8.36 5.01 3.2 4.34 5.63 OVARC1001232 2.91 4.18 7.74 6.75 6.02 5.65 OVARC1001240 2.05 3.27 6.84 5.55 5.06 5.4 OVARC1001243 0.94 2.59 1.76 3.64 2.64 1.86 OVARC1001244 9.07 12.05 18 21.61 18.57 26.62 OVARC1001246 30.48 50.95 48.51 80.54 100.83 101.88 ** + OVARC1001247 3.64 9.86 7.7 6.57 7.02 4.49 OVARC1001260 1.05 9.07 1.85 2.62 2.65 1.85 OVARC1001261 4.23 10.5 6.99 3.46 2.08 2.94 OVARC1001268 24.4 19.69 52.37 32.58 35.32 14.16 OVARC1001270 14.46 15.1 20.83 9.69 9.8 8.65 * - OVARC1001271 2.62 3.62 3.88 3.95 7.02 4.26 OVARC1001282 0.88 3.02 3.09 1.37 1.59 2 OVARC1001296 3.02 8.06 2.3 3.04 4.11 5.41 OVARC1001306 1.48 8.27 2.4 2.04 2.29 3.82 OVARC1001314 0.49 8.47 1.57 1.06 1.79 1.32 OVARC1001316 2.77 7.17 4.81 5.48 8.11 5.36 OVARC1001329 6.12 6.18 21.11 17.09 19.29 16.22 OVARC1001330 0.2 1.89 1.38 1.22 1.35 1.42 OVARC1001336 1.92 3.7 3.59 5.67 4.09 4.02 OVARC1001338 0.26 2.87 0.86 2.49 1.71 1.07 OVARC1001339 12.07 18.29 22.73 33.65 32.72 37.29 ** + OVARC1001340 0.72 4.83 1.23 1.33 2.44 1.3 OVARC1001341 4.35 9.25 6.77 7.94 11.38 9.69 OVARC1001342 90.37 98.53 136.12 129.68 163.22 127.78 OVARC1001344 2.1 2.51 6.27 6.52 6.89 6.2 OVARC1001357 5.61 8.93 16.02 15.52 11.34 11.69 OVARC1001359 8.96 12.4 16.15 21.66 13.84 10.6 OVARC1001360 0.44 2.52 0.99 1.97 2.6 1.62 OVARC1001369 1.56 5.66 1.89 3.41 1.88 3.1 OVARC1001372 0.96 4.23 3.33 1.52 2.77 1.95 OVARC1001376 1.82 5.1 3.62 5.79 5.79 4.18 OVARC1001381 4.51 6.44 9.94 10.95 12.91 11.21 OVARC1001391 0.5 1.62 1.44 1.88 1.27 1.26 OVARC1001392 2.12 4.69 6.14 11.96 12.7 7.79 * + OVARC1001399 0.98 3.59 2.16 1.77 2.54 1.1 OVARC1001417 1.01 3.07 1.76 2.39 3.61 2.81 OVARC1001419 2.47 5.4 3.06 4.39 4.03 3.16 OVARC1001425 2.29 5.58 5.15 8.76 8.5 8.07 * + OVARC1001436 1.37 5.85 2.54 2.9 3.57 3.18 OVARC1001442 0.64 4.84 1.39 2.27 1.52 0.69 OVARC1001451 3.09 2 3.89 5.18 5.98 4.75 * + OVARC1001452 1.35 2.41 2.87 2.96 4.69 3.13 OVARC1001453 1.21 2.84 1.88 2.3 1.82 1.57 OVARC1001476 10.67 14.38 16.52 17.22 12.9 13.09 OVARC1001480 0.93 4.73 1.5 3.1 2.98 2.21 OVARC1001489 0.97 6.89 2.51 3.01 2.83 2.09 OVARC1001493 2.09 6.59 3.75 7.38 8.78 10.48 * + OVARC1001496 4.65 9.58 8.63 10.74 7.37 11.03 OVARC1001499 1.24 1.18 2.6 3.47 2.68 2.84 OVARC1001506 2.9 2.7 5.31 5.33 6.73 5.48 OVARC1001509 1.73 3.89 3.69 4.07 4.59 3.07 OVARC1001510 0.16 3.69 1.42 1.94 1.73 0.86 OVARC1001516 2.57 5.78 3.85 6.04 4.97 4.39 OVARC1001525 0.53 4.76 2.12 1.94 2.01 1.81 OVARC1001542 8.8 12.86 13.01 15.91 13.63 17.23 OVARC1001544 2.14 6.6 6.72 7.54 8.33 6.22 OVARC1001546 4.08 4.32 4.6 6.12 5.31 7.23 * + OVARC1001547 1.29 2.53 1.68 2.44 1.85 2.22 OVARC1001555 10.39 16.51 68.77 48.66 65.39 56.39 OVARC1001560 3.35 4.91 5.52 5.36 4.93 5.34 OVARC1001569 1.63 4.75 4.79 5.92 5.19 5.1 OVARC1001570 3.96 7.9 6.93 7.72 10.7 8.55 OVARC1001577 1.68 5.89 5.41 8.61 6.9 10.2 OVARC1001578 0.25 3.47 -0.19 -0.47 0.24 0.15 OVARC1001596 12.13 11.65 14.23 13.51 14.82 27.15 OVARC1001600 1.13 2.9 1.48 2.81 2.67 3.67 OVARC1001607 6.22 7.72 10.91 13.42 14.01 13.45 * + OVARC1001610 1.81 5.25 2.84 4.25 2.66 2.7 OVARC1001611 0.13 5.11 1.24 1.48 2.89 1.79 OVARC1001615 0.58 5.42 1.93 1.54 2.56 1.74 OVARC1001636 1.09 3.75 1.05 2.39 2.05 2.15 OVARC1001668 3.77 6.75 10.04 10.5 11.4 10.48 OVARC1001702 1.18 2.21 2.42 3.86 2.07 2.25 OVARC1001703 2.82 3.18 2.97 2.64 4.71 4.65 OVARC1001710 3.58 7.03 8.67 8.01 6.28 9.55 OVARC1001711 1.96 7.3 3.36 5.01 4.15 5.4 OVARC1001713 9.17 11.54 44.65 36.47 51.48 43.79 OVARC1001725 1.01 5.45 6.11 2.56 3.77 4.01 OVARC1001726 1.64 4.48 3.23 4.97 5.6 5.18 OVARC1001727 1.4 2.41 1.52 1.43 2.35 1.14 OVARC1001731 120.62 110.86 255.43 140.73 139.03 74.2 OVARC1001735 1.29 3.44 3.54 3.75 3.25 2.89 OVARC1001741 3.3 4.73 15.28 13.09 12.93 13.17 OVARC1001745 2.72 5.39 6.83 9.17 10.23 8.89 * + OVARC1001759 3.31 9.01 6.31 7.61 7.61 11.95 OVARC1001762 3.96 7.78 6.38 10.3 11.01 13.4 * + OVARC1001766 5.33 7.8 11.99 15.56 16.86 15.33 * + OVARC1001767 0.94 3.76 1.18 1.97 1.96 2.41 OVARC1001768 3.31 3.86 3.76 5.35 4.59 3.54 OVARC1001770 3.04 6.58 9.98 11.46 9.08 9.46 OVARC1001776 2.11 4.7 3.5 4.72 3.64 2.92 OVARC1001791 1.13 4.77 3.54 3.07 3.12 3.42 OVARC1001795 0.89 6.19 1.24 2.31 2.87 2.11 OVARC1001798 2.81 12.11 7.57 9.72 11.93 9.04 OVARC1001802 1.73 11.64 4.9 5.6 5.93 4.01 OVARC1001805 1.92 6.96 2.58 3.62 4.59 3.51 OVARC1001807 1.9 2.53 4.18 3.06 3.12 2.46 OVARC1001809 12.38 14.06 76.32 55.87 81.41 52.83 OVARC1001812 1.44 3.39 3.15 3.23 4.63 3.71 OVARC1001813 1.61 4.29 2.33 2.93 3.98 2.51 OVARC1001820 1.67 7.15 3.21 3.47 3.76 3.22 OVARC1001828 0.78 6.85 2.36 1.91 3.23 2.2 OVARC1001833 1.07 8.12 2.02 2.4 2.1 1.92 OVARC1001839 1.56 8.43 2.98 2.91 3.59 1.15 OVARC1001846 1.91 1.38 2.9 2.15 2.11 1.8 OVARC1001849 1.21 2.52 2.42 5.79 3.69 4.03 * + OVARC1001861 1.46 3.56 2.73 2.78 2.5 2.09 OVARC1001873 3.09 3.78 4.68 5.47 4.42 4.73 OVARC1001879 1.44 6.08 3.48 2.35 2.93 2.22 OVARC1001880 0.91 7.84 2.94 3.63 5.78 3.8 OVARC1001883 0.99 7.61 3.12 2.61 3.42 2.52 OVARC1001900 1.11 7.07 4.03 2.57 3.61 2.89 OVARC1001901 0.54 1.84 1.21 2.42 1.37 2.43 OVARC1001911 0.59 1.57 1.66 1.51 1.39 1.55 OVARC1001916 1.86 3.13 3.35 4.16 4.61 3.51 OVARC1001928 1.45 3.53 1.55 1.58 1.62 1.72 OVARC1001937 5.12 11.69 8.13 17.41 11.63 15.16 OVARC1001940 1.1 4.51 3.13 3.72 3.14 2.78 OVARC1001942 3.85 7.4 8.03 11.47 13.91 12.77 * + OVARC1001943 7.16 10.07 11.08 9.62 13.85 11.87 OVARC1001949 1.69 3.34 4.15 5.35 4.01 5.55 OVARC1001950 1.53 2.41 3.79 6.3 4.35 3.98 OVARC1001952 11.3 11.38 53.57 52.33 78.84 38.05 OVARC1001954 1.12 2.99 2.2 3.09 2.67 2.05 OVARC1001963 1 4.91 2.89 4.5 3.39 3.21 OVARC1001983 3.62 14.16 14.25 20.96 19.21 21.67 OVARC1001987 3.12 6.54 5.94 6.08 8.39 8.02 OVARC1001989 1.41 5.2 4.96 4.54 5.59 5.26 OVARC1001991 1.74 3.27 4.08 4.57 3.86 3.27 OVARC1002005 4.14 3.55 7.66 10.01 9.06 8.2 * + OVARC1002044 3.73 3.94 6.17 6.57 8.32 6.99 * + OVARC1002046 10.28 16.21 20.07 29.4 37.78 37.02 ** + OVARC1002050 1.7 5.6 2.43 3.96 3.82 2.53 OVARC1002058 4.23 6.11 4.02 4.69 5.55 5.43 OVARC1002066 11.47 13.5 25.49 26.02 28.69 22.63 OVARC1002082 3.6 8.55 8.81 9.6 8.89 6.49 OVARC1002091 3.17 5.67 8.37 9.49 5.49 7.64 OVARC1002092 1.38 2.72 2.2 4 3.97 1.88 OVARC1002093 1.79 3.1 4.51 5.01 4.44 3.88 OVARC1002094 1.55 6.24 4.17 36.42 27.25 28.35 ** + OVARC1002107 1.42 4.63 2.69 4.86 5.48 3.6 OVARC1002112 6.17 11.59 8.5 13.47 17.48 11.92 OVARC1002126 2.66 6.35 6.68 7.95 6.44 8.79 OVARC1002127 0.73 5.04 1.86 1.92 2.61 1.52 OVARC1002138 1.4 1.79 1.86 3.16 4.82 2.75 * + OVARC1002143 0.73 1.51 1.55 1.29 3.03 2.09 OVARC1002156 2.42 3.87 4.19 4.43 3.9 3.65 OVARC1002158 0.88 2.63 1.6 2.36 1.57 1.51 OVARC1002165 4.85 6.3 9.83 10.73 14.03 10.87 OVARC1002176 0.86 5.08 3.59 2.01 3.46 2.64 OVARC1002178 0.83 5.35 3.12 3.8 5.02 4.25 OVARC1002182 1.29 2.89 3.77 2.45 4.64 3.12 OVARC1002185 11.45 13.19 62.79 43.91 53.43 55.56 PLACE1000004 1.42 3.23 2.35 3.87 4.25 4.05 * + PLACE1000005 1.18 3.06 3.3 5.27 5.31 4.83 * + PLACE1000006 2.01 8.33 3.23 4.2 5.44 4.67 PLACE1000007 0.97 5.13 2.89 3.03 2.47 2.56 PLACE1000014 2.9 8.06 6.26 6.67 8.18 6.55 PLACE1000031 0.88 4.81 0.45 2.61 2.71 2.79 PLACE1000033 1.23 2.15 2.75 2.42 3.17 2.56 PLACE1000040 3.08 4.43 6.18 7.11 5.54 7.37 PLACE1000048 1.83 3.24 2.14 3.32 3.96 3.74 PLACE1000050 2.12 5.36 9.1 9 6.55 8.25 PLACE1000061 138.29 147.36 249.77 165.55 233.98 230.37 PLACE1000066 14.23 15 19.46 15.86 15.62 18.52 PLACE1000075 3.03 6.24 9.08 4.98 6.93 7.11 PLACE1000078 2.1 5.75 5 6.07 6.93 5.19 PLACE1000081 1.08 1.88 1.52 1.13 1.89 1.27 PLACE1000086 4.97 6.55 11.25 8.1 9.16 7.75 PLACE1000094 0.7 4.18 1.72 1 3.44 2.96 PLACE1000101 4.67 8.44 7.7 11.69 10.38 13.65 * + PLACE1000121 0.87 6.29 2.02 1.95 2.85 2.39 PLACE1000133 6.65 11.93 17.66 15.19 17.59 21.71 PLACE1000142 1.79 6.03 5.66 2.64 4.77 4.24 PLACE1000146 1.95 4.51 2.89 3.71 5.02 2.82 PLACE1000163 4.52 5.99 10.71 16.27 10.95 13.78 PLACE1000172 1.12 2.63 1.48 1.81 3.21 2.29 PLACE1000181 1.06 3 2.98 2.63 3.75 2.86 PLACE1000184 1.17 3.08 1.48 1.87 3.28 2.27 PLACE1000185 2.99 6.52 8.47 9.53 9.99 12.03 PLACE1000198 0.78 4.09 2.49 2.19 2.17 1.93 PLACE1000213 3.3 5.87 7.36 4.35 5.38 8.09 PLACE1000214 1.37 4.29 4.54 5.22 6.72 4.22 PLACE1000220 9.61 7.84 16.78 7.48 5.77 4.1 PLACE1000231 2.48 4.1 4.92 4.57 4.65 3.91 PLACE1000236 0.66 3.33 2.43 2.8 3.63 2.37 PLACE1000245 2.92 5.88 6.34 9.34 11.24 10.55 * + PLACE1000246 5.15 8.27 9.95 3.29 2.55 2.86 * - PLACE1000258 5.4 12.61 13.52 14.88 16.7 14.95 PLACE1000288 1.68 7.22 2.96 2.83 4.02 2.48 PLACE1000292 3.72 9.02 8.85 10.23 20.58 9.21 PLACE1000302 0.56 1.01 1.39 1.07 0.92 0.62 PLACE1000304 1.13 3.26 3.17 3.75 2.32 3.05 PLACE1000308 2.54 4.35 4.17 4.42 3.87 1.34 PLACE1000309 2.29 4.02 4 6.72 5.23 7.88 * + PLACE1000312 1.33 3.44 2.48 2.74 3.99 2.5 PLACE1000330 0.46 5.76 3.02 1.32 1.93 1.35 PLACE1000332 1.02 8.82 2.01 3.01 3.78 1.68 PLACE1000347 2.3 9.48 3.89 2.59 5.81 3.22 PLACE1000351 1.2 1.5 2.87 2.2 2.4 2 PLACE1000374 2.01 3.03 7.02 8.89 6.55 6.85 PLACE1000380 2.39 4.27 3.95 4.9 2.12 2.38 PLACE1000383 1.03 2.62 1.9 2.53 3.64 2.4 PLACE1000397 0.63 4.06 1.89 2.82 3.34 3.47 PLACE1000401 1.22 6.39 2.24 2.23 3.05 2.36 PLACE1000406 1.08 8.76 3.4 3.72 4.08 3.64 PLACE1000412 1.61 6.38 1.56 1.62 3.45 1.46 PLACE1000420 2.59 3.51 4.6 8.95 7.28 5.6 * + PLACE1000421 0.99 1.3 2.32 2.97 2 1.7 PLACE1000423 16.6 23.29 32.85 10.67 8.02 8.09 * - PLACE1000424 1.36 3.09 2.12 3.35 2.65 1.97 PLACE1000430 0.77 4.36 1.95 3.51 2.94 3.77 PLACE1000433 1.06 5.9 1.65 1.89 2.6 1.8 PLACE1000435 1.39 7.21 4.77 6.22 6.29 4.22 PLACE1000437 6.06 10.65 10.14 17.29 20.07 18.79 ** + PLACE1000442 3.75 3.85 6.27 7.81 5.7 6.7 PLACE1000444 2.14 3.94 8.96 11.14 11.55 9.8 PLACE1000453 5.57 11.03 14.16 10.42 7.4 2.99 PLACE1000456 1.25 2.21 1.97 1.33 2.18 1.07 PLACE1000465 2.09 5.63 6.62 12.97 11.8 10.69 ** + PLACE1000481 2.32 8.1 3.73 6.89 6.64 6.45 PLACE1000492 1.15 4.45 2.95 3.27 3.06 2.81 PLACE1000508 1.36 4.64 4 3.91 4.24 3.71 PLACE1000512 4.91 4.29 6.39 8.12 7.8 4.6 PLACE1000540 5.18 3.93 7.84 5.44 6.9 5.57 PLACE1000541 13.59 15.07 48.84 60.62 81.24 41.96 PLACE1000546 0.86 3.61 2.82 4.72 4.63 2.5 PLACE1000547 2.16 4.61 3.83 6.31 5.64 5.92 * + PLACE1000560 2.08 5.97 2.1 1.62 2.8 1.72 PLACE1000562 2.8 6.23 6.04 8.86 11.26 8.61 * + PLACE1000564 1.54 6.4 3.07 3.16 4.41 3.43 PLACE1000583 3.75 3.28 6.32 6.78 11.53 6.8 PLACE1000587 8.52 9.32 12.99 13.64 14.69 9.43 PLACE1000588 1.92 4.36 3.99 8.79 8.15 4.48 PLACE1000596 1.99 5.34 4.39 7.8 6.74 4.51 PLACE1000599 2.39 5.51 7.05 7.92 7.79 6.46 PLACE1000605 5.12 11.43 7.06 14.2 15.1 12.67 * + PLACE1000610 2.01 6.08 3.54 5.26 4.48 2.94 PLACE1000611 13.18 19.13 24.68 16.45 20.37 22.79 PLACE1000626 3.19 4.04 8.04 5.71 9.93 8.12 PLACE1000633 1.32 2.12 3.95 4.8 6.06 3.59 PLACE1000636 1.15 2.54 1.43 2.72 4.25 2.94 PLACE1000653 5.07 8.56 9.29 11.07 11.87 14.08 * + PLACE1000656 4.2 12.9 25.22 16.66 16.71 12.92 PLACE1000663 2 6.43 3.59 2.39 6.61 4.03 PLACE1000706 2 6.3 5.04 5.37 7.27 6.26 PLACE1000712 3.9 9.52 10.82 10.49 10.07 9.11 PLACE1000716 0.98 2.75 3.44 2.44 3.2 2.82 PLACE1000740 2.74 5.28 6.24 8.83 8.13 9.69 * + PLACE1000748 3.35 3.51 6.81 3.12 5.02 4.23 PLACE1000749 3.49 6.35 5.94 4.61 4.65 6.02 PLACE1000751 2.71 5.34 4.07 7.81 8.32 8.36 ** + PLACE1000755 1.39 6.14 1.93 2.55 5.1 2.96 PLACE1000769 2.29 6.8 3.45 3.33 4.58 2.6 PLACE1000778 0.87 1.48 1.99 2.05 2.94 2.38 PLACE1000785 9.56 12.21 27.18 28 24.34 29.54 PLACE1000786 2.68 4.22 3.63 3.09 3.77 3.7 PLACE1000793 4.05 7.21 6.7 6.06 7.6 9.1 PLACE1000795 2.15 5.5 3.99 4.44 5.29 4.31 PLACE1000798 0.88 8.44 3.24 3.13 3.8 3.72 PLACE1000812 2.13 5.08 4.46 5.06 5.16 6.03 PLACE1000823 1.71 5.2 4.89 5.67 7.28 4.84 PLACE1000825 1.6 2.86 2.02 3.77 3.96 3.76 * + PLACE1000838 16 15.77 23.73 13.88 15.6 15.65 PLACE1000841 1.22 3.78 3.31 3.97 10.65 3.77 PLACE1000843 2.14 6.2 5.68 5.79 7.7 5.38 PLACE1000849 2.79 8.82 6.72 7.24 6.78 10.02 PLACE1000856 2.01 5.3 3.59 3.42 4.79 4.19 PLACE1000863 5.2 7.58 9.56 8.97 12.34 11.53 PLACE1000876 3.65 7.6 6.02 6.7 9.95 9.06 PLACE1000899 1.36 2.24 3.12 4.12 5.14 4.22 * + PLACE1000907 4.82 5.53 9.59 6.77 8.44 5.83 PLACE1000909 1.18 3.31 2.45 3.65 3.88 3.44 PLACE1000912 0.42 4.55 1.77 1.76 2.72 1.46 PLACE1000914 1.05 4.41 3.5 3 6.09 4.22 PLACE1000918 0.54 4.49 1.61 1.82 3.13 1.98 PLACE1000927 10.48 12.41 16.9 20.91 23.21 25.47 * + PLACE1000931 0.69 3.44 2.12 2.44 3.94 3.3 PLACE1000944 2.55 2.24 4.78 3.84 3.32 2.09 PLACE1000948 0.52 2.31 2.96 2.21 2.72 1.72 PLACE1000958 0.12 2.2 1.73 1.11 1.77 2.27 PLACE1000972 1.01 3.43 2.89 4.49 5.33 3.75 PLACE1000977 2.33 5.67 4.42 2.71 5.33 5.25 PLACE1000979 1.63 8.01 3.93 4.24 5.92 4.57 PLACE1000986 3.37 16.51 6.63 6.97 8.75 7.69 PLACE1000987 1.76 10.13 4.79 4.17 4.74 5.11 PLACE1001000 4.85 4.62 7.76 6.02 4.25 3.02 PLACE1001007 7 6.94 14.66 5.39 3.76 3.47 PLACE1001010 0.61 2.04 2.45 2.56 2.73 2.84 PLACE1001015 0.88 2.55 1.84 2.36 1.72 2.42 PLACE1001016 1.79 4.54 4.29 6.37 9 6.57 * + PLACE1001022 0.68 6.5 2.45 1.9 2.39 1.29 PLACE1001024 1.05 8.89 1.83 1.34 2.49 2.35 PLACE1001036 2.63 10.55 5.42 3.62 5.49 5.43 PLACE1001038 50.16 49.81 118.83 82.67 64.83 52.8 PLACE1001048 1.07 1.82 0.92 2.39 2.09 1.21 PLACE1001054 9.95 10.74 63.88 62.96 79.44 66.71 PLACE1001062 1.45 4.19 3.71 3.12 4.17 3.05 PLACE1001063 1.35 3.74 2.2 4.06 3.65 2.74 PLACE1001076 0.46 6.48 1 1.86 2.18 1.62 PLACE1001081 1.53 7.95 3.33 3.65 5.24 4.8 PLACE1001088 1.32 5.24 1.22 1.42 2.81 1.37 PLACE1001092 2.31 2.47 4.68 5.8 4.18 3.9 PLACE1001098 0.93 2.62 4.53 5.49 4.05 3.17 PLACE1001100 1.31 2.58 2.48 4.27 4.17 3.37 * + PLACE1001104 1.95 4.09 4.54 3.39 3.42 4.47 PLACE1001114 1.56 6.54 4.33 5.17 3.78 3.27 PLACE1001118 2.52 5.77 6.12 6.21 6.14 5.1 PLACE1001123 2.86 5.3 7.53 7.08 8.51 7.63 PLACE1001136 1.58 4.39 5.13 5.29 5.95 5.85 PLACE1001144 6.27 5.67 13.43 10.34 11 10.08 PLACE1001147 2.11 2.98 6.03 6.13 5.15 4.83 PLACE1001148 1.72 1.31 1.89 1.76 2.39 2.31 PLACE1001159 0.86 2.37 2.05 2.27 3.73 1.43 PLACE1001168 8.87 14.52 15.09 25.46 23.18 30.79 * + PLACE1001171 0.69 3.89 1.23 2.53 1.42 1.53 PLACE1001183 0.24 3.61 1.81 1.57 2.78 1.38 PLACE1001185 3.13 7.43 3.76 5 6.4 5.64 PLACE1001201 1.77 2.8 3.29 6.32 6.94 6.32 ** + PLACE1001229 7.51 8.56 12.64 15.24 11.45 10.42 PLACE1001231 1.83 2.73 3.07 4.09 5.1 2.3 PLACE1001238 1.52 4.35 3.74 3.65 4.52 4.57 PLACE1001241 1.63 5.58 2.92 5.73 8.13 7.04 PLACE1001242 22.28 29.54 30.28 46.43 48.89 62.65 * + PLACE1001247 2.43 7.02 4.07 5.03 5.91 4.52 PLACE1001250 1.01 5.36 3.61 4.68 4.39 4.81 PLACE1001257 2.99 3.06 7.06 7.89 9.21 7.69 PLACE1001272 3.19 4.27 5.68 7.13 6.43 5.14 PLACE1001279 0.96 3.12 2.74 3.08 3.81 3.29 PLACE1001280 1.08 4.75 2.68 4.98 4.45 2.86 PLACE1001294 1.91 7.23 6.91 4.88 5.57 6.18 PLACE1001295 4.16 9.94 7.53 8.55 11.85 8.43 PLACE1001300 2.46 7.9 4.31 4.65 14.73 4.95 PLACE1001304 3 8.27 10.47 8.57 10.81 10.64 PLACE1001311 3.95 3.34 5.67 6.85 9.14 7.6 * + PLACE1001323 2.17 2.95 5.12 5.66 8.43 5.5 PLACE1001325 0.88 1.95 3.71 2.84 3.56 3.27 PLACE1001340 5.18 6.99 9.8 8.69 12.02 10.48 PLACE1001344 1.52 3.49 1.77 2.34 2.06 1.75 PLACE1001351 3.23 6.39 8.39 6.4 8.62 6.1 PLACE1001366 1 4.49 4.02 4.19 4.6 3.72 PLACE1001377 3.02 4.97 5.1 7.91 7.28 5.83 * + PLACE1001383 2.31 4.13 3.53 2.62 5.5 5.72 PLACE1001384 1.81 3.23 2.89 2.05 3.43 3.15 PLACE1001387 1.65 3.64 3.7 3.03 4.83 3 PLACE1001395 3.72 6.64 6.54 7.01 7.61 7.73 PLACE1001399 3.71 6.58 9.31 7.37 8.61 9.22 PLACE1001401 0.83 5.25 2.33 1.55 1.76 0.87 PLACE1001407 11.65 21.8 24.47 22.63 18.09 26.24 PLACE1001412 1.6 4.98 4.53 4.08 4.42 3.83 PLACE1001414 2.3 3.02 5.86 7.57 5.13 6.83 PLACE1001416 2.99 4.71 3.29 5.62 4.04 7.08 PLACE1001433 33.62 33.05 51.64 49.1 58.33 55.88 PLACE1001440 1.95 3.99 3.96 3.6 3.53 2.1 PLACE1001456 1.64 5.5 4.26 4.15 4.87 4.49 PLACE1001464 32.76 28.05 47.41 53.22 68.42 61.32 * + PLACE1001468 0.85 5.04 1.17 1.56 2.55 2.27 PLACE1001484 1.31 4.85 2.96 4.25 5.8 3.04 PLACE1001500 0.92 2.22 2.14 2.72 3.34 3.26 * + PLACE1001502 1.36 3.6 3.9 3.54 5.9 4.54 PLACE1001503 1.7 4.58 6.72 7.47 8.2 8.05 PLACE1001505 6.34 14.13 16.16 39.97 27.14 46.65 * + PLACE1001513 4.09 10.82 8.17 5.87 8.53 14.61 PLACE1001516 0.61 4.33 1.33 1.71 3.49 1.99 PLACE1001517 5.56 8.58 14.77 14.14 14.96 14.28 PLACE1001523 12.83 14.09 20.42 22.79 19.74 32.9 PLACE1001526 5.12 4.89 8.42 9.51 9.11 6.89 PLACE1001534 2.12 5.12 3.58 3.62 5.55 3.99 PLACE1001536 0.61 2.5 1.52 2.11 3.2 1.9 PLACE1001545 17.97 23.9 38.46 33.78 45.13 66.08 PLACE1001551 2.55 6.26 6.15 4.72 6.59 6.71 PLACE1001564 1.37 4.87 2.88 4.01 3.57 3.7 PLACE1001570 2.62 5.95 4.18 2.19 3.82 4.32 PLACE1001571 2.04 4.51 6.07 5.69 6.27 5.81 PLACE1001595 4.73 4.64 10.04 11.6 8.27 5.28 PLACE1001602 7.23 8.39 18.65 20.38 18.68 19.71 PLACE1001603 2.01 3.83 5.37 6.86 5.86 4.56 PLACE1001608 3.44 7.22 5.9 5.82 7.73 8.7 PLACE1001610 3.77 8.4 8.22 9.26 9.49 9.85 PLACE1001611 1.94 7.34 3.65 2.28 3.85 1.88 PLACE1001629 0.78 6.77 2.24 3.62 3.36 3.52 PLACE1001632 1.66 8.26 4.04 4.3 4.14 4.37 PLACE1001634 7.4 9.92 39.12 23.85 32.41 18.38 PLACE1001637 0.84 2.16 1.25 1.41 2.4 1.1 PLACE1001640 1.33 3.27 4.66 2.68 4.85 4.49 PLACE1001655 0.83 2.93 2.06 2.82 2.14 2.02 PLACE1001672 1.84 7.04 4.01 3.3 4.41 4.09 PLACE1001676 1.38 8.49 3.54 4.63 4.77 3.85 PLACE1001683 12.79 23.62 24.61 25.33 30.22 27.13 PLACE1001691 3.41 12.29 6.72 9.03 8.96 9.83 PLACE1001692 1.47 2.96 5.25 5.87 5.6 5.13 PLACE1001705 3.02 3.75 9.88 10.06 9.21 8.32 PLACE1001716 1.68 3 2.61 2.24 3.79 3.58 PLACE1001720 1.49 2.62 2.21 1.56 2.45 1.71 PLACE1001728 1.43 6.19 4.24 1.96 2.04 2.51 PLACE1001729 2.12 8.13 4.44 3.8 4.52 4.36 PLACE1001739 2.61 9.55 4.04 4.95 7.24 6.16 PLACE1001740 0.92 5.36 2.09 1.92 2.1 1.69 PLACE1001745 1.15 0.98 3.22 1.87 2.48 2.31 PLACE1001746 1.04 2.25 2.55 4.64 3.4 2.82 PLACE1001748 4.74 7.01 8.18 8.19 6.58 5.96 PLACE1001753 2.06 3.54 3.29 7.44 5.57 5.82 * + PLACE1001756 5.6 11.31 38.07 31.78 44.99 35.99 PLACE1001760 6.54 12.23 12.85 16.36 16.96 16.66 * + PLACE1001767 11.26 14.98 59.72 45.37 61.46 45.39 PLACE1001771 1.96 6.64 4.03 4.32 5.22 4.54 PLACE1001775 2.23 2.81 6.72 5.1 3.11 4.79 PLACE1001777 83.34 145.9 190.82 142.92 71.27 59.69 PLACE1001781 1.9 3.86 4.91 8.72 3.39 2.3 PLACE1001783 0.76 3.21 2.06 4.84 2.09 1.54 PLACE1001786 1.77 6.61 2.72 3.7 3.32 2.6 PLACE1001788 5.16 9.07 7.14 10.52 8.74 9.32 PLACE1001795 1.92 4.4 4.82 5.42 4.61 5.42 PLACE1001799 0.69 3.62 2.11 1.86 2.83 1.97 PLACE1001810 0.89 1.52 1.76 2.73 3.91 1.73 PLACE1001817 5.53 6.12 10.88 10.56 9.4 6.38 PLACE1001821 4.68 6.07 7.11 8.37 9.92 4.99 PLACE1001836 0.91 3.12 2.38 2.69 4.12 2.63 PLACE1001844 1.55 5.1 3.48 4.42 4.36 4.09 PLACE1001845 3.62 8.38 7.39 7.88 7.55 9.93 PLACE1001858 2.56 6.58 3.52 5.26 7.48 6.05 PLACE1001869 3.13 7.15 4.85 6.09 6.46 5.66 PLACE1001890 11.74 11.92 21.45 173.44 255.31 125.13 * + PLACE1001897 9.19 13.85 16.44 22.22 23.13 12.95 PLACE1001902 10.13 12.6 21.53 22.74 27.67 12.77 PLACE1001904 1.38 3.72 1.51 2.45 2.53 2.35 PLACE1001907 3.36 6.76 5.71 7.67 5.67 5.59 PLACE1001910 83.6 82.16 135.34 301.29 325.42 244.59 ** + PLACE1001912 1.53 6.6 3.36 5.54 5.48 4.85 PLACE1001918 17.31 22.95 30.16 31.14 40.44 40.02 * + PLACE1001920 2.07 3.51 5.43 11.97 13.8 11.4 ** + PLACE1001928 3.06 2.96 4.67 5.29 9.7 5.31 PLACE1001930 1.17 3.92 2.2 2.9 4.73 3.22 PLACE1001949 1.16 3.67 1.78 3.84 4.24 3.18 PLACE1001959 1.36 4.7 3.16 2.63 3.17 2.26 PLACE1001969 2.09 7.83 7.21 6.56 10.73 6.57 PLACE1001974 7.39 11.98 11.87 11.43 16.09 16.06 PLACE1001981 0.77 4.38 3.22 1.77 3.88 2.36 PLACE1001983 3.81 4.12 5.32 5.92 6.16 5.72 * + PLACE1001989 2.34 4.15 5.02 4.37 5.91 3.72 PLACE1002004 3.07 4.06 8.05 9.22 9.69 7.18 PLACE1002008 8.4 11.76 17 23.36 22.19 22.42 * + PLACE1002015 26.96 30.92 67.62 105.75 88.42 94.15 * + PLACE1002044 3.79 8.07 5.86 4.64 6.39 6.4 PLACE1002046 1.78 5.68 1.9 4.3 5.79 4.97 PLACE1002052 1.09 4.98 2.26 1.38 2.41 2.32 PLACE1002066 4.79 6.3 8.29 10.24 10.77 9.93 * + PLACE1002072 2.55 3.91 4.86 6 5.48 6 * + PLACE1002073 0.51 2.83 2.29 2.35 4.06 2.91 PLACE1002080 1.81 6.49 6.13 4.76 6.82 5.72 PLACE1002081 1.66 6.13 4.06 3.74 4.86 4.3 PLACE1002090 7.74 16.55 13.87 12.53 14.4 19.41 PLACE1002095 2.97 6.22 8.45 10.01 10.18 11.32 * + PLACE1002102 4.26 8.56 8.81 9.47 9.56 10.67 PLACE1002109 2.57 5.08 3.81 4.66 6.17 6.32 PLACE1002115 1.75 3.57 2.48 2.78 4.26 2.59 PLACE1002119 15.65 15.3 35.78 37.28 32.59 38.23 PLACE1002140 5.25 8.45 14.05 19.93 17.14 17.19 * + PLACE1002150 1.54 8.26 4.25 3.23 5.36 4.12 PLACE1002153 1.6 5.75 2.58 3.47 5.76 4.48 PLACE1002157 0.87 2.96 1.72 1.76 3.28 3.73 PLACE1002163 2.13 4.67 4.55 6.21 8.81 6.03 PLACE1002168 2.39 4.04 4.42 4.68 6.28 3.22 PLACE1002170 2.73 3.53 7.35 4.89 5.33 3.74 PLACE1002171 3.09 6.11 10.02 18.44 14.63 13.93 * + PLACE1002180 3.16 6.23 6.77 4.63 8.54 8.39 PLACE1002184 9.2 15.58 18.42 124.63 250.27 333.14 * + PLACE1002200 1.35 5.67 2.38 2.97 2.89 2.26 PLACE1002205 3.3 6.47 18.07 17.08 18.38 14.61 PLACE1002213 2.2 4.16 4.93 5.52 8.03 6.03 PLACE1002219 1.05 1.91 2.23 3.33 3.53 1.96 PLACE1002227 0.68 2.65 1.7 1.5 3.03 1.67 PLACE1002253 0.32 2.67 1.28 1.47 0.76 0.43 PLACE1002256 1.16 4.78 3.31 3.54 3.01 4.79 PLACE1002259 1.46 5.69 4.48 3.22 2.98 2.31 PLACE1002285 1.16 10.74 2.29 1.55 2.38 1.24 PLACE1002301 9.42 17.5 14.68 12.7 10.48 11.7 PLACE1002310 4.28 10.16 9.86 8.82 7.87 9.94 PLACE1002311 1.84 2.94 3.87 2.96 2.87 2.03 PLACE1002319 2.31 2.64 2.94 3.21 3.23 3.92 * + PLACE1002329 0.56 2.54 2.5 4.07 3.58 3.07 PLACE1002333 1.34 3.1 1.96 1.22 2.44 2 PLACE1002342 4.19 9.04 9.44 5.06 8.52 8.17 PLACE1002343 0.49 6.98 2.94 2.08 1.9 2.52 PLACE1002355 1.31 9.39 2.36 3.33 4.35 2.63 PLACE1002358 1.15 7.94 3.3 2.6 2.65 2.13 PLACE1002359 1.91 2.17 3.47 4.7 3.91 3.42 PLACE1002374 29.69 28.18 54.19 53.9 34.73 36.14 PLACE1002376 3.58 5.91 7.86 6.23 6.82 6.56 PLACE1002379 6.24 7.66 6.63 10.13 9.68 10.9 ** + PLACE1002386 0.86 5.32 1.35 1.87 2.05 1.51 PLACE1002395 3.69 9.97 17.13 16.43 20.62 16.16 PLACE1002399 2.38 11.09 3.42 5.31 10.38 7.39 PLACE1002407 1.09 5.22 2.31 2.3 4.01 3.66 PLACE1002433 1.63 2.17 2.97 2.96 4.35 3.66 PLACE1002437 0.79 1.4 1.47 1.41 3.28 1.35 PLACE1002438 0.74 2.38 1.96 1.8 2.43 3.38 PLACE1002446 4.64 8.42 5.95 10.27 8.88 11.99 * + PLACE1002447 1.26 6.06 2.05 3.92 3.14 4.32 PLACE1002450 1.19 5.92 3.24 4.32 4.21 5.05 PLACE1002462 0.81 4.02 2.94 3.51 2.99 3.13 PLACE1002465 0.96 4.69 2.2 2.69 4.31 2.24 PLACE1002474 1.61 2.26 3.23 3.85 4.41 3.6 * + PLACE1002477 11.11 14.51 32.39 44.06 41.42 26.68 PLACE1002493 3.39 4.1 10.1 14.39 16.66 9.49 PLACE1002497 0.68 2.81 0.67 1.45 0.93 0.99 PLACE1002499 2.12 4.73 3 5.98 6.44 5.28 * + PLACE1002500 2.61 6.52 7.36 7.58 10.45 7.25 PLACE1002514 0.3 4.49 1.84 1.74 2.47 1.75 PLACE1002518 2.86 7.65 6.9 5.62 7.55 4.67 PLACE1002529 1.14 1.56 2.21 3.19 3.4 1.44 PLACE1002532 1.31 1.82 3.18 5.75 4.94 5.59 ** + PLACE1002536 3.59 3.75 3.44 5.84 6.07 3.85 PLACE1002537 1.63 4.06 2.7 2.69 4.07 3.08 PLACE1002539 1.86 5.68 2.75 4.53 5.29 4.78 PLACE1002547 6.09 8.06 7.3 12.32 11.02 11.26 ** + PLACE1002571 2.84 6.85 5.19 6.84 8.65 6.23 PLACE1002578 3.57 8.34 8.35 11.11 12.19 8.11 PLACE1002583 1.33 1.61 2.32 3.18 4.02 2.46 PLACE1002591 0.82 1.62 2.34 3.25 4.43 1.92 PLACE1002598 6.56 10.95 12.39 11.93 9.04 7.74 PLACE1002604 1.73 3.57 2.69 3.75 5.38 3.51 PLACE1002612 2.89 8.47 5.95 11.25 10.88 8.06 PLACE1002625 1.25 4.79 3.18 2.7 3.25 1.82 PLACE1002638 2.94 8.01 6.66 7.78 6.81 7.29 PLACE1002655 1.39 6.51 5.57 7.19 7.62 6.46 PLACE1002665 4.57 3.88 5.4 7.47 12.16 10.75 * + PLACE1002685 0.58 1.12 1.3 0.67 2.43 0.98 PLACE1002692 7.42 8.56 16.7 19.27 22.67 16.29 PLACE1002714 1.8 3 2.11 2.43 3.14 2.24 PLACE1002721 2.94 4.37 3.88 5.88 7.1 4.28 PLACE1002722 0.92 5.42 1.97 1.37 3.28 1.85 PLACE1002726 1.6 6.24 3.66 4.6 5.7 5.26 PLACE1002756 1.57 4.5 7.04 5.92 9.63 7.78 PLACE1002768 1.05 3.72 2.16 2.1 2.34 1.71 PLACE1002772 0.54 2.15 1.32 2.49 2.86 2.3 PLACE1002775 4.33 4.71 9.15 7.05 7.08 8.67 PLACE1002780 185.63 218.72 325.36 272.21 244.38 305.38 PLACE1002782 0.4 3.76 1.1 1.62 1.69 1.14 PLACE1002794 1.5 6.71 3.27 2.26 4.59 4.36 PLACE1002795 1.92 6.45 0.81 2.37 3.63 2.77 PLACE1002811 0.6 1.57 1.34 1.9 1.46 1.16 PLACE1002815 6.39 7 10.49 7.24 3.16 9.21 PLACE1002816 8.5 9.72 9.05 7.22 8.2 7.97 * - PLACE1002822 0.58 2.51 2.06 2.2 2.87 1.94 PLACE1002833 9.98 15.11 16.78 15.42 15.99 16.56 PLACE1002834 3.2 8.08 6.57 6.23 6.79 8.41 PLACE1002835 0.62 4.14 1.72 0.85 1.83 1.79 PLACE1002839 1.13 5.75 2.72 2.89 4.72 2.81 PLACE1002851 1.52 1.87 1.41 1.98 2.15 2.7 PLACE1002853 4.18 6.23 9.15 6.26 5.6 7 PLACE1002881 3.42 5.2 11.04 8.35 11.57 10.26 PLACE1002901 9.66 12.66 20.09 24.14 25.51 30.67 * + PLACE1002904 0.89 7.35 1.41 1.98 1.95 3.09 PLACE1002905 1.36 5.46 3.26 4.04 4.46 3.4 PLACE1002908 1.6 5.19 3.18 3.84 5.27 3.81 PLACE1002911 3.91 6.96 6.9 4.66 7.89 6.75 PLACE1002941 1.57 2.2 2.48 3.94 2.02 2.31 PLACE1002950 9.59 9.15 14.74 5.31 8.02 14.51 PLACE1002955 47.83 40.69 72.7 82.17 62.5 84.64 PLACE1002958 19.36 26.92 35.27 35.6 35.35 59.02 PLACE1002962 1.03 4.03 2.2 1.41 2.63 1.67 PLACE1002967 1.34 4.83 3.19 4.37 3.52 2.81 PLACE1002968 1.2 5.14 2.7 2.55 3.05 1.81 PLACE1002976 8.94 12.08 24.23 24.5 36.89 30.05 PLACE1002991 2.68 3.05 6.66 3.49 4.56 3.6 PLACE1002993 2.72 3.86 5.52 8.21 6.92 5.56 PLACE1002996 2.02 3.03 3.43 5.54 3.52 3.01 PLACE1003010 1.91 3.69 4.27 4.31 3.86 3.32 PLACE1003025 2.85 7.01 6.1 8.57 11.37 10.11 * + PLACE1003027 5.02 13.08 9.31 8.55 12.45 12.76 PLACE1003044 1.95 8.24 2.61 3.64 4.16 2.74 PLACE1003045 1.41 7.75 1.77 1.88 2.64 1.01 PLACE1003052 2.19 3.16 5.74 4.44 3.6 1.99 PLACE1003083 1.59 3.04 3.23 3.06 1.61 2.25 PLACE1003085 3.91 6.19 5.6 9.46 5.89 3.33 PLACE1003092 3.94 4.87 6.25 7 5.6 6.17 PLACE1003097 0.37 3.06 1.44 2.12 1.88 1.63 PLACE1003100 1.65 7.1 4.2 3.88 4.74 4.29 PLACE1003108 1.26 10.37 2.91 3.32 4.44 2.39 PLACE1003115 11.39 18.3 58.59 73.64 99.24 69.1 * + PLACE1003120 3.1 3.08 9.71 11.34 8.32 10.19 PLACE1003135 0.72 2.04 1.09 1.56 2.89 1.08 PLACE1003136 3.95 5.82 6.05 9.03 6.55 7.34 PLACE1003141 2.04 2.97 2.1 1.97 2.49 1.8 PLACE1003145 1.21 4.17 2.52 6.24 6.88 7.67 * + PLACE1003147 2.87 7.85 5.71 5.02 5.25 6.28 PLACE1003153 0.54 7.63 2.14 1.66 3.2 1.82 PLACE1003163 6.09 13.55 8.19 8.39 14.09 12.26 PLACE1003172 23.21 21.74 44.19 47.78 43.17 39.52 PLACE1003174 2.31 2.49 3.75 4.3 3.55 1.68 PLACE1003176 0.47 2 1.89 2.88 1.27 1.46 PLACE1003181 1.72 4.19 2.72 2.5 2.76 2.36 PLACE1003184 0.76 3.92 1.53 1.91 1.49 2.06 PLACE1003190 2.39 9.81 8.67 10.73 7.98 10.34 PLACE1003200 0.29 4.48 1.84 0.72 1.92 1.16 PLACE1003205 3.94 7.07 9.68 6.82 10.38 7.2 PLACE1003209 1.43 2.18 2.62 2.28 1.82 2.89 PLACE1003214 0.83 1.3 2 2.15 2.44 1.81 PLACE1003229 2.08 2.78 2.9 2.78 3.35 3.48 PLACE1003238 0.46 2.34 1.24 1.35 2 0.75 PLACE1003249 1.87 5.04 4.7 7.33 7.56 5.89 PLACE1003256 3.47 7.69 7.94 8.82 7.68 6.08 PLACE1003258 1.03 3.81 3.48 2.42 2.19 0.87 PLACE1003279 3.09 7.19 9.02 11.15 13.56 11.58 * + PLACE1003294 0.95 1.54 1.59 1.57 1.25 2.64 PLACE1003296 1.49 2.6 2.45 2.59 3.11 2.4 PLACE1003297 7.52 10.15 31.88 23.01 23.49 19.3 PLACE1003302 3.92 5.16 6.99 5.8 4.72 5.47 PLACE1003334 1.51 4.41 1.91 2.4 3.59 3.09 PLACE1003337 13.69 16.3 29.83 28.53 34.27 25.76 PLACE1003342 1.05 4.07 1.89 2.15 2.35 1.97 PLACE1003343 1.07 4.98 1.61 2.02 2.75 2.12 PLACE1003344 6.25 5.33 12.83 11.18 11.35 11.98 PLACE1003353 19.67 16.04 40.09 37.78 42.55 40.26 PLACE1003361 1.82 3.64 3.72 5.85 5.31 4.6 * + PLACE1003366 1.45 4.35 3.63 3.22 3.33 2.97 PLACE1003369 2.75 4.51 3.49 3.29 3.25 4.62 PLACE1003372 2.08 5.73 2.68 5.45 4.72 3.39 PLACE1003373 2.85 7.37 6.62 8.8 11.81 9.89 PLACE1003375 1.42 4.91 1.92 2.59 2.95 3.21 PLACE1003378 0.94 0.94 0.98 0.7 1.66 1.08 PLACE1003383 0.87 1.55 2.33 1.59 3.15 1.57 PLACE1003394 10.55 12.49 24.08 11.75 22.99 17.27 PLACE1003401 0.79 3.91 1.34 1.03 2.13 1.04 PLACE1003405 1.5 3.97 2.22 2.54 2.46 2.04 PLACE1003407 2.39 6.06 5.16 3.96 6.3 4.02 PLACE1003420 3.26 7.69 6.19 6.8 10.92 8.7 PLACE1003428 0.63 3.3 2.62 2.07 2.94 1.96 PLACE1003432 6.14 5.81 8.2 6.64 7.05 5.42 PLACE1003438 0.45 2.66 0.93 2.41 2.34 1.99 PLACE1003452 1.87 5.02 5.08 4.53 3.43 3.84 PLACE1003454 2.49 5.59 7.34 7.31 6.95 5.61 PLACE1003455 2.58 4.26 2.35 2.97 3.01 3.17 PLACE1003456 3.22 7.74 8.62 6.9 7.2 7.79 PLACE1003460 6.39 13.35 14.87 13.02 16.76 12.86 PLACE1003478 1.15 1.71 0.86 2.33 2.07 1.24 PLACE1003484 12.06 12.21 45.33 28.12 31.5 34.2 PLACE1003493 1.61 4.72 4.9 3.84 5.96 5.08 PLACE1003503 85.45 87.35 107.79 115.17 111.85 172.81 PLACE1003505 1.99 6.77 4.78 7.44 6.63 8.87 PLACE1003516 0.86 6.78 2.7 2.8 3.95 2.39 PLACE1003519 17.58 26.29 50.41 45.77 36.97 58.75 PLACE1003520 14.18 25.48 35.96 25.73 31.4 32.19 PLACE1003521 2.71 3.64 4.93 5.97 4.71 7.4 PLACE1003525 8.45 11.81 45.05 33.94 43.71 36.88 PLACE1003528 39.18 44.68 136.4 106.04 122.76 127.22 PLACE1003529 1.46 4.26 3.29 2.4 3.94 3.83 PLACE1003537 4.41 9.05 11.05 11.36 13.77 13.3 PLACE1003549 1.1 5.02 4.59 5.61 6.01 5.93 PLACE1003553 1.6 5.89 3.88 4.02 4.17 4.23 PLACE1003566 5.93 9.8 17.51 13.03 19.09 14.58 PLACE1003568 3.01 2.71 5.76 5.69 4.43 4.04 PLACE1003573 0.98 2.43 1.19 2.16 1.87 1.48 PLACE1003575 2.16 3.09 3.44 3.34 3.5 4.15 PLACE1003583 0.97 3.45 3.34 2.29 4.16 2.23 PLACE1003584 1.23 4.46 4.01 3.56 3.8 2.65 PLACE1003592 4.4 8.48 9.48 7.11 10.48 9.53 PLACE1003593 0.84 5.55 2.4 2.23 3.02 1.55 PLACE1003594 4.24 6.76 6.01 5.78 6.68 7.36 PLACE1003596 13.77 11.31 22.53 15.68 17.69 8.25 PLACE1003598 2.83 3.63 5.02 4.89 3.7 2.95 PLACE1003602 1.8 4.24 6.36 4.37 3.54 2.68 PLACE1003605 17.43 21.72 45.86 94.65 95.6 91.55 ** + PLACE1003611 2.34 5.18 6.07 5.65 7.14 6 PLACE1003618 0.67 7.39 2.09 1.58 2.4 1.32 PLACE1003625 1.78 10.41 2.75 3.33 5.48 2.8 PLACE1003626 8.77 15.99 17.14 10.87 14.46 13.19 PLACE1003630 1.8 2.57 5.8 7.05 4.67 5.86 PLACE1003635 2.15 1.83 3.19 2.96 2.82 2.44 PLACE1003638 1.3 2.58 3 5.21 4.19 3.13 PLACE1003644 4.01 5.7 7.25 7.81 9.13 8.76 * + PLACE1003654 2.56 6.14 4.04 3.54 6.96 6.4 PLACE1003656 2.69 7.79 6.12 6.54 5.63 4.77 PLACE1003660 0.26 9.54 3.5 3.08 4.92 4.11 PLACE1003669 2.43 9.05 3.67 2.59 4.26 3.08 PLACE1003670 5.37 5.7 9.44 11.01 8.26 8.76 PLACE1003671 1.66 1.22 3.57 3.11 2.57 1.57 PLACE1003697 7.27 7.99 9.8 8.23 6.06 6.42 PLACE1003704 3.12 3.97 5.17 5.96 7.25 5.97 * + PLACE1003709 0.89 2.63 0.8 1.19 1.24 2.44 PLACE1003711 0.74 5.48 1.35 1.87 1.8 1.39 PLACE1003723 1.07 6.99 4.7 4.2 5.31 4.16 PLACE1003724 3.31 10.74 9.1 9.11 11.79 10.49 PLACE1003737 2.14 2.21 4.72 3.35 3.1 3.29 PLACE1003738 1.06 1.94 3.13 3.96 3.92 3.41 PLACE1003742 2.25 3.58 5.71 6.81 6.18 2.85 PLACE1003744 6.13 8.86 14.6 16.21 17.96 19.13 * + PLACE1003758 0.85 4.55 0.96 2 1.46 1.16 PLACE1003760 13.44 18.68 27.23 31.82 20.52 22.79 PLACE1003762 1.45 4.97 3.7 3.77 3.78 3.49 PLACE1003765 1.18 5.23 3.45 2.01 3.1 2.11 PLACE1003768 0.36 1.14 1.36 1.45 2.75 1.07 PLACE1003771 1.28 1.94 2.07 1.84 3.13 1.43 PLACE1003772 34.15 38.19 97.86 62.42 64.06 52.43 PLACE1003783 1.48 3.02 2.22 18.65 19.53 16.61 ** + PLACE1003784 0.69 3.92 0.87 2.09 2.19 2.68 PLACE1003788 0.4 4.92 1.06 1.85 1.71 0.32 PLACE1003795 1.01 4.1 3.57 4.73 4.38 3.54 PLACE1003827 13.83 20.46 20.72 22.48 30.84 25.92 PLACE1003833 0.98 1.49 3.9 3.65 4.33 3.31 PLACE1003839 22.55 19.18 52.95 50.39 56.11 43.86 PLACE1003845 6.09 6.88 11.72 24.98 19.99 10.6 PLACE1003850 3.16 4.84 7.19 5.45 5.95 6.39 PLACE1003852 0.25 3.36 1.09 0.99 1.58 1.05 PLACE1003858 1.34 4.42 1.99 2.04 1.85 2.92 PLACE1003861 0.95 4.51 1.63 2.98 2.78 1.73 PLACE1003864 0.94 5.5 2.74 2.88 3.86 2.69 PLACE1003870 3.84 3.4 13.2 10.71 16.12 12.03 PLACE1003885 1.33 1.42 1.59 3.07 3.76 2.38 * + PLACE1003886 4.56 6.01 5.75 9.27 6.87 4.3 PLACE1003888 0.75 3.79 1.96 2.87 3.42 2.68 PLACE1003892 4.93 6.91 20.79 17.21 22.33 14.87 PLACE1003900 2.27 5.92 7.17 6.34 9.75 6.6 PLACE1003902 1.91 7.39 5.25 5.43 8.07 6.29 PLACE1003903 0.42 5.07 2.94 2.55 3.5 2.59 PLACE1003915 8.15 7.04 10.78 8.31 9.79 9.84 PLACE1003918 1.88 2.45 4.75 3.47 6.26 3.75 PLACE1003923 2.06 3.73 5.63 2.7 5.54 3.32 PLACE1003932 3.99 5.16 5.47 4.06 7.58 5.09 PLACE1003936 1.02 3.82 2.81 3.63 2.42 2.78 PLACE1003966 3.11 7.43 7.76 4.89 7.32 4.21 PLACE1003968 1.68 5.68 5.94 3.33 4.26 4.57 PLACE1004018 25.49 33.73 48.16 32.56 40.53 28.62 PLACE1004020 8.91 10.18 13.26 11.42 18.03 24.15 PLACE1004028 0.41 2.55 1.3 1.38 1.23 1.91 PLACE1004034 3.56 4.53 5.22 8.42 9.03 13.04 * + PLACE1004042 17.25 20.19 68.35 79.51 93.32 79.44 * + PLACE1004078 1.14 4.1 3.3 4.95 6.51 4.45 PLACE1004103 5.54 10.93 13.98 13.77 15.09 14.14 PLACE1004104 5.94 12.29 27.78 24.18 34.98 29.71 PLACE1004113 1.37 3.7 3.28 2.75 3.27 1.29 PLACE1004114 1.12 2.55 2.23 2.84 2.49 2.93 PLACE1004118 1.58 3.52 2.09 2.74 3.64 2.5 PLACE1004128 4.4 6.84 5.66 6.61 8.13 9.01 PLACE1004130 2.25 4.83 8.35 6.86 9.26 6.73 PLACE1004149 3.59 7.3 9.86 10.23 13.29 10.12 PLACE1004156 3.61 7.91 10.12 11.66 17.62 13.31 PLACE1004160 5.45 9.54 14.36 13.1 19.65 14.53 PLACE1004161 2.2 4.86 3.54 4.85 5.73 7.48 PLACE1004166 5.61 5.81 9.91 8.3 8.66 11.2 PLACE1004168 3.35 4.97 3.73 4.73 6.65 6.79 PLACE1004170 0.78 3.28 1.93 2.98 3.42 2.76 PLACE1004178 0.83 5.23 2.37 2.4 2.59 2.36 PLACE1004183 0.89 7.99 4.41 3.53 4.32 4.84 PLACE1004197 0.64 5.14 1.55 1.73 3.54 1.65 PLACE1004199 1.66 4.52 4.09 3.78 5.88 4.35 PLACE1004203 1.8 3.57 4.17 2.43 3.62 2.83 PLACE1004242 3.8 5.64 11.04 8.55 8.14 8.64 PLACE1004249 31.4 56.31 117.88 127.93 152.54 151.22 * + PLACE1004255 0.79 2.65 1.26 2.59 2.15 1.93 PLACE1004256 9.06 11.68 13.63 14.66 14.18 23.37 PLACE1004257 2.63 7.95 6.48 7.89 8.8 8.64 PLACE1004258 1.87 5.21 3.13 4.59 3.15 3.11 PLACE1004270 0.72 3.8 2.5 2.7 4.01 1.65 PLACE1004272 1.34 3.68 3.73 3.86 5.38 6.15 PLACE1004273 92.91 89.59 212.62 212.05 129.56 99.82 PLACE1004274 2.09 3.61 6.51 6.42 7.14 6.74 PLACE1004277 2.3 4.4 5.76 6.45 7.7 6.04 PLACE1004279 0.54 3.39 2.23 3.16 2.64 2.02 PLACE1004282 2.43 8.25 6.62 4.22 5.56 4.49 PLACE1004284 4.59 11.31 7.84 7.38 8.16 7.15 PLACE1004289 1.28 7.85 2.46 3.06 3.63 2.1 PLACE1004299 0.33 6.41 1.38 1.54 2.67 1.83 PLACE1004302 1.01 2.98 3.27 2.41 2.45 1.12 PLACE1004305 1.11 2.09 1.9 1.9 1.82 1.78 PLACE1004316 2.3 4.48 5.4 6.06 3.85 4.52 PLACE1004322 2.49 3.41 5.25 6.35 7.14 5.75 * + PLACE1004325 2.43 6.38 3.84 3.85 3.66 4 PLACE1004332 1.21 7.18 2.8 3.72 3.46 3.01 PLACE1004336 2.87 9.6 5.36 6.88 9.21 6.71 PLACE1004346 0.47 7.22 2.58 1.87 2.54 1.69 PLACE1004358 1.3 2.41 2.41 2.46 2.09 2.03 PLACE1004376 11.07 10.15 23.35 19.16 17.04 16.46 PLACE1004384 0.65 3.46 1.46 1.92 2.48 2.1 PLACE1004385 1.4 2.89 1.69 3.52 1.88 2.67 PLACE1004388 1.79 5.73 4.27 3.44 4.87 3.04 PLACE1004405 2.16 8.39 4.42 13.36 14.48 16.74 ** + PLACE1004407 5.05 13.12 13.37 11.2 16.24 11.85 PLACE1004424 0.37 5.78 0.85 1.7 1.81 1.58 PLACE1004425 1.14 1.94 3.57 3.28 3.27 3.44 PLACE1004427 1.96 3.31 4.56 4.67 4.22 3.24 PLACE1004428 0.88 2.05 2.17 2.66 2.08 2.62 PLACE1004433 5.7 8.3 10.82 12.94 15.67 12.05 * + PLACE1004435 0.72 4.17 1.43 1.95 1.9 2.15 PLACE1004437 4.05 7.68 14.2 11.07 13.01 12.37 PLACE1004441 7.82 11.68 34.06 30.75 43.19 26.41 PLACE1004446 1.5 4.36 0.9 1.03 1.35 1.39 PLACE1004450 0.33 1.46 1.34 2.57 1.71 0.7 PLACE1004451 0.51 1.45 2.14 1.89 2.69 0.88 PLACE1004456 8.22 9.7 10.97 16.68 10.4 4.18 PLACE1004458 3.39 4.81 3.66 7.77 7.05 8.24 ** + PLACE1004460 0.84 4.58 2.1 2.91 2.69 1.75 PLACE1004467 5.31 6.81 10.65 7.67 10.14 10.48 PLACE1004471 2.65 5.93 6.64 6.79 7.34 6.14 PLACE1004473 1.16 4.66 3.5 3.18 3.23 3.21 PLACE1004475 14.03 16.41 32.49 31.09 32.51 18.17 PLACE1004482 8.37 6.7 10.79 10.04 9.76 9.15 PLACE1004491 0.39 2.51 1.49 1.19 2.68 1.3 PLACE1004492 61.52 74.8 127.94 129.92 127.64 123.82 PLACE1004506 10.71 14.35 14.4 8.45 11.13 10.03 PLACE1004507 2.9 7.37 5.09 7.15 6.87 6.18 PLACE1004510 2.51 6.23 6.33 6.59 7.8 8.16 PLACE1004516 0.98 7.36 2.12 2.79 3.78 2.22 PLACE1004518 1.64 1.78 3.03 2.41 3.88 2.83 PLACE1004519 0.17 0.82 0.62 1.43 2.79 1.51 * + PLACE1004520 6.08 8.09 10.06 7.44 9.11 2.52 PLACE1004530 33.19 43.86 68.13 41.86 27.72 38.09 PLACE1004545 1.13 3.83 2.12 3.03 3.31 3.65 PLACE1004547 5 7.61 7.82 8.66 11.2 10.28 PLACE1004548 1.69 6.73 4.43 6.93 8.48 6.5 PLACE1004550 2.27 6.24 6.67 5.92 6.78 6.15 PLACE1004551 0.8 2.16 1.62 2.14 2.21 1.95 PLACE1004559 2.9 2.89 5.11 4.45 6.75 4.82 PLACE1004562 8.67 11.27 16.07 13.01 14.38 13.34 PLACE1004564 1.84 5.19 4.36 4.64 5.98 4.49 PLACE1004604 1.69 4.21 9.88 2.49 4.34 1.97 PLACE1004611 2.73 5.87 4.89 3.86 4.17 3.99 PLACE1004629 9.42 15.75 19.92 23.93 30.49 29.01 * + PLACE1004630 16.66 20.82 35.1 16.76 23.04 19.17 PLACE1004637 5.03 8.82 10.34 6.61 9.17 8.29 PLACE1004645 36.5 39.28 92.04 85.16 87.94 74.59 PLACE1004646 1.07 2.91 2.87 3.68 2.19 2.28 PLACE1004648 0.8 3.42 2.52 2.53 3.15 1.22 PLACE1004655 45.95 58.09 130.94 112.14 126.25 99.01 PLACE1004658 2.4 7.34 6.31 6.64 8.37 6 PLACE1004664 1.26 4.83 1.3 3.02 2.65 1.89 PLACE1004672 2.32 6.79 8.02 6.3 7.51 7.14 PLACE1004674 9.4 11.97 14.7 8.3 9.75 15.25 PLACE1004681 1.97 3.84 5.62 5.05 5.69 4.39 PLACE1004686 2.74 4.33 7.46 9.22 10.77 8.59 * + PLACE1004690 10.64 13.43 19.62 21.75 19.21 31.72 PLACE1004691 1.14 6.71 3.71 2.92 4.13 2.75 PLACE1004693 1.34 7.54 4.89 3.91 4.59 5.97 PLACE1004701 13.01 18.45 24.24 25.21 24.46 25.1 PLACE1004705 1.29 3.33 2.27 1.8 1.96 1.47 PLACE1004708 37.69 46.37 80.19 41.34 39.66 50.98 PLACE1004716 6.37 8.81 11.08 4.22 12.55 14.26 PLACE1004722 1.31 3.05 2.6 2.26 3.28 2.51 PLACE1004736 5.25 7.71 7.6 9.16 8.89 11.63 PLACE1004737 5.42 12.71 16.14 8.15 11.23 13.78 PLACE1004740 4.88 9.06 8.22 7.37 7.93 8.2 PLACE1004743 1.31 4.04 3.1 1.97 4 3.55 PLACE1004751 0.98 2.89 2.88 2.75 3.74 3.06 PLACE1004757 3.45 4.34 10.53 8.4 9.6 7.22 PLACE1004761 6.41 7.32 12.59 9.99 10.44 9.72 PLACE1004773 1.05 2.34 1.7 1.94 2.31 2.72 PLACE1004775 0.35 3.26 1.37 1.29 2.14 1.07 PLACE1004777 2.1 7.57 2.97 3.68 4.25 4.4 PLACE1004793 0.83 4.58 1.37 1.9 2.06 1.25 PLACE1004796 6.65 8.7 13.08 7.79 8.57 7.88 PLACE1004804 0.99 4.46 3.25 2.44 2.38 3.22 PLACE1004813 4.55 7.11 9.84 6.45 5.19 5.45 PLACE1004814 7.16 11.76 17.62 15.83 11.39 10.1 PLACE1004815 0.7 2.81 2.43 3.12 2.61 3.44 PLACE1004816 1.16 2.63 2.04 2.36 2.26 1.84 PLACE1004824 3.25 7.37 5.27 8.1 9.13 8.85 PLACE1004827 1.4 10.89 3.17 2.57 3.05 1.3 PLACE1004836 1.72 12.95 4.26 6.25 7.99 4.49 PLACE1004838 1.35 8.81 2.2 2.49 2.34 1.68 PLACE1004840 1.59 2.06 2.21 1.85 2.08 1.37 PLACE1004842 0.86 1.98 1.89 1.98 1.78 2.33 PLACE1004850 0.81 2.35 1.63 1.83 2.76 2.36 PLACE1004868 0.81 2.97 2.04 1.62 2.23 2 PLACE1004885 1.5 7.09 3.51 3.4 6.03 4.77 PLACE1004886 1.87 8.53 2.76 3.33 5.12 4.93 PLACE1004887 18.14 34.01 58.51 36.9 38.66 30.33 PLACE1004896 8.39 14.15 15.4 9.39 11.14 14.03 PLACE1004900 1.75 2.7 6.69 5.66 5.74 4.44 PLACE1004902 5.42 6.25 9.27 6.39 4.2 3.6 PLACE1004904 1.7 4.66 2.52 6.49 4.78 3.03 PLACE1004911 0.69 2.5 1.12 5.95 4.82 6.09 ** + PLACE1004913 3.63 5.72 7.38 4.49 5.45 4.79 PLACE1004918 1.3 6.69 2.05 2.39 3.24 2.64 PLACE1004930 2.74 8.84 5.93 10.63 16.57 14.71 * + PLACE1004934 1.14 4.3 3.34 2.97 2.03 2.5 PLACE1004937 2.1 4.03 4.91 2.74 3.59 2.36 PLACE1004949 4.32 4.98 7.67 8.53 8.48 6.04 PLACE1004969 0.74 1.74 1.99 1.39 2.34 1.4 PLACE1004970 0.45 2.18 1.2 1.43 1.31 1.01 PLACE1004972 1.63 6.56 2.69 5.66 3.17 4.76 PLACE1004974 1.27 5.21 4.2 5.6 5.7 5.62 PLACE1004975 0.59 2.84 1.11 1.94 1.98 1.24 PLACE1004979 1.58 4.06 4.26 4.91 5.69 4.75 PLACE1004982 5.66 6.45 9.74 10.03 10.67 5.65 PLACE1004985 1.4 1.47 1.46 2.5 2.17 1.2 PLACE1005003 2.85 4.22 6 6.05 6.37 5.78 PLACE1005004 0.47 3.36 0.92 1.5 0.73 0.85 PLACE1005005 3.35 6.9 5.32 6.67 9.65 7.17 PLACE1005011 6.03 11.12 35.8 37.66 56.97 36.62 PLACE1005026 0.79 4.18 2.29 2.44 2.49 2.16 PLACE1005027 2.46 6.72 6.69 5.36 6.92 5.68 PLACE1005031 1.21 1.47 3.69 5.72 7.1 4.6 * + PLACE1005036 2.27 3.6 6.83 9.08 8.91 7.53 * + PLACE1005041 2.5 2.84 2.84 5.05 4.41 3.25 * + PLACE1005046 2.23 4.11 4.56 6.04 3.92 4.33 PLACE1005047 0.23 3.19 2.6 1.43 1.23 2.1 PLACE1005052 4.24 8.53 6.36 8.08 8.15 8.1 PLACE1005055 2.54 7.45 4.66 7.2 6.45 5.62 PLACE1005066 4.33 8.26 7.58 12.9 14.14 16.49 ** + PLACE1005077 1.17 0.68 1.2 2.1 2.43 1.54 * + PLACE1005085 1.41 1.97 3.06 3.34 4.14 3.45 PLACE1005086 1.93 3.77 5.17 5.62 7.78 4.79 PLACE1005088 24.66 32.47 46.03 43.45 31.47 27.46 PLACE1005089 1.57 4.78 3.15 2.52 3.67 3.14 PLACE1005101 3.37 8.11 5.46 6.11 8.96 6.39 PLACE1005102 2.56 7.14 5.01 4.11 5.51 3.8 PLACE1005108 2 6.08 5.87 6.58 6.19 5.09 PLACE1005110 1.34 1.89 3.08 1.75 2.75 2.15 PLACE1005111 1.31 1.34 1.23 1.45 2.17 1.54 PLACE1005123 26.23 26.21 47.58 34.26 49.34 34.98 PLACE1005124 3.2 4.66 4.18 4.2 6.91 5.44 PLACE1005128 9.54 8.89 18.22 16.37 16.36 16.13 PLACE1005130 2.65 6.57 5.54 2.84 4.98 3.58 PLACE1005141 6.3 9.92 11.25 16.15 20.75 18.95 ** + PLACE1005146 1.3 2.71 3.03 2.17 2.53 2.29 PLACE1005152 1.85 3.9 4.56 4.13 4.23 4.79 PLACE1005157 2.66 5.19 5.3 4.38 4.09 7.01 PLACE1005162 2.79 3.72 9.31 6.57 7.45 7.1 PLACE1005170 17.34 18.92 29.76 21.38 18.18 23.73 PLACE1005176 0.57 5.6 1.7 2.33 2.47 1.94 PLACE1005181 0.53 5.14 0.96 0.89 1.36 0.37 PLACE1005184 4.06 9.09 10.4 8.97 12.82 11.26 PLACE1005186 3.5 3.41 8.56 8.05 5.79 5.73 PLACE1005187 2.85 4 4.13 6.1 4.99 4.25 PLACE1005189 6.12 7.71 5.34 10.84 10.65 12.22 ** + PLACE1005193 1.48 3.78 1.71 3.84 2.91 2.61 PLACE1005200 1.35 4.68 2.61 2.47 3.75 3.1 PLACE1005206 2.43 6.48 4.26 3.35 3.95 2.95 PLACE1005216 1.53 5.46 4.44 5.6 6.51 4.12 PLACE1005223 1.43 6.21 5 4.38 5.66 3.27 PLACE1005225 1.36 3.01 3.49 3.33 3.32 4.65 PLACE1005232 1.86 3.31 4.87 5.63 6.19 3.88 PLACE1005239 1.06 4.3 2.32 2.84 2.86 2.41 PLACE1005243 4.35 7.32 5.41 8.48 7.49 10.75 PLACE1005250 4.24 10.31 7.98 4.38 5.9 8.88 PLACE1005261 3.21 7.43 4.74 4.78 5.82 3.51 PLACE1005266 1.05 4.47 2.82 2.28 4.43 2.76 PLACE1005271 4.66 5.31 8.79 5.87 11.16 7.95 PLACE1005277 2.06 3.48 2.35 2.62 1.98 2.64 PLACE1005287 3.63 4.31 5.87 2.98 5.06 6.91 PLACE1005299 24.16 22.75 48.29 35.17 24.24 41.06 PLACE1005305 6.81 8.46 11.13 10.67 11.85 16.25 PLACE1005307 1.59 5.44 4.14 3.15 5.42 4.84 PLACE1005308 2.41 4.96 3.95 5.32 5.99 5.79 PLACE1005313 1.08 3.83 1.6 1.8 2.05 1.8 PLACE1005320 1.36 3.65 3.34 3.39 4.05 2.26 PLACE1005327 10.78 8.74 16.8 10.36 7.95 4.43 PLACE1005331 2.28 4.92 5.28 4.66 4.97 3.33 PLACE1005335 1.53 3.8 2.24 2.03 3.22 2.42 PLACE1005336 9.12 12.58 16.58 16.39 16.99 20.15 PLACE1005351 2.62 8.18 10.17 9.28 8.66 9.52 PLACE1005366 2.04 6.93 3 2.99 3.71 4.23 PLACE1005373 1.77 6.34 4.44 3.91 5.36 3.37 PLACE1005374 3.29 9.47 11.4 7.35 10.22 12.41 PLACE1005383 8.16 7.54 12.81 7.21 5.93 4.03 PLACE1005388 0.33 2.04 1.56 1.92 3.67 2.2 PLACE1005409 2.97 5.02 4.99 3.9 4.23 2.97 PLACE1005410 12.41 16.44 18.89 24.38 20.98 27.1 * + PLACE1005426 5.16 7.48 9.06 5.51 7.67 5.45 PLACE1005431 12.6 15.65 22.53 19.64 26.25 23.75 PLACE1005453 1.4 10.38 3.93 4.85 4.45 3.28 PLACE1005467 3.09 11.87 7 5.57 11.63 7.28 PLACE1005471 1.6 1.94 1.66 2.29 1.52 1.28 PLACE1005476 0.42 1.73 1.24 1.6 1.57 1.46 PLACE1005477 1.58 2.26 2.51 3 2.93 2.74 PLACE1005480 0.77 2.01 1.86 1.93 1.4 0.53 PLACE1005481 0.44 4.81 2.3 2.77 3.62 2.44 PLACE1005494 0.27 6.66 1.68 1.21 1.73 1.06 PLACE1005495 3.86 12.83 8.31 6.85 9.25 7.62 PLACE1005497 2.27 7.72 3.95 4.24 5.68 5.91 PLACE1005499 5.71 5.86 11.07 10.82 7.9 6.49 PLACE1005502 1.59 2.87 3.43 4.07 3.45 1.49 PLACE1005513 1.77 4.14 3.35 1.86 2.85 1.98 PLACE1005515 2.89 4.76 4.22 4.58 5.29 3.78 PLACE1005519 1.04 4.53 3.29 2.85 2.85 2.83 PLACE1005526 0.58 5.55 1.38 1.3 1.59 0.71 PLACE1005528 2.08 7.71 5.57 5.94 7.12 5.33 PLACE1005530 2.16 7.09 4.32 5.17 8.23 4.67 PLACE1005536 1.74 1 2.74 3.12 2.43 2.88 PLACE1005539 10.1 11.64 23.77 8.65 8.66 5.22 PLACE1005543 1.7 3.57 5.62 3.54 4.32 2.57 PLACE1005544 0.86 3.26 3.15 2.49 2.68 2.27 PLACE1005550 4.32 7.61 7.85 10.16 7.25 6.86 PLACE1005554 1.15 5.47 2.67 2.17 2.17 1.17 PLACE1005557 1.76 7.21 4.95 8.22 7.64 7.7 PLACE1005563 0.51 4 1.89 1.45 2.07 1.06 PLACE1005569 0.6 0.5 1.56 1.59 1.81 1.09 PLACE1005574 1.07 1.88 2.49 2.48 4.43 2.22 PLACE1005584 1.3 2.68 3.91 3.91 5.58 3.03 PLACE1005590 4.28 5.14 8.4 9.87 10.73 8.02 PLACE1005595 3.08 4.03 2.89 3.65 3.81 3.89 PLACE1005601 2 5.66 4.22 3.77 4 4.02 PLACE1005603 1.08 4.9 1.04 2.49 0.95 1.94 PLACE1005604 1.2 6.71 2.42 3.6 4.2 3.46 PLACE1005611 2.22 2.3 3.98 5.15 5.65 2.89 PLACE1005622 0.65 1.71 1.98 2.94 3.88 1.26 PLACE1005623 1.42 3.08 3.27 3.71 3.65 1.61 PLACE1005630 3.31 5.81 7.75 87.83 72.15 89.12 ** + PLACE1005639 0.75 4.36 1.28 1.66 2.02 1.18 PLACE1005646 2.13 5.41 4.31 5.4 5.08 2.55 PLACE1005647 2.77 9.69 6.72 7.34 9.11 6.25 PLACE1005648 3 8.11 9.21 8.34 10.59 8.22 PLACE1005653 1.99 1.43 2.74 2.74 2.13 2.67 PLACE1005656 0.92 2.48 2.24 1.68 2.78 1.58 PLACE1005659 0.87 2.64 1.01 1.62 1.84 1.32 PLACE1005660 3.91 8.03 5.77 8.87 8.88 8.34 PLACE1005664 2.69 6.57 6.14 3.39 4.27 3.19 PLACE1005666 0.89 5.91 3.55 4.63 4.93 3.97 PLACE1005669 4.46 10.41 11.39 11.64 13.9 14.6 PLACE1005682 1.94 5.27 4.49 6.2 5.2 5.47 PLACE1005698 0.6 2.7 2.92 2.01 2.67 2.38 PLACE1005708 25.32 34.08 53.46 53.89 59.98 53.76 PLACE1005725 3.25 3.75 6.41 5.64 5.82 7.29 PLACE1005727 2.97 4.54 4.15 3.9 3.49 4 PLACE1005730 0.77 4.29 3.26 1.1 1.54 1.28 PLACE1005736 5.37 7.55 5.73 9.25 12.55 10.19 * + PLACE1005739 0.81 4.96 1.38 2.46 3.17 1.74 PLACE1005745 8.03 7.11 11.52 11.98 6.97 11.44 PLACE1005752 1.31 3.15 2.96 2.55 2.24 1.25 PLACE1005755 0.8 2.79 3.02 1.72 3.28 2.27 PLACE1005756 10.79 12.06 17.2 18.22 19.3 21.47 * + PLACE1005760 10.22 15.24 68.06 49.69 68.81 53.09 PLACE1005763 1.47 7.04 3.58 3.79 4.63 3.02 PLACE1005768 1.25 5.63 3.69 4.58 5.13 4.19 PLACE1005771 5.71 13.63 13.7 11.28 17.49 17.27 PLACE1005783 1.82 2.44 3.64 3.05 3.71 3.47 PLACE1005799 4.79 5.25 8.37 6.12 8.78 8.62 PLACE1005802 1.07 3.78 3.64 2.7 3.64 1.96 PLACE1005803 3.06 6.15 4.78 5.6 4.94 7.36 PLACE1005804 0.92 8.41 1.33 2 1.91 2.44 PLACE1005813 17.23 18.71 78.06 70.01 94.17 74.89 PLACE1005815 1.43 5.6 4.38 3.8 5.01 4.1 PLACE1005828 2.11 3.62 4.42 5.34 6.24 3.56 PLACE1005833 119.17 92.82 182.22 122 114.37 107.96 PLACE1005834 2.04 4.33 3.95 3.55 3.56 2.56 PLACE1005835 22.7 19.1 51.52 72.32 60.34 68.56 * + PLACE1005836 2.39 4.21 4.97 2.61 3.83 2.55 PLACE1005845 0.97 5.42 2.66 2.67 3.05 3.65 PLACE1005850 1.82 3.91 3.04 2.84 2.85 2.15 PLACE1005851 1.03 3.44 1.46 1.2 2.01 1.11 PLACE1005856 0.92 4.01 2.42 2.24 3.37 3.37 PLACE1005875 1.78 3.89 4.77 3.3 3.48 3.17 PLACE1005876 1.33 3.99 4.76 6.87 6.34 6.9 * + PLACE1005878 1.3 2.67 2.08 3.54 4.46 2.79 PLACE1005880 2.36 4.09 4.31 4.16 3.07 3.45 PLACE1005884 1.6 4.87 1.89 2.48 2.21 2.73 PLACE1005890 1.9 9.57 3.7 2.26 3.09 1.88 PLACE1005898 3.29 10.87 5.34 7.36 8.12 6.36 PLACE1005913 1.46 9.31 8.05 4.99 6.47 4.33 PLACE1005921 0.99 1.92 2.03 1.49 2.22 0.79 PLACE1005923 0.74 1.61 1.17 1.47 2.42 1.43 PLACE1005925 0.83 2.67 3.18 2.19 2.14 1.68 PLACE1005927 1.26 2.49 1.93 1.95 2.56 2.3 PLACE1005932 2.04 5.66 2.44 2.53 2.32 2.52 PLACE1005934 0.88 7.91 3.16 3.9 5.61 4.19 PLACE1005936 1.31 8.96 3.02 2.02 2.84 2.3 PLACE1005939 54.61 68.58 111.22 157.61 194.58 212.18 ** + PLACE1005951 2.36 3.39 4.98 5.56 4.48 2.35 PLACE1005953 1.5 1.64 2.64 2.59 2.43 3.03 PLACE1005955 1.64 2.01 3.8 4.07 3.43 2.55 PLACE1005966 0.76 3.42 1.69 1.75 2 2.19 PLACE1005968 1.52 4.96 3.2 4.71 5.15 6.12 PLACE1005975 2.58 7.11 5.42 6.18 7.01 6.49 PLACE1005990 0.7 7.7 1.54 2.1 1.87 0.88 PLACE1005997 88.15 118.52 196.48 189.6 226.97 172.1 PLACE1006002 3.38 3.97 8.87 8.4 7.71 9.18 PLACE1006003 1.55 3.02 4.83 5.09 4.44 5.33 PLACE1006011 1.85 3.63 3.46 4.48 2.68 1.91 PLACE1006017 0.84 2.74 2.81 3.4 3.4 3.58 PLACE1006037 2.99 7.05 2.48 6.14 3.64 4.29 PLACE1006040 2.2 7.87 3.97 6.64 6.9 7.77 PLACE1006063 0.94 4.64 2.59 2.11 3.15 2.25 PLACE1006071 3.06 6.52 4.97 5.36 4.03 4.47 PLACE1006073 2.74 3.53 6.43 7.19 6.81 6.93 PLACE1006074 1.4 2.22 3.34 2.62 3.23 1.69 PLACE1006076 1.36 2.51 2.98 3.15 2.47 2.75 PLACE1006079 1.38 4.32 1.78 2.1 1.1 1.11 PLACE1006093 0.49 3.76 1 3.56 3.85 1.83 PLACE1006116 2.99 6.44 4.04 5.28 5.01 4.91 PLACE1006119 3.15 6.81 7.07 9.22 10.4 8.03 PLACE1006129 2.12 5.6 3.98 6.59 7.62 5.65 PLACE1006139 3.44 2.98 6.03 7.77 8.85 5.58 PLACE1006143 0.5 1.48 1.87 3.18 4.13 3.17 * + PLACE1006157 1.55 2.54 4.82 2.96 3.9 2.44 PLACE1006159 0.69 3.61 0.94 2.68 1.98 1.04 PLACE1006164 0.35 3.18 1.37 1.73 1.85 1.21 PLACE1006167 2.18 6.5 3.37 3.95 4.52 3.13 PLACE1006170 2.79 6.09 6.09 4.34 5.31 3.68 PLACE1006181 2.75 7.34 2.84 5.8 5.51 5.22 PLACE1006187 0.76 1.3 2.15 2.01 2.41 1.48 PLACE1006195 0.11 1.24 1.73 1.93 1.93 0.87 PLACE1006196 1.8 4.01 4.15 4.32 5.77 2.19 PLACE1006197 2.12 5.6 5.24 4 3.47 3.39 PLACE1006198 0.27 3.68 1.21 0.84 1.63 0.5 PLACE1006205 0.89 5.59 0.99 2.43 2.18 1.28 PLACE1006208 7.28 13.32 13.46 14.09 14.99 12.5 PLACE1006211 2.6 8.05 7.92 6.07 9.08 9.35 PLACE1006219 6.77 5.77 8.94 14.88 22.25 15.35 * + PLACE1006223 1.55 1.46 3.19 1.39 3 1.64 PLACE1006225 0.56 2.27 1.3 1.04 2.3 0.99 PLACE1006236 1.53 3.2 2.92 3.06 5.01 2.29 PLACE1006239 0.67 3.62 1.97 2.61 3.66 3.41 PLACE1006245 3.86 7.13 5.45 4.43 7.44 3.28 PLACE1006246 1.66 6.56 6.19 5.59 7.66 6.33 PLACE1006248 1.58 4.47 5.6 2.77 3.1 2.82 PLACE1006262 0.93 2.24 1.49 2.08 1.61 1.4 PLACE1006269 2.28 4.71 3.42 2.06 2.47 2.33 PLACE1006275 1.6 3.57 3.37 4.12 3.68 3.53 PLACE1006277 1.01 2.42 1.4 1.79 3.01 0.88 PLACE1006288 9.32 13.59 22.49 26.85 18.4 25.21 PLACE1006290 1.79 6.81 5.99 8.87 7.56 9.13 PLACE1006298 1.93 5.52 2.47 3.87 5.08 4.55 PLACE1006311 0.65 3.38 1.75 225.97 161.43 251.12 ** + PLACE1006318 3.52 4.03 4.17 4.04 3.17 4.01 PLACE1006325 5.43 6.73 6.31 8.09 8.38 8.08 ** + PLACE1006331 1.87 3.36 3.21 4.44 3.59 2.56 PLACE1006335 1.76 3.64 2.55 4.45 2.98 2.92 PLACE1006357 0.27 4.51 1.59 1.7 1.49 1.2 PLACE1006360 1.1 5.11 1.79 2.46 2.74 2.62 PLACE1006364 4.51 8.06 7.29 7.37 9.19 5.75 PLACE1006365 1.68 4.65 1.97 1.8 2.12 0.97 PLACE1006368 1.53 3.11 2.57 3.01 3.04 4.27 PLACE1006371 1.38 3.2 1.46 1.68 3.01 1.67 PLACE1006373 2.21 5.21 5.75 7.83 8.02 7.56 * + PLACE1006382 0.9 4.67 2.81 3.3 1.92 2.95 PLACE1006385 1.59 6.33 1.86 2.68 2.59 2.71 PLACE1006391 1.19 5 1.95 1.96 2.79 1.63 PLACE1006412 1.88 5.53 5.92 7.07 9.93 5.27 PLACE1006414 0.63 3.42 0.95 1.22 1.87 1.6 PLACE1006419 7.79 9.8 11.93 5.19 7.29 5.32 * - PLACE1006438 0.99 6.07 3.42 3.29 4.56 5.14 PLACE1006443 2.05 5.01 5.12 5.01 5.31 6.44 PLACE1006445 0.84 5.76 3.65 3.53 3.27 3.55 PLACE1006447 1.34 5.81 3.28 2.95 3.26 3.96 PLACE1006466 0.75 4.38 1.35 1.49 1.66 1.08 PLACE1006469 0.67 4.66 2.31 1.65 2.26 1.67 PLACE1006470 2.47 3.71 3.74 5.25 7.02 4.35 PLACE1006472 24.4 23.44 52.17 26.23 28.52 9.36 PLACE1006476 2.52 4.31 8.67 6.21 7.23 5.93 PLACE1006482 1.64 3.35 4.43 4.25 4.67 4.98 PLACE1006488 14.12 19.42 32.69 40.76 34.77 41.4 * + PLACE1006492 2.03 6.41 4.38 4.04 4.98 3.02 PLACE1006506 1.78 6.67 4.04 4.41 5.71 4.17 PLACE1006515 1.65 5.7 3.08 3.19 2.84 4.08 PLACE1006516 1.1 7.32 7.05 4.89 5.69 7.28 PLACE1006520 1.02 2.74 2.12 1.19 3 1.54 PLACE1006521 2.4 3.54 6.38 6.49 6.86 5.08 PLACE1006529 5.96 7.35 6.96 10.56 8.2 7.93 PLACE1006531 1.01 4.31 3.33 1.84 2.05 2.43 PLACE1006534 1.68 6.04 2.59 3.01 3.86 3.19 PLACE1006540 2.68 9.7 7.77 8.71 11.21 4.46 PLACE1006549 0.6 9.45 2.09 1.6 2.28 1.65 PLACE1006550 1.76 8.82 4.07 2.77 2.94 4.14 PLACE1006552 1.3 2.48 2.14 1.97 1.3 0.81 PLACE1006557 2.38 4.01 3.79 2.84 2.51 2.45 PLACE1006563 2.49 3.44 5.7 4.23 4.15 4.3 PLACE1006579 1.53 7.5 4.82 4.88 5.38 5.78 PLACE1006594 236.53 241.11 397.64 122.37 278.58 324.29 PLACE1006598 0.72 8.53 2.4 1.53 1.58 2.07 PLACE1006607 1.47 7.69 4.18 3.45 5.86 4.29 PLACE1006610 9.46 13.73 38.26 27.65 32.76 22.64 PLACE1006615 6.22 9.09 18.78 20.25 15.74 15.86 PLACE1006617 0.91 1.54 2.66 1.87 2.49 2.09 PLACE1006618 5.42 8.01 9.24 5.33 8.59 5.76 PLACE1006626 1.53 4.11 1.3 2.47 2.78 1.16 PLACE1006629 0.99 5.05 1.36 2.22 2.56 1.76 PLACE1006637 1.29 6.54 3.97 3.77 4.23 4.87 PLACE1006640 0.59 5.14 1.17 0.85 2.54 0.94 PLACE1006644 1.66 4.46 2.12 2.79 2.49 2.39 PLACE1006657 1.28 2.09 2.31 4.55 3.09 2.19 PLACE1006673 2.29 4.73 10.34 11.06 10.89 6.45 PLACE1006678 2.54 2.98 1.44 1.37 1.96 1.39 PLACE1006682 3.5 5.93 2.58 15.44 20.96 23.99 ** + PLACE1006684 1.12 4.8 1.81 1.64 2.54 1.65 PLACE1006698 1.54 5.86 4.52 2.15 3.57 1.9 PLACE1006704 1.81 5.41 2.71 2.93 2.92 2.97 PLACE1006708 1.69 5.07 3.49 3.46 4.11 3.7 PLACE1006711 14.21 16.18 29.77 24.34 26.25 22.42 PLACE1006714 2.27 3.26 4.74 4.57 5.23 3.53 PLACE1006716 1.51 2.75 3.7 6 7.05 3.99 PLACE1006731 1.65 3.77 2.83 2.71 4 3.09 PLACE1006754 0.43 3.94 1.73 1.8 1.81 0.99 PLACE1006760 7.56 10.98 10.08 8.58 8.89 11.31 PLACE1006779 1.44 4.12 2.88 3.19 3.79 2.97 PLACE1006782 0.44 5.17 2.42 2.95 1.57 1.15 PLACE1006783 9.34 11.46 18.65 157.98 223.05 66.46 * + PLACE1006786 3.31 4.08 6.07 5.9 6.24 3.34 PLACE1006792 1.61 3.31 5.38 5.66 3.33 4.18 PLACE1006795 0.89 2.43 0.74 0.81 1.27 1.01 PLACE1006800 1.62 4.94 2.53 4.7 4.56 3.93 PLACE1006805 3.94 7.79 5.5 10.83 9.8 8.79 * + PLACE1006809 3.55 5.7 5.94 9.58 10.61 8.97 ** + PLACE1006815 1.7 7.57 4.1 5.12 5.23 5.8 PLACE1006819 0.33 0.88 0.95 0.89 1.76 0.63 PLACE1006820 2.35 2.01 4.91 4.84 6.72 4.18 PLACE1006826 2.28 6.22 4.84 7.68 7.62 5.58 PLACE1006829 3.76 5.51 6.54 9.49 8.66 8.69 * + PLACE1006853 1.2 4.21 1.97 2.25 2.93 2.88 PLACE1006860 1 4.29 1.62 1.61 2.1 1 PLACE1006867 5.65 9.36 11.34 7.04 8.33 7.63 PLACE1006875 1.15 6.19 5.66 4.84 4.53 4.63 PLACE1006878 1.59 2.84 3.09 2.99 3.22 2.39 PLACE1006883 3.21 5.08 6.78 6.83 7.38 6.19 PLACE1006898 1.67 4.23 3.67 3.54 4.77 4.59 PLACE1006901 2.59 4.75 4.03 3.71 3.28 4.14 PLACE1006904 0.91 3.59 2.7 3.26 2.92 2.04 PLACE1006917 3.63 7.13 6.1 5.8 7.21 7.03 PLACE1006932 0.54 5.85 1.29 0.92 1.34 1.19 PLACE1006935 1.3 5.46 2.54 1.59 4.03 1.6 PLACE1006956 0.92 2.55 3.4 2.55 2.41 2.09 PLACE1006958 0.78 2.41 1.35 1.76 4.2 3.39 PLACE1006959 4.97 8.48 9.98 11.46 9.58 13.62 PLACE1006961 8.03 9.85 14.42 13.73 11.57 14.2 PLACE1006962 2.97 7.44 6.56 5.04 7.26 6.22 PLACE1006966 2.02 6.94 3.46 3.15 3.89 2.89 PLACE1006979 0.95 4.44 2.03 1.46 2.64 1.77 PLACE1006989 2.19 5.05 3.02 3.27 3.9 5.06 PLACE1007001 4.98 6.79 10.71 4.03 7.43 7.38 PLACE1007014 1.37 3.03 3.45 1.79 2.18 2.2 PLACE1007021 0.74 3.03 2.11 0.75 2.2 1.73 PLACE1007026 2.1 9.23 3.93 4.15 4.27 5.42 PLACE1007028 4.12 8.5 10.56 7.89 8.34 9.35 PLACE1007038 237.33 267.91 446.14 406.27 622.67 671.17 PLACE1007040 1.55 3.14 2.85 1.57 3.31 2.45 PLACE1007045 1.08 3.74 2.85 2.9 5.03 2.74 PLACE1007048 147.06 149.67 259.53 121.61 211.26 109.43 PLACE1007053 4.9 6.69 10 3.59 4.91 4.71 PLACE1007068 7.56 10.33 62.76 39.52 45.9 36.69 PLACE1007070 5.97 10.85 10.28 8.65 9.6 14.3 PLACE1007076 8.22 14.4 14.19 16.53 23.62 24.67 * + PLACE1007077 2.65 6.45 4.01 5.2 5.28 5.43 PLACE1007081 0.36 4.47 1.94 1.92 1.92 1.37 PLACE1007082 1.23 4.66 4.95 4.32 4.5 3.99 PLACE1007092 2.49 4.12 7.26 4.77 5.22 4.34 PLACE1007096 0.72 2.19 0.74 1.35 1.63 0.97 PLACE1007097 0.54 2.49 1.35 1.61 1.28 1.04 PLACE1007099 1.58 4.66 2.56 2.77 3.64 3.72 PLACE1007105 1.18 6.51 3.44 2.65 4.13 2.21 PLACE1007108 3.55 13.02 7.41 5.03 6.87 5.75 PLACE1007111 1.33 9.51 1.52 1.74 2.37 1.52 PLACE1007112 1.23 7.26 1.79 2.09 3.12 2.36 PLACE1007130 0.54 2.02 1.92 0.87 1.47 0.33 PLACE1007132 1.46 3.32 4.63 3.58 3.38 2.88 PLACE1007140 0.61 2.58 2.41 1.98 1.98 1.32 PLACE1007143 2.79 6.32 4.62 4.9 5.34 5.33 PLACE1007169 2.21 8.59 3.46 5.44 8.46 7.99 PLACE1007178 0.82 8.66 2.48 3.28 6.28 4.1 PLACE1007190 3.31 10.9 6.7 10.51 13.57 11.14 PLACE1007201 0.81 5.82 1.41 1.72 3.04 2.51 PLACE1007202 37.76 34.95 76.28 58.23 34.42 37.86 PLACE1007226 2.01 2.39 2.73 1.89 3.14 2.29 PLACE1007238 1.64 3.07 1.83 2.39 2.73 2.2 PLACE1007239 1.81 3.68 2.99 1.76 2.72 2.44 PLACE1007242 0.61 5.18 1.87 1.54 1.14 1.67 PLACE1007243 2.21 7.36 2.29 2.24 3.27 3.31 PLACE1007247 0.36 6.17 1.71 1.11 1.36 1.34 PLACE1007257 1.67 5.33 3.34 3.3 5.27 4.25 PLACE1007274 1.46 2.18 4.43 4.38 4.03 4.06 PLACE1007276 0.93 2.02 1.1 2.13 2.1 1.74 PLACE1007282 2.51 4.2 5.72 4.28 3.62 4.66 PLACE1007286 2.97 4.8 7.85 10.14 12.47 8.79 * + PLACE1007296 10.55 19.45 24.46 31.43 17.57 27.05 PLACE1007301 0.65 5.17 1.55 1.19 1.54 1.11 PLACE1007314 3.11 6.61 8.64 7.98 8.96 10.24 PLACE1007317 1.19 3.34 1.27 1.88 1.62 1.79 PLACE1007329 0.89 0.73 1.78 2.38 2.35 2.09 * + PLACE1007338 3.96 6.47 9.58 11.59 8.93 2.32 PLACE1007342 0.71 1.8 1.3 1.1 1.1 0.7 PLACE1007345 1.72 4.57 2.54 2.72 3.6 3.29 PLACE1007346 1.43 4.61 3.89 5.77 4.53 4.1 PLACE1007359 0.74 4.55 2.16 2.59 2.44 3.53 PLACE1007367 4.53 8.63 15.16 12.49 13.49 11.75 PLACE1007375 0.36 3.24 2.02 1.75 2.56 1.59 PLACE1007377 1.49 2.01 3.18 3.29 3.96 2.36 PLACE1007386 1.55 1.75 1.47 2.37 1.68 1.36 PLACE1007392 1.57 2.99 2.49 2.79 4.48 3.51 PLACE1007402 2.41 5.66 3.08 1.52 2.91 1.8 PLACE1007409 1.05 4.57 1.04 2.51 2.68 2.02 PLACE1007416 3.45 6.97 6.5 7.05 9.14 6.52 PLACE1007420 12.12 12.66 20.8 25.26 23.9 22.88 * + PLACE1007431 1.87 7.4 5.51 7.17 5.28 5.91 PLACE1007450 0.79 1.22 2.65 3 2.99 2.39 PLACE1007452 0.42 2.36 1.76 2.09 2.98 1.45 PLACE1007454 23.74 28.02 76.56 59.97 75.95 46.61 PLACE1007460 0.75 3.52 2.35 2.34 1.93 2.58 PLACE1007478 0.41 3.07 1.33 1.35 2.18 1.92 PLACE1007484 0.6 4.8 2.57 2.56 1.45 1.69 PLACE1007488 0.4 6.24 1.64 1.74 2.61 1.46 PLACE1007507 2.91 6.36 4.49 5.31 8.29 8.11 PLACE1007511 0.53 1.29 1.06 1.06 1.29 0.42 PLACE1007513 10.57 10.43 24.05 12.24 16.88 16.9 PLACE1007524 1.55 3.33 3.53 3.96 4.72 2.96 PLACE1007525 1.24 2.95 3.14 2.38 2.85 2.24 PLACE1007537 8.6 9.68 49.88 43.78 63.66 40.1 PLACE1007544 1.55 6.45 4.97 3.2 3.92 4.61 PLACE1007547 1.36 5.03 4.15 2.37 2.84 2.4 PLACE1007557 1.12 3.16 3.14 3.07 3.9 3.41 PLACE1007560 9.38 8.86 12.57 11.03 9.62 17.59 PLACE1007565 0.37 2.27 1 1 1.16 0.91 PLACE1007580 1.06 3.71 3.06 10.8 11.15 13.74 ** + PLACE1007583 0.76 3.88 1.78 2.51 2.37 1.09 PLACE1007591 0.79 4.62 1.7 2.2 2.53 2.07 PLACE1007598 1.13 6.98 3.86 2.71 3.46 4.71 PLACE1007610 0.41 5.63 1.28 1.33 3.18 1.5 PLACE1007618 1.57 1.91 2.01 1.75 2.2 2.41 PLACE1007621 1.78 2.83 3.64 3.33 3.57 4.38 PLACE1007626 23.99 25.61 32.78 30.53 30.94 13.53 PLACE1007632 2.03 3.26 2.52 2.65 3.81 4.63 PLACE1007635 1.61 4.62 6.42 2.8 4.19 3.37 PLACE1007645 10.59 11.55 15.06 9.99 11.58 11.95 PLACE1007649 1.7 5.88 3.47 2.78 4.95 3.13 PLACE1007659 1.33 5.85 3.61 4.88 6.22 4.9 PLACE1007669 2.01 2.1 3.74 2.97 4.63 4.4 PLACE1007677 1.25 2.29 2.81 2.68 3.07 2.91 PLACE1007688 3.4 5.69 5.43 1.98 4.53 4.98 PLACE1007690 1.4 4.03 2.12 3.74 3.37 4.61 PLACE1007697 0.69 7.13 1.37 1.84 2.56 1.8 PLACE1007702 2.03 7.08 5.7 4.03 3.91 4.08 PLACE1007705 1.38 3.93 1.59 1.74 4.45 2.75 PLACE1007706 3.11 6.08 4.69 5.25 8.84 7.49 PLACE1007725 3.41 4.69 6.65 5.1 3.29 5.39 PLACE1007729 0.98 2.65 1.8 2.7 3.11 1.99 PLACE1007730 1.25 4.29 3.07 3.66 3.75 4.32 PLACE1007737 1.43 4.79 3.39 3.79 4.7 4.17 PLACE1007743 1.38 4.26 2.29 2.3 2.83 2.03 PLACE1007746 6.56 9.02 10.42 9.65 13.29 12.97 PLACE1007753 0.53 4.48 1.71 1.35 2.86 1.94 PLACE1007769 1.31 4.31 3.5 3.27 4.51 4.58 PLACE1007780 5.77 4.63 7.11 6.51 3.75 2.17 PLACE1007791 1.82 3.29 3.38 3.16 3.69 2.87 PLACE1007807 0.67 2.79 1.72 2.33 1.76 1.29 PLACE1007810 0.39 4.45 2.63 4.11 4.08 3.27 PLACE1007814 3.57 5.98 5.04 4.2 4.62 6.3 PLACE1007828 2.01 7.64 3.34 2.69 4.64 3.44 PLACE1007829 1.32 6.9 2.88 2.87 4.87 3.06 PLACE1007841 1.64 7.26 1.87 2.25 3.14 3.39 PLACE1007842 1.1 3.32 2.44 2.09 3.96 1.39 PLACE1007843 1.2 1.92 1.43 2.13 1.48 1.86 PLACE1007845 1.76 3 4.11 3.45 3.42 2.36 PLACE1007846 0.99 3.26 1.64 2.02 2.73 1.5 PLACE1007848 1.09 3.51 2.23 2.39 2.62 2.25 PLACE1007852 2.26 7.88 3.82 2.94 4.61 3.24 PLACE1007858 3.65 11.57 5.81 61.71 80.46 57.09 ** + PLACE1007866 19.42 25.98 40.48 43 80.39 56.73 PLACE1007871 8.1 7.9 15.45 16.17 12.35 11.08 PLACE1007877 1.09 2.09 1.45 1.4 2.39 1.53 PLACE1007878 5.98 9.75 14.61 13.65 7.49 8.9 PLACE1007881 0.43 2.66 1.34 1.59 1.94 1.93 PLACE1007885 4.35 7.85 6.76 5.57 6.53 7.01 PLACE1007897 0.27 6.51 1.85 1.72 1.53 1.41 PLACE1007908 3.14 12.29 5.73 5.96 7.9 8.24 PLACE1007922 6.08 11.75 8.75 5.24 7.15 4.54 PLACE1007946 1.07 2.03 1.86 2.71 2.28 1.94 PLACE1007950 6.98 7.6 18.21 16.17 19.34 12.63 PLACE1007954 -0.03 2.45 1.15 2.46 1.57 1.51 PLACE1007955 0.92 4.01 2.17 2.05 2.52 3.05 PLACE1007956 0.6 3.61 2.91 2.35 2.1 2.22 PLACE1007958 0.75 6.31 1.34 0.79 1.21 0.8 PLACE1007965 0.64 5.88 3.25 3.38 2.91 2.17 PLACE1007969 1.09 6.37 3.06 2.35 3.29 2.21 PLACE1007971 2.73 4.17 5.21 6.1 4.41 5.92 PLACE1007990 1.95 2.33 2.31 3.22 3.09 1.88 PLACE1008000 0.32 2.16 1.98 1.85 1.27 0.66 PLACE1008002 0.99 3.38 1.7 1.81 2.04 0.51 PLACE1008037 0.57 4.19 1.7 4.59 2.86 2.02 PLACE1008044 1.42 5.81 2.46 4.18 4.93 4.16 PLACE1008045 0.4 4.07 1.54 1.75 2 1.65 PLACE1008080 2.05 6.08 3.22 4.23 4.03 4.78 PLACE1008092 1.56 1.56 1.48 1.48 2.98 1.86 PLACE1008095 0.59 2.14 1.48 2.38 2.73 1.23 PLACE1008105 0.95 1.76 1.71 2.24 2.71 0.74 PLACE1008107 0.27 2.33 0.7 1.72 1.44 1.68 PLACE1008111 1.73 5.01 2.12 4.57 5.4 4.04 PLACE1008113 5.88 9.24 12.48 16.57 20.29 19.24 * + PLACE1008122 1.22 5.54 2.55 1.61 1.57 1.5 PLACE1008129 1.5 5.64 2.8 2.43 5.36 2.91 PLACE1008132 5.51 4.47 8.34 6.61 11.2 7.63 PLACE1008137 0.96 1.82 1.02 2.12 3.88 0.8 PLACE1008174 0.77 3.16 2.43 5.12 4.39 2.46 PLACE1008177 1.62 4.87 3.09 3.79 3.26 3.77 PLACE1008181 1.76 3.87 1.6 2.06 2.43 1.43 PLACE1008195 2.66 6.08 2.97 4.34 4.14 3.9 PLACE1008198 1.06 5.56 2.52 2.55 3.31 1.54 PLACE1008201 1.22 4.45 3.58 5.92 7.69 5.64 * + PLACE1008209 2.35 2.29 4.46 2.51 5.31 4.44 PLACE1008226 1.8 2.35 5.25 4.72 5.68 7.08 PLACE1008227 0.77 2.67 3.02 2.38 4.6 3.54 PLACE1008231 1.26 3.85 1.85 1.05 1.83 0.78 PLACE1008238 1.22 3.21 2.9 2.47 2 1.72 PLACE1008244 1.01 4.69 1.56 1.68 3.2 1.56 PLACE1008249 0.8 4.94 2.55 1.22 2.17 2.01 PLACE1008266 11.31 18.61 43.04 60.04 82.48 59.04 * + PLACE1008273 1.47 3.95 3.81 3.53 3.8 4.47 PLACE1008275 1.59 3.67 2.17 2.62 2.57 2.34 PLACE1008280 0.85 2.6 1.84 2.42 2.48 2.36 PLACE1008282 4.71 8.19 6.89 7.27 9.02 6.38 PLACE1008297 2.32 4.7 3.36 2.89 3.42 3.21 PLACE1008303 1.65 6.68 1.24 4.12 3.83 2.65 PLACE1008309 0.43 6.52 0.82 1.77 1.5 1.29 PLACE1008315 5.3 5.93 8.61 4.92 4.79 9.83 PLACE1008329 0.47 2.23 2.06 2.32 2.8 2.49 PLACE1008330 0.72 4.06 3.16 2.48 3.36 2.96 PLACE1008331 0.84 5.01 2.1 4.5 2.17 2.91 PLACE1008351 4.34 8.66 7.41 7.91 7.31 7.1 PLACE1008356 1.56 8.23 1.93 2.86 4.16 3.35 PLACE1008359 1.57 4.11 2.89 2 2.97 2.94 PLACE1008368 2.27 6.38 7.43 5.72 7.33 6.95 PLACE1008369 0.57 2.46 1.45 1.12 1.59 1.68 PLACE1008392 0.8 3.09 2.54 2.44 3.22 3.24 PLACE1008394 2.08 4.84 3.75 3.98 5.03 4.76 PLACE1008398 5.32 9.36 11.44 11.36 11.3 12.33 PLACE1008401 1.19 7.06 3.21 2.82 3.43 3.33 PLACE1008402 3.21 6.45 7.2 7.23 10.15 9.26 PLACE1008405 10.3 10.95 18.42 17.17 18.82 20.4 PLACE1008409 1.88 5.19 5.69 4.97 5.41 5.65 PLACE1008420 1.4 1.87 1.96 2.67 2.69 2.27 * + PLACE1008424 0.88 2.69 2.54 1.69 2.34 1.71 PLACE1008426 0.98 2.58 1.58 1.7 2.66 2.32 PLACE1008429 0.92 3.17 2.14 1.91 3.4 1.84 PLACE1008430 1.63 4.85 3.04 2.93 3.52 3 PLACE1008437 0.87 3.64 3.01 2.83 1.82 1.57 PLACE1008453 1.16 4.8 1.02 1.64 2.06 1.17 PLACE1008454 2.14 6.46 9.23 5.46 9.02 5.92 PLACE1008455 2.06 4.33 7.2 5.26 6.68 4.87 PLACE1008457 0.51 2.6 2.01 2.28 2.43 2.47 PLACE1008465 0.49 2.41 1.72 1.56 2.13 0.48 PLACE1008469 2.42 4.36 5.32 5.16 4.75 7.1 PLACE1008488 0.81 5.48 1.97 2.44 2.03 1.8 PLACE1008519 1.48 10.85 6.17 4.41 4.99 4.51 PLACE1008524 1.04 11.09 1.72 2 3.22 2.02 PLACE1008531 0.64 8.37 1.92 1.33 2.05 1.72 PLACE1008532 2.12 3 5.51 5.66 4.72 4.19 PLACE1008533 2.01 4 4.07 5.53 5.18 3.77 PLACE1008542 1.61 2.36 0.96 2.05 2.1 1.72 PLACE1008549 0.96 3.06 0.67 1.45 2.1 1.53 PLACE1008560 1.18 4.23 2.28 2.29 3.93 3.47 PLACE1008567 0.87 7.26 1.85 2.33 3.67 2.38 PLACE1008568 2.37 10.67 5.49 2.97 7.47 4.21 PLACE1008569 3.94 10.32 6.74 6.1 8.6 7.6 PLACE1008584 0.88 1.4 1.58 2.86 3.38 1.31 PLACE1008585 4.96 4.8 7.56 11.08 4.84 3.57 PLACE1008603 5.9 7.25 31 30.55 43.67 29.76 PLACE1008621 0.55 2.28 0.95 0.72 1.89 1.16 PLACE1008625 0.64 4.01 0.9 1.18 1.41 2.03 PLACE1008626 0.55 6.06 0.9 1.03 0.83 0.95 PLACE1008627 0.46 8.32 1.86 1.87 3.34 2.7 PLACE1008629 3.22 9.18 5.84 5.44 6.75 4.41 PLACE1008630 1.68 3.39 4.23 4.21 3.01 3.51 PLACE1008643 1.31 0.93 1.98 1.72 2.34 1.94 PLACE1008650 0.25 3.05 1.62 2.23 1.63 1.24 PLACE1008657 1.17 2.39 2.51 2.34 4.04 2.91 PLACE1008664 0.91 5.93 2.37 2.91 2.51 1.13 PLACE1008693 0.97 4.93 3.09 2.53 3.81 2.2 PLACE1008696 0.88 3.84 2.21 2.26 2.11 1.47 PLACE1008715 1.05 4.71 2.11 1.34 2.65 2.65 PLACE1008716 2.48 3.94 4.19 5.75 6.9 7.07 * + PLACE1008722 3.85 4.34 7.37 7.64 7.19 3.45 PLACE1008738 5.17 9.13 12.7 9.49 5.83 4.8 PLACE1008742 6.57 6.87 14.66 14.94 15.06 12.41 PLACE1008744 3.52 6.98 5.61 5.83 4.55 2.74 PLACE1008748 0.63 4.39 2.75 2.44 1.67 1.61 PLACE1008757 0.99 4.74 4.51 2.77 5.74 2.17 PLACE1008766 2.66 6.75 3.77 3.51 6.47 4.06 PLACE1008785 1.39 1.68 2.6 3.26 3.8 3.89 * + PLACE1008790 1.57 1.8 2.29 3.5 5.39 2.96 PLACE1008798 1.71 3.82 4.45 6 5.93 3.32 PLACE1008807 1.34 3.95 1.61 2.54 2.62 1.8 PLACE1008808 1.6 4.53 3.01 4.24 3.69 5.04 PLACE1008813 1.38 4.85 1.97 1.9 1.95 2.3 PLACE1008836 1.34 5.81 3.68 3.89 6.17 4.1 PLACE1008851 1.21 6.65 3.94 4.85 10.04 4.54 PLACE1008854 0.56 0.48 1.14 1.16 1.41 1.6 PLACE1008864 1.98 1.92 2.96 2.73 2.65 2.49 PLACE1008867 1.2 6.57 6.22 6.43 5.71 4.82 PLACE1008876 11.7 16.5 27.29 26.74 20.94 23.24 PLACE1008887 1.37 4.31 1.44 3.26 2.07 3.28 PLACE1008902 1.33 5.62 2.93 3.17 4.58 2.06 PLACE1008911 4.04 8.56 10.48 11.31 13.99 15.66 PLACE1008917 0.6 4.53 2.72 1.7 2.9 1.71 PLACE1008920 0.75 0.77 0.87 0.61 1.58 1.44 PLACE1008925 0.25 0.9 1.04 0.94 1.91 0.84 PLACE1008930 4.12 7.32 9.83 5.11 10.36 7.17 PLACE1008934 0.9 3.42 2.9 2.89 2.28 1.7 PLACE1008941 1.57 4.14 2.8 2.06 2.59 4.05 PLACE1008947 2.3 5.41 5.51 3.96 5.84 5.16 PLACE1008984 1.26 6.31 3.25 3.1 3.93 3.19 PLACE1008985 0.94 2.75 2.74 2.84 2.43 2.7 PLACE1008994 0.27 1.72 0.65 1.11 0.78 0.68 PLACE1009020 0.46 3.49 2.42 2.49 3.1 2.16 PLACE1009027 0.89 2.7 1.59 2.24 1.75 2.09 PLACE1009039 -0.06 3.31 3.42 2.39 1.59 1.49 PLACE1009045 1.53 6.33 6.05 23.13 20.76 22.2 ** + PLACE1009048 0.41 5.97 2.3 0.61 1.04 0.54 PLACE1009050 0.97 4.9 1.68 1.07 1.47 1.55 PLACE1009060 5.61 8.4 9.51 10.74 8.55 11.96 PLACE1009067 1.14 2.8 2.03 1.6 2.34 3.4 PLACE1009071 1.44 4.05 3.9 3.79 7.24 9.82 PLACE1009090 1.27 6.46 2.35 3.11 4.73 2.86 PLACE1009091 5.58 10.22 38.11 38.77 49.35 36.29 PLACE1009094 0.26 5.68 1.88 1.67 5.04 1.71 PLACE1009099 1 5.52 3.47 3.49 3.36 3.84 PLACE1009110 1.59 5.82 1.16 1.68 4.3 4.39 PLACE1009111 1.88 5.24 2.65 3.95 3.77 2.88 PLACE1009113 2.24 3.52 3.62 6.14 4.87 7.29 * + PLACE1009130 4.46 6.8 7.84 6.68 9.36 10.47 PLACE1009150 0.88 3.54 1.95 3.23 3.3 3.01 PLACE1009155 1.11 5.06 2.98 4.46 4.43 3.87 PLACE1009158 1.06 5.77 1.95 1.77 2.35 2.88 PLACE1009166 0.76 4.8 1.53 1.59 2.16 1.3 PLACE1009172 1.43 3.96 2.45 2.26 5.85 2.61 PLACE1009174 1.13 3.45 2.42 1.67 3.02 2.38 PLACE1009183 1.62 3.54 4.47 4.1 6.33 8.06 PLACE1009186 1.04 5.07 2.3 2.46 2.86 2.91 PLACE1009190 0.75 2.32 1.44 1.53 1.9 1.65 PLACE1009196 0.81 4.01 2.73 2.24 2.38 1.99 PLACE1009200 1.01 4.44 2.94 2.84 4.39 2.91 PLACE1009217 2.55 4.91 3.43 4.46 7.29 7.23 PLACE1009230 1.9 5.55 6.63 5.63 9.16 9.46 PLACE1009236 4.97 7.07 12.6 8.21 10.79 7.13 PLACE1009246 11.71 11.96 24.75 14.59 16.36 9.05 PLACE1009265 6.95 7.82 14.01 15.61 5.19 12.17 PLACE1009279 0.67 2.07 2.46 1.93 2.54 1.63 PLACE1009298 5.54 9.92 9.52 10.21 11.25 17.55 PLACE1009308 1.13 6.82 2.04 2.48 2.48 2.34 PLACE1009319 2.04 9.25 3.15 2.92 3.54 2.5 PLACE1009328 1.04 5.78 1.81 2.98 3.39 2.17 PLACE1009335 1.38 6.55 4.72 2.24 3.21 3.01 PLACE1009338 2.56 4.14 5.1 3.24 4.3 1.57 PLACE1009344 0.73 2.45 1.08 1.31 1.55 0.84 PLACE1009355 5.41 7.37 9.95 13.44 10.76 13.55 * + PLACE1009368 1.3 2.56 2.41 2.43 2.32 2.19 PLACE1009375 1.21 6.41 3.05 3.04 4.46 2.53 PLACE1009388 1.18 8.68 3.01 3.46 4.53 2.72 PLACE1009398 1.19 9.2 3.74 3.17 4.28 3.96 PLACE1009404 2.78 9.18 4.51 5.33 6.73 6.94 PLACE1009410 1.27 2.35 2.33 2.51 2.31 1.44 PLACE1009417 0.95 2.25 4.34 2.55 3.08 1.71 PLACE1009424 1.88 3.61 3.18 2.85 3.24 3.93 PLACE1009434 0.84 3.94 2.91 1.29 1.82 2.19 PLACE1009443 1.21 7.2 2.55 2.42 3.43 3.17 PLACE1009444 1.33 7.71 4.05 2.51 3.17 3.79 PLACE1009459 0.23 7.99 1.55 1.71 1.83 0.86 PLACE1009460 1.75 6.84 3.26 5.15 4.31 4.08 PLACE1009468 0.99 2.83 3.42 4.43 4.42 2.97 PLACE1009476 0.21 1.21 0.73 1.05 0.67 1.33 PLACE1009477 1.35 3.13 2.67 3.06 2.35 2.2 PLACE1009493 0.87 3.35 0.94 1 1.87 1.41 PLACE1009502 0.76 4.64 2.13 1.19 1.89 1.66 PLACE1009524 1.32 4.22 1.63 0.94 2.14 1.6 PLACE1009527 0.95 4.51 2.11 1.64 2.55 1.28 PLACE1009531 20.82 28.24 41.52 46.25 43.25 49.96 PLACE1009535 1.1 1.56 2.68 2.42 2.15 1.11 PLACE1009539 2.15 3.41 4.18 3.88 2.65 2.57 PLACE1009540 5.89 8 11.66 14.8 4.47 3.84 PLACE1009542 1.11 3.37 1.42 1.51 2.06 1.44 PLACE1009546 0.62 5.27 0.97 2.24 1.64 1.25 PLACE1009556 0.35 4.46 3.46 3.36 2.86 3.16 PLACE1009569 0.05 3.93 2.46 3.34 2.7 3.11 PLACE1009571 1.67 4.27 2.52 3.04 2.85 2.67 PLACE1009573 3.81 2.97 6.73 6.92 8.12 6.49 PLACE1009576 1.92 2.51 4.3 2.73 3.66 2.08 PLACE1009580 1.42 1.81 1.74 2.73 3.47 2.33 * + PLACE1009581 0.89 4.25 2.03 2.91 4.38 2.74 PLACE1009587 0.96 4.91 2.29 2.43 3.2 1.99 PLACE1009593 2.71 6.73 4.37 4.94 6.85 5.03 PLACE1009595 1.81 5.44 2.66 2.67 5 2.79 PLACE1009596 1.57 6.83 2.6 3.44 3.97 2.7 PLACE1009600 3.03 4.27 4.48 5.48 9.14 4.42 PLACE1009604 2.32 4.64 5.02 4.22 6.11 3.23 PLACE1009607 1.29 2.48 3.18 3.19 4.17 3.18 PLACE1009613 1.94 5.23 2.94 2.65 3.08 2.23 PLACE1009621 1.66 6.72 3.32 8.21 8.67 8.06 * + PLACE1009622 1.78 5.93 3.78 3.9 4.1 3.9 PLACE1009624 1.16 5.77 3.42 3.2 3.65 3.5 PLACE1009637 2 6.88 3.36 3.07 4.59 3.91 PLACE1009639 1.94 1.76 4.15 3.44 3.67 4.99 PLACE1009654 20.88 17.13 34.95 14.94 24.53 20.64 PLACE1009659 2.77 6.78 7.45 6.38 8.38 6.55 PLACE1009665 1.04 4.21 1.93 1.19 2.72 1.93 PLACE1009669 7.73 9.64 14.54 9.85 16.89 8.82 PLACE1009670 1.76 5.36 2.54 2.77 4.47 4.01 PLACE1009708 2.1 5.57 5.09 3.64 6.54 5.84 PLACE1009721 1.34 4.28 3.56 5.78 5.81 3.01 PLACE1009731 1.36 3.59 3 3.58 6.53 5 PLACE1009735 1.94 3.94 3.21 5.16 7.52 4.78 PLACE1009737 1.89 4.29 2.95 4.83 5.61 5.47 * + PLACE1009741 1.3 4.32 3.45 2.09 5.03 3.07 PLACE1009752 1.34 5.64 2.65 2.3 3.33 1.68 PLACE1009763 3.95 9.73 6.82 7.13 7.44 8.39 PLACE1009766 1.46 6.98 3.32 3.07 5.19 3.75 PLACE1009772 0.48 5.19 0.6 1.01 2.46 0.89 PLACE1009782 0.91 2.39 2.03 2.88 2.91 3.74 PLACE1009794 2.58 4.45 5.11 3.54 3.66 5.03 PLACE1009798 1.59 5.37 4 6.26 5.57 5.67 PLACE1009845 1.05 6.02 2.92 2.79 3.39 3.92 PLACE1009849 0.96 6.61 2.35 1.79 3.41 2.59 PLACE1009857 0.79 4.86 1.45 1.19 1.27 1.56 PLACE1009861 1.43 4.67 3.87 4.1 3.47 3.11 PLACE1009872 53.53 52.43 88.5 74.95 49.47 81.73 PLACE1009877 5.45 7.59 12.08 10.03 10.3 12.32 PLACE1009879 0.82 3.28 1.59 1.55 2.99 1.34 PLACE1009886 0.68 4.04 1.53 1.62 3.04 1.72 PLACE1009888 1.03 7.4 3.23 5.34 5.84 7.94 PLACE1009908 1.56 7.63 8.64 3.37 6.71 5.9 PLACE1009919 4.5 7.53 8.26 5.84 10.72 10.15 PLACE1009921 0.96 3.94 3.32 1.63 4.28 2.47 PLACE1009923 3.82 5.56 6.85 6.32 8.13 5.57 PLACE1009924 3.01 2.49 4.53 4.43 4.31 1.04 PLACE1009925 0.61 2.77 1.84 2.51 2.2 2.5 PLACE1009931 2.78 5.21 9 8.71 6.93 8.09 PLACE1009935 0.74 3.71 2.1 1.19 1.08 1.5 PLACE1009947 0.47 3.83 1.64 1.51 2.46 2.03 PLACE1009961 0.43 4.08 1.39 1.69 2.18 1.9 PLACE1009971 0.92 4.9 1.98 1.35 1.74 1.45 PLACE1009982 40.34 48.71 89.8 53.8 57.87 66.96 PLACE1009992 0.94 1.9 2.59 1.47 2.52 0.68 PLACE1009995 6.47 10.83 15.72 7.79 9.03 11.23 PLACE1009997 0.55 3.7 3.03 2.76 3.2 2.64 PLACE1010002 1.4 4.14 2.82 2.89 3.04 3.46 PLACE1010011 2.09 8.13 3.85 4.4 5.21 4.68 PLACE1010013 0.18 12.85 1.74 0.92 1.81 0.68 PLACE1010021 3.18 11.98 5.42 4.12 4.13 6.06 PLACE1010023 2.15 8.45 5.16 5.62 6.52 6.14 PLACE1010031 4.6 4.35 7.23 6.79 4.91 1.82 PLACE1010039 1.17 3.3 1.45 1.28 1.23 1.19 PLACE1010045 1.1 2.83 3.66 2.52 3.55 2.64 PLACE1010053 1.42 3.56 1.65 2.21 2.76 2.37 PLACE1010060 1.63 6.1 4.13 4.11 4.6 4.05 PLACE1010069 0.41 7.96 2.32 1.48 2.91 1.3 PLACE1010070 0.92 8.04 1.5 0.45 1.78 1.09 PLACE1010074 5.25 11.67 11.8 12.32 9.51 11.22 PLACE1010076 12.75 11.95 29.01 19.58 15.88 16.82 PLACE1010078 2.96 2.42 4.36 4.64 4.39 3.85 PLACE1010081 2.74 4.1 3.7 6.85 7.81 4.59 * + PLACE1010083 0.69 2.53 1.51 1.22 1.86 2.26 PLACE1010089 1.86 4.89 3.35 3.45 3.47 3.48 PLACE1010096 2.17 7.73 2.91 3.43 4.19 3.2 PLACE1010102 3.89 10.9 5.33 7.1 9.64 7.57 PLACE1010105 2.98 7.46 4.93 7.31 9.04 9.82 PLACE1010106 2.46 2.95 4.48 5.47 4.88 5.8 * + PLACE1010130 0.53 1.79 1.17 2.27 2.55 1.23 PLACE1010132 2.49 4.65 5.3 5.07 4.39 4.19 PLACE1010134 0.8 3.32 1.15 1.97 2.31 1.67 PLACE1010139 6.67 10.51 12.98 14.99 16.1 14.58 PLACE1010148 0.96 5.07 1.62 1.48 1.9 1.97 PLACE1010152 3.11 5.68 5.16 6.33 6.64 5.76 PLACE1010155 3.8 6.17 6.52 16.85 20.56 20.32 ** + PLACE1010156 13.71 15.43 32.21 132.45 85.59 134.99 ** + PLACE1010161 1.9 2.81 5.05 3.29 2.92 1.97 PLACE1010181 0.73 2.22 1.51 2.58 1.99 2.53 PLACE1010194 0.64 3.35 1.03 2.26 2.14 1.64 PLACE1010202 0.4 4.14 1.2 2.91 1.65 2.16 PLACE1010231 1.1 3.78 2.39 1.31 2.99 2.73 PLACE1010235 1.26 4.24 1.94 2.68 2.42 3.16 PLACE1010237 1.01 3.4 2.1 1.14 1.97 0.87 PLACE1010251 0.59 0.98 1.95 2.57 3.18 1.62 PLACE1010261 0.97 2.63 2.07 2.69 1.69 1.55 PLACE1010270 0.76 2.7 1.3 1.39 2.33 1.42 PLACE1010273 0.97 3.27 0.46 1.48 2.25 1.5 PLACE1010274 6.28 9.23 9.66 10.49 12.18 14.28 PLACE1010277 6.03 10.14 12.68 14.6 16.06 15.84 * + PLACE1010293 1.8 5.68 3.55 3.65 3.37 3.96 PLACE1010297 5.17 11.37 21 24.84 32.59 22.06 PLACE1010300 4.18 4.78 8.22 8 9.95 6.87 PLACE1010310 16.52 14.75 49.45 70.74 71 77.01 * + PLACE1010321 2.03 4.92 2.46 3.37 4.99 2.73 PLACE1010324 0.88 3.49 1.56 1.12 1.54 1.2 PLACE1010329 0.73 4.64 1.95 2.56 3.37 1.96 PLACE1010330 3.78 9.09 7.29 2.42 10.45 7.67 PLACE1010335 6.43 11.15 7.43 13.15 17.89 19.1 * + PLACE1010341 0.19 4.81 1.24 1.07 3.13 1.54 PLACE1010342 0.77 0.9 0.75 0.48 2.12 0.8 PLACE1010346 1.47 1.73 3.61 2.96 4.47 1.71 PLACE1010362 1.31 2.69 2.22 2.18 3.49 3.31 PLACE1010364 0.78 2.56 1.65 1.19 2.32 1.49 PLACE1010368 1.66 5.44 3.51 3.41 3.87 4.48 PLACE1010373 9.05 10.48 16.82 12.13 15.45 12.28 PLACE1010383 1.91 5.52 5.13 5.58 6.39 4.9 PLACE1010385 0.3 3.01 1.07 0.04 0.6 0.9 PLACE1010389 6.28 7.98 13.24 22.3 13.64 22.94 * + PLACE1010401 0.73 2.72 1.32 1.99 2.87 2.21 PLACE1010410 3.15 4.83 6.71 4.78 7.55 7.32 PLACE1010418 1.88 4.73 4.2 4.71 5.14 4.66 PLACE1010425 0.93 4.78 1.43 1.78 1.96 2.15 PLACE1010443 6.98 13.83 51.39 36.22 63.67 48.93 PLACE1010445 0.95 5.02 0.68 2.69 3.81 2.44 PLACE1010481 1.19 2.06 2.46 1.75 2 1.85 PLACE1010482 28.99 29.39 53.06 31.75 19.63 40.44 PLACE1010491 3.36 6.4 5.38 4.96 5.98 3.26 PLACE1010492 4 4.75 5.95 5.57 8.15 7.77 PLACE1010509 0.8 4.32 3.15 3.09 3.01 2.99 PLACE1010518 3.33 6.72 6.58 7.3 8.25 8.24 PLACE1010522 2.3 5.96 4.35 1.87 3.52 2.64 PLACE1010529 1.8 6.5 3.84 5.43 8.44 7.2 PLACE1010547 0.79 1.57 1.76 1.51 1.93 2.45 PLACE1010560 0.63 2.51 2.06 3.31 2.2 2.51 PLACE1010562 0.74 2.68 1.65 1.64 2.1 1.63 PLACE1010579 1.11 7.13 2.63 3.45 4.67 3.26 PLACE1010580 1.35 9.12 3.79 3.27 2.49 4.52 PLACE1010599 3.56 6.07 7.94 8.32 9.26 8.13 PLACE1010606 1.17 4.42 1.64 3.39 4.17 3.51 PLACE1010616 1.84 3.72 5.49 4.09 8.09 6.81 PLACE1010622 2.1 3.43 3.91 5.07 4.74 4.69 * + PLACE1010624 1.43 3.35 3.98 4.21 6.17 5.22 PLACE1010628 1.37 3.97 2.83 2.14 3.63 4.22 PLACE1010629 1.08 4.64 2.24 3.01 3.3 3.5 PLACE1010630 1.64 4.77 3.69 4.22 4.78 5.29 PLACE1010631 0.5 5.35 2.64 1.55 1.66 2.67 PLACE1010651 14.24 15.75 24.44 37.62 40.09 52.12 * + PLACE1010661 1.62 4.09 2.28 3.56 6.43 3.22 PLACE1010662 1.32 2.48 1.6 2.98 2.3 1.61 PLACE1010668 12.87 15.91 27.82 37.63 30.53 28.75 PLACE1010702 1.46 2.34 4.24 3.59 3.6 3.2 PLACE1010709 79.16 78.33 115.91 107.07 96.3 133.25 PLACE1010713 7 10.81 14.7 9.14 8.16 15.14 PLACE1010714 0.82 7.41 1.58 1.75 2.04 1.47 PLACE1010716 0.71 6.19 4.31 2.08 2.3 1.93 PLACE1010717 0.9 6.49 2.13 2.17 3.9 2.61 PLACE1010720 14.03 17.05 53.79 46.72 50.7 41.49 PLACE1010739 0.9 1.2 1.11 1.73 1.21 1.93 PLACE1010743 1.09 2.3 1.99 2.63 2.05 2.21 PLACE1010752 0.87 2.92 1.85 1.76 2.05 1.53 PLACE1010761 3.6 8.83 13.51 12.07 16.4 17.08 PLACE1010771 1.41 6.89 5.03 6.13 10.3 5.42 PLACE1010784 0.9 9.66 1.97 2.07 1.72 1.34 PLACE1010786 1.21 8.77 2.83 2.91 3.68 2.21 PLACE1010789 0.6 1.16 1.52 1.8 1.89 1.17 PLACE1010800 2.18 2.86 3.25 3.95 3.24 2.93 PLACE1010802 2.97 4.63 5.31 5.72 4.27 3.3 PLACE1010811 0.89 2.19 1.96 1.83 1.75 2.18 PLACE1010813 8.89 13.3 55.85 48.82 72.26 46.7 PLACE1010827 1.54 6.43 3.94 4.3 5.52 4.81 PLACE1010833 0.93 8.13 2.63 2.68 3.64 2.09 PLACE1010839 1.57 6.22 3.21 4.22 6.72 4.13 PLACE1010856 7.58 8.94 12.34 8.02 6.53 8.59 PLACE1010857 3.41 3.81 7.63 8.24 5.98 4.56 PLACE1010870 1.3 2.24 2.05 1.62 2.38 1.94 PLACE1010877 1.67 4.66 2.69 2.77 3.92 2.62 PLACE1010882 0.49 4.8 0.99 1.74 1.27 0.51 PLACE1010891 1.1 7.73 1.12 1.85 1.73 0.95 PLACE1010896 1.19 5.29 3.18 3.98 3.05 3.47 PLACE1010900 7.41 13.29 27.9 23.88 20.99 18.85 PLACE1010916 1.55 1.18 2.06 1.89 1.9 2.2 PLACE1010917 -0.04 0.82 0.36 1.05 2.25 0.56 PLACE1010924 1.15 2.31 1.55 1.11 1.88 0.92 PLACE1010925 2.76 5.36 2.17 4.92 6.32 4.16 PLACE1010926 1.8 5.73 4.31 5.37 4.35 4.45 PLACE1010942 1.7 6.25 5.63 5.53 7.88 7.69 PLACE1010943 7.38 10.43 17.12 24.62 29.5 31.96 ** + PLACE1010944 4.33 7.39 9.3 13.11 11.44 15.58 * + PLACE1010947 1.43 0.9 2.41 2.57 2.8 2.25 PLACE1010954 3.56 2.92 7.4 7.92 8.55 7.64 PLACE1010960 2.06 3.44 6.07 4.23 7.89 2.6 PLACE1010965 2.33 3.81 3.54 6.09 4.92 5.03 * + PLACE1010968 1.55 4.69 1.38 4.95 6.51 3.68 PLACE1010978 3.63 6.12 7.05 9 8.94 6.45 PLACE1010982 2.23 5.77 5.6 4.74 5.66 4.88 PLACE1010990 0.88 5.4 2.04 3.11 3.03 2.19 PLACE1011017 5.6 3.78 22.57 25.64 35.47 20.97 PLACE1011019 1.1 1.5 2.48 3.78 4.42 0.88 PLACE1011026 4.17 4.93 6.23 6 5.19 2.74 PLACE1011032 0.89 3.95 2.03 1.44 1.58 0.56 PLACE1011041 1.07 4.13 1.03 1.69 1.22 1.43 PLACE1011045 1.49 5.62 2.36 3.26 3.67 4.45 PLACE1011046 0.83 5.25 1.79 2.57 3.17 1.87 PLACE1011054 2.33 5.33 6.64 5.26 7.29 5.05 PLACE1011056 5.78 5.43 16.22 14.56 19.78 15.67 PLACE1011057 2 2.18 3.5 3.29 5.68 3.9 PLACE1011059 0.93 1.37 1.56 1.74 2.96 1.79 PLACE1011066 4.49 5.74 6.76 5.38 7.72 5.49 PLACE1011087 7.6 7.04 16.48 12.43 17.42 9.79 PLACE1011090 2.98 6.14 6.74 3.36 4.13 3.26 PLACE1011109 1.99 7.29 4.29 4.08 7.96 3.83 PLACE1011114 1.62 4.4 3.13 3.33 4.68 3.29 PLACE1011116 4.89 5.94 6.66 7.43 6.81 8.98 PLACE1011122 0.93 2.52 1.84 2.1 1.61 1.64 PLACE1011133 0.83 2.22 3.03 3.48 3.52 2.77 PLACE1011134 12.47 15.29 66.86 44.95 68.68 51.65 PLACE1011143 0.68 4.53 1.48 1.84 2.62 1.41 PLACE1011146 0.91 5.93 1.74 1.97 3.23 2.36 PLACE1011160 1.67 7.36 3.81 3.42 4.53 4.24 PLACE1011165 1.77 2.34 3.39 2.15 3.39 3.8 PLACE1011181 5.25 8.31 37.21 29.38 38.44 30.55 PLACE1011185 2.47 4 3.57 4.66 5.15 4.8 * + PLACE1011186 13.16 12.8 16.45 21.18 25.69 28.83 * + PLACE1011203 1.08 4.64 2.19 1.75 2.94 1.96 PLACE1011214 9.02 16.55 59.24 46.39 62.58 47.89 PLACE1011219 1.41 4.91 3.6 3.26 4.96 2.9 PLACE1011221 2.68 5.47 6.15 6.23 8.57 7.51 PLACE1011229 1.38 4.2 2.69 2.43 2.43 3.09 PLACE1011231 0.53 1.5 1.62 1.84 2.59 2.4 PLACE1011236 5.69 7.9 43.53 33.48 56.77 44.25 PLACE1011247 8.36 10.08 19.16 24.17 26.33 29.74 * + PLACE1011263 0.57 6.43 4.23 2.62 4.11 5.09 PLACE1011273 0.72 3.62 1.17 2.01 1.64 1.72 PLACE1011278 2.42 5 6.12 3.98 4.84 4.31 PLACE1011289 2.73 5.84 7.57 6.34 6.13 6.08 PLACE1011291 3.2 5.19 8.31 7.32 8.04 7.95 PLACE1011296 0.93 2.45 1.94 1.76 2.63 2.05 PLACE1011310 1.72 2.64 3.36 4.51 2.77 4.48 PLACE1011311 1.8 3.97 6.33 7.8 9.34 6.73 PLACE1011321 1.29 4.77 3.5 3.3 2.63 3.33 PLACE1011325 0.63 4.2 1.84 2 2.74 1.59 PLACE1011332 5.65 10.55 9.4 14.8 14.57 15.04 * + PLACE1011340 0.86 4.88 3.38 3.81 4.71 3.47 PLACE1011353 5.39 5.53 8.39 10.06 8.58 4.43 PLACE1011360 1.09 3.29 2.18 2.11 3.06 2.41 PLACE1011364 4.88 5.69 7.92 6.34 4.57 4.57 PLACE1011365 0.92 3.36 2.95 3.01 3.6 2.06 PLACE1011371 9.37 10.69 63.06 56.51 87.51 64.33 PLACE1011375 1.62 9.37 3.35 2.61 2.74 1.62 PLACE1011386 3.91 12.96 4.18 6.88 5.51 5.93 PLACE1011399 1.52 10.14 4.27 2.12 4.22 3.77 PLACE1011406 1.25 2.05 1.81 5.03 3.26 2.38 PLACE1011407 0.64 2.05 2.58 2.08 2.19 2.02 PLACE1011419 2.83 3.2 6.02 6.23 4.18 3.72 PLACE1011433 3.09 4.43 6.13 3.41 4.74 4.99 PLACE1011440 0.77 5.81 2.48 2.1 2.24 2.27 PLACE1011452 1.06 8.86 2.43 2.87 2.71 2.68 PLACE1011465 0.09 8.53 1.96 1.04 1.68 0.85 PLACE1011472 1.52 7.67 3.98 0.97 2.87 1.59 PLACE1011477 11.18 12.29 54.35 31.86 55.86 45.67 PLACE1011478 1.24 1.64 3.11 5.03 3.02 3.01 PLACE1011492 2.24 3.54 5.01 5.45 6.74 5.27 PLACE1011498 0.57 2.77 0.98 1.18 1.69 1.15 PLACE1011501 0.49 4.67 1.8 4.87 5.63 7.5 PLACE1011503 0.44 5.37 0.79 0.5 0.82 0.35 PLACE1011509 1.1 7.8 3.38 4.62 5.08 5.74 PLACE1011514 5.86 11.61 11.98 13 17.7 13.17 PLACE1011516 10.37 13.29 18.32 18.32 8.08 3.63 PLACE1011520 0.34 0.95 1.34 1.3 1.73 1.01 PLACE1011538 52.87 99.27 185.04 129.45 86.87 63.9 PLACE1011555 0.87 2.88 2.83 1.55 2.03 1.48 PLACE1011561 3.2 4.53 1.98 6.81 5.31 3.08 PLACE1011563 1.35 4.74 3.49 2.52 2.64 2.87 PLACE1011567 1.04 4.94 3.36 2.75 4.19 2.77 PLACE1011569 0.32 4.35 2.77 2.38 2.46 2.28 PLACE1011576 3.25 1.88 7.94 7.85 9.1 8.03 PLACE1011586 3.24 2.5 6.22 4.43 4.35 2.94 PLACE1011635 1.85 2.56 4.53 9.96 12.43 8.71 ** + PLACE1011641 0.43 2.9 0.9 1.71 1.18 1.19 PLACE1011642 5.05 6.96 10.37 12.13 10.86 10.09 PLACE1011643 1.29 3.69 1.14 2.38 2.28 2.14 PLACE1011646 8.68 12.8 30.53 39.05 54.16 37.76 * + PLACE1011649 1.35 5.7 3.88 4.5 4.61 5.46 PLACE1011650 1.15 1.45 2.54 2.47 3.24 3.75 PLACE1011661 1.02 2.26 2.8 3.95 5.92 3.46 PLACE1011664 2.21 3.18 3.99 5.31 3.93 1.73 PLACE1011672 0.88 4.14 0.72 2.69 3.57 2.04 PLACE1011675 0.51 2.31 1.32 1.66 0.99 0.83 PLACE1011682 2.04 4.56 2.23 2.22 4.03 2.12 PLACE1011708 1.1 5.89 3.8 5.5 8.12 4.66 PLACE1011719 1.07 4.58 1.66 3.55 3.88 3.03 PLACE1011725 1.23 1.19 2.72 3.73 5.19 4.3 * + PLACE1011729 0.86 1.03 1.8 2.38 3.26 1.22 PLACE1011741 2.36 3.67 3.64 4.16 2.52 4.23 PLACE1011749 1.58 3.89 4.09 3.49 4.85 3.27 PLACE1011757 20.92 30.53 55.88 56.6 55.88 49.59 PLACE1011762 0.4 4.34 2.69 3.91 2.14 2.3 PLACE1011778 0.51 4.39 1.99 1.34 2.02 1.34 PLACE1011783 2.59 4.63 5.46 4.8 8.41 5.55 PLACE1011795 0.74 1.28 2.24 1.47 1.8 1.22 PLACE1011810 9.28 10.82 19.51 13.32 17.73 15.47 PLACE1011824 5.38 8.17 38.05 25.52 42.89 16.75 PLACE1011825 10.61 16.39 22.6 17.63 18.92 16.07 PLACE1011835 24.64 32.67 47.67 32.09 26.75 37.23 PLACE1011836 18.11 18.97 31.43 33.14 47.23 13.95 PLACE1011847 2.67 6.74 6.42 5.34 7.18 5.84 PLACE1011855 0.9 6.06 3.53 3.23 4.47 3.49 PLACE1011858 5.83 7.44 9.37 6.88 6.25 8.35 PLACE1011874 1.35 3.14 3.55 4.18 5.28 4.65 PLACE1011875 0.57 2.29 1.11 2.66 2.48 2.64 PLACE1011877 3.8 5.03 4.4 7.67 6.8 9.97 * + PLACE1011891 0.17 3.81 1.31 1.13 1.34 1.26 PLACE1011896 -0.1 5.22 1.45 -0.19 1.07 0.32 PLACE1011920 0.21 5.87 1.04 1.1 1.92 1.76 PLACE1011922 2.4 4.18 4.72 3.72 2.88 3.98 PLACE1011923 3.42 4.82 7.51 8.09 5.38 12.28 PLACE1011937 3.16 2.24 3.76 3.81 5.58 4.64 PLACE1011939 14.93 17.81 26.01 41.75 45.05 47.88 ** + PLACE1011940 6.13 7.58 12.68 5.73 7 7.23 PLACE1011962 3.28 7.83 7.35 6.39 8.38 8.01 PLACE1011964 0.39 5.05 1.66 1.04 1.95 1.46 PLACE1011978 1.55 4.65 3.35 4.48 5.91 5.14 PLACE1011980 2.1 4.62 6.07 3.95 4.91 5.35 PLACE1011981 5.77 7.28 38.2 27.22 35.24 34.99 PLACE1011982 0.83 3.1 2.23 1.82 2.59 1.57 PLACE1011995 0.81 3.4 3.73 2.51 3.59 2.86 PLACE1012023 1.38 5.37 1.87 2.09 2.46 1.91 PLACE1012026 1.95 5.72 4.23 6.08 9.51 9.8 PLACE1012031 2.49 5.81 4.54 4.34 6.35 4.03 PLACE2000003 1.18 3.64 6.86 7.38 8.12 8.92 PLACE2000005 1.16 2.41 2.16 2.76 2.03 1.89 PLACE2000006 2.52 4.13 15.6 11.34 16.58 13.4 PLACE2000007 0.96 4.85 4.24 3.94 5.13 3.33 PLACE2000011 1.72 3.27 3.34 4.3 5.06 3.62 PLACE2000014 4.04 5.93 23.94 27.19 30.87 30.97 * + PLACE2000015 1.27 4.79 3.52 2.77 3.31 2.69 PLACE2000017 0.48 4.78 2.15 2.65 2.56 2.45 PLACE2000021 1.99 5.06 4.09 3.72 6.24 5.61 PLACE2000022 1.8 2.8 4.31 3.35 4.64 2.71 PLACE2000030 9.37 11.08 71.38 55.43 60.32 35.97 PLACE2000032 1.23 2.89 3.51 3.53 3.24 2.32 PLACE2000033 3.29 6.3 12.11 12.49 14.25 9.37 PLACE2000034 0.6 4.3 1.92 1.79 2.19 2.44 PLACE2000039 2.75 8.06 3.92 6.27 8.01 4.81 PLACE2000043 7 11.08 22.94 19.27 26.58 17.38 PLACE2000044 0.63 6.92 1.12 1.8 1.71 1.29 PLACE2000047 0.84 5.25 5.15 5.4 6.46 7.32 PLACE2000050 1.48 2.68 4.78 2.92 2.98 1.2 PLACE2000061 0.47 2.07 1.17 0.95 1.34 0.25 PLACE2000062 1.99 2.83 4.12 4.89 4.4 3.09 PLACE2000072 0.78 2.45 1.57 1.85 1.62 1.69 PLACE2000073 0.89 5.86 2.86 2.8 2.61 3.07 PLACE2000097 8.54 19.93 23.93 27.69 35.36 26.36 PLACE2000100 1.87 7.79 3.53 4.23 6.29 4.22 PLACE2000103 1.03 7.44 2.25 3.51 5.17 4.38 PLACE2000106 1.53 2.42 4.19 5.71 3.29 4.01 PLACE2000111 2.05 3.17 4.37 4.07 6.6 4.75 PLACE2000115 0.3 2.06 0.75 0.31 1.29 0.97 PLACE2000118 10.15 17.04 21.09 13.73 15.21 22.01 PLACE2000124 10.14 17.83 62.13 53.2 98.37 62.96 PLACE2000132 0.06 6.26 1.48 0.99 1.5 1.56 PLACE2000136 0.55 7.94 0.91 1.47 1.37 1.02 PLACE2000137 0.96 4.46 2.4 2.65 4.12 3.14 PLACE2000140 2.91 5.24 14.34 13.2 12.08 9.43 PLACE2000147 1.49 1.52 2.83 1.06 0.97 1.12 PLACE2000153 0.3 3.44 2.15 1.69 2.45 1.95 PLACE2000164 0.66 2.78 1.13 2.66 1.62 1.62 PLACE2000170 1.54 6.18 4.69 5.26 9.09 6.24 PLACE2000172 0.33 4.34 2.15 1.25 1.93 2.43 PLACE2000173 0.92 4.97 3.37 3.33 3.71 2.74 PLACE2000174 1.17 4.68 2.43 1.85 2.89 2.05 PLACE2000176 1.22 1.57 2.58 3.28 2.27 1.42 PLACE2000187 1.01 2.08 2.55 3.45 3.66 2.19 PLACE2000216 7.03 9.28 11.47 14.09 9.13 3.68 PLACE2000219 0.69 4.02 2.72 3.55 3.58 2.3 PLACE2000221 2.49 6.81 6.53 7.22 9.33 8.56 PLACE2000223 0.72 3.2 1.71 1.16 1.05 0.48 PLACE2000231 1.02 3.97 3.11 3.43 2.61 2.47 PLACE2000235 1.82 5.27 6.17 6.02 7.45 6.97 PLACE2000246 1.93 2 6.06 4.58 5.09 3.93 PLACE2000264 0.67 1.39 1.85 2.45 3.74 3 * + PLACE2000274 0.65 2.4 2.12 3.09 4.11 2.1 PLACE2000287 0.81 4.44 1.49 2 2.59 1.34 PLACE2000296 1.01 4.56 1.55 2.5 3.16 1.69 PLACE2000302 1.34 4.67 2.86 3.52 3.35 3.45 PLACE2000305 3.09 6.65 5.42 6.3 7.15 5.02 PLACE2000317 0.92 6.34 2.26 3.15 2.95 2.4 PLACE2000324 1.19 1.25 3.09 4.2 5.84 3.3 PLACE2000334 3.52 5 6.6 7.33 8.12 5.88 PLACE2000335 1.47 4.35 4.24 5.68 6.25 4.76 PLACE2000340 0.64 3.47 1.63 1.58 1.52 1.65 PLACE2000341 4.21 7.87 28.81 18.94 32.45 19.16 PLACE2000342 2.07 5.11 4.32 4.84 5.82 4.49 PLACE2000347 1.24 5.26 5.58 7.83 6.22 7.55 PLACE2000357 8.49 13.56 15.35 17.83 18.98 21.24 * + PLACE2000358 2.87 3.65 8.67 4.88 7.63 4.37 PLACE2000359 1.27 1.79 4.45 3.28 6.65 3.61 PLACE2000366 1.93 3.14 3.22 3.99 5.6 4.17 PLACE2000371 4.29 5.2 6.08 5.95 9.06 7.32 PLACE2000373 1.91 4.8 5.98 5.69 6.29 4.19 PLACE2000374 1.86 5.17 2.78 1.62 2.79 1.49 PLACE2000379 0.34 4.85 1.32 1.28 0.92 0.04 PLACE2000386 39.29 43.92 84.66 87.53 104.55 76.56 PLACE2000388 1.96 3.35 3.89 2.78 3.48 3.49 PLACE2000392 33.29 39.2 59.56 42.5 52.12 58.24 PLACE2000394 1.26 3.27 3.01 5.69 4.35 4.34 * + PLACE2000398 0.73 3.88 2.36 2.03 3.59 1.35 PLACE2000399 3.7 6.82 7.01 7.15 7 6.79 PLACE2000402 2.15 6.88 3.84 2.86 3.68 3.9 PLACE2000404 5.2 9.96 10.67 10.03 11.04 6.47 PLACE2000411 3.21 7.2 5.21 5.27 5.73 6.68 PLACE2000418 0.73 2.28 2.41 2.22 3.07 2.37 PLACE2000419 0.99 2.32 2.54 4.95 4.55 3.29 * + PLACE2000425 1.26 3.98 3.11 4.28 4.81 5.2 PLACE2000427 0.7 5.13 3.27 2.54 3.04 2.47 PLACE2000433 0.77 7.05 2.6 2.33 3.09 2.46 PLACE2000435 0.48 5.19 1.49 1.69 1.63 1.5 PLACE2000438 1.61 4.74 3.66 2.33 2.81 3.15 PLACE2000450 3.01 4.38 5.67 6.51 7.39 5.63 PLACE2000455 0.24 2.62 1.24 1.65 2 1.82 PLACE2000458 0.38 3.3 1.81 1.06 2.7 1.24 PLACE2000464 2.15 4.91 5.3 7.43 9.68 8.83 * + PLACE2000465 1.43 6.72 6 6.51 8.27 6.31 PLACE2000473 120.94 179.35 328.3 214.7 297.75 279.74 PLACE2000477 0.43 3.87 1.34 1.13 2.22 0.97 PLACE3000004 2.22 4.63 6.39 5.27 7.51 5.2 PLACE3000009 19.91 19.71 105.63 77.3 140.99 92.95 PLACE3000020 10.03 9.03 49.6 36.74 46.52 23.82 PLACE3000029 6.59 9.63 24.88 14.88 18.47 20.04 PLACE3000038 0.52 2.37 2.47 1.44 2.4 2.05 PLACE3000052 5.13 7.95 23.92 25.01 29.61 24.94 PLACE3000059 0.57 5 2.42 0.75 2.8 1.27 PLACE3000067 2.51 5.79 7.44 5.66 8.53 7.75 PLACE3000069 1.95 5.61 3.58 5.24 3.79 4.55 PLACE3000070 2.57 5.57 9.04 9.5 10.42 10.57 PLACE3000103 3.85 7.84 11.87 6.6 8.32 4.37 PLACE3000119 1.59 2.74 3.15 3.24 3.67 2.95 PLACE3000121 7.58 8.44 38.1 30.63 42.28 32.64 PLACE3000124 1.53 4.54 5.95 6.35 7.75 7.18 PLACE3000135 0.69 5.46 1.1 0.76 0.9 0.59 PLACE3000136 0.77 10.46 4.46 2.12 2.77 2.01 PLACE3000142 0.7 9.94 1.75 1.53 2.76 1.13 PLACE3000145 8.69 17.55 55.33 42.85 49.12 39.96 PLACE3000147 15.7 12.92 39.97 64.96 54.76 30.34 PLACE3000148 0.7 2.08 1.48 0.82 1.4 1.38 PLACE3000154 0.48 1.86 0.67 1.5 0.87 0.44 PLACE3000155 1.28 4.26 2.53 3.97 4.76 3.04 PLACE3000156 1.11 7.96 2.07 1.96 3.4 2.81 PLACE3000157 0.92 8.37 1.75 2.06 3.02 2.72 PLACE3000158 1.73 8.82 5.05 3.81 5.63 4.77 PLACE3000160 8.11 15.22 19.5 33.66 34.71 33.78 ** + PLACE3000169 2.15 2.65 6.87 4.3 5.11 5.12 PLACE3000181 1.06 2.14 3.94 3.22 2.62 3 PLACE3000194 0.31 2.83 1.77 1.89 2.58 2.42 PLACE3000197 1.18 2.66 2.09 2.42 2.46 2.21 PLACE3000199 0.22 4.8 1.63 0.55 0.86 0.43 PLACE3000205 11.79 17.95 57.49 51.4 63.83 42.63 PLACE3000207 3.37 6.91 7.13 6.7 8.92 6.23 PLACE3000208 2.26 4.96 2.66 5.28 5.97 5.84 PLACE3000213 4.79 5.55 10.8 5.12 5.16 5.05 PLACE3000215 1.88 5.02 5.71 4.74 5 3.03 PLACE3000218 0 1.63 1.18 0.97 0.62 0.31 PLACE3000220 1.96 3.55 4.58 6.74 7.52 6.69 * + PLACE3000221 14.42 25.34 40.15 43.8 51.16 36.99 PLACE3000225 1.15 4.68 3.11 2.11 2.67 1.28 PLACE3000226 1.37 5.65 5.16 3.78 7.42 3.68 PLACE3000230 0.83 3.46 1.36 2 2.8 1.73 PLACE3000231 1.31 1.97 2.37 4.86 3.95 4.12 ** + PLACE3000235 1.12 1.75 3.89 3.95 4.21 3.39 PLACE3000242 2.6 5.11 9.24 9.46 10.97 8.29 PLACE3000244 1.05 3.2 1.81 1.85 1.81 0.64 PLACE3000253 0.7 3.75 1.64 2.67 2.11 1.27 PLACE3000254 2.5 4.75 4.04 6.19 6.09 5.75 * + PLACE3000271 2.67 6.06 6.81 10.96 10.99 9.5 * + PLACE3000276 1.1 5.78 2.27 1.48 1.9 1.78 PLACE3000304 5.55 4.69 10.81 11.19 11.49 10.5 PLACE3000309 0.43 1.67 1.87 2.43 2.94 2.78 * + PLACE3000310 2.19 2.19 3.73 4.84 4.81 3.4 PLACE3000320 1.02 3.65 1.8 2.54 2.37 2.32 PLACE3000322 1.31 4.23 6.63 7.5 7.8 6.09 PLACE3000330 24.05 24.44 41.08 31.87 35.83 29.17 PLACE3000331 1.21 5.86 4.14 4.34 5.7 4.31 PLACE3000336 2.61 6.99 4.42 4.24 5.72 5.11 PLACE3000339 7.36 5.1 11.41 16.25 18.28 17.37 ** + PLACE3000341 1.65 1.32 2.41 4.08 4.35 3.65 ** + PLACE3000350 5.88 6.4 12.86 15.45 18.5 15.41 * + PLACE3000352 1.54 3.88 2.13 2.37 2.25 1.71 PLACE3000353 5.38 9.72 11.8 19.12 22.98 15.5 * + PLACE3000362 0.62 4.92 4.72 3.61 5.33 3.39 PLACE3000363 2.19 5.13 2.32 1.89 3.28 2.07 PLACE3000365 1.34 6.11 3.37 3.34 4.05 2.12 PLACE3000373 0.89 1.52 3.66 2.93 6.08 2.3 PLACE3000374 1.07 1.85 2.91 2.72 2.99 2.15 PLACE3000387 0.31 3.32 1.04 1.24 1.65 1.29 PLACE3000388 1.18 3.22 1.94 2.76 3.49 2.22 PLACE3000399 2.12 4.66 6.28 7.42 9.84 6.05 PLACE3000400 3.08 5.44 11.87 7.97 10.77 7.82 PLACE3000401 7.52 11.42 18.59 22.61 29.55 23.4 * + PLACE3000402 1.79 3.21 3.4 2.19 1.74 1.79 PLACE3000405 3.37 3.74 5.82 5.54 7.22 6.01 PLACE3000406 2.1 2.91 3.11 3.48 3.68 2.42 PLACE3000413 1.18 2.72 2.69 1.71 2.06 1.52 PLACE3000416 1.05 4.03 4.04 3.43 2.67 2.72 PLACE3000425 1.21 6.27 4.33 3.98 6.36 3.92 PLACE3000437 4.79 10.85 29.89 16.69 25.26 19.14 PLACE3000455 2.97 8.07 10.62 8.97 10.39 7.91 PLACE3000475 16.52 19.2 47.35 40.22 39.77 34.21 PLACE3000477 5.44 4.79 5.56 8.05 5.52 8.42 PLACE4000003 0.38 2.97 1.61 3.14 2.33 2.31 PLACE4000008 15.19 11.38 16.76 13.05 14.26 8.84 PLACE4000009 1.17 6.19 3.39 3.93 3.37 1.82 PLACE4000014 1.31 5.12 1.77 2.16 3.03 2.19 PLACE4000029 6.33 8.48 35.37 23.93 32.21 24.25 PLACE4000034 2.27 6.24 5.22 6.46 6.52 4.91 PLACE4000049 3.39 3.35 5.21 3.85 5.82 4.86 PLACE4000052 1.41 3.36 2.2 2.62 2.64 2.02 PLACE4000062 1.6 4.94 5.06 4.25 5.06 3.71 PLACE4000063 2.59 6.87 5.19 4.86 4.81 3.73 PLACE4000089 1.52 6.31 3.35 2.81 3.91 2.84 PLACE4000093 0.44 5.6 1.61 1.28 1.65 1.98 PLACE4000100 2.72 6.13 4.75 4.33 3.62 3.94 PLACE4000103 0.63 4.48 5.64 4.4 5.67 2.9 PLACE4000106 3.2 5.33 6.63 7.1 5.13 7.21 PLACE4000128 1.93 3.97 4.88 4.15 4.96 4.4 PLACE4000129 0.74 3.26 1.64 1.57 2.11 1.78 PLACE4000131 7.14 10.85 41.43 32.45 41.08 31.22 PLACE4000147 0.34 3.65 0.54 0.45 0.93 0.61 PLACE4000156 2.47 6.08 8.06 7.83 13.47 9.07 PLACE4000175 0.72 4.08 1.48 0.98 0.91 0.84 PLACE4000190 14.55 18.47 70.34 49.15 74.82 60.76 PLACE4000192 1.3 2.27 3.6 2.36 2 1.25 PLACE4000206 5.35 6.65 12.44 7.13 7.1 6.02 PLACE4000211 3.34 4.64 22.23 11.68 12.35 13.44 PLACE4000214 0.86 3.61 2.68 2.08 2.53 1.69 PLACE4000222 0.93 5.28 4.36 4.13 4.75 3.5 PLACE4000223 0.46 4.51 1.79 1.37 1.22 0.38 PLACE4000229 1.9 5.79 2.11 2.81 3.36 3.48 PLACE4000230 1.11 5.89 6.51 3.61 6.81 5.15 PLACE4000233 1.26 3.02 5.66 2.92 2.98 3.51 PLACE4000239 2.35 3.68 4.17 4.19 3.97 3.35 PLACE4000247 0.52 2.37 3.38 2.64 3.1 2.35 PLACE4000250 1.18 3.24 2.35 3.33 3.68 2.8 PLACE4000252 1.06 4.99 2.25 1.92 1.75 1.64 PLACE4000259 4.42 11.95 18.1 14.47 22.09 14.02 PLACE4000261 0.87 10.29 1.07 2.03 1.9 1.12 PLACE4000264 15.86 24.96 36.9 11.96 21.82 22.51 PLACE4000269 3.48 3.71 7.95 4.62 4.55 2.85 PLACE4000270 0.43 1.42 1.87 1.75 1.83 0.59 PLACE4000281 17.84 20.97 44.05 32.93 28.37 28.87 PLACE4000300 0.67 2.06 2.04 3.21 2.88 3.58 * + PLACE4000320 1.33 5.86 3.1 2.84 5.32 3.21 PLACE4000323 1.63 7.43 5.13 4.03 4.65 4.82 PLACE4000326 1.8 10.98 5.67 5.72 8.73 5.59 PLACE4000344 0.22 5.75 2.62 1.66 1.6 1.18 PLACE4000347 4.7 3.82 13.93 16.83 16.75 17.36 * + PLACE4000354 3.18 6.29 10.68 5.17 2.81 2.79 PLACE4000367 0.79 2.97 1.71 0.87 1.3 1.38 PLACE4000369 1.35 3.97 2.36 1.99 1.96 0.82 PLACE4000379 2.44 6.66 5.44 5.94 7.55 5.07 PLACE4000387 0.88 5.86 2.11 1.28 0.84 1.12 PLACE4000392 0.42 5.58 1.32 1.81 1.02 1.63 PLACE4000399 10.99 17.08 75.17 59.11 80.22 58 PLACE4000401 0.72 0.7 1.53 1.17 0.83 1.4 PLACE4000403 3.15 4.13 8.51 5.29 6.38 5.87 PLACE4000411 2.22 2.28 4 2.27 2.6 1.82 PLACE4000415 0.7 3.55 2.8 1.16 1.86 0.78 PLACE4000416 25.49 29.13 33.54 23.65 21.92 24.83 PLACE4000424 1.61 5.59 3.33 3.27 3.92 2.51 PLACE4000431 3.89 7.39 21.01 17.68 28.21 16.79 PLACE4000443 0.07 4.33 2.15 1.52 2.83 1.14 PLACE4000445 3.94 5.43 9.98 7.62 6.99 6.27 PLACE4000450 2.99 3.65 23.28 15.51 24.53 16.04 PLACE4000455 5.18 7.39 9.55 8 7.21 4.63 PLACE4000465 1.39 4.34 3.26 4.15 6.07 4.34 PLACE4000466 120.96 98.04 201.25 113.83 170.96 145.31 PLACE4000472 3.12 9.6 10.17 10.92 13.21 9.22 PLACE4000487 3.18 7.83 16.5 14.66 16.62 15.05 PLACE4000489 0.93 4.69 3.41 1.95 3.88 1.69 PLACE4000494 1.15 1.6 4.07 2.74 3.1 2.08 PLACE4000502 6.3 5.39 10.92 11.65 15.08 6.37 PLACE4000521 2.5 3.44 16.06 12.78 20.63 11.2 PLACE4000522 5.07 6.17 9.07 12.43 8.68 14.11 PLACE4000537 0.98 4.28 1.27 1.67 1.61 1.22 PLACE4000548 1.99 5.69 2.46 3.04 3.68 2.32 PLACE4000558 0.87 6.72 1.97 3.15 2.41 2.15 PLACE4000581 2.1 7.22 7.04 3.9 5.96 5.44 PLACE4000590 0.4 0.61 0.15 0.4 0.81 -0.25 PLACE4000593 2.94 2.98 5.22 4.44 5.82 3.83 PLACE4000612 0.68 3.33 3.33 1.5 3.02 2.74 PLACE4000638 1.25 4.24 0.84 1.2 1.44 1.58 PLACE4000650 0.82 4.67 1.02 1.43 1.11 1.16 PLACE4000651 2.42 6.4 7.48 5 7.01 6.07 PLACE4000654 0.98 5.7 2.47 1.35 2.48 1.47 PLACE4000670 0.5 4.06 2.92 0.76 1.29 0.67 PLACE4000685 6.35 8.68 13.83 13.46 14.26 13.77 PLACE4000687 0.37 3.02 1.11 2.2 1.4 1.12 PLACE5000003 1.1 2.74 3.31 3.21 3.55 3.07 PLACE5000005 12.43 16.53 27.36 24.54 24.57 24.76 PLACE5000019 0.4 4.15 1.13 0.59 1.89 0.79 PLACE5000021 0.74 4.59 1.61 0.39 0.93 0.32 PLACE5000022 1.2 6.11 2.25 3.17 2.76 2.09 PLACE5000024 1.77 2.58 2.27 2.92 3.39 3.84 * + PLACE5000036 1.81 3.24 3.11 2.41 3.19 2.84 PLACE5000059 14.41 17.79 26.55 25.98 30.03 34.87 PLACE5000076 1.41 3.61 2.22 4.04 3.96 2.54 PLACE5000117 7.44 12.48 15.66 16.87 18.78 20.64 PLACE5000143 0.85 6.45 2.11 1.67 2.85 2.73 PLACE5000152 0.42 4.49 1.23 1.61 1.95 1.57 PLACE5000154 18.23 23.5 45.06 21.81 25.65 31.8 PLACE5000155 3.35 2.81 5.51 3.94 2.78 4.87 PLACE5000165 3.78 4.4 6.67 4.51 5.99 5.82 SKNMC1000004 9.7 11.62 16.77 10.19 12.16 13.96 SKNMC1000011 1.82 8.58 4.12 5.89 3.95 6.77 SKNMC1000013 0.51 6.69 1.13 1.21 2.14 1.44 SKNMC1000014 1.28 4.18 3.22 3.77 6.37 3.96 SKNMC1000018 3.42 5.19 5.25 5.51 5.68 3.44 SKNMC1000020 0.95 4.03 3.46 3.6 4.68 4.56 SKNMC1000046 2 3.17 3.48 3.95 3.26 2.55 SKNMC1000050 4.99 8.04 10.32 5.4 6.28 6.12 SKNMC1000062 9.79 12.6 20.18 19.2 15.42 18.73 SKNMC1000075 1.45 4.3 2.01 1.98 1.89 2.92 SKNMC1000082 1.12 4.39 2.13 1.85 1.78 2.39 SKNMC1000091 4.54 7.52 7.95 11.74 12.86 12.77 ** + SKNMC1000099 0.33 4.29 1.98 1.32 0.65 1.18 SKNMC1000104 1.13 4.24 3.45 1.47 3.14 2.43 SKNMC1000113 0.97 1.83 1.2 1.74 2.63 0.89 SKNMC1000119 1.73 2.64 5.07 4.48 5.34 4.67 SKNMC1000142 0.04 2.87 0.99 1.27 0.75 1 SKNMC1000170 0.91 4.75 2.34 1.71 1.49 1.11 SKNMC1000178 3.02 8.39 7.08 5.77 9.65 9.02 SKNMC1000194 0.63 9.82 1.51 0.61 1.73 1.3 SKNMC1000198 1.35 11.01 3.33 2.65 2.1 2.88 SKNMC1000225 1.35 6.44 2.97 2.39 3.4 3.26 SKNMC1000249 0.49 2.14 0.75 0.57 0.51 0.52 SPLEN1000007 0.74 2.15 2.11 1.7 2.26 1.99 SPLEN1000012 0.39 1.9 1.72 1.19 0.8 0.84 SPLEN1000014 1.78 4.4 4.9 5.75 4.33 3.99 SPLEN1000036 4.95 11.64 24.32 20.56 27.73 21.68 SPLEN1000059 0.04 6.69 1.06 0.91 1.79 1.47 SPLEN1000068 1.68 10.81 5.71 5.79 5.17 5.64 SPLEN1000072 1 8.5 4.7 2.82 3 2.21 SPLEN1000101 20.01 18.4 45.64 29.93 25.24 12.63 SPLEN1000108 0.56 1.54 0.98 0.75 1.11 0.76 SPLEN1000113 1.33 2.27 3.04 2.72 4.13 3.04 SPLEN1000114 2.97 4.19 6.03 3.59 4.76 6.32 SPLEN1000132 0.85 4 1.72 2.25 2.67 1.99 SPLEN1000135 3.13 8.76 14.93 11.12 15.28 10.52 SPLEN1000136 12.41 21.47 15.14 20.24 27.48 21.8 SPLEN1000141 2.26 7.07 10.79 4.03 5.41 4.51 SPLEN1000164 2.49 3.79 8.58 3.98 5.88 7.61 SPLEN1000166 0.4 2.9 2.96 1.67 1.19 1.68 SPLEN1000175 2.16 4.48 6.1 5.65 4.12 4.15 SPLEN1000182 0.98 2.66 0.23 0.83 0.6 0.67 SPLEN1000185 3.41 8.49 8.54 11.38 10.43 11.95 THYMU1000004 10.22 14.07 20.43 22.34 22.76 23.6 THYMU1000009 9.48 10.13 14.9 13.48 23.86 22.1 THYMU1000015 8.87 10.42 16.18 19.25 22.21 20.8 * + THYMU1000016 6.24 5.96 13.03 10.3 8.45 9.38 THYMU1000023 0.77 1.86 3.6 5.22 3.68 3.6 THYMU1000034 0.16 1.77 1.8 0.79 0.88 0.14 THYMU1000035 0.62 2.8 0.97 1.17 0.95 1.31 THYMU1000037 1.53 4.15 2.11 2.06 2.81 1.45 THYMU1000042 5.97 10.24 12.23 12.03 13.98 13.28 THYMU1000047 2.72 6.03 6.72 6.04 7.77 7.23 THYMU1000080 0.56 4.31 2.6 3.26 1.85 2.11 THYMU1000094 2.77 3.47 7.91 9.17 8.35 4.55 THYMU1000109 17.28 14.34 111.37 98.05 142.29 93.04 THYMU1000127 2.75 5.95 10.76 8.18 9.98 6.74 THYMU1000130 2.5 4.4 4.55 6.69 6.07 4.94 THYMU1000137 3.53 7.18 10.26 12.67 18.55 13.05 * + THYMU1000146 4.37 8.38 6.52 8.29 7.46 7.74 THYMU1000159 5.43 9.51 16.37 12.4 15.15 13.27 THYMU1000163 5.85 12.26 37.58 45.53 58.37 36.93 THYMU1000167 2.39 3.02 4.73 4.89 6.79 3.97 THYMU1000186 0.69 1.05 1.45 1.31 2.45 0.66 THYRO1000017 0.94 3.45 2.54 2.02 3.54 2.11 THYRO1000026 1.56 5.63 4.02 3.96 4.82 3.36 THYRO1000034 0.49 4.16 1.59 1.99 2 1.82 THYRO1000035 0.86 4.84 1.34 2.29 2.48 2.11 THYRO1000036 0.93 8.32 4 3.08 4.36 5.59 THYRO1000040 2.58 7.02 4.76 4.66 4.83 4.93 THYRO1000061 2.01 1.91 3.07 3.53 3.8 2.61 THYRO1000067 1.98 2.8 5.12 3.37 4.14 3.3 THYRO1000070 1.26 2.09 3.59 2.65 3.85 3.45 THYRO1000072 1.33 3.37 4.22 2.54 4.08 2.06 THYRO1000084 8.07 12.69 22.39 2.99 5.61 4.42 THYRO1000085 1.44 5.66 3.99 2.42 3.86 2.85 THYRO1000086 -0.05 5.46 1.74 0.89 1.18 1.15 THYRO1000087 0.72 3.86 1.01 0 0.58 0.17 THYRO1000092 2.32 5.1 4.66 3.75 4.43 4.5 THYRO1000093 0.35 3.24 0.83 1.54 1.27 0.95 THYRO1000099 0.45 2.53 2.73 2.8 1.67 2.39 THYRO1000107 0.5 2.95 2.7 2.86 3.22 2 THYRO1000111 0.85 4.58 1.78 1.4 2.06 2.36 THYRO1000121 1.33 5.72 2.52 1.94 2.4 2.95 THYRO1000124 0.27 5.55 0.64 0.86 0.89 0.64 THYRO1000129 0.36 2.1 0.11 0.94 1.11 0.92 THYRO1000130 1.82 3.11 3.13 3.85 3.01 2.39 THYRO1000132 2.4 3.62 9.43 11.14 6.99 6.26 THYRO1000134 1.5 4.07 3.22 4.06 3.65 3.73 THYRO1000144 1.72 4.78 3.15 7.87 7.09 2.33 THYRO1000155 1.6 4.1 1.45 1.77 1.9 2.23 THYRO1000156 1.13 6.53 3.62 2.45 4.29 2.58 THYRO1000163 3.62 8.42 5.28 4.76 6.63 2.24 THYRO1000173 1.19 4.45 2.26 3.33 1.36 2.75 THYRO1000186 1.98 3.24 7.86 6.91 6.84 6.35 THYRO1000187 2.7 3.58 5.3 4.92 6.24 5.22 THYRO1000190 1.12 3.32 2.94 3.73 4.55 2.71 THYRO1000196 0.3 5.28 0.81 0.66 1.21 0.52 THYRO1000197 2.05 7.28 4.69 4.08 6.24 3.89 THYRO1000199 0.76 6.28 4.13 1.93 2.08 1.98 THYRO1000206 8.47 6.92 9.25 8.44 11.6 7.5 THYRO1000221 1.9 3.17 4.42 4.02 5.87 4.54 THYRO1000222 3.65 4.26 4.23 4.68 4.96 4.93 * + THYRO1000228 0.81 3.67 2.85 2.24 3.04 2.94 THYRO1000241 1.76 3.7 6.29 4.62 5.54 4.01 THYRO1000242 0.63 4.16 4.46 2.49 2.56 2.62 THYRO1000246 1.61 5.5 3.9 3.43 4.7 3.91 THYRO1000253 1.07 4.05 1.73 1.99 3.35 2.31 THYRO1000270 1.15 5.12 1.39 1.22 2.5 1.26 THYRO1000279 0.42 2.84 0.25 0.65 1.01 0.58 THYRO1000285 2.75 4.65 7.31 7.03 7.75 4.88 THYRO1000288 7.76 7.59 11.77 5.68 5.07 7.22 THYRO1000296 4.18 6.04 6.22 7.4 11.24 8.96 * + THYRO1000320 1.54 5.83 4.97 3.65 4.45 3.34 THYRO1000322 1.1 5.48 2.48 1.76 3.93 1.76 THYRO1000327 1.75 7.69 4.77 6.21 5.23 4.41 THYRO1000343 2.5 6.12 5.35 5.06 5.04 6.13 THYRO1000345 1.36 7.34 11.92 7.82 5.84 9.49 THYRO1000358 1.82 3.39 3.08 1.92 2.32 1.54 THYRO1000368 0.76 2.39 2.73 1.43 2.82 0.58 THYRO1000375 3.2 7.03 4.79 7.38 6.09 9.77 THYRO1000381 0.92 2.88 2.19 3.87 3.11 2.74 THYRO1000387 0.98 6.66 3.22 2.53 3.56 2.51 THYRO1000394 1.31 9.88 4.59 4.29 5.19 2.61 THYRO1000395 0.8 10.44 2.26 1.97 2.07 2.02 THYRO1000400 0.57 8.1 2.82 2.35 2.96 2.52 THYRO1000401 0.86 1.94 2.5 1.87 1.16 1.57 THYRO1000407 1.97 2.3 1.36 1.37 1.58 0.55 THYRO1000420 1.8 2.67 4.46 3.52 3.53 3.39 THYRO1000438 1.78 4.37 3.26 2.94 3.33 3.15 THYRO1000452 2.62 7.99 6.45 3.71 5.75 4.38 THYRO1000455 0.32 6.67 2.31 0.25 0.97 0.87 THYRO1000471 0.99 8.03 2.05 1.11 2.08 1.02 THYRO1000481 1.33 6.23 4.68 3.79 3.45 4.55 THYRO1000484 1.2 1.42 2.41 2.35 3 2.21 THYRO1000488 1.18 2.64 2.44 1.49 2.02 1.7 THYRO1000501 1.12 4.01 2.78 3 1.92 1.82 THYRO1000502 0.34 3.7 1.69 1.79 1.44 1.2 THYRO1000505 0.13 4.64 1.19 1.14 1.02 0.6 THYRO1000535 11.1 20.54 39.24 54.13 69.59 62.96 * + THYRO1000556 1.89 6.36 4.13 3.77 5.17 3.69 THYRO1000558 0.25 2.82 1.12 1.16 0.81 0.61 THYRO1000569 2.88 4.12 6.05 5.78 4.46 4.88 THYRO1000570 2.31 3.28 8.46 8.53 6.04 3.49 THYRO1000572 0.43 2.04 1.11 0.17 0.97 -0.42 THYRO1000573 0.69 4.02 1.73 2.02 2.2 1.78 THYRO1000577 1.06 5 1.34 0.96 1.22 0.71 THYRO1000580 0.79 3.72 3.01 2.82 2.2 1.79 THYRO1000584 2.18 6.88 8.8 7.57 6.61 7.58 THYRO1000585 4.83 9.37 9.83 5.76 6.27 9.52 THYRO1000596 0.22 0.93 1.19 0.44 1.36 0.21 THYRO1000602 2.08 2.95 4.01 4.05 4.65 4.97 THYRO1000605 0.37 3.01 0.98 2.13 2.14 1.56 THYRO1000615 1.02 3.62 1.24 1.55 1.36 1.29 THYRO1000625 0.71 5.48 2.28 2.46 2.9 1.78 THYRO1000636 3.67 5.65 6.9 6.53 7.84 6.67 THYRO1000637 0.91 3.96 1.71 1.18 2.03 1.54 THYRO1000641 0.38 4.19 2.49 1.36 1.67 1.64 THYRO1000657 2.99 3.69 5.42 7.67 12.28 3.86 THYRO1000658 2.68 3.62 5.39 5.4 5.55 6.09 THYRO1000662 1.1 3.19 2.09 2.42 2.69 1.66 THYRO1000666 0.57 3.19 2.28 1.63 1.48 1.43 THYRO1000676 1.37 4.53 2.01 1.75 1.83 1.56 THYRO1000678 0.52 5.86 0.99 1.29 1.4 0.53 THYRO1000684 0.95 4.98 2.94 1.92 2.65 1.47 THYRO1000694 2.08 6.64 4.65 2.8 2.48 3.59 THYRO1000699 2.98 2.14 5.55 4.86 7.08 7.12 THYRO1000712 1.88 4.25 5.9 6.25 6.75 7.78 THYRO1000715 5.74 5.67 27.37 21.74 28.63 16.99 THYRO1000716 0.92 3.26 3.2 1.88 1.78 1.35 THYRO1000717 1.58 5 4.36 2.98 4.63 1.91 THYRO1000723 0.6 4.54 1.6 0.55 1.06 0.85 THYRO1000734 -0.01 4.81 1.89 1.49 1.73 1.07 THYRO1000748 0.98 5.51 5.23 2.35 3.85 3.18 THYRO1000755 1.74 3.26 4.32 4.33 3.47 4.38 THYRO1000756 2.79 4.24 3.24 3.46 4.2 3.41 THYRO1000776 0.48 2.17 3.02 3.36 3.99 3.34 THYRO1000777 1.81 3.39 4.54 4.99 2.05 2.37 THYRO1000779 1.45 3.55 0.88 0.18 1.01 -0.26 THYRO1000782 3.92 10.13 12.52 10.76 15.05 14.05 THYRO1000783 0.12 5.51 1.2 1.11 1.41 0.92 THYRO1000786 6.65 9.54 19.71 15.74 7.92 13.7 THYRO1000787 0.23 1.88 1.67 1.31 1.54 0.78 THYRO1000792 1.51 3.13 2.29 3.09 3.13 2.11 THYRO1000793 0.11 3.13 0.84 1.51 1.86 1.16 THYRO1000795 1.23 6.03 3.54 2.76 3.1 3.05 THYRO1000796 0.6 7.73 2.44 2.26 2.95 1.66 THYRO1000798 1.89 5.82 2.51 2.59 3.57 3.53 THYRO1000800 9.26 17.2 24.74 17.74 20.68 21.06 THYRO1000805 0.49 3.04 1.08 0.72 2.66 1.38 THYRO1000815 2.54 3.49 9.48 7.61 5.47 7.87 THYRO1000829 5.55 7.83 10.57 3.78 8.32 10.01 THYRO1000835 0.96 3.2 1.93 1.07 2.36 1.8 THYRO1000843 1.09 11.48 3.56 3.69 4.41 3.62 THYRO1000846 0.76 5.71 1.32 2.67 1.62 1.26 THYRO1000852 1.59 6.02 5.63 2.8 4.7 3.32 THYRO1000855 3.14 5.02 6.63 9.03 15.1 10.07 * + THYRO1000865 1.86 4.3 11.97 10.01 11.47 8.95 THYRO1000866 7.47 6.29 12.66 4.49 7.87 6.01 THYRO1000881 5.62 7.3 10.93 15.65 26.64 29.58 * + THYRO1000894 0.33 3.95 1.36 1.75 1.48 1 THYRO1000895 0.58 4.43 1.42 1.62 1.46 0.82 THYRO1000916 1.22 5.49 3.43 2.43 3.13 2.29 THYRO1000917 16.19 25.26 34.11 30.37 37.42 35.89 THYRO1000926 0.78 3.13 1.27 1.76 1.57 0.82 THYRO1000934 0.08 3.1 1.34 0.43 1.38 1.46 THYRO1000951 0.52 2.46 1.26 2.33 2.11 1.9 THYRO1000952 2.25 3.81 6.01 2.38 2.53 2.24 THYRO1000956 0.06 2.55 1.81 1.16 1.5 0.87 THYRO1000960 0.5 6.72 2.89 1.85 2.79 1.48 THYRO1000961 1.67 7.77 3.56 4.73 5.26 4.64 THYRO1000964 0.42 11.59 0.76 1 1.27 1.06 THYRO1000971 1.82 9.9 3.56 3.29 3.33 2.19 THYRO1000974 2.87 8.83 7.53 9.87 11.79 8.71 THYRO1000975 1.5 2.19 3.8 4.02 3.68 3.68 THYRO1000983 6.42 8.31 11.63 12.67 8.49 7.12 THYRO1000984 2.4 2.83 3.03 3.29 2.98 3.26 THYRO1000988 1.36 4.14 3.23 3.48 3.68 2.67 THYRO1000991 1.22 4.71 2.05 1.76 2.22 3.2 THYRO1000999 0.87 9.64 3.26 1.96 3.14 2.26 THYRO1001003 2.97 8.43 4.42 3.1 4.52 3.56 THYRO1001015 0.6 6.29 2.04 2.22 1.79 1.66 THYRO1001016 1.73 2.26 3.34 2.06 1.85 1.24 THYRO1001022 0.9 1.86 0.86 1.68 1.25 1.41 THYRO1001031 4.65 3.97 4.55 5.03 7.03 6.16 THYRO1001033 1.18 3.34 2.46 2.86 3.45 2.02 THYRO1001062 1.21 5.4 4.14 2.9 4.31 2.62 THYRO1001063 0.5 8.74 2.38 2.37 2.09 2.84 THYRO1001071 0.12 7.45 0.88 1.33 0.68 0.76 THYRO1001080 2.56 6.75 5.11 4.96 4.31 4.78 THYRO1001093 0.77 1.63 3.24 5.11 1.74 1.5 THYRO1001100 0.52 1.89 2.05 1.89 1.21 0.78 THYRO1001102 2.61 3.6 5.7 4.4 4.95 6.93 THYRO1001104 3.67 6.54 6.55 8.77 8.01 11.18 THYRO1001109 1.81 6.02 2.68 3.06 2.58 1.99 THYRO1001113 11.41 17.42 32 21.81 26.65 18.72 THYRO1001120 1.65 6.22 5.27 4.78 5.8 3.72 THYRO1001121 1.57 4.28 4.19 3.92 2.72 3 THYRO1001128 1.64 2.77 5.86 3.52 3.19 5.09 THYRO1001133 1.14 3.02 7.23 6.54 4.54 4.12 THYRO1001134 2.97 4.78 1.63 3.14 2.83 1.38 THYRO1001142 0.3 2.69 0.63 1.3 1.71 0.22 THYRO1001173 8.37 12.87 7.72 11.14 9.92 10.62 THYRO1001175 3.26 6.63 5.51 3.46 4.62 3.52 THYRO1001177 1.36 5.85 5.93 4.66 7.27 7.97 THYRO1001189 2.74 6.93 11.42 7.84 7.27 9.94 THYRO1001194 1.05 2.62 4.96 4.89 4.57 2.31 THYRO1001204 2.17 3.58 4.27 4.03 4.74 4 THYRO1001205 5.76 10.65 20.23 18.54 19.57 20.9 THYRO1001213 1.21 4.69 4.44 3.12 3.21 2.33 THYRO1001224 3.59 8.25 6.37 9.92 12.69 10.55 * + THYRO1001237 2.82 6.25 4.99 3.61 4.53 4.46 THYRO1001242 9.74 11.65 19.04 20.02 19.98 20.46 THYRO1001258 2.08 5.45 3.58 3.33 2.05 2.66 THYRO1001262 0.86 2.64 3.38 2.36 3.61 2.69 THYRO1001266 0.15 2.39 1.02 0.97 1.64 0.66 THYRO1001271 1.85 4.12 4.12 2.46 2.77 2.97 THYRO1001287 7.3 8.3 39.26 30.14 43.68 26.2 THYRO1001290 0.38 3.25 1.14 1.15 1.35 0.36 THYRO1001291 0.96 7.17 4.38 4.31 4.97 3.5 THYRO1001297 3.05 8.04 6.14 6.85 7.47 9.18 THYRO1001302 1.72 5.59 5.17 3.8 3.71 3.5 THYRO1001313 1.61 2.33 2.91 2.91 2.62 1.48 THYRO1001320 1.76 2.52 5.31 5.07 5.74 4.83 THYRO1001321 2.25 2.65 4.3 2.48 4.23 4.23 THYRO1001322 1.34 3.93 3.34 1.75 2.67 2.01 THYRO1001327 1.29 6.01 4.18 1.4 3.89 2.49 THYRO1001336 1.89 6.84 6.72 4.62 4.43 4.18 THYRO1001347 0.43 4.12 3.35 1.85 2.81 0.65 THYRO1001358 2.57 5.74 4.52 4.3 5.75 5.1 THYRO1001363 0.8 2.15 1.52 2.09 2.24 2.28 THYRO1001365 0.86 3 1.6 2.19 2.6 1.96 THYRO1001374 1.85 4.45 12.86 9.4 13.01 6.21 THYRO1001401 1.76 5.33 4.89 5.39 7.86 6.29 THYRO1001403 1.26 5.15 3.22 3.22 4.42 3.94 THYRO1001405 6.99 12.5 10.86 6.69 8.56 10.63 THYRO1001406 15.73 14.87 27.69 21.36 22.77 21.36 THYRO1001411 4.49 5.46 10.08 8.93 12.44 8.12 THYRO1001420 11.55 15.25 47.52 42.01 44.49 49.87 THYRO1001426 3.42 5.56 8.83 9.32 12.77 11.18 THYRO1001430 6.97 6.54 10.84 11.13 11.7 13.81 THYRO1001434 0.68 5.19 2.11 2.08 4.23 1.73 THYRO1001456 1.74 6.05 2.63 2.89 2.66 2.4 THYRO1001457 1.71 4.72 2.04 2.95 4.7 2.67 THYRO1001458 0.95 5.44 6.11 6.13 9.17 7.23 THYRO1001459 4.54 5.07 9.42 7.18 9.87 14.21 THYRO1001471 0.91 2.07 1.93 2.36 2.91 1.64 THYRO1001478 0.58 3.09 1.34 0.95 2.61 2.75 THYRO1001480 5.4 10.53 13.62 14.79 15.94 15.57 THYRO1001481 2.95 8.64 7.24 4.91 7.76 7.13 THYRO1001487 1.36 5.51 3.52 4.1 2.67 3.48 THYRO1001495 2.06 5.57 5.43 5.06 9.4 7.55 THYRO1001498 5.39 8.08 13.42 11.59 16.38 19.6 THYRO1001510 1.67 2.88 1.59 1.65 2.57 3.35 THYRO1001512 26.7 26.97 110.28 56.03 90.95 68.54 THYRO1001519 5.92 7.77 11.05 8.91 5.75 10.38 THYRO1001522 2.02 4.7 5.79 4.15 4.69 5.51 THYRO1001523 1.83 4.92 3.73 4.38 4.07 4.26 THYRO1001526 26.21 28.22 44.73 34.28 47.64 46.52 THYRO1001529 1.64 5.27 2.8 2.32 2.42 2.98 THYRO1001534 1.41 4.01 4.96 5.1 5.9 4.54 THYRO1001537 7.4 5.17 12.33 5.97 7.42 7.23 THYRO1001541 2.14 3.88 8.27 7.76 8.7 6.73 THYRO1001545 1.26 3.84 2.9 4.95 3.57 3.16 THYRO1001559 4.52 6.34 8.04 9.06 10.5 10.54 * + THYRO1001563 9.49 14.06 15.89 10 15.49 22.09 THYRO1001570 2.01 8.2 3.85 4.25 5.17 3.41 THYRO1001573 1.15 5.77 2.22 1.47 2.87 2.67 THYRO1001584 2.47 8.54 8.38 5.14 7.81 7.29 THYRO1001593 4.27 5.67 11.17 9.5 10.93 9.52 THYRO1001595 3.14 4.53 7.06 5.97 6.35 7.29 THYRO1001596 4.71 5.48 7.44 6.45 5.86 2.51 THYRO1001602 1.49 3.26 3.52 4.95 5.22 3.41 THYRO1001605 1.58 4.48 3.22 3.2 3.43 2.42 THYRO1001608 1.87 9.45 5.1 5.04 8.23 4.7 THYRO1001617 6.06 13.68 11.47 9.75 10.87 9.61 THYRO1001634 1.87 9.08 3.46 2.93 5.59 2.05 THYRO1001637 3.51 3.13 9.65 8.72 7.94 9.07 THYRO1001641 2.57 3.73 5.09 4.03 3.08 2.94 THYRO1001656 1.59 2.94 4.16 2.82 5.36 2.33 THYRO1001658 22.34 29.19 40.11 34.98 33.16 42.01 THYRO1001661 1.4 5.83 2.31 2.93 3.31 2.05 THYRO1001671 0.67 7.36 2.68 1.89 1.34 1.8 THYRO1001672 1.1 9.24 2.1 1.14 1.52 1.66 THYRO1001673 1.59 7.6 3.49 2.86 4.74 2.16 THYRO1001677 1.6 2.27 3.87 3.03 3.54 3.36 THYRO1001683 12.71 17.66 29.06 24.4 15.4 16.72 THYRO1001700 1.39 2.52 2.67 2.09 1.58 1.37 THYRO1001702 11.83 15.98 16.19 15.63 14.35 14.29 THYRO1001703 1.63 6.74 4.25 4.72 3.27 4.21 THYRO1001706 1.7 6.47 3.01 2.96 5.6 3.53 THYRO1001721 1.84 5.66 3.2 2.73 6.37 2.77 THYRO1001725 5.3 6.55 9.69 8.97 8.65 8.29 THYRO1001730 17.72 20.4 40.1 30.61 26.56 34.8 THYRO1001738 1.35 3.18 4.65 3.52 2.82 1.78 THYRO1001743 0.19 2.13 1.85 1.8 1.64 1.06 THYRO1001745 0.47 2.88 1.55 1.05 1.2 1.27 THYRO1001746 1.9 6.25 4.04 6.12 4.01 3.88 THYRO1001770 15.49 20.38 35.39 41.65 44.42 40.17 * + THYRO1001772 1.12 4.88 3.64 4.78 4.24 3.06 THYRO1001778 3.89 6.68 9.89 14.67 13.47 14.25 * + THYRO1001793 3.85 3.77 9.43 10.3 10.42 4.92 THYRO1001796 1.35 2.28 2.28 3.45 4.22 3.24 * + THYRO1001800 1.82 2.99 2.75 4.17 5.12 2.09 THYRO1001803 3.42 6.03 5.21 4.31 4.14 3.42 THYRO1001809 1.6 4.26 3.4 5.9 4.23 3.39 THYRO1001817 8.69 18.33 24.88 22.11 22.77 25.27 THYRO1001819 4.68 8.46 9.01 7.84 10.46 6.77 THYRO1001828 21.89 24.53 104.32 106.68 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18.52 19.25 98.18 77.47 116.12 61.1 Y79AA1000967 8.62 8.82 33.82 34.47 40.36 29.3 Y79AA1000968 3.32 5.67 6.89 8.86 9.4 7.96 * + Y79AA1000969 0.91 3.18 3.04 2.66 2.91 1.41 Y79AA1000976 1.43 4.72 3.02 2.55 3.51 1.43 Y79AA1000978 1.99 5.6 7.26 6.9 10.54 5.56 Y79AA1000985 9.39 12.84 40.49 38.26 44.3 27.89 Y79AA1000989 21.59 22.49 46.19 51.84 58.65 55.19 * + Y79AA1000991 22.11 22.21 110.42 72.46 96.96 82.23 Y79AA1001013 59.2 62.64 140.9 174.85 214.13 201.9 * + Y79AA1001014 2.27 4.16 4.1 4.8 5.2 6.55 Y79AA1001019 3.37 5.89 7.74 9.24 9.02 9.43 * + Y79AA1001020 5.37 7.82 9.43 12.31 11.11 10.86 * + Y79AA1001023 0.83 6.11 2.29 1.22 1.95 1.54 Y79AA1001030 4.23 8.79 10.87 11.14 10.72 12.43 Y79AA1001035 0.19 2.88 0.03 14.44 8.19 17.16 * + Y79AA1001041 1.78 2.46 2.36 2.93 2.45 2.78 Y79AA1001043 11.65 12.62 15.22 8.64 12.01 14.71 Y79AA1001048 1.1 4.78 3.73 4.05 4.52 4.21 Y79AA1001056 4.56 7.82 11.04 8.27 7.11 9.94 Y79AA1001061 1.53 7.79 5.28 6.13 7.46 6.66 Y79AA1001062 2.62 6.14 5.02 4.44 6.01 4.67 Y79AA1001068 3.46 6.39 7.29 6.61 8.69 7.05 Y79AA1001073 8.19 13.08 17.46 24.14 22.1 29.81 * + Y79AA1001077 7.1 7.08 17.15 14.69 14.74 17.08 Y79AA1001078 3.11 8.34 11.07 5.01 12.15 12.92 Y79AA1001081 3.59 5.61 4.94 9.62 9.98 10.5 ** + Y79AA1001088 27.75 38.61 69.33 93.1 88.97 113.04 * + Y79AA1001089 4.64 7.8 11.92 22.67 22.6 27.73 ** + Y79AA1001090 1.38 4.15 2.2 3.58 2.83 2.35 Y79AA1001105 3.7 5.23 15.81 12.52 22.1 13.35 Y79AA1001142 8.53 13.38 15.85 14.28 11.42 22.32 Y79AA1001145 2.22 4.68 5.13 4.97 6.26 5.87 Y79AA1001162 2.27 2.91 1.62 1.62 4.56 4 Y79AA1001167 0.86 2.76 2.38 1.12 2.35 0.77 Y79AA1001176 0.57 3.33 1.14 2.02 1.68 0.88 Y79AA1001177 1.21 5.5 2.22 2.35 3.01 1.99 Y79AA1001179 6.81 8.66 16.73 22.82 22.64 20.07 * + Y79AA1001185 1.33 5.3 4.55 3.65 4.49 5.8 Y79AA1001201 5.69 11.3 16.13 14.57 15.21 19.38 Y79AA1001205 1.87 3.28 2.85 5.87 4.85 4.09 * + Y79AA1001211 1.64 4.75 6.93 4.83 4.36 4.15 Y79AA1001212 3.55 6.93 15.91 13.74 15 11.65 Y79AA1001216 52.59 51.46 93.73 76.52 97.53 109.55 Y79AA1001228 6.1 11.21 9.34 8.99 12.19 10.24 Y79AA1001233 0.68 11.46 2.39 0.92 1.66 1.09 Y79AA1001236 4.46 12.86 9.25 11.4 10.66 13.08 Y79AA1001239 4.62 13.93 9.94 11.53 12.15 12.94 Y79AA1001240 8.74 8.6 13.75 9.13 6.68 3.01 Y79AA1001255 10.37 12.22 22.61 12.47 7.51 6.57 Y79AA1001264 3.63 5.15 4.49 7.73 8.59 8.75 ** + Y79AA1001272 10.81 13.63 17.47 21.56 20.67 21.32 * + Y79AA1001281 0.45 4.95 1.89 1.42 1.81 0.95 Y79AA1001299 2.49 11.34 9.06 9.9 9.26 9.81 Y79AA1001312 2.49 10.36 5.17 2.15 4.77 4.14 Y79AA1001319 3.34 11.88 5.27 7.23 6.05 7.15 Y79AA1001323 1.22 1.16 2.09 1.11 1.55 0.89 Y79AA1001328 2.04 3.18 3.62 4.66 4.48 4.05 * + Y79AA1001343 154.19 151.55 345.05 304.88 394.54 265.65 Y79AA1001351 0.81 2.77 1.67 0.03 1.26 0.96 Y79AA1001364 1.65 6.07 4.03 3.39 4.43 3.6 Y79AA1001367 2.16 7.41 2.93 3.09 5.34 3.19 Y79AA1001384 0.5 5.14 1.98 0.73 1.15 0.94 Y79AA1001391 0.59 3.73 2.88 1.35 1.65 1.2 Y79AA1001394 3.12 4.66 12.92 10.94 9.56 10.94 Y79AA1001402 2.77 3.7 5.95 5.65 5.09 4.14 Y79AA1001410 0.82 2.78 2.33 2.06 2.31 2.25 Y79AA1001414 2.76 7.5 7.59 11.08 10.73 10.06 * + Y79AA1001426 0.61 4.36 2.61 1.5 1.43 1.82 Y79AA1001427 14.22 13.44 86.36 59.92 88.36 63.53 Y79AA1001430 11.28 16.98 20.98 29.04 34.03 34.38 ** + Y79AA1001439 16.22 21.53 33.42 45.02 43.74 43.1 * + Y79AA1001485 1.65 2.51 4.38 4.85 3.88 3.57 Y79AA1001493 1.29 2.3 3.43 2.43 2.35 2.46 Y79AA1001511 4.79 8.57 11.05 9.39 9.11 6.47 Y79AA1001523 2.64 6.57 5.08 8.74 7.37 6.1 Y79AA1001530 7.46 11.69 22 41.43 36.37 36.07 ** + Y79AA1001532 5.12 7.35 6.69 10.49 14.82 12.9 * + Y79AA1001533 1.84 4.89 2.53 4.15 4 4.19 Y79AA1001541 2.82 5.89 7.54 7.23 5.08 7.34 Y79AA1001548 4.25 4.84 9.82 10.46 7.37 7.1 Y79AA1001555 2 2.55 3.65 4.7 5.28 4.25 * + Y79AA1001562 7.76 10.11 17.15 14.07 16.16 10.83 Y79AA1001581 2 5.05 4.47 5.1 7.01 3.54 Y79AA1001585 3.18 7.38 10.96 9.72 10.93 8.05 Y79AA1001592 2.61 7.38 5.97 8.15 8 7.02 Y79AA1001594 0.76 4.73 3.85 1.96 3.24 1.73 Y79AA1001603 56.74 70.81 153.14 131.56 112.16 107.66 Y79AA1001613 3.74 3.52 14.81 13.12 15.36 10.66 Y79AA1001630 0.71 2.36 1.73 1.14 2.64 0.67 Y79AA1001647 1.96 3.57 2.47 4.14 4.32 2.65 Y79AA1001664 4.67 8.39 11.43 8.96 10.01 8.73 Y79AA1001665 1.39 6.4 3.73 4.67 4.71 3.75 Y79AA1001679 8.92 15.94 20.71 20.53 26.67 25.35 Y79AA1001692 1.87 5.55 3.95 3.99 3.95 3.51 Y79AA1001696 1.97 6.49 2.77 1.83 2.63 2.55 Y79AA1001705 6.09 6.44 10.39 7.62 7.92 7.85 Y79AA1001711 16.17 12.34 29.74 13.73 23.83 21 Y79AA1001717 0.72 2.99 1.29 1.68 3.13 1.14 Y79AA1001719 2.5 5.79 6.44 6.15 6.07 6.43 Y79AA1001727 6.87 12.13 14.99 8.73 14.71 8.77 Y79AA1001750 10.21 13.63 21.67 21.92 32.29 24.33 Y79AA1001760 25.24 27.31 122.97 113.56 155.17 83.24 Y79AA1001777 1.17 3.59 1.6 2.49 1.75 1.28 Y79AA1001781 0.31 2.3 0.42 1.62 1.84 1.42 Y79AA1001787 1 3.94 3.54 5.51 5.18 5.15 Y79AA1001793 16.23 15.19 91.7 60.44 87.21 75.35 Y79AA1001795 1.23 3.84 2.24 2.05 2.45 2.8 Y79AA1001799 4.9 8.35 6.99 10.7 10.72 11.26 * + Y79AA1001800 2.25 8.3 10.1 8.49 10.51 9.9 Y79AA1001801 1.77 6.44 4.87 7.67 5.91 7.33 Y79AA1001803 0.74 2.15 1.72 1.85 1.68 1.17 Y79AA1001805 6.05 6.88 12.15 10.21 8.32 11.15 Y79AA1001807 3.37 6.33 12.56 11.76 17.8 16.79 Y79AA1001827 1.7 4.41 3.12 3.43 3.6 2.52 Y79AA1001846 1.82 6.52 5.51 6.52 5.09 5.07 Y79AA1001848 0.86 5.57 2.75 5.98 4.78 5.14 Y79AA1001853 1.38 6.16 2.76 3.24 4.56 3.63 Y79AA1001863 0.86 5 2.53 2.93 3.83 3.85 Y79AA1001866 2.29 3.2 5.81 3.53 3.98 3.46 Y79AA1001874 0.12 2.18 -0.21 1.17 0.75 0.51 Y79AA1001875 9.33 12.67 13.09 11.05 17.79 18.63 Y79AA1001907 68.02 70.94 96.4 118.34 86.75 104.86 Y79AA1001908 0.64 8.4 2.29 1.92 2.59 2.31 Y79AA1001923 1.61 6.64 3.03 3.86 3.76 3.35 Y79AA1001927 19.1 22.05 36.94 42.46 45.29 48.81 * + Y79AA1001930 4.07 6.65 8.07 7.92 12.42 12.21 Y79AA1001932 2.84 4.41 8.47 11.51 9.1 8.57 Y79AA1001933 2.14 3.27 3.69 4.34 7.99 6.65 * + Y79AA1001942 1.58 3.45 2.69 2.94 2.13 2.41 Y79AA1001963 9.6 9.37 46.06 38.48 49.64 47.27 Y79AA1001968 18.61 27.73 37.44 42.93 44.16 55.23 * + Y79AA1001983 1.81 6.35 4.28 3.97 5.86 4.47 Y79AA1002000 2.55 5.35 4.55 4.42 3.21 2.83 Y79AA1002004 13.1 18.87 27.47 23.72 29.45 40.93 Y79AA1002008 2.51 3.73 3.79 4.54 2.19 2.85 Y79AA1002012 1.37 3.22 2.81 3.22 2.29 2.87 Y79AA1002017 1.34 2.53 2.46 3.51 3.07 2.82 Y79AA1002022 2.99 4.94 5.93 7.32 7.51 6.01 Y79AA1002027 2.02 6.33 2.67 2.69 4.03 4.09 Y79AA1002050 2.53 8.12 4.22 6.68 6.91 5.11 Y79AA1002058 13.69 21.8 70.12 59.07 70.89 55.33 Y79AA1002060 6.38 13.17 20.54 17.14 21.12 24.23 Y79AA1002062 4.33 5.18 8.15 8.54 6.66 5.51 Y79AA1002065 33.54 39.97 72.6 49.46 30.04 41.81 Y79AA1002067 10.11 11.64 17.24 16.25 9.42 8.13 Y79AA1002069 0.97 1.79 0.54 1.55 1.44 0.66 Y79AA1002070 10.16 33.47 44.36 52.16 71.15 73.35 * + Y79AA1002074 38.55 74.38 179.6 165.55 282.48 224.96 Y79AA1002076 0.48 9.71 2.89 2.86 3.34 1.91 Y79AA1002083 1.2 7.48 2.03 2.73 1.75 2.06 Y79AA1002084 1.79 2.59 4.54 3.73 3.73 2.98 Y79AA1002086 0.96 1.78 1.71 2.77 1.88 1.43 Y79AA1002087 11.18 14.9 27.67 33.34 30.01 23.08 Y79AA1002089 1.18 3.46 2.13 1.46 2.92 3.26 Y79AA1002093 2.19 5.48 5.25 5.28 5.68 6.17 Y79AA1002101 1.11 8.58 2.98 6.54 5.58 6.6 Y79AA1002103 1.47 10.22 3.39 4.43 6.49 4.7 Y79AA1002115 4.34 9.78 7.37 7.45 7.03 6.95 Y79AA1002121 1.55 2.16 2.18 1.67 2.55 2.31 Y79AA1002125 6.67 7.08 9.29 8.81 6.4 7.6 Y79AA1002129 1.64 6.23 7.84 5.41 2.2 4.93 Y79AA1002131 0.9 3.25 0.78 0.77 1.29 1.15 Y79AA1002139 0.69 5.02 1.04 1.83 1.53 1.34 Y79AA1002144 25.99 29.62 51.01 42.61 51.16 43.17 Y79AA1002177 1.72 5.97 4.33 4.79 3.09 4.73 Y79AA1002183 10.44 13.89 17.69 27.61 29.67 28.92 ** + Y79AA1002202 3.97 7.15 8.34 18.27 10.12 17.85 * + Y79AA1002204 0.53 0.99 1.56 1.7 2.2 1.54 Y79AA1002206 2.63 5.36 7.28 4.35 2.95 1.49 Y79AA1002208 4.26 6.54 3.94 6.88 6.3 3.96 Y79AA1002209 1.8 6.34 2.88 4.38 3.74 4.57 Y79AA1002210 0.41 4.14 2.09 1.8 2.24 1.65 Y79AA1002211 2.25 5.39 3.85 5.71 5.3 4.5 Y79AA1002213 1.15 4.13 6.53 7.38 7.54 7.43 Y79AA1002215 18.7 18.69 26.61 17.72 15.59 9.62 Y79AA1002220 3.78 3.38 2.87 4.89 4.19 4.14 * + Y79AA1002226 8.54 8.9 9.75 13.06 14.2 4.41 Y79AA1002229 1.35 3.88 3.38 2.95 2.79 2.67 Y79AA1002234 3.24 6.82 3.94 4.29 7.74 6.88 Y79AA1002235 5.6 7.55 6.43 8.78 9.74 9.47 * + Y79AA1002246 0.59 5.06 2.41 3.94 2.54 4.27 Y79AA1002258 0.72 7.26 2.92 3.99 4.19 2.7 Y79AA1002279 17.79 19.12 27.8 16.52 19.13 11.5 Y79AA1002292 1.68 2.1 3.22 2.96 3.91 2.73 Y79AA1002298 0.76 2.52 1.32 2.03 2.77 1.06 Y79AA1002307 1.05 4.35 1.79 0.76 1.05 1.2 Y79AA1002309 1.15 4.19 2.3 2.21 1.78 2.55 Y79AA1002311 2.84 7.35 3.43 5.71 6.04 5.45 Y79AA1002334 1.72 6.54 2.95 4.77 4.19 3.35 Y79AA1002351 1.27 5.5 2.89 3.5 3.38 3.06 Y79AA1002355 12.83 12.25 28.96 22.94 22.07 21.02 Y79AA1002361 2.22 2.27 3.26 2.47 4.54 1.55 Y79AA1002365 0.66 2.04 2.26 1.97 3.51 2.25 Y79AA1002373 1.17 3.93 2.42 1.59 1.97 1.43 Y79AA1002376 110.81 135.82 249.8 205.99 213.25 191.69 Y79AA1002378 1.9 4.8 4.91 2.2 3.6 3 Y79AA1002381 8.65 14.11 19.19 18.84 21.52 17.97 Y79AA1002388 7.05 9.99 18.24 15.88 21.51 19.99 Y79AA1002399 1.79 4.25 3.74 4.62 4.08 3.47 Y79AA1002407 3.05 4.16 3.13 4.66 5.77 4.5 * + Y79AA1002413 3.21 6.78 8.05 6.46 8.32 6.87 Y79AA1002416 1.46 5 2.74 2.49 3.44 3.55 Y79AA1002429 5.5 8.15 7.27 8 11.11 8.01 Y79AA1002431 0.92 4.43 0.48 0.79 1.78 0.89 Y79AA1002433 1.27 5.9 3.24 4.8 3.84 5.58 Y79AA1002445 4.01 5.34 5.76 3.1 4.89 5.41 Y79AA1002461 0.63 2.45 1.79 1.19 2.71 1.41 Y79AA1002466 39.02 70.71 94.5 91.12 82.27 94.71 Y79AA1002471 4.44 6.67 6.08 7.43 8.06 10.49 Y79AA1002472 2.41 6.16 5.99 6.8 8.39 4.06 Y79AA1002474 1.93 8.27 4.31 4.89 6.52 7.13 Y79AA1002482 3.52 6.66 10.37 9.02 11.81 8.69 Y79AA1002487 1.38 4.12 2.46 1.96 3.01 2.56 Y79AA1002490 10.37 9.91 16.35 11.11 12.88 16.86 Y79AA1002493 1.96 4.07 6.14 6.5 8.9 4.1 ZRV6C1006278 0.61 4.08 2.22 1.81 1.58 2.11 ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

【０４５２】

【発明の効果】本発明により、１７３種の新規な蛋白質
と、それをコードするポリヌクレオチドが提供された。
全長cDNAの分離が進んでいないヒトにおいて、新規な全
長cDNAを提供した意義は大きい。本発明によって提供さ
れる、分泌蛋白質や膜蛋白質は、多くの疾患に関連した
蛋白質であることがわかっている。疾患に関連した遺伝
子や蛋白質は、診断マーカー、発現や活性を制御する医
薬品の開発、あるいは遺伝子治療のターゲットになるな
ど医薬品の開発等に有効である。中でも、分泌蛋白質を
コードするcDNAは、蛋白質自身に医薬品としての有用性
が期待できること、および多くの疾患に関連する遺伝子
を含む可能性があることから、本発明によって提供され
たこれらのcDNAは、産業上きわめて重要である。さら
に、膜蛋白質やそれをコードする遺伝子についても、疾
患の指標となること等が期待できる。これらのcDNAも、
産業上きわめて重要であり、コードする蛋白質の持つ活
性の制御や、発現の制御を通じて疾患の治療効果をもた
らすこと等が期待される。

【０４５３】

【配列表】 SEQUENCE LISTING <110> Helix Research Institute <120> Secrete, or Membrane Proteins. <130> H1-106DP4 <140> <141> <150> JP 1999-194179 <151> 1999-07-08 <150> US 60/159586 <151> 1999-10-18 <150> JP 2000-118775 <151> 2000-01-11 <150> US 60/183323 <151> 2000-02-17 <150> JP 2000-183766 <151> 2000-05-02 <160> 679 <170> PatentIn Ver. 2.0 <210> 1 <211> 1992 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (192)..(869) <400> 1 cgaagggtac cgacccggca gaagctcgga gctctcgggg tatcgaggag gcaggcccgc 60 gggcgcacgg gcgagcgggc cgggagccgg agcggcggag gagccggcag cagcggcgcg 120 gcgggctcca ggcgaggcgg tcgacgctcc tgaaaacttg cgcgcacgct cgcgccactg 180 cgcccggagc g atg aag atg gtc gcg ccc tgg acg cgg ttc tac tcc aac 230 Met Lys Met Val Ala Pro Trp Thr Arg Phe Tyr Ser Asn 1 5 10 agc tgc tgc ttg tgc tgc cat gtc cgc acc ggc acc atc ctg ctc ggc 278 Ser Cys Cys Leu Cys Cys His Val Arg Thr Gly Thr Ile Leu Leu Gly 15 20 25 gtc tgg tat ctg atc atc aat gct gtg gta ctg ttg att tta ttg agt 326 Val Trp Tyr Leu Ile Ile Asn Ala Val Val Leu Leu Ile Leu Leu Ser 30 35 40 45 gcc ctg gct gat ccg gat cag tat aac ttt tca agt tct gaa ctg gga 374 Ala Leu Ala Asp Pro Asp Gln Tyr Asn Phe Ser Ser Ser Glu Leu Gly 50 55 60 ggt gac ttt gag ttc atg gat gat gcc aac atg tgc att gcc att gcg 422 Gly Asp Phe Glu Phe Met Asp Asp Ala Asn Met Cys Ile Ala Ile Ala 65 70 75 att tct ctt ctc atg atc ctg ata tgt gct atg gct act tac gga gcg 470 Ile Ser Leu Leu Met Ile Leu Ile Cys Ala Met Ala Thr Tyr Gly Ala 80 85 90 tac aag caa cgc gca gcc tgg atc atc cca ttc ttc tgt tac cag atc 518 Tyr Lys Gln Arg Ala Ala Trp Ile Ile Pro Phe Phe Cys Tyr Gln Ile 95 100 105 ttt gac ttt gcc ctg aac atg ttg gtt gca atc act gtg ctt att tat 566 Phe Asp Phe Ala Leu Asn Met Leu Val Ala Ile Thr Val Leu Ile Tyr 110 115 120 125 cca aac tcc att cag gaa tac ata cgg caa ctg cct cct aat ttt ccc 614 Pro Asn Ser Ile Gln Glu Tyr Ile Arg Gln Leu Pro Pro Asn Phe Pro 130 135 140 tac aga gat gat gtc atg tca gtg aat cct acc tgt ttg gtc ctt att 662 Tyr Arg Asp Asp Val Met Ser Val Asn Pro Thr Cys Leu Val Leu Ile 145 150 155 att ctt ctg ttt att agc att atc ttg act ttt aag ggt tac ttg att 710 Ile Leu Leu Phe Ile Ser Ile Ile Leu Thr Phe Lys Gly Tyr Leu Ile 160 165 170 agc tgt gtt tgg aac tgc tac cga tac atc aat ggt agg aac tcc tct 758 Ser Cys Val Trp Asn Cys Tyr Arg Tyr Ile Asn Gly Arg Asn Ser Ser 175 180 185 gat gtc ctg gtt tat gtt acc agc aat gac act acg gtg ctg cta ccc 806 Asp Val Leu Val Tyr Val Thr Ser Asn Asp Thr Thr Val Leu Leu Pro 190 195 200 205 ccg tat gat gat gcc act gtg aat ggt gct gcc aag gag cca ccg cca 854 Pro Tyr Asp Asp Ala Thr Val Asn Gly Ala Ala Lys Glu Pro Pro Pro 210 215 220 cct tac gtg tct gcc taagccttca agtgggcgga gctgagggca gcagcttgac 909 Pro Tyr Val Ser Ala 225 tttgcagaca tctgagcaat agttctgtta tttcactttt gccatgagcc tctctgagct 969 tgtttgttgc tgaaatgcta ctttttaaaa tttagatgtt agattgaaaa ctgtagtttt 1029 caacatatgc tttgctagaa cactgtgata gattaactgt agaattcttc ctgtacgatt 1089 ggggatataa cgggcttcac taaccttccc taggcattga aacttccccc aaatctgatg 1149 gacctagaag tctgcttttg tacctgctgg gccccaaagt tgggcatttt tctctctgtt 1209 ccctctcttt tgaaaatgta aaataaaacc aaaaatagac aactttttct tcagccattc 1269 cagcatagag aacaaaacct tatggaaaca ggaatgtcaa ttgtgtaatc attgttctaa 1329 ttaggtaaat agaagtcctt atgtatgtgt tacaagaatt tcccccacaa catcctttat 1389 gactgaagtt caatgacagt ttgtgtttgg tggtaaagga ttttctccat ggcctgaatt 1449 aagaccatta gaaagcacca ggccgtggga gcagtgacca tctgctgact gttcttgtgg 1509 atcttgtgtc cagggacatg gggtgacatg cctcgtatgt gttagagggt ggaatggatg 1569 tgtttggcgc tgcatgggat ctggtgcccc tcttctcctg gattcacatc cccacccagg 1629 gcccgctttt actaagtgtt ctgccctaga ttggttcaag gaggtcatcc aactgacttt 1689 atcaagtgga attgggatat atttgatata cttctgccta acaacatgga aaagggtttt 1749 cttttccctg caagctacat cctactgctt tgaacttcca agtatgtcta gtcacctttt 1809 aaaatgtaaa cattttcaga aaaatgagga ttgccttcct tgtatgcgct ttttaccttg 1869 actacctgaa ttgcaaggga tttttatata ttcatatgtt acaaagtcag caactctcct 1929 gttggttcat tattgaatgt gctgtaaatt aagtcgtttg caattaaaac aaggtttgcc 1989 cac 1992 <210> 2 <211> 226 <212> PRT <213> Homo sapiens <400> 2 Met Lys Met Val Ala Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys 1 5 10 15 Leu Cys Cys His Val Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr 20 25 30 Leu Ile Ile Asn Ala Val Val Leu Leu Ile Leu Leu Ser Ala Leu Ala 35 40 45 Asp Pro Asp Gln Tyr Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe 50 55 60 Glu Phe Met Asp Asp Ala Asn Met Cys Ile Ala Ile Ala Ile Ser Leu 65 70 75 80 Leu Met Ile Leu Ile Cys Ala Met Ala Thr Tyr Gly Ala Tyr Lys Gln 85 90 95 Arg Ala Ala Trp Ile Ile Pro Phe Phe Cys Tyr Gln Ile Phe Asp Phe 100 105 110 Ala Leu Asn Met Leu Val Ala Ile Thr Val Leu Ile Tyr Pro Asn Ser 115 120 125 Ile Gln Glu Tyr Ile Arg Gln Leu Pro Pro Asn Phe Pro Tyr Arg Asp 130 135 140 Asp Val Met Ser Val Asn Pro Thr Cys Leu Val Leu Ile Ile Leu Leu 145 150 155 160 Phe Ile Ser Ile Ile Leu Thr Phe Lys Gly Tyr Leu Ile Ser Cys Val 165 170 175 Trp Asn Cys Tyr Arg Tyr Ile Asn Gly Arg Asn Ser Ser Asp Val Leu 180 185 190 Val Tyr Val Thr Ser Asn Asp Thr Thr Val Leu Leu Pro Pro Tyr Asp 195 200 205 Asp Ala Thr Val Asn Gly Ala Ala Lys Glu Pro Pro Pro Pro Tyr Val 210 215 220 Ser Ala 225 <210> 3 <211> 1883 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (124)..(1101) <400> 3 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 60 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 120 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 168 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1 5 10 15 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 216 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 20 25 30 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 264 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 35 40 45 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 312 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 50 55 60 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 360 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 65 70 75 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 408 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 80 85 90 95 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 456 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 100 105 110 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 504 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 115 120 125 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 552 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 130 135 140 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 600 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 145 150 155 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 648 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 160 165 170 175 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 696 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 180 185 190 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 744 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 195 200 205 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 792 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 210 215 220 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 840 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 225 230 235 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 888 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 240 245 250 255 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 936 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 260 265 270 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 984 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 275 280 285 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1032 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 290 295 300 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1080 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 305 310 315 nnn nnn nnn nnn nnn nnn nnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1131 nnn nnn nnn nnn nnn nnn nnn 320 325 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1191 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1251 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1311 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1371 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1431 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1491 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1551 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1611 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1671 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1731 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1791 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1851 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn 1883 <210> 4 <211> 326 <212> PRT <213> Homo sapiens <400> 4 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1 5 10 15 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 20 25 30 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 35 40 45 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 50 55 60 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 65 70 75 80 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 85 90 95 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 100 105 110 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 115 120 125 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 130 135 140 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 145 150 155 160 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 165 170 175 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 180 185 190 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 195 200 205 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 210 215 220 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 225 230 235 240 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 245 250 255 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 260 265 270 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 275 280 285 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 290 295 300 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 305 310 315 320 nnn nnn nnn nnn nnn nnn 325 <210> 5 <211> 1366 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (59)..(718) <400> 5 acactcggcc taggaatttc ccttatctcc ttcgcagtgc agctccttca acctcgcc 58 atg gcc tct gcc gga atg cag atc ctg gga gtc gtc ctg aca ctg ctg 106 Met Ala Ser Ala Gly Met Gln Ile Leu Gly Val Val Leu Thr Leu Leu 1 5 10 15 ggc tgg gtg aat ggc ctg gtc tcc tgt gcc ctg ccc atg tgg aag gtg 154 Gly Trp Val Asn Gly Leu Val Ser Cys Ala Leu Pro Met Trp Lys Val 20 25 30 acc gct ttc atc ggc aac agc atc gtg gtg gcc cag gtg gtg tgg gag 202 Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 35 40 45 ggc ctg tgg atg tcc tgc gtg gtg cag agc acc ggc cag atg cag tgc 250 Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 50 55 60 aag gtg tac gac tca ctg ctg gcg ctg cca cag gac ctg cag gct gca 298 Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 65 70 75 80 cgt gcc ctc tgt gtc atc gcc ctc ctt gtg gcc ctg ttc ggc ttg ctg 346 Arg Ala Leu Cys Val Ile Ala Leu Leu Val Ala Leu Phe Gly Leu Leu 85 90 95 gtc tac ctt gct ggg gcc aag tgt acc acc tgt gtg gag gag aag gat 394 Val Tyr Leu Ala Gly Ala Lys Cys Thr Thr Cys Val Glu Glu Lys Asp 100 105 110 tcc aag gcc cgc ctg gtg ctc acc tct ggg att gtc ttt gtc atc tca 442 Ser Lys Ala Arg Leu Val Leu Thr Ser Gly Ile Val Phe Val Ile Ser 115 120 125 ggg gtc ctg acg cta atc ccc gtg tgc tgg acg gcg cat gcc gtc atc 490 Gly Val Leu Thr Leu Ile Pro Val Cys Trp Thr Ala His Ala Val Ile 130 135 140 cgg gac ttc tat aac ccc ctg gtg gct gag gcc caa aag cgg gag ctg 538 Arg Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Gln Lys Arg Glu Leu 145 150 155 160 ggg gcc tcc ctc tac ttg ggc tgg gcg gcc tca ggc ctt ttg ttg ctg 586 Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 165 170 175 ggt ggg ggg ttg ctg tgc tgc act tgc ccc tcg ggg ggg tcc cag ggc 634 Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly 180 185 190 ccc agc cat tac atg gcc cgc tac tca aca tct gcc cct gcc atc tct 682 Pro Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser 195 200 205 cgg ggg ccc tct gag tac cct acc aag aat tac gtc tgacgtggag 728 Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 210 215 220 gggaatgggg gctccgtggc gctagagcca tccagaagtg gcagtgccca acagccttgg 788 gatgggttcg taccttttgt ttctgcctcc tgctattttt cttttgactg aggatattta 848 aaattcattt gaaaactgag ctaaggtgtt gactcagact ctcacttagg ctctgctgtt 908 tctcaccctt ggatgatgga gccaaagagg ggatgctttg agattctgga tcttgacatg 968 cccatcttag aagccagtca agctatggaa ctaatgcgga ggctgcttgc tgtgctggct 1028 ttgcaacaag acagactgtc cccaagagtt cctgctgctg ctgggggctg ggcttcccta 1088 gatgtcactg gacagctgcc ccccatccta ctcaggtctc tggagctcct ctcttcaccc 1148 ctggaaaaac aaatgatctg ttaacaaagg actgcccacc tccggaactt ctgacctctg 1208 tttcctccgt cctgataaga cgtccacccc ccagggccag gtcccagcta tgtagacccc 1268 cgcccccacc tccaacactg cacccttctg ccctgccccc ctcgtctcac cccctttaca 1328 ctcacatttt tatcaaataa agcatgtttt gttagtgc 1366 <210> 6 <211> 220 <212> PRT <213> Homo sapiens <400> 6 Met Ala Ser Ala Gly Met Gln Ile Leu Gly Val Val Leu Thr Leu Leu 1 5 10 15 Gly Trp Val Asn Gly Leu Val Ser Cys Ala Leu Pro Met Trp Lys Val 20 25 30 Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 35 40 45 Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 50 55 60 Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 65 70 75 80 Arg Ala Leu Cys Val Ile Ala Leu Leu Val Ala Leu Phe Gly Leu Leu 85 90 95 Val Tyr Leu Ala Gly Ala Lys Cys Thr Thr Cys Val Glu Glu Lys Asp 100 105 110 Ser Lys Ala Arg Leu Val Leu Thr Ser Gly Ile Val Phe Val Ile Ser 115 120 125 Gly Val Leu Thr Leu Ile Pro Val Cys Trp Thr Ala His Ala Val Ile 130 135 140 Arg Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Gln Lys Arg Glu Leu 145 150 155 160 Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 165 170 175 Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly 180 185 190 Pro Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser 195 200 205 Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 210 215 220 <210> 7 <211> 3425 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (135)..(1844) <400> 7 gagacggggt ggcggctgca gcccgggtag ggccaggaga cccggtccac gtttgcaaac 60 gcagccgaac gcccaggccg acccgtgccg cccgagcgcc gcgctgcgtc cgcgccactc 120 ttctcgccgc cccg atg gcg ttc cgg ggc tgg agg ccc ccg ccg cca ccg 170 Met Ala Phe Arg Gly Trp Arg Pro Pro Pro Pro Pro 1 5 10 ctg ctc ctg ctg ctg ctc tgg gtg acc ggg cag gca gcg ccc gtg gcg 218 Leu Leu Leu Leu Leu Leu Trp Val Thr Gly Gln Ala Ala Pro Val Ala 15 20 25 ggc ctg ggc tcc gac gcg gag ctg cag atc gag cgg cgc ttc gtg ccc 266 Gly Leu Gly Ser Asp Ala Glu Leu Gln Ile Glu Arg Arg Phe Val Pro 30 35 40 gac gag tgc ccg cgc acc gtg cgc agc ggc gac ttc gtg cgc tac cac 314 Asp Glu Cys Pro Arg Thr Val Arg Ser Gly Asp Phe Val Arg Tyr His 45 50 55 60 tac gtg ggg acg ttc ccc gac ggc cag aag ttc gac tcc agc tat gac 362 Tyr Val Gly Thr Phe Pro Asp Gly Gln Lys Phe Asp Ser Ser Tyr Asp 65 70 75 aga gac tcc act ttc aat gtg ttt gtg gga aaa gga cag ctg atc aca 410 Arg Asp Ser Thr Phe Asn Val Phe Val Gly Lys Gly Gln Leu Ile Thr 80 85 90 ggg atg gac cag gct ctt gtt ggg atg tgc gta aac gag aga cgt ttc 458 Gly Met Asp Gln Ala Leu Val Gly Met Cys Val Asn Glu Arg Arg Phe 95 100 105 gtg aag att ccc cca aag ctt gcc tac gga aat gaa gga gtt tct ggt 506 Val Lys Ile Pro Pro Lys Leu Ala Tyr Gly Asn Glu Gly Val Ser Gly 110 115 120 gtg atc ccc ccc aat tca gtg ctt cat ttt gat gta ctt ctg atg gat 554 Val Ile Pro Pro Asn Ser Val Leu His Phe Asp Val Leu Leu Met Asp 125 130 135 140 att tgg aat tct gaa gac cag gtt cag att cac acc tat ttc aag ccc 602 Ile Trp Asn Ser Glu Asp Gln Val Gln Ile His Thr Tyr Phe Lys Pro 145 150 155 ccg agt tgc cct cgg acc atc cag gtg tct gat ttt gtg agg tac cac 650 Pro Ser Cys Pro Arg Thr Ile Gln Val Ser Asp Phe Val Arg Tyr His 160 165 170 tac aac ggg acg ttc ctg gac gga act ctg ttt gat tcg agt cac aat 698 Tyr Asn Gly Thr Phe Leu Asp Gly Thr Leu Phe Asp Ser Ser His Asn 175 180 185 cgc atg aaa aca tat gac acg tat gtg gga att ggc tgg ctg att cct 746 Arg Met Lys Thr Tyr Asp Thr Tyr Val Gly Ile Gly Trp Leu Ile Pro 190 195 200 gga atg gat aaa ggg ctg ctg ggg atg tgt gtg ggt gag aag cgc atc 794 Gly Met Asp Lys Gly Leu Leu Gly Met Cys Val Gly Glu Lys Arg Ile 205 210 215 220 atc acc att cct cct ttt ctg gcc tat gga gag gat gga gat ggg aaa 842 Ile Thr Ile Pro Pro Phe Leu Ala Tyr Gly Glu Asp Gly Asp Gly Lys 225 230 235 gac att ccc ggt cag gca tct ctg gtg ttt gat gtt gca tta ttg gac 890 Asp Ile Pro Gly Gln Ala Ser Leu Val Phe Asp Val Ala Leu Leu Asp 240 245 250 ctc cat aac ccc aag gac agc att tcc att gag aac aag gta gta cct 938 Leu His Asn Pro Lys Asp Ser Ile Ser Ile Glu Asn Lys Val Val Pro 255 260 265 gaa aac tgt gag cgg ata agt caa agt ggg gac ttt ctc agg tat cat 986 Glu Asn Cys Glu Arg Ile Ser Gln Ser Gly Asp Phe Leu Arg Tyr His 270 275 280 tac aat ggc acg ctt ctg gat ggc acc ctc ttt gat tcc agc tac tct 1034 Tyr Asn Gly Thr Leu Leu Asp Gly Thr Leu Phe Asp Ser Ser Tyr Ser 285 290 295 300 cgg aac cgc acg ttt gac acg tac att ggg cag ggc tac gtg att cct 1082 Arg Asn Arg Thr Phe Asp Thr Tyr Ile Gly Gln Gly Tyr Val Ile Pro 305 310 315 ggg atg gat gaa ggt cta ctt ggt gtt tgc att gga gaa aag cga agg 1130 Gly Met Asp Glu Gly Leu Leu Gly Val Cys Ile Gly Glu Lys Arg Arg 320 325 330 att gtg gtc ccg cct cac ctg ggg tat gga gag gaa gga aga ggg aat 1178 Ile Val Val Pro Pro His Leu Gly Tyr Gly Glu Glu Gly Arg Gly Asn 335 340 345 atc ccc ggc tcg gct gtg ctg gtg ttt gac atc cat gtg atc gac ttc 1226 Ile Pro Gly Ser Ala Val Leu Val Phe Asp Ile His Val Ile Asp Phe 350 355 360 cac aac cct tcg gac tcc atc agc atc acc tcc cac tac aaa ccc cct 1274 His Asn Pro Ser Asp Ser Ile Ser Ile Thr Ser His Tyr Lys Pro Pro 365 370 375 380 gac tgc tca gtg ctg agt aag aag gga gat tac ctc aaa tat cac tac 1322 Asp Cys Ser Val Leu Ser Lys Lys Gly Asp Tyr Leu Lys Tyr His Tyr 385 390 395 aat gcc tca ctt ctg gat ggg acc ctg ctg gac tcc acg tgg aat tta 1370 Asn Ala Ser Leu Leu Asp Gly Thr Leu Leu Asp Ser Thr Trp Asn Leu 400 405 410 ggc aaa act tac aat att gtt ctg gga tct ggg caa gtt gtg ttg ggg 1418 Gly Lys Thr Tyr Asn Ile Val Leu Gly Ser Gly Gln Val Val Leu Gly 415 420 425 atg gac atg ggt ctc aga gag atg tgc gtt ggc gag aaa cgg aca gtg 1466 Met Asp Met Gly Leu Arg Glu Met Cys Val Gly Glu Lys Arg Thr Val 430 435 440 atc att ccg cct cac ctg ggc tat ggg gaa gct ggc gtg gat gga gaa 1514 Ile Ile Pro Pro His Leu Gly Tyr Gly Glu Ala Gly Val Asp Gly Glu 445 450 455 460 gtg ccc ggc agt gcc gta tta gtg ttt gac att gag ctg ccg gag ctg 1562 Val Pro Gly Ser Ala Val Leu Val Phe Asp Ile Glu Leu Pro Glu Leu 465 470 475 gtg gct ggc ctt cct gag ggg tac atg ttc ata tgg aat ggt gag gtg 1610 Val Ala Gly Leu Pro Glu Gly Tyr Met Phe Ile Trp Asn Gly Glu Val 480 485 490 tca ccc aac ctc ttt gaa gaa att gac aag gat ggc aac gga gaa gtc 1658 Ser Pro Asn Leu Phe Glu Glu Ile Asp Lys Asp Gly Asn Gly Glu Val 495 500 505 ctc ctg gaa gag ttc tca gag tac att cac gcc cag gtg gca tct ggc 1706 Leu Leu Glu Glu Phe Ser Glu Tyr Ile His Ala Gln Val Ala Ser Gly 510 515 520 aaa ggg aaa ctc gct cct ggc ttt gat gct gag ctg att gtg aag aat 1754 Lys Gly Lys Leu Ala Pro Gly Phe Asp Ala Glu Leu Ile Val Lys Asn 525 530 535 540 atg ttc acc aac cag gac cgg aat gga gat ggg aag gtc aca gcc gag 1802 Met Phe Thr Asn Gln Asp Arg Asn Gly Asp Gly Lys Val Thr Ala Glu 545 550 555 gaa ttt aaa ctc aaa gac cag gaa gcc aaa cac gat gaa ctc 1844 Glu Phe Lys Leu Lys Asp Gln Glu Ala Lys His Asp Glu Leu 560 565 570 taaacctggc atgaaccaga tggtgccagg gagtacgtga caccaagcca cctgtgtggc 1904 aagacgtgca gtgagggtgc aagggtctct cagaagttgc atcattagcc agtagtaggt 1964 gggtcacata gtacctggtg tacacaccgg ggtgggttga tatatggggt gagaagtttg 2024 ggctgatcgc cagtgatagt aaacaaaatc tgtgcagagg gccttagcat gggatgtgtc 2084 cagtattgaa aaggctgcac tgccaaccat gatttgtgag ccctctggga aattttgtta 2144 ttaaaggaat atatagtgtc agacagaagt tataatcgtc ttggaggaac cataagaaaa 2204 ggtgtccagg gtatctatat aaagagggtt aaattttttt ttaacttgct ggttaaaaca 2264 ttttagaaat attcttgaga tgggcaggag agtcaaaggg cttgcttgcc ccagcagagt 2324 tcccagcaga cagccatggc tcttcccagc agcctgtgca aattctgatg atggccccac 2384 ccccgcacac gcacacgcac atcatgcttt tccagctcat cacaccccgc cccactatgg 2444 gcctaccatt aatagtgtat aacttggagg ttaaaagagc cttttggaca gaaaactggg 2504 ccaggaaaag gcatctcaga ccacaaatag agaatttgat tcctcatttg ccacataagt 2564 catctgctta gcttttcctt tccttttttt tttttttttt tttctggagg cagagtctcc 2624 ctttgtcgcc aggctggagt gcagtggtgc catctcggct cactgcagca ctgtctcggc 2684 tcactgcagc ctccgcctcc cgtattcaag cgattctcct gtctcagcct cctgagtagc 2744 tgggactaca ggtgtgcacc accacgcccg gctaattttt gtatttttag tagagacggg 2804 gtttcactgt gttggccagg atggtctcaa tctcgacctc gtgatccgcc caccttggcc 2864 tcccaaagtg ttgggattac aggcgtgact caccatgccc agccacttag ttttttctta 2924 ttcccacctt tctatcccat agaacactct tttttatctt ccctgaacca tattgatgag 2984 ataaataggg ctgggggctg ggccccgctg gtcactcaac agagtatttc ccttggccga 3044 gatggaagtt ttgtcccaat agatgagctg ctgagtatca acaaggtgac atttttctgc 3104 tgcccatttg tgtcctggag acggtggtac cctgaaggca gaggccagct gccgcaagac 3164 agcaatgaca gtccacctgc cgacctgatt cctgcatcat ggaataacca catggctacc 3224 ttctatcctc tgttcccaaa tggtggtggc acttatcctg aagtcgtcaa tgatttccct 3284 tcgaaactac tttattttac taatttaaac tattttgtac tgatgtagcc ctgaggtagt 3344 tcatgaaaat gctgtgcact cattccatgg aataaatgtt ggaaagctga tcttttctga 3404 tataaaatgt tgaatgatat t 3425 <210> 8 <211> 570 <212> PRT <213> Homo sapiens <400> 8 Met Ala Phe Arg Gly Trp Arg Pro Pro Pro Pro Pro Leu Leu Leu Leu 1 5 10 15 Leu Leu Trp Val Thr Gly Gln Ala Ala Pro Val Ala Gly Leu Gly Ser 20 25 30 Asp Ala Glu Leu Gln Ile Glu Arg Arg Phe Val Pro Asp Glu Cys Pro 35 40 45 Arg Thr Val Arg Ser Gly Asp Phe Val Arg Tyr His Tyr Val Gly Thr 50 55 60 Phe Pro Asp Gly Gln Lys Phe Asp Ser Ser Tyr Asp Arg Asp Ser Thr 65 70 75 80 Phe Asn Val Phe Val Gly Lys Gly Gln Leu Ile Thr Gly Met Asp Gln 85 90 95 Ala Leu Val Gly Met Cys Val Asn Glu Arg Arg Phe Val Lys Ile Pro 100 105 110 Pro Lys Leu Ala Tyr Gly Asn Glu Gly Val Ser Gly Val Ile Pro Pro 115 120 125 Asn Ser Val Leu His Phe Asp Val Leu Leu Met Asp Ile Trp Asn Ser 130 135 140 Glu Asp Gln Val Gln Ile His Thr Tyr Phe Lys Pro Pro Ser Cys Pro 145 150 155 160 Arg Thr Ile Gln Val Ser Asp Phe Val Arg Tyr His Tyr Asn Gly Thr 165 170 175 Phe Leu Asp Gly Thr Leu Phe Asp Ser Ser His Asn Arg Met Lys Thr 180 185 190 Tyr Asp Thr Tyr Val Gly Ile Gly Trp Leu Ile Pro Gly Met Asp Lys 195 200 205 Gly Leu Leu Gly Met Cys Val Gly Glu Lys Arg Ile Ile Thr Ile Pro 210 215 220 Pro Phe Leu Ala Tyr Gly Glu Asp Gly Asp Gly Lys Asp Ile Pro Gly 225 230 235 240 Gln Ala Ser Leu Val Phe Asp Val Ala Leu Leu Asp Leu His Asn Pro 245 250 255 Lys Asp Ser Ile Ser Ile Glu Asn Lys Val Val Pro Glu Asn Cys Glu 260 265 270 Arg Ile Ser Gln Ser Gly Asp Phe Leu Arg Tyr His Tyr Asn Gly Thr 275 280 285 Leu Leu Asp Gly Thr Leu Phe Asp Ser Ser Tyr Ser Arg Asn Arg Thr 290 295 300 Phe Asp Thr Tyr Ile Gly Gln Gly Tyr Val Ile Pro Gly Met Asp Glu 305 310 315 320 Gly Leu Leu Gly Val Cys Ile Gly Glu Lys Arg Arg Ile Val Val Pro 325 330 335 Pro His Leu Gly Tyr Gly Glu Glu Gly Arg Gly Asn Ile Pro Gly Ser 340 345 350 Ala Val Leu Val Phe Asp Ile His Val Ile Asp Phe His Asn Pro Ser 355 360 365 Asp Ser Ile Ser Ile Thr Ser His Tyr Lys Pro Pro Asp Cys Ser Val 370 375 380 Leu Ser Lys Lys Gly Asp Tyr Leu Lys Tyr His Tyr Asn Ala Ser Leu 385 390 395 400 Leu Asp Gly Thr Leu Leu Asp Ser Thr Trp Asn Leu Gly Lys Thr Tyr 405 410 415 Asn Ile Val Leu Gly Ser Gly Gln Val Val Leu Gly Met Asp Met Gly 420 425 430 Leu Arg Glu Met Cys Val Gly Glu Lys Arg Thr Val Ile Ile Pro Pro 435 440 445 His Leu Gly Tyr Gly Glu Ala Gly Val Asp Gly Glu Val Pro Gly Ser 450 455 460 Ala Val Leu Val Phe Asp Ile Glu Leu Pro Glu Leu Val Ala Gly Leu 465 470 475 480 Pro Glu Gly Tyr Met Phe Ile Trp Asn Gly Glu Val Ser Pro Asn Leu 485 490 495 Phe Glu Glu Ile Asp Lys Asp Gly Asn Gly Glu Val Leu Leu Glu Glu 500 505 510 Phe Ser Glu Tyr Ile His Ala Gln Val Ala Ser Gly Lys Gly Lys Leu 515 520 525 Ala Pro Gly Phe Asp Ala Glu Leu Ile Val Lys Asn Met Phe Thr Asn 530 535 540 Gln Asp Arg Asn Gly Asp Gly Lys Val Thr Ala Glu Glu Phe Lys Leu 545 550 555 560 Lys Asp Gln Glu Ala Lys His Asp Glu Leu 565 570 <210> 9 <211> 978 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (30)..(674) <400> 9 tcttccgggt ggggccccgg gccgaggcg atg gcg ccc tgg gcg ctc ctc agc 53 Met Ala Pro Trp Ala Leu Leu Ser 1 5 cct ggg gtc ctg gtg cgg acc ggg cac acc gtg ctg acc tgg gga atc 101 Pro Gly Val Leu Val Arg Thr Gly His Thr Val Leu Thr Trp Gly Ile 10 15 20 acg ctg gtg ctc ttc ctg cac gat acc gag ctg cgg caa tgg gag gag 149 Thr Leu Val Leu Phe Leu His Asp Thr Glu Leu Arg Gln Trp Glu Glu 25 30 35 40 cag ggg gag ctg ctc ctg ccc ctc acc ttc ctg ctc ctg gtg ctg ggc 197 Gln Gly Glu Leu Leu Leu Pro Leu Thr Phe Leu Leu Leu Val Leu Gly 45 50 55 tcc ctg ctg ctc tac ctc gct gtg tca ctc atg gac cct ggc tac gtg 245 Ser Leu Leu Leu Tyr Leu Ala Val Ser Leu Met Asp Pro Gly Tyr Val 60 65 70 aat gtg cag ccc cag cct cag gag gag ctc aaa gag gag cag aca gcc 293 Asn Val Gln Pro Gln Pro Gln Glu Glu Leu Lys Glu Glu Gln Thr Ala 75 80 85 atg gtt cct cca gcc atc cct ctt cgg cgc tgc aga tac tgc ctg gtg 341 Met Val Pro Pro Ala Ile Pro Leu Arg Arg Cys Arg Tyr Cys Leu Val 90 95 100 ctg cag ccc ctg agg gct cgg cac tgc cgt gag tgc cgc cgt tgc gtc 389 Leu Gln Pro Leu Arg Ala Arg His Cys Arg Glu Cys Arg Arg Cys Val 105 110 115 120 cgc cgc tac gac cac cac tgc ccc tgg atg gag aac tgt gtg gga gag 437 Arg Arg Tyr Asp His His Cys Pro Trp Met Glu Asn Cys Val Gly Glu 125 130 135 cgc aac cac cca ctc ttt gtg gtc tac ctg gcg ctg cag ctg gtg gtg 485 Arg Asn His Pro Leu Phe Val Val Tyr Leu Ala Leu Gln Leu Val Val 140 145 150 ctt ctg tgg ggc ctg tac ctg gca tgg tca ggc ctc cgg ttc ttc cag 533 Leu Leu Trp Gly Leu Tyr Leu Ala Trp Ser Gly Leu Arg Phe Phe Gln 155 160 165 ccc tgg ggt ctg tgg ttg cgg tcc agc ggg ctc ctg ttc gcc acc ttc 581 Pro Trp Gly Leu Trp Leu Arg Ser Ser Gly Leu Leu Phe Ala Thr Phe 170 175 180 ctg ctg ctg tcc cac ttc ttc tgt gga tgg ccc tca ggg tcc tgg gag 629 Leu Leu Leu Ser His Phe Phe Cys Gly Trp Pro Ser Gly Ser Trp Glu 185 190 195 200 acc ctc tgg gct gag gag gag gaa gag ggc agc agc cca gct gtt 674 Thr Leu Trp Ala Glu Glu Glu Glu Glu Gly Ser Ser Pro Ala Val 205 210 215 tagggttgct ggaggccggg ctaccgtctt gtgcctgaaa accacggggc ctgtccccag 734 ctggggtgag cgctcagagg gcctggggcc ctcactcctg cccacgcctc ccagacccca 794 gaacggagct tcaagtcaga cagatccctg ccttggtggg cagttctgcc ttccaaggaa 854 gaaggggaag aaaaggacct gtgggtggct caggcccaag cagaccccgg gctccacccc 914 agccccgccc aggctgctgc cagtgcacac ttttacaaat ttaatataaa gcaagtccag 974 tctt 978 <210> 10 <211> 215 <212> PRT <213> Homo sapiens <400> 10 Met Ala Pro Trp Ala Leu Leu Ser Pro Gly Val Leu Val Arg Thr Gly 1 5 10 15 His Thr Val Leu Thr Trp Gly Ile Thr Leu Val Leu Phe Leu His Asp 20 25 30 Thr Glu Leu Arg Gln Trp Glu Glu Gln Gly Glu Leu Leu Leu Pro Leu 35 40 45 Thr Phe Leu Leu Leu Val Leu Gly Ser Leu Leu Leu Tyr Leu Ala Val 50 55 60 Ser Leu Met Asp Pro Gly Tyr Val Asn Val Gln Pro Gln Pro Gln Glu 65 70 75 80 Glu Leu Lys Glu Glu Gln Thr Ala Met Val Pro Pro Ala Ile Pro Leu 85 90 95 Arg Arg Cys Arg Tyr Cys Leu Val Leu Gln Pro Leu Arg Ala Arg His 100 105 110 Cys Arg Glu Cys Arg Arg Cys Val Arg Arg Tyr Asp His His Cys Pro 115 120 125 Trp Met Glu Asn Cys Val Gly Glu Arg Asn His Pro Leu Phe Val Val 130 135 140 Tyr Leu Ala Leu Gln Leu Val Val Leu Leu Trp Gly Leu Tyr Leu Ala 145 150 155 160 Trp Ser Gly Leu Arg Phe Phe Gln Pro Trp Gly Leu Trp Leu Arg Ser 165 170 175 Ser Gly Leu Leu Phe Ala Thr Phe Leu Leu Leu Ser His Phe Phe Cys 180 185 190 Gly Trp Pro Ser Gly Ser Trp Glu Thr Leu Trp Ala Glu Glu Glu Glu 195 200 205 Glu Gly Ser Ser Pro Ala Val 210 215 <210> 11 <211> 1499 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (58)..(606) <400> 11 gcggctgcag cgggcttgta ggtgtccggc tttgctggcc cagcaagcct gataagc 57 atg aag ctc tta tct ttg gtg gcc gtg gtc ggg tgt ttg ctg gtg ccc 105 Met Lys Leu Leu Ser Leu Val Ala Val Val Gly Cys Leu Leu Val Pro 1 5 10 15 cca gct gaa gcc aac aag agt tct gaa gat atc cgg tgc aaa tgc atc 153 Pro Ala Glu Ala Asn Lys Ser Ser Glu Asp Ile Arg Cys Lys Cys Ile 20 25 30 tgt cca cct tat aga aac atc agt ggg cat att tac aac cag aat gta 201 Cys Pro Pro Tyr Arg Asn Ile Ser Gly His Ile Tyr Asn Gln Asn Val 35 40 45 tcc cag aag gac tgc aac tgc ctg cac gtg gtg gag ccc atg cca gtg 249 Ser Gln Lys Asp Cys Asn Cys Leu His Val Val Glu Pro Met Pro Val 50 55 60 cct ggc cat gac gtg gag gcc tac tgc ctg ctg tgc gag tgc agg tac 297 Pro Gly His Asp Val Glu Ala Tyr Cys Leu Leu Cys Glu Cys Arg Tyr 65 70 75 80 gag gag cgc agc acc acc acc atc aag gtc atc att gtc atc tac ctg 345 Glu Glu Arg Ser Thr Thr Thr Ile Lys Val Ile Ile Val Ile Tyr Leu 85 90 95 tcc gtg gtg ggt gcc ctg ttg ctc tac atg gcc ttc ctg atg ctg gtg 393 Ser Val Val Gly Ala Leu Leu Leu Tyr Met Ala Phe Leu Met Leu Val 100 105 110 gac cct ctg atc cga aag ccg gat gca tac act gag caa ctg cac aat 441 Asp Pro Leu Ile Arg Lys Pro Asp Ala Tyr Thr Glu Gln Leu His Asn 115 120 125 gag gag gag aat gag gat gct cgc tct atg gca gca gct gct gca tcc 489 Glu Glu Glu Asn Glu Asp Ala Arg Ser Met Ala Ala Ala Ala Ala Ser 130 135 140 ctc ggg gga ccc cga gca aac aca gtc ctg gag cgt gtg gaa ggt gcc 537 Leu Gly Gly Pro Arg Ala Asn Thr Val Leu Glu Arg Val Glu Gly Ala 145 150 155 160 cag cag cgg tgg aag ctg cag gtg cag gag cag cgg aag aca gtc ttc 585 Gln Gln Arg Trp Lys Leu Gln Val Gln Glu Gln Arg Lys Thr Val Phe 165 170 175 gat cgg cac aag atg ctc agc tagatgggct ggtgtggttg ggtcaaggcc 636 Asp Arg His Lys Met Leu Ser 180 ccaacaccat ggctgccagc ttccaggctg gacaaagcag ggggctactt ctcccttccc 696 tcggttccag tcttcccttt aaaagcctgt ggcatttttc ctccttctcc ctaactttag 756 aaatgttgta cttggctatt ttgattaggg aagagggatg tggtctctga tctctgttgt 816 cttcttgggt ctttggggtt gaagggatgg ggaaggcagg ccagaaggga atggagacat 876 tcgaggcggc ctcaggagtg gatgcgatct gtctctcctg gctccactct tgccgccttc 936 cagctctgag tcttgggaat gttgttaccc ttggaagata aagctgggtc ttcaggaact 996 cagtgtctgg gaggaaagca tggcccagca ttcagcatgt gttcctttct gcagtggttc 1056 ttatcaccac ctccctccca gccccagcgc ctcagcccca gccccagctc cagccctgag 1116 gacagctctg atgggagagc tgggccccct gagcccactg ggtcttcagg gtgcactgga 1176 agctggtgtt cgctgtcccc tgtgcacttc tcgcactggg gcatggagtg cccatgcata 1236 ctctgctgcc ggtcccctca cctgcacttg aggggtctgg gcagtccctc ctctccccag 1296 tgtccacagt cactgagcca gacggtcggt tggaacatga gactcgaggc tgagcgtgga 1356 tctgaacacc acagcccctg tacttgggtt gcctcttgtc cctgaacttc gttgtaccag 1416 tgcatggaga gaaaattttg tcctcttgtc ttagagttgt gtgtaaatca aggaagccat 1476 cattaaattg ttttatttct ctc 1499 <210> 12 <211> 183 <212> PRT <213> Homo sapiens <400> 12 Met Lys Leu Leu Ser Leu Val Ala Val Val Gly Cys Leu Leu Val Pro 1 5 10 15 Pro Ala Glu Ala Asn Lys Ser Ser Glu Asp Ile Arg Cys Lys Cys Ile 20 25 30 Cys Pro Pro Tyr Arg Asn Ile Ser Gly His Ile Tyr Asn Gln Asn Val 35 40 45 Ser Gln Lys Asp Cys Asn Cys Leu His Val Val Glu Pro Met Pro Val 50 55 60 Pro Gly His Asp Val Glu Ala Tyr Cys Leu Leu Cys Glu Cys Arg Tyr 65 70 75 80 Glu Glu Arg Ser Thr Thr Thr Ile Lys Val Ile Ile Val Ile Tyr Leu 85 90 95 Ser Val Val Gly Ala Leu Leu Leu Tyr Met Ala Phe Leu Met Leu Val 100 105 110 Asp Pro Leu Ile Arg Lys Pro Asp Ala Tyr Thr Glu Gln Leu His Asn 115 120 125 Glu Glu Glu Asn Glu Asp Ala Arg Ser Met Ala Ala Ala Ala Ala Ser 130 135 140 Leu Gly Gly Pro Arg Ala Asn Thr Val Leu Glu Arg Val Glu Gly Ala 145 150 155 160 Gln Gln Arg Trp Lys Leu Gln Val Gln Glu Gln Arg Lys Thr Val Phe 165 170 175 Asp Arg His Lys Met Leu Ser 180 <210> 13 <211> 3125 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (77)..(895) <400> 13 gtaaataatc tcggaaaggc gagaaagaag ctgtctccat cttgtctgta tccgctgctc 60 ttgtgacgtt gtggag atg ggg agc gtc ctg ggg ctg tgc tcc atg gcg agc 112 Met Gly Ser Val Leu Gly Leu Cys Ser Met Ala Ser 1 5 10 tgg ata cca tgt ttg tgt gga agt gcc ccg tgt ttg cta tgc cga tgc 160 Trp Ile Pro Cys Leu Cys Gly Ser Ala Pro Cys Leu Leu Cys Arg Cys 15 20 25 tgt cct agt gga aac aac tcc act gta act aga ttg atc tat gca ctt 208 Cys Pro Ser Gly Asn Asn Ser Thr Val Thr Arg Leu Ile Tyr Ala Leu 30 35 40 ttc ttg ctt gtt gga gta tgt gta gct tgt gta atg ttg ata cca gga 256 Phe Leu Leu Val Gly Val Cys Val Ala Cys Val Met Leu Ile Pro Gly 45 50 55 60 atg gaa gaa caa ctg aat aag att cct gga ttt tgt gag aat gag aaa 304 Met Glu Glu Gln Leu Asn Lys Ile Pro Gly Phe Cys Glu Asn Glu Lys 65 70 75 ggt gtt gtc cct tgt aac att ttg gtt ggc tat aaa gct gta tat cgt 352 Gly Val Val Pro Cys Asn Ile Leu Val Gly Tyr Lys Ala Val Tyr Arg 80 85 90 ttg tgc ttt ggt ttg gct atg tcc tat ctt ctt ctc tct tta cta atg 400 Leu Cys Phe Gly Leu Ala Met Ser Tyr Leu Leu Leu Ser Leu Leu Met 95 100 105 atc aaa gtg aag agt agc agt gat cct aga gct gca gtg cac aat gga 448 Ile Lys Val Lys Ser Ser Ser Asp Pro Arg Ala Ala Val His Asn Gly 110 115 120 ttt tgg ttc ttt aaa ttt gct gca gca att gca att att att ggg gca 496 Phe Trp Phe Phe Lys Phe Ala Ala Ala Ile Ala Ile Ile Ile Gly Ala 125 130 135 140 ttc ttc att cca gaa gga act ttt aca act gtg tgg ttt tat gta ggc 544 Phe Phe Ile Pro Glu Gly Thr Phe Thr Thr Val Trp Phe Tyr Val Gly 145 150 155 atg gca ggt gcc ttt tgt ttc atc ctc ata caa cta gtc tta ctt att 592 Met Ala Gly Ala Phe Cys Phe Ile Leu Ile Gln Leu Val Leu Leu Ile 160 165 170 gat ttt gca cat tca tgg aat gaa tcg tgg gtt gaa aaa atg gaa gaa 640 Asp Phe Ala His Ser Trp Asn Glu Ser Trp Val Glu Lys Met Glu Glu 175 180 185 ggg aac tcg aga tgt tgg tat gca gcc ttg tta tca gct aca gct ctg 688 Gly Asn Ser Arg Cys Trp Tyr Ala Ala Leu Leu Ser Ala Thr Ala Leu 190 195 200 aat tat ctg ctg tct tta gtt gct atc gtc ctg ttc ttt gtc tac tac 736 Asn Tyr Leu Leu Ser Leu Val Ala Ile Val Leu Phe Phe Val Tyr Tyr 205 210 215 220 act cat cca gcc agt tgt tca gaa aac aag gcg ttc atc agt gtc aac 784 Thr His Pro Ala Ser Cys Ser Glu Asn Lys Ala Phe Ile Ser Val Asn 225 230 235 atg ctc ctc tgc gtt ggt gct tct gta atg tct ata ctg cca aaa atc 832 Met Leu Leu Cys Val Gly Ala Ser Val Met Ser Ile Leu Pro Lys Ile 240 245 250 caa gaa tca caa cca aga cct ggt ttg tta cag tct tca gta att cag 880 Gln Glu Ser Gln Pro Arg Pro Gly Leu Leu Gln Ser Ser Val Ile Gln 255 260 265 tct aca caa tgt att tgacatggtc agctatgacc aatgaaccag aaacaaattg 935 Ser Thr Gln Cys Ile 270 caacccaagt ctactaagca taattggcta caatacaaca agcactgtcc cacaggaagg 995 gcagtcagtc cagtggtggc atgctcaagg aattatagga ctaattctct ttttgttgtg 1055 tgtattttat tccagcatcc gtacttcaaa caatagtcag gttaataaac tgactctaac 1115 aagtgatgaa tctacattaa tagaagatgg tggagctaga agtgatggat cactggagga 1175 tggggacgat gttcaccgag ctgtagataa tgaaagggat ggtgtcactt acagttattc 1235 cttctttcac ttcatgcttt tcctggcttc actttatatc atgatgaccc ttaccaactg 1295 gtacaggtat gaaccctctc gtgagatgaa aagtcagtgg acagctgtct gggtgaaaat 1355 ctcttccagt tggattggca tcgtgctgta tgtttggaca ctcgtggcac cacttgttct 1415 tacaaatcgt gatttttact gagtgagact tctagcatga aagtcccact ttgattattg 1475 cttatttgaa aacagtattc ccaacttttg taaagttgtg tatgtttttg cttcccatgt 1535 aacttctcca gtgttctggc atgaattaga ttttactgct tgtcatttta ttattttctt 1595 accaagtgca ttgatatgtg aagtagaatg aattgcagag gaaagtttta tgaatatggt 1655 gatgagttag taaaagtggc cattattggg cttattctct gctctatagt tgtgaaatga 1715 agagtaaaaa caaatttgtt tgactatttt aaaattatat tagaccttaa gctgttttag 1775 caagcattaa agcaaatgta tggctgcctt ttgaaatatt tgacgtgttg cctggcagga 1835 tactgcaaag aacatggttt attttaaaat ttataaacaa gtcacttaaa tgccagttgt 1895 ctgaaaaatc ttataaggtt ttacccttga tacggaattt acacaggtag ggagtgttta 1955 gtggacaata gtgtaggtta tggatggagg tgtcggtact aaattgaata acgagtaaat 2015 aatcttactt gggtagagat ggcctttgcc aacaaagtga actgttttgg ttgttttaaa 2075 ctcatgaagt atgggttcag tggaaatgtt tggaactctg aaggatttag acaaggtttt 2135 gaaaaggata atcatgggtt agaaggaagt gtttgaaagt cactttgaaa gttagttttg 2195 ggccagcacg gtagctcacc cttgtaatcc cagcactttg ggaggctgag gtgggtagat 2255 tacttgagcc caggaattca agaccagcct gggcaacatg gtgaaaccct gtttctataa 2315 aaaataatct gggctttgta gcatatgcct gtggtcccag ctactgagga ggctgaggtg 2375 ggaggattgc ttgagcccag gaggcagagg ttgcagtgag ccaaggtcac gtcactgcac 2435 tctagcctgg gcaacagagt aagacaaaaa aatatatata tattgaaaat caaaggaggc 2495 aaaattttga cagggaagga agtaactgca aaacactagg ctttagtagg tacttatata 2555 aaatctagtc cagttctctc atttaaaaaa atgaagacac tgaaatacag acttagatag 2615 ctcagatagc taattaggaa atttcaagtt ggccaataat agcattctct ctgacattta 2675 aaaataattt ctattcaaaa tacatgcata attgatttta cacctcatta ctggtggata 2735 atttatgtga tgtggattgc tggtgtccag catgacccat aaacaggtca gaagaatgat 2795 ggaatgtttt agaataaact cctgcttata gtatactaca cagttcaaaa gatgtttaaa 2855 atgcttttgt atttactgcc atgtaattga aatatataga ttattgtaac ctttcaacct 2915 gaaaatcaag cagtatgaga gtttagttat ttgtatgtgt cactagtgtc taatgaagct 2975 tttaaaatct acaatttctt ctttaaaaat atttattaat gtgaatggaa tataacaatt 3035 cagcttaatt ccccaacctt attctgtgtg tagacattgt attccacaat tttgaatggc 3095 tgtgttttac ctctaaataa atgaattcag 3125 <210> 14 <211> 273 <212> PRT <213> Homo sapiens <400> 14 Met Gly Ser Val Leu Gly Leu Cys Ser Met Ala Ser Trp Ile Pro Cys 1 5 10 15 Leu Cys Gly Ser Ala Pro Cys Leu Leu Cys Arg Cys Cys Pro Ser Gly 20 25 30 Asn Asn Ser Thr Val Thr Arg Leu Ile Tyr Ala Leu Phe Leu Leu Val 35 40 45 Gly Val Cys Val Ala Cys Val Met Leu Ile Pro Gly Met Glu Glu Gln 50 55 60 Leu Asn Lys Ile Pro Gly Phe Cys Glu Asn Glu Lys Gly Val Val Pro 65 70 75 80 Cys Asn Ile Leu Val Gly Tyr Lys Ala Val Tyr Arg Leu Cys Phe Gly 85 90 95 Leu Ala Met Ser Tyr Leu Leu Leu Ser Leu Leu Met Ile Lys Val Lys 100 105 110 Ser Ser Ser Asp Pro Arg Ala Ala Val His Asn Gly Phe Trp Phe Phe 115 120 125 Lys Phe Ala Ala Ala Ile Ala Ile Ile Ile Gly Ala Phe Phe Ile Pro 130 135 140 Glu Gly Thr Phe Thr Thr Val Trp Phe Tyr Val Gly Met Ala Gly Ala 145 150 155 160 Phe Cys Phe Ile Leu Ile Gln Leu Val Leu Leu Ile Asp Phe Ala His 165 170 175 Ser Trp Asn Glu Ser Trp Val Glu Lys Met Glu Glu Gly Asn Ser Arg 180 185 190 Cys Trp Tyr Ala Ala Leu Leu Ser Ala Thr Ala Leu Asn Tyr Leu Leu 195 200 205 Ser Leu Val Ala Ile Val Leu Phe Phe Val Tyr Tyr Thr His Pro Ala 210 215 220 Ser Cys Ser Glu Asn Lys Ala Phe Ile Ser Val Asn Met Leu Leu Cys 225 230 235 240 Val Gly Ala Ser Val Met Ser Ile Leu Pro Lys Ile Gln Glu Ser Gln 245 250 255 Pro Arg Pro Gly Leu Leu Gln Ser Ser Val Ile Gln Ser Thr Gln Cys 260 265 270 Ile <210> 15 <211> 1927 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (118)..(1134) <400> 15 ggcgttcctt cgccgccgcc aggggtagcg gtgtagctgc gcagcgtcgc gcgcgctacc 60 gcacccaggt tcggcccgta ggcgtctggc agcccggcgc catcttcatc gagcgcc 117 atg gcc gca gcc tgc ggg ccg gga gcg gcc ggg tac tgc ttg ctc ctc 165 Met Ala Ala Ala Cys Gly Pro Gly Ala Ala Gly Tyr Cys Leu Leu Leu 1 5 10 15 ggc ttg cat ttg ttt ctg ctg acc gcg ggc cct gcc ctg ggc tgg aac 213 Gly Leu His Leu Phe Leu Leu Thr Ala Gly Pro Ala Leu Gly Trp Asn 20 25 30 gac cct gac aga atg ttg ctg cgg gat gta aaa gct ctt acc ctc cac 261 Asp Pro Asp Arg Met Leu Leu Arg Asp Val Lys Ala Leu Thr Leu His 35 40 45 tat gac cgc tat acc acc tcc cgc agg ctg gat ccc atc cca cag ttg 309 Tyr Asp Arg Tyr Thr Thr Ser Arg Arg Leu Asp Pro Ile Pro Gln Leu 50 55 60 aaa tgt gtt gga ggc aca gct ggt tgt gat tct tat acc cca aaa gtc 357 Lys Cys Val Gly Gly Thr Ala Gly Cys Asp Ser Tyr Thr Pro Lys Val 65 70 75 80 ata cag tgt cag aac aaa ggc tgg gat ggg tat gat gta cag tgg gaa 405 Ile Gln Cys Gln Asn Lys Gly Trp Asp Gly Tyr Asp Val Gln Trp Glu 85 90 95 tgt aag acg gac tta gat att gca tac aaa ttt gga aaa act gtg gtg 453 Cys Lys Thr Asp Leu Asp Ile Ala Tyr Lys Phe Gly Lys Thr Val Val 100 105 110 agc tgt gaa ggc tat gag tcc tct gaa gac cag tat gta cta aga ggt 501 Ser Cys Glu Gly Tyr Glu Ser Ser Glu Asp Gln Tyr Val Leu Arg Gly 115 120 125 tct tgt ggc ttg gag tat aat tta gat tat aca gaa ctt ggc ctg cag 549 Ser Cys Gly Leu Glu Tyr Asn Leu Asp Tyr Thr Glu Leu Gly Leu Gln 130 135 140 gaa ctg aag gag tct gga aag cag cac ggc ttt gcc tct ttc tct gat 597 Glu Leu Lys Glu Ser Gly Lys Gln His Gly Phe Ala Ser Phe Ser Asp 145 150 155 160 tat tat tat aag tgg tcc tcg gcg gat tcc tgt aac atg agt gga ttg 645 Tyr Tyr Tyr Lys Trp Ser Ser Ala Asp Ser Cys Asn Met Ser Gly Leu 165 170 175 att acc atc gtg gta ctc ctt ggg atc gcc ttt gta gtc tat aag ctg 693 Ile Thr Ile Val Val Leu Leu Gly Ile Ala Phe Val Val Tyr Lys Leu 180 185 190 ttc ctg agt gac ggg cag tat tct cct cca ccg tac tct gag tat cct 741 Phe Leu Ser Asp Gly Gln Tyr Ser Pro Pro Pro Tyr Ser Glu Tyr Pro 195 200 205 cca ttt tcc cac cgt tac cag aga ttc acc aac tca gca gga cct cct 789 Pro Phe Ser His Arg Tyr Gln Arg Phe Thr Asn Ser Ala Gly Pro Pro 210 215 220 ccc cca ggc ttt aag tct gag ttc aca gga cca cag aat act ggc cat 837 Pro Pro Gly Phe Lys Ser Glu Phe Thr Gly Pro Gln Asn Thr Gly His 225 230 235 240 ggt gca act tct ggt ttt ggc agt gct ttt aca gga caa caa gga tat 885 Gly Ala Thr Ser Gly Phe Gly Ser Ala Phe Thr Gly Gln Gln Gly Tyr 245 250 255 gaa aat tca gga cca ggg ttc tgg aca ggc ttg gga act ggt gga ata 933 Glu Asn Ser Gly Pro Gly Phe Trp Thr Gly Leu Gly Thr Gly Gly Ile 260 265 270 cta gga tat ttg ttt ggc agc aat aga gcg gca aca ccc ttc tca gac 981 Leu Gly Tyr Leu Phe Gly Ser Asn Arg Ala Ala Thr Pro Phe Ser Asp 275 280 285 tcg tgg tac tac ccg tcc tat cct ccc tcc tac cct ggc acg tgg aat 1029 Ser Trp Tyr Tyr Pro Ser Tyr Pro Pro Ser Tyr Pro Gly Thr Trp Asn 290 295 300 agg gct tac tca ccc ctt cat gga ggc tcg ggc agc tat tcg gta tgt 1077 Arg Ala Tyr Ser Pro Leu His Gly Gly Ser Gly Ser Tyr Ser Val Cys 305 310 315 320 tca aac tca gac acg aaa acc aga act gca tca gga tat ggt ggt acc 1125 Ser Asn Ser Asp Thr Lys Thr Arg Thr Ala Ser Gly Tyr Gly Gly Thr 325 330 335 agg aga cga taaagtagaa agttggagtc aaacactgga tgcagaaatt 1174 Arg Arg Arg ttggattttt catcactttc tctttagaaa aaaagtacta cctgttaaca attgggaaaa 1234 ggggatattc aaaagttctg tggtgttatg tccagtgtag ctttttgtat tctattattt 1294 gaggctaaaa gttgatgtgt gacaaaatac ttatgtgttg tatgtcagtg taacatgcag 1354 atgtatattg cagtttttga aagtgatcat tacagtggaa cgctaaaaat acattaattt 1414 ctaaaacctg tgatgcccta agaagcatta agaatgaagg tgttgtacta atagaaacta 1474 agtacagaaa atttcagttt taggtggttg tagctgatga gttattacct catagagact 1534 ataatattct atttggtatt atattatttg atgtttgctg ttcttcaaac atttaaatca 1594 agctttggac taattatgct aatttgtgag ttctgatcac ttttgagctc tgaagctttg 1654 aatcattcag tggtggagat ggccttctgg taactgaata ttaccttctg taggaaaagg 1714 tagaaaataa gcatctagaa ggttgttgtg aatgactctg tgctggcaaa aatgcttgaa 1774 acctctatat ttctttcgtt cataagaggt aaaggtcaaa tttttcaaca aaagtctttt 1834 aataacaaaa gcatgcagtt ctctgtgaaa tctcaaatat tgttgtaata gtctgtttca 1894 atcttaaaaa gaatcaataa aaacaaacaa ggg 1927 <210> 16 <211> 339 <212> PRT <213> Homo sapiens <400> 16 Met Ala Ala Ala Cys Gly Pro Gly Ala Ala Gly Tyr Cys Leu Leu Leu 1 5 10 15 Gly Leu His Leu Phe Leu Leu Thr Ala Gly Pro Ala Leu Gly Trp Asn 20 25 30 Asp Pro Asp Arg Met Leu Leu Arg Asp Val Lys Ala Leu Thr Leu His 35 40 45 Tyr Asp Arg Tyr Thr Thr Ser Arg Arg Leu Asp Pro Ile Pro Gln Leu 50 55 60 Lys Cys Val Gly Gly Thr Ala Gly Cys Asp Ser Tyr Thr Pro Lys Val 65 70 75 80 Ile Gln Cys Gln Asn Lys Gly Trp Asp Gly Tyr Asp Val Gln Trp Glu 85 90 95 Cys Lys Thr Asp Leu Asp Ile Ala Tyr Lys Phe Gly Lys Thr Val Val 100 105 110 Ser Cys Glu Gly Tyr Glu Ser Ser Glu Asp Gln Tyr Val Leu Arg Gly 115 120 125 Ser Cys Gly Leu Glu Tyr Asn Leu Asp Tyr Thr Glu Leu Gly Leu Gln 130 135 140 Glu Leu Lys Glu Ser Gly Lys Gln His Gly Phe Ala Ser Phe Ser Asp 145 150 155 160 Tyr Tyr Tyr Lys Trp Ser Ser Ala Asp Ser Cys Asn Met Ser Gly Leu 165 170 175 Ile Thr Ile Val Val Leu Leu Gly Ile Ala Phe Val Val Tyr Lys Leu 180 185 190 Phe Leu Ser Asp Gly Gln Tyr Ser Pro Pro Pro Tyr Ser Glu Tyr Pro 195 200 205 Pro Phe Ser His Arg Tyr Gln Arg Phe Thr Asn Ser Ala Gly Pro Pro 210 215 220 Pro Pro Gly Phe Lys Ser Glu Phe Thr Gly Pro Gln Asn Thr Gly His 225 230 235 240 Gly Ala Thr Ser Gly Phe Gly Ser Ala Phe Thr Gly Gln Gln Gly Tyr 245 250 255 Glu Asn Ser Gly Pro Gly Phe Trp Thr Gly Leu Gly Thr Gly Gly Ile 260 265 270 Leu Gly Tyr Leu Phe Gly Ser Asn Arg Ala Ala Thr Pro Phe Ser Asp 275 280 285 Ser Trp Tyr Tyr Pro Ser Tyr Pro Pro Ser Tyr Pro Gly Thr Trp Asn 290 295 300 Arg Ala Tyr Ser Pro Leu His Gly Gly Ser Gly Ser Tyr Ser Val Cys 305 310 315 320 Ser Asn Ser Asp Thr Lys Thr Arg Thr Ala Ser Gly Tyr Gly Gly Thr 325 330 335 Arg Arg Arg <210> 17 <211> 1483 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (70)..(1248) <400> 17 aaaaaaaaaa aaaaaaaaaa ctcgctggcg gagcggctgg gcggcgggcc gggcccgggg 60 ccgcttgga atg gcg cct cct ccg cct tcg ccc caa ctg ctt ctc ctg gca 111 Met Ala Pro Pro Pro Pro Ser Pro Gln Leu Leu Leu Leu Ala 1 5 10 gcc ctc gcg agg ctc ctg ggt ccc agc gag gtg atg gct gga ccg gcg 159 Ala Leu Ala Arg Leu Leu Gly Pro Ser Glu Val Met Ala Gly Pro Ala 15 20 25 30 gag gag gcg gga gcc cat tgt ccc gag agc ctg tgg cct ctg cct ccg 207 Glu Glu Ala Gly Ala His Cys Pro Glu Ser Leu Trp Pro Leu Pro Pro 35 40 45 cag gtg tca cca aga gtg acc tac aca cga gtg agc cca ggg cag gct 255 Gln Val Ser Pro Arg Val Thr Tyr Thr Arg Val Ser Pro Gly Gln Ala 50 55 60 gag gat gtc acc ttc ctc tac cac ccc tgt gcc cat ccc tgg ctg aag 303 Glu Asp Val Thr Phe Leu Tyr His Pro Cys Ala His Pro Trp Leu Lys 65 70 75 ctc cag ctt gcc ctc ctg gcc tat gct tgt atg gct aac cct tcc ctc 351 Leu Gln Leu Ala Leu Leu Ala Tyr Ala Cys Met Ala Asn Pro Ser Leu 80 85 90 acc cct gac ttc agc ctc acg cag gat cgg ccc ctg gtg ctg act gca 399 Thr Pro Asp Phe Ser Leu Thr Gln Asp Arg Pro Leu Val Leu Thr Ala 95 100 105 110 tgg ggg ctg gcg ctg gag atg gcc tgg gta gag cca gcc tgg gct gcc 447 Trp Gly Leu Ala Leu Glu Met Ala Trp Val Glu Pro Ala Trp Ala Ala 115 120 125 cac tgg ctg atg agg agg cgg agg agg aag cag agg aag aag aag gca 495 His Trp Leu Met Arg Arg Arg Arg Arg Lys Gln Arg Lys Lys Lys Ala 130 135 140 tgg atc tac tgt gaa agc ctt tca ggg cct gct ccc tcc gag cca act 543 Trp Ile Tyr Cys Glu Ser Leu Ser Gly Pro Ala Pro Ser Glu Pro Thr 145 150 155 ccc ggt aga ggg agg ctg tgc cga aga ggg tgt gtg cag gcc ctg gct 591 Pro Gly Arg Gly Arg Leu Cys Arg Arg Gly Cys Val Gln Ala Leu Ala 160 165 170 ctg gcc ttt gct ctg cgg agc tgg cgg ccc cct ggc aca gag gtg aca 639 Leu Ala Phe Ala Leu Arg Ser Trp Arg Pro Pro Gly Thr Glu Val Thr 175 180 185 190 tct caa ggg ccc agg cag ccc tct tct agt ggt gcc aag agg cgg agg 687 Ser Gln Gly Pro Arg Gln Pro Ser Ser Ser Gly Ala Lys Arg Arg Arg 195 200 205 ctg cgg gct gcc ctt ggt ccc cag ccc act cgc tca gcc ctg agg ttt 735 Leu Arg Ala Ala Leu Gly Pro Gln Pro Thr Arg Ser Ala Leu Arg Phe 210 215 220 ccc tct gct tcc cca ggg agc ttg aag gcc aag cag tcc atg gcg gga 783 Pro Ser Ala Ser Pro Gly Ser Leu Lys Ala Lys Gln Ser Met Ala Gly 225 230 235 atc cct ggt agg gag agt aat gcc cca tct gtg ccc act gtc tcc ctg 831 Ile Pro Gly Arg Glu Ser Asn Ala Pro Ser Val Pro Thr Val Ser Leu 240 245 250 ctg ccg ggg gcg cct gga ggc aat gcc agc tcc agg aca gag gct cag 879 Leu Pro Gly Ala Pro Gly Gly Asn Ala Ser Ser Arg Thr Glu Ala Gln 255 260 265 270 gtg ccc aac ggg caa ggc agc cca ggg ggc tgt gtc tgt tca agt cag 927 Val Pro Asn Gly Gln Gly Ser Pro Gly Gly Cys Val Cys Ser Ser Gln 275 280 285 gct tcc ccg gcc cct cgc gca gca gcg cct cca cgg gca gcc cgg ggc 975 Ala Ser Pro Ala Pro Arg Ala Ala Ala Pro Pro Arg Ala Ala Arg Gly 290 295 300 ccc acc cca cgc act gaa gag gcc gcc tgg gct gcc atg gcc ctg acc 1023 Pro Thr Pro Arg Thr Glu Glu Ala Ala Trp Ala Ala Met Ala Leu Thr 305 310 315 ttc ctg ctg gtg ctg ctc acc ctg gcc acg ctc tgc aca cgg ctg cac 1071 Phe Leu Leu Val Leu Leu Thr Leu Ala Thr Leu Cys Thr Arg Leu His 320 325 330 aga aac ttc cga cgc ggg gag agc atc tac tgg ggg ccc aca gcg gac 1119 Arg Asn Phe Arg Arg Gly Glu Ser Ile Tyr Trp Gly Pro Thr Ala Asp 335 340 345 350 agc cag gac aca gtg gct gct gtg ctg aag cgg agg ctg ctg cag ccc 1167 Ser Gln Asp Thr Val Ala Ala Val Leu Lys Arg Arg Leu Leu Gln Pro 355 360 365 tcg cgc cgg gtc aag cgc tcg cgc cgg aga ccc ctc ctc ccg ccc acg 1215 Ser Arg Arg Val Lys Arg Ser Arg Arg Arg Pro Leu Leu Pro Pro Thr 370 375 380 ccg gac agc ggc ccg gaa ggc gag agc tcg gag tgacggcctg ggacctgcca 1268 Pro Asp Ser Gly Pro Glu Gly Glu Ser Ser Glu 385 390 ctgtggcgtg cggctcctcc ccgcgccgcg aggccgcgac ctctgccacg tggaccgcgc 1328 gcggggcgct ccctggtggc gatggcgcgg cactggccga gcactgcggg ggctttcctc 1388 cttgttggtt gctgagtggg cggccaaggg gagaaaagga gccgcttctg cctcccttgc 1448 caaaactccg tttctaatta aattattttt agtag 1483 <210> 18 <211> 393 <212> PRT <213> Homo sapiens <400> 18 Met Ala Pro Pro Pro Pro Ser Pro Gln Leu Leu Leu Leu Ala Ala Leu 1 5 10 15 Ala Arg Leu Leu Gly Pro Ser Glu Val Met Ala Gly Pro Ala Glu Glu 20 25 30 Ala Gly Ala His Cys Pro Glu Ser Leu Trp Pro Leu Pro Pro Gln Val 35 40 45 Ser Pro Arg Val Thr Tyr Thr Arg Val Ser Pro Gly Gln Ala Glu Asp 50 55 60 Val Thr Phe Leu Tyr His Pro Cys Ala His Pro Trp Leu Lys Leu Gln 65 70 75 80 Leu Ala Leu Leu Ala Tyr Ala Cys Met Ala Asn Pro Ser Leu Thr Pro 85 90 95 Asp Phe Ser Leu Thr Gln Asp Arg Pro Leu Val Leu Thr Ala Trp Gly 100 105 110 Leu Ala Leu Glu Met Ala Trp Val Glu Pro Ala Trp Ala Ala His Trp 115 120 125 Leu Met Arg Arg Arg Arg Arg Lys Gln Arg Lys Lys Lys Ala Trp Ile 130 135 140 Tyr Cys Glu Ser Leu Ser Gly Pro Ala Pro Ser Glu Pro Thr Pro Gly 145 150 155 160 Arg Gly Arg Leu Cys Arg Arg Gly Cys Val Gln Ala Leu Ala Leu Ala 165 170 175 Phe Ala Leu Arg Ser Trp Arg Pro Pro Gly Thr Glu Val Thr Ser Gln 180 185 190 Gly Pro Arg Gln Pro Ser Ser Ser Gly Ala Lys Arg Arg Arg Leu Arg 195 200 205 Ala Ala Leu Gly Pro Gln Pro Thr Arg Ser Ala Leu Arg Phe Pro Ser 210 215 220 Ala Ser Pro Gly Ser Leu Lys Ala Lys Gln Ser Met Ala Gly Ile Pro 225 230 235 240 Gly Arg Glu Ser Asn Ala Pro Ser Val Pro Thr Val Ser Leu Leu Pro 245 250 255 Gly Ala Pro Gly Gly Asn Ala Ser Ser Arg Thr Glu Ala Gln Val Pro 260 265 270 Asn Gly Gln Gly Ser Pro Gly Gly Cys Val Cys Ser Ser Gln Ala Ser 275 280 285 Pro Ala Pro Arg Ala Ala Ala Pro Pro Arg Ala Ala Arg Gly Pro Thr 290 295 300 Pro Arg Thr Glu Glu Ala Ala Trp Ala Ala Met Ala Leu Thr Phe Leu 305 310 315 320 Leu Val Leu Leu Thr Leu Ala Thr Leu Cys Thr Arg Leu His Arg Asn 325 330 335 Phe Arg Arg Gly Glu Ser Ile Tyr Trp Gly Pro Thr Ala Asp Ser Gln 340 345 350 Asp Thr Val Ala Ala Val Leu Lys Arg Arg Leu Leu Gln Pro Ser Arg 355 360 365 Arg Val Lys Arg Ser Arg Arg Arg Pro Leu Leu Pro Pro Thr Pro Asp 370 375 380 Ser Gly Pro Glu Gly Glu Ser Ser Glu 385 390 <210> 19 <211> 1851 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (171)..(518) <400> 19 aaataatctt gcttgaagac tgacaagatg tccctgtgga ctcccaaact ctactccaga 60 tggggaggtg cccttaacac caagatttta aaagctccaa tttcagagca agagtcgaaa 120 actcacagat aaagttatag ttatttcagg gttctgaaaa gacgcagaac atg aag 176 Met Lys 1 gga ctc aga agt ctg gca gca aca acc ttg gct ctt ttc ctg gtg ttt 224 Gly Leu Arg Ser Leu Ala Ala Thr Thr Leu Ala Leu Phe Leu Val Phe 5 10 15 gtt ttc ctg gga aac tcc agc tgc gct ccg cag aga ctg ttg gag aga 272 Val Phe Leu Gly Asn Ser Ser Cys Ala Pro Gln Arg Leu Leu Glu Arg 20 25 30 agg aac tgg act cct caa gct atg ctc tac ctg aaa ggg gca cag ggt 320 Arg Asn Trp Thr Pro Gln Ala Met Leu Tyr Leu Lys Gly Ala Gln Gly 35 40 45 50 cgc cgc ttc atc tcc gac cag agc cgg aga aag gac ctc tcc gac cgg 368 Arg Arg Phe Ile Ser Asp Gln Ser Arg Arg Lys Asp Leu Ser Asp Arg 55 60 65 cca ctg ccg gaa aga cga agc cca aat ccc caa cta cta act att ccg 416 Pro Leu Pro Glu Arg Arg Ser Pro Asn Pro Gln Leu Leu Thr Ile Pro 70 75 80 gag gca gca acc atc tta ctg gcg tcc ctt cag aaa tca cca gaa gat 464 Glu Ala Ala Thr Ile Leu Leu Ala Ser Leu Gln Lys Ser Pro Glu Asp 85 90 95 gaa gaa aaa aac ttt gat caa acc aga ttc ctg gaa gac agt ctg ctt 512 Glu Glu Lys Asn Phe Asp Gln Thr Arg Phe Leu Glu Asp Ser Leu Leu 100 105 110 aac tgg tgaaaatata ctggattatg tttaattatg gttctattct ctttgaaaac 568 Asn Trp 115 atgaaccatg tgaataaaac ctttggaccc ttttattcca tttgtaatct taagaacaca 628 cacagatagt tttattcttt cagaaacaaa atatatatag gatgcttagc tgagaacatc 688 atcttctttc attgcttcag gtcctgttta gatgaccaaa aatgttttca gatcaccttg 748 tgtcttactc ttgagtttct tagaatattt ataattataa ggctgaagac taaagtgttc 808 tttcctttta actatagcca gtacctgtct tgatcttagt tgtgtttttt tttttcattt 868 tgttacccac ttgcattttg ttttcactca gcagaaattc tccttctctg ttttcctttt 928 atcccatccc caagaatgtg gaaggaaggt gagaaacatg gcaggatggg aaataggaga 988 gtatgactct ctatagctca tccaggagta atcaattaag aagataaatt ggatgactgt 1048 ggagaagctc tgtgatagga acacttcagt gtggttgctg agaggagaca gtcattgagg 1108 tagaaggttt gccaaagatc cagagctcag agctcccttt gtgctctttg ggaattacct 1168 tgcattcagt ttagaaacat ggatctaaaa gttactggga aataagcaga tggagacaca 1228 ctctgttgtt tacgtattgg aagaagggaa caagccagtt ttgttagagg taactcattt 1288 tccatgacca aacagactca acagattcaa gtactctgct tactctaatt gactagactc 1348 taggttttat ttgacatcat agcattacat aaatcactct gataacataa gtgcacagta 1408 atatgcctga tctcttcctt tttaaaagcc aacttgagtt cagtaccatc tgaatacaca 1468 cacatgcaca tatacccaca cacgcataca cacatactcc tgtggcaaac ataataatgt 1528 atttatttag aattataata tgaccatcat gttaattatt ttttacctaa tcagagttgt 1588 tattgacaaa tgtcataagt ggaaagtatt aattcttatt gtcatcagta tttagccatt 1648 atttagtagc tcaagaatat ctttatgtga atgtctctgt aacttggaat tgcaatttca 1708 ctgtgttaag taatcagaac tctgcttata agatttatct gtatcttgtt tcataattta 1768 ataatgaaac taaattcaag ttaatgtaat gttgatctcc gtcgaaaaat aacttgtgag 1828 cattaaaata tctgtatggc att 1851 <210> 20 <211> 116 <212> PRT <213> Homo sapiens <400> 20 Met Lys Gly Leu Arg Ser Leu Ala Ala Thr Thr Leu Ala Leu Phe Leu 1 5 10 15 Val Phe Val Phe Leu Gly Asn Ser Ser Cys Ala Pro Gln Arg Leu Leu 20 25 30 Glu Arg Arg Asn Trp Thr Pro Gln Ala Met Leu Tyr Leu Lys Gly Ala 35 40 45 Gln Gly Arg Arg Phe Ile Ser Asp Gln Ser Arg Arg Lys Asp Leu Ser 50 55 60 Asp Arg Pro Leu Pro Glu Arg Arg Ser Pro Asn Pro Gln Leu Leu Thr 65 70 75 80 Ile Pro Glu Ala Ala Thr Ile Leu Leu Ala Ser Leu Gln Lys Ser Pro 85 90 95 Glu Asp Glu Glu Lys Asn Phe Asp Gln Thr Arg Phe Leu Glu Asp Ser 100 105 110 Leu Leu Asn Trp 115 <210> 21 <211> 2395 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (25)..(1068) <400> 21 gatgaagggt cgttggtggg aaag atg gcg gcg gct ctg gga ccc ctt ggg 51 Met Ala Ala Ala Leu Gly Pro Leu Gly 1 5 tcg tgg cag cag tgg cgg cga tgt ttg tcg gct cgg gat ggg tcc agg 99 Ser Trp Gln Gln Trp Arg Arg Cys Leu Ser Ala Arg Asp Gly Ser Arg 10 15 20 25 atg tta ctc ctt ctt ctt ttg ttg ggg tct ggg cag ggg cca cag caa 147 Met Leu Leu Leu Leu Leu Leu Leu Gly Ser Gly Gln Gly Pro Gln Gln 30 35 40 gtc ggg gcg ggt caa acg ttc gag tac ttg aaa cgg gag cac tcg ctg 195 Val Gly Ala Gly Gln Thr Phe Glu Tyr Leu Lys Arg Glu His Ser Leu 45 50 55 tcg aag ccc tac cag ggt gtg ggc aca ggc agt tcc tca ctg tgg aat 243 Ser Lys Pro Tyr Gln Gly Val Gly Thr Gly Ser Ser Ser Leu Trp Asn 60 65 70 ctg atg ggc aat gcc atg gtg atg acc cag tat atc cgc ctt acc cca 291 Leu Met Gly Asn Ala Met Val Met Thr Gln Tyr Ile Arg Leu Thr Pro 75 80 85 gat atg caa agt aaa cag ggt gcc ttg tgg aac cgg gtg cca tgt ttc 339 Asp Met Gln Ser Lys Gln Gly Ala Leu Trp Asn Arg Val Pro Cys Phe 90 95 100 105 ctg aga gac tgg gag ttg cag gtg cac ttc aaa atc cat gga caa gga 387 Leu Arg Asp Trp Glu Leu Gln Val His Phe Lys Ile His Gly Gln Gly 110 115 120 aag aag aat ctg cat ggg gat ggc ttg gca atc tgg tac aca aag gat 435 Lys Lys Asn Leu His Gly Asp Gly Leu Ala Ile Trp Tyr Thr Lys Asp 125 130 135 cgg atg cag cca ggg cct gtg ttt gga aac atg gac aaa ttt gtg ggg 483 Arg Met Gln Pro Gly Pro Val Phe Gly Asn Met Asp Lys Phe Val Gly 140 145 150 ctg gga gta ttt gta gac acc tac ccc aat gag gag aag cag caa gag 531 Leu Gly Val Phe Val Asp Thr Tyr Pro Asn Glu Glu Lys Gln Gln Glu 155 160 165 cgg gta ttc ccc tac atc tca gcc atg gtg aac aac ggc tcc ctc agc 579 Arg Val Phe Pro Tyr Ile Ser Ala Met Val Asn Asn Gly Ser Leu Ser 170 175 180 185 tat gat cat gag cgg gat ggg cgg cct aca gag ctg gga ggc tgc aca 627 Tyr Asp His Glu Arg Asp Gly Arg Pro Thr Glu Leu Gly Gly Cys Thr 190 195 200 gcc att gtc cgc aat ctt cat tac gac acc ttc ctg gtg att cgc tac 675 Ala Ile Val Arg Asn Leu His Tyr Asp Thr Phe Leu Val Ile Arg Tyr 205 210 215 gtc aag agg cat ttg acg ata atg atg gat att gat ggc aag cat gag 723 Val Lys Arg His Leu Thr Ile Met Met Asp Ile Asp Gly Lys His Glu 220 225 230 tgg agg gac tgc att gaa gtg ccc gga gtc cgc ctg ccc cgc ggc tac 771 Trp Arg Asp Cys Ile Glu Val Pro Gly Val Arg Leu Pro Arg Gly Tyr 235 240 245 tac ttc ggc acc tcc tcc atc act ggg gat ctc tca gat aat cat gat 819 Tyr Phe Gly Thr Ser Ser Ile Thr Gly Asp Leu Ser Asp Asn His Asp 250 255 260 265 gtc att tcc ttg aag ttg ttt gaa ctg aca gtg gag aga acc cca gaa 867 Val Ile Ser Leu Lys Leu Phe Glu Leu Thr Val Glu Arg Thr Pro Glu 270 275 280 gag gaa aag ctc cat cga ggt gtg ttc ttg ccc tca gtg gac aat atg 915 Glu Glu Lys Leu His Arg Gly Val Phe Leu Pro Ser Val Asp Asn Met 285 290 295 aag ctg cct gag atg aca gct cca ctg ccg ccc ctg agt ggc ctg gcc 963 Lys Leu Pro Glu Met Thr Ala Pro Leu Pro Pro Leu Ser Gly Leu Ala 300 305 310 ctc ttc ctc atc gtc ttt ttc tcc ctg gtg ttt tct gta ttt gcc ata 1011 Leu Phe Leu Ile Val Phe Phe Ser Leu Val Phe Ser Val Phe Ala Ile 315 320 325 gtc att ggt atc ata ctc tac aac aaa tgg cag gaa cag agc cga aag 1059 Val Ile Gly Ile Ile Leu Tyr Asn Lys Trp Gln Glu Gln Ser Arg Lys 330 335 340 345 cgc ttc tac tgagccctcc tgctgccacc acttttgtga ctgtcaccca 1108 Arg Phe Tyr tgaggtatgg aaggagcagg cactggcctg agcatgcagc ctggagagtg ttcttgtctc 1168 tagcagctgg ttggggacta tattctgtca ctggagtttt gaatgcaggg accccgcatt 1228 cccatggttg tgcatgggga catctaactc tggtctggga agccacccac cccagggcaa 1288 tgctgctgtg atgtgccttt ccctgcagtc cttccatgtg ggagcagagg tgtgaagaga 1348 atttacgtgg ttgtgatgcc aaaatcacag aacagaattt catagcccag gctgccgtgt 1408 tgtttgactc agaaggccct tctacttcag ttttgaatcc acaaagaatt aaaaactggt 1468 aacaccacag gctttctgac catccattcg ttgggttttg catttgaccc aaccctctgc 1528 ctacctgagg agctttcttt ggaaaccagg atggaaactt cttccctgcc ttaccttcct 1588 ttcactccat tcattgtcct ctctgtgtgc aacctgagct gggaaaggca tttggatgcc 1648 tctctgttgg ggcctggggc tgcagaacac acctgcgttt cactggcctt cattaggtgg 1708 ccctagggag atggctttct gctttggatc actgttccct agcatgggtc ttgggtctat 1768 tggcatgtcc atggccttcc caatcaagtc tcttcaggcc ctcagttaag tttggctaaa 1828 ggttggtgta aaaatcaaga gaagcctgga agacatcatg gatgccatgg attagctgtg 1888 caactgacca gctccaggtt tgatcaaacc aaaagcaaca tttgtcatgt ggtctgacca 1948 tgtggagatg tttctggact tgctagagcc tgcttagctg catgttttgt agttacgatt 2008 tttggaatcc cactttgagt gctgaaagtg taaggaagct ttcttcttac accttgggct 2068 tggatattgc ccagagaaga aatttggctt tttttttctt aatggacaag agacagttgc 2128 tgttctcatg ttccaagtct gagagcaaca gaccctcatc atctgtgcct ggaagagttc 2188 actgtcattg agcagcacag cctgagtgct ggcctctgtc aacccttatt ccactgcctt 2248 atttgacaag gggttacatg ctgctcacct tactgccctg ggattaaatc agttacaggc 2308 cagagtctcc ttggagggcc tggaactctg agtcctccta tgaacctctg tagcctaaat 2368 gaaattctta aaatcaccga tggaacc 2395 <210> 22 <211> 348 <212> PRT <213> Homo sapiens <400> 22 Met Ala Ala Ala Leu Gly Pro Leu Gly Ser Trp Gln Gln Trp Arg Arg 1 5 10 15 Cys Leu Ser Ala Arg Asp Gly Ser Arg Met Leu Leu Leu Leu Leu Leu 20 25 30 Leu Gly Ser Gly Gln Gly Pro Gln Gln Val Gly Ala Gly Gln Thr Phe 35 40 45 Glu Tyr Leu Lys Arg Glu His Ser Leu Ser Lys Pro Tyr Gln Gly Val 50 55 60 Gly Thr Gly Ser Ser Ser Leu Trp Asn Leu Met Gly Asn Ala Met Val 65 70 75 80 Met Thr Gln Tyr Ile Arg Leu Thr Pro Asp Met Gln Ser Lys Gln Gly 85 90 95 Ala Leu Trp Asn Arg Val Pro Cys Phe Leu Arg Asp Trp Glu Leu Gln 100 105 110 Val His Phe Lys Ile His Gly Gln Gly Lys Lys Asn Leu His Gly Asp 115 120 125 Gly Leu Ala Ile Trp Tyr Thr Lys Asp Arg Met Gln Pro Gly Pro Val 130 135 140 Phe Gly Asn Met Asp Lys Phe Val Gly Leu Gly Val Phe Val Asp Thr 145 150 155 160 Tyr Pro Asn Glu Glu Lys Gln Gln Glu Arg Val Phe Pro Tyr Ile Ser 165 170 175 Ala Met Val Asn Asn Gly Ser Leu Ser Tyr Asp His Glu Arg Asp Gly 180 185 190 Arg Pro Thr Glu Leu Gly Gly Cys Thr Ala Ile Val Arg Asn Leu His 195 200 205 Tyr Asp Thr Phe Leu Val Ile Arg Tyr Val Lys Arg His Leu Thr Ile 210 215 220 Met Met Asp Ile Asp Gly Lys His Glu Trp Arg Asp Cys Ile Glu Val 225 230 235 240 Pro Gly Val Arg Leu Pro Arg Gly Tyr Tyr Phe Gly Thr Ser Ser Ile 245 250 255 Thr Gly Asp Leu Ser Asp Asn His Asp Val Ile Ser Leu Lys Leu Phe 260 265 270 Glu Leu Thr Val Glu Arg Thr Pro Glu Glu Glu Lys Leu His Arg Gly 275 280 285 Val Phe Leu Pro Ser Val Asp Asn Met Lys Leu Pro Glu Met Thr Ala 290 295 300 Pro Leu Pro Pro Leu Ser Gly Leu Ala Leu Phe Leu Ile Val Phe Phe 305 310 315 320 Ser Leu Val Phe Ser Val Phe Ala Ile Val Ile Gly Ile Ile Leu Tyr 325 330 335 Asn Lys Trp Gln Glu Gln Ser Arg Lys Arg Phe Tyr 340 345 <210> 23 <211> 1683 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (118)..(1017) <400> 23 agttcctcct tgctctcgcc cctactcttt ctggtgttag atcgagcaac cctctaaaag 60 cagtttagag tggtaaaaaa aaaaaaaaca caccaaacgc tcgcagccac aaaaggg 117 atg aaa ttt ctt ctg gac atc ctc ctg ctt ctc ccg tta ctg atc gtc 165 Met Lys Phe Leu Leu Asp Ile Leu Leu Leu Leu Pro Leu Leu Ile Val 1 5 10 15 tgc tcc cta gag tcc ttc gtg aag ctt ttt att cct aag agg aga aaa 213 Cys Ser Leu Glu Ser Phe Val Lys Leu Phe Ile Pro Lys Arg Arg Lys 20 25 30 tca gtc acc ggc gaa acc gtg ctg att aca gga gct ggg cat gga att 261 Ser Val Thr Gly Glu Thr Val Leu Ile Thr Gly Ala Gly His Gly Ile 35 40 45 ggg aga ctg act gcc tat gaa ttt gct aaa ctt aaa agc aag ctg gtt 309 Gly Arg Leu Thr Ala Tyr Glu Phe Ala Lys Leu Lys Ser Lys Leu Val 50 55 60 ctc tgg gat ata aat aag cat gga ctg gag gaa aca gct gcc aaa tgc 357 Leu Trp Asp Ile Asn Lys His Gly Leu Glu Glu Thr Ala Ala Lys Cys 65 70 75 80 aag gga ctg ggt gcc aag gtt cat acc ttt gtg gta gac tgc agc aac 405 Lys Gly Leu Gly Ala Lys Val His Thr Phe Val Val Asp Cys Ser Asn 85 90 95 cga gaa gat att tac agc tct gca aag aag gtg aag gca gaa att gga 453 Arg Glu Asp Ile Tyr Ser Ser Ala Lys Lys Val Lys Ala Glu Ile Gly 100 105 110 gat gtt agt att tta gta aat aat gct ggt gta gtc tat aca tca gat 501 Asp Val Ser Ile Leu Val Asn Asn Ala Gly Val Val Tyr Thr Ser Asp 115 120 125 ttg ttt gct aca caa gat cct cag att gaa aag act ttt gaa gtt aat 549 Leu Phe Ala Thr Gln Asp Pro Gln Ile Glu Lys Thr Phe Glu Val Asn 130 135 140 gta ctt gca cat ttc tgg act aca aag gca ttt ctt cct gca atg acg 597 Val Leu Ala His Phe Trp Thr Thr Lys Ala Phe Leu Pro Ala Met Thr 145 150 155 160 aag aat aac cat ggc cat att gtc act gtg gct tcg gca gct gga cat 645 Lys Asn Asn His Gly His Ile Val Thr Val Ala Ser Ala Ala Gly His 165 170 175 gtc tcg gtc ccc ttc tta ctg gct tac tgt tca agc aag ttt gct gct 693 Val Ser Val Pro Phe Leu Leu Ala Tyr Cys Ser Ser Lys Phe Ala Ala 180 185 190 gtt gga ttt cat aaa act ttg aca gat gaa ctg gct gcc tta caa ata 741 Val Gly Phe His Lys Thr Leu Thr Asp Glu Leu Ala Ala Leu Gln Ile 195 200 205 act gga gtc aaa aca aca tgt ctg tgt cct aat ttc gta aac act ggc 789 Thr Gly Val Lys Thr Thr Cys Leu Cys Pro Asn Phe Val Asn Thr Gly 210 215 220 ttc atc aaa aat cca agt aca agt ttg gga ccc act ctg gaa cct gag 837 Phe Ile Lys Asn Pro Ser Thr Ser Leu Gly Pro Thr Leu Glu Pro Glu 225 230 235 240 gaa gtg gta aac agg ctg atg cat ggg att ctg act gag cag aag atg 885 Glu Val Val Asn Arg Leu Met His Gly Ile Leu Thr Glu Gln Lys Met 245 250 255 att ttt att cca tct tct ata gct ttt tta aca aca ttg gaa agg atc 933 Ile Phe Ile Pro Ser Ser Ile Ala Phe Leu Thr Thr Leu Glu Arg Ile 260 265 270 ctt cct gag cgt ttc ctg gca gtt tta aaa cga aaa atc agt gtt aag 981 Leu Pro Glu Arg Phe Leu Ala Val Leu Lys Arg Lys Ile Ser Val Lys 275 280 285 ttt gat gca gtt att gga tat aaa atg aaa gcg caa taagcaccta 1027 Phe Asp Ala Val Ile Gly Tyr Lys Met Lys Ala Gln 290 295 300 gttttctgaa aactgattta ccaggtttag gttgatgtca tctaatagtg ccagaatttt 1087 aatgtttgaa cttctgtttt ttctaattat ccccatttct tcaatatcat ttttgaggct 1147 ttggcagtct tcatttacta ccacttgttc tttagccaaa agctgattac atatgatata 1207 aacagagaaa tacctttaga ggtgacttta aggaaaatga agaaaaagaa ccaaaatgac 1267 tttattaaaa taatttccaa gattatttgt ggctcacctg aaggctttgc aaaatttgta 1327 ccataaccgt ttatttaaca tatattttta tttttgattg cacttaaatt ttgtataatt 1387 tgtgtttctt tttctgttct acataaaatc agaaacttca agctctctaa ataaaatgaa 1447 ggactatatc tagtggtatt tcacaatgaa tatcatgaac tctcaatggg taggtttcat 1507 cctacccatt gccactctgt ttcctgagag atacctcaca ttccaatgcc aaacatttct 1567 gcacagggaa gctagaggtg gatacacgtg ttgcaagtat aaaagcatca ctgggattta 1627 aggagaattg agagaatgta cccacaaatg gcagcaataa taaatggatc acactt 1683 <210> 24 <211> 300 <212> PRT <213> Homo sapiens <400> 24 Met Lys Phe Leu Leu Asp Ile Leu Leu Leu Leu Pro Leu Leu Ile Val 1 5 10 15 Cys Ser Leu Glu Ser Phe Val Lys Leu Phe Ile Pro Lys Arg Arg Lys 20 25 30 Ser Val Thr Gly Glu Thr Val Leu Ile Thr Gly Ala Gly His Gly Ile 35 40 45 Gly Arg Leu Thr Ala Tyr Glu Phe Ala Lys Leu Lys Ser Lys Leu Val 50 55 60 Leu Trp Asp Ile Asn Lys His Gly Leu Glu Glu Thr Ala Ala Lys Cys 65 70 75 80 Lys Gly Leu Gly Ala Lys Val His Thr Phe Val Val Asp Cys Ser Asn 85 90 95 Arg Glu Asp Ile Tyr Ser Ser Ala Lys Lys Val Lys Ala Glu Ile Gly 100 105 110 Asp Val Ser Ile Leu Val Asn Asn Ala Gly Val Val Tyr Thr Ser Asp 115 120 125 Leu Phe Ala Thr Gln Asp Pro Gln Ile Glu Lys Thr Phe Glu Val Asn 130 135 140 Val Leu Ala His Phe Trp Thr Thr Lys Ala Phe Leu Pro Ala Met Thr 145 150 155 160 Lys Asn Asn His Gly His Ile Val Thr Val Ala Ser Ala Ala Gly His 165 170 175 Val Ser Val Pro Phe Leu Leu Ala Tyr Cys Ser Ser Lys Phe Ala Ala 180 185 190 Val Gly Phe His Lys Thr Leu Thr Asp Glu Leu Ala Ala Leu Gln Ile 195 200 205 Thr Gly Val Lys Thr Thr Cys Leu Cys Pro Asn Phe Val Asn Thr Gly 210 215 220 Phe Ile Lys Asn Pro Ser Thr Ser Leu Gly Pro Thr Leu Glu Pro Glu 225 230 235 240 Glu Val Val Asn Arg Leu Met His Gly Ile Leu Thr Glu Gln Lys Met 245 250 255 Ile Phe Ile Pro Ser Ser Ile Ala Phe Leu Thr Thr Leu Glu Arg Ile 260 265 270 Leu Pro Glu Arg Phe Leu Ala Val Leu Lys Arg Lys Ile Ser Val Lys 275 280 285 Phe Asp Ala Val Ile Gly Tyr Lys Met Lys Ala Gln 290 295 300 <210> 25 <211> 1584 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (14)..(1231) <400> 25 gaattgcggc cgt atg cgc ggc tct gtg gag tgc acc tgg ggt tgg ggg 49 Met Arg Gly Ser Val Glu Cys Thr Trp Gly Trp Gly 1 5 10 cac tgt gcc ccc agc ccc ctg ctc ctt tgg act cta ctt ctg ttt gca 97 His Cys Ala Pro Ser Pro Leu Leu Leu Trp Thr Leu Leu Leu Phe Ala 15 20 25 gcc cca ttt ggc ctg ctg ggg gag aag acc cgc cag gtg tct ctg gag 145 Ala Pro Phe Gly Leu Leu Gly Glu Lys Thr Arg Gln Val Ser Leu Glu 30 35 40 gtc atc cct aac tgg ctg ggc ccc ctg cag aac ctg ctt cat ata cgg 193 Val Ile Pro Asn Trp Leu Gly Pro Leu Gln Asn Leu Leu His Ile Arg 45 50 55 60 gca gtg ggc acc aat tcc aca ctg cac tat gtg tgg agc agc ctg ggg 241 Ala Val Gly Thr Asn Ser Thr Leu His Tyr Val Trp Ser Ser Leu Gly 65 70 75 cct ctg gca gtg gta atg gtg gcc acc aac acc ccc cac agc acc ctg 289 Pro Leu Ala Val Val Met Val Ala Thr Asn Thr Pro His Ser Thr Leu 80 85 90 agc gtc aac tgg agc ctc ctg cta tcc cct gag ccc gat ggg ggc ctg 337 Ser Val Asn Trp Ser Leu Leu Leu Ser Pro Glu Pro Asp Gly Gly Leu 95 100 105 atg gtg ctc cct aag gac agc att cag ttt tct tct gcc ctt gtt ttt 385 Met Val Leu Pro Lys Asp Ser Ile Gln Phe Ser Ser Ala Leu Val Phe 110 115 120 acc agg ctg ctt gag ttt gac agc acc aac gtg tcc gat acg gca gca 433 Thr Arg Leu Leu Glu Phe Asp Ser Thr Asn Val Ser Asp Thr Ala Ala 125 130 135 140 aag cct ttg gga aga cca tat cct cca tac tcc ttg gcc gat ttc tct 481 Lys Pro Leu Gly Arg Pro Tyr Pro Pro Tyr Ser Leu Ala Asp Phe Ser 145 150 155 tgg aac aac atc act gat tca ttg gat cct gcc acc ctg agt gcc aca 529 Trp Asn Asn Ile Thr Asp Ser Leu Asp Pro Ala Thr Leu Ser Ala Thr 160 165 170 ttt caa ggc cac ccc atg aac gac cct acc agg act ttt gcc aat ggc 577 Phe Gln Gly His Pro Met Asn Asp Pro Thr Arg Thr Phe Ala Asn Gly 175 180 185 agc ctg gcc ttc agg gtc cag gcc ttt tcc agg tcc agc cga cca gcc 625 Ser Leu Ala Phe Arg Val Gln Ala Phe Ser Arg Ser Ser Arg Pro Ala 190 195 200 caa ccc cct cgc ctc ctg cac aca gca gac acc tgt cag cta gag gtg 673 Gln Pro Pro Arg Leu Leu His Thr Ala Asp Thr Cys Gln Leu Glu Val 205 210 215 220 gcc ctg att gga gcc tct ccc cgg gga aac cgt tcc ctg ttt ggg ctg 721 Ala Leu Ile Gly Ala Ser Pro Arg Gly Asn Arg Ser Leu Phe Gly Leu 225 230 235 gag gta gcc aca ttg ggc cag ggc cct gac tgc ccc tca atg cag gag 769 Glu Val Ala Thr Leu Gly Gln Gly Pro Asp Cys Pro Ser Met Gln Glu 240 245 250 cag cac tcc atc gac gat gaa tat gca ccg gcc gtc ttc cag ttg gac 817 Gln His Ser Ile Asp Asp Glu Tyr Ala Pro Ala Val Phe Gln Leu Asp 255 260 265 cag cta ctg tgg ggc tcc ctc cca tca ggc ttt gca cag tgg cga cca 865 Gln Leu Leu Trp Gly Ser Leu Pro Ser Gly Phe Ala Gln Trp Arg Pro 270 275 280 gtg gct tac tcc cag aag ccg ggg ggc cga gaa tca gcc ctg ccc tgc 913 Val Ala Tyr Ser Gln Lys Pro Gly Gly Arg Glu Ser Ala Leu Pro Cys 285 290 295 300 caa gct tcc cct ctt cat cct gcc tta gca tac tct ctt ccc cag tca 961 Gln Ala Ser Pro Leu His Pro Ala Leu Ala Tyr Ser Leu Pro Gln Ser 305 310 315 ccc att gtc cga gcc ttc ttt ggg tcc cag aat aac ttc tgt gcc ttc 1009 Pro Ile Val Arg Ala Phe Phe Gly Ser Gln Asn Asn Phe Cys Ala Phe 320 325 330 aat ctg acg ttc ggg gct tcc aca ggc cct ggc tat tgg gac caa cac 1057 Asn Leu Thr Phe Gly Ala Ser Thr Gly Pro Gly Tyr Trp Asp Gln His 335 340 345 tac ctc agc tgg tcg atg ctc ctt ggt gtg ggc ttc cct cca gtg gac 1105 Tyr Leu Ser Trp Ser Met Leu Leu Gly Val Gly Phe Pro Pro Val Asp 350 355 360 ggc ttg tcc cca cta gtc ctg ggc atc atg gca gtg gcc ctg ggt gcc 1153 Gly Leu Ser Pro Leu Val Leu Gly Ile Met Ala Val Ala Leu Gly Ala 365 370 375 380 cca ggg ctc atg ctg cta ggg ggc ggc ttg gtt ctg ctg ctg cac cac 1201 Pro Gly Leu Met Leu Leu Gly Gly Gly Leu Val Leu Leu Leu His His 385 390 395 aag aag tac tca gag tac cag tcc ata aat taaggcccgc tctctggagg 1251 Lys Lys Tyr Ser Glu Tyr Gln Ser Ile Asn 400 405 gaaggacatt actgaacctg tcttgctgtg cctcgaaact ctggaggttg gagcatcaag 1311 ttccagccgg ccccttcact cccccatctt gcttttctgt ggaacctcag aggccagcct 1371 cgacttcctg gagaccccca ggtggggctt ccttcatact ttgttggggg actttggagg 1431 cgggcagggg acagggctat tgataaggtc cccttggtgt tgccttcttg catctccaca 1491 catttccctt ggatgggact tgcaggccta aatgagaggc attctgactg gttggctgcc 1551 ctggaaggca agaaaataga tttatttttt ttc 1584 <210> 26 <211> 406 <212> PRT <213> Homo sapiens <400> 26 Met Arg Gly Ser Val Glu Cys Thr Trp Gly Trp Gly His Cys Ala Pro 1 5 10 15 Ser Pro Leu Leu Leu Trp Thr Leu Leu Leu Phe Ala Ala Pro Phe Gly 20 25 30 Leu Leu Gly Glu Lys Thr Arg Gln Val Ser Leu Glu Val Ile Pro Asn 35 40 45 Trp Leu Gly Pro Leu Gln Asn Leu Leu His Ile Arg Ala Val Gly Thr 50 55 60 Asn Ser Thr Leu His Tyr Val Trp Ser Ser Leu Gly Pro Leu Ala Val 65 70 75 80 Val Met Val Ala Thr Asn Thr Pro His Ser Thr Leu Ser Val Asn Trp 85 90 95 Ser Leu Leu Leu Ser Pro Glu Pro Asp Gly Gly Leu Met Val Leu Pro 100 105 110 Lys Asp Ser Ile Gln Phe Ser Ser Ala Leu Val Phe Thr Arg Leu Leu 115 120 125 Glu Phe Asp Ser Thr Asn Val Ser Asp Thr Ala Ala Lys Pro Leu Gly 130 135 140 Arg Pro Tyr Pro Pro Tyr Ser Leu Ala Asp Phe Ser Trp Asn Asn Ile 145 150 155 160 Thr Asp Ser Leu Asp Pro Ala Thr Leu Ser Ala Thr Phe Gln Gly His 165 170 175 Pro Met Asn Asp Pro Thr Arg Thr Phe Ala Asn Gly Ser Leu Ala Phe 180 185 190 Arg Val Gln Ala Phe Ser Arg Ser Ser Arg Pro Ala Gln Pro Pro Arg 195 200 205 Leu Leu His Thr Ala Asp Thr Cys Gln Leu Glu Val Ala Leu Ile Gly 210 215 220 Ala Ser Pro Arg Gly Asn Arg Ser Leu Phe Gly Leu Glu Val Ala Thr 225 230 235 240 Leu Gly Gln Gly Pro Asp Cys Pro Ser Met Gln Glu Gln His Ser Ile 245 250 255 Asp Asp Glu Tyr Ala Pro Ala Val Phe Gln Leu Asp Gln Leu Leu Trp 260 265 270 Gly Ser Leu Pro Ser Gly Phe Ala Gln Trp Arg Pro Val Ala Tyr Ser 275 280 285 Gln Lys Pro Gly Gly Arg Glu Ser Ala Leu Pro Cys Gln Ala Ser Pro 290 295 300 Leu His Pro Ala Leu Ala Tyr Ser Leu Pro Gln Ser Pro Ile Val Arg 305 310 315 320 Ala Phe Phe Gly Ser Gln Asn Asn Phe Cys Ala Phe Asn Leu Thr Phe 325 330 335 Gly Ala Ser Thr Gly Pro Gly Tyr Trp Asp Gln His Tyr Leu Ser Trp 340 345 350 Ser Met Leu Leu Gly Val Gly Phe Pro Pro Val Asp Gly Leu Ser Pro 355 360 365 Leu Val Leu Gly Ile Met Ala Val Ala Leu Gly Ala Pro Gly Leu Met 370 375 380 Leu Leu Gly Gly Gly Leu Val Leu Leu Leu His His Lys Lys Tyr Ser 385 390 395 400 Glu Tyr Gln Ser Ile Asn 405 <210> 27 <211> 1336 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (94)..(501) <400> 27 atactgagtt gtttaggact ttctattgtg gcaaacttcc agaaaacaac cctttttgct 60 gcacatgtaa gtggagctgt gcttaccttt ggt atg ggc tca tta tat atg ttt 114 Met Gly Ser Leu Tyr Met Phe 1 5 gtt cag acc atc ctt tcc tac caa atg cag ccc aaa atc cat ggc aaa 162 Val Gln Thr Ile Leu Ser Tyr Gln Met Gln Pro Lys Ile His Gly Lys 10 15 20 caa gtc ttc tgg atc aga ctg ttg ttg gtt atc tgg tgt gga gta agt 210 Gln Val Phe Trp Ile Arg Leu Leu Leu Val Ile Trp Cys Gly Val Ser 25 30 35 gca ctt agc atg ctg act tgc tca tca gtt ttg cac agt ggc aat ttt 258 Ala Leu Ser Met Leu Thr Cys Ser Ser Val Leu His Ser Gly Asn Phe 40 45 50 55 ggg act gat tta gaa cag aaa ctc cat tgg aac ccc gag gac aaa ggt 306 Gly Thr Asp Leu Glu Gln Lys Leu His Trp Asn Pro Glu Asp Lys Gly 60 65 70 tat gtg ctt cac atg atc act act gca gca gaa tgg tct atg tca ttt 354 Tyr Val Leu His Met Ile Thr Thr Ala Ala Glu Trp Ser Met Ser Phe 75 80 85 tcc ttc ttt ggt ttt ttc ctg act tac att cgt gat ttt cag aaa att 402 Ser Phe Phe Gly Phe Phe Leu Thr Tyr Ile Arg Asp Phe Gln Lys Ile 90 95 100 tct tta cgg gtg gaa gcc aat tta cat gga tta acc ctc tat gac act 450 Ser Leu Arg Val Glu Ala Asn Leu His Gly Leu Thr Leu Tyr Asp Thr 105 110 115 gca cct tgc cct att aac aat gaa cga aca cgg cta ctt tcc aga gat 498 Ala Pro Cys Pro Ile Asn Asn Glu Arg Thr Arg Leu Leu Ser Arg Asp 120 125 130 135 att tgatgaaagg ataaaatatt tctgtaatga ttatgattct cagggattgg 551 Ile ggaaaggttc acagaagttg cttatttttc tctgaaattt tcaaccactt aatcaaggct 611 gacagtaaca ctgatgaatg ctgataatca ggaaacatga aagaagccat ttgatagatt 671 attctaaagg atatcatcaa gaagactatt aaaaacacct atgcctatac ttttttatct 731 cagaaaataa agtcaaaaga ctatgatatc atagttttta taccttattt aaggaggaaa 791 caacctgacg tggcaccaat cagttctggc acatcccaac ccttcacatt ttataaatta 851 ttgtagatca tgttttgtta ggagcacttt tatgagagac attttccatg actaaataat 911 cagcattagt cagtaaatcc tttagaactg ggttttgaaa tgggagtttt atcatattaa 971 atcatttctt gtagtcttac attttttgtt gttgttctgg aatctacctg taaaggaaag 1031 tagacctgga ttcatgtggg ctcttccatg gcttaagtgt tgcccaagag attttgtagg 1091 taacgatttt ttttttttct ggccacaatg ccagatacta agctaattgg tctatcatac 1151 acatgcttgc agtagtttca tgaagtttag tctctggcgt gaaattttaa tcaccaatga 1211 aggagagagg cacctgtagg taaatttact ttagtcatat tttatataaa acaagggtta 1271 gtattcatgt aacattgaga agtttgggaa taacagcaga tatgattaat aaaagtcata 1331 accat 1336 <210> 28 <211> 136 <212> PRT <213> Homo sapiens <400> 28 Met Gly Ser Leu Tyr Met Phe Val Gln Thr Ile Leu Ser Tyr Gln Met 1 5 10 15 Gln Pro Lys Ile His Gly Lys Gln Val Phe Trp Ile Arg Leu Leu Leu 20 25 30 Val Ile Trp Cys Gly Val Ser Ala Leu Ser Met Leu Thr Cys Ser Ser 35 40 45 Val Leu His Ser Gly Asn Phe Gly Thr Asp Leu Glu Gln Lys Leu His 50 55 60 Trp Asn Pro Glu Asp Lys Gly Tyr Val Leu His Met Ile Thr Thr Ala 65 70 75 80 Ala Glu Trp Ser Met Ser Phe Ser Phe Phe Gly Phe Phe Leu Thr Tyr 85 90 95 Ile Arg Asp Phe Gln Lys Ile Ser Leu Arg Val Glu Ala Asn Leu His 100 105 110 Gly Leu Thr Leu Tyr Asp Thr Ala Pro Cys Pro Ile Asn Asn Glu Arg 115 120 125 Thr Arg Leu Leu Ser Arg Asp Ile 130 135 <210> 29 <211> 1729 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (29)..(1246) <400> 29 ctactctggc accactctcc aggctgcc atg ggg ccc agc acc cct ctc ctc 52 Met Gly Pro Ser Thr Pro Leu Leu 1 5 atc ttg ttc ctt ttg tca tgg tcg gga ccc ctc caa gga cag cag cac 100 Ile Leu Phe Leu Leu Ser Trp Ser Gly Pro Leu Gln Gly Gln Gln His 10 15 20 cac ctt gtg gag tac atg gaa cgc cga cta gct gct tta gag gaa cgg 148 His Leu Val Glu Tyr Met Glu Arg Arg Leu Ala Ala Leu Glu Glu Arg 25 30 35 40 ctg gcc cag tgc cag gac cag agt agt cgg cat gct gct gag ctg cgg 196 Leu Ala Gln Cys Gln Asp Gln Ser Ser Arg His Ala Ala Glu Leu Arg 45 50 55 gac ttc aag aac aag atg ctg cca ctg ctg gag gtg gca gag aag gag 244 Asp Phe Lys Asn Lys Met Leu Pro Leu Leu Glu Val Ala Glu Lys Glu 60 65 70 cgg gag gca ctc aga act gag gcc gac acc atc tcc ggg aga gtg gat 292 Arg Glu Ala Leu Arg Thr Glu Ala Asp Thr Ile Ser Gly Arg Val Asp 75 80 85 cgt ctg gag cgg gag gta gac tat ctg gag acc cag aac cca gct ctg 340 Arg Leu Glu Arg Glu Val Asp Tyr Leu Glu Thr Gln Asn Pro Ala Leu 90 95 100 ccc tgt gta gag ttt gat gag aag gtg act gga ggc cct ggg acc aaa 388 Pro Cys Val Glu Phe Asp Glu Lys Val Thr Gly Gly Pro Gly Thr Lys 105 110 115 120 ggc aag gga aga agg aat gag aag tac gat atg gtg aca gac tgt ggc 436 Gly Lys Gly Arg Arg Asn Glu Lys Tyr Asp Met Val Thr Asp Cys Gly 125 130 135 tac aca atc tct caa gtg aga tca atg aag att ctg aag cga ttt ggt 484 Tyr Thr Ile Ser Gln Val Arg Ser Met Lys Ile Leu Lys Arg Phe Gly 140 145 150 ggc cca gct ggt cta tgg acc aag gat cca ctg ggg caa aca gag aag 532 Gly Pro Ala Gly Leu Trp Thr Lys Asp Pro Leu Gly Gln Thr Glu Lys 155 160 165 atc tac gtg tta gat ggg aca cag aat gac aca gcc ttt gtc ttc cca 580 Ile Tyr Val Leu Asp Gly Thr Gln Asn Asp Thr Ala Phe Val Phe Pro 170 175 180 agg ctg cgt gac ttc acc ctt gcc atg gct gcc cgg aaa gct tcc cga 628 Arg Leu Arg Asp Phe Thr Leu Ala Met Ala Ala Arg Lys Ala Ser Arg 185 190 195 200 gtc cgg gtg ccc ttc ccc tgg gta ggc aca ggg cag ctg gta tat ggt 676 Val Arg Val Pro Phe Pro Trp Val Gly Thr Gly Gln Leu Val Tyr Gly 205 210 215 ggc ttt ctt tat ttt gct cgg agg cct cct gga aga cct ggt gga ggt 724 Gly Phe Leu Tyr Phe Ala Arg Arg Pro Pro Gly Arg Pro Gly Gly Gly 220 225 230 ggt gag atg gag aac act ttg cag cta atc aaa ttc cac ctg gca aac 772 Gly Glu Met Glu Asn Thr Leu Gln Leu Ile Lys Phe His Leu Ala Asn 235 240 245 cga aca gtg gtg gac agc tca gta ttc cca gca gag ggg ctg atc ccc 820 Arg Thr Val Val Asp Ser Ser Val Phe Pro Ala Glu Gly Leu Ile Pro 250 255 260 ccc tac ggc ttg aca gca gac acc tac atc gac ctg gca gct gat gag 868 Pro Tyr Gly Leu Thr Ala Asp Thr Tyr Ile Asp Leu Ala Ala Asp Glu 265 270 275 280 gaa ggt ctt tgg gct gtc tat gcc acc cgg gag gat gac agg cac ttg 916 Glu Gly Leu Trp Ala Val Tyr Ala Thr Arg Glu Asp Asp Arg His Leu 285 290 295 tgt ctg gcc aag tta gat cca cag aca ctg gac aca gag cag cag tgg 964 Cys Leu Ala Lys Leu Asp Pro Gln Thr Leu Asp Thr Glu Gln Gln Trp 300 305 310 gac aca cca tgt ccc aga gag aat gct gag gct gcc ttt gtc atc tgt 1012 Asp Thr Pro Cys Pro Arg Glu Asn Ala Glu Ala Ala Phe Val Ile Cys 315 320 325 ggg acc ctc tat gtt gtc tat aac acc cgt cct gcc agt cgg gcc cgc 1060 Gly Thr Leu Tyr Val Val Tyr Asn Thr Arg Pro Ala Ser Arg Ala Arg 330 335 340 atc cag tgc tcc ttt gat gcc agc ggc acc ctg acc cct gaa cgg gca 1108 Ile Gln Cys Ser Phe Asp Ala Ser Gly Thr Leu Thr Pro Glu Arg Ala 345 350 355 360 gca ctc cct tat ttt ccc cgc aga tat ggt gcc cat gcc agc ctc cgc 1156 Ala Leu Pro Tyr Phe Pro Arg Arg Tyr Gly Ala His Ala Ser Leu Arg 365 370 375 tat aac ccc cga gaa cgc cag ctc tat gcc tgg gat gat ggc tac cag 1204 Tyr Asn Pro Arg Glu Arg Gln Leu Tyr Ala Trp Asp Asp Gly Tyr Gln 380 385 390 att gtc tat aag ctg gag atg agg aag aaa gag gag gag gtt 1246 Ile Val Tyr Lys Leu Glu Met Arg Lys Lys Glu Glu Glu Val 395 400 405 tgaggagcta gccttgtttt ttgcatcttt ctcactccca tacatttata ttatatcccc 1306 actaaatttc ttgttcctca ttcttcaaat gtgggccagt tgtggctcaa atcctctata 1366 tttttagcca atggcaatca aattctttca gctcctttgt ttcatacgga actccagatc 1426 ctgagtaatc cttttagagc ccgaagagtc aaaaccctca atgttccctc ctgctctcct 1486 gccccatgtc aacaaatttc aggctaagga tgccccagac ccagggctct aaccttgtat 1546 gcgggcaggc ccagggagca ggcagcagtg ttcttcccct cagagtgact tggggaggga 1606 gaaataggag gggacgtcca gctctgtcct ctcttcctca ctcctccctt cagtgtcctg 1666 aggaacagga ctttctccac attgttttgt attgcaacat tttgcattaa aaggaaaatc 1726 cac 1729 <210> 30 <211> 406 <212> PRT <213> Homo sapiens <400> 30 Met Gly Pro Ser Thr Pro Leu Leu Ile Leu Phe Leu Leu Ser Trp Ser 1 5 10 15 Gly Pro Leu Gln Gly Gln Gln His His Leu Val Glu Tyr Met Glu Arg 20 25 30 Arg Leu Ala Ala Leu Glu Glu Arg Leu Ala Gln Cys Gln Asp Gln Ser 35 40 45 Ser Arg His Ala Ala Glu Leu Arg Asp Phe Lys Asn Lys Met Leu Pro 50 55 60 Leu Leu Glu Val Ala Glu Lys Glu Arg Glu Ala Leu Arg Thr Glu Ala 65 70 75 80 Asp Thr Ile Ser Gly Arg Val Asp Arg Leu Glu Arg Glu Val Asp Tyr 85 90 95 Leu Glu Thr Gln Asn Pro Ala Leu Pro Cys Val Glu Phe Asp Glu Lys 100 105 110 Val Thr Gly Gly Pro Gly Thr Lys Gly Lys Gly Arg Arg Asn Glu Lys 115 120 125 Tyr Asp Met Val Thr Asp Cys Gly Tyr Thr Ile Ser Gln Val Arg Ser 130 135 140 Met Lys Ile Leu Lys Arg Phe Gly Gly Pro Ala Gly Leu Trp Thr Lys 145 150 155 160 Asp Pro Leu Gly Gln Thr Glu Lys Ile Tyr Val Leu Asp Gly Thr Gln 165 170 175 Asn Asp Thr Ala Phe Val Phe Pro Arg Leu Arg Asp Phe Thr Leu Ala 180 185 190 Met Ala Ala Arg Lys Ala Ser Arg Val Arg Val Pro Phe Pro Trp Val 195 200 205 Gly Thr Gly Gln Leu Val Tyr Gly Gly Phe Leu Tyr Phe Ala Arg Arg 210 215 220 Pro Pro Gly Arg Pro Gly Gly Gly Gly Glu Met Glu Asn Thr Leu Gln 225 230 235 240 Leu Ile Lys Phe His Leu Ala Asn Arg Thr Val Val Asp Ser Ser Val 245 250 255 Phe Pro Ala Glu Gly Leu Ile Pro Pro Tyr Gly Leu Thr Ala Asp Thr 260 265 270 Tyr Ile Asp Leu Ala Ala Asp Glu Glu Gly Leu Trp Ala Val Tyr Ala 275 280 285 Thr Arg Glu Asp Asp Arg His Leu Cys Leu Ala Lys Leu Asp Pro Gln 290 295 300 Thr Leu Asp Thr Glu Gln Gln Trp Asp Thr Pro Cys Pro Arg Glu Asn 305 310 315 320 Ala Glu Ala Ala Phe Val Ile Cys Gly Thr Leu Tyr Val Val Tyr Asn 325 330 335 Thr Arg Pro Ala Ser Arg Ala Arg Ile Gln Cys Ser Phe Asp Ala Ser 340 345 350 Gly Thr Leu Thr Pro Glu Arg Ala Ala Leu Pro Tyr Phe Pro Arg Arg 355 360 365 Tyr Gly Ala His Ala Ser Leu Arg Tyr Asn Pro Arg Glu Arg Gln Leu 370 375 380 Tyr Ala Trp Asp Asp Gly Tyr Gln Ile Val Tyr Lys Leu Glu Met Arg 385 390 395 400 Lys Lys Glu Glu Glu Val 405 <210> 31 <211> 1883 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (19)..(687) <400> 31 accgagttgt cttttgac atg tgg gga ctc gtc agc gcc ctc gcc gcc acg 51 Met Trp Gly Leu Val Ser Ala Leu Ala Ala Thr 1 5 10 ctg tgc ttc tcg ctt cag aac att ttc tcc aaa aag gtc ttg cga gat 99 Leu Cys Phe Ser Leu Gln Asn Ile Phe Ser Lys Lys Val Leu Arg Asp 15 20 25 tca cgg atc cac cat ctc cgg ctg ctc aac atc ctg ggc tgc cac gcc 147 Ser Arg Ile His His Leu Arg Leu Leu Asn Ile Leu Gly Cys His Ala 30 35 40 gtc ttc ttt atg atc ccc acc tgg gtt ctg gtg gac ctc tcg gct ttc 195 Val Phe Phe Met Ile Pro Thr Trp Val Leu Val Asp Leu Ser Ala Phe 45 50 55 ctg gtc agc agc gac ttg acc tac gtc tac cag tgg ccc tgg acg ctc 243 Leu Val Ser Ser Asp Leu Thr Tyr Val Tyr Gln Trp Pro Trp Thr Leu 60 65 70 75 ctg ctc ctg gct gtc agc ggc ttc tgt aac ttt gcc cag aat gtt atc 291 Leu Leu Leu Ala Val Ser Gly Phe Cys Asn Phe Ala Gln Asn Val Ile 80 85 90 gcc ttc agc atc ctc aac ctc gtt agc ccc ctg agc tac tcg gtc gcc 339 Ala Phe Ser Ile Leu Asn Leu Val Ser Pro Leu Ser Tyr Ser Val Ala 95 100 105 aat gcc acc aaa aga atc atg gtc atc acg gtg tcc ctg atc atg ctg 387 Asn Ala Thr Lys Arg Ile Met Val Ile Thr Val Ser Leu Ile Met Leu 110 115 120 cgc aac cca gtc acc agc acc atc gtc ctg ggc atg atg acc gcc atc 435 Arg Asn Pro Val Thr Ser Thr Ile Val Leu Gly Met Met Thr Ala Ile 125 130 135 ctg ggg gtc ttc ctc tat aac aag acc aag tac gat gca aac cag caa 483 Leu Gly Val Phe Leu Tyr Asn Lys Thr Lys Tyr Asp Ala Asn Gln Gln 140 145 150 155 gcc agg aag cac ctc ctc ccc gtc acc aca gca gac ctg agc agc aag 531 Ala Arg Lys His Leu Leu Pro Val Thr Thr Ala Asp Leu Ser Ser Lys 160 165 170 gag cgt cac cgg agc cca ctg gag aag ccc cac aac ggc ctc ctc ttc 579 Glu Arg His Arg Ser Pro Leu Glu Lys Pro His Asn Gly Leu Leu Phe 175 180 185 ccc cag cac ggg gac tat cag tac ggc cgc aac aac atc tta aca gac 627 Pro Gln His Gly Asp Tyr Gln Tyr Gly Arg Asn Asn Ile Leu Thr Asp 190 195 200 cac ttc caa tac agc cgg cag agc tac cca aac tcg tac agt ttg aac 675 His Phe Gln Tyr Ser Arg Gln Ser Tyr Pro Asn Ser Tyr Ser Leu Asn 205 210 215 cgc tat gat gtg tagagtccaa aggacaggac cagactgttg gtgactcctt 727 Arg Tyr Asp Val 220 ccccggcccc cacagcagta tcagaaactt ctgacaatca gtgaatgtac aacccagccg 787 aggggacggt gcataactct ccatcagaag ccctggggtt cctggccccc cgtgagccgc 847 aggaggatgc gttgcctgca gtgcagacgg ccgtgagctc tgggcaaacc taaacagaga 907 ccagtgtctc atgctctttc ttcctggagt ctgtcatctg agggccgtgt ccctgcggag 967 atcttggcca cgttgtacct ttccatgtgg aattattccc caagcagtgt agctcagagc 1027 acttgtgtct gcattccaga taacattcag gacctgtgtg aaaagctggg gtcactgtgg 1087 ctgtagacca tgaactggca gtgggggtgt ccagggcggt gcttgagaac gtcagactgg 1147 ctagtttaat tccctggcgc agatacgcat aggaccaaca gggtcaccaa gcagacaggg 1207 agcccgcgag aatcattcaa aacatcccca gccacagaga tggatccagt ttcctggtca 1267 tccccttagc agttcacaag ttcctggcaa atgttccaaa gcaaaaagcg attgcaatta 1327 gcatccagtt cctgcagcct ggtgctctgc cctgcacgtc agggttggca tccacccaga 1387 tccagatgga agggaaactt ctctcttctc ctttgcctcc tcttccctca ccagagcagg 1447 gcgcttctct tggggtggtg agaaggatct tcgagaaatc gtgttcagta tttcaagctc 1507 tatttctgtg gcacatgtct tttgagaggc atcttcacct cttctgtgat gacttggtat 1567 gttgtttggt agagagatct tgattttcgg aggatcttgc atttttctag ggaatatttt 1627 gtagttgtgt gtgtgtgttt ttgccttggt ccccattatg ggatgcatta ggactggcct 1687 atgcatcgaa aatctttttg tttgtaaacg tttaaaaaca aagttccccg gccaggcaca 1747 gtggctcaca cctgtaatcc cagctacttg ggaggctgag gcaggagaat cacttgagcc 1807 caggaggtgg aggtttcagc gagctgagat cacaccactg cactccagcc ttggtgacag 1867 agtgagactc tgtctc 1883 <210> 32 <211> 223 <212> PRT <213> Homo sapiens <400> 32 Met Trp Gly Leu Val Ser Ala Leu Ala Ala Thr Leu Cys Phe Ser Leu 1 5 10 15 Gln Asn Ile Phe Ser Lys Lys Val Leu Arg Asp Ser Arg Ile His His 20 25 30 Leu Arg Leu Leu Asn Ile Leu Gly Cys His Ala Val Phe Phe Met Ile 35 40 45 Pro Thr Trp Val Leu Val Asp Leu Ser Ala Phe Leu Val Ser Ser Asp 50 55 60 Leu Thr Tyr Val Tyr Gln Trp Pro Trp Thr Leu Leu Leu Leu Ala Val 65 70 75 80 Ser Gly Phe Cys Asn Phe Ala Gln Asn Val Ile Ala Phe Ser Ile Leu 85 90 95 Asn Leu Val Ser Pro Leu Ser Tyr Ser Val Ala Asn Ala Thr Lys Arg 100 105 110 Ile Met Val Ile Thr Val Ser Leu Ile Met Leu Arg Asn Pro Val Thr 115 120 125 Ser Thr Ile Val Leu Gly Met Met Thr Ala Ile Leu Gly Val Phe Leu 130 135 140 Tyr Asn Lys Thr Lys Tyr Asp Ala Asn Gln Gln Ala Arg Lys His Leu 145 150 155 160 Leu Pro Val Thr Thr Ala Asp Leu Ser Ser Lys Glu Arg His Arg Ser 165 170 175 Pro Leu Glu Lys Pro His Asn Gly Leu Leu Phe Pro Gln His Gly Asp 180 185 190 Tyr Gln Tyr Gly Arg Asn Asn Ile Leu Thr Asp His Phe Gln Tyr Ser 195 200 205 Arg Gln Ser Tyr Pro Asn Ser Tyr Ser Leu Asn Arg Tyr Asp Val 210 215 220 <210> 33 <211> 2027 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (323)..(970) <400> 33 cctcctcccc tctgccctgt gctgaccagg gcctgggagc ccccgcacgg ttcagacaga 60 ggggccaggc tgaagctgga gaggaaccag cgtcacacag acggcctctg agaacttgga 120 gaccccgtta cccacccagc aggggtgtca ggacaagcat ctgctgcagg cttcagcctc 180 aggggcaaaa gggagccccg gggtcctggt gggggcaccg accacaggcc cggagggtgg 240 atgcctgcag gaagctgggc tctgtggagc ccgaggaggg gctggtggcc acaccccccg 300 gccccctggc tcggcggccc tc atg ccc gcc cta cgt cca ctc ctg ccg ctc 352 Met Pro Ala Leu Arg Pro Leu Leu Pro Leu 1 5 10 ctg ctc ctc ctc cgg ctg acc tcg ggg gct ggc ttg ctg cca ggg ctg 400 Leu Leu Leu Leu Arg Leu Thr Ser Gly Ala Gly Leu Leu Pro Gly Leu 15 20 25 ggg agc cac ccg ggc gtg tgc ccc aac cag ctc agc ccc aac ctg tgg 448 Gly Ser His Pro Gly Val Cys Pro Asn Gln Leu Ser Pro Asn Leu Trp 30 35 40 gtg gac gcc cag agc acc tgt gag cgc gag tgt agc agg gac cag gac 496 Val Asp Ala Gln Ser Thr Cys Glu Arg Glu Cys Ser Arg Asp Gln Asp 45 50 55 tgt gcg gct gct gag aag tgc tgc atc aac gtg tgt gga ctg cac agc 544 Cys Ala Ala Ala Glu Lys Cys Cys Ile Asn Val Cys Gly Leu His Ser 60 65 70 tgc gtg gca gca cgc ttc ccc ggc agc cca gct gcg ccg acg aca gcg 592 Cys Val Ala Ala Arg Phe Pro Gly Ser Pro Ala Ala Pro Thr Thr Ala 75 80 85 90 gcc tcc tgc gag ggc ttt gtg tgc cca cag cag ggc tcg gac tgc gac 640 Ala Ser Cys Glu Gly Phe Val Cys Pro Gln Gln Gly Ser Asp Cys Asp 95 100 105 atc tgg gac ggg cag ccc gtg tgc cgc tgc cgc gac cgc tgt gag aag 688 Ile Trp Asp Gly Gln Pro Val Cys Arg Cys Arg Asp Arg Cys Glu Lys 110 115 120 gag ccc agc ttc acc tgc gcc tcg gac ggc ctc acc tac tac aac cgc 736 Glu Pro Ser Phe Thr Cys Ala Ser Asp Gly Leu Thr Tyr Tyr Asn Arg 125 130 135 tgc tat atg gac gcc gag gcc tgc tgc ggg gcc tgc acc tcc aca tcg 784 Cys Tyr Met Asp Ala Glu Ala Cys Cys Gly Ala Cys Thr Ser Thr Ser 140 145 150 tgc cct gca agc acg tgc tca gct ggc cgc cca gca gcc cgg ggc cgc 832 Cys Pro Ala Ser Thr Cys Ser Ala Gly Arg Pro Ala Ala Arg Gly Arg 155 160 165 170 cgg aga cca ctg ccc gcc cca cac ctg ggg ccg cgc ccg tgc ctc ctg 880 Arg Arg Pro Leu Pro Ala Pro His Leu Gly Pro Arg Pro Cys Leu Leu 175 180 185 ccc tgt aca gca gcc cct ccc cac agg cgg tgc agg ttg ggg gta cgg 928 Pro Cys Thr Ala Ala Pro Pro His Arg Arg Cys Arg Leu Gly Val Arg 190 195 200 cca gcc tcc act gcg acg tca gcg gcc gcc cgc cgc ctg ctg 970 Pro Ala Ser Thr Ala Thr Ser Ala Ala Ala Arg Arg Leu Leu 205 210 215 tgacctggga gaagcagagt caccagcgag agaacctgat catgcgccct gatcagatgt 1030 atggcaacgt ggtggtcacc agcatcgggc agctggtgct ctacaacgcg cggcccgaag 1090 acgccggcct gtacacctgc accgcgcgca acgctgctgg gctgctgcgg gctgacttcc 1150 cactctctgt ggtccagcga gagccggcca gggacgcagc ccccagcatc ccagccccgg 1210 ccgagtgcct gccggatgtg caggcctgca cgggccccac ttccccacac cttgtcctct 1270 ggcactacga cccgcagcgg ggcggctgca tgaccttccc ggcccgtggc tgtgatgggg 1330 cggcccgcgg ctttgagacc tacgaggcat gccagcaggc ctgtgcccgc ggccccggcg 1390 acgcctgcgt gctgcctgcc gtgcagggcc cctgccgggg ctgggagccg cgctgggcct 1450 acagcccgct gctgcagcag tgccatccct tcgtgtacgg tggctgcgag ggcaacggca 1510 acaacttcca cagccgcgag agctgcgagg atgcctgccc cgtgccgcgc acaccgccct 1570 gccgcgcctg ccgcctccgg agcaagctgg cgctgagcct gtgccgcagc gacttcgcca 1630 tcgtggggcg gctcacggag gtgctggagg agcccgaggc cgccggcggc atcgcccgcg 1690 tggcgctcga ggacgtgctc aaggatgaca agatgggcct caagttcttg ggcaccaagt 1750 acctggaggt gacgctgagt ggcatggact gggcctgccc ctgccccaac atgacggcgg 1810 gcgacgggcc gctggtcatc atgggtgagg tgcgcgatgg cgtggccgtg ctggacgccg 1870 gcagctacgt ccgcgccgcc agcgagaagc gcgtcaagaa gatcttggag ctgctggaga 1930 agcaggcctg cgagctgctc aaccgcttcc aggactagcc cccgcagggg cctgcgccac 1990 cccgtcctgg tgaataaacg cactccctgt gcctcag 2027 <210> 34 <211> 216 <212> PRT <213> Homo sapiens <400> 34 Met Pro Ala Leu Arg Pro Leu Leu Pro Leu Leu Leu Leu Leu Arg Leu 1 5 10 15 Thr Ser Gly Ala Gly Leu Leu Pro Gly Leu Gly Ser His Pro Gly Val 20 25 30 Cys Pro Asn Gln Leu Ser Pro Asn Leu Trp Val Asp Ala Gln Ser Thr 35 40 45 Cys Glu Arg Glu Cys Ser Arg Asp Gln Asp Cys Ala Ala Ala Glu Lys 50 55 60 Cys Cys Ile Asn Val Cys Gly Leu His Ser Cys Val Ala Ala Arg Phe 65 70 75 80 Pro Gly Ser Pro Ala Ala Pro Thr Thr Ala Ala Ser Cys Glu Gly Phe 85 90 95 Val Cys Pro Gln Gln Gly Ser Asp Cys Asp Ile Trp Asp Gly Gln Pro 100 105 110 Val Cys Arg Cys Arg Asp Arg Cys Glu Lys Glu Pro Ser Phe Thr Cys 115 120 125 Ala Ser Asp Gly Leu Thr Tyr Tyr Asn Arg Cys Tyr Met Asp Ala Glu 130 135 140 Ala Cys Cys Gly Ala Cys Thr Ser Thr Ser Cys Pro Ala Ser Thr Cys 145 150 155 160 Ser Ala Gly Arg Pro Ala Ala Arg Gly Arg Arg Arg Pro Leu Pro Ala 165 170 175 Pro His Leu Gly Pro Arg Pro Cys Leu Leu Pro Cys Thr Ala Ala Pro 180 185 190 Pro His Arg Arg Cys Arg Leu Gly Val Arg Pro Ala Ser Thr Ala Thr 195 200 205 Ser Ala Ala Ala Arg Arg Leu Leu 210 215 <210> 35 <211> 2518 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (30)..(749) <400> 35 acgtcggacc cggaggccct gaatgcccc atg cgc acc cca cag ctc gcg ctc 53 Met Arg Thr Pro Gln Leu Ala Leu 1 5 ctg caa gtg ttc ttt ctg gtg ttc ccc gat ggc gtc cgg cct cag ccc 101 Leu Gln Val Phe Phe Leu Val Phe Pro Asp Gly Val Arg Pro Gln Pro 10 15 20 tct tcc tcc cca tca gag gca gtg ccc acg tct ttg gag ctg cag cga 149 Ser Ser Ser Pro Ser Glu Ala Val Pro Thr Ser Leu Glu Leu Gln Arg 25 30 35 40 ggg acg gat ggc gga acc ctc cag tcc cct tca gag gcg act gca act 197 Gly Thr Asp Gly Gly Thr Leu Gln Ser Pro Ser Glu Ala Thr Ala Thr 45 50 55 cgc ccg gcc gtg cct gga ctc cct aca gtg gtc cct act ctc gtg act 245 Arg Pro Ala Val Pro Gly Leu Pro Thr Val Val Pro Thr Leu Val Thr 60 65 70 ccc tcg gcc cct ggg aat agg act gtg gac ctc ttc cca gtc tta ccg 293 Pro Ser Ala Pro Gly Asn Arg Thr Val Asp Leu Phe Pro Val Leu Pro 75 80 85 atc tgt gtc tgt gac ttg act cct gga gcc tgc gat ata aat tgc tgc 341 Ile Cys Val Cys Asp Leu Thr Pro Gly Ala Cys Asp Ile Asn Cys Cys 90 95 100 tgc gac agg gac tgc tat ctt ctc cat ccg agg aca gtt ttc tcc ttc 389 Cys Asp Arg Asp Cys Tyr Leu Leu His Pro Arg Thr Val Phe Ser Phe 105 110 115 120 tgc ctt cca ggc agc gta agg tct tca agc tgg gtt tgt gta gac aac 437 Cys Leu Pro Gly Ser Val Arg Ser Ser Ser Trp Val Cys Val Asp Asn 125 130 135 tct gtt atc ttc agg agt aat tcc ccg ttt cct tca aga gtt ttc atg 485 Ser Val Ile Phe Arg Ser Asn Ser Pro Phe Pro Ser Arg Val Phe Met 140 145 150 gat tct aat gga atc agg cag ttt tgt gtc cat gtg aac aac tca aac 533 Asp Ser Asn Gly Ile Arg Gln Phe Cys Val His Val Asn Asn Ser Asn 155 160 165 tta aac tat ttc cag aag ctt caa aag gtc aat gca acc aac ttc cag 581 Leu Asn Tyr Phe Gln Lys Leu Gln Lys Val Asn Ala Thr Asn Phe Gln 170 175 180 gcc ctg gct gca gag ttt gga ggc gaa tca ttc act tca aca ttc caa 629 Ala Leu Ala Ala Glu Phe Gly Gly Glu Ser Phe Thr Ser Thr Phe Gln 185 190 195 200 aca caa tca cca cca tct ttt tac agg gct ggg gac ccc att ctt act 677 Thr Gln Ser Pro Pro Ser Phe Tyr Arg Ala Gly Asp Pro Ile Leu Thr 205 210 215 tac ttc ccc aag tgg tct gta ata agc ttg ctg aga caa cct gca gga 725 Tyr Phe Pro Lys Trp Ser Val Ile Ser Leu Leu Arg Gln Pro Ala Gly 220 225 230 gtt gga gct ggg ggg act ctg tgc tgaaagcaat cctgcaggtt tcctagagag 779 Val Gly Ala Gly Gly Thr Leu Cys 235 240 taaaagtaca acttgcactc gttttttcaa gaacctggct agtagctgta ccttggattc 839 agccctcaat gctgcctctt actataactt cacagtctta aaggttccaa gaagcatgac 899 tgatccacag aatatggagt tccaggttcc tgtaatactt acctcacagg ctaatgctcc 959 tctgttggct ggaaacactt gtcagaatgt agtttctcag gtcacctatg agatagagac 1019 caatgggact tttggaatcc agaaagtttc tgtcagtttg ggacaaacca acctgactgt 1079 tgagccaggc gcttccttac agcaacactt catccttcgc ttcagggctt ttcaacagag 1139 cacagctgct tctctcacca gtcctagaag tgggaatcct ggctatatag ttgggaagcc 1199 actcttggct ctgactgatg atataagtta ctcaatgacc ctcttacaga gccagggtaa 1259 tggaagttgc tctgttaaaa gacatgaagt gcagtttgga gtgaatgcaa tatctggatg 1319 caagctcagg ttgaagaagg cagactgcag ccacttgcag caggagattt atcagactct 1379 tcatggaagg cccagaccag agtatgttgc catctttggt aatgctgacc cagcccagaa 1439 aggagggtgg accaggatcc tcaacaggca ctgcagcatt tcagctataa actgtacttc 1499 ctgccgtctc ataccagttt ccctggagat ccaggtattg tgggcatatg taggtctcct 1559 gtccaacccg caagctcatg tatcaggagt tcgattccta taccagtgcc agtctataca 1619 ggattctcag caagttacag aagtatcttt gacaactctt gtgaactttg tggacattac 1679 ccagaagcca cagcctccaa ggggccaacc caaaatggac tggaaatggc cattcgactt 1739 ctttcccttc aaagtggcat tcagcagagg agtattctct caaaaatgct cagtctctcc 1799 catccttatc ctgtgcctct tactacttgg agttctcaac ctagagacta tgtgaagaaa 1859 agaaaataat cagatttcag ttttccctat gagaaactct gaggcagcca cttatcttgg 1919 ctaaatagaa cctcacctgc tcatgaccag agagcattta ggataataga ggacctaact 1979 gaaggaatcc ttgtatatga aaggagttat tttagaaaag caataaaaat attttattca 2039 tcatagctct ctgctttggg ctctgcaggc caccagatac acatgaggcc cctacttctc 2099 aagctgggaa ggccaagagc cttccttcag cctttctggt tatgttacac ctagctgaat 2159 gtttacaagg tctggatcca tcagccctca ggcacagttg ggccaagcag aaagagagaa 2219 acacttctgc tgtcaccttg aatgaactca ggaatagctt ccctctggac tgtagaggag 2279 ctaactgttt ggaacagaaa actgctggct gttgattttg tctggttcct ttgccaacat 2339 ctgggcacac cctttgccca gacacgagtg gggaaagcag ttctttctcc tcagtttcca 2399 aagtaaatgg ggaatcccag ctttcttttc tactagcaaa tgaccctacc atttatttct 2459 gcctttttct tccgttcatt gtgaggaaaa ataaaactgg ttgagagctt tgttgtact 2518 <210> 36 <211> 240 <212> PRT <213> Homo sapiens <400> 36 Met Arg Thr Pro Gln Leu Ala Leu Leu Gln Val Phe Phe Leu Val Phe 1 5 10 15 Pro Asp Gly Val Arg Pro Gln Pro Ser Ser Ser Pro Ser Glu Ala Val 20 25 30 Pro Thr Ser Leu Glu Leu Gln Arg Gly Thr Asp Gly Gly Thr Leu Gln 35 40 45 Ser Pro Ser Glu Ala Thr Ala Thr Arg Pro Ala Val Pro Gly Leu Pro 50 55 60 Thr Val Val Pro Thr Leu Val Thr Pro Ser Ala Pro Gly Asn Arg Thr 65 70 75 80 Val Asp Leu Phe Pro Val Leu Pro Ile Cys Val Cys Asp Leu Thr Pro 85 90 95 Gly Ala Cys Asp Ile Asn Cys Cys Cys Asp Arg Asp Cys Tyr Leu Leu 100 105 110 His Pro Arg Thr Val Phe Ser Phe Cys Leu Pro Gly Ser Val Arg Ser 115 120 125 Ser Ser Trp Val Cys Val Asp Asn Ser Val Ile Phe Arg Ser Asn Ser 130 135 140 Pro Phe Pro Ser Arg Val Phe Met Asp Ser Asn Gly Ile Arg Gln Phe 145 150 155 160 Cys Val His Val Asn Asn Ser Asn Leu Asn Tyr Phe Gln Lys Leu Gln 165 170 175 Lys Val Asn Ala Thr Asn Phe Gln Ala Leu Ala Ala Glu Phe Gly Gly 180 185 190 Glu Ser Phe Thr Ser Thr Phe Gln Thr Gln Ser Pro Pro Ser Phe Tyr 195 200 205 Arg Ala Gly Asp Pro Ile Leu Thr Tyr Phe Pro Lys Trp Ser Val Ile 210 215 220 Ser Leu Leu Arg Gln Pro Ala Gly Val Gly Ala Gly Gly Thr Leu Cys 225 230 235 240 <210> 37 <211> 1631 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (16)..(1131) <400> 37 gttacggccg aaaag atg gcg gtc ttg gca cct cta att gct ctc gtg tat 51 Met Ala Val Leu Ala Pro Leu Ile Ala Leu Val Tyr 1 5 10 tcg gtg ccg cga ctt tca cga tgg ctc gcc caa cct tac tac ctt ctg 99 Ser Val Pro Arg Leu Ser Arg Trp Leu Ala Gln Pro Tyr Tyr Leu Leu 15 20 25 tcg gcc ctg ctc tct gct gcc ttc cta ctc gtg agg aaa ctg ccg ccg 147 Ser Ala Leu Leu Ser Ala Ala Phe Leu Leu Val Arg Lys Leu Pro Pro 30 35 40 ctc tgc cac ggt ctg ccc acc caa cgc gaa gac ggt aac ccg tgt gac 195 Leu Cys His Gly Leu Pro Thr Gln Arg Glu Asp Gly Asn Pro Cys Asp 45 50 55 60 ttt gac tgg aga gaa gtg gag atc ctg atg ttt ctc agt gcc att gtg 243 Phe Asp Trp Arg Glu Val Glu Ile Leu Met Phe Leu Ser Ala Ile Val 65 70 75 atg atg aag aac cgc aga tcc atc act gtg gag caa cat ata ggc aac 291 Met Met Lys Asn Arg Arg Ser Ile Thr Val Glu Gln His Ile Gly Asn 80 85 90 att ttc atg ttt agt aaa gtg gcc aac aca att ctt ttc ttc cgc ttg 339 Ile Phe Met Phe Ser Lys Val Ala Asn Thr Ile Leu Phe Phe Arg Leu 95 100 105 gat att cgc atg ggc cta ctt tac atc aca ctc tgc ata gtg ttc ctg 387 Asp Ile Arg Met Gly Leu Leu Tyr Ile Thr Leu Cys Ile Val Phe Leu 110 115 120 atg acg tgc aaa ccc ccc cta tat atg ggc cct gag tat atc aag tac 435 Met Thr Cys Lys Pro Pro Leu Tyr Met Gly Pro Glu Tyr Ile Lys Tyr 125 130 135 140 ttc aat gat aaa acc att gat gag gaa cta gaa cgg gac aag agg gtc 483 Phe Asn Asp Lys Thr Ile Asp Glu Glu Leu Glu Arg Asp Lys Arg Val 145 150 155 act tgg att gtg gag ttc ttt gcc aat tgg tct aat gac tgc caa tca 531 Thr Trp Ile Val Glu Phe Phe Ala Asn Trp Ser Asn Asp Cys Gln Ser 160 165 170 ttt gcc cct atc tat gct gac ctc tcc ctt aaa tac aac tgt aca ggg 579 Phe Ala Pro Ile Tyr Ala Asp Leu Ser Leu Lys Tyr Asn Cys Thr Gly 175 180 185 cta aat ttt ggg aag gtg gat gtt gga cgc tat act gat gtt agt acg 627 Leu Asn Phe Gly Lys Val Asp Val Gly Arg Tyr Thr Asp Val Ser Thr 190 195 200 cgg tac aaa gtg agc aca tca ccc ctc acc aag caa ctc cct acc ctg 675 Arg Tyr Lys Val Ser Thr Ser Pro Leu Thr Lys Gln Leu Pro Thr Leu 205 210 215 220 atc ctg ttc caa ggt ggc aag gag gca atg cgg cgg cca cag att gac 723 Ile Leu Phe Gln Gly Gly Lys Glu Ala Met Arg Arg Pro Gln Ile Asp 225 230 235 aag aaa gga cgg gct gtc tca tgg acc ttc tct gag gag aat gtg atc 771 Lys Lys Gly Arg Ala Val Ser Trp Thr Phe Ser Glu Glu Asn Val Ile 240 245 250 cga gaa ttt aac tta aat gag cta tac cag cgg gcc aag aaa cta tca 819 Arg Glu Phe Asn Leu Asn Glu Leu Tyr Gln Arg Ala Lys Lys Leu Ser 255 260 265 aag gct gga gac aat atc cct gag gag cag cct gtg gct caa ccc cca 867 Lys Ala Gly Asp Asn Ile Pro Glu Glu Gln Pro Val Ala Gln Pro Pro 270 275 280 cca cag tgt cag atg ggg aaa aca aga agg ata aat aag atc ctc act 915 Pro Gln Cys Gln Met Gly Lys Thr Arg Arg Ile Asn Lys Ile Leu Thr 285 290 295 300 ttg gca gtg ctg cct ctc ctg tca att cca ggc tct ttc cat aac cac 963 Leu Ala Val Leu Pro Leu Leu Ser Ile Pro Gly Ser Phe His Asn His 305 310 315 aag cct gag gct gca gcc ttt tat tta tgt ttt ccc ttt ggc tgt gac 1011 Lys Pro Glu Ala Ala Ala Phe Tyr Leu Cys Phe Pro Phe Gly Cys Asp 320 325 330 tgg gtg ggg cag cat gca gct tct gat ttt aaa gag gca tct agg gaa 1059 Trp Val Gly Gln His Ala Ala Ser Asp Phe Lys Glu Ala Ser Arg Glu 335 340 345 ttg tca ggc acc cta cag gaa ggc ctg cca tgc tgt ggc caa ctg ttt 1107 Leu Ser Gly Thr Leu Gln Glu Gly Leu Pro Cys Cys Gly Gln Leu Phe 350 355 360 cac tgg agc aag aaa gag atc tca taggacggag ggggaaatgg tttccctcca 1161 His Trp Ser Lys Lys Glu Ile Ser 365 370 agcttgggtc agtgtgttaa ctgcttatca gctattcaga catctccatg gtttctccat 1221 gaaactctgt ggtttcatca ttccttctta gttgacctgc acagcttggt tagacctaga 1281 tttaacccta aggtaagatg ctggggtata gaacgctaag aattttcccc caaggactct 1341 tgcttcctta agcccttctg gcttcgttta tggtcttcat taaaagtata agcctaactt 1401 tgtcgctagt cctaaggaga aacctttaac cacaaagttt ttatcattga agacaatatt 1461 gaacaacccc ctattttgtg gggattgaga aggggtgaat agaggcttga gactttcctt 1521 tgtgtggtag gacttggagg agaaatcccc tggactttca ctaactctct gacatactcc 1581 ccacacccag ttgatggcct tccgtaataa aaagattggg atttcctttt 1631 <210> 38 <211> 372 <212> PRT <213> Homo sapiens <400> 38 Met Ala Val Leu Ala Pro Leu Ile Ala Leu Val Tyr Ser Val Pro Arg 1 5 10 15 Leu Ser Arg Trp Leu Ala Gln Pro Tyr Tyr Leu Leu Ser Ala Leu Leu 20 25 30 Ser Ala Ala Phe Leu Leu Val Arg Lys Leu Pro Pro Leu Cys His Gly 35 40 45 Leu Pro Thr Gln Arg Glu Asp Gly Asn Pro Cys Asp Phe Asp Trp Arg 50 55 60 Glu Val Glu Ile Leu Met Phe Leu Ser Ala Ile Val Met Met Lys Asn 65 70 75 80 Arg Arg Ser Ile Thr Val Glu Gln His Ile Gly Asn Ile Phe Met Phe 85 90 95 Ser Lys Val Ala Asn Thr Ile Leu Phe Phe Arg Leu Asp Ile Arg Met 100 105 110 Gly Leu Leu Tyr Ile Thr Leu Cys Ile Val Phe Leu Met Thr Cys Lys 115 120 125 Pro Pro Leu Tyr Met Gly Pro Glu Tyr Ile Lys Tyr Phe Asn Asp Lys 130 135 140 Thr Ile Asp Glu Glu Leu Glu Arg Asp Lys Arg Val Thr Trp Ile Val 145 150 155 160 Glu Phe Phe Ala Asn Trp Ser Asn Asp Cys Gln Ser Phe Ala Pro Ile 165 170 175 Tyr Ala Asp Leu Ser Leu Lys Tyr Asn Cys Thr Gly Leu Asn Phe Gly 180 185 190 Lys Val Asp Val Gly Arg Tyr Thr Asp Val Ser Thr Arg Tyr Lys Val 195 200 205 Ser Thr Ser Pro Leu Thr Lys Gln Leu Pro Thr Leu Ile Leu Phe Gln 210 215 220 Gly Gly Lys Glu Ala Met Arg Arg Pro Gln Ile Asp Lys Lys Gly Arg 225 230 235 240 Ala Val Ser Trp Thr Phe Ser Glu Glu Asn Val Ile Arg Glu Phe Asn 245 250 255 Leu Asn Glu Leu Tyr Gln Arg Ala Lys Lys Leu Ser Lys Ala Gly Asp 260 265 270 Asn Ile Pro Glu Glu Gln Pro Val Ala Gln Pro Pro Pro Gln Cys Gln 275 280 285 Met Gly Lys Thr Arg Arg Ile Asn Lys Ile Leu Thr Leu Ala Val Leu 290 295 300 Pro Leu Leu Ser Ile Pro Gly Ser Phe His Asn His Lys Pro Glu Ala 305 310 315 320 Ala Ala Phe Tyr Leu Cys Phe Pro Phe Gly Cys Asp Trp Val Gly Gln 325 330 335 His Ala Ala Ser Asp Phe Lys Glu Ala Ser Arg Glu Leu Ser Gly Thr 340 345 350 Leu Gln Glu Gly Leu Pro Cys Cys Gly Gln Leu Phe His Trp Ser Lys 355 360 365 Lys Glu Ile Ser 370 <210> 39 <211> 3707 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (122)..(1270) <400> 39 actcggctgt gcggcggggc aggcatggga gccgcgcgct ctctcccggc gcccacacct 60 gtctgagcgg cgcagcgagc cgcggcccgg gcgggctgct cggcgcggaa cagtgctcgg 120 c atg gca ggg att cca ggg ctc ctc ttc ctt ctc ttc ttt ctg ctc tgt 169 Met Ala Gly Ile Pro Gly Leu Leu Phe Leu Leu Phe Phe Leu Leu Cys 1 5 10 15 gct gtt ggg caa gtg agc cct tac agt gcc ccc tgg aaa ccc act tgg 217 Ala Val Gly Gln Val Ser Pro Tyr Ser Ala Pro Trp Lys Pro Thr Trp 20 25 30 cct gca tac cgc ctc cct gtc gtc ttg ccc cag tct acc ctc aat tta 265 Pro Ala Tyr Arg Leu Pro Val Val Leu Pro Gln Ser Thr Leu Asn Leu 35 40 45 gcc aag cca gac ttt gga gcc gaa gcc aaa tta gaa gta tct tct tca 313 Ala Lys Pro Asp Phe Gly Ala Glu Ala Lys Leu Glu Val Ser Ser Ser 50 55 60 tgt gga ccc cag tgt cat aag gga act cca ctg ccc act tac gaa gag 361 Cys Gly Pro Gln Cys His Lys Gly Thr Pro Leu Pro Thr Tyr Glu Glu 65 70 75 80 gcc aag caa tat ctg tct tat gaa acg ctc tat gcc aat ggc agc cgc 409 Ala Lys Gln Tyr Leu Ser Tyr Glu Thr Leu Tyr Ala Asn Gly Ser Arg 85 90 95 aca gag acg cag gtg ggc atc tac atc ctc agc agt agt gga gat ggg 457 Thr Glu Thr Gln Val Gly Ile Tyr Ile Leu Ser Ser Ser Gly Asp Gly 100 105 110 gcc caa cac cga gac tca ggg tct tca gga aag tct cga agg aag cgg 505 Ala Gln His Arg Asp Ser Gly Ser Ser Gly Lys Ser Arg Arg Lys Arg 115 120 125 cag att tat ggc tat gac agc agg ttc agc att ttt ggg aag gac ttc 553 Gln Ile Tyr Gly Tyr Asp Ser Arg Phe Ser Ile Phe Gly Lys Asp Phe 130 135 140 ctg ctc aac tac cct ttc tca aca tca gtg aag tta tcc acg ggc tgc 601 Leu Leu Asn Tyr Pro Phe Ser Thr Ser Val Lys Leu Ser Thr Gly Cys 145 150 155 160 acc ggc acc ctg gtg gca gag aag cat gtc ctc aca gct gcc cac tgc 649 Thr Gly Thr Leu Val Ala Glu Lys His Val Leu Thr Ala Ala His Cys 165 170 175 ata cac gat gga aaa acc tat gtg aaa gga acc cag aag ctt cga gtg 697 Ile His Asp Gly Lys Thr Tyr Val Lys Gly Thr Gln Lys Leu Arg Val 180 185 190 ggc ttc cta aag ccc aag ttt aaa gat ggt ggt cga ggg gcc aac gac 745 Gly Phe Leu Lys Pro Lys Phe Lys Asp Gly Gly Arg Gly Ala Asn Asp 195 200 205 tcc act tca gcc atg ccc gag cag atg aaa ttt cag tgg atc cgg gtg 793 Ser Thr Ser Ala Met Pro Glu Gln Met Lys Phe Gln Trp Ile Arg Val 210 215 220 aaa cgc acc cat gtg ccc aag ggt tgg atc aag ggc aat gcc aat gac 841 Lys Arg Thr His Val Pro Lys Gly Trp Ile Lys Gly Asn Ala Asn Asp 225 230 235 240 atc ggc atg gat tat gat tat gcc ctc ctg gaa ctc aaa aag ccc cac 889 Ile Gly Met Asp Tyr Asp Tyr Ala Leu Leu Glu Leu Lys Lys Pro His 245 250 255 aag aga aaa ttt atg aag att ggg gtg agc cct cct gct aag cag ctg 937 Lys Arg Lys Phe Met Lys Ile Gly Val Ser Pro Pro Ala Lys Gln Leu 260 265 270 cca ggg gac aga att cac ttc tct ggt tat gac aat gac cga cca ggc 985 Pro Gly Asp Arg Ile His Phe Ser Gly Tyr Asp Asn Asp Arg Pro Gly 275 280 285 aat ttg gtg tat cgc ttc tgt gac gtc aaa gac gag acc tat gac ttg 1033 Asn Leu Val Tyr Arg Phe Cys Asp Val Lys Asp Glu Thr Tyr Asp Leu 290 295 300 ctc tac cag caa tgc gat gcc cag cca ggg gcc agc ggg tct ggg gtc 1081 Leu Tyr Gln Gln Cys Asp Ala Gln Pro Gly Ala Ser Gly Ser Gly Val 305 310 315 320 tat gtg agg atg tgg aag aga cag cag cag aag tgg gag cga aaa att 1129 Tyr Val Arg Met Trp Lys Arg Gln Gln Gln Lys Trp Glu Arg Lys Ile 325 330 335 att ggc att ttt tca ggg cac cag tgg gtg gac atg aat ggt tcc cca 1177 Ile Gly Ile Phe Ser Gly His Gln Trp Val Asp Met Asn Gly Ser Pro 340 345 350 cag gat ttc aac gtg gct gtc aga atc act cct ctc aaa tat gcc cag 1225 Gln Asp Phe Asn Val Ala Val Arg Ile Thr Pro Leu Lys Tyr Ala Gln 355 360 365 att tgc tat tgg att aaa gga aac tac ctg gat tgt agg gag ggg 1270 Ile Cys Tyr Trp Ile Lys Gly Asn Tyr Leu Asp Cys Arg Glu Gly 370 375 380 tgacacagtg ttccctcctg gcagcaatta agggtcttca tgttcttatt ttaggagagg 1330 ccaaattgtt ttttgtcatt ggcgtgcaca cgtgtgtgtg tgtgtgtgtg tgtgtgtaag 1390 gtgtcttata atcttttacc tatttcttac aattgcaaga tgactggctt tactatttga 1450 aaactggttt gtgtatcata tcatatatca tttaagcagt ttgaaggcat acttttgcat 1510 agaaataaaa aaaatactga tttggggcaa tgaggaatat ttgacaatta agttaatctt 1570 cacgtttttg caaactttga tttttatttc atctgaactt gtttcaaaga tttatattaa 1630 atatttggca tacaagagat atgaattctt atatgtgtgc atgtgtgttt tcttctgaga 1690 ttcatcttgg tggtgggttt ttttgttttt ttaattcagt gcctgatctt taatgcttcc 1750 ataaggcagt gttcccattt aggaactttg acagcatttg ttaggcagaa tattttggat 1810 ttggaggcat ttgcatggta gtctttgaac agtaaaatga tgtgttgact atactgatac 1870 acatattaaa ctatacctta tagtaaacca gtatcccaag ctgcttttag ttccaaaaat 1930 agtttctttt ccaaaggttg ttgctctact ttgtaggaag tctttgcata tggccctccc 1990 aactttaaag tcataccaga gtggccaaga gtgtttatcc caacccttcc atttaacagg 2050 atttcactca catttctgga actagctatt tttcagaaga caataatcag ggcttaatta 2110 gaacaggctg tatttcctcc cagcaaacag ttgtggccac actaaaaaca atcatagcat 2170 tttacccctg gattatagca catctcatgt tttatcattt ggatggagta atttaaaatg 2230 aattaaattc cagagaacaa tggaagcatt gcctggcaga tgtcacaaca gaataaccac 2290 ttgtttggag cctggcacag tcctccagcc tgatcaaaaa ttattctgca tagttttcag 2350 tgtgctttct gggagctatg tacttcttca atttggaaac ttttctctct catttatagt 2410 gaaaatactt ggaagttact ttaagaaaac cagtgtggcc tttttccctc tagctttaaa 2470 agggccgctt ttgctggaat gctctaggtt atagataaac aattaggtat aatagcaaaa 2530 atgaaaattg gaagaatgca aaatggatca gaatcatgcc ttccaataaa ggcctttaca 2590 catgttttat caatatgatt atcaaatcac agcatataca gaaaagactt ggacttattg 2650 tatgttttta ttttatggct ctcggcctaa gcacttcttt ctaaatgtat cggagaaaag 2710 atcaaatgga ctacaagcac gtgtttgctg tgcttgcacc ccaggtaaac ctgcattgta 2770 gcaatttgta aggatattca gatggagcac tgtcacttag acattctctg ggggattttc 2830 tgcttgtctt tcttgagctt tttggaagga taattctgat aaggcactca agaaacgtac 2890 aaccacagtg ctttcttcaa atcatatgag aaatactatg catagcaagg agatgcagag 2950 ccgccaggaa aattctgagt tccagcacaa ttttctttgg aatctaacag gaatctagcc 3010 tgaggaagaa gggaggtctc catttctatg tctggtattt gggggttttg tttgtttttg 3070 ctttagcttg gtgaaaaaaa gttcactgaa caccaagacc agaatggatt tttttaaaaa 3130 aatagatgtt ccttttgtga agcaccttga ttccttgatt ttgatttttt gcaaagttag 3190 acaatggcac aaagtcaaaa tgaaatcaat gtttagttca caagtagatg taatttacta 3250 aagaatgata cacccatatg ctatatacag cttaactcac agaactgtaa aagaaaatta 3310 taaaataatt caacatgtcc atctttttag tgataataaa agaaagcatg gtattaaact 3370 atcatagaag tagacagaaa aagaaaaaag gactcatggc attattaata taattagtgc 3430 tttacatgtg ttagttatac atattagaag catatttgcc tagtaaggct agtagaacca 3490 catttcccaa agtgtgctcc ttaaacactc atgccttatg attttctacc aaaagtaaaa 3550 agggttgtat taagtcagag gaagatgcct ctccattttc cctctcttta tcagaggttc 3610 acatgcctgt ctgcacatta aaagctctgg gaagacctgt tgtaaaggga caagttgagg 3670 ttgtaaaatc tgcatttaaa taaacatctt tgatcac 3707 <210> 40 <211> 383 <212> PRT <213> Homo sapiens <400> 40 Met Ala Gly Ile Pro Gly Leu Leu Phe Leu Leu Phe Phe Leu Leu Cys 1 5 10 15 Ala Val Gly Gln Val Ser Pro Tyr Ser Ala Pro Trp Lys Pro Thr Trp 20 25 30 Pro Ala Tyr Arg Leu Pro Val Val Leu Pro Gln Ser Thr Leu Asn Leu 35 40 45 Ala Lys Pro Asp Phe Gly Ala Glu Ala Lys Leu Glu Val Ser Ser Ser 50 55 60 Cys Gly Pro Gln Cys His Lys Gly Thr Pro Leu Pro Thr Tyr Glu Glu 65 70 75 80 Ala Lys Gln Tyr Leu Ser Tyr Glu Thr Leu Tyr Ala Asn Gly Ser Arg 85 90 95 Thr Glu Thr Gln Val Gly Ile Tyr Ile Leu Ser Ser Ser Gly Asp Gly 100 105 110 Ala Gln His Arg Asp Ser Gly Ser Ser Gly Lys Ser Arg Arg Lys Arg 115 120 125 Gln Ile Tyr Gly Tyr Asp Ser Arg Phe Ser Ile Phe Gly Lys Asp Phe 130 135 140 Leu Leu Asn Tyr Pro Phe Ser Thr Ser Val Lys Leu Ser Thr Gly Cys 145 150 155 160 Thr Gly Thr Leu Val Ala Glu Lys His Val Leu Thr Ala Ala His Cys 165 170 175 Ile His Asp Gly Lys Thr Tyr Val Lys Gly Thr Gln Lys Leu Arg Val 180 185 190 Gly Phe Leu Lys Pro Lys Phe Lys Asp Gly Gly Arg Gly Ala Asn Asp 195 200 205 Ser Thr Ser Ala Met Pro Glu Gln Met Lys Phe Gln Trp Ile Arg Val 210 215 220 Lys Arg Thr His Val Pro Lys Gly Trp Ile Lys Gly Asn Ala Asn Asp 225 230 235 240 Ile Gly Met Asp Tyr Asp Tyr Ala Leu Leu Glu Leu Lys Lys Pro His 245 250 255 Lys Arg Lys Phe Met Lys Ile Gly Val Ser Pro Pro Ala Lys Gln Leu 260 265 270 Pro Gly Asp Arg Ile His Phe Ser Gly Tyr Asp Asn Asp Arg Pro Gly 275 280 285 Asn Leu Val Tyr Arg Phe Cys Asp Val Lys Asp Glu Thr Tyr Asp Leu 290 295 300 Leu Tyr Gln Gln Cys Asp Ala Gln Pro Gly Ala Ser Gly Ser Gly Val 305 310 315 320 Tyr Val Arg Met Trp Lys Arg Gln Gln Gln Lys Trp Glu Arg Lys Ile 325 330 335 Ile Gly Ile Phe Ser Gly His Gln Trp Val Asp Met Asn Gly Ser Pro 340 345 350 Gln Asp Phe Asn Val Ala Val Arg Ile Thr Pro Leu Lys Tyr Ala Gln 355 360 365 Ile Cys Tyr Trp Ile Lys Gly Asn Tyr Leu Asp Cys Arg Glu Gly 370 375 380 <210> 41 <211> 2652 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (52)..(444) <400> 41 gctgctgccg ccgccgcctc gggtcgtgga gccaggagcg acgtcaccgc c atg gca 57 Met Ala 1 ggc atc aaa gct ttg att agt ttg tcc ttt gga gga gca atc gga ctg 105 Gly Ile Lys Ala Leu Ile Ser Leu Ser Phe Gly Gly Ala Ile Gly Leu 5 10 15 atg ttt ttg atg ctt gga tgt gcc ctt cca ata tac aac aaa tac tgg 153 Met Phe Leu Met Leu Gly Cys Ala Leu Pro Ile Tyr Asn Lys Tyr Trp 20 25 30 ccc ctc ttt gtt cta ttt ttt tac atc ctt tca cct att cca tac tgc 201 Pro Leu Phe Val Leu Phe Phe Tyr Ile Leu Ser Pro Ile Pro Tyr Cys 35 40 45 50 ata gca aga aga tta gtg gat gat aca gat gct atg agt aac gct tgt 249 Ile Ala Arg Arg Leu Val Asp Asp Thr Asp Ala Met Ser Asn Ala Cys 55 60 65 aag gaa ctt gcc atc ttt ctt aca acg ggc att gtc gtg tca gct ttt 297 Lys Glu Leu Ala Ile Phe Leu Thr Thr Gly Ile Val Val Ser Ala Phe 70 75 80 gga ctc cct att gta ttt gcc aga gca cat ctg att gag tgg gga gct 345 Gly Leu Pro Ile Val Phe Ala Arg Ala His Leu Ile Glu Trp Gly Ala 85 90 95 tgt gca ctt gtt ctc aca gga aac aca gtc atc ttt gca act ata cta 393 Cys Ala Leu Val Leu Thr Gly Asn Thr Val Ile Phe Ala Thr Ile Leu 100 105 110 ggc ttt ttc ttg gtc ttt gga agc aat gac gac ttc agc tgg cag cag 441 Gly Phe Phe Leu Val Phe Gly Ser Asn Asp Asp Phe Ser Trp Gln Gln 115 120 125 130 tgg tgaaaagaaa ttactgaact attgtcaaat ggacttcctg tcatttgttg 494 Trp gccattcacg cacacaggag atggggcagt taatgctgaa tggtatagca agcctcttgg 554 gggtatttta ggtgctccct tctcactttt attgtaagca tactattttc acagagactt 614 gctgaaggat taaaaggatt ttctcttttg gaaaagcttg actgatttca cacttatcta 674 tagtatgctt tttgtggtgt cctgctgaat ttaaatattt atgtgttttt cctgttaggt 734 tgattttttt tggaatcaat atgcaatgtt aaacactttt ttaatgtaat catttgcatt 794 ggttaggaat tcagaattcc gccggctcta ttactggtca agtacatctt ttctcttaaa 854 attatttagc ctccattatt acaaaaaatt ataaaaataa gttttcagtc agtcaggatg 914 acatcactcc caatgttatg cagacataca gacggttggc atacgttata gactgtatac 974 tcagtgcaaa tatagctgca tttatacctc agaggggcca agtgttaatg cccatgccct 1034 ccgttaaggg ttgttggttt tactggtaga cagatgtttt gtggattgaa aattatttta 1094 tggaattgct acagaggagt gcttttcttc tcaattgtta gaagaattta tgttaaactt 1154 taaggtaagg gtgtaaaaac atttttgaga taaggttttt atttatgttt attattgtta 1214 gagtgagttg caatgtggga agaaatgaca ttgaaattcc agtttttgaa tcctgtttct 1274 atttataagt gaaatttgtg atctcctatc aacctttcat gttttaccct gttaaaatgg 1334 acatacatgg aaccactact gatgagggac agttgtatgt ttgcatcata tatgccagaa 1394 aaccttcctc tgcttcctcc ttttgactta tttggtatgt tgtatatatt acataaaata 1454 acttttcaaa tatagtttaa taacacttag aagtgtttac ttacctggaa aataattgct 1514 atgccgtaca ttcagagtgc cccctcccct gcaaggcctt gccatgatta acaagtaact 1574 tgttagtctt acagataatt catgcattaa cagtttaaga tttagaccat ggtaatagta 1634 gttcttattc tctaaggtta tatcatatgt aatttaaaat gatttttaag acaagtttcc 1694 tgtatacctc tgaactgttt tgattttgag ttcatcatga tagatctgct gtttccttat 1754 aaaaggcatt tgttgtgtga gttaatgcaa agtagccaag tccagctata tagcagcttc 1814 agaaacatac ctgaccaaaa aattcccagt aaccaggcat gatcaattta tagtggtcgt 1874 ttacatctaa taattatcag gacttttttt caggagtggg ttataaaaac attcaagttg 1934 gtctgacagt attttgttaa ggatatttgt ttgtatgttt attcagtata cttacataaa 1994 aattatttcg ccatcagcca aaactcagta atcatgacag ctgtctgttg ttttatgaag 2054 tttatttctc aagaaaatgg gaataaattt gggatttgtt cagctttttt actaaagatg 2114 cctaaagcca caggttttat tgcctaactt aagccatgac ttttagatat gagatgacgg 2174 gaagcaggac gaaatatcgg cgtgtggctg gagccttccc actggaggct gaaagtggct 2234 tgtggtatta taatgttcag atttcaagag gaaggtgcag gtacacatga gttagagagc 2294 tggtgagaca gttgggaact ctttgtgctt gtgatctact ggactttttt tttgcaggaa 2354 gtgcattctc tggtccttcc ctattttctg ttctggatgt cagtgcagtg cactgctact 2414 gttttatcca cttggccaca gactttttct aacagctgcg tattatttct atatactaat 2474 tgcattggca gcattgtgtc tttgaccttg tatactagct tgacatagtg ctgtctctga 2534 tttctaggct agttacttga gatatgaatt ttccatagaa tatgcactga tacaacatta 2594 ccattcttct atggaaagaa aacttttgat gatgaaacaa taaagatttt aaatatct 2652 <210> 42 <211> 131 <212> PRT <213> Homo sapiens <400> 42 Met Ala Gly Ile Lys Ala Leu Ile Ser Leu Ser Phe Gly Gly Ala Ile 1 5 10 15 Gly Leu Met Phe Leu Met Leu Gly Cys Ala Leu Pro Ile Tyr Asn Lys 20 25 30 Tyr Trp Pro Leu Phe Val Leu Phe Phe Tyr Ile Leu Ser Pro Ile Pro 35 40 45 Tyr Cys Ile Ala Arg Arg Leu Val Asp Asp Thr Asp Ala Met Ser Asn 50 55 60 Ala Cys Lys Glu Leu Ala Ile Phe Leu Thr Thr Gly Ile Val Val Ser 65 70 75 80 Ala Phe Gly Leu Pro Ile Val Phe Ala Arg Ala His Leu Ile Glu Trp 85 90 95 Gly Ala Cys Ala Leu Val Leu Thr Gly Asn Thr Val Ile Phe Ala Thr 100 105 110 Ile Leu Gly Phe Phe Leu Val Phe Gly Ser Asn Asp Asp Phe Ser Trp 115 120 125 Gln Gln Trp 130 <210> 43 <211> 3293 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (106)..(786) <400> 43 tttactcttg cattcttccc agcaacaata tggctttttc ttcagctttt atcaatcaca 60 cccatcaacg aatggctttt aaaaggtttg cagacagtag gttgc atg cct ccg cct 117 Met Pro Pro Pro 1 gtg tct tct gca gtg att tta acc aag gca gtt ggt gga aat gag gca 165 Val Ser Ser Ala Val Ile Leu Thr Lys Ala Val Gly Gly Asn Glu Ala 5 10 15 20 gct gca ata ttt aat tca gcc ttt gga agt ttt ttg ggc atc gtt ata 213 Ala Ala Ile Phe Asn Ser Ala Phe Gly Ser Phe Leu Gly Ile Val Ile 25 30 35 aca ccc ctg ctc ctg ctg ctt ttt ctt ggt tca tct tct tct gtg cct 261 Thr Pro Leu Leu Leu Leu Leu Phe Leu Gly Ser Ser Ser Ser Val Pro 40 45 50 ttc aca tct att ttt tct cag ctt ttt atg act gtt gtg gtt cct ctc 309 Phe Thr Ser Ile Phe Ser Gln Leu Phe Met Thr Val Val Val Pro Leu 55 60 65 atc att gga cag att gtc cga aga tac atc aag gat tgg ctt gag aga 357 Ile Ile Gly Gln Ile Val Arg Arg Tyr Ile Lys Asp Trp Leu Glu Arg 70 75 80 aag aag cct cct ttt ggt gct atc agc agc agt gta ctc ctc atg atc 405 Lys Lys Pro Pro Phe Gly Ala Ile Ser Ser Ser Val Leu Leu Met Ile 85 90 95 100 atc tac aca aca ttc tgt gac acg ttc tct aac cca aat att gac ctg 453 Ile Tyr Thr Thr Phe Cys Asp Thr Phe Ser Asn Pro Asn Ile Asp Leu 105 110 115 gat aaa ttc agc ctt gtt ctc ata ctg ttc ata ata ttt tct atc cag 501 Asp Lys Phe Ser Leu Val Leu Ile Leu Phe Ile Ile Phe Ser Ile Gln 120 125 130 ctg agt ttt atg ctt tta act ttc atc ttt tca aca agg aat aat tcg 549 Leu Ser Phe Met Leu Leu Thr Phe Ile Phe Ser Thr Arg Asn Asn Ser 135 140 145 ggt ttc aca cca gca gac aca gtg gct atc att ttc tgt tct aca cac 597 Gly Phe Thr Pro Ala Asp Thr Val Ala Ile Ile Phe Cys Ser Thr His 150 155 160 aaa tcc ctt aca ttg gga att ccg atg ctg aag atc gtg ttt gca ggc 645 Lys Ser Leu Thr Leu Gly Ile Pro Met Leu Lys Ile Val Phe Ala Gly 165 170 175 180 cat gag tat ctc tct tta ata tct gta ccc ttg ctc atc tac cac cca 693 His Glu Tyr Leu Ser Leu Ile Ser Val Pro Leu Leu Ile Tyr His Pro 185 190 195 gct cag atc ctt ctg gga agt gtg ttg gtg cca aca atc aag tct tgg 741 Ala Gln Ile Leu Leu Gly Ser Val Leu Val Pro Thr Ile Lys Ser Trp 200 205 210 atg gta tca agg cag aag gga gtg aag ctg aca agg ccg aca gta 786 Met Val Ser Arg Gln Lys Gly Val Lys Leu Thr Arg Pro Thr Val 215 220 225 taacaaagga ggtggacttt ctgtagcaat gtatatatgt acaggattgt acatactagc 846 aattctgaag acttgtactt gtgaatgttg cctcaatgca tattttattt ttttacacaa 906 aaatatgaga tcctgtttaa gtgccttaaa atgtatttga caagagcgtt atttccaaaa 966 tatgctttgt tgattactgc caggggtggt acaatatttg ggggttaatt ttgctttcct 1026 aatgcaggaa tcagtcatgg taagtgacaa aaagcaaaca tgctttccct gcagcacctt 1086 tgtataatac aaccctatag tagttactgt aatgtttgaa atgaggtcac accatcagga 1146 aaatgccctt ctgatgacag tgaaaatttc caaagtctta ttcatgcata ctttgattta 1206 ctgtgtgatt ctttttttct acgactgtga catgcctctt ccttatcaac tcagcagggg 1266 tcatagatcg aatagatgct gaaaagcgta agatatatgc attccttgac atcattttta 1326 aagacattcc ttcaaatagt ttccacacag aaattcctca ctcccattat gagagattgt 1386 ggttatatgt cttaaattta ttataagctg cttcaaagaa agggtctgaa tgtttgaatt 1446 atgagtgaaa tcatgtgaaa ttttgagtta aactctgtga tttgattttc agggtcttta 1506 aaatatatct taatatcttc ttcctcttta ttcaataatt tctgtcttgc acttacacac 1566 tcataacagc caaatatgag gcacaaaaat gttacaatca gtttgaaagc agcatcaatt 1626 aatggtagat tctattcaca ttccacaacc cagaccaaat ttttttcctt acgcagatgt 1686 gctgagcact ttccagattg cccctgttgg ccaaaagcag cctgttacat cctggaatta 1746 agcacactta aggtatttga gacaatttat taatgaaagt ttccttggca gatttgacaa 1806 atgttggcaa tattttttta aaagttaaat catattgctt tcatgaataa atgaaaatat 1866 aaaggtcatg gatgcaaaca aatgttacat atacacattc tgtctctcca gatgaaaaga 1926 acatgcaaaa ccatttaata accaaaatat caagtaaaat tagttcccaa cggggcagca 1986 gctttcaaat gagtgtccaa tatttgcttc tgctatagct gcaagaactg taactggacc 2046 caagtagaga atgaagccac gtatagaact acgagaacac ttttctgtgt ttcccccatg 2106 ccgtcctgtc acatcctctt acacgtcctc tcttgatttg atagacaata ttggcatcct 2166 gggtctcact gaggccgtgc tatgtcctca gcagctgttt ttgttgtttc gttattatgc 2226 ccacaacaaa aaatcattcc ttagaaactc accaagttta tctactgtgt aaatttatat 2286 tattgttact accaggtctc atcttttgtc aatgtcattg aataaacttc ataagagtta 2346 ttctcagtgt gaattttaag gctaatgcca gatcctgcaa aaatctatgc taaccaggct 2406 gtagtacaca ctgttataaa gaattttact tgtgtctaaa actacagtaa ttttgcttag 2466 gtaattgtgc ttacctatgg agcacaggaa ggctcttagg ttttgttcct acaagtttct 2526 ttgaattttg gagtaaatgg aagtgtctgt ctgtctgtca tctatctgcc ctatcataaa 2586 aatctttctc cctaacatta aaatactgat ccccgccccc aacttatcta cctctattgt 2646 ctaacaccta tagtaggtgt gatcatggga taaaattcaa ctgaaaatgc tatgataaca 2706 ttttatcgtt tgctttaaaa atgtgctttg ttttcaaata atctttacat agtgaacttt 2766 ggtggcgtta gtgatatgtt tatgcctatt tctttttttt acacaaattc cttggcatat 2826 tttttcataa agaacaaaaa ataaaatcaa aatttatttt taattcatgc ttattgggat 2886 ttaattattc agagcttaaa atattttgtt atgtttatac actgtaaagc tatctgtttt 2946 atgcatttgt tttgtctaaa tgtatttatg aaagaaatac attagattat atttatgttt 3006 actcattttt ccacctggat tttttttaat ggttgttaca aaattagatt ttttaatggg 3066 taataatgtt ggtattttca tgttttttct tagtattaaa atttttgtgg gttttttaaa 3126 atttttccct attctgttaa aaattaacac acctctagct aatgttcagt gtttgtgcta 3186 aataccaaat tttttcaaaa ggattggtta agtcataaag tggattattt atgatgactg 3246 gaagatgaaa ataattatat gattaaacaa agaatgtttc agaaatc 3293 <210> 44 <211> 227 <212> PRT <213> Homo sapiens <400> 44 Met Pro Pro Pro Val Ser Ser Ala Val Ile Leu Thr Lys Ala Val Gly 1 5 10 15 Gly Asn Glu Ala Ala Ala Ile Phe Asn Ser Ala Phe Gly Ser Phe Leu 20 25 30 Gly Ile Val Ile Thr Pro Leu Leu Leu Leu Leu Phe Leu Gly Ser Ser 35 40 45 Ser Ser Val Pro Phe Thr Ser Ile Phe Ser Gln Leu Phe Met Thr Val 50 55 60 Val Val Pro Leu Ile Ile Gly Gln Ile Val Arg Arg Tyr Ile Lys Asp 65 70 75 80 Trp Leu Glu Arg Lys Lys Pro Pro Phe Gly Ala Ile Ser Ser Ser Val 85 90 95 Leu Leu Met Ile Ile Tyr Thr Thr Phe Cys Asp Thr Phe Ser Asn Pro 100 105 110 Asn Ile Asp Leu Asp Lys Phe Ser Leu Val Leu Ile Leu Phe Ile Ile 115 120 125 Phe Ser Ile Gln Leu Ser Phe Met Leu Leu Thr Phe Ile Phe Ser Thr 130 135 140 Arg Asn Asn Ser Gly Phe Thr Pro Ala Asp Thr Val Ala Ile Ile Phe 145 150 155 160 Cys Ser Thr His Lys Ser Leu Thr Leu Gly Ile Pro Met Leu Lys Ile 165 170 175 Val Phe Ala Gly His Glu Tyr Leu Ser Leu Ile Ser Val Pro Leu Leu 180 185 190 Ile Tyr His Pro Ala Gln Ile Leu Leu Gly Ser Val Leu Val Pro Thr 195 200 205 Ile Lys Ser Trp Met Val Ser Arg Gln Lys Gly Val Lys Leu Thr Arg 210 215 220 Pro Thr Val 225 <210> 45 <211> 3635 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (292)..(2025) <400> 45 ttgcgacgtc gaggcgctca tggttgcagg cgggcgccgc cgttcagttc agggtctgag 60 cctggaggag tgagccaggc agtgagactg gctcgggcgg gccgggacgc gtcgttgcag 120 cagcggctcc cagctcccag ccaggattcc gcgcgcccct tcacgcgccc tgctcctgaa 180 cttcagctcc tgcacagtcc tccccaccgc aaggctcaag gcgccgccgg cgtggaccgc 240 gcacggcctc taggtctcct cgccaggaca gcaacctctc ccctggccct c atg ggc 297 Met Gly 1 acc gtc agc tcc agg cgg tcc tgg tgg ccg ctg cca ctg ctg ctg ctg 345 Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu Leu Leu 5 10 15 ctg ctg ctg ctc ctg ggt ccc gcg ggc gcc cgt gcg cag gag gac gag 393 Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu Asp Glu 20 25 30 gac ggc gac tac gag gag ctg gtg cta gcc ttg cgt tcc gag gag gac 441 Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu Glu Asp 35 40 45 50 ggc ctg gcc gaa gca ccc gag cac gga acc aca gcc acc ttc cac cgc 489 Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe His Arg 55 60 65 tgc gcc aag gat ccg tgg agg ttg cct ggc acc tac gtg gtg gtg ctg 537 Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val Val Leu 70 75 80 aag gag gag acc cac ctc tcg cag tca gag cgc act gcc cgc cgc ctg 585 Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg Arg Leu 85 90 95 cag gcc cag gct gcc cgc cgg gga tac ctc acc aag atc ctg cat gtc 633 Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu His Val 100 105 110 ttc cat ggc ctt ctt cct ggc ttc ctg gtg aag atg agt ggc gac ctg 681 Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly Asp Leu 115 120 125 130 ctg gag ctg gcc ttg aag ttg ccc cat gtc gac tac atc gag gag gac 729 Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu Glu Asp 135 140 145 tcc tct gtc ttt gcc cag agc atc ccg tgg aac ctg gag cgg att acc 777 Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr 150 155 160 cct cca cgg tac cgg gcg gat gaa tac cag ccc ccc gac gga ggc agc 825 Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser 165 170 175 ctg gtg gag gtg tat ctc cta gac acc agc ata cag agt gac cac cgg 873 Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp His Arg 180 185 190 gaa atc gag ggc agg gtc atg gtc acc gac ttc gag aat gtg ccc gag 921 Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val Pro Glu 195 200 205 210 gag gac ggg acc cgc ttc cac aga cag gcc agc aag tgt gac agt cat 969 Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp Ser His 215 220 225 ggc acc cac ctg gca ggg gtg gtc agc ggc cgg gat gcc ggc gtg gcc 1017 Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly Val Ala 230 235 240 aag ggt gcc agc atg cgc agc ctg cgc gtg ctc aac tgc caa ggg aag 1065 Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln Gly Lys 245 250 255 ggc acg gtt agc ggc acc ctc ata ggc ctg gag ttt att cgg aaa agc 1113 Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser 260 265 270 cag ctg gtc cag cct gtg ggg cca ctg gtg gtg ctg ctg ccc ctg gcg 1161 Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro Leu Ala 275 280 285 290 ggt ggg tac agc cgc gtc ctc aac gcc gcc tgc cag cgc ctg gcg agg 1209 Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg 295 300 305 gct ggg gtc gtg ctg gtc acc gct gcc ggc aac ttc cgg gac gat gcc 1257 Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala 310 315 320 tgc ctc tac tcc cca gcc tca gct ccc gag gtc atc aca gtt ggg gcc 1305 Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val Gly Ala 325 330 335 acc aat gcc cag gac cag ccg gtg acc ctg ggg act ttg ggg acc aac 1353 Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly Thr Asn 340 345 350 ttt ggc cgc tgt gtg gac ctc ttt gcc cca ggg gag gac atc att ggt 1401 Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly 355 360 365 370 gcc tcc agc gac tgc agc acc tgc ttt gtg tca cag agt ggg aca tca 1449 Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly Thr Ser 375 380 385 cag gct gct gcc cac gtg gct ggc att gca gcc atg atg ctg tct gcc 1497 Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu Ser Ala 390 395 400 gag ccg gag ctc acc ctg gcc gag ttg agg cag aga ctg atc cac ttc 1545 Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile His Phe 405 410 415 tct gcc aaa gat gcc atc aat gag gcc tgg ttc cct gag gac cag cgg 1593 Ser Ala Lys Asp Ala Ile Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg 420 425 430 gta ctg acc ccc aac ctg gtg gcc gcc ctg ccc ccc agc acc cat ggg 1641 Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr His Gly 435 440 445 450 gca ggt tgg cag ctg ttt tgc agg act gtg tgg tca gca cac tcg ggg 1689 Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His Ser Gly 455 460 465 cct aca cgg atg gcc aca gcc atc gcc cgc tgc gcc cca gat gag gag 1737 Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp Glu Glu 470 475 480 ctg ctg agc tgc tcc agt ttc tcc agg agt gga agc ggc ggg gcg agc 1785 Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Ser Gly Gly Ala Ser 485 490 495 gca tgg agg ccc aag ggg gca agc tgg tct gcc ggg ccc aca acg ctt 1833 Ala Trp Arg Pro Lys Gly Ala Ser Trp Ser Ala Gly Pro Thr Thr Leu 500 505 510 ttg ggg gtg agg gtg tct acg cca ttg cca ggt gct gcc tgc tac ccc 1881 Leu Gly Val Arg Val Ser Thr Pro Leu Pro Gly Ala Ala Cys Tyr Pro 515 520 525 530 agg cca act gca gcg tcc aca cag ctc cac cag ctg agg cca gca tgg 1929 Arg Pro Thr Ala Ala Ser Thr Gln Leu His Gln Leu Arg Pro Ala Trp 535 540 545 gga ccc gtg tcc act gcc acc aac agg gcc acg tcc tca cag gct gca 1977 Gly Pro Val Ser Thr Ala Thr Asn Arg Ala Thr Ser Ser Gln Ala Ala 550 555 560 gct ccc act ggg agg tgg agg acc ttg gca ccc aca agc cgc ctg tgc 2025 Ala Pro Thr Gly Arg Trp Arg Thr Leu Ala Pro Thr Ser Arg Leu Cys 565 570 575 tgaggccacg aggtcagccc aaccagtgcg tgggccacag ggaggccagc atccacgctt 2085 cctgctgcca tgccccaggt ctggaatgca aagtcaagga gcatggaatc ccggcccctc 2145 aggagcaggt gaccgtggcc tgcgaggagg gctggaccct gactggctgc agtgccctcc 2205 ctgggacctc ccacgtcctg ggggcctacg ccgtagacaa cacgtgtgta gtcaggagcc 2265 gggacgtcag cactacaggc agcaccagcg aagaggccgt gacagccgtt gccatctgct 2325 gccggagccg gcacctggcg caggcctccc aggagctcca gtgacagccc catcccagga 2385 tgggtgtctg gggagggtca agggctgggg ctgagcttta aaatggttcc gacttgtccc 2445 tctctcagcc ctccatggcc tggcacgagg ggatggggat gcttccgcct tcccggggct 2505 gctggcctgg cccttgagtg gggcagcctc cttgcctgga actcactcac tctgggtgcc 2565 tcctccccag gtggaggtgc caggaagctc cctccctcac tgtggggcat ttcaccattc 2625 aaacaggtcg agctgtgctc gggtgctgcc agctgctccc aatgtgccga tgtccgtggg 2685 cagaatgact tttattgagc tcttgttccg tgccaggcat tcaatcctca ggtctccacc 2745 aaggaggcag gattcttccc atggataggg gagggggcgg taggggctgc agggacaaac 2805 atcgttgggg ggtgagtgtg aaaggtgctg atggccctca tctccagcta actgtggaga 2865 agcccctggg ggctccctga ttaatggagg cttagctttc tggatggcat ctagccagag 2925 gctggagaca ggtgtgcccc tggtggtcac aggctgtgcc ttggtttcct gagccacctt 2985 tactctgctc tatgccaggc tgtgctagca acacccaaag gtggcctgcg gggagccatc 3045 acctaggact gactcggcag tgtgcagtgg tgcatgcact gtctcagcca acccgctcca 3105 ctacccggca gggtacacat tcgcacccct acttcacaga ggaagaaacc tggaaccaga 3165 gggggcgtgc ctgccaagct cacacagcag gaactgggcc agaaacgcag attgggctgg 3225 ctctgaagcc aagcctcttc ttacttcacc cggctgggct cctcattttt acgggtaaca 3285 gtgaggctgg gaaggggaac acagaccagg aagctcggtg agtgatggca gaacgatgcc 3345 tgcaggcatg gaactttttc cgttatcacc caggcctgat tcactggcct ggcggagatg 3405 cttctaaggc atggtcgggg gagagggcca acaactgtcc ctccttgagc accagcccca 3465 cccaagcaag cagacattta tcttttgggt ctgtcctctc tgttgccttt ttacagccaa 3525 cttttctaga cctgttttgc ttttgtaact tgaagatatt tattctgggt tttgtagcat 3585 ttttattaat atggtgactt tttaaaataa aaacaaacaa acgttgtcct 3635 <210> 46 <211> 578 <212> PRT <213> Homo sapiens <400> 46 Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 1 5 10 15 Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 20 25 30 Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 35 40 45 Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 50 55 60 His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 65 70 75 80 Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 85 90 95 Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 100 105 110 His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 115 120 125 Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 130 135 140 Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 145 150 155 160 Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 165 170 175 Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 180 185 190 His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 195 200 205 Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 210 215 220 Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 225 230 235 240 Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 245 250 255 Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 260 265 270 Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 275 280 285 Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 290 295 300 Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 305 310 315 320 Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 325 330 335 Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 340 345 350 Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 355 360 365 Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 370 375 380 Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 385 390 395 400 Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 405 410 415 His Phe Ser Ala Lys Asp Ala Ile Asn Glu Ala Trp Phe Pro Glu Asp 420 425 430 Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 435 440 445 His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 450 455 460 Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp 465 470 475 480 Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Ser Gly Gly 485 490 495 Ala Ser Ala Trp Arg Pro Lys Gly Ala Ser Trp Ser Ala Gly Pro Thr 500 505 510 Thr Leu Leu Gly Val Arg Val Ser Thr Pro Leu Pro Gly Ala Ala Cys 515 520 525 Tyr Pro Arg Pro Thr Ala Ala Ser Thr Gln Leu His Gln Leu Arg Pro 530 535 540 Ala Trp Gly Pro Val Ser Thr Ala Thr Asn Arg Ala Thr Ser Ser Gln 545 550 555 560 Ala Ala Ala Pro Thr Gly Arg Trp Arg Thr Leu Ala Pro Thr Ser Arg 565 570 575 Leu Cys <210> 47 <211> 2366 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (50)..(904) <400> 47 gagcgagcga gcgagcgagt tgccgagcgc gccccgtccc tcgcgcgcg atg ctc ccc 58 Met Leu Pro 1 tgg acg gcg ctc ggc ctg gcc ctg agc ttg cgg ctg gcg ctg gcg cgg 106 Trp Thr Ala Leu Gly Leu Ala Leu Ser Leu Arg Leu Ala Leu Ala Arg 5 10 15 agc ggc gcg gag cgc ggt cca cca gca tcg gcc ccc cga ggg gac ctg 154 Ser Gly Ala Glu Arg Gly Pro Pro Ala Ser Ala Pro Arg Gly Asp Leu 20 25 30 35 atg ttc ctg ctg gac agc tca gcc agc gtc tct cac tac gag ttc tcc 202 Met Phe Leu Leu Asp Ser Ser Ala Ser Val Ser His Tyr Glu Phe Ser 40 45 50 cgg gtt cgg gag ttt gtg ggg cag ctg gtg gct cca ctg ccc ctg ggc 250 Arg Val Arg Glu Phe Val Gly Gln Leu Val Ala Pro Leu Pro Leu Gly 55 60 65 acc ggg gcc ctg cgt gcc agt ctg gtg cac gtg ggc agt cgg cca tac 298 Thr Gly Ala Leu Arg Ala Ser Leu Val His Val Gly Ser Arg Pro Tyr 70 75 80 acc gag ttc ccc ttc ggc cag cac agc tcg ggt gag gct gcc cag gat 346 Thr Glu Phe Pro Phe Gly Gln His Ser Ser Gly Glu Ala Ala Gln Asp 85 90 95 gcg gtg cgt gct tct gcc cag cgc atg ggt gac acc cac act ggc ctg 394 Ala Val Arg Ala Ser Ala Gln Arg Met Gly Asp Thr His Thr Gly Leu 100 105 110 115 gcg ctg gtc tat gcc aag gaa cag ctg ttt gct gaa gca tca ggt gcc 442 Ala Leu Val Tyr Ala Lys Glu Gln Leu Phe Ala Glu Ala Ser Gly Ala 120 125 130 cgg cca ggg gtg ccc aaa gtg ctg gtg tgg gtg aca gat ggc ggc tcc 490 Arg Pro Gly Val Pro Lys Val Leu Val Trp Val Thr Asp Gly Gly Ser 135 140 145 agc gac cct gtg ggc ccc ccc atg cag gag ctc aag gac ctg ggc gtc 538 Ser Asp Pro Val Gly Pro Pro Met Gln Glu Leu Lys Asp Leu Gly Val 150 155 160 acc gtg ttc att gtc agc acc ggc cga ggc aac ttc ctg gag ctg tca 586 Thr Val Phe Ile Val Ser Thr Gly Arg Gly Asn Phe Leu Glu Leu Ser 165 170 175 gcc gct gcc tca gcc cct gcc gag aag cac ctg cac ttt gtg gac gtg 634 Ala Ala Ala Ser Ala Pro Ala Glu Lys His Leu His Phe Val Asp Val 180 185 190 195 gat gac ctg cac atc att gtc caa gag ctg agg ggc tcc att ctc gac 682 Asp Asp Leu His Ile Ile Val Gln Glu Leu Arg Gly Ser Ile Leu Asp 200 205 210 gcg atg cgg ccg cag cag ctc cat gcc acg gag atc acg tcc agc ggc 730 Ala Met Arg Pro Gln Gln Leu His Ala Thr Glu Ile Thr Ser Ser Gly 215 220 225 ttc cgc ctg gcc tgg cca ccc ctg ctg acc gca gac tcg ggc tac tat 778 Phe Arg Leu Ala Trp Pro Pro Leu Leu Thr Ala Asp Ser Gly Tyr Tyr 230 235 240 gtg ctg ggg ctg gtg ccc agc gcc cag ccg ggg ggc tgc aag acg cca 826 Val Leu Gly Leu Val Pro Ser Ala Gln Pro Gly Gly Cys Lys Thr Pro 245 250 255 gca gct gcc agg gaa cgc cac gga ctg gat ctg ggc cgg cct cga ccc 874 Ala Ala Ala Arg Glu Arg His Gly Leu Asp Leu Gly Arg Pro Arg Pro 260 265 270 275 gga cac gga cta cga cgt ggc gct agt gcc tgagtccaac gtgcgcctcc 924 Gly His Gly Leu Arg Arg Gly Ala Ser Ala 280 285 tgaggcccca gatcctgcgg gtgcgcacgc ggcccggtga ggcagggccg ggggcttcgg 984 gcccggagtc gggggctggg ccggccccca cgcagctcgc cgccctcccc gccccagagg 1044 aggccgggcc ggagcgcatc gtcatctccc acgcccggcc gcgcagcctc cgcgtgagtt 1104 gggccccagc gctgggctca gccgcggcgc tcggctacca cgtgcagttc gggccgctgc 1164 ggggcgggga ggcgcagcgg gtggaggtgc ccgcgggccg caactgcacc acgctgcagg 1224 gcctggcgcc gggcaccgcc tacctggtga ccgtgaccgc cgccttccgc tcgggccgcg 1284 agagcgcgct gtccgccaag gcctgcacgc ccgacggccc gcgcccgcgc ccacgccccg 1344 tgccccgcgc cccgaccccg gggaccgcca gccgtgagcc gtaagccagc gtccccgccc 1404 acccgagagg gccggcgcct acctgagggc ccctgtgtcc cgaacccgga gcggaggcgc 1464 ccaacccggc agacgggtgc aggcccggcc tttccccacg cggactccgc gcgaccccgg 1524 ccctctccct gcggccgcag ggcttccccg cctggcgcct gccctccagg gctggggcct 1584 cgcctggcgg gaccccgcag cagccccggc cccatccccg cccagagccg ggcgtcgtgt 1644 gggtccgtgg gtgataatag agagcgtcag acccaggact gttcagggag gagccccggt 1704 cagactccca cgtgtgaaga ccgggcccca agtggcaagg gctggcctgg ggcgggcagc 1764 ttgggtcctg gacgttgata ggaagcggaa ggggaatcgc gggaagctgg cccaggtcag 1824 gtccgcaaag gcttctgaag aagaggaagg gcgagtaggg gcacctggac gctgatggtg 1884 gccaggatgc tcagctggcc aggagggcag cacctgctgg ggacggtggc cctgccttca 1944 tgcccaggac accagctggg tccagctagc agccactggg aatcagagga atggggcaga 2004 gctgggcatt caggaccttg aggacaggtg accccacccg cccaccgcca ctatcaggcc 2064 ccgggaccgc actgacagga aaccttccgt cgtgagggag cacttcccag gggccgcagg 2124 gacgacactc tccagggagg ccccagcaac cacaccatct tcttgctgtg agaggtctca 2184 ccccgggcta cctcctgtca ctactcactg ccctggggtc cgtgggcaag ttgcccaggg 2244 tgggggtgcc tagccaggtg cagtccccgc cccgcctagt cctcggcgtc acgcaatgct 2304 cacctcgcct cttccccact aacatcccag actttaaaat tcagtaaatc agatgtacac 2364 cg 2366 <210> 48 <211> 285 <212> PRT <213> Homo sapiens <400> 48 Met Leu Pro Trp Thr Ala Leu Gly Leu Ala Leu Ser Leu Arg Leu Ala 1 5 10 15 Leu Ala Arg Ser Gly Ala Glu Arg Gly Pro Pro Ala Ser Ala Pro Arg 20 25 30 Gly Asp Leu Met Phe Leu Leu Asp Ser Ser Ala Ser Val Ser His Tyr 35 40 45 Glu Phe Ser Arg Val Arg Glu Phe Val Gly Gln Leu Val Ala Pro Leu 50 55 60 Pro Leu Gly Thr Gly Ala Leu Arg Ala Ser Leu Val His Val Gly Ser 65 70 75 80 Arg Pro Tyr Thr Glu Phe Pro Phe Gly Gln His Ser Ser Gly Glu Ala 85 90 95 Ala Gln Asp Ala Val Arg Ala Ser Ala Gln Arg Met Gly Asp Thr His 100 105 110 Thr Gly Leu Ala Leu Val Tyr Ala Lys Glu Gln Leu Phe Ala Glu Ala 115 120 125 Ser Gly Ala Arg Pro Gly Val Pro Lys Val Leu Val Trp Val Thr Asp 130 135 140 Gly Gly Ser Ser Asp Pro Val Gly Pro Pro Met Gln Glu Leu Lys Asp 145 150 155 160 Leu Gly Val Thr Val Phe Ile Val Ser Thr Gly Arg Gly Asn Phe Leu 165 170 175 Glu Leu Ser Ala Ala Ala Ser Ala Pro Ala Glu Lys His Leu His Phe 180 185 190 Val Asp Val Asp Asp Leu His Ile Ile Val Gln Glu Leu Arg Gly Ser 195 200 205 Ile Leu Asp Ala Met Arg Pro Gln Gln Leu His Ala Thr Glu Ile Thr 210 215 220 Ser Ser Gly Phe Arg Leu Ala Trp Pro Pro Leu Leu Thr Ala Asp Ser 225 230 235 240 Gly Tyr Tyr Val Leu Gly Leu Val Pro Ser Ala Gln Pro Gly Gly Cys 245 250 255 Lys Thr Pro Ala Ala Ala Arg Glu Arg His Gly Leu Asp Leu Gly Arg 260 265 270 Pro Arg Pro Gly His Gly Leu Arg Arg Gly Ala Ser Ala 275 280 285 <210> 49 <211> 2147 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (130)..(1122) <400> 49 ccagtgagag cggctttcca ggacggtgcg atgtgctgcg cagcgaagag gcaggaggcc 60 ggcttcctgg ggtagcggta caggcgggcg cttactctgt gcgcttgctt ccccaaccct 120 gcaccggcc atg cgc ccg gcc ttg gcg gtg ggc ctg gtg ttc gca ggc tgc 171 Met Arg Pro Ala Leu Ala Val Gly Leu Val Phe Ala Gly Cys 1 5 10 tgc agt aac gtg atc ttc cta gag ctc ctg gcc cgg aag cat cca gga 219 Cys Ser Asn Val Ile Phe Leu Glu Leu Leu Ala Arg Lys His Pro Gly 15 20 25 30 tgt ggg aac att gtg aca ttt gca caa ttt tta ttt att gct gtg gaa 267 Cys Gly Asn Ile Val Thr Phe Ala Gln Phe Leu Phe Ile Ala Val Glu 35 40 45 ggc ttc ctc ttt gaa gct gat ttg gga agg aag cca cca gct atc cca 315 Gly Phe Leu Phe Glu Ala Asp Leu Gly Arg Lys Pro Pro Ala Ile Pro 50 55 60 ata agg tac tat gcc ata atg gtg acc atg ttc ttc acc gtg agc gtg 363 Ile Arg Tyr Tyr Ala Ile Met Val Thr Met Phe Phe Thr Val Ser Val 65 70 75 gtg aac aac tat gcc ctg aat ctc aac att gcc atg ccc ctg cat atg 411 Val Asn Asn Tyr Ala Leu Asn Leu Asn Ile Ala Met Pro Leu His Met 80 85 90 ata ttt aga tcc ggt tct cta att gcc aac atg att cta gga att atc 459 Ile Phe Arg Ser Gly Ser Leu Ile Ala Asn Met Ile Leu Gly Ile Ile 95 100 105 110 att ttg aag aaa aga tac agt ata ttc aaa tat acc tcc att gcc ctg 507 Ile Leu Lys Lys Arg Tyr Ser Ile Phe Lys Tyr Thr Ser Ile Ala Leu 115 120 125 gtg tct gtg ggg ata ttt att tgc act ttt atg tca gca aag cag gtg 555 Val Ser Val Gly Ile Phe Ile Cys Thr Phe Met Ser Ala Lys Gln Val 130 135 140 act tcc cag tcc agc ttg agt gag aat gat gga ttc cag gca ttt gtg 603 Thr Ser Gln Ser Ser Leu Ser Glu Asn Asp Gly Phe Gln Ala Phe Val 145 150 155 tgg tgg tta cta ggt att ggg gca ttg act ttt gct ctt ctg atg tca 651 Trp Trp Leu Leu Gly Ile Gly Ala Leu Thr Phe Ala Leu Leu Met Ser 160 165 170 gca agg atg ggg ata ttc caa gag act ctc tac aaa cga ttt ggg aaa 699 Ala Arg Met Gly Ile Phe Gln Glu Thr Leu Tyr Lys Arg Phe Gly Lys 175 180 185 190 cac tcc aag gag gct ttg ttt tat aat cac gcc ctt cca ctt ccg ggt 747 His Ser Lys Glu Ala Leu Phe Tyr Asn His Ala Leu Pro Leu Pro Gly 195 200 205 ttc gtc ttc ttg gct tct gat att tat gac cat gca gtt cta ttc aat 795 Phe Val Phe Leu Ala Ser Asp Ile Tyr Asp His Ala Val Leu Phe Asn 210 215 220 aag tct gag tta tat gaa att ccc gtc atc gga gtg acc ctg ccc atc 843 Lys Ser Glu Leu Tyr Glu Ile Pro Val Ile Gly Val Thr Leu Pro Ile 225 230 235 atg tgg ttc tac ctc ctc atg aac atc atc act cag tac gtg tgc atc 891 Met Trp Phe Tyr Leu Leu Met Asn Ile Ile Thr Gln Tyr Val Cys Ile 240 245 250 cgg ggt gtg ttt atc ctc acc aca gaa tgc gcc tcc ctc acc gtc acg 939 Arg Gly Val Phe Ile Leu Thr Thr Glu Cys Ala Ser Leu Thr Val Thr 255 260 265 270 ctc gtc gtg acc cta cgc aaa ttt gtg agc ctc atc ttt tcc atc ttg 987 Leu Val Val Thr Leu Arg Lys Phe Val Ser Leu Ile Phe Ser Ile Leu 275 280 285 tac ttc cag aac ccc ttc acc ctg tgg cac tgg ctg ggc acc ttg ttt 1035 Tyr Phe Gln Asn Pro Phe Thr Leu Trp His Trp Leu Gly Thr Leu Phe 290 295 300 gtc ttc att ggg acc tta atg tac aca gag gtg tgg aac aac cta ggg 1083 Val Phe Ile Gly Thr Leu Met Tyr Thr Glu Val Trp Asn Asn Leu Gly 305 310 315 acc aca aaa agt gag cct cag aag gac agc aag aag aac tgaggcctgt 1132 Thr Thr Lys Ser Glu Pro Gln Lys Asp Ser Lys Lys Asn 320 325 330 ctggagtacg tagaccagtg tcgtcgtgag ggtgggaccc tgtgaaggtc tgaccaccgt 1192 ttcgcttttg ttaatgccga gctacccgca gtgctgagcc agccgtgcaa aaggaaatct 1252 tcaggagggg acttctcacg ttgctcagac tgacacatgt agactaaata gaaacccctc 1312 agccctaaaa tagaaaaaag aacagttctg gactattgaa cagcccattc atttatttct 1372 gttttgttta ccgacatatt cagtattatt cttgttttct gaattctgag tctcctgaac 1432 aaaaggctta ctatccatgg tcttggaaaa gattgtccct tctcttgctg ttgtaatgca 1492 tctctgctac agcagtcatt gtcatcctgt gaccttatcc cttttgtctc ccatcacctt 1552 ttccttcttc agcagcacct cacagtcagt cagacgctgc aggcaccact atcaccagga 1612 gtggccaagt aaaccgagac accagtaaca gcagggctgg acttcctcca gcgttttggg 1672 aaggaaagag atgttcccct gagctgattc ccagtgacag tgcagcaaga ctagtgggac 1732 tcctctttcc cacattttgc tttttttttt ttctatgcaa aagtcagatg cttctatcca 1792 ttgctttctg tgattagggc ggccctgcag catatctcac agcagacaca gtgttcataa 1852 caaagaaagg ttgtgccggg cacggtggct cacacctgta atcccagccc tttgggaggc 1912 tgaggtgggt gtatcacttg aggtcaggag ttcaagacca atctggccaa catggtgaaa 1972 ccccatctct actaaaaata cgaaaattag ctgggtgtga tggcgcatgc ctgtaatccc 2032 agctacttgg gaggctgagg caggagaatc acttgaaccc gggagatgaa ggttgcagtg 2092 agctgaggtc gtgctactgc actcccgcct gggtgacaga gtgagactct atctc 2147 <210> 50 <211> 331 <212> PRT <213> Homo sapiens <400> 50 Met Arg Pro Ala Leu Ala Val Gly Leu Val Phe Ala Gly Cys Cys Ser 1 5 10 15 Asn Val Ile Phe Leu Glu Leu Leu Ala Arg Lys His Pro Gly Cys Gly 20 25 30 Asn Ile Val Thr Phe Ala Gln Phe Leu Phe Ile Ala Val Glu Gly Phe 35 40 45 Leu Phe Glu Ala Asp Leu Gly Arg Lys Pro Pro Ala Ile Pro Ile Arg 50 55 60 Tyr Tyr Ala Ile Met Val Thr Met Phe Phe Thr Val Ser Val Val Asn 65 70 75 80 Asn Tyr Ala Leu Asn Leu Asn Ile Ala Met Pro Leu His Met Ile Phe 85 90 95 Arg Ser Gly Ser Leu Ile Ala Asn Met Ile Leu Gly Ile Ile Ile Leu 100 105 110 Lys Lys Arg Tyr Ser Ile Phe Lys Tyr Thr Ser Ile Ala Leu Val Ser 115 120 125 Val Gly Ile Phe Ile Cys Thr Phe Met Ser Ala Lys Gln Val Thr Ser 130 135 140 Gln Ser Ser Leu Ser Glu Asn Asp Gly Phe Gln Ala Phe Val Trp Trp 145 150 155 160 Leu Leu Gly Ile Gly Ala Leu Thr Phe Ala Leu Leu Met Ser Ala Arg 165 170 175 Met Gly Ile Phe Gln Glu Thr Leu Tyr Lys Arg Phe Gly Lys His Ser 180 185 190 Lys Glu Ala Leu Phe Tyr Asn His Ala Leu Pro Leu Pro Gly Phe Val 195 200 205 Phe Leu Ala Ser Asp Ile Tyr Asp His Ala Val Leu Phe Asn Lys Ser 210 215 220 Glu Leu Tyr Glu Ile Pro Val Ile Gly Val Thr Leu Pro Ile Met Trp 225 230 235 240 Phe Tyr Leu Leu Met Asn Ile Ile Thr Gln Tyr Val Cys Ile Arg Gly 245 250 255 Val Phe Ile Leu Thr Thr Glu Cys Ala Ser Leu Thr Val Thr Leu Val 260 265 270 Val Thr Leu Arg Lys Phe Val Ser Leu Ile Phe Ser Ile Leu Tyr Phe 275 280 285 Gln Asn Pro Phe Thr Leu Trp His Trp Leu Gly Thr Leu Phe Val Phe 290 295 300 Ile Gly Thr Leu Met Tyr Thr Glu Val Trp Asn Asn Leu Gly Thr Thr 305 310 315 320 Lys Ser Glu Pro Gln Lys Asp Ser Lys Lys Asn 325 330 <210> 51 <211> 2863 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (231)..(920) <400> 51 tctccctctc caggggcatc tccccctcca aggctctgca aagaactgcc ctgtcttcta 60 gatgccttct tgaggctgct tgtggccacc cacagacact tgtaaggagg agagaagtca 120 gcctggcaga gagactctga aatgagggat tagaggtgtt caaggagcaa gagcttcagc 180 ctggagacaa gggagcagtc cctgaagacg cttctactga gaggtctgcc atg gcc 236 Met Ala 1 tct ctt ggc ctc caa ctt gtg ggc tac atc cta ggc ctt ctg ggg ctt 284 Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu Gly Leu 5 10 15 ttg ggc aca ctg gtt gcc atg ctg ctc ccc agc tgg aaa aca agt tct 332 Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr Ser Ser 20 25 30 tat gtc ggt gcc agc att gtg aca gca gtt ggc ttc tcc aag ggc ctc 380 Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys Gly Leu 35 40 45 50 tgg atg gaa tgt gcc aca cac agc aca ggc atc acc cag tgt gac atc 428 Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys Asp Ile 55 60 65 tat agc acc ctt ctg ggc ctg ccc gct gac atc cag gct gcc cag gcc 476 Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala Gln Ala 70 75 80 atg atg gtg aca tcc agt gca atc tcc tcc ctg gcc tgc att atc tct 524 Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile Ile Ser 85 90 95 gtg gtg ggc atg aga tgc aca gtc ttc tgc cag gaa tcc cga gcc aaa 572 Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg Ala Lys 100 105 110 gac aga gtg gcg gta gca ggt gga gtc ttt ttc atc ctt gga ggc ctc 620 Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly Gly Leu 115 120 125 130 ctg gga ttc att cct gtt gcc tgg aat ctt cat ggg atc cta cgg gac 668 Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu Arg Asp 135 140 145 ttc tac tca cca ctg gtg cct gac agc atg aaa ttt gag att gga gag 716 Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile Gly Glu 150 155 160 gct ctt tac ttg ggc att att tct tcc ctg ttc tcc ctg ata gct gga 764 Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile Ala Gly 165 170 175 atc atc ctc tgc ttt tcc tgc tca tcc cag aga aat cgc tcc aac tac 812 Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser Asn Tyr 180 185 190 tac gat gcc tac caa gcc caa cct ctt gcc aca agg agc tct cca agg 860 Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser Pro Arg 195 200 205 210 cct ggt caa cct ccc aaa gtc aag agt gag ttc aat tcc tac agc ctg 908 Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr Ser Leu 215 220 225 aca ggg tat gtg tgaagaacca ggggccagag ctggggggtg gctgggtctg 960 Thr Gly Tyr Val 230 tgaaaaacag tggacagcac cccgagggcc acaggtgagg gacactacca ctggatcgtg 1020 tcagaaggtg ctgctgagga tagactgact ttggccattg gattgagcaa aggcagaaat 1080 gggggctagt gtaacagcat gcaggttgaa ttgccaagga tgctcgccat gccagccttt 1140 ctgttttcct caccttgctg ctcccctgcc ctaagtcccc aaccctcaac ttgaaacccc 1200 attcccttaa gccaggactc agaggatccc tttgccctct ggtttacctg ggactccatc 1260 cccaaaccca ctaatcacat cccactgact gaccctctgt gatcaaagac cctctctctg 1320 gctgaggttg gctcttagct cattgctggg gatgggaagg agaagcagtg gcttttgtgg 1380 gcattgctct aacctacttc tcaagcttcc ctccaaagaa actgattggc cctggaacct 1440 ccatcccact cctgttatga ctccacagtg tccagactaa tttgtgcatg aactgaaata 1500 aaaccatcct acggtatcca gggaacagaa agcaggatgc aggatgggag gacaggaagg 1560 cagcctggga catttaaaaa attaaaaatg aaaaaaaaac ccagaaccca tttctcaggg 1620 cactttccag aattctctca tatttgtggg ctgggatcaa gcctgcagct tgaggaaagc 1680 acaaggaaag gaaagaagat ctggtggaaa gctcaggtgg cagcggactc tgactccact 1740 gaggaactgc ctcagaagct gcgatcacaa ctttggctga agcccctgcc tcactctagg 1800 gcacctgacc tggcctcttg cctaaaccac aaggctaagg gctatagaca atggtttcct 1860 taggaacagt aaaccagttt ttctagggat ggcccttggc tgggggatga cagtgtggga 1920 gctgtggggt actgaggaag acaccattcc ttgacggtgt ctaagaagcc aggtggatgt 1980 gtgtggtggc tccagtgggt gtttctactc tgccagtgag aggcagcccc ctagaaactc 2040 ttcaggcgta atggaaaatc agctcaaatg agatcaggcc cccccagggt ccacccacag 2100 agcactacag agcctctgaa agaccatagc accaagcgag ccccttcaga ttcccccact 2160 gtccatcgga agatgctcca gagtggctag agggcatcta agggctccag catggcatat 2220 ccatgcccac ggtgctgtgt ccatgatctg agtgatagct gcactgctgc ctgggattgc 2280 agctgaggtg ggagtggaga atggttccca ggaagacagt tccacctcta aggtccgaaa 2340 atgttccctt taccctggag tgggagtgag gggtcataca ccaaaggtat tttccctcac 2400 cagtctaggc atgactggct tctgaaaaat tccagcacac ctcctcgaac ctcattgtca 2460 gcagagaggg cccatctgtt gtctgtaaca tgcctttcac atgtccacct tcttgccatg 2520 ttccagctgc tctcccaacc tggaaggccg tctcccctta gccaagtcct cctcaggctt 2580 ggagaacttc ctcagcgtca cctccttcat tgagccttct ctgatcaccc catccctctc 2640 ctacccctcc ctcccccaac cctcaatgta taaattgctt cttgatgctt agcattcaca 2700 atttttgatt gatcgttatt tgtgtgtgtg tgtccgatct cacaagtata ttgtaaaccc 2760 ttcggtgggt gggggccata tcctagacct ctctgtatcc cccagactat ctgtaacagt 2820 gccaggcaca cagtaggtga tcaataaaca cttgttgatt gag 2863 <210> 52 <211> 230 <212> PRT <213> Homo sapiens <400> 52 Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu 1 5 10 15 Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr 20 25 30 Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys 35 40 45 Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys 50 55 60 Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala 65 70 75 80 Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile 85 90 95 Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg 100 105 110 Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly 115 120 125 Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu 130 135 140 Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile 145 150 155 160 Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile 165 170 175 Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser 180 185 190 Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser 195 200 205 Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr 210 215 220 Ser Leu Thr Gly Tyr Val 225 230 <210> 53 <211> 1931 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (32)..(1423) <400> 53 gcggtcacgt gactgctgcg ggccagccaa g atg gcg gcc tca tgc ttg gtc 52 Met Ala Ala Ser Cys Leu Val 1 5 ctg ctg gcg ctg tgt ctg ctg ctg ccg ctg ctg ctg ctg gga gga tgg 100 Leu Leu Ala Leu Cys Leu Leu Leu Pro Leu Leu Leu Leu Gly Gly Trp 10 15 20 aag cgc tgg cgc cgg ggg cgg gcg gcc cgg cat gta gta gcg gtg gtg 148 Lys Arg Trp Arg Arg Gly Arg Ala Ala Arg His Val Val Ala Val Val 25 30 35 ctg ggc gac gtg ggc cgc agc ccc cgt atg cag tac cac gcg ctg tcg 196 Leu Gly Asp Val Gly Arg Ser Pro Arg Met Gln Tyr His Ala Leu Ser 40 45 50 55 ttg gcc atg cac ggc ttc tcg gtg acc ctc ctg ggg ttc tgc aac tcc 244 Leu Ala Met His Gly Phe Ser Val Thr Leu Leu Gly Phe Cys Asn Ser 60 65 70 aaa ccc cat gat gag ctc ttg cag aac aac aga att cag att gtg ggg 292 Lys Pro His Asp Glu Leu Leu Gln Asn Asn Arg Ile Gln Ile Val Gly 75 80 85 ttg aca gaa ctt cag agt ctt gca gtt ggg ccc cgg gtt ttc cag tac 340 Leu Thr Glu Leu Gln Ser Leu Ala Val Gly Pro Arg Val Phe Gln Tyr 90 95 100 gga gtc aaa gtt gta ctt cag gct atg tac ttg ctg tgg aag ctg atg 388 Gly Val Lys Val Val Leu Gln Ala Met Tyr Leu Leu Trp Lys Leu Met 105 110 115 tgg agg gag cca ggt gcc tat atc ttt ctc cag aac ccc cca ggt ctg 436 Trp Arg Glu Pro Gly Ala Tyr Ile Phe Leu Gln Asn Pro Pro Gly Leu 120 125 130 135 ccg agc att gct gtc tgc tgg ttc gtg ggc tgc ctt tgt gga agc aag 484 Pro Ser Ile Ala Val Cys Trp Phe Val Gly Cys Leu Cys Gly Ser Lys 140 145 150 ctc gtc att gac tgg cac aac tat ggc tac tcc atc atg ggt ctg gtg 532 Leu Val Ile Asp Trp His Asn Tyr Gly Tyr Ser Ile Met Gly Leu Val 155 160 165 cat ggc ccc aac cat ccc ctc gtt ctg ctg gcc aag tgg tac gag aag 580 His Gly Pro Asn His Pro Leu Val Leu Leu Ala Lys Trp Tyr Glu Lys 170 175 180 ttc ttt ggg cgc ctg tcc cac ctg aac ctg tgt gtt acc aat gct atg 628 Phe Phe Gly Arg Leu Ser His Leu Asn Leu Cys Val Thr Asn Ala Met 185 190 195 cga gaa gac ctg gcg gat aac tgg cac atc agg gct gtg acc gtc tac 676 Arg Glu Asp Leu Ala Asp Asn Trp His Ile Arg Ala Val Thr Val Tyr 200 205 210 215 gac aag ccc gca tct ttc ttt aaa gag aca cct ctg gac ctg cag cac 724 Asp Lys Pro Ala Ser Phe Phe Lys Glu Thr Pro Leu Asp Leu Gln His 220 225 230 cgg ctc ttc atg aag ctg ggc agc atg cac tct ccg ttc agg gcc cgc 772 Arg Leu Phe Met Lys Leu Gly Ser Met His Ser Pro Phe Arg Ala Arg 235 240 245 tca gaa cct gag gac cca gtc acg gag cgg tcg gcc ttc acg gag cgg 820 Ser Glu Pro Glu Asp Pro Val Thr Glu Arg Ser Ala Phe Thr Glu Arg 250 255 260 gat gct ggg agc ggg ctg gtg acg cgt ctc cgt gag cgg cca gcc ctg 868 Asp Ala Gly Ser Gly Leu Val Thr Arg Leu Arg Glu Arg Pro Ala Leu 265 270 275 ctg gtc agc agc acg agc tgg aca gag gac gaa gac ttc tcc atc ctg 916 Leu Val Ser Ser Thr Ser Trp Thr Glu Asp Glu Asp Phe Ser Ile Leu 280 285 290 295 ctg gca gct tta gaa aag ttt gaa caa ctg act ctt gat gga cac aac 964 Leu Ala Ala Leu Glu Lys Phe Glu Gln Leu Thr Leu Asp Gly His Asn 300 305 310 ctt cct tct ctc gtc tgt gtg ata aca ggc aaa ggg cct ctg agg gag 1012 Leu Pro Ser Leu Val Cys Val Ile Thr Gly Lys Gly Pro Leu Arg Glu 315 320 325 tat tat agc cgc ctc atc cac cag aag cac ttc cag cac atc cag gtc 1060 Tyr Tyr Ser Arg Leu Ile His Gln Lys His Phe Gln His Ile Gln Val 330 335 340 tgc acc ccc tgg ctg gag gcc gag gac tac ccc ctg ctt cta ggg tcg 1108 Cys Thr Pro Trp Leu Glu Ala Glu Asp Tyr Pro Leu Leu Leu Gly Ser 345 350 355 gcg gac ctg ggt gtc tgt ctg cac acg tcc tcc agt ggc ctg gac ctg 1156 Ala Asp Leu Gly Val Cys Leu His Thr Ser Ser Ser Gly Leu Asp Leu 360 365 370 375 ccc atg aag gtg gtg gac atg ttt ggg tgc tgt ttg cct gtg tgt gct 1204 Pro Met Lys Val Val Asp Met Phe Gly Cys Cys Leu Pro Val Cys Ala 380 385 390 gtg aac ttc aag tgt tta cat gag ctg gtg aaa cat gaa gaa aat ggc 1252 Val Asn Phe Lys Cys Leu His Glu Leu Val Lys His Glu Glu Asn Gly 395 400 405 ctg gtc ttt gag gac tca gag gaa ctg gca gct cag ctg cag atg ctt 1300 Leu Val Phe Glu Asp Ser Glu Glu Leu Ala Ala Gln Leu Gln Met Leu 410 415 420 ttc tca aac ttt cct gat cct gcg ggc aag cta aac cag ttc cgg aag 1348 Phe Ser Asn Phe Pro Asp Pro Ala Gly Lys Leu Asn Gln Phe Arg Lys 425 430 435 aac ctg cgg gag tcg cag cag ctc cga tgg gat gag agc tgg gtg cag 1396 Asn Leu Arg Glu Ser Gln Gln Leu Arg Trp Asp Glu Ser Trp Val Gln 440 445 450 455 act gtg ctc cct ttg gtt atg gac aca taactcctgg gccagaggct 1443 Thr Val Leu Pro Leu Val Met Asp Thr 460 aaaaccccag gacccctgct gtccttcccg cagcttcttc ttggagtctc agggcaaacc 1503 ctttcgagca gcacctccca gtggccagaa gctgaaatga cagcagtggt actgcctggt 1563 aaaagaattg gttctgtgac ccgggaagct ttggttggcc ttgatttctt ctctggaggc 1623 ttggaaacgc ttcctctctt cttctgttct tcacgcccca tgcccctgct agcgtattac 1683 tgttctgtga cttccctgtg acctctgcag aactcctcat cctgcgtttg gtctccaggt 1743 gtcccctttc tgccgtgttc ctaacatttt gattcctgtc ttgaaaaaag cacctgctgc 1803 accgtaagcc cagggatgtg gcagctgcag cgggcttggc tttgtgagga actgagtgtg 1863 tccacgttgg gggaacatca tacttgatac acacgttttt atttgcacaa agaaaatgct 1923 gtttttgg 1931 <210> 54 <211> 464 <212> PRT <213> Homo sapiens <400> 54 Met Ala Ala Ser Cys Leu Val Leu Leu Ala Leu Cys Leu Leu Leu Pro 1 5 10 15 Leu Leu Leu Leu Gly Gly Trp Lys Arg Trp Arg Arg Gly Arg Ala Ala 20 25 30 Arg His Val Val Ala Val Val Leu Gly Asp Val Gly Arg Ser Pro Arg 35 40 45 Met Gln Tyr His Ala Leu Ser Leu Ala Met His Gly Phe Ser Val Thr 50 55 60 Leu Leu Gly Phe Cys Asn Ser Lys Pro His Asp Glu Leu Leu Gln Asn 65 70 75 80 Asn Arg Ile Gln Ile Val Gly Leu Thr Glu Leu Gln Ser Leu Ala Val 85 90 95 Gly Pro Arg Val Phe Gln Tyr Gly Val Lys Val Val Leu Gln Ala Met 100 105 110 Tyr Leu Leu Trp Lys Leu Met Trp Arg Glu Pro Gly Ala Tyr Ile Phe 115 120 125 Leu Gln Asn Pro Pro Gly Leu Pro Ser Ile Ala Val Cys Trp Phe Val 130 135 140 Gly Cys Leu Cys Gly Ser Lys Leu Val Ile Asp Trp His Asn Tyr Gly 145 150 155 160 Tyr Ser Ile Met Gly Leu Val His Gly Pro Asn His Pro Leu Val Leu 165 170 175 Leu Ala Lys Trp Tyr Glu Lys Phe Phe Gly Arg Leu Ser His Leu Asn 180 185 190 Leu Cys Val Thr Asn Ala Met Arg Glu Asp Leu Ala Asp Asn Trp His 195 200 205 Ile Arg Ala Val Thr Val Tyr Asp Lys Pro Ala Ser Phe Phe Lys Glu 210 215 220 Thr Pro Leu Asp Leu Gln His Arg Leu Phe Met Lys Leu Gly Ser Met 225 230 235 240 His Ser Pro Phe Arg Ala Arg Ser Glu Pro Glu Asp Pro Val Thr Glu 245 250 255 Arg Ser Ala Phe Thr Glu Arg Asp Ala Gly Ser Gly Leu Val Thr Arg 260 265 270 Leu Arg Glu Arg Pro Ala Leu Leu Val Ser Ser Thr Ser Trp Thr Glu 275 280 285 Asp Glu Asp Phe Ser Ile Leu Leu Ala Ala Leu Glu Lys Phe Glu Gln 290 295 300 Leu Thr Leu Asp Gly His Asn Leu Pro Ser Leu Val Cys Val Ile Thr 305 310 315 320 Gly Lys Gly Pro Leu Arg Glu Tyr Tyr Ser Arg Leu Ile His Gln Lys 325 330 335 His Phe Gln His Ile Gln Val Cys Thr Pro Trp Leu Glu Ala Glu Asp 340 345 350 Tyr Pro Leu Leu Leu Gly Ser Ala Asp Leu Gly Val Cys Leu His Thr 355 360 365 Ser Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe Gly 370 375 380 Cys Cys Leu Pro Val Cys Ala Val Asn Phe Lys Cys Leu His Glu Leu 385 390 395 400 Val Lys His Glu Glu Asn Gly Leu Val Phe Glu Asp Ser Glu Glu Leu 405 410 415 Ala Ala Gln Leu Gln Met Leu Phe Ser Asn Phe Pro Asp Pro Ala Gly 420 425 430 Lys Leu Asn Gln Phe Arg Lys Asn Leu Arg Glu Ser Gln Gln Leu Arg 435 440 445 Trp Asp Glu Ser Trp Val Gln Thr Val Leu Pro Leu Val Met Asp Thr 450 455 460 <210> 55 <211> 1717 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (12)..(593) <400> 55 ggctcgcagc c atg gcg gcc gcc gcg ctc cca gca tgg ctg tct ctg cag 50 Met Ala Ala Ala Ala Leu Pro Ala Trp Leu Ser Leu Gln 1 5 10 tcg agg gca agg act ctg cgt gca ttc tcc act gcc gtc tac tcg gcc 98 Ser Arg Ala Arg Thr Leu Arg Ala Phe Ser Thr Ala Val Tyr Ser Ala 15 20 25 act ccg gtc ccg aca cct agc ctg ccg gaa aga aca ccc gga aat gaa 146 Thr Pro Val Pro Thr Pro Ser Leu Pro Glu Arg Thr Pro Gly Asn Glu 30 35 40 45 agg cca cca aga aga aag gca cta cct cct agg aca gag aaa atg gct 194 Arg Pro Pro Arg Arg Lys Ala Leu Pro Pro Arg Thr Glu Lys Met Ala 50 55 60 gtt gac cag gac tgg cct agt gtt tac cca gtt gca gca cca ttt aaa 242 Val Asp Gln Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro Phe Lys 65 70 75 ccc tct gca gta cct ctt cct gtt cga atg ggt tat cca gta aaa aag 290 Pro Ser Ala Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val Lys Lys 80 85 90 ggc gtg ccc atg gca aag gag gga aat cta gaa ctt tta aag att ccc 338 Gly Val Pro Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys Ile Pro 95 100 105 aat ttt ctg cat ttg act cct gta gca att aaa aag cac tgt gaa gcc 386 Asn Phe Leu His Leu Thr Pro Val Ala Ile Lys Lys His Cys Glu Ala 110 115 120 125 ctt aaa gat ttt tgc act gag tgg cca gcc gca ctg gac agt gac gag 434 Leu Lys Asp Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser Asp Glu 130 135 140 aaa tgt gag aag cat ttt cca att gaa att gac agc act gat tat gtt 482 Lys Cys Glu Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp Tyr Val 145 150 155 tca tca gga cca tct gtt cgg aac ccc aga gca cga gta gta gtc tta 530 Ser Ser Gly Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val Val Leu 160 165 170 aga gtg ccc ttt aag gag gca gaa tta cga tta tgc agt gta tct act 578 Arg Val Pro Phe Lys Glu Ala Glu Leu Arg Leu Cys Ser Val Ser Thr 175 180 185 aac agt gtt ata cca tgagtcttgg aatactgaag aatgggaaaa aagtaagact 633 Asn Ser Val Ile Pro 190 gaagcagaca tggaagagta tatatgggaa aatagctcat cagaaagaaa tatcctggaa 693 acgcttctcc agatgaaagc tgctgagaaa aatatggaaa taaataaaga agagctcctt 753 ggtactaaag aaattgaaga gtacaaaaag tctgttgtta gtcttaaaaa tgaggaggaa 813 aatgaaaatt ccatttctca gtacaaagaa tccgtgaaga gactattaaa tgtgacatga 873 attatggagt agaaaaatct gcttgattta ttaattttat gatatatgtg atcagtatct 933 aatttgatat aaaattgaaa atgttaaaaa atcatttttt ttcctcagag ttaaaattat 993 ttccctcata ctaatgcgta atggcaatga ttactccaga gttttttaat ttttacactg 1053 gggcaataga ctaggaggtc tctgatttct tcttggtcta aagtgttttg attttatttc 1113 tacataatag ctttggtatt catgtatata catgcattta attgtgattt tatcaccttt 1173 cccatttctt tccccacaag ctggcatttc agtagttgct tttgaataat ggttttggtt 1233 acctgggaag gcaggcccag aacccatttc cttgacttgc agttccgggc tgtgttcaca 1293 tgactgctgt ctagctgatg catttttcac atttgtcaac tctggttaga aacaggtcct 1353 caggagtatt ctctaacctg atattttcta aaaagatatg ttgattcaac tttgtttagc 1413 atcctacttt ctagattgtg gggctcattt tgccagggcc aagctaccag aaaagtagaa 1473 gtggagatta cctggtatgt atctctctgg gtgccccagt tagagctgcc acagctcagg 1533 aaaaagatga ggcataacga ccttgaatgt aattggagta agtgacaaaa taagaactac 1593 cctgggaaac cctgcattca atgtagctgt caattcagta tttttaagta cacctgtcag 1653 ctgtttctta ccacttcgat ggttgtgatt aatttaaaat caaaataaag gaattactga 1713 gttt 1717 <210> 56 <211> 194 <212> PRT <213> Homo sapiens <400> 56 Met Ala Ala Ala Ala Leu Pro Ala Trp Leu Ser Leu Gln Ser Arg Ala 1 5 10 15 Arg Thr Leu Arg Ala Phe Ser Thr Ala Val Tyr Ser Ala Thr Pro Val 20 25 30 Pro Thr Pro Ser Leu Pro Glu Arg Thr Pro Gly Asn Glu Arg Pro Pro 35 40 45 Arg Arg Lys Ala Leu Pro Pro Arg Thr Glu Lys Met Ala Val Asp Gln 50 55 60 Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro Phe Lys Pro Ser Ala 65 70 75 80 Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val Lys Lys Gly Val Pro 85 90 95 Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys Ile Pro Asn Phe Leu 100 105 110 His Leu Thr Pro Val Ala Ile Lys Lys His Cys Glu Ala Leu Lys Asp 115 120 125 Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser Asp Glu Lys Cys Glu 130 135 140 Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp Tyr Val Ser Ser Gly 145 150 155 160 Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val Val Leu Arg Val Pro 165 170 175 Phe Lys Glu Ala Glu Leu Arg Leu Cys Ser Val Ser Thr Asn Ser Val 180 185 190 Ile Pro <210> 57 <211> 2510 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (94)..(951) <400> 57 ttgtatgata aggcaggtaa agtgaggaaa catgcaactg aacaggaaaa aactgaagag 60 ggattaggcc ctaatataaa aagcattgtc acc atg ttg atg ctg atg cta ttg 114 Met Leu Met Leu Met Leu Leu 1 5 atg atg ttt gct gtc cac tgt acc tgg gtc aca agc aat gcc tac tct 162 Met Met Phe Ala Val His Cys Thr Trp Val Thr Ser Asn Ala Tyr Ser 10 15 20 agt cca agt gta gtc ctg gcc tca tac aat cat gat ggc acc agg aat 210 Ser Pro Ser Val Val Leu Ala Ser Tyr Asn His Asp Gly Thr Arg Asn 25 30 35 atc tta gat gat ttt aga gaa gct tac ttt tgg cta agg caa aat aca 258 Ile Leu Asp Asp Phe Arg Glu Ala Tyr Phe Trp Leu Arg Gln Asn Thr 40 45 50 55 gat gaa cat gca cga gta atg tct tgg tgg gat tat ggc tat cag ata 306 Asp Glu His Ala Arg Val Met Ser Trp Trp Asp Tyr Gly Tyr Gln Ile 60 65 70 gct gga atg gct aat aga act acg ttg gtg gat aat aac acc tgg aat 354 Ala Gly Met Ala Asn Arg Thr Thr Leu Val Asp Asn Asn Thr Trp Asn 75 80 85 aac agc cac ata gca ctg gtg gga aaa gct atg tct tct aat gaa aca 402 Asn Ser His Ile Ala Leu Val Gly Lys Ala Met Ser Ser Asn Glu Thr 90 95 100 gca gcc tat aaa atc atg agg act cta gat gta gat tat gtt ttg gtt 450 Ala Ala Tyr Lys Ile Met Arg Thr Leu Asp Val Asp Tyr Val Leu Val 105 110 115 att ttt gga ggg gtt att ggc tat tct ggt gat gat atc aac aaa ttt 498 Ile Phe Gly Gly Val Ile Gly Tyr Ser Gly Asp Asp Ile Asn Lys Phe 120 125 130 135 ctc tgg atg gtt agg ata gct gaa gga gaa cat ccc aaa gac att cgg 546 Leu Trp Met Val Arg Ile Ala Glu Gly Glu His Pro Lys Asp Ile Arg 140 145 150 gaa agt gac tat ttt acc cca cag gga gaa ttc cgt gta gac aaa gca 594 Glu Ser Asp Tyr Phe Thr Pro Gln Gly Glu Phe Arg Val Asp Lys Ala 155 160 165 gga tcc cct act ttg ttg aat tgc ctt atg tat aaa atg tca tac tac 642 Gly Ser Pro Thr Leu Leu Asn Cys Leu Met Tyr Lys Met Ser Tyr Tyr 170 175 180 aga ttt gga gaa atg cag ctg gat ttt cgt aca ccc cca ggt ttt gac 690 Arg Phe Gly Glu Met Gln Leu Asp Phe Arg Thr Pro Pro Gly Phe Asp 185 190 195 cga aca cgt aat gct gag att gga aat aag gac att aaa ttc aaa cat 738 Arg Thr Arg Asn Ala Glu Ile Gly Asn Lys Asp Ile Lys Phe Lys His 200 205 210 215 ttg gaa gaa gcc ttt aca tca gaa cac tgg ctt gtt agg ata tat aaa 786 Leu Glu Glu Ala Phe Thr Ser Glu His Trp Leu Val Arg Ile Tyr Lys 220 225 230 gta aaa gca cct gat aac agg gag aca tta gat cac aaa cct cga gtc 834 Val Lys Ala Pro Asp Asn Arg Glu Thr Leu Asp His Lys Pro Arg Val 235 240 245 acc aac att ttc cca aaa cag aag tat ttg tca aag aag act acc aaa 882 Thr Asn Ile Phe Pro Lys Gln Lys Tyr Leu Ser Lys Lys Thr Thr Lys 250 255 260 agg aag cgt ggc tac att aaa aat aag ctg gtt ttt aag aaa ggc aag 930 Arg Lys Arg Gly Tyr Ile Lys Asn Lys Leu Val Phe Lys Lys Gly Lys 265 270 275 aaa ata tct aag aag act gtt taaatgcact gttctggttc ctaacttgaa 981 Lys Ile Ser Lys Lys Thr Val 280 285 gcagttgtcc ttgtgagaac cggtctttgc ctttagctca tgtcgtgttt cacagcaaag 1041 agggtacaga accatcactg gtccaggtta atgtacaaaa ttttctggca atgcctgatt 1101 aaaaaaataa aattggcttg ttgagaacag ctgttttcga tttctaatgt gaagcaagac 1161 agagcactgc tgtaaatgtc tagcagcaga tttttttttt attggtacat attatccttc 1221 aaatctgaga atttggacta actgcaccaa agaaccctct aatttggtcc ctggcacatg 1281 catacttgtc aatgttttta ttcttttaca agacctgcat tttatttgaa ttacccgaat 1341 agcaatatgt aaaatacaag tgacaaaatg tgatgagagc ttcttgaacc ggtaaactag 1401 tacaggtctg agaaagacat attagaagaa tcattatact tccttgaatt atatttattt 1461 tcatgtttct ctaatgcaaa gaatgtttca tcaaatgtat attttctgtt gcttactgtt 1521 tgctctggga agaagctgct gtttcaaaga tggacctctg agtagctaat tgattcaagt 1581 agttttttta tgttgacaca ttattactgc tgttagcagt cgttttcacc aggtacttac 1641 agagcagatt tcatacatca ttcattcaag ggctaaattt atattttttg gaaatcatgg 1701 caactacaca ggatgttgct taccaggacg gagttttggt atcttagtac tgaagttagc 1761 actatgttta catgcaaaag attaaggaaa aaacccttaa agtggacagg tatccaaagt 1821 tcattttctg tgactcatca aagtgacaaa agacttgtaa caactttgcc tggacttttt 1881 tcattttaca acagttcatc cattcacaat gattttgttc tctgctccat attttttaat 1941 cccttaagca tttgatgaaa cactctttag tgctatatgc attttcttac ttttgttaaa 2001 aatgtgacaa ttgtcaaaaa atgcactaaa atgtaaatgg agattgaaca agttcacttt 2061 ccagcttata ggcaacttta tacagacttg aacattttct ccagttgttt agtaaaagtg 2121 aaagagaaag ggtttttcct gccacaggat ataacttttt tttatataac aagcataaca 2181 caccactgct tttggtggaa aagtgcagaa tagtatgtac cttttatgaa gaaaaatgta 2241 atttacaata ttcagtgaga atgttactgc tgattttctt ttccaaggtg tagaatattc 2301 tttgatttat agaattcatt tttgacccag atgatggttc ctttacagaa caataaaatg 2361 gctgaacatt ttcacaaata gagtgtaacg aagtctggat ttctgatacc ttgtcatttg 2421 ggggatttta ttttactttg ttgctttaaa attcaatgca gagaagttgt tgactgtagg 2481 ggaaataaag ttaattcaaa ttttgtgtt 2510 <210> 58 <211> 286 <212> PRT <213> Homo sapiens <400> 58 Met Leu Met Leu Met Leu Leu Met Met Phe Ala Val His Cys Thr Trp 1 5 10 15 Val Thr Ser Asn Ala Tyr Ser Ser Pro Ser Val Val Leu Ala Ser Tyr 20 25 30 Asn His Asp Gly Thr Arg Asn Ile Leu Asp Asp Phe Arg Glu Ala Tyr 35 40 45 Phe Trp Leu Arg Gln Asn Thr Asp Glu His Ala Arg Val Met Ser Trp 50 55 60 Trp Asp Tyr Gly Tyr Gln Ile Ala Gly Met Ala Asn Arg Thr Thr Leu 65 70 75 80 Val Asp Asn Asn Thr Trp Asn Asn Ser His Ile Ala Leu Val Gly Lys 85 90 95 Ala Met Ser Ser Asn Glu Thr Ala Ala Tyr Lys Ile Met Arg Thr Leu 100 105 110 Asp Val Asp Tyr Val Leu Val Ile Phe Gly Gly Val Ile Gly Tyr Ser 115 120 125 Gly Asp Asp Ile Asn Lys Phe Leu Trp Met Val Arg Ile Ala Glu Gly 130 135 140 Glu His Pro Lys Asp Ile Arg Glu Ser Asp Tyr Phe Thr Pro Gln Gly 145 150 155 160 Glu Phe Arg Val Asp Lys Ala Gly Ser Pro Thr Leu Leu Asn Cys Leu 165 170 175 Met Tyr Lys Met Ser Tyr Tyr Arg Phe Gly Glu Met Gln Leu Asp Phe 180 185 190 Arg Thr Pro Pro Gly Phe Asp Arg Thr Arg Asn Ala Glu Ile Gly Asn 195 200 205 Lys Asp Ile Lys Phe Lys His Leu Glu Glu Ala Phe Thr Ser Glu His 210 215 220 Trp Leu Val Arg Ile Tyr Lys Val Lys Ala Pro Asp Asn Arg Glu Thr 225 230 235 240 Leu Asp His Lys Pro Arg Val Thr Asn Ile Phe Pro Lys Gln Lys Tyr 245 250 255 Leu Ser Lys Lys Thr Thr Lys Arg Lys Arg Gly Tyr Ile Lys Asn Lys 260 265 270 Leu Val Phe Lys Lys Gly Lys Lys Ile Ser Lys Lys Thr Val 275 280 285 <210> 59 <211> 3558 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (80)..(2704) <400> 59 gtcccgcagt ggctggagcc ctgggcgctg caaagcgtgt cccgccgggt ccccgagcgt 60 cccgcgccct cgccccgcc atg ctc ctg ctg ctg ggg ctg tgc ctg ggg ctg 112 Met Leu Leu Leu Leu Gly Leu Cys Leu Gly Leu 1 5 10 tcc ctg tgt gtg ggg tcg cag gaa gag gcg cag agc tgg ggc cac tct 160 Ser Leu Cys Val Gly Ser Gln Glu Glu Ala Gln Ser Trp Gly His Ser 15 20 25 tcg gag cag gat gga ctc agg gtc ccg agg caa gtc aga ctg ttg cag 208 Ser Glu Gln Asp Gly Leu Arg Val Pro Arg Gln Val Arg Leu Leu Gln 30 35 40 agg ctg aaa acc aaa cct ttg atg aca gaa ttc tca gtg aag tct acc 256 Arg Leu Lys Thr Lys Pro Leu Met Thr Glu Phe Ser Val Lys Ser Thr 45 50 55 atc att tcc cgt tat gcc ttc act acg gtt ccc tgc aga atg ctg aac 304 Ile Ile Ser Arg Tyr Ala Phe Thr Thr Val Pro Cys Arg Met Leu Asn 60 65 70 75 aga gct tct gaa gac cag gac att gag ttc cag atg cag att cca gct 352 Arg Ala Ser Glu Asp Gln Asp Ile Glu Phe Gln Met Gln Ile Pro Ala 80 85 90 gca gct ttc atc acc aac ttc act atg ctt att gga gac aag gtg tat 400 Ala Ala Phe Ile Thr Asn Phe Thr Met Leu Ile Gly Asp Lys Val Tyr 95 100 105 cag ggc gaa att aca gag aga gaa aag aag agt ggt gat agg gta aaa 448 Gln Gly Glu Ile Thr Glu Arg Glu Lys Lys Ser Gly Asp Arg Val Lys 110 115 120 gag aaa agg aat aaa acc aca gaa gaa aat gga gag aag ggg act gaa 496 Glu Lys Arg Asn Lys Thr Thr Glu Glu Asn Gly Glu Lys Gly Thr Glu 125 130 135 ata ttc aga gct tct gca gtg att ccc agc aag gac aaa gcc gcc ttt 544 Ile Phe Arg Ala Ser Ala Val Ile Pro Ser Lys Asp Lys Ala Ala Phe 140 145 150 155 ttc ctg agt tat gag gag ctt ctg cag agg cgc ctg ggc aag tac gag 592 Phe Leu Ser Tyr Glu Glu Leu Leu Gln Arg Arg Leu Gly Lys Tyr Glu 160 165 170 cac agc atc agc gtg cgg ccc cag cag ctg tcc ggg agg ctg agc gtg 640 His Ser Ile Ser Val Arg Pro Gln Gln Leu Ser Gly Arg Leu Ser Val 175 180 185 gac gtg aat atc ctg gag agc gcg ggc atc gca tcc ctg gag gtg ctg 688 Asp Val Asn Ile Leu Glu Ser Ala Gly Ile Ala Ser Leu Glu Val Leu 190 195 200 ccg ctt cac aac agc agg cag agg ggc agt ggg cgc ggg gaa gat gat 736 Pro Leu His Asn Ser Arg Gln Arg Gly Ser Gly Arg Gly Glu Asp Asp 205 210 215 tct ggg cct ccc cca tct act gtc att aac caa aat gaa aca ttt gcc 784 Ser Gly Pro Pro Pro Ser Thr Val Ile Asn Gln Asn Glu Thr Phe Ala 220 225 230 235 aac ata att ttt aaa cct act gta gta caa caa gcc agg att gcc cag 832 Asn Ile Ile Phe Lys Pro Thr Val Val Gln Gln Ala Arg Ile Ala Gln 240 245 250 aat gga ttt ttg gga gac ttt atc att aga tat gac gtc aat aga gaa 880 Asn Gly Phe Leu Gly Asp Phe Ile Ile Arg Tyr Asp Val Asn Arg Glu 255 260 265 cag agc att ggg gac atc cag gtt cta aat ggc tat ttt gtg cac tac 928 Gln Ser Ile Gly Asp Ile Gln Val Leu Asn Gly Tyr Phe Val His Tyr 270 275 280 ttt gct cct aaa gac ctt cct cct tta ccc aag aat gtg gta ttc gtg 976 Phe Ala Pro Lys Asp Leu Pro Pro Leu Pro Lys Asn Val Val Phe Val 285 290 295 ctt gac agc agt gct cct atg gtg gga acc aaa ctc cgg cag acc aag 1024 Leu Asp Ser Ser Ala Pro Met Val Gly Thr Lys Leu Arg Gln Thr Lys 300 305 310 315 gat gcc ctc ttc aca att ctc cat gac ctc cga ccc cag gac cgt ttc 1072 Asp Ala Leu Phe Thr Ile Leu His Asp Leu Arg Pro Gln Asp Arg Phe 320 325 330 agt atc att gga ttt tcc aac cgg atc aaa gta tgg aag gac cac ttg 1120 Ser Ile Ile Gly Phe Ser Asn Arg Ile Lys Val Trp Lys Asp His Leu 335 340 345 ata tca gtc act cca gac agc atc agg gat ggg aat gtg tac att cac 1168 Ile Ser Val Thr Pro Asp Ser Ile Arg Asp Gly Asn Val Tyr Ile His 350 355 360 cat atg tca ccc act gga ggc aca gac atc aac ggg gcc ctg cag agg 1216 His Met Ser Pro Thr Gly Gly Thr Asp Ile Asn Gly Ala Leu Gln Arg 365 370 375 gcc atc agg ctc ctc aac aag tac gtg gcc cac agt ggc att gga gac 1264 Ala Ile Arg Leu Leu Asn Lys Tyr Val Ala His Ser Gly Ile Gly Asp 380 385 390 395 cgg agc gtg tcc ctc atc gtc ttc ctg acg gat ggg aag ccc acg gtc 1312 Arg Ser Val Ser Leu Ile Val Phe Leu Thr Asp Gly Lys Pro Thr Val 400 405 410 ggg gag acg cac acc ctc aag atc ctc aac aac acc cga gag gcc gcc 1360 Gly Glu Thr His Thr Leu Lys Ile Leu Asn Asn Thr Arg Glu Ala Ala 415 420 425 cga ggc caa gtc tgc atc ttc acc att ggc atc ggc aac gac gtg gac 1408 Arg Gly Gln Val Cys Ile Phe Thr Ile Gly Ile Gly Asn Asp Val Asp 430 435 440 ttc agg ctg ctg gag aaa ctg tcg ctg gag aac tgt ggc ctc aca cgg 1456 Phe Arg Leu Leu Glu Lys Leu Ser Leu Glu Asn Cys Gly Leu Thr Arg 445 450 455 cgc gtg cac gag gag gag gac gca ggc tcg cag ctc atc ggg ttc tac 1504 Arg Val His Glu Glu Glu Asp Ala Gly Ser Gln Leu Ile Gly Phe Tyr 460 465 470 475 gat gaa atc agg acc ccg ctc ctc tct gac atc cgc atc gat tat ccc 1552 Asp Glu Ile Arg Thr Pro Leu Leu Ser Asp Ile Arg Ile Asp Tyr Pro 480 485 490 ccc agc tca gtg gtg cag gcc acc aag acc ctg ttc ccc aac tac ttc 1600 Pro Ser Ser Val Val Gln Ala Thr Lys Thr Leu Phe Pro Asn Tyr Phe 495 500 505 aac ggc tcg gag atc atc att gcg ggg aag ctg gtg gac agg aag ctg 1648 Asn Gly Ser Glu Ile Ile Ile Ala Gly Lys Leu Val Asp Arg Lys Leu 510 515 520 gat cac ctg cac gtg gag gtc acc gcc agc aac agt aag aaa ttc atc 1696 Asp His Leu His Val Glu Val Thr Ala Ser Asn Ser Lys Lys Phe Ile 525 530 535 atc ctg aag aca gat gtg cct gtg cgg cct cag aag gca ggg aaa gat 1744 Ile Leu Lys Thr Asp Val Pro Val Arg Pro Gln Lys Ala Gly Lys Asp 540 545 550 555 gtc aca gga agc ccc agg cct gga ggc gat gga gag ggg gac ccc aac 1792 Val Thr Gly Ser Pro Arg Pro Gly Gly Asp Gly Glu Gly Asp Pro Asn 560 565 570 cac atc gag cgt ctc tgg agc tac ctc acc aca aag gag ctg ctg agc 1840 His Ile Glu Arg Leu Trp Ser Tyr Leu Thr Thr Lys Glu Leu Leu Ser 575 580 585 tcc tgg ctg caa agt gac gat gaa ccg gag aag gag cgg ctg cgg cag 1888 Ser Trp Leu Gln Ser Asp Asp Glu Pro Glu Lys Glu Arg Leu Arg Gln 590 595 600 cgg gcc cag gcc ctg gct gtg agc tac cgc ttc ctc act ccc ttc acc 1936 Arg Ala Gln Ala Leu Ala Val Ser Tyr Arg Phe Leu Thr Pro Phe Thr 605 610 615 tcc atg aag ctg agg ggg ccg gtc cca cgc atg gac ggc ctg gag gag 1984 Ser Met Lys Leu Arg Gly Pro Val Pro Arg Met Asp Gly Leu Glu Glu 620 625 630 635 gcc cac ggc atg tcg gct gcc atg gga ccc gaa ccg gtg gtg cag agc 2032 Ala His Gly Met Ser Ala Ala Met Gly Pro Glu Pro Val Val Gln Ser 640 645 650 gtg cga gga gct ggc acg cag cca gga cct ttg ctc aag aag cca tac 2080 Val Arg Gly Ala Gly Thr Gln Pro Gly Pro Leu Leu Lys Lys Pro Tyr 655 660 665 cag cca aga att aaa atc tct aaa aca tca gtg gat ggt gat ccc cac 2128 Gln Pro Arg Ile Lys Ile Ser Lys Thr Ser Val Asp Gly Asp Pro His 670 675 680 ttt gtt gtg gat ttc ccc ctg agc aga ctc acc gtg tgc ttc aac att 2176 Phe Val Val Asp Phe Pro Leu Ser Arg Leu Thr Val Cys Phe Asn Ile 685 690 695 gat ggg cag ccc ggg gac atc ctc agg ctg gtc tct gat cac agg gac 2224 Asp Gly Gln Pro Gly Asp Ile Leu Arg Leu Val Ser Asp His Arg Asp 700 705 710 715 tct ggt gtc aca gtg aac gga gag tta att ggg gca ccc gcc cct cca 2272 Ser Gly Val Thr Val Asn Gly Glu Leu Ile Gly Ala Pro Ala Pro Pro 720 725 730 aat ggc cac aag aaa cag cgc act tac ttg cgc act atc acc atc ctc 2320 Asn Gly His Lys Lys Gln Arg Thr Tyr Leu Arg Thr Ile Thr Ile Leu 735 740 745 atc aac aag cca gag aga tct tat ctc gag atc aca ccg agc aga gtc 2368 Ile Asn Lys Pro Glu Arg Ser Tyr Leu Glu Ile Thr Pro Ser Arg Val 750 755 760 atc ttg gat ggt ggg gac aga ctg gtg ctc ccc tgc aac cag agt gtg 2416 Ile Leu Asp Gly Gly Asp Arg Leu Val Leu Pro Cys Asn Gln Ser Val 765 770 775 gtg gtg ggg agc tgg ggg ctg gag gtg tcc gtg tct gcc aac gcc aat 2464 Val Val Gly Ser Trp Gly Leu Glu Val Ser Val Ser Ala Asn Ala Asn 780 785 790 795 gtc acc gtc acc atc cag ggc tcc ata gcc ttt gtc atc ctc atc cac 2512 Val Thr Val Thr Ile Gln Gly Ser Ile Ala Phe Val Ile Leu Ile His 800 805 810 ctc tac aaa aag ccg ggc gcc ctt cca gcg aca cca cct ggg ttt cta 2560 Leu Tyr Lys Lys Pro Gly Ala Leu Pro Ala Thr Pro Pro Gly Phe Leu 815 820 825 cat tgc caa cag cga ggg cct ttc cag caa ctg cca cgg act gct ggg 2608 His Cys Gln Gln Arg Gly Pro Phe Gln Gln Leu Pro Arg Thr Ala Gly 830 835 840 tca gtt cct gaa tca gga tgc cag act cac aga aga ccc tgc agg gcc 2656 Ser Val Pro Glu Ser Gly Cys Gln Thr His Arg Arg Pro Cys Arg Ala 845 850 855 cag cca gaa cct cac tca ccc tct gct cct tca ggt ggg aga ggg gcc 2704 Gln Pro Glu Pro His Ser Pro Ser Ala Pro Ser Gly Gly Arg Gly Ala 860 865 870 875 tgaggccgtc ctaacagtga aaggccacca agtcccagtg gtctggaagc aaaggaagat 2764 ttacaacggg gaagagcaga tagactgctg gtttgccagg aacaatgccg ccaaactgat 2824 tgacggggag tacaaggatt acctggcatc ccatccattt gacacaggga tgacacttgg 2884 ccggggaatg tccagggagc tctgaagctg gcagccttaa agatgcaagt gcatgaagga 2944 cagtgatgtg gggaggccgt ggggcagctc ttttcatggc ttgtacacgc ctcagctcct 3004 ggcaattagc tggactccat gacccacccc tggtgcagca tagatccgac gtctgtctgg 3064 gcgaagggta ggggtgggta ggggcgggaa gcctgagtgc aaatgtcatt tccctctact 3124 gcctcttcct gcctctcccc accctgccca catccacaga ggggagagaa gggtcatagc 3184 taaatgcaac aaactctgta tcttgtccca acctgctttt ctgttctgtt agcatatcat 3244 aaagtaagcc tttctggtga aggaaggttg ctatgaaact ttttttcttg gtggaaatgg 3304 ccaagtttag gcactctgct ttttgcctta cactaatgct tagaaagctg tcttttcagt 3364 ggtgttgcac cccccagatg tgtggccaac ctctgctgca aaggaatctc ttgctgagtc 3424 caggccacca atcaggcaaa tagcccatac atttgatcgt tgtaaaccat gaagtctttt 3484 cttgcaagac gtttttcttc tgctgtggta tcttgccctt aaaaattagt tttcattaaa 3544 aagaaatttg attg 3558 <210> 60 <211> 875 <212> PRT <213> Homo sapiens <400> 60 Met Leu Leu Leu Leu Gly Leu Cys Leu Gly Leu Ser Leu Cys Val Gly 1 5 10 15 Ser Gln Glu Glu Ala Gln Ser Trp Gly His Ser Ser Glu Gln Asp Gly 20 25 30 Leu Arg Val Pro Arg Gln Val Arg Leu Leu Gln Arg Leu Lys Thr Lys 35 40 45 Pro Leu Met Thr Glu Phe Ser Val Lys Ser Thr Ile Ile Ser Arg Tyr 50 55 60 Ala Phe Thr Thr Val Pro Cys Arg Met Leu Asn Arg Ala Ser Glu Asp 65 70 75 80 Gln Asp Ile Glu Phe Gln Met Gln Ile Pro Ala Ala Ala Phe Ile Thr 85 90 95 Asn Phe Thr Met Leu Ile Gly Asp Lys Val Tyr Gln Gly Glu Ile Thr 100 105 110 Glu Arg Glu Lys Lys Ser Gly Asp Arg Val Lys Glu Lys Arg Asn Lys 115 120 125 Thr Thr Glu Glu Asn Gly Glu Lys Gly Thr Glu Ile Phe Arg Ala Ser 130 135 140 Ala Val Ile Pro Ser Lys Asp Lys Ala Ala Phe Phe Leu Ser Tyr Glu 145 150 155 160 Glu Leu Leu Gln Arg Arg Leu Gly Lys Tyr Glu His Ser Ile Ser Val 165 170 175 Arg Pro Gln Gln Leu Ser Gly Arg Leu Ser Val Asp Val Asn Ile Leu 180 185 190 Glu Ser Ala Gly Ile Ala Ser Leu Glu Val Leu Pro Leu His Asn Ser 195 200 205 Arg Gln Arg Gly Ser Gly Arg Gly Glu Asp Asp Ser Gly Pro Pro Pro 210 215 220 Ser Thr Val Ile Asn Gln Asn Glu Thr Phe Ala Asn Ile Ile Phe Lys 225 230 235 240 Pro Thr Val Val Gln Gln Ala Arg Ile Ala Gln Asn Gly Phe Leu Gly 245 250 255 Asp Phe Ile Ile Arg Tyr Asp Val Asn Arg Glu Gln Ser Ile Gly Asp 260 265 270 Ile Gln Val Leu Asn Gly Tyr Phe Val His Tyr Phe Ala Pro Lys Asp 275 280 285 Leu Pro Pro Leu Pro Lys Asn Val Val Phe Val Leu Asp Ser Ser Ala 290 295 300 Pro Met Val Gly Thr Lys Leu Arg Gln Thr Lys Asp Ala Leu Phe Thr 305 310 315 320 Ile Leu His Asp Leu Arg Pro Gln Asp Arg Phe Ser Ile Ile Gly Phe 325 330 335 Ser Asn Arg Ile Lys Val Trp Lys Asp His Leu Ile Ser Val Thr Pro 340 345 350 Asp Ser Ile Arg Asp Gly Asn Val Tyr Ile His His Met Ser Pro Thr 355 360 365 Gly Gly Thr Asp Ile Asn Gly Ala Leu Gln Arg Ala Ile Arg Leu Leu 370 375 380 Asn Lys Tyr Val Ala His Ser Gly Ile Gly Asp Arg Ser Val Ser Leu 385 390 395 400 Ile Val Phe Leu Thr Asp Gly Lys Pro Thr Val Gly Glu Thr His Thr 405 410 415 Leu Lys Ile Leu Asn Asn Thr Arg Glu Ala Ala Arg Gly Gln Val Cys 420 425 430 Ile Phe Thr Ile Gly Ile Gly Asn Asp Val Asp Phe Arg Leu Leu Glu 435 440 445 Lys Leu Ser Leu Glu Asn Cys Gly Leu Thr Arg Arg Val His Glu Glu 450 455 460 Glu Asp Ala Gly Ser Gln Leu Ile Gly Phe Tyr Asp Glu Ile Arg Thr 465 470 475 480 Pro Leu Leu Ser Asp Ile Arg Ile Asp Tyr Pro Pro Ser Ser Val Val 485 490 495 Gln Ala Thr Lys Thr Leu Phe Pro Asn Tyr Phe Asn Gly Ser Glu Ile 500 505 510 Ile Ile Ala Gly Lys Leu Val Asp Arg Lys Leu Asp His Leu His Val 515 520 525 Glu Val Thr Ala Ser Asn Ser Lys Lys Phe Ile Ile Leu Lys Thr Asp 530 535 540 Val Pro Val Arg Pro Gln Lys Ala Gly Lys Asp Val Thr Gly Ser Pro 545 550 555 560 Arg Pro Gly Gly Asp Gly Glu Gly Asp Pro Asn His Ile Glu Arg Leu 565 570 575 Trp Ser Tyr Leu Thr Thr Lys Glu Leu Leu Ser Ser Trp Leu Gln Ser 580 585 590 Asp Asp Glu Pro Glu Lys Glu Arg Leu Arg Gln Arg Ala Gln Ala Leu 595 600 605 Ala Val Ser Tyr Arg Phe Leu Thr Pro Phe Thr Ser Met Lys Leu Arg 610 615 620 Gly Pro Val Pro Arg Met Asp Gly Leu Glu Glu Ala His Gly Met Ser 625 630 635 640 Ala Ala Met Gly Pro Glu Pro Val Val Gln Ser Val Arg Gly Ala Gly 645 650 655 Thr Gln Pro Gly Pro Leu Leu Lys Lys Pro Tyr Gln Pro Arg Ile Lys 660 665 670 Ile Ser Lys Thr Ser Val Asp Gly Asp Pro His Phe Val Val Asp Phe 675 680 685 Pro Leu Ser Arg Leu Thr Val Cys Phe Asn Ile Asp Gly Gln Pro Gly 690 695 700 Asp Ile Leu Arg Leu Val Ser Asp His Arg Asp Ser Gly Val Thr Val 705 710 715 720 Asn Gly Glu Leu Ile Gly Ala Pro Ala Pro Pro Asn Gly His Lys Lys 725 730 735 Gln Arg Thr Tyr Leu Arg Thr Ile Thr Ile Leu Ile Asn Lys Pro Glu 740 745 750 Arg Ser Tyr Leu Glu Ile Thr Pro Ser Arg Val Ile Leu Asp Gly Gly 755 760 765 Asp Arg Leu Val Leu Pro Cys Asn Gln Ser Val Val Val Gly Ser Trp 770 775 780 Gly Leu Glu Val Ser Val Ser Ala Asn Ala Asn Val Thr Val Thr Ile 785 790 795 800 Gln Gly Ser Ile Ala Phe Val Ile Leu Ile His Leu Tyr Lys Lys Pro 805 810 815 Gly Ala Leu Pro Ala Thr Pro Pro Gly Phe Leu His Cys Gln Gln Arg 820 825 830 Gly Pro Phe Gln Gln Leu Pro Arg Thr Ala Gly Ser Val Pro Glu Ser 835 840 845 Gly Cys Gln Thr His Arg Arg Pro Cys Arg Ala Gln Pro Glu Pro His 850 855 860 Ser Pro Ser Ala Pro Ser Gly Gly Arg Gly Ala 865 870 875 <210> 61 <211> 2092 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (161)..(1210) <400> 61 gtgtggagaa agcggcagct gtcccagcgg aagcgacgaa gggacgggac ccgggagcct 60 ggacgagtcc gagcgcgtca cctcctcacg ctgcggctgt cgcccgtgtc ccgccggccc 120 gttccgtgtc gccccgcagt gctgcggccg ccgcggcacc atg gct gtg ttt gtc 175 Met Ala Val Phe Val 1 5 gtg ctc ctg gcg ttg gtg gcg ggt gtt ttg ggg aac gag ttt agt ata 223 Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly Asn Glu Phe Ser Ile 10 15 20 tta aaa tca cca ggg tct gtt gtt ttc cga aat gga aat tgg cct ata 271 Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn Gly Asn Trp Pro Ile 25 30 35 cca gga gag cgg atc cca gac gtg gct gca ttg tcc atg ggc ttc tct 319 Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu Ser Met Gly Phe Ser 40 45 50 gtg aaa gaa gac ctt tct tgg cca gga ctc gca gtg ggt aac ctg ttt 367 Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala Val Gly Asn Leu Phe 55 60 65 cat cgt cct cgg gct acc gtc atg gtg atg gtg aag gga gtg aac aaa 415 His Arg Pro Arg Ala Thr Val Met Val Met Val Lys Gly Val Asn Lys 70 75 80 85 ctg gct cta ccc cca ggc agt gtc att tcg tac cct ttg gag aat gca 463 Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr Pro Leu Glu Asn Ala 90 95 100 gtt cct ttt agt ctt gac agt gtt gca aat tcc att cac tcc tta ttt 511 Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser Ile His Ser Leu Phe 105 110 115 tct gag gaa act cct gtt gtt ttg cag ttg gct ccc agt gag gaa aga 559 Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala Pro Ser Glu Glu Arg 120 125 130 gtg tat atg gta ggg aag gca aac tca gtg ttt gaa gac ctt tca gtc 607 Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe Glu Asp Leu Ser Val 135 140 145 acc ttg cgc cag ctc cgt aat cgc ctg ttt caa gaa aac tct gtt ctc 655 Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln Glu Asn Ser Val Leu 150 155 160 165 agt tca ctc ccc ctc aat tct ctg agt agg aac aat gaa gtt gac ctg 703 Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn Asn Glu Val Asp Leu 170 175 180 ctc ttt ctt tct gaa ctg caa gtg cta cat gat att tca agc ttg ctg 751 Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp Ile Ser Ser Leu Leu 185 190 195 tct cgt cat aag cat cta gcc aag gat cat tct cct gat tta tat tca 799 Ser Arg His Lys His Leu Ala Lys Asp His Ser Pro Asp Leu Tyr Ser 200 205 210 ctg gag ctg gca ggt ttg gat gaa att ggg aag cgt tat ggg gaa gac 847 Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys Arg Tyr Gly Glu Asp 215 220 225 tct gaa caa ttc aga gat gct tct aag atc ctt gtt gac gct ctg caa 895 Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu Val Asp Ala Leu Gln 230 235 240 245 aag ttt gca gat gac atg tac agt ctt tat ggt ggg aaa gca gtg gta 943 Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly Gly Lys Ala Val Val 250 255 260 gag tta gtc act gtc aag tca ttt gac acc tcc ctc att agg aag aca 991 Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser Leu Ile Arg Lys Thr 265 270 275 agg act atc ctt gag gca aaa caa gcg aag aac cca gca agt ccc tat 1039 Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn Pro Ala Ser Pro Tyr 280 285 290 aac ctt gca tat aag tat aat ttt gaa tat tcc gtg gtt ttc aac atg 1087 Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser Val Val Phe Asn Met 295 300 305 gta ctt tgg ata atg atc gcc ttg gcc ttg gct gtg att atc acc tct 1135 Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala Val Ile Ile Thr Ser 310 315 320 325 tac aat att tgg aac atg gat cct gga tat gat agc atc att tat agg 1183 Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp Ser Ile Ile Tyr Arg 330 335 340 atg aca aac cag aag att cga atg gat tgaatgttac ctgtgccaga 1230 Met Thr Asn Gln Lys Ile Arg Met Asp 345 350 attagaaaag ggggttggaa attggctgtt ttgttaaaat atatctttta gtgtgcttta 1290 aagtagatag tatactttac atttataaaa aaaaatcaag ttttgttctt tattttgtgt 1350 gtgccggtga tgtttttcta gagtgaatta tagtattgac gtgaatccca ctgtggtata 1410 gattccataa tatgcttgaa tattatgata tagccattta ataacattga tttcattctg 1470 tttaatgaat ttggaaatat gcactgaaag aaatgtaaaa catttagaat agctcgtgtt 1530 atggaaaaaa gtgcactgaa tttattagac aaacttacga atgcttaact tctttacaca 1590 gcataggtga aaatcatatt tgggctattg tatactatga acaatttgta aatgtcttaa 1650 tttgatgtaa ataactctga aacaagagaa aaggttttta acttagagta gccctaaaat 1710 atggatgtgc ttatataatc gcttagtttt ggaactgtat ctgagtaaca gaggacaact 1770 gttttttaac cctcttctgc aagtttgttg acctacatgg gctaatatgg atactaaaaa 1830 tactacattg atctaagaag aaactagcct tgtggagtat atagatgctt ttcattatac 1890 acacaaaaat ccctgaggga cattttgagg catgaatata aaacattttt atttcagtaa 1950 cttttccccc tgtgtaagtt actatggttt gtggtacaac ttcattctat agaatattaa 2010 gtggaagtgg gtgaattcta ctttttatgt tggagtggac caatgtctat caagagtgac 2070 aaataaagtt aatgatgatt cc 2092 <210> 62 <211> 350 <212> PRT <213> Homo sapiens <400> 62 Met Ala Val Phe Val Val Leu Leu Ala Leu Val Ala Gly Val Leu Gly 1 5 10 15 Asn Glu Phe Ser Ile Leu Lys Ser Pro Gly Ser Val Val Phe Arg Asn 20 25 30 Gly Asn Trp Pro Ile Pro Gly Glu Arg Ile Pro Asp Val Ala Ala Leu 35 40 45 Ser Met Gly Phe Ser Val Lys Glu Asp Leu Ser Trp Pro Gly Leu Ala 50 55 60 Val Gly Asn Leu Phe His Arg Pro Arg Ala Thr Val Met Val Met Val 65 70 75 80 Lys Gly Val Asn Lys Leu Ala Leu Pro Pro Gly Ser Val Ile Ser Tyr 85 90 95 Pro Leu Glu Asn Ala Val Pro Phe Ser Leu Asp Ser Val Ala Asn Ser 100 105 110 Ile His Ser Leu Phe Ser Glu Glu Thr Pro Val Val Leu Gln Leu Ala 115 120 125 Pro Ser Glu Glu Arg Val Tyr Met Val Gly Lys Ala Asn Ser Val Phe 130 135 140 Glu Asp Leu Ser Val Thr Leu Arg Gln Leu Arg Asn Arg Leu Phe Gln 145 150 155 160 Glu Asn Ser Val Leu Ser Ser Leu Pro Leu Asn Ser Leu Ser Arg Asn 165 170 175 Asn Glu Val Asp Leu Leu Phe Leu Ser Glu Leu Gln Val Leu His Asp 180 185 190 Ile Ser Ser Leu Leu Ser Arg His Lys His Leu Ala Lys Asp His Ser 195 200 205 Pro Asp Leu Tyr Ser Leu Glu Leu Ala Gly Leu Asp Glu Ile Gly Lys 210 215 220 Arg Tyr Gly Glu Asp Ser Glu Gln Phe Arg Asp Ala Ser Lys Ile Leu 225 230 235 240 Val Asp Ala Leu Gln Lys Phe Ala Asp Asp Met Tyr Ser Leu Tyr Gly 245 250 255 Gly Lys Ala Val Val Glu Leu Val Thr Val Lys Ser Phe Asp Thr Ser 260 265 270 Leu Ile Arg Lys Thr Arg Thr Ile Leu Glu Ala Lys Gln Ala Lys Asn 275 280 285 Pro Ala Ser Pro Tyr Asn Leu Ala Tyr Lys Tyr Asn Phe Glu Tyr Ser 290 295 300 Val Val Phe Asn Met Val Leu Trp Ile Met Ile Ala Leu Ala Leu Ala 305 310 315 320 Val Ile Ile Thr Ser Tyr Asn Ile Trp Asn Met Asp Pro Gly Tyr Asp 325 330 335 Ser Ile Ile Tyr Arg Met Thr Asn Gln Lys Ile Arg Met Asp 340 345 350 <210> 63 <211> 2341 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (94)..(1662) <400> 63 agtgcctttg gcgcactgag gtgcacaggg tcccttagcc gggcgcaggg cgcgcagccc 60 aggctgagat ccgcggcttc cgtagaagtg agc atg gct ggg cag cga gtg ctt 114 Met Ala Gly Gln Arg Val Leu 1 5 ctt cta gtg ggc ttc ctt ctc cct ggg gtc ctg ctc tca gag gct gcc 162 Leu Leu Val Gly Phe Leu Leu Pro Gly Val Leu Leu Ser Glu Ala Ala 10 15 20 aaa atc ctg aca ata tct aca gta ggt gga agc cat tat cta ctg atg 210 Lys Ile Leu Thr Ile Ser Thr Val Gly Gly Ser His Tyr Leu Leu Met 25 30 35 gac cgg gtt tct cag att ctt caa gat cac ggt cat aat gtc acc atg 258 Asp Arg Val Ser Gln Ile Leu Gln Asp His Gly His Asn Val Thr Met 40 45 50 55 ctt aac cac aaa aga ggt cct ttt atg cca gat ttt aaa aag gaa gaa 306 Leu Asn His Lys Arg Gly Pro Phe Met Pro Asp Phe Lys Lys Glu Glu 60 65 70 aaa tca tat caa gtt atc agt tgg ctt gca cct gaa gat cat caa aga 354 Lys Ser Tyr Gln Val Ile Ser Trp Leu Ala Pro Glu Asp His Gln Arg 75 80 85 gaa ttt aaa aag agt ttt gat ttc ttt ctg gaa gaa act tta ggt ggc 402 Glu Phe Lys Lys Ser Phe Asp Phe Phe Leu Glu Glu Thr Leu Gly Gly 90 95 100 aga gga aaa ttt gaa aac tta tta aat gtt cta gaa tac ttg gcg ttg 450 Arg Gly Lys Phe Glu Asn Leu Leu Asn Val Leu Glu Tyr Leu Ala Leu 105 110 115 cag tgc agt cat ttt tta aat aga aag gat atc atg gat tcc tta aag 498 Gln Cys Ser His Phe Leu Asn Arg Lys Asp Ile Met Asp Ser Leu Lys 120 125 130 135 aat gag aac ttc gac atg gtg ata gtt gaa act ttt gac tac tgt cct 546 Asn Glu Asn Phe Asp Met Val Ile Val Glu Thr Phe Asp Tyr Cys Pro 140 145 150 ttc ctg att gct gag aag ctt ggg aag cca ttt gtg gcc att ctt tcc 594 Phe Leu Ile Ala Glu Lys Leu Gly Lys Pro Phe Val Ala Ile Leu Ser 155 160 165 act tca ttc ggc tct ttg gaa ttt ggg cta cca atc ccc ttg tct tat 642 Thr Ser Phe Gly Ser Leu Glu Phe Gly Leu Pro Ile Pro Leu Ser Tyr 170 175 180 gtt cca gta ttc cgt tcc ttg ctg act gat cac atg gac ttc tgg ggc 690 Val Pro Val Phe Arg Ser Leu Leu Thr Asp His Met Asp Phe Trp Gly 185 190 195 cga gtg aag aat ttt ctg atg ttc ttt agt ttc tgc agg agg caa cag 738 Arg Val Lys Asn Phe Leu Met Phe Phe Ser Phe Cys Arg Arg Gln Gln 200 205 210 215 cac atg cag tct aca ttt gac aac acc atc aag gaa cat ttc aca gaa 786 His Met Gln Ser Thr Phe Asp Asn Thr Ile Lys Glu His Phe Thr Glu 220 225 230 ggc tct agg cca gtt ttg tct cat ctt cta ctg aaa gca gag ttg tgg 834 Gly Ser Arg Pro Val Leu Ser His Leu Leu Leu Lys Ala Glu Leu Trp 235 240 245 ttc att aac tct gac ttt gcc ttt gat ttt gct cga cct ctg ctt ccc 882 Phe Ile Asn Ser Asp Phe Ala Phe Asp Phe Ala Arg Pro Leu Leu Pro 250 255 260 aac act gtt tat gtt gga ggc ttg atg gaa aaa cct att aaa cca gta 930 Asn Thr Val Tyr Val Gly Gly Leu Met Glu Lys Pro Ile Lys Pro Val 265 270 275 cca caa gac ttg gag aac ttc att gcc aag ttt gag gac tct ggt ttt 978 Pro Gln Asp Leu Glu Asn Phe Ile Ala Lys Phe Glu Asp Ser Gly Phe 280 285 290 295 gtc ctt gtg acc ttg ggc tcc atg gtg aac acc tgt cag aat ccg gaa 1026 Val Leu Val Thr Leu Gly Ser Met Val Asn Thr Cys Gln Asn Pro Glu 300 305 310 atc ttc aag gag atg aac aat gcc ttt gct cac cta ccc caa ggg gtg 1074 Ile Phe Lys Glu Met Asn Asn Ala Phe Ala His Leu Pro Gln Gly Val 315 320 325 ata tgg aag tgt cag tgt tct cat tgg ccc aaa gat gtc cac ctg gct 1122 Ile Trp Lys Cys Gln Cys Ser His Trp Pro Lys Asp Val His Leu Ala 330 335 340 gca aat gtg aaa att gtg gac tgg ctt cct cag agt gac ctc ctg gct 1170 Ala Asn Val Lys Ile Val Asp Trp Leu Pro Gln Ser Asp Leu Leu Ala 345 350 355 cac cca agc atc cgt ctg ttt gtc acc cac ggc ggg cag aat agc ata 1218 His Pro Ser Ile Arg Leu Phe Val Thr His Gly Gly Gln Asn Ser Ile 360 365 370 375 atg gag gcc atc cag cat ggt gtg ccc atg gtg ggg atc cct ctc ttt 1266 Met Glu Ala Ile Gln His Gly Val Pro Met Val Gly Ile Pro Leu Phe 380 385 390 gga gac cag cct gaa aac atg gtc cga gta gaa gcc aaa aag ttt ggt 1314 Gly Asp Gln Pro Glu Asn Met Val Arg Val Glu Ala Lys Lys Phe Gly 395 400 405 gtt tct att cag tta aag aag ctc aag gca gag aca ttg gct ctt aag 1362 Val Ser Ile Gln Leu Lys Lys Leu Lys Ala Glu Thr Leu Ala Leu Lys 410 415 420 atg aaa caa atc atg gaa gac aag aga tac aag tcc gcg gca gtg gct 1410 Met Lys Gln Ile Met Glu Asp Lys Arg Tyr Lys Ser Ala Ala Val Ala 425 430 435 gcc agt gtc atc ctg cgc tcc cac ccg ctc agc ccc aca cag cgg ctg 1458 Ala Ser Val Ile Leu Arg Ser His Pro Leu Ser Pro Thr Gln Arg Leu 440 445 450 455 gtg ggc tgg att gac cac gtc ctc cag aca ggg ggc gcg acg cac ctc 1506 Val Gly Trp Ile Asp His Val Leu Gln Thr Gly Gly Ala Thr His Leu 460 465 470 aag ccc tat gtc ttt cag cag ccc tgg cat gag cag tac ctg ctc gac 1554 Lys Pro Tyr Val Phe Gln Gln Pro Trp His Glu Gln Tyr Leu Leu Asp 475 480 485 gtt ttt gtg ttt ctg ctg ggg ctc act ctg ggg act cta tgg ctt tgt 1602 Val Phe Val Phe Leu Leu Gly Leu Thr Leu Gly Thr Leu Trp Leu Cys 490 495 500 ggg aag ctg ctg ggc atg gct gtc tgg tgg ctg cgt ggg gcc aga aag 1650 Gly Lys Leu Leu Gly Met Ala Val Trp Trp Leu Arg Gly Ala Arg Lys 505 510 515 gtg aag gag aca taaggccagg tgcagccttg gcggggtctg tttggtgggc 1702 Val Lys Glu Thr 520 gatgtcacca tttctaggga gcttcccact agttctggca gccccattct ctagtccttc 1762 tagttatctc ctgttttctt gaagaacagg aaaaatggcc aaaaatcatc ctttccactt 1822 gctaattttg ctacaaattc atccttacta gctcctgcct gctagcagaa ttctttccag 1882 tcctcttgtc ctcctttgtt tgccatcagc aagggctatg ctgtgattct gtctctgagt 1942 gacttggacc actgaccctc agatttccag ccttaaaatc caccttcctt ctcatgcgcc 2002 tctccgaatc acaccctgac tcttccagcc tccatgtcca gacctagtca gcctctctca 2062 ctcctgcccc tactatctat catggaataa catccaagaa agacaccttg catattcttt 2122 cagtttctgt tttgttctcc cacatattct cttcaatgct caggaagcct gccctgtgct 2182 tgagagttca gggccggaca caggctcaca ggtctccaca ttgggtccct gtctctggtg 2242 cccacagtga gctccttctt ggctgagcag gcatggagac tgtaggtttc cagatttcct 2302 gaaaaataaa agtttacagc gttatctctc cccaacctc 2341 <210> 64 <211> 523 <212> PRT <213> Homo sapiens <400> 64 Met Ala Gly Gln Arg Val Leu Leu Leu Val Gly Phe Leu Leu Pro Gly 1 5 10 15 Val Leu Leu Ser Glu Ala Ala Lys Ile Leu Thr Ile Ser Thr Val Gly 20 25 30 Gly Ser His Tyr Leu Leu Met Asp Arg Val Ser Gln Ile Leu Gln Asp 35 40 45 His Gly His Asn Val Thr Met Leu Asn His Lys Arg Gly Pro Phe Met 50 55 60 Pro Asp Phe Lys Lys Glu Glu Lys Ser Tyr Gln Val Ile Ser Trp Leu 65 70 75 80 Ala Pro Glu Asp His Gln Arg Glu Phe Lys Lys Ser Phe Asp Phe Phe 85 90 95 Leu Glu Glu Thr Leu Gly Gly Arg Gly Lys Phe Glu Asn Leu Leu Asn 100 105 110 Val Leu Glu Tyr Leu Ala Leu Gln Cys Ser His Phe Leu Asn Arg Lys 115 120 125 Asp Ile Met Asp Ser Leu Lys Asn Glu Asn Phe Asp Met Val Ile Val 130 135 140 Glu Thr Phe Asp Tyr Cys Pro Phe Leu Ile Ala Glu Lys Leu Gly Lys 145 150 155 160 Pro Phe Val Ala Ile Leu Ser Thr Ser Phe Gly Ser Leu Glu Phe Gly 165 170 175 Leu Pro Ile Pro Leu Ser Tyr Val Pro Val Phe Arg Ser Leu Leu Thr 180 185 190 Asp His Met Asp Phe Trp Gly Arg Val Lys Asn Phe Leu Met Phe Phe 195 200 205 Ser Phe Cys Arg Arg Gln Gln His Met Gln Ser Thr Phe Asp Asn Thr 210 215 220 Ile Lys Glu His Phe Thr Glu Gly Ser Arg Pro Val Leu Ser His Leu 225 230 235 240 Leu Leu Lys Ala Glu Leu Trp Phe Ile Asn Ser Asp Phe Ala Phe Asp 245 250 255 Phe Ala Arg Pro Leu Leu Pro Asn Thr Val Tyr Val Gly Gly Leu Met 260 265 270 Glu Lys Pro Ile Lys Pro Val Pro Gln Asp Leu Glu Asn Phe Ile Ala 275 280 285 Lys Phe Glu Asp Ser Gly Phe Val Leu Val Thr Leu Gly Ser Met Val 290 295 300 Asn Thr Cys Gln Asn Pro Glu Ile Phe Lys Glu Met Asn Asn Ala Phe 305 310 315 320 Ala His Leu Pro Gln Gly Val Ile Trp Lys Cys Gln Cys Ser His Trp 325 330 335 Pro Lys Asp Val His Leu Ala Ala Asn Val Lys Ile Val Asp Trp Leu 340 345 350 Pro Gln Ser Asp Leu Leu Ala His Pro Ser Ile Arg Leu Phe Val Thr 355 360 365 His Gly Gly Gln Asn Ser Ile Met Glu Ala Ile Gln His Gly Val Pro 370 375 380 Met Val Gly Ile Pro Leu Phe Gly Asp Gln Pro Glu Asn Met Val Arg 385 390 395 400 Val Glu Ala Lys Lys Phe Gly Val Ser Ile Gln Leu Lys Lys Leu Lys 405 410 415 Ala Glu Thr Leu Ala Leu Lys Met Lys Gln Ile Met Glu Asp Lys Arg 420 425 430 Tyr Lys Ser Ala Ala Val Ala Ala Ser Val Ile Leu Arg Ser His Pro 435 440 445 Leu Ser Pro Thr Gln Arg Leu Val Gly Trp Ile Asp His Val Leu Gln 450 455 460 Thr Gly Gly Ala Thr His Leu Lys Pro Tyr Val Phe Gln Gln Pro Trp 465 470 475 480 His Glu Gln Tyr Leu Leu Asp Val Phe Val Phe Leu Leu Gly Leu Thr 485 490 495 Leu Gly Thr Leu Trp Leu Cys Gly Lys Leu Leu Gly Met Ala Val Trp 500 505 510 Trp Leu Arg Gly Ala Arg Lys Val Lys Glu Thr 515 520 <210> 65 <211> 2971 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (103)..(2412) <400> 65 cgaccgagcc gagaggaccc gagtggggcc gaggccagta gccccggggc cctgagcaga 60 ggccgtagct tgcgccgcac ccgcggccag gcggagccaa ag atg ccg gcc tct 114 Met Pro Ala Ser 1 gct gcg cgg ccc cgc ccg ggt ccc ggg cag cct aca gcc tcg ccc ttc 162 Ala Ala Arg Pro Arg Pro Gly Pro Gly Gln Pro Thr Ala Ser Pro Phe 5 10 15 20 ccg cta ctg ctg ctg gcg gtg ctg agc ggc ccg gta tcc ggc cgc gtc 210 Pro Leu Leu Leu Leu Ala Val Leu Ser Gly Pro Val Ser Gly Arg Val 25 30 35 ccc cgc tcg gtg ccc aga acc tcg ctt cca atc tct gag gct gac tcc 258 Pro Arg Ser Val Pro Arg Thr Ser Leu Pro Ile Ser Glu Ala Asp Ser 40 45 50 tgt ctc acc cgg ttc gca gtc cct cac aca tac aat tac tct gtt ctc 306 Cys Leu Thr Arg Phe Ala Val Pro His Thr Tyr Asn Tyr Ser Val Leu 55 60 65 ctt gtg gat cct gcc tcc cac aca ctt tat gtt ggc gcc cgg gac acc 354 Leu Val Asp Pro Ala Ser His Thr Leu Tyr Val Gly Ala Arg Asp Thr 70 75 80 atc ttc gct tta tcc ctg ccc ttc tca ggg gag aga ccc cgc agg att 402 Ile Phe Ala Leu Ser Leu Pro Phe Ser Gly Glu Arg Pro Arg Arg Ile 85 90 95 100 gac tgg atg gtt cct gag gct cac aga cag aac tgt agg aag aaa ggc 450 Asp Trp Met Val Pro Glu Ala His Arg Gln Asn Cys Arg Lys Lys Gly 105 110 115 aag aaa gag gac gaa tgt cac aat ttt gtc cag att ctc gcc att gcc 498 Lys Lys Glu Asp Glu Cys His Asn Phe Val Gln Ile Leu Ala Ile Ala 120 125 130 aat gcc tct cac ctc ctc act tgt ggc acc ttc gct ttt gat ccg aag 546 Asn Ala Ser His Leu Leu Thr Cys Gly Thr Phe Ala Phe Asp Pro Lys 135 140 145 tgc ggg gtt att gat gtg tcc agg ttc cag cag gtt gaa aga ctt gag 594 Cys Gly Val Ile Asp Val Ser Arg Phe Gln Gln Val Glu Arg Leu Glu 150 155 160 agt ggc cgg ggg aaa tgt cct ttt gag cca gct cag cgg tca gca gct 642 Ser Gly Arg Gly Lys Cys Pro Phe Glu Pro Ala Gln Arg Ser Ala Ala 165 170 175 180 gta atg gct ggg ggg gtc ctc tat gct gcc act gtg aaa aac tac ctg 690 Val Met Ala Gly Gly Val Leu Tyr Ala Ala Thr Val Lys Asn Tyr Leu 185 190 195 ggg acg gag cca att atc acc aga gca gtg ggt cgt gcc gag gac tgg 738 Gly Thr Glu Pro Ile Ile Thr Arg Ala Val Gly Arg Ala Glu Asp Trp 200 205 210 att cgg aca gat acc ttg cct tcc tgg ctg aac gcc cca gcc ttt gtc 786 Ile Arg Thr Asp Thr Leu Pro Ser Trp Leu Asn Ala Pro Ala Phe Val 215 220 225 gca gcc gtg gcc ttg agc cca gcc gaa tgg ggg gat gaa gat gga gac 834 Ala Ala Val Ala Leu Ser Pro Ala Glu Trp Gly Asp Glu Asp Gly Asp 230 235 240 gac gaa atc tac ttc ttc ttt acg gag act tcc cga gca ttt gac tca 882 Asp Glu Ile Tyr Phe Phe Phe Thr Glu Thr Ser Arg Ala Phe Asp Ser 245 250 255 260 tac gag cgc att aaa gtc cca cgg gtg gcc cgt gtg tgt gcg ggg gac 930 Tyr Glu Arg Ile Lys Val Pro Arg Val Ala Arg Val Cys Ala Gly Asp 265 270 275 ctc ggg ggc cgg aag acc ctc cag cag aga tgg acg acg ttt ttg aaa 978 Leu Gly Gly Arg Lys Thr Leu Gln Gln Arg Trp Thr Thr Phe Leu Lys 280 285 290 gct gac ctg ctc tgt cca ggg cct gag cat ggc cgg gcc tcc agt gtc 1026 Ala Asp Leu Leu Cys Pro Gly Pro Glu His Gly Arg Ala Ser Ser Val 295 300 305 ctg cag gat gtt gct gtg ctt cga cct gag ctt ggg gca ggg act ccc 1074 Leu Gln Asp Val Ala Val Leu Arg Pro Glu Leu Gly Ala Gly Thr Pro 310 315 320 atc ttt tat ggc atc ttt tct tcc cag tgg gag ggg gct act atc tct 1122 Ile Phe Tyr Gly Ile Phe Ser Ser Gln Trp Glu Gly Ala Thr Ile Ser 325 330 335 340 gct gtc tgt gcc ttc cga cca caa gac att cgg aca gtg ctg aat ggt 1170 Ala Val Cys Ala Phe Arg Pro Gln Asp Ile Arg Thr Val Leu Asn Gly 345 350 355 ccc ttc aga gaa cta aaa cat gac tgc aac aga gga ctg cct gtc gtg 1218 Pro Phe Arg Glu Leu Lys His Asp Cys Asn Arg Gly Leu Pro Val Val 360 365 370 gac aat gat gtg ccc cag ccc aga cct gga gag tgc atc acc aac aac 1266 Asp Asn Asp Val Pro Gln Pro Arg Pro Gly Glu Cys Ile Thr Asn Asn 375 380 385 atg aag ctc cgg cac ttt ggc tca tct ctc tcc ctg cct gac cgc gta 1314 Met Lys Leu Arg His Phe Gly Ser Ser Leu Ser Leu Pro Asp Arg Val 390 395 400 ctc acc ttc atc cgg gac cac cca ctc atg gac agg cca gtg ttt cca 1362 Leu Thr Phe Ile Arg Asp His Pro Leu Met Asp Arg Pro Val Phe Pro 405 410 415 420 gct gat ggc cac ccc ctg ctg gtc act aca gat aca gcc tat ctc aga 1410 Ala Asp Gly His Pro Leu Leu Val Thr Thr Asp Thr Ala Tyr Leu Arg 425 430 435 gtc gtg gcc cac agg gtg acc agc ctc tca ggg aaa gag tat gat gtg 1458 Val Val Ala His Arg Val Thr Ser Leu Ser Gly Lys Glu Tyr Asp Val 440 445 450 ctc tac ctg ggg aca gag gat gga cac ctc cac cga gca gtg cgg atc 1506 Leu Tyr Leu Gly Thr Glu Asp Gly His Leu His Arg Ala Val Arg Ile 455 460 465 gga gct cag ctc agc gtt ctt gaa gat ctg gcc tta ttc cca gag cca 1554 Gly Ala Gln Leu Ser Val Leu Glu Asp Leu Ala Leu Phe Pro Glu Pro 470 475 480 cag cca gtt gag aac atg aaa ttg tac cac agc tgg ctc ctg gtt ggc 1602 Gln Pro Val Glu Asn Met Lys Leu Tyr His Ser Trp Leu Leu Val Gly 485 490 495 500 tcc cgt act gag gtg aca caa gtg aat aca acc aac tgt ggc cgt ctc 1650 Ser Arg Thr Glu Val Thr Gln Val Asn Thr Thr Asn Cys Gly Arg Leu 505 510 515 cag agc tgc tca gag tgc atc ctg gcc cag gac cca gtc tgt gcc tgg 1698 Gln Ser Cys Ser Glu Cys Ile Leu Ala Gln Asp Pro Val Cys Ala Trp 520 525 530 agc ttc cgg ctg gat gag tgt gtg gcc cat gcc ggg gag cac cga ggg 1746 Ser Phe Arg Leu Asp Glu Cys Val Ala His Ala Gly Glu His Arg Gly 535 540 545 ttg gtc caa gac ata gag tca gca gat gtc tcc tct ttg tgt cct aaa 1794 Leu Val Gln Asp Ile Glu Ser Ala Asp Val Ser Ser Leu Cys Pro Lys 550 555 560 gag cct gga gaa cgt cca gta gtg ttt gaa gtt ccc gtg gct aca gct 1842 Glu Pro Gly Glu Arg Pro Val Val Phe Glu Val Pro Val Ala Thr Ala 565 570 575 580 gcg cat gtg gtc ttg cca tgt tct cca agc tca gca tgg gca tcc tgt 1890 Ala His Val Val Leu Pro Cys Ser Pro Ser Ser Ala Trp Ala Ser Cys 585 590 595 gtg tgg cac cag ccc agt gga gtg act gca ctc acc ccc cgg cgg gat 1938 Val Trp His Gln Pro Ser Gly Val Thr Ala Leu Thr Pro Arg Arg Asp 600 605 610 gga ctg gag gtg gtg gtg acc cca ggg gcc atg ggc gct tat gcc tgt 1986 Gly Leu Glu Val Val Val Thr Pro Gly Ala Met Gly Ala Tyr Ala Cys 615 620 625 gaa tgt cag gag ggt ggg gca gcc cat gtg gta gca gct tac agc ttg 2034 Glu Cys Gln Glu Gly Gly Ala Ala His Val Val Ala Ala Tyr Ser Leu 630 635 640 gta tgg ggc agc cag cga gat gct ccg agc cgg gcc cac aca gtg ggg 2082 Val Trp Gly Ser Gln Arg Asp Ala Pro Ser Arg Ala His Thr Val Gly 645 650 655 660 gcg gga ctg gct ggc ttc ttc ttg ggg att ctc gca gca tcc ctg act 2130 Ala Gly Leu Ala Gly Phe Phe Leu Gly Ile Leu Ala Ala Ser Leu Thr 665 670 675 ctc att ctg att ggt cgg cgt cag cag cga cgg cga cag agg gaa ctt 2178 Leu Ile Leu Ile Gly Arg Arg Gln Gln Arg Arg Arg Gln Arg Glu Leu 680 685 690 ctg gct aga gac aag gtg ggc ctg gac ctg ggg gct cca cct tct ggg 2226 Leu Ala Arg Asp Lys Val Gly Leu Asp Leu Gly Ala Pro Pro Ser Gly 695 700 705 acc aca agc tac agc caa gac cct ccc tcc ccc tct cct gaa gat gag 2274 Thr Thr Ser Tyr Ser Gln Asp Pro Pro Ser Pro Ser Pro Glu Asp Glu 710 715 720 cgg ttg ccg ctg gcc ctg gcc aag agg ggc agt ggc ttt ggt gga ttc 2322 Arg Leu Pro Leu Ala Leu Ala Lys Arg Gly Ser Gly Phe Gly Gly Phe 725 730 735 740 tca cca ccc ttc ctg ctt gat cct tgc cca agc cca gcc cac att cgg 2370 Ser Pro Pro Phe Leu Leu Asp Pro Cys Pro Ser Pro Ala His Ile Arg 745 750 755 cta act ggg gct cct cta gcc aca tgt gat gaa aca tcc atc 2412 Leu Thr Gly Ala Pro Leu Ala Thr Cys Asp Glu Thr Ser Ile 760 765 770 tagagctggg caaatgacca ctagtgtata agtgatcact ggaacggagt gaccactgag 2472 atgctggggg tcactgggcc tggaagacca tcccagcctc tgagttctct ttgagtatga 2532 gtgattactt ggattttagt atctgttctc tctgagcctg gatgggcttg gggccagacc 2592 tttgcctgat tcctgattcc catgagaaat cagaactgct ttctgcagca aatcagggct 2652 tccccctaac atctgaactc ctgtaaacct tcatccctgg ccccctatct tgggcccatt 2712 agttttgggg atggggcaca gggcatagct atgactttgc tttctggttg gagcctggcc 2772 ggaaggaaga gccctggagg tggttggggg caaatgtgcc ctgagtcctt ggggtggttc 2832 tgcttattct tcaagtttat ctgaatctgt ggggagtgca tgatccccat gttgcaatat 2892 ggagtctctg ccctgagatc ttccccatct cagttttcct tccatgaaag agtacgtgta 2952 aatacatagt gttcataag 2971 <210> 66 <211> 770 <212> PRT <213> Homo sapiens <400> 66 Met Pro Ala Ser Ala Ala Arg Pro Arg Pro Gly Pro Gly Gln Pro Thr 1 5 10 15 Ala Ser Pro Phe Pro Leu Leu Leu Leu Ala Val Leu Ser Gly Pro Val 20 25 30 Ser Gly Arg Val Pro Arg Ser Val Pro Arg Thr Ser Leu Pro Ile Ser 35 40 45 Glu Ala Asp Ser Cys Leu Thr Arg Phe Ala Val Pro His Thr Tyr Asn 50 55 60 Tyr Ser Val Leu Leu Val Asp Pro Ala Ser His Thr Leu Tyr Val Gly 65 70 75 80 Ala Arg Asp Thr Ile Phe Ala Leu Ser Leu Pro Phe Ser Gly Glu Arg 85 90 95 Pro Arg Arg Ile Asp Trp Met Val Pro Glu Ala His Arg Gln Asn Cys 100 105 110 Arg Lys Lys Gly Lys Lys Glu Asp Glu Cys His Asn Phe Val Gln Ile 115 120 125 Leu Ala Ile Ala Asn Ala Ser His Leu Leu Thr Cys Gly Thr Phe Ala 130 135 140 Phe Asp Pro Lys Cys Gly Val Ile Asp Val Ser Arg Phe Gln Gln Val 145 150 155 160 Glu Arg Leu Glu Ser Gly Arg Gly Lys Cys Pro Phe Glu Pro Ala Gln 165 170 175 Arg Ser Ala Ala Val Met Ala Gly Gly Val Leu Tyr Ala Ala Thr Val 180 185 190 Lys Asn Tyr Leu Gly Thr Glu Pro Ile Ile Thr Arg Ala Val Gly Arg 195 200 205 Ala Glu Asp Trp Ile Arg Thr Asp Thr Leu Pro Ser Trp Leu Asn Ala 210 215 220 Pro Ala Phe Val Ala Ala Val Ala Leu Ser Pro Ala Glu Trp Gly Asp 225 230 235 240 Glu Asp Gly Asp Asp Glu Ile Tyr Phe Phe Phe Thr Glu Thr Ser Arg 245 250 255 Ala Phe Asp Ser Tyr Glu Arg Ile Lys Val Pro Arg Val Ala Arg Val 260 265 270 Cys Ala Gly Asp Leu Gly Gly Arg Lys Thr Leu Gln Gln Arg Trp Thr 275 280 285 Thr Phe Leu Lys Ala Asp Leu Leu Cys Pro Gly Pro Glu His Gly Arg 290 295 300 Ala Ser Ser Val Leu Gln Asp Val Ala Val Leu Arg Pro Glu Leu Gly 305 310 315 320 Ala Gly Thr Pro Ile Phe Tyr Gly Ile Phe Ser Ser Gln Trp Glu Gly 325 330 335 Ala Thr Ile Ser Ala Val Cys Ala Phe Arg Pro Gln Asp Ile Arg Thr 340 345 350 Val Leu Asn Gly Pro Phe Arg Glu Leu Lys His Asp Cys Asn Arg Gly 355 360 365 Leu Pro Val Val Asp Asn Asp Val Pro Gln Pro Arg Pro Gly Glu Cys 370 375 380 Ile Thr Asn Asn Met Lys Leu Arg His Phe Gly Ser Ser Leu Ser Leu 385 390 395 400 Pro Asp Arg Val Leu Thr Phe Ile Arg Asp His Pro Leu Met Asp Arg 405 410 415 Pro Val Phe Pro Ala Asp Gly His Pro Leu Leu Val Thr Thr Asp Thr 420 425 430 Ala Tyr Leu Arg Val Val Ala His Arg Val Thr Ser Leu Ser Gly Lys 435 440 445 Glu Tyr Asp Val Leu Tyr Leu Gly Thr Glu Asp Gly His Leu His Arg 450 455 460 Ala Val Arg Ile Gly Ala Gln Leu Ser Val Leu Glu Asp Leu Ala Leu 465 470 475 480 Phe Pro Glu Pro Gln Pro Val Glu Asn Met Lys Leu Tyr His Ser Trp 485 490 495 Leu Leu Val Gly Ser Arg Thr Glu Val Thr Gln Val Asn Thr Thr Asn 500 505 510 Cys Gly Arg Leu Gln Ser Cys Ser Glu Cys Ile Leu Ala Gln Asp Pro 515 520 525 Val Cys Ala Trp Ser Phe Arg Leu Asp Glu Cys Val Ala His Ala Gly 530 535 540 Glu His Arg Gly Leu Val Gln Asp Ile Glu Ser Ala Asp Val Ser Ser 545 550 555 560 Leu Cys Pro Lys Glu Pro Gly Glu Arg Pro Val Val Phe Glu Val Pro 565 570 575 Val Ala Thr Ala Ala His Val Val Leu Pro Cys Ser Pro Ser Ser Ala 580 585 590 Trp Ala Ser Cys Val Trp His Gln Pro Ser Gly Val Thr Ala Leu Thr 595 600 605 Pro Arg Arg Asp Gly Leu Glu Val Val Val Thr Pro Gly Ala Met Gly 610 615 620 Ala Tyr Ala Cys Glu Cys Gln Glu Gly Gly Ala Ala His Val Val Ala 625 630 635 640 Ala Tyr Ser Leu Val Trp Gly Ser Gln Arg Asp Ala Pro Ser Arg Ala 645 650 655 His Thr Val Gly Ala Gly Leu Ala Gly Phe Phe Leu Gly Ile Leu Ala 660 665 670 Ala Ser Leu Thr Leu Ile Leu Ile Gly Arg Arg Gln Gln Arg Arg Arg 675 680 685 Gln Arg Glu Leu Leu Ala Arg Asp Lys Val Gly Leu Asp Leu Gly Ala 690 695 700 Pro Pro Ser Gly Thr Thr Ser Tyr Ser Gln Asp Pro Pro Ser Pro Ser 705 710 715 720 Pro Glu Asp Glu Arg Leu Pro Leu Ala Leu Ala Lys Arg Gly Ser Gly 725 730 735 Phe Gly Gly Phe Ser Pro Pro Phe Leu Leu Asp Pro Cys Pro Ser Pro 740 745 750 Ala His Ile Arg Leu Thr Gly Ala Pro Leu Ala Thr Cys Asp Glu Thr 755 760 765 Ser Ile 770 <210> 67 <211> 2244 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (161)..(2059) <400> 67 aatattgcca ggtccactga tctcaaatag cccagcaacc attttccaag ggacttctgg 60 caaccaggta accataacag ttgtgccaaa tacgagtttt gcacctgcaa ctgtgagtca 120 gggaaatgca actcagctca ttgctccagc aggaattacc atg agc gga acg cag 175 Met Ser Gly Thr Gln 1 5 aca gga gtt gga ctt cca gta caa acg ctt cca gcc act caa gca tct 223 Thr Gly Val Gly Leu Pro Val Gln Thr Leu Pro Ala Thr Gln Ala Ser 10 15 20 cct gct gga caa tca tca tgt act act gct act ccc cca ttc aaa ggt 271 Pro Ala Gly Gln Ser Ser Cys Thr Thr Ala Thr Pro Pro Phe Lys Gly 25 30 35 gat aaa ata att tgc caa aag gag gag gaa gca aag gaa gca aca ggt 319 Asp Lys Ile Ile Cys Gln Lys Glu Glu Glu Ala Lys Glu Ala Thr Gly 40 45 50 tta cat gtt cat gaa cgt aaa att gaa gtc atg gag aac ccg tcc tgc 367 Leu His Val His Glu Arg Lys Ile Glu Val Met Glu Asn Pro Ser Cys 55 60 65 cga cga gga gcc aca aac acc agc aat ggg gat aca aag gaa aat gaa 415 Arg Arg Gly Ala Thr Asn Thr Ser Asn Gly Asp Thr Lys Glu Asn Glu 70 75 80 85 atg cat gtg gga agt ctt tta aat ggg aga aag tac agt gac tca agt 463 Met His Val Gly Ser Leu Leu Asn Gly Arg Lys Tyr Ser Asp Ser Ser 90 95 100 cta cct cct tca aac tca ggg aaa att caa agt gag act aat cag tgc 511 Leu Pro Pro Ser Asn Ser Gly Lys Ile Gln Ser Glu Thr Asn Gln Cys 105 110 115 tca cta atc agt aat ggg cca tca ttg gaa tta ggt gag aat gga gca 559 Ser Leu Ile Ser Asn Gly Pro Ser Leu Glu Leu Gly Glu Asn Gly Ala 120 125 130 tct ggg aaa cag aac tca gaa caa ata gac atg caa gat atc aaa agt 607 Ser Gly Lys Gln Asn Ser Glu Gln Ile Asp Met Gln Asp Ile Lys Ser 135 140 145 gat ttg aga aaa ccg cta gtt aat gga atc tgt gat ttt gat aaa gga 655 Asp Leu Arg Lys Pro Leu Val Asn Gly Ile Cys Asp Phe Asp Lys Gly 150 155 160 165 gat ggt tct cat tta agc aaa aac att cca aat cat aaa act tcc aat 703 Asp Gly Ser His Leu Ser Lys Asn Ile Pro Asn His Lys Thr Ser Asn 170 175 180 cat gta gga aat ggt gag ata tct cca atg gaa cca caa ggg act tta 751 His Val Gly Asn Gly Glu Ile Ser Pro Met Glu Pro Gln Gly Thr Leu 185 190 195 gat atc act cag caa gat act gcc aaa ggt gat caa cta gaa aga att 799 Asp Ile Thr Gln Gln Asp Thr Ala Lys Gly Asp Gln Leu Glu Arg Ile 200 205 210 tct aat gga cct gta tta act ttg ggt ggt tca tct gtg agc agt ata 847 Ser Asn Gly Pro Val Leu Thr Leu Gly Gly Ser Ser Val Ser Ser Ile 215 220 225 cag gag gct tca aat gcg gca aca cag caa ttt agt ggt act gat ttg 895 Gln Glu Ala Ser Asn Ala Ala Thr Gln Gln Phe Ser Gly Thr Asp Leu 230 235 240 245 ctt aat gga cct cta gct tca agt ttg aat tca gat gtg cct cag caa 943 Leu Asn Gly Pro Leu Ala Ser Ser Leu Asn Ser Asp Val Pro Gln Gln 250 255 260 cgc cca agt gta gtt gtc tca cca cat tct aca acc tct gtt ata cag 991 Arg Pro Ser Val Val Val Ser Pro His Ser Thr Thr Ser Val Ile Gln 265 270 275 gga cat caa atc ata gca gtt ccc gac tca gga tca aaa gta tcc cat 1039 Gly His Gln Ile Ile Ala Val Pro Asp Ser Gly Ser Lys Val Ser His 280 285 290 tct cct gcc cta tca tct gac gtt cgg tct aca aat ggc aca gca gaa 1087 Ser Pro Ala Leu Ser Ser Asp Val Arg Ser Thr Asn Gly Thr Ala Glu 295 300 305 tgc aaa act gta aag agg cca gca gag gat act gat agg gaa aca gtc 1135 Cys Lys Thr Val Lys Arg Pro Ala Glu Asp Thr Asp Arg Glu Thr Val 310 315 320 325 gca gga att cca aat aaa gta gga gtt aga att gtt aca atc agt gac 1183 Ala Gly Ile Pro Asn Lys Val Gly Val Arg Ile Val Thr Ile Ser Asp 330 335 340 ccc aac aat gct ggc tgc agc gca aca atg gtt gct gtg cca gca gga 1231 Pro Asn Asn Ala Gly Cys Ser Ala Thr Met Val Ala Val Pro Ala Gly 345 350 355 gca gat cca agc act gta gct aaa gta gca ata gaa agt gct gtt cag 1279 Ala Asp Pro Ser Thr Val Ala Lys Val Ala Ile Glu Ser Ala Val Gln 360 365 370 caa aag caa cag cat cca cca aca tat gta cag aat gtg gtc ccg cag 1327 Gln Lys Gln Gln His Pro Pro Thr Tyr Val Gln Asn Val Val Pro Gln 375 380 385 aac act cct atg cca cct tca cca gct gta caa gtg cag ggc cag cct 1375 Asn Thr Pro Met Pro Pro Ser Pro Ala Val Gln Val Gln Gly Gln Pro 390 395 400 405 aac agt tct cag cct tct cca ttc agt gga tcc agt cag cct gga gat 1423 Asn Ser Ser Gln Pro Ser Pro Phe Ser Gly Ser Ser Gln Pro Gly Asp 410 415 420 cca atg aga aaa cct gga cag aac ttc atg tgt ctg tgg cag tct tgt 1471 Pro Met Arg Lys Pro Gly Gln Asn Phe Met Cys Leu Trp Gln Ser Cys 425 430 435 aaa aag tgg ttt cag aca ccc tca cag gtt ttc tac cat gca gca act 1519 Lys Lys Trp Phe Gln Thr Pro Ser Gln Val Phe Tyr His Ala Ala Thr 440 445 450 gaa cat gga gga aaa gat gta tat cca ggg cag tgt ctt tgg gaa ggt 1567 Glu His Gly Gly Lys Asp Val Tyr Pro Gly Gln Cys Leu Trp Glu Gly 455 460 465 tgt gag cct ttt cag cga cag cgg ttt tct ttt att acc cac ttg cag 1615 Cys Glu Pro Phe Gln Arg Gln Arg Phe Ser Phe Ile Thr His Leu Gln 470 475 480 485 gat aag cac tgt tca aag gat gcc cta ctt gca gga tta aaa caa gat 1663 Asp Lys His Cys Ser Lys Asp Ala Leu Leu Ala Gly Leu Lys Gln Asp 490 495 500 gaa cca gga cac gca gga agt cag aag tct tct acc aag cag cca act 1711 Glu Pro Gly His Ala Gly Ser Gln Lys Ser Ser Thr Lys Gln Pro Thr 505 510 515 gta ggg ggc aca agc tca act cct aga gca caa aag gcc att gtg aat 1759 Val Gly Gly Thr Ser Ser Thr Pro Arg Ala Gln Lys Ala Ile Val Asn 520 525 530 cat ccc agt gct gca ctt atg gct ctg agg aga gga tca aga aac ctt 1807 His Pro Ser Ala Ala Leu Met Ala Leu Arg Arg Gly Ser Arg Asn Leu 535 540 545 gtc ttt cga gat ttt aca gat gaa aaa gag gga cca ata act aaa cac 1855 Val Phe Arg Asp Phe Thr Asp Glu Lys Glu Gly Pro Ile Thr Lys His 550 555 560 565 atc cga cta aca gct gcc tta ata tta aaa aat att ggt aaa tat tca 1903 Ile Arg Leu Thr Ala Ala Leu Ile Leu Lys Asn Ile Gly Lys Tyr Ser 570 575 580 gaa tgt ggt cgc aga ttg tta aag aga cat gaa aat aac tta tca gtg 1951 Glu Cys Gly Arg Arg Leu Leu Lys Arg His Glu Asn Asn Leu Ser Val 585 590 595 cta gcc att agt aac atg gaa gct tcc tcc acc ctt gcc aaa tgc ctt 1999 Leu Ala Ile Ser Asn Met Glu Ala Ser Ser Thr Leu Ala Lys Cys Leu 600 605 610 tat gaa ctt aat ttt aca gtt cag agt aag gaa caa gaa aaa gac tca 2047 Tyr Glu Leu Asn Phe Thr Val Gln Ser Lys Glu Gln Glu Lys Asp Ser 615 620 625 gaa atg ctg cag tgaaaaataa ttccacttac acagtggggg actcaaagtc 2099 Glu Met Leu Gln 630 agccacattt cacatactgt tactgaagaa agcaccaagt cttaatggaa caaagaccat 2159 agaatgaatt attttatctc ctcccatgat gctgagagga agcttcgtat tctgatctct 2219 gagtgaatcc ctttgttctc tgttt 2244 <210> 68 <211> 633 <212> PRT <213> Homo sapiens <400> 68 Met Ser Gly Thr Gln Thr Gly Val Gly Leu Pro Val Gln Thr Leu Pro 1 5 10 15 Ala Thr Gln Ala Ser Pro Ala Gly Gln Ser Ser Cys Thr Thr Ala Thr 20 25 30 Pro Pro Phe Lys Gly Asp Lys Ile Ile Cys Gln Lys Glu Glu Glu Ala 35 40 45 Lys Glu Ala Thr Gly Leu His Val His Glu Arg Lys Ile Glu Val Met 50 55 60 Glu Asn Pro Ser Cys Arg Arg Gly Ala Thr Asn Thr Ser Asn Gly Asp 65 70 75 80 Thr Lys Glu Asn Glu Met His Val Gly Ser Leu Leu Asn Gly Arg Lys 85 90 95 Tyr Ser Asp Ser Ser Leu Pro Pro Ser Asn Ser Gly Lys Ile Gln Ser 100 105 110 Glu Thr Asn Gln Cys Ser Leu Ile Ser Asn Gly Pro Ser Leu Glu Leu 115 120 125 Gly Glu Asn Gly Ala Ser Gly Lys Gln Asn Ser Glu Gln Ile Asp Met 130 135 140 Gln Asp Ile Lys Ser Asp Leu Arg Lys Pro Leu Val Asn Gly Ile Cys 145 150 155 160 Asp Phe Asp Lys Gly Asp Gly Ser His Leu Ser Lys Asn Ile Pro Asn 165 170 175 His Lys Thr Ser Asn His Val Gly Asn Gly Glu Ile Ser Pro Met Glu 180 185 190 Pro Gln Gly Thr Leu Asp Ile Thr Gln Gln Asp Thr Ala Lys Gly Asp 195 200 205 Gln Leu Glu Arg Ile Ser Asn Gly Pro Val Leu Thr Leu Gly Gly Ser 210 215 220 Ser Val Ser Ser Ile Gln Glu Ala Ser Asn Ala Ala Thr Gln Gln Phe 225 230 235 240 Ser Gly Thr Asp Leu Leu Asn Gly Pro Leu Ala Ser Ser Leu Asn Ser 245 250 255 Asp Val Pro Gln Gln Arg Pro Ser Val Val Val Ser Pro His Ser Thr 260 265 270 Thr Ser Val Ile Gln Gly His Gln Ile Ile Ala Val Pro Asp Ser Gly 275 280 285 Ser Lys Val Ser His Ser Pro Ala Leu Ser Ser Asp Val Arg Ser Thr 290 295 300 Asn Gly Thr Ala Glu Cys Lys Thr Val Lys Arg Pro Ala Glu Asp Thr 305 310 315 320 Asp Arg Glu Thr Val Ala Gly Ile Pro Asn Lys Val Gly Val Arg Ile 325 330 335 Val Thr Ile Ser Asp Pro Asn Asn Ala Gly Cys Ser Ala Thr Met Val 340 345 350 Ala Val Pro Ala Gly Ala Asp Pro Ser Thr Val Ala Lys Val Ala Ile 355 360 365 Glu Ser Ala Val Gln Gln Lys Gln Gln His Pro Pro Thr Tyr Val Gln 370 375 380 Asn Val Val Pro Gln Asn Thr Pro Met Pro Pro Ser Pro Ala Val Gln 385 390 395 400 Val Gln Gly Gln Pro Asn Ser Ser Gln Pro Ser Pro Phe Ser Gly Ser 405 410 415 Ser Gln Pro Gly Asp Pro Met Arg Lys Pro Gly Gln Asn Phe Met Cys 420 425 430 Leu Trp Gln Ser Cys Lys Lys Trp Phe Gln Thr Pro Ser Gln Val Phe 435 440 445 Tyr His Ala Ala Thr Glu His Gly Gly Lys Asp Val Tyr Pro Gly Gln 450 455 460 Cys Leu Trp Glu Gly Cys Glu Pro Phe Gln Arg Gln Arg Phe Ser Phe 465 470 475 480 Ile Thr His Leu Gln Asp Lys His Cys Ser Lys Asp Ala Leu Leu Ala 485 490 495 Gly Leu Lys Gln Asp Glu Pro Gly His Ala Gly Ser Gln Lys Ser Ser 500 505 510 Thr Lys Gln Pro Thr Val Gly Gly Thr Ser Ser Thr Pro Arg Ala Gln 515 520 525 Lys Ala Ile Val Asn His Pro Ser Ala Ala Leu Met Ala Leu Arg Arg 530 535 540 Gly Ser Arg Asn Leu Val Phe Arg Asp Phe Thr Asp Glu Lys Glu Gly 545 550 555 560 Pro Ile Thr Lys His Ile Arg Leu Thr Ala Ala Leu Ile Leu Lys Asn 565 570 575 Ile Gly Lys Tyr Ser Glu Cys Gly Arg Arg Leu Leu Lys Arg His Glu 580 585 590 Asn Asn Leu Ser Val Leu Ala Ile Ser Asn Met Glu Ala Ser Ser Thr 595 600 605 Leu Ala Lys Cys Leu Tyr Glu Leu Asn Phe Thr Val Gln Ser Lys Glu 610 615 620 Gln Glu Lys Asp Ser Glu Met Leu Gln 625 630 <210> 69 <211> 3253 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (9)..(2588) <400> 69 gagggaag atg gca cct gcc ggc tgc tgc tgc tgc tgc tgc ttc tgg ggc 50 Met Ala Pro Ala Gly Cys Cys Cys Cys Cys Cys Phe Trp Gly 1 5 10 ggc gct gtg gcc gcc gcg ggc gcc gcc cgg cgt gtc ctg ctg ctg ctg 98 Gly Ala Val Ala Ala Ala Gly Ala Ala Arg Arg Val Leu Leu Leu Leu 15 20 25 30 ctg ctg ggg gtc ctg tcc gct ggg ctg cgg cca ggc gcc ctg gcc acc 146 Leu Leu Gly Val Leu Ser Ala Gly Leu Arg Pro Gly Ala Leu Ala Thr 35 40 45 gag cac tac tcg ccg ctc tcc ctg ctc aag cag gag ctg cag cac cgg 194 Glu His Tyr Ser Pro Leu Ser Leu Leu Lys Gln Glu Leu Gln His Arg 50 55 60 cag cag cag gag gcc ccg gcg ggc ggc ggc ggc tgc agc ccg cag tcc 242 Gln Gln Gln Glu Ala Pro Ala Gly Gly Gly Gly Cys Ser Pro Gln Ser 65 70 75 ggg gac tgg ggg gac cag tac tct gcc gag tgc ggc gag tca tcc ttt 290 Gly Asp Trp Gly Asp Gln Tyr Ser Ala Glu Cys Gly Glu Ser Ser Phe 80 85 90 ttg aac ttc cat gac tca gac tgc gaa ccc aag gga tca tca ccc tgt 338 Leu Asn Phe His Asp Ser Asp Cys Glu Pro Lys Gly Ser Ser Pro Cys 95 100 105 110 gac tcc ttg ctt tcc ctc aac act gag aag att ctg agc cag gcc aag 386 Asp Ser Leu Leu Ser Leu Asn Thr Glu Lys Ile Leu Ser Gln Ala Lys 115 120 125 tct att gca gaa cag aag aga ttc ccg ttt gcc act gat aat gac agc 434 Ser Ile Ala Glu Gln Lys Arg Phe Pro Phe Ala Thr Asp Asn Asp Ser 130 135 140 aca aat gaa gag tta gct att gct tat gtc ttg att ggc agt ggt ctg 482 Thr Asn Glu Glu Leu Ala Ile Ala Tyr Val Leu Ile Gly Ser Gly Leu 145 150 155 tat gat gaa gca ata cgg cat ttt tca aca atg ctt cag gag gag cct 530 Tyr Asp Glu Ala Ile Arg His Phe Ser Thr Met Leu Gln Glu Glu Pro 160 165 170 gat ctg gtt agt gca att tat ggc cga ggg ata gcc tat gga aag aag 578 Asp Leu Val Ser Ala Ile Tyr Gly Arg Gly Ile Ala Tyr Gly Lys Lys 175 180 185 190 gga cta cat gac att aag aat gct gag ctt gct ctg ttc gaa ctg agc 626 Gly Leu His Asp Ile Lys Asn Ala Glu Leu Ala Leu Phe Glu Leu Ser 195 200 205 cga gta att acc ttg gaa cca gat cgt cca gag gta ttt gag cag cga 674 Arg Val Ile Thr Leu Glu Pro Asp Arg Pro Glu Val Phe Glu Gln Arg 210 215 220 gca gaa att ctg tcc cct ctg gga cga att aat gaa gca gtg aat gac 722 Ala Glu Ile Leu Ser Pro Leu Gly Arg Ile Asn Glu Ala Val Asn Asp 225 230 235 ctc act aaa gct atc caa ctg cag ccc tca gca cgg ctg tac aga cat 770 Leu Thr Lys Ala Ile Gln Leu Gln Pro Ser Ala Arg Leu Tyr Arg His 240 245 250 cgg gga acc ctg tac ttc ata tca gag gac tat gca aca gcc cat gaa 818 Arg Gly Thr Leu Tyr Phe Ile Ser Glu Asp Tyr Ala Thr Ala His Glu 255 260 265 270 gac ttt cag cag tcc tta gaa ctg aac aaa aac cag cct ata gct atg 866 Asp Phe Gln Gln Ser Leu Glu Leu Asn Lys Asn Gln Pro Ile Ala Met 275 280 285 cta tac aaa ggt tta act ttc ttt cac aga gga ctt ctg aag gaa gct 914 Leu Tyr Lys Gly Leu Thr Phe Phe His Arg Gly Leu Leu Lys Glu Ala 290 295 300 att gaa tcc ttc aaa gaa gct ttg aag cag aaa gtt gac ttt att gat 962 Ile Glu Ser Phe Lys Glu Ala Leu Lys Gln Lys Val Asp Phe Ile Asp 305 310 315 gca tat aaa agt cta ggg cag gca tat aga gaa ctg ggc aat ttt gaa 1010 Ala Tyr Lys Ser Leu Gly Gln Ala Tyr Arg Glu Leu Gly Asn Phe Glu 320 325 330 gca gcc act gag agc ttt caa aag gca ctg ttg ctc aac caa aat cat 1058 Ala Ala Thr Glu Ser Phe Gln Lys Ala Leu Leu Leu Asn Gln Asn His 335 340 345 350 gtg caa acc ctc cag ctc cgg gga atg atg ctc tac cac cac ggc agc 1106 Val Gln Thr Leu Gln Leu Arg Gly Met Met Leu Tyr His His Gly Ser 355 360 365 tta cag gaa gcc ctt aag aac ttt aag cgg tgt ctg cag cta gag cca 1154 Leu Gln Glu Ala Leu Lys Asn Phe Lys Arg Cys Leu Gln Leu Glu Pro 370 375 380 tat aat gaa gtg tgc cag tat atg aaa ggg ctc agc cat gtt gcc atg 1202 Tyr Asn Glu Val Cys Gln Tyr Met Lys Gly Leu Ser His Val Ala Met 385 390 395 gga cag ttt tat gaa ggg ata aaa gca caa aca aaa gtt atg ctg aat 1250 Gly Gln Phe Tyr Glu Gly Ile Lys Ala Gln Thr Lys Val Met Leu Asn 400 405 410 gat cct ctc cca ggc cag aag gct agc cct gag tat ctt aaa gta aag 1298 Asp Pro Leu Pro Gly Gln Lys Ala Ser Pro Glu Tyr Leu Lys Val Lys 415 420 425 430 tat ctc cga gag tac tct cga cat ctt cat gca cac ctt gat acc ccc 1346 Tyr Leu Arg Glu Tyr Ser Arg His Leu His Ala His Leu Asp Thr Pro 435 440 445 ctt acg gaa tat aac att gat gtg gat ctg cct gga agc ttt aag gac 1394 Leu Thr Glu Tyr Asn Ile Asp Val Asp Leu Pro Gly Ser Phe Lys Asp 450 455 460 cac tgg gct aaa aat ttg cct ttc ctc ata gaa gac tac gaa gag cag 1442 His Trp Ala Lys Asn Leu Pro Phe Leu Ile Glu Asp Tyr Glu Glu Gln 465 470 475 cca ggg ttg caa ccc cac ata aaa gat gtg tta cat cag aat ttt gag 1490 Pro Gly Leu Gln Pro His Ile Lys Asp Val Leu His Gln Asn Phe Glu 480 485 490 agt tat aag cct gaa gta cag gag ctg att tgt gtg gct gat cgt ttg 1538 Ser Tyr Lys Pro Glu Val Gln Glu Leu Ile Cys Val Ala Asp Arg Leu 495 500 505 510 gga tcc ctg atg caa tat gaa aca cct ggt ttc ctg cca aac aag aga 1586 Gly Ser Leu Met Gln Tyr Glu Thr Pro Gly Phe Leu Pro Asn Lys Arg 515 520 525 ata cac aga gct atg ggt ttg gcc gca ttg gag gtc atg caa gcc gtg 1634 Ile His Arg Ala Met Gly Leu Ala Ala Leu Glu Val Met Gln Ala Val 530 535 540 cag cgt aca tgg acc aac tcg aaa gtt cga atg aat ggg aag aca cgg 1682 Gln Arg Thr Trp Thr Asn Ser Lys Val Arg Met Asn Gly Lys Thr Arg 545 550 555 ttg atg cag tgg aga gac atg ttt gac att gca gtt aaa tgg aga agg 1730 Leu Met Gln Trp Arg Asp Met Phe Asp Ile Ala Val Lys Trp Arg Arg 560 565 570 att gct gac cca gac cag ccc gtg ctg tgg tta gat caa atg cca gca 1778 Ile Ala Asp Pro Asp Gln Pro Val Leu Trp Leu Asp Gln Met Pro Ala 575 580 585 590 cga agt ctt agc aga ggt ttt aac aac cac att aat tta atc agg ggt 1826 Arg Ser Leu Ser Arg Gly Phe Asn Asn His Ile Asn Leu Ile Arg Gly 595 600 605 cag gtg atc aac atg aga tac cta gaa tat ttt gag aaa ata ctt cat 1874 Gln Val Ile Asn Met Arg Tyr Leu Glu Tyr Phe Glu Lys Ile Leu His 610 615 620 ttt att aaa gac aga att ctt gtt tat cat gga gct aat aat cct aaa 1922 Phe Ile Lys Asp Arg Ile Leu Val Tyr His Gly Ala Asn Asn Pro Lys 625 630 635 gga ttg ctg gaa gtt cgg gaa gcc ctg gaa aag gta cac aaa gta gaa 1970 Gly Leu Leu Glu Val Arg Glu Ala Leu Glu Lys Val His Lys Val Glu 640 645 650 gac ctt ctt ccg att atg aag cag ttt aat act aaa acg aag gat ggg 2018 Asp Leu Leu Pro Ile Met Lys Gln Phe Asn Thr Lys Thr Lys Asp Gly 655 660 665 670 ttc acc gtg aac aca aaa gtt ccc agc ctt aaa gac caa ggg aag gaa 2066 Phe Thr Val Asn Thr Lys Val Pro Ser Leu Lys Asp Gln Gly Lys Glu 675 680 685 tat gat gga ttc aca atc acg att aca gga gac aaa gtt ggc aat ata 2114 Tyr Asp Gly Phe Thr Ile Thr Ile Thr Gly Asp Lys Val Gly Asn Ile 690 695 700 tta ttt tct gtg gaa act caa acc acg gaa gaa agg aca caa tta tat 2162 Leu Phe Ser Val Glu Thr Gln Thr Thr Glu Glu Arg Thr Gln Leu Tyr 705 710 715 cat gct gaa ata gat gca ctt tat aaa gat ttg aca gca aaa gga aaa 2210 His Ala Glu Ile Asp Ala Leu Tyr Lys Asp Leu Thr Ala Lys Gly Lys 720 725 730 gta ttg att ctt tca tca gaa ttt ggg gag gct gat gct gtc tgc aac 2258 Val Leu Ile Leu Ser Ser Glu Phe Gly Glu Ala Asp Ala Val Cys Asn 735 740 745 750 tta atc tta tcc tta gtt tat tac ttt tat aat tta atg cca ctc tct 2306 Leu Ile Leu Ser Leu Val Tyr Tyr Phe Tyr Asn Leu Met Pro Leu Ser 755 760 765 cga gga tcc agt gta att gct tac tcg gtc atc gtg gga gca ctg atg 2354 Arg Gly Ser Ser Val Ile Ala Tyr Ser Val Ile Val Gly Ala Leu Met 770 775 780 gca agt gga aaa gaa gta gca gga aaa att ccc aaa ggg aag tta gtc 2402 Ala Ser Gly Lys Glu Val Ala Gly Lys Ile Pro Lys Gly Lys Leu Val 785 790 795 gac ttt gaa gct atg aca gcc cct ggt tca gag gcc ttt agc aaa gtc 2450 Asp Phe Glu Ala Met Thr Ala Pro Gly Ser Glu Ala Phe Ser Lys Val 800 805 810 gcc aaa agc tgg atg aac ttg aaa agt att tca cct tct tat aag act 2498 Ala Lys Ser Trp Met Asn Leu Lys Ser Ile Ser Pro Ser Tyr Lys Thr 815 820 825 830 ctt cca tca gtt tca gaa acg ttt cca acg tta aga tcg atg att gag 2546 Leu Pro Ser Val Ser Glu Thr Phe Pro Thr Leu Arg Ser Met Ile Glu 835 840 845 gtg cta aac aca gac tct tct cca cgt tgt ctt aag aaa ctc 2588 Val Leu Asn Thr Asp Ser Ser Pro Arg Cys Leu Lys Lys Leu 850 855 860 tagttctgct gctgtattta tacaagtaaa gggccggacc tcttgcttct taagttattt 2648 tttaaaacat ggaattataa agaaattagg tcctctatta cttttgatac caatttttat 2708 aggaattgaa tacttgaaat cattttcttt acttttctga accataatga aaatcatgaa 2768 agaggctttc ggggggaaaa agctacttga cttggaggga aagcgtatgt attagccggc 2828 agcctgttgg ttcccactta taaagtcata taactccttc cttacagtaa aaaaaatttt 2888 cctcaacaac taaaatataa tactgaagat gaacaaaaac aaaaccaaat aggagtgttt 2948 gtattccttt agagatctgg atatttttca aagacttgct ttttacgcac attgtgatag 3008 agcatctttt gttgactcac gtaacctcca tgtgtgggtc ctttgtttta ttagaaccat 3068 ggaagaaggt tcctgggcca tcagtatgtg ttgcagagct cacagccagg aacacttatt 3128 ttgaacaatg cagacagtac ttgccagagt cccaaatgct gaattattga accatgtttt 3188 ttttttcctt tgttgaaaaa aataaaccag ggtgatttct ataaatcacc agtttttggc 3248 attgg 3253 <210> 70 <211> 860 <212> PRT <213> Homo sapiens <400> 70 Met Ala Pro Ala Gly Cys Cys Cys Cys Cys Cys Phe Trp Gly Gly Ala 1 5 10 15 Val Ala Ala Ala Gly Ala Ala Arg Arg Val Leu Leu Leu Leu Leu Leu 20 25 30 Gly Val Leu Ser Ala Gly Leu Arg Pro Gly Ala Leu Ala Thr Glu His 35 40 45 Tyr Ser Pro Leu Ser Leu Leu Lys Gln Glu Leu Gln His Arg Gln Gln 50 55 60 Gln Glu Ala Pro Ala Gly Gly Gly Gly Cys Ser Pro Gln Ser Gly Asp 65 70 75 80 Trp Gly Asp Gln Tyr Ser Ala Glu Cys Gly Glu Ser Ser Phe Leu Asn 85 90 95 Phe His Asp Ser Asp Cys Glu Pro Lys Gly Ser Ser Pro Cys Asp Ser 100 105 110 Leu Leu Ser Leu Asn Thr Glu Lys Ile Leu Ser Gln Ala Lys Ser Ile 115 120 125 Ala Glu Gln Lys Arg Phe Pro Phe Ala Thr Asp Asn Asp Ser Thr Asn 130 135 140 Glu Glu Leu Ala Ile Ala Tyr Val Leu Ile Gly Ser Gly Leu Tyr Asp 145 150 155 160 Glu Ala Ile Arg His Phe Ser Thr Met Leu Gln Glu Glu Pro Asp Leu 165 170 175 Val Ser Ala Ile Tyr Gly Arg Gly Ile Ala Tyr Gly Lys Lys Gly Leu 180 185 190 His Asp Ile Lys Asn Ala Glu Leu Ala Leu Phe Glu Leu Ser Arg Val 195 200 205 Ile Thr Leu Glu Pro Asp Arg Pro Glu Val Phe Glu Gln Arg Ala Glu 210 215 220 Ile Leu Ser Pro Leu Gly Arg Ile Asn Glu Ala Val Asn Asp Leu Thr 225 230 235 240 Lys Ala Ile Gln Leu Gln Pro Ser Ala Arg Leu Tyr Arg His Arg Gly 245 250 255 Thr Leu Tyr Phe Ile Ser Glu Asp Tyr Ala Thr Ala His Glu Asp Phe 260 265 270 Gln Gln Ser Leu Glu Leu Asn Lys Asn Gln Pro Ile Ala Met Leu Tyr 275 280 285 Lys Gly Leu Thr Phe Phe His Arg Gly Leu Leu Lys Glu Ala Ile Glu 290 295 300 Ser Phe Lys Glu Ala Leu Lys Gln Lys Val Asp Phe Ile Asp Ala Tyr 305 310 315 320 Lys Ser Leu Gly Gln Ala Tyr Arg Glu Leu Gly Asn Phe Glu Ala Ala 325 330 335 Thr Glu Ser Phe Gln Lys Ala Leu Leu Leu Asn Gln Asn His Val Gln 340 345 350 Thr Leu Gln Leu Arg Gly Met Met Leu Tyr His His Gly Ser Leu Gln 355 360 365 Glu Ala Leu Lys Asn Phe Lys Arg Cys Leu Gln Leu Glu Pro Tyr Asn 370 375 380 Glu Val Cys Gln Tyr Met Lys Gly Leu Ser His Val Ala Met Gly Gln 385 390 395 400 Phe Tyr Glu Gly Ile Lys Ala Gln Thr Lys Val Met Leu Asn Asp Pro 405 410 415 Leu Pro Gly Gln Lys Ala Ser Pro Glu Tyr Leu Lys Val Lys Tyr Leu 420 425 430 Arg Glu Tyr Ser Arg His Leu His Ala His Leu Asp Thr Pro Leu Thr 435 440 445 Glu Tyr Asn Ile Asp Val Asp Leu Pro Gly Ser Phe Lys Asp His Trp 450 455 460 Ala Lys Asn Leu Pro Phe Leu Ile Glu Asp Tyr Glu Glu Gln Pro Gly 465 470 475 480 Leu Gln Pro His Ile Lys Asp Val Leu His Gln Asn Phe Glu Ser Tyr 485 490 495 Lys Pro Glu Val Gln Glu Leu Ile Cys Val Ala Asp Arg Leu Gly Ser 500 505 510 Leu Met Gln Tyr Glu Thr Pro Gly Phe Leu Pro Asn Lys Arg Ile His 515 520 525 Arg Ala Met Gly Leu Ala Ala Leu Glu Val Met Gln Ala Val Gln Arg 530 535 540 Thr Trp Thr Asn Ser Lys Val Arg Met Asn Gly Lys Thr Arg Leu Met 545 550 555 560 Gln Trp Arg Asp Met Phe Asp Ile Ala Val Lys Trp Arg Arg Ile Ala 565 570 575 Asp Pro Asp Gln Pro Val Leu Trp Leu Asp Gln Met Pro Ala Arg Ser 580 585 590 Leu Ser Arg Gly Phe Asn Asn His Ile Asn Leu Ile Arg Gly Gln Val 595 600 605 Ile Asn Met Arg Tyr Leu Glu Tyr Phe Glu Lys Ile Leu His Phe Ile 610 615 620 Lys Asp Arg Ile Leu Val Tyr His Gly Ala Asn Asn Pro Lys Gly Leu 625 630 635 640 Leu Glu Val Arg Glu Ala Leu Glu Lys Val His Lys Val Glu Asp Leu 645 650 655 Leu Pro Ile Met Lys Gln Phe Asn Thr Lys Thr Lys Asp Gly Phe Thr 660 665 670 Val Asn Thr Lys Val Pro Ser Leu Lys Asp Gln Gly Lys Glu Tyr Asp 675 680 685 Gly Phe Thr Ile Thr Ile Thr Gly Asp Lys Val Gly Asn Ile Leu Phe 690 695 700 Ser Val Glu Thr Gln Thr Thr Glu Glu Arg Thr Gln Leu Tyr His Ala 705 710 715 720 Glu Ile Asp Ala Leu Tyr Lys Asp Leu Thr Ala Lys Gly Lys Val Leu 725 730 735 Ile Leu Ser Ser Glu Phe Gly Glu Ala Asp Ala Val Cys Asn Leu Ile 740 745 750 Leu Ser Leu Val Tyr Tyr Phe Tyr Asn Leu Met Pro Leu Ser Arg Gly 755 760 765 Ser Ser Val Ile Ala Tyr Ser Val Ile Val Gly Ala Leu Met Ala Ser 770 775 780 Gly Lys Glu Val Ala Gly Lys Ile Pro Lys Gly Lys Leu Val Asp Phe 785 790 795 800 Glu Ala Met Thr Ala Pro Gly Ser Glu Ala Phe Ser Lys Val Ala Lys 805 810 815 Ser Trp Met Asn Leu Lys Ser Ile Ser Pro Ser Tyr Lys Thr Leu Pro 820 825 830 Ser Val Ser Glu Thr Phe Pro Thr Leu Arg Ser Met Ile Glu Val Leu 835 840 845 Asn Thr Asp Ser Ser Pro Arg Cys Leu Lys Lys Leu 850 855 860 <210> 71 <211> 2195 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (266)..(1714) <400> 71 agaggcgcgg cgtgactgag ctacggttct ggctgcgtcc cagaggcatc cggggcagta 60 aaaccgctgc gatcgcggag gcggcggcca ggccgagagg caggccgggc aggggtgtcg 120 gacgcagggc gctgggccgg gtttcggctt cggccacagg agtcatagag gctgggtggt 180 ctggcaagga cttgtgcatt tgagaactga caggtgcagc ggagacttct aagagggaaa 240 accaagcttt ttttctcaag gtgca atg aaa gcc ttc cac act ttc tgt gtt 292 Met Lys Ala Phe His Thr Phe Cys Val 1 5 gtc ctt ctg gtg ttt ggg agt gtc tct gaa gcc aag ttt gat gat ttt 340 Val Leu Leu Val Phe Gly Ser Val Ser Glu Ala Lys Phe Asp Asp Phe 10 15 20 25 gag gat gag gag gac ata gta gag tat gat gat aat gac ttc gct gaa 388 Glu Asp Glu Glu Asp Ile Val Glu Tyr Asp Asp Asn Asp Phe Ala Glu 30 35 40 ttt gag gat gtc atg gaa gac tct gtt act gaa tct cct caa cgg gtc 436 Phe Glu Asp Val Met Glu Asp Ser Val Thr Glu Ser Pro Gln Arg Val 45 50 55 ata atc act gaa gat gat gaa gat gag acc act gtg gag ttg gaa ggg 484 Ile Ile Thr Glu Asp Asp Glu Asp Glu Thr Thr Val Glu Leu Glu Gly 60 65 70 cag gat gaa aac caa gaa gga gat ttt gaa gat gca gat acc cag gag 532 Gln Asp Glu Asn Gln Glu Gly Asp Phe Glu Asp Ala Asp Thr Gln Glu 75 80 85 gga gat act gag agt gaa cca tat gat gat gaa gaa ttt gaa ggt tat 580 Gly Asp Thr Glu Ser Glu Pro Tyr Asp Asp Glu Glu Phe Glu Gly Tyr 90 95 100 105 gaa gac aaa cca gat act tct tct agc aaa aat aaa gac cca ata acg 628 Glu Asp Lys Pro Asp Thr Ser Ser Ser Lys Asn Lys Asp Pro Ile Thr 110 115 120 att gtt gat gtt cct gca cac ctc cag aac agc tgg gag agt tat tat 676 Ile Val Asp Val Pro Ala His Leu Gln Asn Ser Trp Glu Ser Tyr Tyr 125 130 135 cta gaa att ttg atg gtg act ggt ctg ctt gct tat atc atg aat tac 724 Leu Glu Ile Leu Met Val Thr Gly Leu Leu Ala Tyr Ile Met Asn Tyr 140 145 150 atc att ggg aag aat aaa aac agt cgc ctt gca cag gcc tgg ttt aac 772 Ile Ile Gly Lys Asn Lys Asn Ser Arg Leu Ala Gln Ala Trp Phe Asn 155 160 165 act cat agg gag ctt ttg gag agc aac ttt act tta gtg ggg gat gat 820 Thr His Arg Glu Leu Leu Glu Ser Asn Phe Thr Leu Val Gly Asp Asp 170 175 180 185 gga act aac aaa gaa gcc aca agc aca gga aag ttg aac cag gag aat 868 Gly Thr Asn Lys Glu Ala Thr Ser Thr Gly Lys Leu Asn Gln Glu Asn 190 195 200 gag cac atc tat aac ctg tgg tgt tct ggt cga gtg tgc tgt gag ggc 916 Glu His Ile Tyr Asn Leu Trp Cys Ser Gly Arg Val Cys Cys Glu Gly 205 210 215 atg ctt atc cag ctg agg ttc ctc aag aga caa gac tta ctg aat gtc 964 Met Leu Ile Gln Leu Arg Phe Leu Lys Arg Gln Asp Leu Leu Asn Val 220 225 230 ctg gcc cgg atg atg agg cca gtg agt gat caa gtg caa ata aaa gta 1012 Leu Ala Arg Met Met Arg Pro Val Ser Asp Gln Val Gln Ile Lys Val 235 240 245 acc atg aat gat gaa gac atg gat acc tac gta ttt gct gtt ggc aca 1060 Thr Met Asn Asp Glu Asp Met Asp Thr Tyr Val Phe Ala Val Gly Thr 250 255 260 265 cgg aaa gcc ttg gtg cga cta cag aaa gag atg cag gat ttg agt gag 1108 Arg Lys Ala Leu Val Arg Leu Gln Lys Glu Met Gln Asp Leu Ser Glu 270 275 280 ttt tgt agt gat aaa cct aag tct gga gca aag tat gga ctg ccg gac 1156 Phe Cys Ser Asp Lys Pro Lys Ser Gly Ala Lys Tyr Gly Leu Pro Asp 285 290 295 tct ttg gcc atc ctg tca gag atg gga gaa gtc aca gac gga atg atg 1204 Ser Leu Ala Ile Leu Ser Glu Met Gly Glu Val Thr Asp Gly Met Met 300 305 310 gat aca aag atg gtt cac ttt ctt aca cac tat gct gac aag att gaa 1252 Asp Thr Lys Met Val His Phe Leu Thr His Tyr Ala Asp Lys Ile Glu 315 320 325 tct gtt cat ttt tca gac cag ttc tct ggt cca aaa att atg caa gag 1300 Ser Val His Phe Ser Asp Gln Phe Ser Gly Pro Lys Ile Met Gln Glu 330 335 340 345 gaa ggt cag cct tta aag cta cct gac act aag agg aca ctg ttg ttt 1348 Glu Gly Gln Pro Leu Lys Leu Pro Asp Thr Lys Arg Thr Leu Leu Phe 350 355 360 aca ttt aat gtg cct ggc tca ggt aac act tac cca aag gat atg gag 1396 Thr Phe Asn Val Pro Gly Ser Gly Asn Thr Tyr Pro Lys Asp Met Glu 365 370 375 gca ctg cta ccc ctg atg aac atg gtg att tat tct att gat aaa gcc 1444 Ala Leu Leu Pro Leu Met Asn Met Val Ile Tyr Ser Ile Asp Lys Ala 380 385 390 aaa aag ttc cga ctc aac aga gaa ggc aaa caa aaa gca gat aag aac 1492 Lys Lys Phe Arg Leu Asn Arg Glu Gly Lys Gln Lys Ala Asp Lys Asn 395 400 405 cgt gcc cga gta gaa gag aac ttc ttg aaa ctg aca cat gtg caa aga 1540 Arg Ala Arg Val Glu Glu Asn Phe Leu Lys Leu Thr His Val Gln Arg 410 415 420 425 cag gaa gca gca cag tct cgg cgg gag gag aaa aaa aga gca gag aag 1588 Gln Glu Ala Ala Gln Ser Arg Arg Glu Glu Lys Lys Arg Ala Glu Lys 430 435 440 gag cga atc atg aat gag gaa gat cct gag aaa cag cgc agg ctg gag 1636 Glu Arg Ile Met Asn Glu Glu Asp Pro Glu Lys Gln Arg Arg Leu Glu 445 450 455 gag gct gca ttg agg cgt gag caa aag aag ttg gaa aag aag caa atg 1684 Glu Ala Ala Leu Arg Arg Glu Gln Lys Lys Leu Glu Lys Lys Gln Met 460 465 470 aaa atg aaa caa atc aaa gtg aaa gcc atg taaagccatc ccagagattt 1734 Lys Met Lys Gln Ile Lys Val Lys Ala Met 475 480 gagttctgat gccacctgta agctctgaat tcacaggaaa catgaaaaac gccagtccat 1794 ttctcaacct taaatttcag acagtcttgg gcaactgaga aatccttatt tcatcatcta 1854 ctctgtttgg ggtttggggt tttacagaga ttgaagatac ctggaaaggg ctctgtttca 1914 agaatttttt tttccagata atcaaattat tttgattatt ttataaaagg aatgatctat 1974 gaaatctgtg taggttttaa atattttaaa aattataata caaatcatca gtgcttttag 2034 tacttcagtg tttaaagaaa taccatgaaa tttataggta gataaccaga ttgttgcttt 2094 ttgtttaaac caagcagttg aaatggctat aaagactgac tctaaaccaa gattctgcaa 2154 ataatgattg gaattgcaca ataaacattg cttgatgttt t 2195 <210> 72 <211> 483 <212> PRT <213> Homo sapiens <400> 72 Met Lys Ala Phe His Thr Phe Cys Val Val Leu Leu Val Phe Gly Ser 1 5 10 15 Val Ser Glu Ala Lys Phe Asp Asp Phe Glu Asp Glu Glu Asp Ile Val 20 25 30 Glu Tyr Asp Asp Asn Asp Phe Ala Glu Phe Glu Asp Val Met Glu Asp 35 40 45 Ser Val Thr Glu Ser Pro Gln Arg Val Ile Ile Thr Glu Asp Asp Glu 50 55 60 Asp Glu Thr Thr Val Glu Leu Glu Gly Gln Asp Glu Asn Gln Glu Gly 65 70 75 80 Asp Phe Glu Asp Ala Asp Thr Gln Glu Gly Asp Thr Glu Ser Glu Pro 85 90 95 Tyr Asp Asp Glu Glu Phe Glu Gly Tyr Glu Asp Lys Pro Asp Thr Ser 100 105 110 Ser Ser Lys Asn Lys Asp Pro Ile Thr Ile Val Asp Val Pro Ala His 115 120 125 Leu Gln Asn Ser Trp Glu Ser Tyr Tyr Leu Glu Ile Leu Met Val Thr 130 135 140 Gly Leu Leu Ala Tyr Ile Met Asn Tyr Ile Ile Gly Lys Asn Lys Asn 145 150 155 160 Ser Arg Leu Ala Gln Ala Trp Phe Asn Thr His Arg Glu Leu Leu Glu 165 170 175 Ser Asn Phe Thr Leu Val Gly Asp Asp Gly Thr Asn Lys Glu Ala Thr 180 185 190 Ser Thr Gly Lys Leu Asn Gln Glu Asn Glu His Ile Tyr Asn Leu Trp 195 200 205 Cys Ser Gly Arg Val Cys Cys Glu Gly Met Leu Ile Gln Leu Arg Phe 210 215 220 Leu Lys Arg Gln Asp Leu Leu Asn Val Leu Ala Arg Met Met Arg Pro 225 230 235 240 Val Ser Asp Gln Val Gln Ile Lys Val Thr Met Asn Asp Glu Asp Met 245 250 255 Asp Thr Tyr Val Phe Ala Val Gly Thr Arg Lys Ala Leu Val Arg Leu 260 265 270 Gln Lys Glu Met Gln Asp Leu Ser Glu Phe Cys Ser Asp Lys Pro Lys 275 280 285 Ser Gly Ala Lys Tyr Gly Leu Pro Asp Ser Leu Ala Ile Leu Ser Glu 290 295 300 Met Gly Glu Val Thr Asp Gly Met Met Asp Thr Lys Met Val His Phe 305 310 315 320 Leu Thr His Tyr Ala Asp Lys Ile Glu Ser Val His Phe Ser Asp Gln 325 330 335 Phe Ser Gly Pro Lys Ile Met Gln Glu Glu Gly Gln Pro Leu Lys Leu 340 345 350 Pro Asp Thr Lys Arg Thr Leu Leu Phe Thr Phe Asn Val Pro Gly Ser 355 360 365 Gly Asn Thr Tyr Pro Lys Asp Met Glu Ala Leu Leu Pro Leu Met Asn 370 375 380 Met Val Ile Tyr Ser Ile Asp Lys Ala Lys Lys Phe Arg Leu Asn Arg 385 390 395 400 Glu Gly Lys Gln Lys Ala Asp Lys Asn Arg Ala Arg Val Glu Glu Asn 405 410 415 Phe Leu Lys Leu Thr His Val Gln Arg Gln Glu Ala Ala Gln Ser Arg 420 425 430 Arg Glu Glu Lys Lys Arg Ala Glu Lys Glu Arg Ile Met Asn Glu Glu 435 440 445 Asp Pro Glu Lys Gln Arg Arg Leu Glu Glu Ala Ala Leu Arg Arg Glu 450 455 460 Gln Lys Lys Leu Glu Lys Lys Gln Met Lys Met Lys Gln Ile Lys Val 465 470 475 480 Lys Ala Met <210> 73 <211> 1290 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (258)..(824) <400> 73 aggggacggt tgctggccca ggtgagcggg cgcgctggtc caggtgagcg ggcgcgtccc 60 cccgacggcg ctgcctgccc gaggcggttc acgtaaagac agcgagatcc tgagggccag 120 ccgggaagga ggcgtggata tggagctggc tgctgccaag tccggggccc gcgccgctgc 180 ctagcgcgtc ctggggactc tgtggggacg cgccccgcgc cgcggctcgg ggacccgtag 240 agcccggcgc tgcgcgc atg gcc ctg ctc tcg cgc ccc gcg ctc acc ctc 290 Met Ala Leu Leu Ser Arg Pro Ala Leu Thr Leu 1 5 10 ctg ctc ctc ctc atg gcc gct gtt gtc agg tgc cag gag cag gcc cag 338 Leu Leu Leu Leu Met Ala Ala Val Val Arg Cys Gln Glu Gln Ala Gln 15 20 25 acc acc gac tgg aga gcc acc ctg aag acc atc cgg aac ggc gtt cat 386 Thr Thr Asp Trp Arg Ala Thr Leu Lys Thr Ile Arg Asn Gly Val His 30 35 40 aag ata gac acg tac ctg aac gcc gcc ttg gac ctc cta gga ggc gag 434 Lys Ile Asp Thr Tyr Leu Asn Ala Ala Leu Asp Leu Leu Gly Gly Glu 45 50 55 gac ggt ctc tgc cag tat aaa tgc agt gac gga tct aag cct ttc cca 482 Asp Gly Leu Cys Gln Tyr Lys Cys Ser Asp Gly Ser Lys Pro Phe Pro 60 65 70 75 cgt tat ggt tat aaa ccc tcc cca ccg aat gga tgt ggc tct cca ctg 530 Arg Tyr Gly Tyr Lys Pro Ser Pro Pro Asn Gly Cys Gly Ser Pro Leu 80 85 90 ttt ggt gtt cat ctt aac att ggt atc cct tcc ctg aca aag tgt tgc 578 Phe Gly Val His Leu Asn Ile Gly Ile Pro Ser Leu Thr Lys Cys Cys 95 100 105 aac caa cac gac agg tgc tat gag acc tgt ggc aaa agc aag aat gac 626 Asn Gln His Asp Arg Cys Tyr Glu Thr Cys Gly Lys Ser Lys Asn Asp 110 115 120 tgt gat gaa gaa ttc cag tat tgc ctc tcc aag atc tgc cga gat gta 674 Cys Asp Glu Glu Phe Gln Tyr Cys Leu Ser Lys Ile Cys Arg Asp Val 125 130 135 cag aaa aca cta gga cta act cag cat gtt cag gca tgt gaa aca aca 722 Gln Lys Thr Leu Gly Leu Thr Gln His Val Gln Ala Cys Glu Thr Thr 140 145 150 155 gtg gag ctc ttg ttt gac agt gtt ata cat tta ggt tgt aaa cca tat 770 Val Glu Leu Leu Phe Asp Ser Val Ile His Leu Gly Cys Lys Pro Tyr 160 165 170 ctg gac agc caa cga gcc gca tgc agg tgt cat tat gaa gaa aaa act 818 Leu Asp Ser Gln Arg Ala Ala Cys Arg Cys His Tyr Glu Glu Lys Thr 175 180 185 gat ctt taaaggagat gccgacagct agtgacagat gaagatggaa gaacataacc 874 Asp Leu tttgacaaat aactaatgtt tttacaacat aaaactgtct tatttttgtg aaaggattat 934 tttgagacct taaaataatt tatatcttga tgttaaaacc tcaaagcaaa aaaagtgagg 994 gagatagtga ggggagggca cgcttgtctt ctcaggtatc ttccccagca ttgctccctt 1054 acttagtatg ccaaatgtct tgaccaatat caaaaacaag tgcttgttta gcggagaatt 1114 ttgaaaagag gaatatataa ctcaattttc acaaccacat ttaccaaaaa aagagatcaa 1174 atataaaatt catcataatg tctgttcaac attatcttat ttggaaaatg gggaaattat 1234 cacttacaag tatttgttta ctatgaaatt ttaaatacac atttatgcct agaagg 1290 <210> 74 <211> 189 <212> PRT <213> Homo sapiens <400> 74 Met Ala Leu Leu Ser Arg Pro Ala Leu Thr Leu Leu Leu Leu Leu Met 1 5 10 15 Ala Ala Val Val Arg Cys Gln Glu Gln Ala Gln Thr Thr Asp Trp Arg 20 25 30 Ala Thr Leu Lys Thr Ile Arg Asn Gly Val His Lys Ile Asp Thr Tyr 35 40 45 Leu Asn Ala Ala Leu Asp Leu Leu Gly Gly Glu Asp Gly Leu Cys Gln 50 55 60 Tyr Lys Cys Ser Asp Gly Ser Lys Pro Phe Pro Arg Tyr Gly Tyr Lys 65 70 75 80 Pro Ser Pro Pro Asn Gly Cys Gly Ser Pro Leu Phe Gly Val His Leu 85 90 95 Asn Ile Gly Ile Pro Ser Leu Thr Lys Cys Cys Asn Gln His Asp Arg 100 105 110 Cys Tyr Glu Thr Cys Gly Lys Ser Lys Asn Asp Cys Asp Glu Glu Phe 115 120 125 Gln Tyr Cys Leu Ser Lys Ile Cys Arg Asp Val Gln Lys Thr Leu Gly 130 135 140 Leu Thr Gln His Val Gln Ala Cys Glu Thr Thr Val Glu Leu Leu Phe 145 150 155 160 Asp Ser Val Ile His Leu Gly Cys Lys Pro Tyr Leu Asp Ser Gln Arg 165 170 175 Ala Ala Cys Arg Cys His Tyr Glu Glu Lys Thr Asp Leu 180 185 <210> 75 <211> 3171 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (85)..(2304) <400> 75 ctcctgccag cgcgctctct gtttctctgc agccccgaag ctcgcgaatg tagcaggcgc 60 cccaagctcg gtcctcaaga agcc atg gcg gaa tcc agg ggc cgt ctg tac 111 Met Ala Glu Ser Arg Gly Arg Leu Tyr 1 5 ctt tgg atg tgc ttg gct gct gcg ctg gca tct ttc ctg atg gga ttt 159 Leu Trp Met Cys Leu Ala Ala Ala Leu Ala Ser Phe Leu Met Gly Phe 10 15 20 25 atg gtg ggc tgg ttt att aag cct ctc aaa gaa acg acc act tct gtg 207 Met Val Gly Trp Phe Ile Lys Pro Leu Lys Glu Thr Thr Thr Ser Val 30 35 40 cgc tat cat caa agt ata cgg tgg aaa ctg gta tcc gaa atg aaa gct 255 Arg Tyr His Gln Ser Ile Arg Trp Lys Leu Val Ser Glu Met Lys Ala 45 50 55 gaa aac atc aaa tca ttt ctt cgt tct ttt aca aag ctt cct cat ctg 303 Glu Asn Ile Lys Ser Phe Leu Arg Ser Phe Thr Lys Leu Pro His Leu 60 65 70 gca gga aca gaa caa aat ttc ttg ctt gcc aag aaa atc caa acc cag 351 Ala Gly Thr Glu Gln Asn Phe Leu Leu Ala Lys Lys Ile Gln Thr Gln 75 80 85 tgg aag aaa ttt gga cta gat tca gcc aag ttg gtt cat tat gat gtc 399 Trp Lys Lys Phe Gly Leu Asp Ser Ala Lys Leu Val His Tyr Asp Val 90 95 100 105 ctc tta tct tac ccc aat gag aca aat gcc aac tat ata tcg att gtg 447 Leu Leu Ser Tyr Pro Asn Glu Thr Asn Ala Asn Tyr Ile Ser Ile Val 110 115 120 gat gaa cat gaa act gag att ttc aaa aca tca tac ctt gaa cca cca 495 Asp Glu His Glu Thr Glu Ile Phe Lys Thr Ser Tyr Leu Glu Pro Pro 125 130 135 cca gat ggc tat gag aat gtt aca aat att gtg cca cca tat aat gct 543 Pro Asp Gly Tyr Glu Asn Val Thr Asn Ile Val Pro Pro Tyr Asn Ala 140 145 150 ttc tca gcc caa ggc atg cca gag gga gat ctt gta tat gtg aac tat 591 Phe Ser Ala Gln Gly Met Pro Glu Gly Asp Leu Val Tyr Val Asn Tyr 155 160 165 gct cgc act gaa gac ttt ttc aaa cta gaa aga gag atg ggc atc aac 639 Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Glu Met Gly Ile Asn 170 175 180 185 tgt act ggg aag att gtt att gca aga tat gga aaa atc ttc aga gga 687 Cys Thr Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Ile Phe Arg Gly 190 195 200 aat aaa gtt aaa aat gcc atg tta gca gga gcc ata gga atc atc ttg 735 Asn Lys Val Lys Asn Ala Met Leu Ala Gly Ala Ile Gly Ile Ile Leu 205 210 215 tac tca gat cca gct gac tac ttt gct cct gag gta cag cca tat ccc 783 Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Glu Val Gln Pro Tyr Pro 220 225 230 aaa gga tgg aat ctt cct gga act gca gcc cag aga gga aat gtg tta 831 Lys Gly Trp Asn Leu Pro Gly Thr Ala Ala Gln Arg Gly Asn Val Leu 235 240 245 aat ttg aat ggt gct ggt gac cca ctc act cca ggc tat cca gca aaa 879 Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr Pro Ala Lys 250 255 260 265 gaa tac act ttc aga ctt gat gtt gaa gaa gga gtg gga atc ccc cga 927 Glu Tyr Thr Phe Arg Leu Asp Val Glu Glu Gly Val Gly Ile Pro Arg 270 275 280 ata cct gta cat ccc att gga tat aat gat gca gaa ata tta tta cgc 975 Ile Pro Val His Pro Ile Gly Tyr Asn Asp Ala Glu Ile Leu Leu Arg 285 290 295 tac ttg gga gga att gct cca cca gat aag agt tgg aag gga gcc ctt 1023 Tyr Leu Gly Gly Ile Ala Pro Pro Asp Lys Ser Trp Lys Gly Ala Leu 300 305 310 aat gtg agt tat agt atc gga cct ggc ttt aca ggg agt gat tct ttc 1071 Asn Val Ser Tyr Ser Ile Gly Pro Gly Phe Thr Gly Ser Asp Ser Phe 315 320 325 agg aag gtt aga atg cat gtt tat aac atc aat aaa att aca agg att 1119 Arg Lys Val Arg Met His Val Tyr Asn Ile Asn Lys Ile Thr Arg Ile 330 335 340 345 tac aat gta gtt gga act atc aga gga tct gtg gaa cct gac agg tat 1167 Tyr Asn Val Val Gly Thr Ile Arg Gly Ser Val Glu Pro Asp Arg Tyr 350 355 360 gtt att ctg gga ggt cac cgg gac tcc tgg gta ttt gga gct att gac 1215 Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Ala Ile Asp 365 370 375 cca acc agt ggg gtt gct gtt ttg caa gaa att gcc cgg agt ttt gga 1263 Pro Thr Ser Gly Val Ala Val Leu Gln Glu Ile Ala Arg Ser Phe Gly 380 385 390 aaa ctg atg agt aaa ggc tgg aga cct aga aga act atc att ttt gcc 1311 Lys Leu Met Ser Lys Gly Trp Arg Pro Arg Arg Thr Ile Ile Phe Ala 395 400 405 agc tgg gat gca gaa gaa ttt gga ctt ctg ggt tcc aca gaa tgg gct 1359 Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu Trp Ala 410 415 420 425 gag gag aat gtc aaa ata ctc cag gag aga agc att gct tat atc aac 1407 Glu Glu Asn Val Lys Ile Leu Gln Glu Arg Ser Ile Ala Tyr Ile Asn 430 435 440 tcg gat tca tct ata gaa ggc aat tat act ctc aga gtt gac tgt act 1455 Ser Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp Cys Thr 445 450 455 ccc ctt ctt tac caa tta gtg tat aaa ctg aca aaa gag atc ccc agc 1503 Pro Leu Leu Tyr Gln Leu Val Tyr Lys Leu Thr Lys Glu Ile Pro Ser 460 465 470 cct gat gat ggg ttt gag agt aaa tca ctg tat gaa agc tgg ttg gaa 1551 Pro Asp Asp Gly Phe Glu Ser Lys Ser Leu Tyr Glu Ser Trp Leu Glu 475 480 485 aaa gac cct tca cct gaa aat aaa aat ttg cct aga atc aat aag ctg 1599 Lys Asp Pro Ser Pro Glu Asn Lys Asn Leu Pro Arg Ile Asn Lys Leu 490 495 500 505 gga tct gga agt gac ttt gaa gct tat ttt cag aga ctt gga att gct 1647 Gly Ser Gly Ser Asp Phe Glu Ala Tyr Phe Gln Arg Leu Gly Ile Ala 510 515 520 tca ggc aga gcc cgt tac act aag aat aag aaa aca gat aag tac agc 1695 Ser Gly Arg Ala Arg Tyr Thr Lys Asn Lys Lys Thr Asp Lys Tyr Ser 525 530 535 agc tac cca gtg tac cac aca att tat gag aca ttt gaa ttg gta gag 1743 Ser Tyr Pro Val Tyr His Thr Ile Tyr Glu Thr Phe Glu Leu Val Glu 540 545 550 aaa ttt tat gac ccc aca ttt aaa aaa caa ctt tct gtg gct caa tta 1791 Lys Phe Tyr Asp Pro Thr Phe Lys Lys Gln Leu Ser Val Ala Gln Leu 555 560 565 cga gga gca ctg gta tat gag ctt gtg gat tct aaa atc att cct ttt 1839 Arg Gly Ala Leu Val Tyr Glu Leu Val Asp Ser Lys Ile Ile Pro Phe 570 575 580 585 aat att caa gac tat gca gaa gct ttg aaa aac tat gca gca agt atc 1887 Asn Ile Gln Asp Tyr Ala Glu Ala Leu Lys Asn Tyr Ala Ala Ser Ile 590 595 600 tat aat cta tct aag aaa cat gat caa caa ttg aca gac cat gga gta 1935 Tyr Asn Leu Ser Lys Lys His Asp Gln Gln Leu Thr Asp His Gly Val 605 610 615 tca ttt gac tcc tta ttt tct gct gtg aaa aac ttc tca gag gct gct 1983 Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Ser Glu Ala Ala 620 625 630 tca gat ttt cat aaa cga ctt ata caa gtt gat ctt aac aat ccc att 2031 Ser Asp Phe His Lys Arg Leu Ile Gln Val Asp Leu Asn Asn Pro Ile 635 640 645 gca gtg aga atg atg aat gac caa ctg atg ctc ctg gaa aga gca ttc 2079 Ala Val Arg Met Met Asn Asp Gln Leu Met Leu Leu Glu Arg Ala Phe 650 655 660 665 atc gat cct ctt ggt tta cca gga aag ctg ttc tat agg cac atc ata 2127 Ile Asp Pro Leu Gly Leu Pro Gly Lys Leu Phe Tyr Arg His Ile Ile 670 675 680 ttt gct cca agt agc cac aac aaa tat gct gga gaa tca ttt cct gga 2175 Phe Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly 685 690 695 atc tat gat gct atc ttt gat att gaa aat aaa gcc aac tct cgt ttg 2223 Ile Tyr Asp Ala Ile Phe Asp Ile Glu Asn Lys Ala Asn Ser Arg Leu 700 705 710 gcc tgg aaa gaa gta aag aaa cat att tct att gca gct ttt aca att 2271 Ala Trp Lys Glu Val Lys Lys His Ile Ser Ile Ala Ala Phe Thr Ile 715 720 725 caa gca gca gca gga act ctg aaa gaa gta tta tagaaggtct caagtggcta 2324 Gln Ala Ala Ala Gly Thr Leu Lys Glu Val Leu 730 735 740 gccattaaag gtgttgctaa aagtctgagg ataaaattca cctttctgat aacttatgaa 2384 gccagggtgt tctaaactct tttcatgtca tgttttgatt ataggctttg gtcttttcat 2444 ctgcaaagcc tttttttttt ttgctcttta aaagttaata attatattag caaagtgtta 2504 atctaatgaa gtaaaaaact cctgtgtggc agaaagtaaa agaaaattcc ctaaattata 2564 gcaaggaaca tgaattctca gacattgtga gtgtgggaat gtaaaatggt aaaatcactt 2624 ttgaaaacag tttggcagtt tcctataaag ttaaacatac acttttactt taggactcca 2684 gaattccact tctagttatt tattcaagag aaggaaaaac aatgatcaca gcaatacttg 2744 tatgcatgtt cattgcaact taaaagcgta aaaaccccaa atgtccatcc acagacgaat 2804 ggataaactg tggtatccat tacacaatag actacttact actcagcaat aaaaatgaag 2864 taactttcaa taaatgcaat attattggca gacattgttg aaggaaaaaa gccagacaaa 2924 caactacata aaatatgttt ctatttagat gaagtggcaa actaatctgt agtgttaaaa 2984 attagattag tgattgcctg ggccaagtgg caggttgggg aggatggctg caaagaagta 3044 tgaggaaact ttctccaata gatgagaatt ttccgtatct tgatctgagt ggcaaattgt 3104 aaacttaaaa tatatataaa atttattgta tgaaaattaa gcctcaataa acgtgattat 3164 aaaaaac 3171 <210> 76 <211> 740 <212> PRT <213> Homo sapiens <400> 76 Met Ala Glu Ser Arg Gly Arg Leu Tyr Leu Trp Met Cys Leu Ala Ala 1 5 10 15 Ala Leu Ala Ser Phe Leu Met Gly Phe Met Val Gly Trp Phe Ile Lys 20 25 30 Pro Leu Lys Glu Thr Thr Thr Ser Val Arg Tyr His Gln Ser Ile Arg 35 40 45 Trp Lys Leu Val Ser Glu Met Lys Ala Glu Asn Ile Lys Ser Phe Leu 50 55 60 Arg Ser Phe Thr Lys Leu Pro His Leu Ala Gly Thr Glu Gln Asn Phe 65 70 75 80 Leu Leu Ala Lys Lys Ile Gln Thr Gln Trp Lys Lys Phe Gly Leu Asp 85 90 95 Ser Ala Lys Leu Val His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Glu 100 105 110 Thr Asn Ala Asn Tyr Ile Ser Ile Val Asp Glu His Glu Thr Glu Ile 115 120 125 Phe Lys Thr Ser Tyr Leu Glu Pro Pro Pro Asp Gly Tyr Glu Asn Val 130 135 140 Thr Asn Ile Val Pro Pro Tyr Asn Ala Phe Ser Ala Gln Gly Met Pro 145 150 155 160 Glu Gly Asp Leu Val Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe 165 170 175 Lys Leu Glu Arg Glu Met Gly Ile Asn Cys Thr Gly Lys Ile Val Ile 180 185 190 Ala Arg Tyr Gly Lys Ile Phe Arg Gly Asn Lys Val Lys Asn Ala Met 195 200 205 Leu Ala Gly Ala Ile Gly Ile Ile Leu Tyr Ser Asp Pro Ala Asp Tyr 210 215 220 Phe Ala Pro Glu Val Gln Pro Tyr Pro Lys Gly Trp Asn Leu Pro Gly 225 230 235 240 Thr Ala Ala Gln Arg Gly Asn Val Leu Asn Leu Asn Gly Ala Gly Asp 245 250 255 Pro Leu Thr Pro Gly Tyr Pro Ala Lys Glu Tyr Thr Phe Arg Leu Asp 260 265 270 Val Glu Glu Gly Val Gly Ile Pro Arg Ile Pro Val His Pro Ile Gly 275 280 285 Tyr Asn Asp Ala Glu Ile Leu Leu Arg Tyr Leu Gly Gly Ile Ala Pro 290 295 300 Pro Asp Lys Ser Trp Lys Gly Ala Leu Asn Val Ser Tyr Ser Ile Gly 305 310 315 320 Pro Gly Phe Thr Gly Ser Asp Ser Phe Arg Lys Val Arg Met His Val 325 330 335 Tyr Asn Ile Asn Lys Ile Thr Arg Ile Tyr Asn Val Val Gly Thr Ile 340 345 350 Arg Gly Ser Val Glu Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg 355 360 365 Asp Ser Trp Val Phe Gly Ala Ile Asp Pro Thr Ser Gly Val Ala Val 370 375 380 Leu Gln Glu Ile Ala Arg Ser Phe Gly Lys Leu Met Ser Lys Gly Trp 385 390 395 400 Arg Pro Arg Arg Thr Ile Ile Phe Ala Ser Trp Asp Ala Glu Glu Phe 405 410 415 Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu Glu Asn Val Lys Ile Leu 420 425 430 Gln Glu Arg Ser Ile Ala Tyr Ile Asn Ser Asp Ser Ser Ile Glu Gly 435 440 445 Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Leu Tyr Gln Leu Val 450 455 460 Tyr Lys Leu Thr Lys Glu Ile Pro Ser Pro Asp Asp Gly Phe Glu Ser 465 470 475 480 Lys Ser Leu Tyr Glu Ser Trp Leu Glu Lys Asp Pro Ser Pro Glu Asn 485 490 495 Lys Asn Leu Pro Arg Ile Asn Lys Leu Gly Ser Gly Ser Asp Phe Glu 500 505 510 Ala Tyr Phe Gln Arg Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr 515 520 525 Lys Asn Lys Lys Thr Asp Lys Tyr Ser Ser Tyr Pro Val Tyr His Thr 530 535 540 Ile Tyr Glu Thr Phe Glu Leu Val Glu Lys Phe Tyr Asp Pro Thr Phe 545 550 555 560 Lys Lys Gln Leu Ser Val Ala Gln Leu Arg Gly Ala Leu Val Tyr Glu 565 570 575 Leu Val Asp Ser Lys Ile Ile Pro Phe Asn Ile Gln Asp Tyr Ala Glu 580 585 590 Ala Leu Lys Asn Tyr Ala Ala Ser Ile Tyr Asn Leu Ser Lys Lys His 595 600 605 Asp Gln Gln Leu Thr Asp His Gly Val Ser Phe Asp Ser Leu Phe Ser 610 615 620 Ala Val Lys Asn Phe Ser Glu Ala Ala Ser Asp Phe His Lys Arg Leu 625 630 635 640 Ile Gln Val Asp Leu Asn Asn Pro Ile Ala Val Arg Met Met Asn Asp 645 650 655 Gln Leu Met Leu Leu Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro 660 665 670 Gly Lys Leu Phe Tyr Arg His Ile Ile Phe Ala Pro Ser Ser His Asn 675 680 685 Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile Tyr Asp Ala Ile Phe Asp 690 695 700 Ile Glu Asn Lys Ala Asn Ser Arg Leu Ala Trp Lys Glu Val Lys Lys 705 710 715 720 His Ile Ser Ile Ala Ala Phe Thr Ile Gln Ala Ala Ala Gly Thr Leu 725 730 735 Lys Glu Val Leu 740 <210> 77 <211> 2890 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (131)..(646) <400> 77 agccgggccc cccagcggtc ggcgggacgg ctcccggctg cagtctgccc gcccgccccg 60 cgcgggggcc gagtcgcgaa gcgcgcctgc gacccggcgt ccgggcgcgc tggagaggac 120 gcgaggagcc atg agg cgc cag cct gcg aag gtg gcg gcg ctg ctg ctc 169 Met Arg Arg Gln Pro Ala Lys Val Ala Ala Leu Leu Leu 1 5 10 ggg ctg ctc ttg gag tgc aca gaa gcc aaa aag cat tgc tgg tat ttc 217 Gly Leu Leu Leu Glu Cys Thr Glu Ala Lys Lys His Cys Trp Tyr Phe 15 20 25 gaa gga ctc tat cca acc tat tat ata tgc cgc tcc tac gag gac tgc 265 Glu Gly Leu Tyr Pro Thr Tyr Tyr Ile Cys Arg Ser Tyr Glu Asp Cys 30 35 40 45 tgt ggc tcc agg tgc tgt gtg cgg gcc ctc tcc ata cag agg ctg tgg 313 Cys Gly Ser Arg Cys Cys Val Arg Ala Leu Ser Ile Gln Arg Leu Trp 50 55 60 tac ttc tgg ttc ctt ctg atg atg ggc gtg ctt ttc tgc tgc gga gcc 361 Tyr Phe Trp Phe Leu Leu Met Met Gly Val Leu Phe Cys Cys Gly Ala 65 70 75 ggc ttc ttc atc cgg agg cgc atg tac ccc ccg ccg ctg atc gag gag 409 Gly Phe Phe Ile Arg Arg Arg Met Tyr Pro Pro Pro Leu Ile Glu Glu 80 85 90 cca gcc ttc aat gtg tcc tac acc agg cag ccc cca aat ccc ggc cca 457 Pro Ala Phe Asn Val Ser Tyr Thr Arg Gln Pro Pro Asn Pro Gly Pro 95 100 105 gga acc cag cag ccg ggg ccg ccc tat tac acc gac cca gga gga ccg 505 Gly Thr Gln Gln Pro Gly Pro Pro Tyr Tyr Thr Asp Pro Gly Gly Pro 110 115 120 125 ggg atg aac cct gtc ggg aat tcc atg gca atg gct ttc cag gtc cca 553 Gly Met Asn Pro Val Gly Asn Ser Met Ala Met Ala Phe Gln Val Pro 130 135 140 ccc aac tca ccc cag ggg agt gtg gcc tgc ccg ccc cct cca gcc tac 601 Pro Asn Ser Pro Gln Gly Ser Val Ala Cys Pro Pro Pro Pro Ala Tyr 145 150 155 tgc aac acg cct ccg ccc ccg tac gaa cag gta gtg aag gcc aag 646 Cys Asn Thr Pro Pro Pro Pro Tyr Glu Gln Val Val Lys Ala Lys 160 165 170 tagtggggtg cccacgtgca agaggagaga caggagaggg cctttccctg gcctttctgt 706 cttcgttgat gttcacttcc aggaacggtc tcgtgggctg ctaagggcag ttcctctgat 766 atcctcacag caagcacagc tctctttcag gctttccatg gagtacaata tatgaactca 826 cactttgtct cctctgttgc ttctgtttct gacgcagtct gtgctctcac atggtagtgt 886 ggtgacagtc cccgagggct gacgtcctta cggtggcgtg accagatcta caggagagag 946 actgagagga agaaggcagt gctggaggtg caggtggcat gtagaggggc caggccgagc 1006 atcccaggca agcatccttc tgcccgggta ttaataggaa gccccatgcc gggcggctta 1066 gccgatgaag cagcagccga ctgagctgag cccagcaggt catctgctcc agcctgtcct 1126 ctcgtcagcc ttcctcttcc agaagctgtt ggagagacat tcaggagaga gcaagcccct 1186 tgtcatgttt ctgtctctgt tcatatccta aagatagact tctcctgcac cgccagggaa 1246 gggtagcacg tgcagctctc accgcaggat ggggcctaga atcaggcttg ccttggaggc 1306 ctgacagtga tctgacatcc actaagcaaa tttatttaaa ttcatgggaa atcacttcct 1366 gccccaaact gagacattgc attttgtgag ctcttggtct gatttggaga aaggactgtt 1426 acccattttt ttggtgtgtt tatggaagtg catgtagagc gtcctgccct ttgaaatcag 1486 actgggtgtg tgtcttccct ggacatcact gcctctccag ggcattctca ggcccggggg 1546 tctccttccc tcaggcagct ccagtggtgg gttctgaagg gtgctttcaa aacggggcac 1606 atctggctgg gaagtcacat ggactcttcc agggagagag accagctgag gcgtctctct 1666 ctgaggttgt gttgggtcta agcgggtgtg tgctgggctc caaggaggag gagcttgctg 1726 ggaaaagaca ggagaagtac tgactcaact gcactgacca tgttgtcata attagaataa 1786 agaagaagtg gtcggaaatg cacattcctg gataggaatc acagctcacc ccaggatctc 1846 acaggtagtc tcctgagtag ttgacggcta gcggggagct agttccgccg catagttata 1906 gtgttgatgt gtgaacgctg acctgtcctg tgtgctaaga gctatgcagc ttagctgagg 1966 cgcctagatt actagatgtg ctgtatcacg gggaatgagg tgggggtgct tattttttaa 2026 tgaactaatc agagcctctt gagaaattgt tactcattga actggagcat caagacatct 2086 catggaagtg gatacggagt gatttggtgt ccatgctttt cactctgagg acatttaatc 2146 ggagaacctc ctggggaatt ctgtgggaga cacttgggaa caaaacagac accctgggaa 2206 tgcagttgca agcacagatg ctgccaccag tgtctctgac caccctggtg tgactgctga 2266 ctgccagcgt ggtacctccc atgctgcagg cctccatcta aatgagacaa caaagcacaa 2326 tgttcactgt ttacaaccaa gacaactgcg tgggtccaaa cactcctctt cctccaggtc 2386 atttgttttg catttttaat gtctttattt tttgtaatga aaaagcacac taagctgccc 2446 ctggaatcgg gtgcagctga ataggcaccc aaaagtccgt gactaaattt cgtttgtctt 2506 tttgatagca aattatgtta agagacagtg atggctaggg ctcaacaatt ttgtattccc 2566 atgtttgtgt gagacagagt ttgttttccc ttgaacttgg ttagaattgt gctactgtga 2626 acgctgatcc tgcatatgga agtcccactt cggtgacatt tcctggccat tcttgtttcc 2686 attgtgtgga tggtgggttg tgcccacttc ctggagtgag acagctcctg gtgtgtagaa 2746 ttcccggagc gtccgtggtt cagagtaaac ttgaagcaga tctgtgcatg cttttcctct 2806 gcaacaattg gctcgtttct cttttttgtt ctcttttgat aggatcctgt ttcctatgtg 2866 tgcaaaataa aaataaattt gggc 2890 <210> 78 <211> 172 <212> PRT <213> Homo sapiens <400> 78 Met Arg Arg Gln Pro Ala Lys Val Ala Ala Leu Leu Leu Gly Leu Leu 1 5 10 15 Leu Glu Cys Thr Glu Ala Lys Lys His Cys Trp Tyr Phe Glu Gly Leu 20 25 30 Tyr Pro Thr Tyr Tyr Ile Cys Arg Ser Tyr Glu Asp Cys Cys Gly Ser 35 40 45 Arg Cys Cys Val Arg Ala Leu Ser Ile Gln Arg Leu Trp Tyr Phe Trp 50 55 60 Phe Leu Leu Met Met Gly Val Leu Phe Cys Cys Gly Ala Gly Phe Phe 65 70 75 80 Ile Arg Arg Arg Met Tyr Pro Pro Pro Leu Ile Glu Glu Pro Ala Phe 85 90 95 Asn Val Ser Tyr Thr Arg Gln Pro Pro Asn Pro Gly Pro Gly Thr Gln 100 105 110 Gln Pro Gly Pro Pro Tyr Tyr Thr Asp Pro Gly Gly Pro Gly Met Asn 115 120 125 Pro Val Gly Asn Ser Met Ala Met Ala Phe Gln Val Pro Pro Asn Ser 130 135 140 Pro Gln Gly Ser Val Ala Cys Pro Pro Pro Pro Ala Tyr Cys Asn Thr 145 150 155 160 Pro Pro Pro Pro Tyr Glu Gln Val Val Lys Ala Lys 165 170 <210> 79 <211> 1878 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (152)..(1144) <400> 79 agttccggac gcgggcccag ccgcgcctgc gcctccgctc gcctgtggct gcgtcgcgcg 60 ctcttcctcg gagctatcca ggcggctggt gtgcagcaag ctccgcgccg accccggacg 120 cctgacgcct gacgcctgta cccggccccg c atg agc cgc tac ctg ctg ccg 172 Met Ser Arg Tyr Leu Leu Pro 1 5 ctg tcg gcg ctg ggc acg gta gca ggc gcc gcc gtg ctg ctc aag gac 220 Leu Ser Ala Leu Gly Thr Val Ala Gly Ala Ala Val Leu Leu Lys Asp 10 15 20 tat gtc acc ggt ggg gct tgc ccc agc aag gcc acc atc cct ggg aag 268 Tyr Val Thr Gly Gly Ala Cys Pro Ser Lys Ala Thr Ile Pro Gly Lys 25 30 35 acg gtc atc gtg acg ggc gcc aac aca ggc atc ggg aag cag acc gcc 316 Thr Val Ile Val Thr Gly Ala Asn Thr Gly Ile Gly Lys Gln Thr Ala 40 45 50 55 ttg gaa ctg gcc agg aga gga ggc aac atc atc ctg gcc tgc cga gac 364 Leu Glu Leu Ala Arg Arg Gly Gly Asn Ile Ile Leu Ala Cys Arg Asp 60 65 70 atg gag aag tgt gag gcg gca gca aag gac atc cgc ggg gag acc ctc 412 Met Glu Lys Cys Glu Ala Ala Ala Lys Asp Ile Arg Gly Glu Thr Leu 75 80 85 aat cac cat gtc aac gcc cgg cac ctg gac ttg gct tcc ctc aag tct 460 Asn His His Val Asn Ala Arg His Leu Asp Leu Ala Ser Leu Lys Ser 90 95 100 atc cga gtg ttt gca gca aag atc att gaa gag gag gag cga gtg gac 508 Ile Arg Val Phe Ala Ala Lys Ile Ile Glu Glu Glu Glu Arg Val Asp 105 110 115 att cta atc aac aac gcg ggt gtg atg cgg tgc ccc cac tgg acc acc 556 Ile Leu Ile Asn Asn Ala Gly Val Met Arg Cys Pro His Trp Thr Thr 120 125 130 135 gag gac ggc ttc gag atg cag ttt ggc gtt aac cac ctg ggt cac ttt 604 Glu Asp Gly Phe Glu Met Gln Phe Gly Val Asn His Leu Gly His Phe 140 145 150 ctc ttg aca aac ttg ctg ctg gac aag ctg aaa gcc tca gcc cct tcg 652 Leu Leu Thr Asn Leu Leu Leu Asp Lys Leu Lys Ala Ser Ala Pro Ser 155 160 165 cgg atc atc aac ctc tcg tcc ctg gcc cat gtt gct ggg cac ata gac 700 Arg Ile Ile Asn Leu Ser Ser Leu Ala His Val Ala Gly His Ile Asp 170 175 180 ttt gac gac ttg aac tgg cag acg agg aag tat aac acc aaa gcc gcc 748 Phe Asp Asp Leu Asn Trp Gln Thr Arg Lys Tyr Asn Thr Lys Ala Ala 185 190 195 tac tgc cag agc aag ctc gcc atc gtc ctc ttc acc aag gag ctg agc 796 Tyr Cys Gln Ser Lys Leu Ala Ile Val Leu Phe Thr Lys Glu Leu Ser 200 205 210 215 cgg cgg ctg caa ggc tct ggt gtg act gtc aac gcc ctg cac ccc ggc 844 Arg Arg Leu Gln Gly Ser Gly Val Thr Val Asn Ala Leu His Pro Gly 220 225 230 gtg gcc agg aca gag ctg ggc aga cac acg ggc atc cat ggc tcc acc 892 Val Ala Arg Thr Glu Leu Gly Arg His Thr Gly Ile His Gly Ser Thr 235 240 245 ttc tcc agc acc aca ctc ggg ccc atc ttc tgg ctg ctg gtc aag agc 940 Phe Ser Ser Thr Thr Leu Gly Pro Ile Phe Trp Leu Leu Val Lys Ser 250 255 260 ccc gag ctg gcc gcc cag ccc agc aca tac ctg gcc gtg gcg gag gaa 988 Pro Glu Leu Ala Ala Gln Pro Ser Thr Tyr Leu Ala Val Ala Glu Glu 265 270 275 ctg gcg gat gtt tcc gga aag tac ttc gat gga ctc aaa cag aag gcc 1036 Leu Ala Asp Val Ser Gly Lys Tyr Phe Asp Gly Leu Lys Gln Lys Ala 280 285 290 295 ccg gcc ccc gag gct gag gat gag gag gtg gcc cgg agg ctt tgg gct 1084 Pro Ala Pro Glu Ala Glu Asp Glu Glu Val Ala Arg Arg Leu Trp Ala 300 305 310 gaa agt gcc cgc ctg gtg ggc tta gag gct ccc tct gtg agg gag cag 1132 Glu Ser Ala Arg Leu Val Gly Leu Glu Ala Pro Ser Val Arg Glu Gln 315 320 325 ccc ctc ccc aga taacctctgg agcagatttg aaagccagga tggcgcctcc 1184 Pro Leu Pro Arg 330 agaccgagga cagctgtccg ccatgcccgc agcttcctgg cactacctga gccgggagac 1244 ccaggactgg cggccgccat gcccgcagta ggttctaggg ggcggtgctg gccgcagtgg 1304 actggcctgc aggtgagcac tgccctgggc tctggctggt tccgtctgct ctgctgccag 1364 caggggagag gggccatctg atgcttcccc tgggaatcta aactgggaat ggccgaggag 1424 gaaggggctc cacgcacttg caggccacgt caggagagcc agcggtgcct gtcggggagg 1484 gttccaaggt gctccgtgaa gagcatgggc aagttgtctg acacttggtg gattcttggg 1544 tccctgtggg accttgtgca tgcatggtcc tctctgagcc ttggtttctt cagcagtgag 1604 atgctcagaa taactgctgt ctcccatgat ggtgtggtac agcgagctgt tgtctggcta 1664 tggcatggct gtgccggggg tgtttgctga gggcttcctg tgccagagcc cagccagaga 1724 gcaggtgcag gtgtcatcct gagttcaggc tctgcacggc atggagtggg aaccccacca 1784 gctgctgcta caggacctgg gattgcctgg gactcccacc ttcctatcaa ttctcatggt 1844 agtccaaact gcagactctc aaacttgctc attt 1878 <210> 80 <211> 331 <212> PRT <213> Homo sapiens <400> 80 Met Ser Arg Tyr Leu Leu Pro Leu Ser Ala Leu Gly Thr Val Ala Gly 1 5 10 15 Ala Ala Val Leu Leu Lys Asp Tyr Val Thr Gly Gly Ala Cys Pro Ser 20 25 30 Lys Ala Thr Ile Pro Gly Lys Thr Val Ile Val Thr Gly Ala Asn Thr 35 40 45 Gly Ile Gly Lys Gln Thr Ala Leu Glu Leu Ala Arg Arg Gly Gly Asn 50 55 60 Ile Ile Leu Ala Cys Arg Asp Met Glu Lys Cys Glu Ala Ala Ala Lys 65 70 75 80 Asp Ile Arg Gly Glu Thr Leu Asn His His Val Asn Ala Arg His Leu 85 90 95 Asp Leu Ala Ser Leu Lys Ser Ile Arg Val Phe Ala Ala Lys Ile Ile 100 105 110 Glu Glu Glu Glu Arg Val Asp Ile Leu Ile Asn Asn Ala Gly Val Met 115 120 125 Arg Cys Pro His Trp Thr Thr Glu Asp Gly Phe Glu Met Gln Phe Gly 130 135 140 Val Asn His Leu Gly His Phe Leu Leu Thr Asn Leu Leu Leu Asp Lys 145 150 155 160 Leu Lys Ala Ser Ala Pro Ser Arg Ile Ile Asn Leu Ser Ser Leu Ala 165 170 175 His Val Ala Gly His Ile Asp Phe Asp Asp Leu Asn Trp Gln Thr Arg 180 185 190 Lys Tyr Asn Thr Lys Ala Ala Tyr Cys Gln Ser Lys Leu Ala Ile Val 195 200 205 Leu Phe Thr Lys Glu Leu Ser Arg Arg Leu Gln Gly Ser Gly Val Thr 210 215 220 Val Asn Ala Leu His Pro Gly Val Ala Arg Thr Glu Leu Gly Arg His 225 230 235 240 Thr Gly Ile His Gly Ser Thr Phe Ser Ser Thr Thr Leu Gly Pro Ile 245 250 255 Phe Trp Leu Leu Val Lys Ser Pro Glu Leu Ala Ala Gln Pro Ser Thr 260 265 270 Tyr Leu Ala Val Ala Glu Glu Leu Ala Asp Val Ser Gly Lys Tyr Phe 275 280 285 Asp Gly Leu Lys Gln Lys Ala Pro Ala Pro Glu Ala Glu Asp Glu Glu 290 295 300 Val Ala Arg Arg Leu Trp Ala Glu Ser Ala Arg Leu Val Gly Leu Glu 305 310 315 320 Ala Pro Ser Val Arg Glu Gln Pro Leu Pro Arg 325 330 <210> 81 <211> 2392 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (33)..(872) <400> 81 gcgcgctccc tgtgaggtgg gcaagcggcg aa atg gcg ccc tcc ggg agt ctt 53 Met Ala Pro Ser Gly Ser Leu 1 5 gca gtt ccc ctg gca gtc ctg gtg ctg ttg ctt tgg ggt gct ccc tgg 101 Ala Val Pro Leu Ala Val Leu Val Leu Leu Leu Trp Gly Ala Pro Trp 10 15 20 acg cac ggg cgg cgg agc aac gtt cgc gtc atc acg gac gag aac tgg 149 Thr His Gly Arg Arg Ser Asn Val Arg Val Ile Thr Asp Glu Asn Trp 25 30 35 aga gaa ctg ctg gaa gga gac tgg atg ata gaa ttt tat gcc ccg tgg 197 Arg Glu Leu Leu Glu Gly Asp Trp Met Ile Glu Phe Tyr Ala Pro Trp 40 45 50 55 tgc cct gct tgt caa aat ctt caa ccg gaa tgg gaa agt ttt gct gaa 245 Cys Pro Ala Cys Gln Asn Leu Gln Pro Glu Trp Glu Ser Phe Ala Glu 60 65 70 tgg gga gaa gat ctt gag gtt aat att gcg aaa gta gat gtc aca gag 293 Trp Gly Glu Asp Leu Glu Val Asn Ile Ala Lys Val Asp Val Thr Glu 75 80 85 cag cca gga ctg agt gga cgg ttt atc ata act gct ctt cct act att 341 Gln Pro Gly Leu Ser Gly Arg Phe Ile Ile Thr Ala Leu Pro Thr Ile 90 95 100 tat cat tgt aaa gat ggt gaa ttt agg cgc tat cag ggt cca agg act 389 Tyr His Cys Lys Asp Gly Glu Phe Arg Arg Tyr Gln Gly Pro Arg Thr 105 110 115 aag aag gac ttc ata aac ttt ata agt gat aaa gag tgg aag agt att 437 Lys Lys Asp Phe Ile Asn Phe Ile Ser Asp Lys Glu Trp Lys Ser Ile 120 125 130 135 gag ccc gtt tca tca tgg ttt ggt cca ggt tct gtt ctg atg agt agt 485 Glu Pro Val Ser Ser Trp Phe Gly Pro Gly Ser Val Leu Met Ser Ser 140 145 150 atg tca gca ctc ttt cag cta tct atg tgg atc agg acg tgc cat aac 533 Met Ser Ala Leu Phe Gln Leu Ser Met Trp Ile Arg Thr Cys His Asn 155 160 165 tac ttt att gaa gac ctt gga ttg cca gcg tgg gga tca tat act gtt 581 Tyr Phe Ile Glu Asp Leu Gly Leu Pro Ala Trp Gly Ser Tyr Thr Val 170 175 180 ttt gct tta gca act ctg ttt tcc gga ctg tta tta gga ctc tgt atg 629 Phe Ala Leu Ala Thr Leu Phe Ser Gly Leu Leu Leu Gly Leu Cys Met 185 190 195 ata ttt gtg gca gat tgc ctt tgt cct tca aaa agg cgc aga cca cag 677 Ile Phe Val Ala Asp Cys Leu Cys Pro Ser Lys Arg Arg Arg Pro Gln 200 205 210 215 cca tac cca tac cct tca aaa aaa tta tta tca gaa tct gca caa cct 725 Pro Tyr Pro Tyr Pro Ser Lys Lys Leu Leu Ser Glu Ser Ala Gln Pro 220 225 230 ttg aaa aaa gtg gag gag gaa caa gag gcg gat gaa gaa gat gtt tca 773 Leu Lys Lys Val Glu Glu Glu Gln Glu Ala Asp Glu Glu Asp Val Ser 235 240 245 gaa gaa gaa gct gaa agt aaa gaa gga aca aac aaa gac ttt cca cag 821 Glu Glu Glu Ala Glu Ser Lys Glu Gly Thr Asn Lys Asp Phe Pro Gln 250 255 260 aat gcc ata aga caa cgc tct ctg ggt cca tca ttg gcc aca gat aaa 869 Asn Ala Ile Arg Gln Arg Ser Leu Gly Pro Ser Leu Ala Thr Asp Lys 265 270 275 tcc tagttaaatt ttatagttat cttaatatta tgattttgat aaaaacagaa 922 Ser 280 gattgatcat tttgtttggt ttgaagtgaa ctgtgacttt tttgaatatt gcagggttca 982 gtctagattg tcattaaatt gaagagtcta cattcagaac ataaaagcac taggtataca 1042 agtttggaat atgatttaag cacagtatga tggtttaaat agttctctaa tttttgaaaa 1102 atcgtgccaa gcaataagat ttatgtatat ttgtttaata ataacctatt tcaagtctga 1162 gttttgaaaa tttacatttc ccaagtattg cattattgag gtatttaaga agattatttt 1222 agagaaaaat atttctcatt tgatataatt tttctctgtt tcactgtgtg aaaaaaagaa 1282 gatatttccc ataaatggga agtttgccca ttgtctcaag aaatgtgtat ttcagtgaca 1342 atttcgtggt ctttttagag gtatattcca aaatttcctt gtatttttag gttatgcaac 1402 taataaaaac taccttacat taattaatta cagttttcta cacatggtaa tacaggatat 1462 gctactgatt taggaagttt ttaagttcat ggtattctct tgattccaac aaagtttgat 1522 tttctcttgt atttttctta cttactatgg gttacatttt ttatttttca aattggatga 1582 taatttcttg gaaacatttt ttatgtttta gtaaacagta tttttttgtt gtttcaaact 1642 gaagtttact gagagatcca tcaaattgaa caatctgttg taatttaaaa ttttggccac 1702 ttttttcaga ttttacatca ttcttgctga acttcaactc gaaattgttt tttttttctt 1762 tttggatgtg aaggtgaaca ttcctgattt ttgtctgatg tgaaaaagcc ttggtatttt 1822 acattttgaa aattcaaaga agcttaatat aaaagtttgc attctactca ggaaaaagca 1882 tcttcttgta tatgtcttaa atgtattttt gtcctcatat acagaaagtt cttaattgat 1942 tttacagtct gtaatgcttg atgttttaaa ataataacat ttttatattt tttaaaagac 2002 aaacttcata ttatcctgtg ttctttcctg actggtaata ttgtgtggga tttcacaggt 2062 aaaagtcagt aggatggaac attttagtgt atttttactc cttaaagagc taggatacat 2122 agttttcacc ttaaaagaag ggggaaaatc ataaatacaa tgaatcaact gaccattgcg 2182 tagtagacaa tttctgtaat gtccccttct ttctaggctc tgttgctgtg tgaatccatt 2242 agatttacag tatcgtaata tacaagtttt ctttaaagcc ctctccttta gaatttaaaa 2302 tattgtacca ttgaagagtt tggatgtgta acttgtgatg ccttagaaaa atatcctaag 2362 cacaaaataa acctttctaa ccacttcatt 2392 <210> 82 <211> 280 <212> PRT <213> Homo sapiens <400> 82 Met Ala Pro Ser Gly Ser Leu Ala Val Pro Leu Ala Val Leu Val Leu 1 5 10 15 Leu Leu Trp Gly Ala Pro Trp Thr His Gly Arg Arg Ser Asn Val Arg 20 25 30 Val Ile Thr Asp Glu Asn Trp Arg Glu Leu Leu Glu Gly Asp Trp Met 35 40 45 Ile Glu Phe Tyr Ala Pro Trp Cys Pro Ala Cys Gln Asn Leu Gln Pro 50 55 60 Glu Trp Glu Ser Phe Ala Glu Trp Gly Glu Asp Leu Glu Val Asn Ile 65 70 75 80 Ala Lys Val Asp Val Thr Glu Gln Pro Gly Leu Ser Gly Arg Phe Ile 85 90 95 Ile Thr Ala Leu Pro Thr Ile Tyr His Cys Lys Asp Gly Glu Phe Arg 100 105 110 Arg Tyr Gln Gly Pro Arg Thr Lys Lys Asp Phe Ile Asn Phe Ile Ser 115 120 125 Asp Lys Glu Trp Lys Ser Ile Glu Pro Val Ser Ser Trp Phe Gly Pro 130 135 140 Gly Ser Val Leu Met Ser Ser Met Ser Ala Leu Phe Gln Leu Ser Met 145 150 155 160 Trp Ile Arg Thr Cys His Asn Tyr Phe Ile Glu Asp Leu Gly Leu Pro 165 170 175 Ala Trp Gly Ser Tyr Thr Val Phe Ala Leu Ala Thr Leu Phe Ser Gly 180 185 190 Leu Leu Leu Gly Leu Cys Met Ile Phe Val Ala Asp Cys Leu Cys Pro 195 200 205 Ser Lys Arg Arg Arg Pro Gln Pro Tyr Pro Tyr Pro Ser Lys Lys Leu 210 215 220 Leu Ser Glu Ser Ala Gln Pro Leu Lys Lys Val Glu Glu Glu Gln Glu 225 230 235 240 Ala Asp Glu Glu Asp Val Ser Glu Glu Glu Ala Glu Ser Lys Glu Gly 245 250 255 Thr Asn Lys Asp Phe Pro Gln Asn Ala Ile Arg Gln Arg Ser Leu Gly 260 265 270 Pro Ser Leu Ala Thr Asp Lys Ser 275 280 <210> 83 <211> 1821 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (137)..(1306) <400> 83 agacttgggc tggagccgcc ctgggtgtca gcggctcggc tcccgcgcac gctccggccg 60 tcgcgcagcc tcggcacctg caggtccgtg cgtcccgcgg ctggcgcccc tgactccgtc 120 ccggccaggg agggcc atg att tcc ctc ccg ggg ccc ctg gtg acc aac ttg 172 Met Ile Ser Leu Pro Gly Pro Leu Val Thr Asn Leu 1 5 10 ctg cgg ttt ttg ttc ctg ggg ctg agt gcc ctc gcg ccc ccc tcg cgg 220 Leu Arg Phe Leu Phe Leu Gly Leu Ser Ala Leu Ala Pro Pro Ser Arg 15 20 25 gcc cag ctg caa ctg cac ttg ccc gcc aac cgg ttg cag gcg gtg gag 268 Ala Gln Leu Gln Leu His Leu Pro Ala Asn Arg Leu Gln Ala Val Glu 30 35 40 gga ggg gaa gtg gtg ctt cca gcg tgg tac acc ttg cac ggg gag gtg 316 Gly Gly Glu Val Val Leu Pro Ala Trp Tyr Thr Leu His Gly Glu Val 45 50 55 60 tct tca tcc cag cca tgg gag gtg ccc ttt gtg atg tgg ttc ttc aaa 364 Ser Ser Ser Gln Pro Trp Glu Val Pro Phe Val Met Trp Phe Phe Lys 65 70 75 cag aaa gaa aag gag gat cag gtg ttg tcc tac atc aat ggg gtc aca 412 Gln Lys Glu Lys Glu Asp Gln Val Leu Ser Tyr Ile Asn Gly Val Thr 80 85 90 aca agc aaa cct gga gta tcc ttg gtc tac tcc atg ccc tcc cgg aac 460 Thr Ser Lys Pro Gly Val Ser Leu Val Tyr Ser Met Pro Ser Arg Asn 95 100 105 ctg tcc ctg cgg ctg gag ggt ctc cag gag aaa gac tct ggc ccc tac 508 Leu Ser Leu Arg Leu Glu Gly Leu Gln Glu Lys Asp Ser Gly Pro Tyr 110 115 120 agc tgc tcc gtg aat gtg caa gac aaa caa ggc aaa tct agg ggc cac 556 Ser Cys Ser Val Asn Val Gln Asp Lys Gln Gly Lys Ser Arg Gly His 125 130 135 140 agc atc aaa acc tta gaa ctc aat gta ctg gtt cct cca gct cct cca 604 Ser Ile Lys Thr Leu Glu Leu Asn Val Leu Val Pro Pro Ala Pro Pro 145 150 155 tcc tgc cgt ctc cag ggt gtg ccc cat gtg ggg gca aac gtg acc ctg 652 Ser Cys Arg Leu Gln Gly Val Pro His Val Gly Ala Asn Val Thr Leu 160 165 170 agc tgc cag tct cca agg agt aag ccc gct gtc caa tac cag tgg gat 700 Ser Cys Gln Ser Pro Arg Ser Lys Pro Ala Val Gln Tyr Gln Trp Asp 175 180 185 cgg cag ctt cca tcc ttc cag act ttc ttt gca cca gca tta gat gtc 748 Arg Gln Leu Pro Ser Phe Gln Thr Phe Phe Ala Pro Ala Leu Asp Val 190 195 200 atc cgt ggg tct tta agc ctc acc aac ctt tcg tct tcc atg gct gga 796 Ile Arg Gly Ser Leu Ser Leu Thr Asn Leu Ser Ser Ser Met Ala Gly 205 210 215 220 gtc tat gtc tgc aag gcc cac aat gag gtg ggc act gcc caa tgt aat 844 Val Tyr Val Cys Lys Ala His Asn Glu Val Gly Thr Ala Gln Cys Asn 225 230 235 gtg acg ctg gaa gtg agc aca ggg cct gga gct gca gtg gtt gct gga 892 Val Thr Leu Glu Val Ser Thr Gly Pro Gly Ala Ala Val Val Ala Gly 240 245 250 gct gtt gtg ggt acc ctg gtt gga ctg ggg ttg ctg gct ggg ctg gtc 940 Ala Val Val Gly Thr Leu Val Gly Leu Gly Leu Leu Ala Gly Leu Val 255 260 265 ctc ttg tac cac cgc cgg ggc aag gcc ctg gag gag cca gcc aat gat 988 Leu Leu Tyr His Arg Arg Gly Lys Ala Leu Glu Glu Pro Ala Asn Asp 270 275 280 atc aag gag gat gcc att gct ccc cgg acc ctg ccc tgg ccc aag agc 1036 Ile Lys Glu Asp Ala Ile Ala Pro Arg Thr Leu Pro Trp Pro Lys Ser 285 290 295 300 tca gac aca atc tcc aag aat ggg acc ctt tcc tct gtc acc tcc gca 1084 Ser Asp Thr Ile Ser Lys Asn Gly Thr Leu Ser Ser Val Thr Ser Ala 305 310 315 cga gcc ctc cgg cca ccc cat ggc cct ccc agg cct ggt gca ttg acc 1132 Arg Ala Leu Arg Pro Pro His Gly Pro Pro Arg Pro Gly Ala Leu Thr 320 325 330 ccc acg ccc agt ctc tcc agc cag gcc ctg ccc tca cca aga ctg ccc 1180 Pro Thr Pro Ser Leu Ser Ser Gln Ala Leu Pro Ser Pro Arg Leu Pro 335 340 345 acg aca gat ggg gcc cac cct caa cca ata tcc ccc atc cct ggt ggg 1228 Thr Thr Asp Gly Ala His Pro Gln Pro Ile Ser Pro Ile Pro Gly Gly 350 355 360 gtt tct tcc tct ggc ttg agc cgc atg ggt gct gtg cct gtg atg gtg 1276 Val Ser Ser Ser Gly Leu Ser Arg Met Gly Ala Val Pro Val Met Val 365 370 375 380 cct gcc cag agt caa gct ggc tct ctg gta tgatgacccc accactcatt 1326 Pro Ala Gln Ser Gln Ala Gly Ser Leu Val 385 390 ggctaaagga tttggggtct ctccttccta taagggtcac ctctagcaca gaggcctgag 1386 tcatgggaaa gagtcacact cctgaccctt agtactctgc ccccacctct ctttactgtg 1446 ggaaaaccat ctcagtaaga cctaagtgtc caggagacag aaggagaaga ggaagtggat 1506 ctggaattgg gaggagcctc cacccacccc tgactcctcc ttatgaagcc agctgctgaa 1566 attagctact caccaagagt gaggggcaga gacttccagt cactgagtct cccaggcccc 1626 cttgatctgt accccacccc tatctaacac cacccttggc tcccactcca gctccctgta 1686 ttgatataac ctgtcaggct ggcttggtta ggttttactg gggcagagga tagggaatct 1746 cttattaaaa ctaacatgaa atatgtgttg ttttcatttg caaatttaaa taaagataca 1806 taatgtttgt atgag 1821 <210> 84 <211> 390 <212> PRT <213> Homo sapiens <400> 84 Met Ile Ser Leu Pro Gly Pro Leu Val Thr Asn Leu Leu Arg Phe Leu 1 5 10 15 Phe Leu Gly Leu Ser Ala Leu Ala Pro Pro Ser Arg Ala Gln Leu Gln 20 25 30 Leu His Leu Pro Ala Asn Arg Leu Gln Ala Val Glu Gly Gly Glu Val 35 40 45 Val Leu Pro Ala Trp Tyr Thr Leu His Gly Glu Val Ser Ser Ser Gln 50 55 60 Pro Trp Glu Val Pro Phe Val Met Trp Phe Phe Lys Gln Lys Glu Lys 65 70 75 80 Glu Asp Gln Val Leu Ser Tyr Ile Asn Gly Val Thr Thr Ser Lys Pro 85 90 95 Gly Val Ser Leu Val Tyr Ser Met Pro Ser Arg Asn Leu Ser Leu Arg 100 105 110 Leu Glu Gly Leu Gln Glu Lys Asp Ser Gly Pro Tyr Ser Cys Ser Val 115 120 125 Asn Val Gln Asp Lys Gln Gly Lys Ser Arg Gly His Ser Ile Lys Thr 130 135 140 Leu Glu Leu Asn Val Leu Val Pro Pro Ala Pro Pro Ser Cys Arg Leu 145 150 155 160 Gln Gly Val Pro His Val Gly Ala Asn Val Thr Leu Ser Cys Gln Ser 165 170 175 Pro Arg Ser Lys Pro Ala Val Gln Tyr Gln Trp Asp Arg Gln Leu Pro 180 185 190 Ser Phe Gln Thr Phe Phe Ala Pro Ala Leu Asp Val Ile Arg Gly Ser 195 200 205 Leu Ser Leu Thr Asn Leu Ser Ser Ser Met Ala Gly Val Tyr Val Cys 210 215 220 Lys Ala His Asn Glu Val Gly Thr Ala Gln Cys Asn Val Thr Leu Glu 225 230 235 240 Val Ser Thr Gly Pro Gly Ala Ala Val Val Ala Gly Ala Val Val Gly 245 250 255 Thr Leu Val Gly Leu Gly Leu Leu Ala Gly Leu Val Leu Leu Tyr His 260 265 270 Arg Arg Gly Lys Ala Leu Glu Glu Pro Ala Asn Asp Ile Lys Glu Asp 275 280 285 Ala Ile Ala Pro Arg Thr Leu Pro Trp Pro Lys Ser Ser Asp Thr Ile 290 295 300 Ser Lys Asn Gly Thr Leu Ser Ser Val Thr Ser Ala Arg Ala Leu Arg 305 310 315 320 Pro Pro His Gly Pro Pro Arg Pro Gly Ala Leu Thr Pro Thr Pro Ser 325 330 335 Leu Ser Ser Gln Ala Leu Pro Ser Pro Arg Leu Pro Thr Thr Asp Gly 340 345 350 Ala His Pro Gln Pro Ile Ser Pro Ile Pro Gly Gly Val Ser Ser Ser 355 360 365 Gly Leu Ser Arg Met Gly Ala Val Pro Val Met Val Pro Ala Gln Ser 370 375 380 Gln Ala Gly Ser Leu Val 385 390 <210> 85 <211> 1808 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (85)..(1407) <400> 85 aaactcccat ctccctcacc agccggaaag tacgagtcgg ctcagcctgg agggacccaa 60 ccagagcctg gcctgggagc cagg atg gcc atc cac aaa gcc ttg gtg atg 111 Met Ala Ile His Lys Ala Leu Val Met 1 5 tgc ctg gga ctg cct ctc ttc ctg ttc cca ggg gcc tgg gcc cag ggc 159 Cys Leu Gly Leu Pro Leu Phe Leu Phe Pro Gly Ala Trp Ala Gln Gly 10 15 20 25 cat gtc cca ccc ggc tgc agc caa ggc ctc aac ccc ctg tac tac aac 207 His Val Pro Pro Gly Cys Ser Gln Gly Leu Asn Pro Leu Tyr Tyr Asn 30 35 40 ctg tgt gac cgc tct ggg gcg tgg ggc atc gtc ctg gag gcc gtg gct 255 Leu Cys Asp Arg Ser Gly Ala Trp Gly Ile Val Leu Glu Ala Val Ala 45 50 55 ggg gcg ggc att gtc acc acg ttt gtg ctc acc atc atc ctg gtg gcc 303 Gly Ala Gly Ile Val Thr Thr Phe Val Leu Thr Ile Ile Leu Val Ala 60 65 70 agc ctc ccc ttt gtg cag gac acc aag aaa cgg agc ctg ctg ggg acc 351 Ser Leu Pro Phe Val Gln Asp Thr Lys Lys Arg Ser Leu Leu Gly Thr 75 80 85 cag gta ttc ttc ctt ctg ggg acc ctg ggc ctc ttc tgc ctc gtg ttt 399 Gln Val Phe Phe Leu Leu Gly Thr Leu Gly Leu Phe Cys Leu Val Phe 90 95 100 105 gcc tgt gtg gtg aag ccc gac ttc tcc acc tgt gcc tct cgg cgc ttc 447 Ala Cys Val Val Lys Pro Asp Phe Ser Thr Cys Ala Ser Arg Arg Phe 110 115 120 ctc ttt ggg gtt ctg ttc gcc atc tgc ttc tct tgt ctg gcg gct cac 495 Leu Phe Gly Val Leu Phe Ala Ile Cys Phe Ser Cys Leu Ala Ala His 125 130 135 gtc ttt gcc ctc aac ttc ctg gcc cgg aag aac cac ggg ccc cgg ggc 543 Val Phe Ala Leu Asn Phe Leu Ala Arg Lys Asn His Gly Pro Arg Gly 140 145 150 tgg gtg atc ttc act gtg gct ctg ctg ctg acc ctg gta gag gtc atc 591 Trp Val Ile Phe Thr Val Ala Leu Leu Leu Thr Leu Val Glu Val Ile 155 160 165 atc aat aca gag tgg ctg atc atc acc ctg gtt cgg ggc agt ggc gag 639 Ile Asn Thr Glu Trp Leu Ile Ile Thr Leu Val Arg Gly Ser Gly Glu 170 175 180 185 ggc ggc cct cag ggc aac agc agc gca ggc tgg gcc gtg gcc tcc ccc 687 Gly Gly Pro Gln Gly Asn Ser Ser Ala Gly Trp Ala Val Ala Ser Pro 190 195 200 tgt gcc atc gcc aac atg gac ttt gtc atg gca ctc atc tac gtc atg 735 Cys Ala Ile Ala Asn Met Asp Phe Val Met Ala Leu Ile Tyr Val Met 205 210 215 ctg ctg ctg ctg ggt gcc ttc ctg ggg gcc tgg ccc gcc ctg tgt ggc 783 Leu Leu Leu Leu Gly Ala Phe Leu Gly Ala Trp Pro Ala Leu Cys Gly 220 225 230 cgc tac aag cgc tgg cgt aag cat ggg gtc ttt gtg ctc ctc acc aca 831 Arg Tyr Lys Arg Trp Arg Lys His Gly Val Phe Val Leu Leu Thr Thr 235 240 245 gcc acc tcc gtt gcc ata tgg gtg gtg tgg atc gtc atg tat act tac 879 Ala Thr Ser Val Ala Ile Trp Val Val Trp Ile Val Met Tyr Thr Tyr 250 255 260 265 ggc aac aag cag cac aac agt ccc acc tgg gat gac ccc acg ctg gcc 927 Gly Asn Lys Gln His Asn Ser Pro Thr Trp Asp Asp Pro Thr Leu Ala 270 275 280 atc gcc ctc gcc gcc aat gcc tgg gcc ttc gtc ctc ttc tac gtc atc 975 Ile Ala Leu Ala Ala Asn Ala Trp Ala Phe Val Leu Phe Tyr Val Ile 285 290 295 ccc gag gtc tcc cag gtg acc aag tcc agc cca gag caa agc tac cag 1023 Pro Glu Val Ser Gln Val Thr Lys Ser Ser Pro Glu Gln Ser Tyr Gln 300 305 310 ggg gac atg tac ccc acc cgg ggc gtg ggc tat gag acc atc ctg aaa 1071 Gly Asp Met Tyr Pro Thr Arg Gly Val Gly Tyr Glu Thr Ile Leu Lys 315 320 325 gag cag aag ggt cag agc atg ttc gtg gag aac aag gcc ttt tcc atg 1119 Glu Gln Lys Gly Gln Ser Met Phe Val Glu Asn Lys Ala Phe Ser Met 330 335 340 345 gat gag ccg gtt gca gct aag agg ccg gtg tca cca tac agc ggg tac 1167 Asp Glu Pro Val Ala Ala Lys Arg Pro Val Ser Pro Tyr Ser Gly Tyr 350 355 360 aat ggg cag ctg ctg acc agt gtg tac cag ccc act gag atg gcc ctg 1215 Asn Gly Gln Leu Leu Thr Ser Val Tyr Gln Pro Thr Glu Met Ala Leu 365 370 375 atg cac aaa gtt ccg tcc gaa gga gct tac gac atc atc ctc cca cgg 1263 Met His Lys Val Pro Ser Glu Gly Ala Tyr Asp Ile Ile Leu Pro Arg 380 385 390 gcc acc gcc aac agc cag gtg atg ggc agt gcc aac tcg acc ctg cgg 1311 Ala Thr Ala Asn Ser Gln Val Met Gly Ser Ala Asn Ser Thr Leu Arg 395 400 405 gct gaa gac atg tac tcg gcc cag agc cac cag gcg gcc aca ccg ccg 1359 Ala Glu Asp Met Tyr Ser Ala Gln Ser His Gln Ala Ala Thr Pro Pro 410 415 420 425 aaa gac ggc aag aac tct cag gtc ttt aga aac ccc tac gtg tgg gac 1407 Lys Asp Gly Lys Asn Ser Gln Val Phe Arg Asn Pro Tyr Val Trp Asp 430 435 440 tgagtcagcg gtggcgagga gaggcggtcg gatttgggga gggccctgag gacctggccc 1467 gggcaaggga ctctccaggc tcctcctccc cctggcaggc ccagcaacat gtgccccaga 1527 tgtggaaggg cctccctctc tgccagtgtt tgggtgggtg tcatgggtgt ccccacccac 1587 tcctcagtgt ttgtggagtc gaggagccaa ccccagcctc ctgccaggat cacctcggcg 1647 gtcacactcc agccaaatag tgttctcggg gtggtggctg ggcagcgcct atgtttctct 1707 ggagattcct gcaacctcaa gagacttccc aggcgctcag gcctggatct tgctcctctg 1767 tgaggaacaa gggtgcctaa taaatacatt tctgctttat t 1808 <210> 86 <211> 441 <212> PRT <213> Homo sapiens <400> 86 Met Ala Ile His Lys Ala Leu Val Met Cys Leu Gly Leu Pro Leu Phe 1 5 10 15 Leu Phe Pro Gly Ala Trp Ala Gln Gly His Val Pro Pro Gly Cys Ser 20 25 30 Gln Gly Leu Asn Pro Leu Tyr Tyr Asn Leu Cys Asp Arg Ser Gly Ala 35 40 45 Trp Gly Ile Val Leu Glu Ala Val Ala Gly Ala Gly Ile Val Thr Thr 50 55 60 Phe Val Leu Thr Ile Ile Leu Val Ala Ser Leu Pro Phe Val Gln Asp 65 70 75 80 Thr Lys Lys Arg Ser Leu Leu Gly Thr Gln Val Phe Phe Leu Leu Gly 85 90 95 Thr Leu Gly Leu Phe Cys Leu Val Phe Ala Cys Val Val Lys Pro Asp 100 105 110 Phe Ser Thr Cys Ala Ser Arg Arg Phe Leu Phe Gly Val Leu Phe Ala 115 120 125 Ile Cys Phe Ser Cys Leu Ala Ala His Val Phe Ala Leu Asn Phe Leu 130 135 140 Ala Arg Lys Asn His Gly Pro Arg Gly Trp Val Ile Phe Thr Val Ala 145 150 155 160 Leu Leu Leu Thr Leu Val Glu Val Ile Ile Asn Thr Glu Trp Leu Ile 165 170 175 Ile Thr Leu Val Arg Gly Ser Gly Glu Gly Gly Pro Gln Gly Asn Ser 180 185 190 Ser Ala Gly Trp Ala Val Ala Ser Pro Cys Ala Ile Ala Asn Met Asp 195 200 205 Phe Val Met Ala Leu Ile Tyr Val Met Leu Leu Leu Leu Gly Ala Phe 210 215 220 Leu Gly Ala Trp Pro Ala Leu Cys Gly Arg Tyr Lys Arg Trp Arg Lys 225 230 235 240 His Gly Val Phe Val Leu Leu Thr Thr Ala Thr Ser Val Ala Ile Trp 245 250 255 Val Val Trp Ile Val Met Tyr Thr Tyr Gly Asn Lys Gln His Asn Ser 260 265 270 Pro Thr Trp Asp Asp Pro Thr Leu Ala Ile Ala Leu Ala Ala Asn Ala 275 280 285 Trp Ala Phe Val Leu Phe Tyr Val Ile Pro Glu Val Ser Gln Val Thr 290 295 300 Lys Ser Ser Pro Glu Gln Ser Tyr Gln Gly Asp Met Tyr Pro Thr Arg 305 310 315 320 Gly Val Gly Tyr Glu Thr Ile Leu Lys Glu Gln Lys Gly Gln Ser Met 325 330 335 Phe Val Glu Asn Lys Ala Phe Ser Met Asp Glu Pro Val Ala Ala Lys 340 345 350 Arg Pro Val Ser Pro Tyr Ser Gly Tyr Asn Gly Gln Leu Leu Thr Ser 355 360 365 Val Tyr Gln Pro Thr Glu Met Ala Leu Met His Lys Val Pro Ser Glu 370 375 380 Gly Ala Tyr Asp Ile Ile Leu Pro Arg Ala Thr Ala Asn Ser Gln Val 385 390 395 400 Met Gly Ser Ala Asn Ser Thr Leu Arg Ala Glu Asp Met Tyr Ser Ala 405 410 415 Gln Ser His Gln Ala Ala Thr Pro Pro Lys Asp Gly Lys Asn Ser Gln 420 425 430 Val Phe Arg Asn Pro Tyr Val Trp Asp 435 440 <210> 87 <211> 2015 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (100)..(1500) <400> 87 cttgactttg agcgtccggc ggtcgcagag ccaggaggcg gaggcgcgcg ggccagcctg 60 ggccccagcc cacaccttca ccagggccca ggagccacc atg tgg cga tgt cca 114 Met Trp Arg Cys Pro 1 5 ctg ggg cta ctg ctg ttg ctg ccg ctg gct ggc cac ttg gct ctg ggt 162 Leu Gly Leu Leu Leu Leu Leu Pro Leu Ala Gly His Leu Ala Leu Gly 10 15 20 gcc cag cag ggt cgt ggg cgc cgg gag cta gca ccg ggt ctg cac ctg 210 Ala Gln Gln Gly Arg Gly Arg Arg Glu Leu Ala Pro Gly Leu His Leu 25 30 35 cgg ggc atc cgg gac gcg gga ggc cgg tac tgc cag gag cag gac ctg 258 Arg Gly Ile Arg Asp Ala Gly Gly Arg Tyr Cys Gln Glu Gln Asp Leu 40 45 50 tgc tgc cgc ggc cgt gcc gac gac tgt gcc ctg ccc tac ctg ggc gcc 306 Cys Cys Arg Gly Arg Ala Asp Asp Cys Ala Leu Pro Tyr Leu Gly Ala 55 60 65 atc tgt tac tgt gac ctc ttc tgc aac cgc acg gtc tcc gac tgc tgc 354 Ile Cys Tyr Cys Asp Leu Phe Cys Asn Arg Thr Val Ser Asp Cys Cys 70 75 80 85 cct gac ttc tgg gac ttc tgc ctc ggc gtg cca ccc cct ttt ccc ccg 402 Pro Asp Phe Trp Asp Phe Cys Leu Gly Val Pro Pro Pro Phe Pro Pro 90 95 100 atc caa gga tgt atg cat gga ggt cgt atc tat cca gtc ttg gga acg 450 Ile Gln Gly Cys Met His Gly Gly Arg Ile Tyr Pro Val Leu Gly Thr 105 110 115 tac tgg gac aac tgt aac cgt tgc acc tgc cag gag aac agg cag tgg 498 Tyr Trp Asp Asn Cys Asn Arg Cys Thr Cys Gln Glu Asn Arg Gln Trp 120 125 130 cag tgt gac caa gaa cca tgc ctg gtg gat cca gac atg atc aaa gcc 546 Gln Cys Asp Gln Glu Pro Cys Leu Val Asp Pro Asp Met Ile Lys Ala 135 140 145 atc aac cag ggc aac tat ggc tgg cag gct ggg aac cac agc gcc ttc 594 Ile Asn Gln Gly Asn Tyr Gly Trp Gln Ala Gly Asn His Ser Ala Phe 150 155 160 165 tgg ggc atg acc ctg gat gag ggc att cgc tac cgc ctg ggc acc atc 642 Trp Gly Met Thr Leu Asp Glu Gly Ile Arg Tyr Arg Leu Gly Thr Ile 170 175 180 cgc cca tct tcc tcg gtc atg aac atg cat gaa att tat aca gtg ctg 690 Arg Pro Ser Ser Ser Val Met Asn Met His Glu Ile Tyr Thr Val Leu 185 190 195 aac cca ggg gag gtg ctt ccc aca gcc ttc gag gcc tct gag aag tgg 738 Asn Pro Gly Glu Val Leu Pro Thr Ala Phe Glu Ala Ser Glu Lys Trp 200 205 210 ccc aac ctg att cat gag cct ctt gac caa ggc aac tgt gca ggc tcc 786 Pro Asn Leu Ile His Glu Pro Leu Asp Gln Gly Asn Cys Ala Gly Ser 215 220 225 tgg gcc ttc tcc aca gca gct gtg gca tcc gat cgt gtc tca atc cat 834 Trp Ala Phe Ser Thr Ala Ala Val Ala Ser Asp Arg Val Ser Ile His 230 235 240 245 tct ctg gga cac atg acg cct gtc ctg tcg ccc cag aac ctg ctg tct 882 Ser Leu Gly His Met Thr Pro Val Leu Ser Pro Gln Asn Leu Leu Ser 250 255 260 tgt gac acc cac cag cag cag ggc tgc cgc ggt ggg cgt ctc gat ggt 930 Cys Asp Thr His Gln Gln Gln Gly Cys Arg Gly Gly Arg Leu Asp Gly 265 270 275 gcc tgg tgg ttc ctg cgt cgc cga ggg gtg gtg tct gac cac tgc tac 978 Ala Trp Trp Phe Leu Arg Arg Arg Gly Val Val Ser Asp His Cys Tyr 280 285 290 ccc ttc tcg ggc cgt gaa cga gac gag gct ggc cct gcg ccc ccc tgt 1026 Pro Phe Ser Gly Arg Glu Arg Asp Glu Ala Gly Pro Ala Pro Pro Cys 295 300 305 atg atg cac agc cga gcc atg ggt cgg ggc aag cgc cag gcc act gcc 1074 Met Met His Ser Arg Ala Met Gly Arg Gly Lys Arg Gln Ala Thr Ala 310 315 320 325 cac tgc ccc aac agc tat gtt aat aac aat gac atc tac cag gtc act 1122 His Cys Pro Asn Ser Tyr Val Asn Asn Asn Asp Ile Tyr Gln Val Thr 330 335 340 cct gtc tac cgc ctc ggc tcc aac gac aag gag atc atg aag gag ctg 1170 Pro Val Tyr Arg Leu Gly Ser Asn Asp Lys Glu Ile Met Lys Glu Leu 345 350 355 atg gag aat ggc cct gtc caa gcc ctc atg gag gtg cat gag gac ttc 1218 Met Glu Asn Gly Pro Val Gln Ala Leu Met Glu Val His Glu Asp Phe 360 365 370 ttc cta tac aag gga ggc atc tac agc cac acg cca gtg agc ctt ggg 1266 Phe Leu Tyr Lys Gly Gly Ile Tyr Ser His Thr Pro Val Ser Leu Gly 375 380 385 agg cca gag aga tac cgc cgg cat ggg acc cac tca gtc aag atc aca 1314 Arg Pro Glu Arg Tyr Arg Arg His Gly Thr His Ser Val Lys Ile Thr 390 395 400 405 gga tgg gga gag gag acg ctg cca gat gga agg acg ctc aaa tac tgg 1362 Gly Trp Gly Glu Glu Thr Leu Pro Asp Gly Arg Thr Leu Lys Tyr Trp 410 415 420 act gcg gcc aac tcc tgg ggc cca gcc tgg ggc gag agg ggc cac ttc 1410 Thr Ala Ala Asn Ser Trp Gly Pro Ala Trp Gly Glu Arg Gly His Phe 425 430 435 cgc atc gtg cgc ggc gtc aat gag tgc gac atc gag agc ttc gtg ctg 1458 Arg Ile Val Arg Gly Val Asn Glu Cys Asp Ile Glu Ser Phe Val Leu 440 445 450 ggc gtc tgg ggc cgc gtg ggc atg gag gac atg ggt cat cac 1500 Gly Val Trp Gly Arg Val Gly Met Glu Asp Met Gly His His 455 460 465 tgaggctgcg ggcaccacgc ggggtccggc ctgggatcca ggctaagggc cggcggaaga 1560 ggccccaatg gggcggtgac cccagcctcg cccgacagag cccggggcgc aggcgggcgc 1620 cagggcgcta atcccggcgc gggttccgct gacgcagcgc cccgcctggg agccgcgggc 1680 aggcgagact ggcggagccc ccagacctcc cagtggggac ggggcagggc ctggcctggg 1740 aagagcacag ctgcggatcc caggcctctg gcgcccccac tcaagactac aggtgcacca 1800 ccacacctgg ctaatttttg tattttttgt aaagaggggg gtctcactgt gttgcccagg 1860 ctggtctcga actcctgggc tcaagcggtc cacctgcctc cgcctcccaa agtgctggga 1920 ttgcaggcat gagccactgc acccagccct gtattcttat tcttcagata tttatttttc 1980 ttttcactgt tttaaaataa aaccaaagta ttgat 2015 <210> 88 <211> 467 <212> PRT <213> Homo sapiens <400> 88 Met Trp Arg Cys Pro Leu Gly Leu Leu Leu Leu Leu Pro Leu Ala Gly 1 5 10 15 His Leu Ala Leu Gly Ala Gln Gln Gly Arg Gly Arg Arg Glu Leu Ala 20 25 30 Pro Gly Leu His Leu Arg Gly Ile Arg Asp Ala Gly Gly Arg Tyr Cys 35 40 45 Gln Glu Gln Asp Leu Cys Cys Arg Gly Arg Ala Asp Asp Cys Ala Leu 50 55 60 Pro Tyr Leu Gly Ala Ile Cys Tyr Cys Asp Leu Phe Cys Asn Arg Thr 65 70 75 80 Val Ser Asp Cys Cys Pro Asp Phe Trp Asp Phe Cys Leu Gly Val Pro 85 90 95 Pro Pro Phe Pro Pro Ile Gln Gly Cys Met His Gly Gly Arg Ile Tyr 100 105 110 Pro Val Leu Gly Thr Tyr Trp Asp Asn Cys Asn Arg Cys Thr Cys Gln 115 120 125 Glu Asn Arg Gln Trp Gln Cys Asp Gln Glu Pro Cys Leu Val Asp Pro 130 135 140 Asp Met Ile Lys Ala Ile Asn Gln Gly Asn Tyr Gly Trp Gln Ala Gly 145 150 155 160 Asn His Ser Ala Phe Trp Gly Met Thr Leu Asp Glu Gly Ile Arg Tyr 165 170 175 Arg Leu Gly Thr Ile Arg Pro Ser Ser Ser Val Met Asn Met His Glu 180 185 190 Ile Tyr Thr Val Leu Asn Pro Gly Glu Val Leu Pro Thr Ala Phe Glu 195 200 205 Ala Ser Glu Lys Trp Pro Asn Leu Ile His Glu Pro Leu Asp Gln Gly 210 215 220 Asn Cys Ala Gly Ser Trp Ala Phe Ser Thr Ala Ala Val Ala Ser Asp 225 230 235 240 Arg Val Ser Ile His Ser Leu Gly His Met Thr Pro Val Leu Ser Pro 245 250 255 Gln Asn Leu Leu Ser Cys Asp Thr His Gln Gln Gln Gly Cys Arg Gly 260 265 270 Gly Arg Leu Asp Gly Ala Trp Trp Phe Leu Arg Arg Arg Gly Val Val 275 280 285 Ser Asp His Cys Tyr Pro Phe Ser Gly Arg Glu Arg Asp Glu Ala Gly 290 295 300 Pro Ala Pro Pro Cys Met Met His Ser Arg Ala Met Gly Arg Gly Lys 305 310 315 320 Arg Gln Ala Thr Ala His Cys Pro Asn Ser Tyr Val Asn Asn Asn Asp 325 330 335 Ile Tyr Gln Val Thr Pro Val Tyr Arg Leu Gly Ser Asn Asp Lys Glu 340 345 350 Ile Met Lys Glu Leu Met Glu Asn Gly Pro Val Gln Ala Leu Met Glu 355 360 365 Val His Glu Asp Phe Phe Leu Tyr Lys Gly Gly Ile Tyr Ser His Thr 370 375 380 Pro Val Ser Leu Gly Arg Pro Glu Arg Tyr Arg Arg His Gly Thr His 385 390 395 400 Ser Val Lys Ile Thr Gly Trp Gly Glu Glu Thr Leu Pro Asp Gly Arg 405 410 415 Thr Leu Lys Tyr Trp Thr Ala Ala Asn Ser Trp Gly Pro Ala Trp Gly 420 425 430 Glu Arg Gly His Phe Arg Ile Val Arg Gly Val Asn Glu Cys Asp Ile 435 440 445 Glu Ser Phe Val Leu Gly Val Trp Gly Arg Val Gly Met Glu Asp Met 450 455 460 Gly His His 465 <210> 89 <211> 1722 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (64)..(1692) <400> 89 gctagagctc tcgactctcc gctgcgcggc agctggcggg gggagcagcc aggtgagccc 60 aag atg ctg ctg cgc tcg aag cct gcg ctg ccg ccg ccg ctg atg ctg 108 Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu 1 5 10 15 ctg ctc ctg ggg ccg ctg ggt ccc ctc tcc cct ggc gcc ctg ccc cga 156 Leu Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg 20 25 30 cct gcg caa gca cag gac gtc gtg gac ctg gac ttc ttc acc cag gag 204 Pro Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu 35 40 45 ccg ctg cac ctg gtg agc ccc tcg ttc ctg tcc gtc acc att gac gcc 252 Pro Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala 50 55 60 aac ctg gcc acg gac ccg cgg ttc ctc atc ctc ctg ggt tct cca aag 300 Asn Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys 65 70 75 ctt cgt acc ttg gcc aga ggc ttg tct cct gcg tac ctg agg ttt ggt 348 Leu Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly 80 85 90 95 ggc acc aag aca gac ttc cta att ttc gat ccc aag aag gaa tca acc 396 Gly Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr 100 105 110 ttt gaa gag aga agt tac tgg caa tct caa gtc aac cag gat att tgc 444 Phe Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys 115 120 125 aaa tat gga tcc atc cct cct gat gtg gag gag aag tta cgg ttg gaa 492 Lys Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu 130 135 140 tgg ccc tac cag gag caa ttg cta ctc cga gaa cac tac cag aaa aag 540 Trp Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys 145 150 155 ttc aag aac agc acc tac tca aga agc tct gta gat gtg cta tac act 588 Phe Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr 160 165 170 175 ttt gca aac tgc tca gga ctg gac ttg atc ttt ggc cta aat gcg tta 636 Phe Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu 180 185 190 tta gga aca gca gat ttg cag tgg aac agt tct aat gct cag ttg ctc 684 Leu Gly Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu 195 200 205 ctg gac tac tgc tct tcc aag ggg tat aac att tct tgg gaa cta ggc 732 Leu Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly 210 215 220 aat gaa cct aac agt ttc ctt aag aag gct gat att ttc atc aat ggg 780 Asn Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly 225 230 235 tcg cag tta gga gaa gat ttt att caa ttg cat aaa ctt cta aga aag 828 Ser Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys 240 245 250 255 tcc acc ttc aaa aat gca aaa ctc tat ggt cct gat gtt ggt cag cct 876 Ser Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro 260 265 270 cga aga aag acg gct aag atg ctg aag agc ttc ctg aag gct ggt gga 924 Arg Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly 275 280 285 gaa gtg att gat tca gtt aca tgg cat cac tac tat ttg aat gga cgg 972 Glu Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg 290 295 300 act gct acc agg gaa gat ttt cta aac cct gat gta ttg gac att ttt 1020 Thr Ala Thr Arg Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe 305 310 315 att tca tct gtg caa aaa gtt ttc cag gtg gtt gag agc acc agg cct 1068 Ile Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro 320 325 330 335 ggc aag aag gtc tgg tta gga gaa aca agc tct gca cat gga ggc gga 1116 Gly Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala His Gly Gly Gly 340 345 350 gcg ccc ttg cta tcc gac acc ttt gca gct ggc ttt atg tgg ctg gat 1164 Ala Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp 355 360 365 aaa ttg ggc ctg tca gcc cga atg gga ata gaa gtg gtg atg agg caa 1212 Lys Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln 370 375 380 gta ttc ttt gga gca gga aac tac cat tta gtg gat gaa aac ttc gat 1260 Val Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp 385 390 395 cct tta cct gat tat tgg cta tct ctt ctg ttc aag aaa ttg gtg ggc 1308 Pro Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly 400 405 410 415 acc aag gtg tta atg gca agc gtg caa ggt tca aag aga agg aag ctt 1356 Thr Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu 420 425 430 cga gta tac ctt cat tgc aca aac act gac aat cca agg tat aaa gaa 1404 Arg Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu 435 440 445 gga gat tta act ctg tat gcc ata aac ctc cat aat gtc acc aag tac 1452 Gly Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr 450 455 460 ttg cgg tta ccc tat cct ttt tct aac aag caa gtg gat aaa tac ctt 1500 Leu Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu 465 470 475 cta aga cct ttg gga cct cat gga tta ctt tcc aaa tct gtc caa ctc 1548 Leu Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu 480 485 490 495 aat ggt cta act cta aag atg gtg gat gat caa acc ttg cca cct tta 1596 Asn Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu 500 505 510 atg gaa aaa cct ctc cgg cca gga agt tca ctg ggc ttg cca gct ttc 1644 Met Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe 515 520 525 tca tat agt ttt ttt gtg ata aga aat gcc aaa gtt gct gct tgc atc 1692 Ser Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 530 535 540 tgaaaataaa atatactagt cctgacactg 1722 <210> 90 <211> 543 <212> PRT <213> Homo sapiens <400> 90 Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 1 5 10 15 Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 20 25 30 Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 35 40 45 Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 50 55 60 Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 65 70 75 80 Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 85 90 95 Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 100 105 110 Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 115 120 125 Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 130 135 140 Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 145 150 155 160 Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 165 170 175 Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 180 185 190 Gly Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 195 200 205 Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 210 215 220 Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 225 230 235 240 Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 245 250 255 Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 260 265 270 Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 275 280 285 Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 290 295 300 Ala Thr Arg Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 305 310 315 320 Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 325 330 335 Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala His Gly Gly Gly Ala 340 345 350 Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys 355 360 365 Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val 370 375 380 Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro 385 390 395 400 Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr 405 410 415 Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg 420 425 430 Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly 435 440 445 Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu 450 455 460 Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu 465 470 475 480 Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn 485 490 495 Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met 500 505 510 Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser 515 520 525 Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 530 535 540 <210> 91 <211> 2291 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (46)..(1737) <400> 91 ctccatctca gagcctctcc tcaatctcaa gcctccactc ccctc atg ccc agg cac 57 Met Pro Arg His 1 tcc acg gct gtg aag atg gcg gcg gct gcg tgg ctt cag gtg ttg cct 105 Ser Thr Ala Val Lys Met Ala Ala Ala Ala Trp Leu Gln Val Leu Pro 5 10 15 20 gtc att ctt ctg ctt ctg gga gct cac ccg tca cca ctg tcg ttt ttc 153 Val Ile Leu Leu Leu Leu Gly Ala His Pro Ser Pro Leu Ser Phe Phe 25 30 35 agt gcg gga ccg gca acc gta gct gct gcc gac cgg tcc aaa tgg cac 201 Ser Ala Gly Pro Ala Thr Val Ala Ala Ala Asp Arg Ser Lys Trp His 40 45 50 att ccg ata ccg tcg ggg aaa aat tat ttt agt ttt gga aag atc ctc 249 Ile Pro Ile Pro Ser Gly Lys Asn Tyr Phe Ser Phe Gly Lys Ile Leu 55 60 65 ttc aga aat acc act atc ttc ctg aag ttt gat gga gaa cct tgt gac 297 Phe Arg Asn Thr Thr Ile Phe Leu Lys Phe Asp Gly Glu Pro Cys Asp 70 75 80 ctg tct ttg aat ata acc tgg tat ctg aaa agc gct gat tgt tac aat 345 Leu Ser Leu Asn Ile Thr Trp Tyr Leu Lys Ser Ala Asp Cys Tyr Asn 85 90 95 100 gaa atc tat aac ttc aag gca gaa gaa gta gag ttg tat ttg gaa aaa 393 Glu Ile Tyr Asn Phe Lys Ala Glu Glu Val Glu Leu Tyr Leu Glu Lys 105 110 115 ctt aag gaa aaa aga ggc ttg tct ggg aaa tat caa aca tca tca aaa 441 Leu Lys Glu Lys Arg Gly Leu Ser Gly Lys Tyr Gln Thr Ser Ser Lys 120 125 130 ttg ttc cag aac tgc agt gaa ctc ttt aaa aca cag acc ttt tct gga 489 Leu Phe Gln Asn Cys Ser Glu Leu Phe Lys Thr Gln Thr Phe Ser Gly 135 140 145 gat ttt atg cat cga ctg cct ctt tta gga gaa aaa cag gag gct aag 537 Asp Phe Met His Arg Leu Pro Leu Leu Gly Glu Lys Gln Glu Ala Lys 150 155 160 gag aat gga aca aac ctt acc ttt att gga gac aaa acc gca atg cat 585 Glu Asn Gly Thr Asn Leu Thr Phe Ile Gly Asp Lys Thr Ala Met His 165 170 175 180 gaa cca ttg caa act tgg caa gat gca cca tac att ttt att gta cat 633 Glu Pro Leu Gln Thr Trp Gln Asp Ala Pro Tyr Ile Phe Ile Val His 185 190 195 att ggc att tca tcc tca aag gaa tca tca aaa gaa aat tca ctg agt 681 Ile Gly Ile Ser Ser Ser Lys Glu Ser Ser Lys Glu Asn Ser Leu Ser 200 205 210 aat ctt ttt acc atg act gtt gaa gtg aag ggt ccc tat gaa tac ctc 729 Asn Leu Phe Thr Met Thr Val Glu Val Lys Gly Pro Tyr Glu Tyr Leu 215 220 225 aca ctt gaa gac tat ccc ttg atg att ttt ttc atg gtg atg tgt att 777 Thr Leu Glu Asp Tyr Pro Leu Met Ile Phe Phe Met Val Met Cys Ile 230 235 240 gta tat gtc ctg ttt ggt gtt ctg tgg ctg gca tgg tct gcc tgc tac 825 Val Tyr Val Leu Phe Gly Val Leu Trp Leu Ala Trp Ser Ala Cys Tyr 245 250 255 260 tgg aga gat ctc ctg aga att cag ttt tgg att ggt gct gtc atc ttc 873 Trp Arg Asp Leu Leu Arg Ile Gln Phe Trp Ile Gly Ala Val Ile Phe 265 270 275 ctg gga atg ctt gag aaa gct gtc ttc tat gcg gaa ttt cag aat atc 921 Leu Gly Met Leu Glu Lys Ala Val Phe Tyr Ala Glu Phe Gln Asn Ile 280 285 290 cga tac aaa gga gaa tct gtc cag ggt gct ttg atc ctt gca gag ctg 969 Arg Tyr Lys Gly Glu Ser Val Gln Gly Ala Leu Ile Leu Ala Glu Leu 295 300 305 ctt tca gca gtg aaa cgc tca ctg gct cga acc ctg gtc atc ata gtc 1017 Leu Ser Ala Val Lys Arg Ser Leu Ala Arg Thr Leu Val Ile Ile Val 310 315 320 agt ctg gga tat ggc atc gtc aag cca cgc ctt gga gtc act ctt cat 1065 Ser Leu Gly Tyr Gly Ile Val Lys Pro Arg Leu Gly Val Thr Leu His 325 330 335 340 aag gtt gta gta gca gga gcc ctc tat ctt ttg ttc tct ggc atg gaa 1113 Lys Val Val Val Ala Gly Ala Leu Tyr Leu Leu Phe Ser Gly Met Glu 345 350 355 ggg gtc ctc aga gtt act ggg gcc cag act gat ctt gct tcc ttg gcc 1161 Gly Val Leu Arg Val Thr Gly Ala Gln Thr Asp Leu Ala Ser Leu Ala 360 365 370 ttt atc ccc ttg gct ttc cta gac act gcc ttg tgc tgg tgg ata ttt 1209 Phe Ile Pro Leu Ala Phe Leu Asp Thr Ala Leu Cys Trp Trp Ile Phe 375 380 385 att agc ctg act caa aca atg aag cta tta aaa ctt cgg agg aac att 1257 Ile Ser Leu Thr Gln Thr Met Lys Leu Leu Lys Leu Arg Arg Asn Ile 390 395 400 gta aaa ctc tct ttg tat cgg cat ttc acc aac acg ctt att ttg gca 1305 Val Lys Leu Ser Leu Tyr Arg His Phe Thr Asn Thr Leu Ile Leu Ala 405 410 415 420 gtg gca gca tcc att gtg ttt atc atc tgg aca acc atg aag ttc aga 1353 Val Ala Ala Ser Ile Val Phe Ile Ile Trp Thr Thr Met Lys Phe Arg 425 430 435 ata gtg aca tgt cag tcg gac tgg cgg gag ctg tgg gta gac gat gcc 1401 Ile Val Thr Cys Gln Ser Asp Trp Arg Glu Leu Trp Val Asp Asp Ala 440 445 450 atc tgg cgc ttg ctg ttc tcc atg atc ctc ttt gtc atc atg gtt ctc 1449 Ile Trp Arg Leu Leu Phe Ser Met Ile Leu Phe Val Ile Met Val Leu 455 460 465 tgg cga cca tct gca aac aac cag agg ttt gcc ttt tca cca ttg tct 1497 Trp Arg Pro Ser Ala Asn Asn Gln Arg Phe Ala Phe Ser Pro Leu Ser 470 475 480 gag gaa gag gag gag gat gaa caa aag gag cct atg ctg aaa gaa agc 1545 Glu Glu Glu Glu Glu Asp Glu Gln Lys Glu Pro Met Leu Lys Glu Ser 485 490 495 500 ttt gaa gga atg aaa atg aga agt acc aaa caa gaa ccc aat gga aat 1593 Phe Glu Gly Met Lys Met Arg Ser Thr Lys Gln Glu Pro Asn Gly Asn 505 510 515 agt aaa gtt aac aaa gca cag gaa gat gat tcg aag tgg gta gaa gag 1641 Ser Lys Val Asn Lys Ala Gln Glu Asp Asp Ser Lys Trp Val Glu Glu 520 525 530 aat gtt cct tct tct gtg aca gat gta gca ctt cca gcc ctt ctg gat 1689 Asn Val Pro Ser Ser Val Thr Asp Val Ala Leu Pro Ala Leu Leu Asp 535 540 545 tca gat gag gaa cga atg atc aca cac ttt gaa agg tcc aaa atg gag 1737 Ser Asp Glu Glu Arg Met Ile Thr His Phe Glu Arg Ser Lys Met Glu 550 555 560 taaggaatgg gaagatttgc agttaaagat ggctaccatc agggaagaga tcagcatctg 1797 tgtcagtctt ctgtacggct ccatgggatt aaaggaagca atgacatcct gatctgttcc 1857 ttgatctttg ggcattggag ttggcgagag gtgtcagaac aaagagaaca tcttactgaa 1917 aacaagttca taagatgaga aaaatctacg agcttcttat ttacaacact gctgccccct 1977 ttcctcccag actctgacat ggatgttcat gcaacttaag tgtgttgttc ctgaactttc 2037 tgtaatgttt cattttttaa atctgacaaa ctaaaaagtt taacgtcttc taaaagattg 2097 tcatcaacac cataatatgt aatctccagg agcaactgcc tgtaattttt atttatttag 2157 ggagttacat aggtgatggg ggaaattgtt aactaccttt cattttcctg ggaagtcaag 2217 gttacatctt gcagaggttg ttttgagaaa aaagggccct tctgagttaa ggagccatag 2277 ttctatcaat gatc 2291 <210> 92 <211> 564 <212> PRT <213> Homo sapiens <400> 92 Met Pro Arg His Ser Thr Ala Val Lys Met Ala Ala Ala Ala Trp Leu 1 5 10 15 Gln Val Leu Pro Val Ile Leu Leu Leu Leu Gly Ala His Pro Ser Pro 20 25 30 Leu Ser Phe Phe Ser Ala Gly Pro Ala Thr Val Ala Ala Ala Asp Arg 35 40 45 Ser Lys Trp His Ile Pro Ile Pro Ser Gly Lys Asn Tyr Phe Ser Phe 50 55 60 Gly Lys Ile Leu Phe Arg Asn Thr Thr Ile Phe Leu Lys Phe Asp Gly 65 70 75 80 Glu Pro Cys Asp Leu Ser Leu Asn Ile Thr Trp Tyr Leu Lys Ser Ala 85 90 95 Asp Cys Tyr Asn Glu Ile Tyr Asn Phe Lys Ala Glu Glu Val Glu Leu 100 105 110 Tyr Leu Glu Lys Leu Lys Glu Lys Arg Gly Leu Ser Gly Lys Tyr Gln 115 120 125 Thr Ser Ser Lys Leu Phe Gln Asn Cys Ser Glu Leu Phe Lys Thr Gln 130 135 140 Thr Phe Ser Gly Asp Phe Met His Arg Leu Pro Leu Leu Gly Glu Lys 145 150 155 160 Gln Glu Ala Lys Glu Asn Gly Thr Asn Leu Thr Phe Ile Gly Asp Lys 165 170 175 Thr Ala Met His Glu Pro Leu Gln Thr Trp Gln Asp Ala Pro Tyr Ile 180 185 190 Phe Ile Val His Ile Gly Ile Ser Ser Ser Lys Glu Ser Ser Lys Glu 195 200 205 Asn Ser Leu Ser Asn Leu Phe Thr Met Thr Val Glu Val Lys Gly Pro 210 215 220 Tyr Glu Tyr Leu Thr Leu Glu Asp Tyr Pro Leu Met Ile Phe Phe Met 225 230 235 240 Val Met Cys Ile Val Tyr Val Leu Phe Gly Val Leu Trp Leu Ala Trp 245 250 255 Ser Ala Cys Tyr Trp Arg Asp Leu Leu Arg Ile Gln Phe Trp Ile Gly 260 265 270 Ala Val Ile Phe Leu Gly Met Leu Glu Lys Ala Val Phe Tyr Ala Glu 275 280 285 Phe Gln Asn Ile Arg Tyr Lys Gly Glu Ser Val Gln Gly Ala Leu Ile 290 295 300 Leu Ala Glu Leu Leu Ser Ala Val Lys Arg Ser Leu Ala Arg Thr Leu 305 310 315 320 Val Ile Ile Val Ser Leu Gly Tyr Gly Ile Val Lys Pro Arg Leu Gly 325 330 335 Val Thr Leu His Lys Val Val Val Ala Gly Ala Leu Tyr Leu Leu Phe 340 345 350 Ser Gly Met Glu Gly Val Leu Arg Val Thr Gly Ala Gln Thr Asp Leu 355 360 365 Ala Ser Leu Ala Phe Ile Pro Leu Ala Phe Leu Asp Thr Ala Leu Cys 370 375 380 Trp Trp Ile Phe Ile Ser Leu Thr Gln Thr Met Lys Leu Leu Lys Leu 385 390 395 400 Arg Arg Asn Ile Val Lys Leu Ser Leu Tyr Arg His Phe Thr Asn Thr 405 410 415 Leu Ile Leu Ala Val Ala Ala Ser Ile Val Phe Ile Ile Trp Thr Thr 420 425 430 Met Lys Phe Arg Ile Val Thr Cys Gln Ser Asp Trp Arg Glu Leu Trp 435 440 445 Val Asp Asp Ala Ile Trp Arg Leu Leu Phe Ser Met Ile Leu Phe Val 450 455 460 Ile Met Val Leu Trp Arg Pro Ser Ala Asn Asn Gln Arg Phe Ala Phe 465 470 475 480 Ser Pro Leu Ser Glu Glu Glu Glu Glu Asp Glu Gln Lys Glu Pro Met 485 490 495 Leu Lys Glu Ser Phe Glu Gly Met Lys Met Arg Ser Thr Lys Gln Glu 500 505 510 Pro Asn Gly Asn Ser Lys Val Asn Lys Ala Gln Glu Asp Asp Ser Lys 515 520 525 Trp Val Glu Glu Asn Val Pro Ser Ser Val Thr Asp Val Ala Leu Pro 530 535 540 Ala Leu Leu Asp Ser Asp Glu Glu Arg Met Ile Thr His Phe Glu Arg 545 550 555 560 Ser Lys Met Glu <210> 93 <211> 2080 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (196)..(1242) <400> 93 ctcgacgggc aagcggcgat aagaggtggc gtcctccgcg gcattgcgag caccgccagt 60 ctgcgccgcc aggcgtaggc ggggtggccc ttgcgtctcc cgcttccttg aaaaacccgg 120 cgggcgagcg aggctgcggg ccggccgctg cccttcccca cactccccgc cgagaagcct 180 cgctcggcgc ccaac atg gcg ggt ggg cgc tgc ggc ccg cag cta acg gcg 231 Met Ala Gly Gly Arg Cys Gly Pro Gln Leu Thr Ala 1 5 10 ctc ctg gcc gcc tgg atc gcg gct gtg gcg gcg acg gca ggc ccc gag 279 Leu Leu Ala Ala Trp Ile Ala Ala Val Ala Ala Thr Ala Gly Pro Glu 15 20 25 gag gcc gcg ctg ccg ccg gag cag agc cgg gtc cag ccc atg acc gcc 327 Glu Ala Ala Leu Pro Pro Glu Gln Ser Arg Val Gln Pro Met Thr Ala 30 35 40 tcc aac tgg acg ctg gtg atg gag ggc gag tgg atg ctg aaa ttt tac 375 Ser Asn Trp Thr Leu Val Met Glu Gly Glu Trp Met Leu Lys Phe Tyr 45 50 55 60 gcc cca tgg tgt cca tcc tgc cag cag act gat tca gaa tgg gag gct 423 Ala Pro Trp Cys Pro Ser Cys Gln Gln Thr Asp Ser Glu Trp Glu Ala 65 70 75 ttt gca aag aat ggt gaa ata ctt cag atc agt gtg ggg aag gta gat 471 Phe Ala Lys Asn Gly Glu Ile Leu Gln Ile Ser Val Gly Lys Val Asp 80 85 90 gtc att caa gaa cca ggt ttg agt ggc cgc ttc ttt gtc acc act ctc 519 Val Ile Gln Glu Pro Gly Leu Ser Gly Arg Phe Phe Val Thr Thr Leu 95 100 105 cca gca ttt ttt cat gca aag gat ggg ata ttc cgc cgt tat cgt ggc 567 Pro Ala Phe Phe His Ala Lys Asp Gly Ile Phe Arg Arg Tyr Arg Gly 110 115 120 cca gga atc ttc gaa gac ctg cag aat tat atc tta gag aag aaa tgg 615 Pro Gly Ile Phe Glu Asp Leu Gln Asn Tyr Ile Leu Glu Lys Lys Trp 125 130 135 140 caa tca gtc gag cct ctg act ggc tgg aaa tcc cca gct tct cta acg 663 Gln Ser Val Glu Pro Leu Thr Gly Trp Lys Ser Pro Ala Ser Leu Thr 145 150 155 atg tct gga atg gct ggt ctt ttt agc atc tct ggc aag ata tgg cat 711 Met Ser Gly Met Ala Gly Leu Phe Ser Ile Ser Gly Lys Ile Trp His 160 165 170 ctt cac aac tat ttc aca gtg act ctt gga att cct gct tgg tgt tct 759 Leu His Asn Tyr Phe Thr Val Thr Leu Gly Ile Pro Ala Trp Cys Ser 175 180 185 tat gtg ttt ttc gtc ata gcc acc ttg gtt ttt ggc ctt ttt atg ggt 807 Tyr Val Phe Phe Val Ile Ala Thr Leu Val Phe Gly Leu Phe Met Gly 190 195 200 ctg gtc ttg gtg gta ata tca gaa tgt ttc tat gtg cca ctt cca agg 855 Leu Val Leu Val Val Ile Ser Glu Cys Phe Tyr Val Pro Leu Pro Arg 205 210 215 220 cat tta tct gag cgt tct gag cag aat cgg aga tca gag gag gct cat 903 His Leu Ser Glu Arg Ser Glu Gln Asn Arg Arg Ser Glu Glu Ala His 225 230 235 aga gct gaa cag ttg cag gat gcg gag gag gaa aaa gat gat tca aat 951 Arg Ala Glu Gln Leu Gln Asp Ala Glu Glu Glu Lys Asp Asp Ser Asn 240 245 250 gaa gaa gaa aac aaa gac agc ctt gta gat gat gaa gaa gag aaa gaa 999 Glu Glu Glu Asn Lys Asp Ser Leu Val Asp Asp Glu Glu Glu Lys Glu 255 260 265 gat ctt ggc gat gag gat gaa gca gag gaa gaa gag gag gag gac aac 1047 Asp Leu Gly Asp Glu Asp Glu Ala Glu Glu Glu Glu Glu Glu Asp Asn 270 275 280 ttg gct gct ggt gtg gat gag gag aga agt gag gcc aat gat cag ggg 1095 Leu Ala Ala Gly Val Asp Glu Glu Arg Ser Glu Ala Asn Asp Gln Gly 285 290 295 300 ccc cca gga gag gac ggt gtg acc cgg gag gaa gta gag cct gag gag 1143 Pro Pro Gly Glu Asp Gly Val Thr Arg Glu Glu Val Glu Pro Glu Glu 305 310 315 gct gaa gaa ggc atc tct gag caa ccc tgc cca gct gac aca gag gtg 1191 Ala Glu Glu Gly Ile Ser Glu Gln Pro Cys Pro Ala Asp Thr Glu Val 320 325 330 gtg gaa gac tcc ttg agg cag cgt aaa agt cag cat gct gac aag gga 1239 Val Glu Asp Ser Leu Arg Gln Arg Lys Ser Gln His Ala Asp Lys Gly 335 340 345 ctg tagatttaat gatgcgtttt caagaataca caccaaaaca atatgtcagc 1292 Leu ttccctttgg cctgcagttt gtaccaaatc cttaattttt cctgaatgag caagcttctc 1352 ttaaaagatg ctctctagtc atttggtctc atggcagtaa gcctcatgta tactaaggag 1412 agtcttccag gtgtgacaat caggatatag aaaaacaaac gtagtgttgg gatctgtttg 1472 gagactggga tgggaacaag ttcatttact taggggtcag agagtctcga ccagaggagg 1532 ccattcccag tcctaatcag caccttccag agacaaggct gcaggccctg tgaaatgaaa 1592 gccaagcagg agccttggct cctgagcatc cccaaagtgt aacgtagaag ccttgcatcc 1652 ttttcttgtg taaagtattt atttttgtca aattgcagga aacatcaggc accacagtgc 1712 atgaaaaatc tttcacagct agaaattgaa agggccttgg gtatagagag cagctcagaa 1772 gtcatcccag ccctctgaat ctcctgtgct atgttttatt tcttaccttt aatttttcca 1832 gcatttccac catgggcatt caggctctcc acactcttca ctattatctc ttggtcagag 1892 gactccaata acagccaggt ttacatgaac tgtgtttgtt cattctgacc taaggggttt 1952 agataatcag taaccataac ccctgaagct gtgactgcca aacatctcaa atgaaatgtt 2012 gtggccatca gagactcaaa aggaagtaag gattttacaa gacagattaa aaaaaaattg 2072 ttttgtcc 2080 <210> 94 <211> 349 <212> PRT <213> Homo sapiens <400> 94 Met Ala Gly Gly Arg Cys Gly Pro Gln Leu Thr Ala Leu Leu Ala Ala 1 5 10 15 Trp Ile Ala Ala Val Ala Ala Thr Ala Gly Pro Glu Glu Ala Ala Leu 20 25 30 Pro Pro Glu Gln Ser Arg Val Gln Pro Met Thr Ala Ser Asn Trp Thr 35 40 45 Leu Val Met Glu Gly Glu Trp Met Leu Lys Phe Tyr Ala Pro Trp Cys 50 55 60 Pro Ser Cys Gln Gln Thr Asp Ser Glu Trp Glu Ala Phe Ala Lys Asn 65 70 75 80 Gly Glu Ile Leu Gln Ile Ser Val Gly Lys Val Asp Val Ile Gln Glu 85 90 95 Pro Gly Leu Ser Gly Arg Phe Phe Val Thr Thr Leu Pro Ala Phe Phe 100 105 110 His Ala Lys Asp Gly Ile Phe Arg Arg Tyr Arg Gly Pro Gly Ile Phe 115 120 125 Glu Asp Leu Gln Asn Tyr Ile Leu Glu Lys Lys Trp Gln Ser Val Glu 130 135 140 Pro Leu Thr Gly Trp Lys Ser Pro Ala Ser Leu Thr Met Ser Gly Met 145 150 155 160 Ala Gly Leu Phe Ser Ile Ser Gly Lys Ile Trp His Leu His Asn Tyr 165 170 175 Phe Thr Val Thr Leu Gly Ile Pro Ala Trp Cys Ser Tyr Val Phe Phe 180 185 190 Val Ile Ala Thr Leu Val Phe Gly Leu Phe Met Gly Leu Val Leu Val 195 200 205 Val Ile Ser Glu Cys Phe Tyr Val Pro Leu Pro Arg His Leu Ser Glu 210 215 220 Arg Ser Glu Gln Asn Arg Arg Ser Glu Glu Ala His Arg Ala Glu Gln 225 230 235 240 Leu Gln Asp Ala Glu Glu Glu Lys Asp Asp Ser Asn Glu Glu Glu Asn 245 250 255 Lys Asp Ser Leu Val Asp Asp Glu Glu Glu Lys Glu Asp Leu Gly Asp 260 265 270 Glu Asp Glu Ala Glu Glu Glu Glu Glu Glu Asp Asn Leu Ala Ala Gly 275 280 285 Val Asp Glu Glu Arg Ser Glu Ala Asn Asp Gln Gly Pro Pro Gly Glu 290 295 300 Asp Gly Val Thr Arg Glu Glu Val Glu Pro Glu Glu Ala Glu Glu Gly 305 310 315 320 Ile Ser Glu Gln Pro Cys Pro Ala Asp Thr Glu Val Val Glu Asp Ser 325 330 335 Leu Arg Gln Arg Lys Ser Gln His Ala Asp Lys Gly Leu 340 345 <210> 95 <211> 2185 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (73)..(696) <400> 95 accgtaacca gcgccgcgga caccggcacc ggcgccacgg actccgcaga ccccgcgccc 60 gccgccgccg ct atg ctg ggg ctg ctg gtg gcg ttg ctg gcc ctg ggg ctc 111 Met Leu Gly Leu Leu Val Ala Leu Leu Ala Leu Gly Leu 1 5 10 gct gtc ttt gcg ctg ctg ggc gtc tgg tac ctg gtg cgc ctt ccg tgc 159 Ala Val Phe Ala Leu Leu Gly Val Trp Tyr Leu Val Arg Leu Pro Cys 15 20 25 gcc gtg ctg cgc gcg cgc ctg ctg cag ccg cgc gtc cgt gac ctg cta 207 Ala Val Leu Arg Ala Arg Leu Leu Gln Pro Arg Val Arg Asp Leu Leu 30 35 40 45 gct gag cag cgc ttc ccg ggc cgc gtg ctg ccc tcg gac ttg gac ctg 255 Ala Glu Gln Arg Phe Pro Gly Arg Val Leu Pro Ser Asp Leu Asp Leu 50 55 60 ctg ttg cac atg aac aac gcg cgc tac ctg cgc gag gcc gac ttt gcg 303 Leu Leu His Met Asn Asn Ala Arg Tyr Leu Arg Glu Ala Asp Phe Ala 65 70 75 cgc gtc gcg cac ctg acc cgc tgc ggg gtg ctc ggg gcg ctg agg gag 351 Arg Val Ala His Leu Thr Arg Cys Gly Val Leu Gly Ala Leu Arg Glu 80 85 90 ttg cgg gcg cac acg gtg ctg gcg gcc tcg tgc gcg cgc cac cgc cgc 399 Leu Arg Ala His Thr Val Leu Ala Ala Ser Cys Ala Arg His Arg Arg 95 100 105 tcg ctg cgc ctg ctg gag ccc ttc gag gtg cgc acc cgc ctg ctg ggc 447 Ser Leu Arg Leu Leu Glu Pro Phe Glu Val Arg Thr Arg Leu Leu Gly 110 115 120 125 tgg gac gac cgc gcg ttc tac ctg gag gcg cgc ttt gtc agc ctg cgg 495 Trp Asp Asp Arg Ala Phe Tyr Leu Glu Ala Arg Phe Val Ser Leu Arg 130 135 140 gac ggt ttc gtg tgc gcg ctg ctg cgc ttc cgg cag cac ctg ctg ggc 543 Asp Gly Phe Val Cys Ala Leu Leu Arg Phe Arg Gln His Leu Leu Gly 145 150 155 acc tca ccc gag cgc gtc gtg cag cac ctg tgc cag cgc agg gtg gag 591 Thr Ser Pro Glu Arg Val Val Gln His Leu Cys Gln Arg Arg Val Glu 160 165 170 ccc cct gag ctg ccc gct gat ctg cag cac tgg atc tcc tac aac gag 639 Pro Pro Glu Leu Pro Ala Asp Leu Gln His Trp Ile Ser Tyr Asn Glu 175 180 185 gcc agc agc cag ctg ctc cgc atg gag agt ggg ctc agt gat gtc acc 687 Ala Ser Ser Gln Leu Leu Arg Met Glu Ser Gly Leu Ser Asp Val Thr 190 195 200 205 aag gac cag tgaccgccac cttcacaccg tctgccctgg ccaccatcct 736 Lys Asp Gln gggcctgggg gctgcccaca gatgggcagt ctcagccata ctctgttcca gctggagtag 796 cctcctgacc agcctggccc accctgctcc acccactggg cccccccagt tattgatacc 856 cctctgtgct gggctccacg ctaggcagaa ggaggagtgg cattggcatc ctgacccagc 916 tctgccctca aggtggggat ggatgggcaa aggagagtcc tgcctggccc tacgatgagg 976 ccactcatgt gggcctaggt aggggaggat ggtgcctgga gcagagggac ccacaagtgc 1036 ctcccgagcc tagatcctgg ctcggaccac tgcaagggcc gaggcagggc cagaccagag 1096 catcctgggt acaggcctgg gctctccagg gtctgggcct gattcaggtg cagtgggcac 1156 tcctgaaggg tcagagcggc atctgccagg cagcccctct ggcttccgct gaggtggttg 1216 caggcctggg gcagagcctg ggtggtcaga ggccggggct agaggcagat ggaagggagg 1276 cacttgctga cagaggacgg ggcacccggg ctccccactg cagtcggcct tgcctcctcc 1336 tcctcctcta cctccagtca ggctggacgg aagggtagcc ttgtggctga gaggggtcag 1396 actaggtggc acaggggctc ctggaaagac agcaggcttc ctgctgggcg ttcccttgtt 1456 ggagggaata gagtgggggt gggactctgc aggggtgtcc ttgtccactc gcacccctcg 1516 ccgcccacca gggccatgct ctgtgacttg ggctgatccc caccctttct gggcctacag 1576 caccacaggc cgctgtaccc ccttagagct gcccctctct ggcctggccg gcaggcgtct 1636 tcttaactcc tctgtcctct atattcagca tgttccttgt cagctgctgg gccggccctg 1696 ccttgcgcta gcagagcctc tcctggcagc ttctcaggtc tccctaatgg agacaccagg 1756 ctactaggac actggctggg gccaccccct cctgcctaat gcctcacctt acagctgggg 1816 aaactgaggc ctggaatggc ccagagtcac caaggcaaag ttggggctgg tcccagcctg 1876 aggctccagc tgatgccctc agctcccaga gagggggtgc cccatctagc tgggtgcagg 1936 ggtcactgct tgtcagctca gggccctgtg cccgcttgcc tgttccccta catctgtgcc 1996 tgcacatcca gaactgcctc cttgccgctg cctccaggaa gcccaccttg agccagagtc 2056 aagggctgca gcactgcccg atagaacacg cccgccctca ctgctgttct tgccttacag 2116 ccaccatggg aaagctgcaa cctttctgtt ttatttaaag aaagcccaac attaaagggt 2176 tttcattgc 2185 <210> 96 <211> 208 <212> PRT <213> Homo sapiens <400> 96 Met Leu Gly Leu Leu Val Ala Leu Leu Ala Leu Gly Leu Ala Val Phe 1 5 10 15 Ala Leu Leu Gly Val Trp Tyr Leu Val Arg Leu Pro Cys Ala Val Leu 20 25 30 Arg Ala Arg Leu Leu Gln Pro Arg Val Arg Asp Leu Leu Ala Glu Gln 35 40 45 Arg Phe Pro Gly Arg Val Leu Pro Ser Asp Leu Asp Leu Leu Leu His 50 55 60 Met Asn Asn Ala Arg Tyr Leu Arg Glu Ala Asp Phe Ala Arg Val Ala 65 70 75 80 His Leu Thr Arg Cys Gly Val Leu Gly Ala Leu Arg Glu Leu Arg Ala 85 90 95 His Thr Val Leu Ala Ala Ser Cys Ala Arg His Arg Arg Ser Leu Arg 100 105 110 Leu Leu Glu Pro Phe Glu Val Arg Thr Arg Leu Leu Gly Trp Asp Asp 115 120 125 Arg Ala Phe Tyr Leu Glu Ala Arg Phe Val Ser Leu Arg Asp Gly Phe 130 135 140 Val Cys Ala Leu Leu Arg Phe Arg Gln His Leu Leu Gly Thr Ser Pro 145 150 155 160 Glu Arg Val Val Gln His Leu Cys Gln Arg Arg Val Glu Pro Pro Glu 165 170 175 Leu Pro Ala Asp Leu Gln His Trp Ile Ser Tyr Asn Glu Ala Ser Ser 180 185 190 Gln Leu Leu Arg Met Glu Ser Gly Leu Ser Asp Val Thr Lys Asp Gln 195 200 205 <210> 97 <211> 1627 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (251)..(1300) <400> 97 agctggcgct ggaggcttcg gcgtcacgtg ctggtctgga tttttctcga tgcactgggg 60 aaagcggtgg actcttatcg tgggagggct cttgatctgt gatttataga taggcacagg 120 gaacccaacg gcagacaggt cctagtgccc atcagatacc cgcggccggg actcggagct 180 gtggggtgtg gggaggcgga ggcaccaact aagagcggcc tagcatcgca aagccgccct 240 cggggcgctc atg gcg gga cgc ctc ctg gga aag gct ttg gcc gcg gtg 289 Met Ala Gly Arg Leu Leu Gly Lys Ala Leu Ala Ala Val 1 5 10 tct ctc tct ctg gcc ttg gcc tct gtg act atc agg tcc tcg cgc tgc 337 Ser Leu Ser Leu Ala Leu Ala Ser Val Thr Ile Arg Ser Ser Arg Cys 15 20 25 cgc ggc atc cag gcg ttc aga aac tcg ttt tca tct tct tgg ttt cat 385 Arg Gly Ile Gln Ala Phe Arg Asn Ser Phe Ser Ser Ser Trp Phe His 30 35 40 45 ctt aat acc aac gtc atg tct ggt tct aat ggt tcc aaa gaa aat tct 433 Leu Asn Thr Asn Val Met Ser Gly Ser Asn Gly Ser Lys Glu Asn Ser 50 55 60 cac aat aag gct cgg acg tct cct tac cca ggt tca aaa gtt gaa cga 481 His Asn Lys Ala Arg Thr Ser Pro Tyr Pro Gly Ser Lys Val Glu Arg 65 70 75 agc cag gtt cct aat gag aaa gtg ggc tgg ctt gtt gag tgg caa gac 529 Ser Gln Val Pro Asn Glu Lys Val Gly Trp Leu Val Glu Trp Gln Asp 80 85 90 tat aag cct gtg gaa tac act gca gtc tct gtc ttg gct gga ccc agg 577 Tyr Lys Pro Val Glu Tyr Thr Ala Val Ser Val Leu Ala Gly Pro Arg 95 100 105 tgg gca gat cct cag atc agt gaa agt aat ttt tct ccc aag ttt aac 625 Trp Ala Asp Pro Gln Ile Ser Glu Ser Asn Phe Ser Pro Lys Phe Asn 110 115 120 125 gaa aag gat ggg cat gtt gag aga aag agc aag aat ggc ctg tat gag 673 Glu Lys Asp Gly His Val Glu Arg Lys Ser Lys Asn Gly Leu Tyr Glu 130 135 140 att gaa aat gga aga ccg aga aat cct gca gga cgg act gga ctg gtg 721 Ile Glu Asn Gly Arg Pro Arg Asn Pro Ala Gly Arg Thr Gly Leu Val 145 150 155 ggc cgg ggg ctt ttg ggg cga tgg ggc cca aat cac gct gca gat ccc 769 Gly Arg Gly Leu Leu Gly Arg Trp Gly Pro Asn His Ala Ala Asp Pro 160 165 170 att ata acc aga tgg aaa agg gat agc agt gga aat aaa atc atg cat 817 Ile Ile Thr Arg Trp Lys Arg Asp Ser Ser Gly Asn Lys Ile Met His 175 180 185 cct gtt tct ggg aag cat atc tta caa ttt gtt gca ata aaa agg aaa 865 Pro Val Ser Gly Lys His Ile Leu Gln Phe Val Ala Ile Lys Arg Lys 190 195 200 205 gac tgt gga gaa tgg gca atc cca ggg ggg atg gtg gat cca gga gag 913 Asp Cys Gly Glu Trp Ala Ile Pro Gly Gly Met Val Asp Pro Gly Glu 210 215 220 aag att agt gcc aca ctg aaa aga gaa ttt ggt gag gaa gct ctc aac 961 Lys Ile Ser Ala Thr Leu Lys Arg Glu Phe Gly Glu Glu Ala Leu Asn 225 230 235 tcc tta cag aaa acc agt gct gag aag aga gaa ata gag gaa aag ttg 1009 Ser Leu Gln Lys Thr Ser Ala Glu Lys Arg Glu Ile Glu Glu Lys Leu 240 245 250 cac aaa ctc ttc agc caa gac cac cta gtg ata tat aag gga tat gtt 1057 His Lys Leu Phe Ser Gln Asp His Leu Val Ile Tyr Lys Gly Tyr Val 255 260 265 gat gat cct cga aac act gat aat gca tgg atg gag aca gaa gct gtg 1105 Asp Asp Pro Arg Asn Thr Asp Asn Ala Trp Met Glu Thr Glu Ala Val 270 275 280 285 aac tac cat gac gaa aca ggt gtg ata atg gat aat ctt atg cta gaa 1153 Asn Tyr His Asp Glu Thr Gly Val Ile Met Asp Asn Leu Met Leu Glu 290 295 300 gct gga gat gat gct gga aaa gtg aaa tgg gtg gac atc aat gat aaa 1201 Ala Gly Asp Asp Ala Gly Lys Val Lys Trp Val Asp Ile Asn Asp Lys 305 310 315 ctg aag ctt tat gcc agt cac tct caa ttc atc aaa ctt gtg gct gag 1249 Leu Lys Leu Tyr Ala Ser His Ser Gln Phe Ile Lys Leu Val Ala Glu 320 325 330 aaa cga gat gca cac tgg agc gag gac tct gaa gct gac tgc cat gcg 1297 Lys Arg Asp Ala His Trp Ser Glu Asp Ser Glu Ala Asp Cys His Ala 335 340 345 ttg tagctgatgg tctccgtgta agccaaaggc ccacagagga gcatatactg 1350 Leu 350 aaaagaaggc agtatcacag aatttatact ataaaaaggg cagggtaggc cacttggcct 1410 atttactttc aaaacaactt gcatttagag tgtttcgcat cagaataaca tgagtaagat 1470 gaactggaac acaaaatttt cagctctttg gtcaaaagga atataagtaa tcatattttg 1530 tatgtattcg atttaagcat ggcttaaatt aaatttaaac aactaatgct ctttgaagaa 1590 tcataatcag aataaagata aattcttgat cagctat 1627 <210> 98 <211> 350 <212> PRT <213> Homo sapiens <400> 98 Met Ala Gly Arg Leu Leu Gly Lys Ala Leu Ala Ala Val Ser Leu Ser 1 5 10 15 Leu Ala Leu Ala Ser Val Thr Ile Arg Ser Ser Arg Cys Arg Gly Ile 20 25 30 Gln Ala Phe Arg Asn Ser Phe Ser Ser Ser Trp Phe His Leu Asn Thr 35 40 45 Asn Val Met Ser Gly Ser Asn Gly Ser Lys Glu Asn Ser His Asn Lys 50 55 60 Ala Arg Thr Ser Pro Tyr Pro Gly Ser Lys Val Glu Arg Ser Gln Val 65 70 75 80 Pro Asn Glu Lys Val Gly Trp Leu Val Glu Trp Gln Asp Tyr Lys Pro 85 90 95 Val Glu Tyr Thr Ala Val Ser Val Leu Ala Gly Pro Arg Trp Ala Asp 100 105 110 Pro Gln Ile Ser Glu Ser Asn Phe Ser Pro Lys Phe Asn Glu Lys Asp 115 120 125 Gly His Val Glu Arg Lys Ser Lys Asn Gly Leu Tyr Glu Ile Glu Asn 130 135 140 Gly Arg Pro Arg Asn Pro Ala Gly Arg Thr Gly Leu Val Gly Arg Gly 145 150 155 160 Leu Leu Gly Arg Trp Gly Pro Asn His Ala Ala Asp Pro Ile Ile Thr 165 170 175 Arg Trp Lys Arg Asp Ser Ser Gly Asn Lys Ile Met His Pro Val Ser 180 185 190 Gly Lys His Ile Leu Gln Phe Val Ala Ile Lys Arg Lys Asp Cys Gly 195 200 205 Glu Trp Ala Ile Pro Gly Gly Met Val Asp Pro Gly Glu Lys Ile Ser 210 215 220 Ala Thr Leu Lys Arg Glu Phe Gly Glu Glu Ala Leu Asn Ser Leu Gln 225 230 235 240 Lys Thr Ser Ala Glu Lys Arg Glu Ile Glu Glu Lys Leu His Lys Leu 245 250 255 Phe Ser Gln Asp His Leu Val Ile Tyr Lys Gly Tyr Val Asp Asp Pro 260 265 270 Arg Asn Thr Asp Asn Ala Trp Met Glu Thr Glu Ala Val Asn Tyr His 275 280 285 Asp Glu Thr Gly Val Ile Met Asp Asn Leu Met Leu Glu Ala Gly Asp 290 295 300 Asp Ala Gly Lys Val Lys Trp Val Asp Ile Asn Asp Lys Leu Lys Leu 305 310 315 320 Tyr Ala Ser His Ser Gln Phe Ile Lys Leu Val Ala Glu Lys Arg Asp 325 330 335 Ala His Trp Ser Glu Asp Ser Glu Ala Asp Cys His Ala Leu 340 345 350 <210> 99 <211> 1391 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (74)..(589) <400> 99 gaactgtgtg gaccgtctgc tgggactccg gccctgcgtc cgctcagccc cgtggccccg 60 cgcacctact gcc atg gag acg cgg cct cgt ctc ggg gcc acc tgt ttg 109 Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu 1 5 10 ctg ggc ttc agt ttc ctg ctc ctc gtc atc tct tct gat gga cat aat 157 Leu Gly Phe Ser Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn 15 20 25 ggg ctt gga aag ggt ttt gga gat cat att cat tgg agg aca ctg gaa 205 Gly Leu Gly Lys Gly Phe Gly Asp His Ile His Trp Arg Thr Leu Glu 30 35 40 gat ggg aag aaa gaa gca gct gcc agt gga ctg ccc ctg atg gtg att 253 Asp Gly Lys Lys Glu Ala Ala Ala Ser Gly Leu Pro Leu Met Val Ile 45 50 55 60 att cat aaa tcc tgg tgt gga gct tgc aaa gct cta aag ccc aaa ttt 301 Ile His Lys Ser Trp Cys Gly Ala Cys Lys Ala Leu Lys Pro Lys Phe 65 70 75 gca gaa tct acg gaa att tca gaa ctc tcc cat aat ttt gtt atg gta 349 Ala Glu Ser Thr Glu Ile Ser Glu Leu Ser His Asn Phe Val Met Val 80 85 90 aat ctt gag gat gaa gag gaa ccc aaa gat gaa gat ttc agc cct gac 397 Asn Leu Glu Asp Glu Glu Glu Pro Lys Asp Glu Asp Phe Ser Pro Asp 95 100 105 ggg ggt tat att cca cga atc ctt ttt ctg gat ccc agt ggc aag gtg 445 Gly Gly Tyr Ile Pro Arg Ile Leu Phe Leu Asp Pro Ser Gly Lys Val 110 115 120 cat cct gaa atc atc aat gag aat gga aac ccc agc tac aag tat ttt 493 His Pro Glu Ile Ile Asn Glu Asn Gly Asn Pro Ser Tyr Lys Tyr Phe 125 130 135 140 tat gtc agt gcc gag caa gtt gtt cag ggg atg aag gaa gct cag gaa 541 Tyr Val Ser Ala Glu Gln Val Val Gln Gly Met Lys Glu Ala Gln Glu 145 150 155 agg ctg acg ggt gat gcc ttc aga aag aaa cat ctt gaa gat gaa ttg 589 Arg Leu Thr Gly Asp Ala Phe Arg Lys Lys His Leu Glu Asp Glu Leu 160 165 170 taacatgaat gtgccccttc tttcatcaga gttagtgttc tggaaggaaa gcagcaggga 649 agggaatatt gaggaatcat ctagaacaat taagccgacc aggaaacctc attcctacct 709 acactggaag gagcgctctc actgtggaag agttctgcta acagaagctg gtctgcatgt 769 ttgtggatcc agcggagagt ggcagacttt cttctccttt tccctctcac ctaaatgtca 829 acttgtcatt gaatgtaaag aatgatacct tctgacacaa aacttgagcc acttggatgt 889 ttactcctcg cacttaagta tttgagtctt ttcccatttc ctcccacttt actcacctta 949 gtggtgaaag gagactagta gcatcttttc tacaacgtta aaattgcaga agtagcttat 1009 cattaaaaaa caacaacaac aacaataaca ataaatccta agtgtaaatc agttattcta 1069 ccccctacca aggatatcag cctgtttttt cccttttttc tcctgggaat aattgtgggc 1129 ttcttcccaa atttctacag cctctttcct cttctcatgc ttgagcttcc ctgtttgcac 1189 gcatgcgtgt gcaggactgg ctgtgtgctt ggactcggct ccaggtggaa gcatgctttc 1249 ccttgttact gttggagaaa ctcaaacctt caagccctag gtgtagccat tttgtcaagt 1309 catcaactgt atttttgtac tggcattaac aaaaaaagag ataaaatatt gtaccattaa 1369 actttaataa aactttaaaa gg 1391 <210> 100 <211> 172 <212> PRT <213> Homo sapiens <400> 100 Met Glu Thr Arg Pro Arg Leu Gly Ala Thr Cys Leu Leu Gly Phe Ser 1 5 10 15 Phe Leu Leu Leu Val Ile Ser Ser Asp Gly His Asn Gly Leu Gly Lys 20 25 30 Gly Phe Gly Asp His Ile His Trp Arg Thr Leu Glu Asp Gly Lys Lys 35 40 45 Glu Ala Ala Ala Ser Gly Leu Pro Leu Met Val Ile Ile His Lys Ser 50 55 60 Trp Cys Gly Ala Cys Lys Ala Leu Lys Pro Lys Phe Ala Glu Ser Thr 65 70 75 80 Glu Ile Ser Glu Leu Ser His Asn Phe Val Met Val Asn Leu Glu Asp 85 90 95 Glu Glu Glu Pro Lys Asp Glu Asp Phe Ser Pro Asp Gly Gly Tyr Ile 100 105 110 Pro Arg Ile Leu Phe Leu Asp Pro Ser Gly Lys Val His Pro Glu Ile 115 120 125 Ile Asn Glu Asn Gly Asn Pro Ser Tyr Lys Tyr Phe Tyr Val Ser Ala 130 135 140 Glu Gln Val Val Gln Gly Met Lys Glu Ala Gln Glu Arg Leu Thr Gly 145 150 155 160 Asp Ala Phe Arg Lys Lys His Leu Glu Asp Glu Leu 165 170 <210> 101 <211> 2547 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (166)..(939) <400> 101 gcacagggag ccggctaaaa cagactactc ccccgtgcag tcgttccctc taccctaata 60 aggctttggc gcctctccca gaactcggtc ctggggaatg ctctttgcct ggtccagccc 120 cgacaaacgt ggtctgagaa cagcggagcg cggaaaccgc ggagc atg act cct ccg 177 Met Thr Pro Pro 1 aag ctg cga gcg tcg ctg tcg ccg tcg ctg ctg ctg ctg ctg agt ggt 225 Lys Leu Arg Ala Ser Leu Ser Pro Ser Leu Leu Leu Leu Leu Ser Gly 5 10 15 20 tgc ctc ctc gcg gct gct cgg agg gag aaa ggg gcg gct agc aac gtg 273 Cys Leu Leu Ala Ala Ala Arg Arg Glu Lys Gly Ala Ala Ser Asn Val 25 30 35 gcg gag ccg gtc ccc ggg ccc act ggc ggc tcc tcg ggt cgc ttc ctc 321 Ala Glu Pro Val Pro Gly Pro Thr Gly Gly Ser Ser Gly Arg Phe Leu 40 45 50 agc ccc gag cag cac gcg tgc agc tgg cag ctc ctg ctg ccc gcc ccg 369 Ser Pro Glu Gln His Ala Cys Ser Trp Gln Leu Leu Leu Pro Ala Pro 55 60 65 gag gcc gca gcg ggc agc gag ctg gcg ctg cgc tgc cag agc ccg gac 417 Glu Ala Ala Ala Gly Ser Glu Leu Ala Leu Arg Cys Gln Ser Pro Asp 70 75 80 ggg gcg cgc cac cag tgc gcc tac cgc ggg cat ccg gag cgc tgc gca 465 Gly Ala Arg His Gln Cys Ala Tyr Arg Gly His Pro Glu Arg Cys Ala 85 90 95 100 gcc tac gcc gct cgc cgc gcg cac ttc tgg aag cag gtg ctg gga ggg 513 Ala Tyr Ala Ala Arg Arg Ala His Phe Trp Lys Gln Val Leu Gly Gly 105 110 115 ctg cgc aag aag cgg agg ccc tgt cac gac ccc gcg ccg ctc cag gcc 561 Leu Arg Lys Lys Arg Arg Pro Cys His Asp Pro Ala Pro Leu Gln Ala 120 125 130 cgc ttg tgc gcg ggc aag aag ggc cac ggc gcc gag ctg cgg cta gtg 609 Arg Leu Cys Ala Gly Lys Lys Gly His Gly Ala Glu Leu Arg Leu Val 135 140 145 ccc cgc gcg tcc ccg ccc gca cgc ccc acc gtc gcg gga ttc gcg ggg 657 Pro Arg Ala Ser Pro Pro Ala Arg Pro Thr Val Ala Gly Phe Ala Gly 150 155 160 gag tcc aag ccc cgg gcc cgg aac cgg ggg cgg acc cgg gag cgt gcg 705 Glu Ser Lys Pro Arg Ala Arg Asn Arg Gly Arg Thr Arg Glu Arg Ala 165 170 175 180 tcc ggc cca gcc gct ggg acc ccg cct ccc caa agc gca ccg ccc aaa 753 Ser Gly Pro Ala Ala Gly Thr Pro Pro Pro Gln Ser Ala Pro Pro Lys 185 190 195 gaa aac ccc tca gag agg aag acc aac gtg ggc aag agg aag gcg gcc 801 Glu Asn Pro Ser Glu Arg Lys Thr Asn Val Gly Lys Arg Lys Ala Ala 200 205 210 ttg gtc ccc aac gag gag cga ccc atg ggg acc ggg ccc gac ccc gac 849 Leu Val Pro Asn Glu Glu Arg Pro Met Gly Thr Gly Pro Asp Pro Asp 215 220 225 ggg ctg gac ggg aac gcg gag ctc acg gag acc tac tgc gct gag aag 897 Gly Leu Asp Gly Asn Ala Glu Leu Thr Glu Thr Tyr Cys Ala Glu Lys 230 235 240 tgg cac tcc ctc tgc aac ttc ttt gtc aat ttc tgg aac ggc 939 Trp His Ser Leu Cys Asn Phe Phe Val Asn Phe Trp Asn Gly 245 250 255 tgagactgcc tgccggctta gggagggttg atgggggagg cgtggggaag ggaaagctaa 999 gggcgtctta gaccgggggg tactgtgata gagattgggg agaagtccag gttctcgaat 1059 gggggtgggg gcaagggtaa gggtgagatg cttgggatga gagtgtaagg ggtatggaga 1119 atctctggga tagcagagaa gttaaaaatt ttgaaaagtc tcagtcctga ttaagagcag 1179 gaaaaataat ggaaacagaa ataggcgtac tttaaatgtg caaaaactgg agactgggga 1239 gagaaatcga tgcagagaga ggctgagaat aagggggaga tagagtgact aaagtgatgt 1299 gagtcccatg tggggagggg gatgcaatgt ttattgttta acatttctat taaatgcagc 1359 catgagcaat tgccaacctg agccaggttg aatcaatgtc ttctcactta atcagctaac 1419 aagactgcag actttttttc cgtttctgaa ttggtataaa cttggatgcg gcgtggtggg 1479 tgtcatagat aacctctata gggacagaag cctcacaggt caagactggc tccaaggaaa 1539 gttttgcaga atgatttcct ttccattctt ttagaagagc tacctttttt tttttttttc 1599 cctgacaggg tctggcttgc ccaggctgga gtgcggtggc tagtcacagg tgtaataata 1659 ggcactgcag tctccaactc ctggcctcaa gggatcctca catcttagcc tccagaatag 1719 ctaggagtag gagtagctgg gactacaagc atgcacagct gcacttggct tagaagtgct 1779 actttatttt tatttttgag acagggtctt gtgtcatcca gactggagca gtggtgcaat 1839 tatggctcac tgcggcctcg actttccagt ctcaagtgat cctctgcctc agcctccgga 1899 gtagccagga ctacaggggt gtgccactag aagtgctact ttttaacgaa atggtgacta 1959 atgttctgga actttcccat taaccttctg catttagaag gaattataga tgttgagtgc 2019 tccagtaaac agtgattctc tttatatctg attttttttt tttaaacagc taaaatgtaa 2079 gtatgtatct cagagtcatt ttgaccatta tggaagttat atctctctgt ttcatgtaac 2139 taattattaa tatatttcat ttttagtgtg atgtaatgag agactgtgtg tgtatgttag 2199 gtgctcaata aaaactgtat ggttagattt aaagaagtgg caaggcaatg gaaattctac 2259 ctgcatttga tctacttcca agtacacctt gaattaagtt cttaaacaca tcttgaattg 2319 ctgggaaaag acagaaacta agaagttgac ataaagcaag agtcacaaac tggcagccac 2379 ctggccttat cattgttcta tttgatttgc accctggttc tctttctttt tcccttcctc 2439 cccaccttcc tcccatccat tgttgaatct gtggatgcag agcccacgga tgtggagggg 2499 caactatata tatgtttttc cattatatat ataaatgtgt gtgtatgt 2547 <210> 102 <211> 258 <212> PRT <213> Homo sapiens <400> 102 Met Thr Pro Pro Lys Leu Arg Ala Ser Leu Ser Pro Ser Leu Leu Leu 1 5 10 15 Leu Leu Ser Gly Cys Leu Leu Ala Ala Ala Arg Arg Glu Lys Gly Ala 20 25 30 Ala Ser Asn Val Ala Glu Pro Val Pro Gly Pro Thr Gly Gly Ser Ser 35 40 45 Gly Arg Phe Leu Ser Pro Glu Gln His Ala Cys Ser Trp Gln Leu Leu 50 55 60 Leu Pro Ala Pro Glu Ala Ala Ala Gly Ser Glu Leu Ala Leu Arg Cys 65 70 75 80 Gln Ser Pro Asp Gly Ala Arg His Gln Cys Ala Tyr Arg Gly His Pro 85 90 95 Glu Arg Cys Ala Ala Tyr Ala Ala Arg Arg Ala His Phe Trp Lys Gln 100 105 110 Val Leu Gly Gly Leu Arg Lys Lys Arg Arg Pro Cys His Asp Pro Ala 115 120 125 Pro Leu Gln Ala Arg Leu Cys Ala Gly Lys Lys Gly His Gly Ala Glu 130 135 140 Leu Arg Leu Val Pro Arg Ala Ser Pro Pro Ala Arg Pro Thr Val Ala 145 150 155 160 Gly Phe Ala Gly Glu Ser Lys Pro Arg Ala Arg Asn Arg Gly Arg Thr 165 170 175 Arg Glu Arg Ala Ser Gly Pro Ala Ala Gly Thr Pro Pro Pro Gln Ser 180 185 190 Ala Pro Pro Lys Glu Asn Pro Ser Glu Arg Lys Thr Asn Val Gly Lys 195 200 205 Arg Lys Ala Ala Leu Val Pro Asn Glu Glu Arg Pro Met Gly Thr Gly 210 215 220 Pro Asp Pro Asp Gly Leu Asp Gly Asn Ala Glu Leu Thr Glu Thr Tyr 225 230 235 240 Cys Ala Glu Lys Trp His Ser Leu Cys Asn Phe Phe Val Asn Phe Trp 245 250 255 Asn Gly <210> 103 <211> 1430 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (80)..(1333) <400> 103 gtgcgtttgt ggccgtccgg cctccctgac atgcagccct ctggaccccg aggttggacc 60 ctactgtgac acacctacc atg cgg aca ctc ttc aac ctc ctc tgg ctt gcc 112 Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala 1 5 10 ctg gcc tgc agc cct gtt cac act acc ctg tca aag tca gat gcc aaa 160 Leu Ala Cys Ser Pro Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys 15 20 25 aaa gcc gcc tca aag acg ctg ctg gag aag gtg aag ttt tgc tct tgt 208 Lys Ala Ala Ser Lys Thr Leu Leu Glu Lys Val Lys Phe Cys Ser Cys 30 35 40 tgc cca ggc tgg agc gca atg gcg cga tct tgg ctc acc gca acc tct 256 Cys Pro Gly Trp Ser Ala Met Ala Arg Ser Trp Leu Thr Ala Thr Ser 45 50 55 gcc acc cag agt cag ttt tca gat aag ccg gtg caa gac cgg ggt ttg 304 Ala Thr Gln Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg Gly Leu 60 65 70 75 gtg gtg acg gac ctc aaa gct gag agt gtg gtt ctt gag cat cgc agc 352 Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His Arg Ser 80 85 90 tac tgc tcg gca aag gcc cgg gac aga cac ttt gct ggg gat gta ctg 400 Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp Val Leu 95 100 105 ggc tat gtc act cca tgg aac agc cat ggc tac gat gtc acc aag gtc 448 Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr Lys Val 110 115 120 ttt ggg agc aag ttc aca cag atc tca ccc gtc tgg ctg cag ctg aag 496 Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln Leu Lys 125 130 135 aga cgt ggc cgt gag atg ttt gag gtc acg ggc ctc cac gac gtg gac 544 Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp Val Asp 140 145 150 155 caa ggg tgg atg cga gct gtc agg aag cat gcc aag ggc ctg cac ata 592 Gln Gly Trp Met Arg Ala Val Arg Lys His Ala Lys Gly Leu His Ile 160 165 170 gtg cct cgg ctc ctg ttt gag gac tgg act tac gat gat ttc cgg aac 640 Val Pro Arg Leu Leu Phe Glu Asp Trp Thr Tyr Asp Asp Phe Arg Asn 175 180 185 gtc tta gac agt gag gat gag ata gag gag ctg agc aag acc gtg gtc 688 Val Leu Asp Ser Glu Asp Glu Ile Glu Glu Leu Ser Lys Thr Val Val 190 195 200 cag gtg gca aag aac cag cat ttc gat ggc ttc gtg gtg gag gtc tgg 736 Gln Val Ala Lys Asn Gln His Phe Asp Gly Phe Val Val Glu Val Trp 205 210 215 aac cag ctg cta agc cag aag cgc gtg ggc ctc atc cac atg ctc acc 784 Asn Gln Leu Leu Ser Gln Lys Arg Val Gly Leu Ile His Met Leu Thr 220 225 230 235 cac ttg gcc gag gct ctg cac cag gcc cgg ctg ctg gcc ctc ctg gtc 832 His Leu Ala Glu Ala Leu His Gln Ala Arg Leu Leu Ala Leu Leu Val 240 245 250 atc ccg cct gcc atc acc ccc ggg acc gac cag ctg ggc atg ttc acg 880 Ile Pro Pro Ala Ile Thr Pro Gly Thr Asp Gln Leu Gly Met Phe Thr 255 260 265 cac aag gag ttt gag cag ctg gcc ccc gtg ctg gat ggt ttc agc ctc 928 His Lys Glu Phe Glu Gln Leu Ala Pro Val Leu Asp Gly Phe Ser Leu 270 275 280 atg acc tac gac tac tct aca gcg cat cag cct ggc cct aat gca ccc 976 Met Thr Tyr Asp Tyr Ser Thr Ala His Gln Pro Gly Pro Asn Ala Pro 285 290 295 ctg tcc tgg gtt cga gcc tgc gtc cag gtc ctg gac ccg aag tcc aag 1024 Leu Ser Trp Val Arg Ala Cys Val Gln Val Leu Asp Pro Lys Ser Lys 300 305 310 315 tgg cga agc aaa atc ctc ctg ggg ctc aac ttc tat ggt atg gac tac 1072 Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe Tyr Gly Met Asp Tyr 320 325 330 gcg acc tcc aag gat gcc cgt gag cct gtt gtc ggg gcc agg tac atc 1120 Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val Gly Ala Arg Tyr Ile 335 340 345 cag aca ctg aag gac cac agg ccc cgg atg gtg tgg gac agc cag gcc 1168 Gln Thr Leu Lys Asp His Arg Pro Arg Met Val Trp Asp Ser Gln Ala 350 355 360 tca gag cac ttc ttc gag tac aag aag agc cgc agt ggg agg cac gtc 1216 Ser Glu His Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly Arg His Val 365 370 375 gtc ttc tac cca acc ctg aag tcc ctg cag gtg cgg ctg gag ctg gcc 1264 Val Phe Tyr Pro Thr Leu Lys Ser Leu Gln Val Arg Leu Glu Leu Ala 380 385 390 395 cgg gag ctg ggc gtt ggg gtc tct atc tgg gag ctg ggc cag ggc ctg 1312 Arg Glu Leu Gly Val Gly Val Ser Ile Trp Glu Leu Gly Gln Gly Leu 400 405 410 gac tac ttc tac gac ctg ctc taggtgggca ttgcggcctc cgcggtggac 1363 Asp Tyr Phe Tyr Asp Leu Leu 415 gtgttctttt ctaagccatg gagtgagtga gcaggtgtga aatacaggcc tccctccgtt 1423 tgctgtg 1430 <210> 104 <211> 418 <212> PRT <213> Homo sapiens <400> 104 Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro 1 5 10 15 Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 20 25 30 Thr Leu Leu Glu Lys Val Lys Phe Cys Ser Cys Cys Pro Gly Trp Ser 35 40 45 Ala Met Ala Arg Ser Trp Leu Thr Ala Thr Ser Ala Thr Gln Ser Gln 50 55 60 Phe Ser Asp Lys Pro Val Gln Asp Arg Gly Leu Val Val Thr Asp Leu 65 70 75 80 Lys Ala Glu Ser Val Val Leu Glu His Arg Ser Tyr Cys Ser Ala Lys 85 90 95 Ala Arg Asp Arg His Phe Ala Gly Asp Val Leu Gly Tyr Val Thr Pro 100 105 110 Trp Asn Ser His Gly Tyr Asp Val Thr Lys Val Phe Gly Ser Lys Phe 115 120 125 Thr Gln Ile Ser Pro Val Trp Leu Gln Leu Lys Arg Arg Gly Arg Glu 130 135 140 Met Phe Glu Val Thr Gly Leu His Asp Val Asp Gln Gly Trp Met Arg 145 150 155 160 Ala Val Arg Lys His Ala Lys Gly Leu His Ile Val Pro Arg Leu Leu 165 170 175 Phe Glu Asp Trp Thr Tyr Asp Asp Phe Arg Asn Val Leu Asp Ser Glu 180 185 190 Asp Glu Ile Glu Glu Leu Ser Lys Thr Val Val Gln Val Ala Lys Asn 195 200 205 Gln His Phe Asp Gly Phe Val Val Glu Val Trp Asn Gln Leu Leu Ser 210 215 220 Gln Lys Arg Val Gly Leu Ile His Met Leu Thr His Leu Ala Glu Ala 225 230 235 240 Leu His Gln Ala Arg Leu Leu Ala Leu Leu Val Ile Pro Pro Ala Ile 245 250 255 Thr Pro Gly Thr Asp Gln Leu Gly Met Phe Thr His Lys Glu Phe Glu 260 265 270 Gln Leu Ala Pro Val Leu Asp Gly Phe Ser Leu Met Thr Tyr Asp Tyr 275 280 285 Ser Thr Ala His Gln Pro Gly Pro Asn Ala Pro Leu Ser Trp Val Arg 290 295 300 Ala Cys Val Gln Val Leu Asp Pro Lys Ser Lys Trp Arg Ser Lys Ile 305 310 315 320 Leu Leu Gly Leu Asn Phe Tyr Gly Met Asp Tyr Ala Thr Ser Lys Asp 325 330 335 Ala Arg Glu Pro Val Val Gly Ala Arg Tyr Ile Gln Thr Leu Lys Asp 340 345 350 His Arg Pro Arg Met Val Trp Asp Ser Gln Ala Ser Glu His Phe Phe 355 360 365 Glu Tyr Lys Lys Ser Arg Ser Gly Arg His Val Val Phe Tyr Pro Thr 370 375 380 Leu Lys Ser Leu Gln Val Arg Leu Glu Leu Ala Arg Glu Leu Gly Val 385 390 395 400 Gly Val Ser Ile Trp Glu Leu Gly Gln Gly Leu Asp Tyr Phe Tyr Asp 405 410 415 Leu Leu <210> 105 <211> 2506 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (24)..(1505) <400> 105 gtgctgcccg ctcaccgccc gcc atg gcc cgc gca ccc ccg ctg ctc gcc gcg 53 Met Ala Arg Ala Pro Pro Leu Leu Ala Ala 1 5 10 ttg acc gcg ctc ctc gcc gcc gcc gct gct ggc gga gat gcc ccg ccg 101 Leu Thr Ala Leu Leu Ala Ala Ala Ala Ala Gly Gly Asp Ala Pro Pro 15 20 25 ggc aaa atc gcg gtg gtt ggg gct ggg att ggg ggc tct gct gtg gcc 149 Gly Lys Ile Ala Val Val Gly Ala Gly Ile Gly Gly Ser Ala Val Ala 30 35 40 cat ttt ctc cag cag cac ttc gga cct cgg gtg cag atc gac gtg tac 197 His Phe Leu Gln Gln His Phe Gly Pro Arg Val Gln Ile Asp Val Tyr 45 50 55 gag aag gga acc gtg ggt ggc cgc ttg gcc acc atc tca gtc aac aag 245 Glu Lys Gly Thr Val Gly Gly Arg Leu Ala Thr Ile Ser Val Asn Lys 60 65 70 cag cac tat gag agc ggg gct gcc tcc ttc cac tcc ctg agc ctg cac 293 Gln His Tyr Glu Ser Gly Ala Ala Ser Phe His Ser Leu Ser Leu His 75 80 85 90 atg cag gac ttc gtc aag ctg ctg ggg ctg agg cac cgg cgc gag gtg 341 Met Gln Asp Phe Val Lys Leu Leu Gly Leu Arg His Arg Arg Glu Val 95 100 105 gtg ggc agg agc gcc atc ttc ggc ggg gag cac ttc atg ctg gag gag 389 Val Gly Arg Ser Ala Ile Phe Gly Gly Glu His Phe Met Leu Glu Glu 110 115 120 act gac tgg tac ctg ctg aac ctc ttc cgc ctc tgg tgg cac tat ggc 437 Thr Asp Trp Tyr Leu Leu Asn Leu Phe Arg Leu Trp Trp His Tyr Gly 125 130 135 atc agc ttc ctg agg ctg cag atg tgg gtg gag gag gtc atg gag aag 485 Ile Ser Phe Leu Arg Leu Gln Met Trp Val Glu Glu Val Met Glu Lys 140 145 150 ttc atg agg atc tat aag tac cag gcc cac ggc tat gcc ttc tcg ggt 533 Phe Met Arg Ile Tyr Lys Tyr Gln Ala His Gly Tyr Ala Phe Ser Gly 155 160 165 170 gtg gag gag ctg ctc tac tca ctg ggg gag tcc acc ttt gtt aac atg 581 Val Glu Glu Leu Leu Tyr Ser Leu Gly Glu Ser Thr Phe Val Asn Met 175 180 185 acc cag cac tct gtg gct gag tcc ctg ctg cag gtg ggc gtc acg cag 629 Thr Gln His Ser Val Ala Glu Ser Leu Leu Gln Val Gly Val Thr Gln 190 195 200 cgc ttt att gat gat gtc gtt tct gct gtc ctg cgg gcc agc tat ggc 677 Arg Phe Ile Asp Asp Val Val Ser Ala Val Leu Arg Ala Ser Tyr Gly 205 210 215 cag tca gca gcg atg ccc gcc ttt gca gga gcc atg tca cta gcc ggg 725 Gln Ser Ala Ala Met Pro Ala Phe Ala Gly Ala Met Ser Leu Ala Gly 220 225 230 gcc caa ggc agc ctg tgg tct gtg gaa gga ggc aat aag ctg gtt tgt 773 Ala Gln Gly Ser Leu Trp Ser Val Glu Gly Gly Asn Lys Leu Val Cys 235 240 245 250 tcc ggt ttg ctg aag ctc acc aag gcc aat gtg atc cat gcc aca gtg 821 Ser Gly Leu Leu Lys Leu Thr Lys Ala Asn Val Ile His Ala Thr Val 255 260 265 acc tct gtg acc ctg cac agc aca gag ggg aaa gcc ctg tac cag gtg 869 Thr Ser Val Thr Leu His Ser Thr Glu Gly Lys Ala Leu Tyr Gln Val 270 275 280 gcg tat gag aat gag gta ggc aac agc tct gac ttc tat gac atc gtg 917 Ala Tyr Glu Asn Glu Val Gly Asn Ser Ser Asp Phe Tyr Asp Ile Val 285 290 295 gtc atc gcc acc ccc ctg cac ctg gac aac agc agc agc aac tta acc 965 Val Ile Ala Thr Pro Leu His Leu Asp Asn Ser Ser Ser Asn Leu Thr 300 305 310 ttt gca ggc ttc cac ccg ccc att gat gac gtg cag ggc tct ttc cag 1013 Phe Ala Gly Phe His Pro Pro Ile Asp Asp Val Gln Gly Ser Phe Gln 315 320 325 330 ccc acc gtc gtc tcc ttg gtc cac ggc tac ctc aac tcg tcc tac ttc 1061 Pro Thr Val Val Ser Leu Val His Gly Tyr Leu Asn Ser Ser Tyr Phe 335 340 345 ggt ttc cca gac cct aag ctt ttc ccc ttt gcc aac atc ctt acc aca 1109 Gly Phe Pro Asp Pro Lys Leu Phe Pro Phe Ala Asn Ile Leu Thr Thr 350 355 360 gat ttc ccc agc ttc ttc tgc act ctg gac aac atc tgc cct gtc aac 1157 Asp Phe Pro Ser Phe Phe Cys Thr Leu Asp Asn Ile Cys Pro Val Asn 365 370 375 atc tct gcc agc ttc cgg cga aag cag ccc cag gag gca gct gtt tgg 1205 Ile Ser Ala Ser Phe Arg Arg Lys Gln Pro Gln Glu Ala Ala Val Trp 380 385 390 cga gtc cag tcc ccc aag ccc ctc ttt cgg acc cag cta aag acc ctg 1253 Arg Val Gln Ser Pro Lys Pro Leu Phe Arg Thr Gln Leu Lys Thr Leu 395 400 405 410 ttc cgt tcc tat tac tca gtg cag aca gct gag tgg cag gcc cat ccc 1301 Phe Arg Ser Tyr Tyr Ser Val Gln Thr Ala Glu Trp Gln Ala His Pro 415 420 425 ctc tat ggc tcc cgc ccc acg ctc ccg agg ttt gca ctc cat gac cag 1349 Leu Tyr Gly Ser Arg Pro Thr Leu Pro Arg Phe Ala Leu His Asp Gln 430 435 440 ctc ttc tac ctc aat gcc ctg gag tgg gcg gcc agc tcc gtg gag gtg 1397 Leu Phe Tyr Leu Asn Ala Leu Glu Trp Ala Ala Ser Ser Val Glu Val 445 450 455 atg gcc gtg gct gcc aag aat gtg gcc ttg ctg gct tac aac cgc tgg 1445 Met Ala Val Ala Ala Lys Asn Val Ala Leu Leu Ala Tyr Asn Arg Trp 460 465 470 tac cag gac cta gac aag att gat caa aaa gat ttg atg cac aag gtc 1493 Tyr Gln Asp Leu Asp Lys Ile Asp Gln Lys Asp Leu Met His Lys Val 475 480 485 490 aag act gaa ctg tgagggctct agggagagcc tgggaacttt catcccccac 1545 Lys Thr Glu Leu tgaagatgga tcatcccaca gcagcccagg actgaataag ccatgctcgc ccaccaggct 1605 tctttctgac ccctcatgta tcaagcatct ccaggtgacc tactgtctgc ctatattaag 1665 ggtccacacg gcggctgctg ctttttttta agggggaaag taagaaaaga gaaggaaatc 1725 caagccagta tatttgtttt atttattttt tttaagaaga aaaaagttca tcttcacaag 1785 gtgcttcaga cttggtttct tagctagaaa ccagaagact acgggaggga atataaggca 1845 gagaactatg agtcttattt tattactgtt tttcactacc tactcccaca atggacaatc 1905 aattgaggca acctacaaga aaacatttac aaccagatgg ttacaaataa agtagaaggg 1965 aagatcagaa aacctaagaa atgatcatag ctcctggtta ctgtggactt gatagatttg 2025 aggtacctag ttcagaactc cctagtcacc atctccaagc ctgtcaacat cactgcatat 2085 tggaggagat gactgtggta ggacccaagg aagagatgtg tgcctgaata gtcgtcacca 2145 tatctccaag cttcctggca accagtggga aaagaaacat gcgaggctgt aggaagaggg 2205 aagctcttcc ttggcaccta gaggaattag ccattctctt ccttatgcaa agattgagga 2265 atgcaacaat ataaagaaga gaagtcccca gatggtagag agcagtcata tcttacccct 2325 agatgttcat cccagcagaa gaaagaagaa ggtgttgggg taggattctt cagaggttag 2385 cctggtactt tctcatcgga cactagcttg aagtaagagg agaattatgc ttttctttgc 2445 tttttctaca aacccttaaa aatcacttgt tttaaaaaga aagtaaaagc ccttttcatt 2505 c 2506 <210> 106 <211> 494 <212> PRT <213> Homo sapiens <400> 106 Met Ala Arg Ala Pro Pro Leu Leu Ala Ala Leu Thr Ala Leu Leu Ala 1 5 10 15 Ala Ala Ala Ala Gly Gly Asp Ala Pro Pro Gly Lys Ile Ala Val Val 20 25 30 Gly Ala Gly Ile Gly Gly Ser Ala Val Ala His Phe Leu Gln Gln His 35 40 45 Phe Gly Pro Arg Val Gln Ile Asp Val Tyr Glu Lys Gly Thr Val Gly 50 55 60 Gly Arg Leu Ala Thr Ile Ser Val Asn Lys Gln His Tyr Glu Ser Gly 65 70 75 80 Ala Ala Ser Phe His Ser Leu Ser Leu His Met Gln Asp Phe Val Lys 85 90 95 Leu Leu Gly Leu Arg His Arg Arg Glu Val Val Gly Arg Ser Ala Ile 100 105 110 Phe Gly Gly Glu His Phe Met Leu Glu Glu Thr Asp Trp Tyr Leu Leu 115 120 125 Asn Leu Phe Arg Leu Trp Trp His Tyr Gly Ile Ser Phe Leu Arg Leu 130 135 140 Gln Met Trp Val Glu Glu Val Met Glu Lys Phe Met Arg Ile Tyr Lys 145 150 155 160 Tyr Gln Ala His Gly Tyr Ala Phe Ser Gly Val Glu Glu Leu Leu Tyr 165 170 175 Ser Leu Gly Glu Ser Thr Phe Val Asn Met Thr Gln His Ser Val Ala 180 185 190 Glu Ser Leu Leu Gln Val Gly Val Thr Gln Arg Phe Ile Asp Asp Val 195 200 205 Val Ser Ala Val Leu Arg Ala Ser Tyr Gly Gln Ser Ala Ala Met Pro 210 215 220 Ala Phe Ala Gly Ala Met Ser Leu Ala Gly Ala Gln Gly Ser Leu Trp 225 230 235 240 Ser Val Glu Gly Gly Asn Lys Leu Val Cys Ser Gly Leu Leu Lys Leu 245 250 255 Thr Lys Ala Asn Val Ile His Ala Thr Val Thr Ser Val Thr Leu His 260 265 270 Ser Thr Glu Gly Lys Ala Leu Tyr Gln Val Ala Tyr Glu Asn Glu Val 275 280 285 Gly Asn Ser Ser Asp Phe Tyr Asp Ile Val Val Ile Ala Thr Pro Leu 290 295 300 His Leu Asp Asn Ser Ser Ser Asn Leu Thr Phe Ala Gly Phe His Pro 305 310 315 320 Pro Ile Asp Asp Val Gln Gly Ser Phe Gln Pro Thr Val Val Ser Leu 325 330 335 Val His Gly Tyr Leu Asn Ser Ser Tyr Phe Gly Phe Pro Asp Pro Lys 340 345 350 Leu Phe Pro Phe Ala Asn Ile Leu Thr Thr Asp Phe Pro Ser Phe Phe 355 360 365 Cys Thr Leu Asp Asn Ile Cys Pro Val Asn Ile Ser Ala Ser Phe Arg 370 375 380 Arg Lys Gln Pro Gln Glu Ala Ala Val Trp Arg Val Gln Ser Pro Lys 385 390 395 400 Pro Leu Phe Arg Thr Gln Leu Lys Thr Leu Phe Arg Ser Tyr Tyr Ser 405 410 415 Val Gln Thr Ala Glu Trp Gln Ala His Pro Leu Tyr Gly Ser Arg Pro 420 425 430 Thr Leu Pro Arg Phe Ala Leu His Asp Gln Leu Phe Tyr Leu Asn Ala 435 440 445 Leu Glu Trp Ala Ala Ser Ser Val Glu Val Met Ala Val Ala Ala Lys 450 455 460 Asn Val Ala Leu Leu Ala Tyr Asn Arg Trp Tyr Gln Asp Leu Asp Lys 465 470 475 480 Ile Asp Gln Lys Asp Leu Met His Lys Val Lys Thr Glu Leu 485 490 <210> 107 <211> 2465 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (457)..(1434) <400> 107 agccagggaa gcctccgcgg tggtgcaagt ggaacccaag ccttgaggtt tcagtgagta 60 gggggccgac gtgagcttta gcgtccccct ttagcctccc tcttcgattc cttgaagacc 120 ctggtgcagc ttagcaagag ggcccaggat ttttggatcc ccagccctgt gacaagggtt 180 cctgtccagt ttccccctcc caggatttcg actcagttca gcgaagtcac cgccccgtct 240 gagaaatgag gacaccaagg cttagagcac agccccgagg cgccgtctac caggccccgt 300 cccctccccc ggctcctgtc ggtcagcact gaaaccccgt ccctgctcca ggcctccttc 360 tctggggtcc aaggtcccat acaggcctct gcctcggccg caggcccttc agtcaccgtc 420 gcctcgtctc cctgactgtc cgcaggcctg ggcagc atg gcc gta ttc cgg tcg 474 Met Ala Val Phe Arg Ser 1 5 ggt ctc ctg gtg ctg acg acg ccg ctg gcc tcc cta gcc cct cgc ctg 522 Gly Leu Leu Val Leu Thr Thr Pro Leu Ala Ser Leu Ala Pro Arg Leu 10 15 20 gcc tcc atc ctg acc tcg gcg gcc cgg ctg gtg aat cac aca ctc tat 570 Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu Val Asn His Thr Leu Tyr 25 30 35 gtt cac ctg cag ccg ggc atg agc ctg gag ggc ccg gct cag ccc cag 618 Val His Leu Gln Pro Gly Met Ser Leu Glu Gly Pro Ala Gln Pro Gln 40 45 50 tac agc ccc gtg cag gcc acg ttt gag gtt ctt gat ttc atc acg cac 666 Tyr Ser Pro Val Gln Ala Thr Phe Glu Val Leu Asp Phe Ile Thr His 55 60 65 70 ctc tat gct ggc gcc gac gtc cac agg cac ttg gac gtc aga atc cta 714 Leu Tyr Ala Gly Ala Asp Val His Arg His Leu Asp Val Arg Ile Leu 75 80 85 ctg acc aat atc cga acc aag agc acc ttt ctc cct ccc ctg ccc acc 762 Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe Leu Pro Pro Leu Pro Thr 90 95 100 tca gtc cag aat ctc gcc cac ccg cca gaa gtc gtg ttg aca gat ttc 810 Ser Val Gln Asn Leu Ala His Pro Pro Glu Val Val Leu Thr Asp Phe 105 110 115 cag acc ctg gat gga agc cag tac aac ccg gtc aaa cag cag cta gtg 858 Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro Val Lys Gln Gln Leu Val 120 125 130 cgt tac gcc acc agc tgt tac agc tgt tgt ccg cga ctg gcc tcg gtg 906 Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys Pro Arg Leu Ala Ser Val 135 140 145 150 ctg cta tac tcc gat tat ggg ata gga gaa gtg ccc gtg gag ccc ctg 954 Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu Val Pro Val Glu Pro Leu 155 160 165 gat gtc ccc tta ccc tcc acg atc agg cca gct tcc ccc gtg gcc ggg 1002 Asp Val Pro Leu Pro Ser Thr Ile Arg Pro Ala Ser Pro Val Ala Gly 170 175 180 tct cca aag cag ccg gtg cgt ggc tac tac cgt ggc gct gtc ggt ggc 1050 Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr Arg Gly Ala Val Gly Gly 185 190 195 acg ttt gac cgc ctg cac aac gcc cac aag gtg ttg ctc agt gtc gcg 1098 Thr Phe Asp Arg Leu His Asn Ala His Lys Val Leu Leu Ser Val Ala 200 205 210 tgc atc ctg gcc cag gag cag ctt gtg gtg gga gta gca gac aaa gat 1146 Cys Ile Leu Ala Gln Glu Gln Leu Val Val Gly Val Ala Asp Lys Asp 215 220 225 230 ctg ttg aag agc aag ttg ctc cct gag ctg ctc caa cct tat aca gaa 1194 Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu Leu Gln Pro Tyr Thr Glu 235 240 245 cgt gtg gaa cat ctg agt gaa ttc ctg gtg gac atc aag ccc tcc ttg 1242 Arg Val Glu His Leu Ser Glu Phe Leu Val Asp Ile Lys Pro Ser Leu 250 255 260 act ttt gat gtc atc ccc ctg ctg gac ccc tat ggg ccc gct ggc tct 1290 Thr Phe Asp Val Ile Pro Leu Leu Asp Pro Tyr Gly Pro Ala Gly Ser 265 270 275 gac ccc tcc ctg gag ttc ctg gtg gtc agc gag gag acc tat cgt ggg 1338 Asp Pro Ser Leu Glu Phe Leu Val Val Ser Glu Glu Thr Tyr Arg Gly 280 285 290 ggg atg gcc atc aac cgc ttc cgc ctt gag aat gac ctg gag gaa ctt 1386 Gly Met Ala Ile Asn Arg Phe Arg Leu Glu Asn Asp Leu Glu Glu Leu 295 300 305 310 gct ttg tac caa gat cca gct gct gaa gga cct cag aca tac gga gaa 1434 Ala Leu Tyr Gln Asp Pro Ala Ala Glu Gly Pro Gln Thr Tyr Gly Glu 315 320 325 tgaagaggac aaagtcagct cctccagctt ccgccagcga atgttgggga acctgcttcg 1494 gcctccatat gaaaggccag agctccccac atgtctctat gtaattgggc tgactggcat 1554 cagtggctct gggaagagct caatagctca gcgactgaag ggcctggggg cgtttgtcat 1614 tgacagtgac cacctgggtc atcgggccta tgccccaggt ggccctgcct accagcctgt 1674 ggtggaggcc tttggaacag atattctcca taaagatggc atcatcaaca ggaaggtcct 1734 aggcagccgg gtgtttggga ataagaagca gctgaagata ctcacggaca ttatgtggcc 1794 aattatcgca aagctggccc gagaggagat ggatcgggct gtggctgagg gaaagcgtgt 1854 gtgtgtgatt gatgccgctg tgttgcttga agccggctgg cagaacctgg tccatgaggt 1914 gtggactgct gtcatcccag agactgaggc tgtaagacgc attgtggaga gggatggcct 1974 cagtgaagcc gcggctcaaa gccggctgca gagccagatg agcgggcagc agcttgtgga 2034 acagagccac gtggtgctca gcaccttgtg ggagccgcat atcacccaac gccaggtgga 2094 gaaagcctgg gccctcttgc agaagcgcat tcccaagact catcaggccc tcgactgaaa 2154 agttctcagt ggggccagac tggctcctgg agctgacaag cgaccccgtg gtgaggagaa 2214 atgggggcct tgatgctcac cctggttcag gcccagaggt ccaagctata ctgtgcagga 2274 catggccagg cctggtggac acaggaagcc tacccaacac gctggtattt ggccaacact 2334 gaggatgtgg ttcatggggg agcagtcccc tccccactct tgcccatggg tgactcttac 2394 ccacagctga ctagggccag cgcaaatact ggaacctgta acagaattaa aggtgaatgt 2454 tctgaaaaaa g 2465 <210> 108 <211> 326 <212> PRT <213> Homo sapiens <400> 108 Met Ala Val Phe Arg Ser Gly Leu Leu Val Leu Thr Thr Pro Leu Ala 1 5 10 15 Ser Leu Ala Pro Arg Leu Ala Ser Ile Leu Thr Ser Ala Ala Arg Leu 20 25 30 Val Asn His Thr Leu Tyr Val His Leu Gln Pro Gly Met Ser Leu Glu 35 40 45 Gly Pro Ala Gln Pro Gln Tyr Ser Pro Val Gln Ala Thr Phe Glu Val 50 55 60 Leu Asp Phe Ile Thr His Leu Tyr Ala Gly Ala Asp Val His Arg His 65 70 75 80 Leu Asp Val Arg Ile Leu Leu Thr Asn Ile Arg Thr Lys Ser Thr Phe 85 90 95 Leu Pro Pro Leu Pro Thr Ser Val Gln Asn Leu Ala His Pro Pro Glu 100 105 110 Val Val Leu Thr Asp Phe Gln Thr Leu Asp Gly Ser Gln Tyr Asn Pro 115 120 125 Val Lys Gln Gln Leu Val Arg Tyr Ala Thr Ser Cys Tyr Ser Cys Cys 130 135 140 Pro Arg Leu Ala Ser Val Leu Leu Tyr Ser Asp Tyr Gly Ile Gly Glu 145 150 155 160 Val Pro Val Glu Pro Leu Asp Val Pro Leu Pro Ser Thr Ile Arg Pro 165 170 175 Ala Ser Pro Val Ala Gly Ser Pro Lys Gln Pro Val Arg Gly Tyr Tyr 180 185 190 Arg Gly Ala Val Gly Gly Thr Phe Asp Arg Leu His Asn Ala His Lys 195 200 205 Val Leu Leu Ser Val Ala Cys Ile Leu Ala Gln Glu Gln Leu Val Val 210 215 220 Gly Val Ala Asp Lys Asp Leu Leu Lys Ser Lys Leu Leu Pro Glu Leu 225 230 235 240 Leu Gln Pro Tyr Thr Glu Arg Val Glu His Leu Ser Glu Phe Leu Val 245 250 255 Asp Ile Lys Pro Ser Leu Thr Phe Asp Val Ile Pro Leu Leu Asp Pro 260 265 270 Tyr Gly Pro Ala Gly Ser Asp Pro Ser Leu Glu Phe Leu Val Val Ser 275 280 285 Glu Glu Thr Tyr Arg Gly Gly Met Ala Ile Asn Arg Phe Arg Leu Glu 290 295 300 Asn Asp Leu Glu Glu Leu Ala Leu Tyr Gln Asp Pro Ala Ala Glu Gly 305 310 315 320 Pro Gln Thr Tyr Gly Glu 325 <210> 109 <211> 2557 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (101)..(490) <400> 109 gctaatatgc tccctctccc acaaggcagc gcgccggctc ggacgcggcc ggctaccgag 60 ccctttgtga gagctgtgag ctgcgcctga cggtggcacc atg agc agc tca ggt 115 Met Ser Ser Ser Gly 1 5 ggg gcg ccc ggg gcg tcc gcc agc tct gcg ccg ccc gcg cag gaa gag 163 Gly Ala Pro Gly Ala Ser Ala Ser Ser Ala Pro Pro Ala Gln Glu Glu 10 15 20 ggc atg acg tgg tgg tac cgc tgg ctg tgt cgc ctg tct ggg gtg ctg 211 Gly Met Thr Trp Trp Tyr Arg Trp Leu Cys Arg Leu Ser Gly Val Leu 25 30 35 ggg gca gtc tct tgc gcg atc tct ggc ctc ttc aac tgc atc acc atc 259 Gly Ala Val Ser Cys Ala Ile Ser Gly Leu Phe Asn Cys Ile Thr Ile 40 45 50 cac cct ctg aac atc gcg gcc ggc gtg tgg atg atg atg gcg gtc gtt 307 His Pro Leu Asn Ile Ala Ala Gly Val Trp Met Met Met Ala Val Val 55 60 65 ccc atc gtc atc agc ctg acc ctg acc acg ctg ctg ggc aac gcc atc 355 Pro Ile Val Ile Ser Leu Thr Leu Thr Thr Leu Leu Gly Asn Ala Ile 70 75 80 85 gcc ttt gct acg ggg gtg ctg tac gga ctc tct gct ctg ggc aaa aag 403 Ala Phe Ala Thr Gly Val Leu Tyr Gly Leu Ser Ala Leu Gly Lys Lys 90 95 100 ggc gat gcg atc tcc tat gcc agg atc cag cag cag agg cag cag gcg 451 Gly Asp Ala Ile Ser Tyr Ala Arg Ile Gln Gln Gln Arg Gln Gln Ala 105 110 115 gat gag gag aag ctc gcg gag acc ctg gag ggg gag ctg tgaagggctg 500 Asp Glu Glu Lys Leu Ala Glu Thr Leu Glu Gly Glu Leu 120 125 130 ggcgcccctc cctccctgtc ccctcttctg gctctgtgtg ggtccaagtg aggcctggac 560 tgtccacgct gaggcacagc ctggagaggg gcctttgcac gtgtccctac acctggagtc 620 ctctgctcct ttctccagac tggcttaagc caggagccac tggctgctgg tgtgagggtc 680 tgggctgctg gacttgaggc agagcctgca gcagctgtgt ggacactacc cagccctact 740 cctctgctgg gtgggtctgc agatctcaca ccacagacag ggctgcctgt gacctgctgt 800 gacctgggag cagcttcccc tggagatgct ggtcctggct tgaggggagg ggcaagtggg 860 accctgccac ctgggcactg agcagaggga cctcccccag ctctcttagc aggtggagcc 920 ccagggcctg ggacagcctg ccgctgccag caacctccca ctgctgccta gggtgcagcg 980 cccactgtca ccctgccttc tgaagaagcc cacagggctc ctaaggtgca ccccggtacc 1040 tggaactgca gccttggcag tgactggaca gctgggtggg ggatgctccc tgctggccct 1100 gggaaccttg gacaggccac ctcaaggccc ctcggctgcc cctcctccct gggcctgctg 1160 gggcccctag gttctgccca tcaccccccg cccctgctgg ccttggtgct aaggaagtgg 1220 ggagagcagg ctctccctgg caccgagggt gcccaccctc tccctggtgt ggccccgtca 1280 acatcagcca cagcccagcc ccattagtgg gttagtgggt ctgacctcag ccccactcag 1340 gtgctcctgc tggcctgccc aagccctgcc ctcagggagc ttctgccttt taagaactgg 1400 gcagaggcca cagtcacctc cccacacaga gctgtcccca ctgccctggg tgccaggctg 1460 tccggagcca ggcctaccca gggaggatgc agagagctgg tgcccaggat gtgcaccccc 1520 atattccctc tgccctgtgg cctcagcccg ctggcctctc tgaccgtgag gctggctctc 1580 agccatcggg caggtgcctg gtcgggcctg gcttagccca ggtggggctt ggcagaagcg 1640 ggcgggtgtg gaagatattc catctggggc caaccccagg ctgggcctgc gctgagcttc 1700 tggagcgcag gtactgggtc ttgctaagtg aactgtttcc caggaacacc tctcgggccc 1760 atctgcgtct gaggctggga gtggcatctg aggccgggag tggcatctga ggccaggagt 1820 ggcaggctgg tgggctgggc gtggggtttt ctgggccctg cccagtactg ccctggggac 1880 ttggtgggct cctgggtcag cagcatccca cccctgggag tctggccagc tgagccccag 1940 ggtggcaggg gcattatagc ctggtggact gtgccttcag ggttcctccg gggccacctt 2000 cctcaggcca gtgctgggtt caaagggctg tgtgtgtgtg tgtgtgtgtg tgtgtatgta 2060 tatgtgtgtg ggtgcacaca tctgtcccat gtatgcagtg agacctgtct acctcccaca 2120 aggagcaagg gctctgcccg ccctctgctc attcctaccc aggtagtggg accccgggcc 2180 cccttctgcc tggcttgcct gcttctgccc tttccagagg ggtctcactg acagccagag 2240 acagcaggag aagggttggc tgtggatcaa ggaaggctgc ccctgtaccc tgtggggaaa 2300 tggtgggtgc atggctggat gcagaggtgg aaggccctgg gccacaggcg agagtgggcg 2360 tgtcacctgt cccaggttcc cagcaagtct gcagctgtgc agtcctgggg tccctgaccc 2420 tgtcgcccag ggggcgtgct gtccagcagg ggccctgcct tgcaaggaac gtctcttccg 2480 gcggctgggc cgctcctgcc tggtctgggc tgtgtgtggc gccctttcct ccttgtttgt 2540 tcctctgctc ccttctg 2557 <210> 110 <211> 130 <212> PRT <213> Homo sapiens <400> 110 Met Ser Ser Ser Gly Gly Ala Pro Gly Ala Ser Ala Ser Ser Ala Pro 1 5 10 15 Pro Ala Gln Glu Glu Gly Met Thr Trp Trp Tyr Arg Trp Leu Cys Arg 20 25 30 Leu Ser Gly Val Leu Gly Ala Val Ser Cys Ala Ile Ser Gly Leu Phe 35 40 45 Asn Cys Ile Thr Ile His Pro Leu Asn Ile Ala Ala Gly Val Trp Met 50 55 60 Met Met Ala Val Val Pro Ile Val Ile Ser Leu Thr Leu Thr Thr Leu 65 70 75 80 Leu Gly Asn Ala Ile Ala Phe Ala Thr Gly Val Leu Tyr Gly Leu Ser 85 90 95 Ala Leu Gly Lys Lys Gly Asp Ala Ile Ser Tyr Ala Arg Ile Gln Gln 100 105 110 Gln Arg Gln Gln Ala Asp Glu Glu Lys Leu Ala Glu Thr Leu Glu Gly 115 120 125 Glu Leu 130 <210> 111 <211> 3099 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (118)..(918) <400> 111 ttcaccaacg accagtacta cgtgtacttc ggcaccgtcc gcgactgcta tgaggccttg 60 gtcatctata atttcctgag cctgtgctat gagtacctag gaggagaaag ttccatc 117 atg tcg gag atc aga gga aaa ccc att gag tcc agc tgt atg tat ggc 165 Met Ser Glu Ile Arg Gly Lys Pro Ile Glu Ser Ser Cys Met Tyr Gly 1 5 10 15 acc tgc tgc ctc tgg gga aag act tat tcc atc gga ttt ctg agg ttc 213 Thr Cys Cys Leu Trp Gly Lys Thr Tyr Ser Ile Gly Phe Leu Arg Phe 20 25 30 tgc aaa cag gcc acc ctg cag ttc tgt gtg gtg aag cca ctc atg gcg 261 Cys Lys Gln Ala Thr Leu Gln Phe Cys Val Val Lys Pro Leu Met Ala 35 40 45 gtc agc act gtg gtc ctc cag gcc ttc ggc aag tac cgg gat ggg gac 309 Val Ser Thr Val Val Leu Gln Ala Phe Gly Lys Tyr Arg Asp Gly Asp 50 55 60 ttt gac gtc acc agt ggc tac ctc tac gtg acc atc atc tgc aac atc 357 Phe Asp Val Thr Ser Gly Tyr Leu Tyr Val Thr Ile Ile Cys Asn Ile 65 70 75 80 tcc gtc agc ctg gcc ctc tac gcc ctc ttc ctc ttc tac ttc gcc acc 405 Ser Val Ser Leu Ala Leu Tyr Ala Leu Phe Leu Phe Tyr Phe Ala Thr 85 90 95 cgg gag ctg ctc agc ccc tac agc ccc gtc ctc aag ttc ttc atg gtc 453 Arg Glu Leu Leu Ser Pro Tyr Ser Pro Val Leu Lys Phe Phe Met Val 100 105 110 aag tcc gtc atc ttt ctt tcc ttc tgg caa ggc atg ctc ctg gcc atc 501 Lys Ser Val Ile Phe Leu Ser Phe Trp Gln Gly Met Leu Leu Ala Ile 115 120 125 ctg gag aag tgt ggg gcc atc ccc aaa atc cac tcg gcc cgc gtg tcg 549 Leu Glu Lys Cys Gly Ala Ile Pro Lys Ile His Ser Ala Arg Val Ser 130 135 140 gtg ggc gag ggc acc gtg gct gcc ggc tac cag gac ttc atc atc tgt 597 Val Gly Glu Gly Thr Val Ala Ala Gly Tyr Gln Asp Phe Ile Ile Cys 145 150 155 160 gtg gag atg ttc ttt gca gcc ctg gcc ctg cgg cac gcc ttc acc tac 645 Val Glu Met Phe Phe Ala Ala Leu Ala Leu Arg His Ala Phe Thr Tyr 165 170 175 aag gtc tat gct gac aag agg ctg gac gca caa ggc cgc tgt gcc ccc 693 Lys Val Tyr Ala Asp Lys Arg Leu Asp Ala Gln Gly Arg Cys Ala Pro 180 185 190 atg aag agc atc tcc agc agc ctc aag gag acc atg aac ccg cac gac 741 Met Lys Ser Ile Ser Ser Ser Leu Lys Glu Thr Met Asn Pro His Asp 195 200 205 atc gtg cag gac gcc atc cac aac ttc tca cct gcc tac cag cag tac 789 Ile Val Gln Asp Ala Ile His Asn Phe Ser Pro Ala Tyr Gln Gln Tyr 210 215 220 acg ctg cag tcc acc ctg gag cct ggg ccc acc tgg cgt ggt ggc gcc 837 Thr Leu Gln Ser Thr Leu Glu Pro Gly Pro Thr Trp Arg Gly Gly Ala 225 230 235 240 cac ggc ctc tcc cgc tcc cac agc ctc agt ggc gcc cgc gac aac gag 885 His Gly Leu Ser Arg Ser His Ser Leu Ser Gly Ala Arg Asp Asn Glu 245 250 255 aag act ctc ctg ctc agc tct gat gat gaa ttc taggtgcggg ctgcagtggc 938 Lys Thr Leu Leu Leu Ser Ser Asp Asp Glu Phe 260 265 ggaagtgctg gcgccatagc cacggtcagg ctgtgcccca cctccagcct caccaccagg 998 ccaggaggca gctggcacag tgctcacgcc gcctttattt attggaccag aaacactcac 1058 atgtcacttc cagaggaacg ggggacagcc aggctcgccc atgggccttc aggaatattt 1118 atacatggcc cagcctgcac tgcccgggcg agggcagagg acactgggag caaggcttat 1178 gcccctgctg cccgtcctgt gctgggggca tgctgggacc agccgcaccc aggccccaat 1238 gcttgtgtgt ggaccagcgg ctgcagcctt ctagcccctc ctccccgcga gactctcagg 1298 ctgaggtcgg caagccgtgg ctcccccaca caccgtgcaa taccctgtct gacctgggct 1358 cttcccgcct gcatccctcc cctgtccacc tttgtccagt gctagattca cctcaccccg 1418 ggcaggagtg gggatgtggg cgctctgtgg tcctcccctc ctgacccagg cctctgtggc 1478 atgctgcaag gatcagagcc agacaccagg agtcacaggc cccacccagg aagggcattc 1538 agggcccctg ggcaccgctt ctgttgaagc aggggcttct gggcccctgg gtatccccac 1598 ctgtcgtggc cacacctctg cctgcctcat gccccttccc cctggcctac caaggacagc 1658 ccacagcccg cactgccggc tcacttgggt ccttcctcga tagctttggg cagagccctt 1718 gcttcctggc tgcttcaggg ctcaggggct cccagccctc cttcccaggc tgatgctggg 1778 tcctctctct ctttggggct tctccctccc gtttcagggg aaaggtctga gtctccacgt 1838 ttcagaccag cttctggggg aaggcagtcc ggcagggaga ccgggagggg tggccacaca 1898 gtggggagct gggaggtggg gggaatggtc ccagactcct ctcggggccc ctatccacac 1958 agggcctggt gttctacccc atctggcccc tggcccatct cttctgtgcc ttagtcacat 2018 atgaaagcgc ccctccctgg ctccccatct gtcccacacg ctccctgggg ctcttagttc 2078 agctgctggc actcgcagga tcctgcagtg ctgggcccag agcccttgga caggcctcag 2138 gagtggtcag gaccaccaag cccctcctct ccccctccac acctctagac ctggggcctc 2198 cggaaccccc agcaggctgg gcttatacta gctcctgact taggaagagc ctcgtgtcac 2258 aacacgtgtc cctacaggca aagtgtcctg gcatttaaaa cccagattat ccctgggttt 2318 gggctgcagt cacctggaga agctggtagg gtaagggaga gggaccctgc cggtgttcac 2378 tggggattct ttcttttggt ccttcctgga atgaacaggt tccctccctg ccacctgtga 2438 ggagagttgg ggcccagccg tcttcctggc ctccttcctt tcctcgtggc agaggcctgc 2498 atgtgggtgc cagaggccag ctctccccct ccatcttggg ggggcggagc agttgggccc 2558 aagctgcccg ggagggtggg tgcagacaca ggctgaggac cagccctggc cctgccccgc 2618 catctgcttt caccaagctg tctctccacc gtggcttccc ttctccctcc aggccaaagt 2678 gctgctgatt cccactccct tggttttcgc ctgcccagcg ttgctgtttg cgtggagggt 2738 ggggggagct cagtggcagg gaatcagcgg tccgtggggt cgtggggacg ggaacatgtg 2798 cccgaccgct ccatcccctc ctcctcctta ggatgcataa cctaccttgt cttttttttt 2858 ttaaattttc tttccaggta gagtagctct ttgtacataa agaatacttg aaaaattaat 2918 tgtatgatgt atgagaagac agagtctcct agttttgtat cttgttgtat gactgccatg 2978 agttccacca gaaagccact ctattttggt ctctgtgaca ttttaaatgc gtgacagaag 3038 tgagcaaata aagtgaggaa gaaatctata tatgagataa tatagattgt attgaaatct 3098 c 3099 <210> 112 <211> 267 <212> PRT <213> Homo sapiens <400> 112 Met Ser Glu Ile Arg Gly Lys Pro Ile Glu Ser Ser Cys Met Tyr Gly 1 5 10 15 Thr Cys Cys Leu Trp Gly Lys Thr Tyr Ser Ile Gly Phe Leu Arg Phe 20 25 30 Cys Lys Gln Ala Thr Leu Gln Phe Cys Val Val Lys Pro Leu Met Ala 35 40 45 Val Ser Thr Val Val Leu Gln Ala Phe Gly Lys Tyr Arg Asp Gly Asp 50 55 60 Phe Asp Val Thr Ser Gly Tyr Leu Tyr Val Thr Ile Ile Cys Asn Ile 65 70 75 80 Ser Val Ser Leu Ala Leu Tyr Ala Leu Phe Leu Phe Tyr Phe Ala Thr 85 90 95 Arg Glu Leu Leu Ser Pro Tyr Ser Pro Val Leu Lys Phe Phe Met Val 100 105 110 Lys Ser Val Ile Phe Leu Ser Phe Trp Gln Gly Met Leu Leu Ala Ile 115 120 125 Leu Glu Lys Cys Gly Ala Ile Pro Lys Ile His Ser Ala Arg Val Ser 130 135 140 Val Gly Glu Gly Thr Val Ala Ala Gly Tyr Gln Asp Phe Ile Ile Cys 145 150 155 160 Val Glu Met Phe Phe Ala Ala Leu Ala Leu Arg His Ala Phe Thr Tyr 165 170 175 Lys Val Tyr Ala Asp Lys Arg Leu Asp Ala Gln Gly Arg Cys Ala Pro 180 185 190 Met Lys Ser Ile Ser Ser Ser Leu Lys Glu Thr Met Asn Pro His Asp 195 200 205 Ile Val Gln Asp Ala Ile His Asn Phe Ser Pro Ala Tyr Gln Gln Tyr 210 215 220 Thr Leu Gln Ser Thr Leu Glu Pro Gly Pro Thr Trp Arg Gly Gly Ala 225 230 235 240 His Gly Leu Ser Arg Ser His Ser Leu Ser Gly Ala Arg Asp Asn Glu 245 250 255 Lys Thr Leu Leu Leu Ser Ser Asp Asp Glu Phe 260 265 <210> 113 <211> 2563 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (31)..(2238) <400> 113 gctggcggtt ccgttaggtc tgagggagcg atg gcg gta cgc gcg ttg aag ctg 54 Met Ala Val Arg Ala Leu Lys Leu 1 5 ctg acc aca ctg ctg gct gtc gtg gcc gct gcc tcc caa gcc gag gtc 102 Leu Thr Thr Leu Leu Ala Val Val Ala Ala Ala Ser Gln Ala Glu Val 10 15 20 gag tcc gag gca gga tgg ggc atg gtg acg cct gat ctg ctc ttc gcc 150 Glu Ser Glu Ala Gly Trp Gly Met Val Thr Pro Asp Leu Leu Phe Ala 25 30 35 40 gag ggg acc gca gcc tac gcg cgc ggg gac tgg ccc ggg gtg gtc ctg 198 Glu Gly Thr Ala Ala Tyr Ala Arg Gly Asp Trp Pro Gly Val Val Leu 45 50 55 agc atg gaa cgg gcg ctg cgc tcc cgg gca gcc ctc cgc gcc ctt cgc 246 Ser Met Glu Arg Ala Leu Arg Ser Arg Ala Ala Leu Arg Ala Leu Arg 60 65 70 ctg cgc tgc cgc acc cag tgt gcc gcc gac ttc ccg tgg gag ctg gac 294 Leu Arg Cys Arg Thr Gln Cys Ala Ala Asp Phe Pro Trp Glu Leu Asp 75 80 85 ccc gac tgg tcc ccc agc ccg gcc cag gcc tcg ggc gcc gcc gcc ctg 342 Pro Asp Trp Ser Pro Ser Pro Ala Gln Ala Ser Gly Ala Ala Ala Leu 90 95 100 cgc gac ctg agc ttc ttc ggg ggc ctt ctg cgt cgc gct gcc tgc ctg 390 Arg Asp Leu Ser Phe Phe Gly Gly Leu Leu Arg Arg Ala Ala Cys Leu 105 110 115 120 cgc cgc tgc ctc ggg ccg ccg gcc gcc cac tcg ctc agc gaa gag atg 438 Arg Arg Cys Leu Gly Pro Pro Ala Ala His Ser Leu Ser Glu Glu Met 125 130 135 gag ctg gag ttc cgc aag cgg agc ccc tac aac tac ctg cag gtc gcc 486 Glu Leu Glu Phe Arg Lys Arg Ser Pro Tyr Asn Tyr Leu Gln Val Ala 140 145 150 tac ttc aag atc aac aag ttg gag aaa gct gtt gct gca gca cac acc 534 Tyr Phe Lys Ile Asn Lys Leu Glu Lys Ala Val Ala Ala Ala His Thr 155 160 165 ttc ttc gtg ggc aat cct gag cac atg gaa atg cag cag aac cta gac 582 Phe Phe Val Gly Asn Pro Glu His Met Glu Met Gln Gln Asn Leu Asp 170 175 180 tat tac caa acc atg tct gga gtg aag gag gcc gac ttc aag gat ctt 630 Tyr Tyr Gln Thr Met Ser Gly Val Lys Glu Ala Asp Phe Lys Asp Leu 185 190 195 200 gag act caa ccc cat atg caa gaa ttt cga ctg gga gtg cga ctc tac 678 Glu Thr Gln Pro His Met Gln Glu Phe Arg Leu Gly Val Arg Leu Tyr 205 210 215 tca gag gaa cag cca cag gaa gct gtg ccc cac cta gag gcg gcg ctg 726 Ser Glu Glu Gln Pro Gln Glu Ala Val Pro His Leu Glu Ala Ala Leu 220 225 230 caa gaa tac ttt gtg gcc tat gag gag tgc cgt gcc ctc tgc gaa ggg 774 Gln Glu Tyr Phe Val Ala Tyr Glu Glu Cys Arg Ala Leu Cys Glu Gly 235 240 245 ccc tat gac tac gat ggc tac aac tac ctt gag tac aac gct gac ctc 822 Pro Tyr Asp Tyr Asp Gly Tyr Asn Tyr Leu Glu Tyr Asn Ala Asp Leu 250 255 260 ttc cag gcc atc aca gat cat tac atc cag gtc ctc aac tgt aag cag 870 Phe Gln Ala Ile Thr Asp His Tyr Ile Gln Val Leu Asn Cys Lys Gln 265 270 275 280 aac tgt gtc acg gag ctt gct tcc cac cca agt cga gag aag ccc ttt 918 Asn Cys Val Thr Glu Leu Ala Ser His Pro Ser Arg Glu Lys Pro Phe 285 290 295 gaa gac ttc ctc cca tcg cat tat aat tat ctg cag ttt gcc tac tat 966 Glu Asp Phe Leu Pro Ser His Tyr Asn Tyr Leu Gln Phe Ala Tyr Tyr 300 305 310 aac att ggg aat tat aca cag gct gtt gaa tgt gcc aag acc tat ctt 1014 Asn Ile Gly Asn Tyr Thr Gln Ala Val Glu Cys Ala Lys Thr Tyr Leu 315 320 325 ctc ttc ttc ccc aat gac gag gtg atg aac caa aat ttg gcc tat tat 1062 Leu Phe Phe Pro Asn Asp Glu Val Met Asn Gln Asn Leu Ala Tyr Tyr 330 335 340 gca gct atg ctt gga gaa gaa cac acc aga tcc atc ggc ccc cgt gag 1110 Ala Ala Met Leu Gly Glu Glu His Thr Arg Ser Ile Gly Pro Arg Glu 345 350 355 360 agt gcc aag gag tac cga cag cga agc cta ctg gaa aaa gaa ctg ctt 1158 Ser Ala Lys Glu Tyr Arg Gln Arg Ser Leu Leu Glu Lys Glu Leu Leu 365 370 375 ttc ttc gct tat gat gtt ttt gga att ccc ttt gtg gat ccg gat tca 1206 Phe Phe Ala Tyr Asp Val Phe Gly Ile Pro Phe Val Asp Pro Asp Ser 380 385 390 tgg act cca gaa gaa gtg att ccc aag aga ttg caa gag aaa cag aag 1254 Trp Thr Pro Glu Glu Val Ile Pro Lys Arg Leu Gln Glu Lys Gln Lys 395 400 405 tca gaa cgg gaa aca gcc gta cgc atc tcc cag gag att ggg aac ctt 1302 Ser Glu Arg Glu Thr Ala Val Arg Ile Ser Gln Glu Ile Gly Asn Leu 410 415 420 atg aag gaa atc gag acc ctt gtg gaa gag aag acc aag gag tca ctg 1350 Met Lys Glu Ile Glu Thr Leu Val Glu Glu Lys Thr Lys Glu Ser Leu 425 430 435 440 gat gtg agc aga ctg acc cgg gaa ggt ggc ccc ctg ctg tat gaa ggc 1398 Asp Val Ser Arg Leu Thr Arg Glu Gly Gly Pro Leu Leu Tyr Glu Gly 445 450 455 atc agt ctc acc atg aac tcc aaa ctc ctg aat ggt tcc cag cgg gtg 1446 Ile Ser Leu Thr Met Asn Ser Lys Leu Leu Asn Gly Ser Gln Arg Val 460 465 470 gtg atg gac ggc gta atc tct gac cac gag tgt cag gag ctg cag aga 1494 Val Met Asp Gly Val Ile Ser Asp His Glu Cys Gln Glu Leu Gln Arg 475 480 485 ctg acc aat gtg gca gca acc tca gga gat ggc tac cgg ggt cag acc 1542 Leu Thr Asn Val Ala Ala Thr Ser Gly Asp Gly Tyr Arg Gly Gln Thr 490 495 500 tcc cca cat act ccc aat gaa aag ttc tat ggt gtc act gtc ttc aaa 1590 Ser Pro His Thr Pro Asn Glu Lys Phe Tyr Gly Val Thr Val Phe Lys 505 510 515 520 gcc ctc aag ctg ggg caa gaa ggc aaa gtt cct ctg cag agt gcc cac 1638 Ala Leu Lys Leu Gly Gln Glu Gly Lys Val Pro Leu Gln Ser Ala His 525 530 535 ctg tac tac aac gtg acg gag aag gtg cgg cgc atc atg gag tcc tac 1686 Leu Tyr Tyr Asn Val Thr Glu Lys Val Arg Arg Ile Met Glu Ser Tyr 540 545 550 ttc cgc ctg gat acg ccc ctc tac ttt tcc tac tct cat ctg gtg tgc 1734 Phe Arg Leu Asp Thr Pro Leu Tyr Phe Ser Tyr Ser His Leu Val Cys 555 560 565 cgc act gcc atc gaa gag gtc cag gca gag agg aag gat gat agt cat 1782 Arg Thr Ala Ile Glu Glu Val Gln Ala Glu Arg Lys Asp Asp Ser His 570 575 580 cca gtc cac gtg gac aac tgc atc ctg aat gcc gag acc ctc gtg tgt 1830 Pro Val His Val Asp Asn Cys Ile Leu Asn Ala Glu Thr Leu Val Cys 585 590 595 600 gtc aaa gag ccc cca gcc tac acc ttc cgc gac tac agc gcc atc ctt 1878 Val Lys Glu Pro Pro Ala Tyr Thr Phe Arg Asp Tyr Ser Ala Ile Leu 605 610 615 tac cta aat ggg gac ttc gat ggc gga aac ttt tat ttc act gaa ctg 1926 Tyr Leu Asn Gly Asp Phe Asp Gly Gly Asn Phe Tyr Phe Thr Glu Leu 620 625 630 gat gcc aag acc gtg acg gca gag gtg cag cct cag tgt gga aga gcc 1974 Asp Ala Lys Thr Val Thr Ala Glu Val Gln Pro Gln Cys Gly Arg Ala 635 640 645 gtg gga ttc tct tca ggc act gaa aac cca cat gga gtg aag gct gtc 2022 Val Gly Phe Ser Ser Gly Thr Glu Asn Pro His Gly Val Lys Ala Val 650 655 660 acc agg ggg cag cgc tgt gcc atc gcc ctg tgg ttc acc ctg gac cct 2070 Thr Arg Gly Gln Arg Cys Ala Ile Ala Leu Trp Phe Thr Leu Asp Pro 665 670 675 680 cga cac agc gag cgg gac agg gtg cag gca gat gac ctg gtg aag atg 2118 Arg His Ser Glu Arg Asp Arg Val Gln Ala Asp Asp Leu Val Lys Met 685 690 695 ctc ttc agc cca gaa gag atg gac ctc tcc cag gag cag ccc ctg gat 2166 Leu Phe Ser Pro Glu Glu Met Asp Leu Ser Gln Glu Gln Pro Leu Asp 700 705 710 gcc cag cag ggc ccc ccc gaa cct gca caa gag tct ctc tca ggc agt 2214 Ala Gln Gln Gly Pro Pro Glu Pro Ala Gln Glu Ser Leu Ser Gly Ser 715 720 725 gaa tcg aag ccc aag gat gag cta tgacagcgtc caggtcagac ggatgggtga 2268 Glu Ser Lys Pro Lys Asp Glu Leu 730 735 ctagacccat ggagaggaac tcttctgcac tctgagctgg ccagcccctc ggggctgcag 2328 agcagtgagc ctacatctgc cactcagccg aggggaccct gctcacagcc ttctacatgg 2388 tgctactgct cttggagtgg acatgaccag acaccgcacc ccctggatct ggctgagggc 2448 tcaggacaca ggcccagcca cccccagggg cctccacagg ccgctgcata acagcgatac 2508 agtacttaag tgtctgtgta gacaaccaaa gaataaatga ttcatggttt ttttt 2563 <210> 114 <211> 736 <212> PRT <213> Homo sapiens <400> 114 Met Ala Val Arg Ala Leu Lys Leu Leu Thr Thr Leu Leu Ala Val Val 1 5 10 15 Ala Ala Ala Ser Gln Ala Glu Val Glu Ser Glu Ala Gly Trp Gly Met 20 25 30 Val Thr Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg 35 40 45 Gly Asp Trp Pro Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser 50 55 60 Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Gln Cys Ala 65 70 75 80 Ala Asp Phe Pro Trp Glu Leu Asp Pro Asp Trp Ser Pro Ser Pro Ala 85 90 95 Gln Ala Ser Gly Ala Ala Ala Leu Arg Asp Leu Ser Phe Phe Gly Gly 100 105 110 Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Pro Ala 115 120 125 Ala His Ser Leu Ser Glu Glu Met Glu Leu Glu Phe Arg Lys Arg Ser 130 135 140 Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Ile Asn Lys Leu Glu 145 150 155 160 Lys Ala Val Ala Ala Ala His Thr Phe Phe Val Gly Asn Pro Glu His 165 170 175 Met Glu Met Gln Gln Asn Leu Asp Tyr Tyr Gln Thr Met Ser Gly Val 180 185 190 Lys Glu Ala Asp Phe Lys Asp Leu Glu Thr Gln Pro His Met Gln Glu 195 200 205 Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu Glu Gln Pro Gln Glu Ala 210 215 220 Val Pro His Leu Glu Ala Ala Leu Gln Glu Tyr Phe Val Ala Tyr Glu 225 230 235 240 Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr Asp Tyr Asp Gly Tyr Asn 245 250 255 Tyr Leu Glu Tyr Asn Ala Asp Leu Phe Gln Ala Ile Thr Asp His Tyr 260 265 270 Ile Gln Val Leu Asn Cys Lys Gln Asn Cys Val Thr Glu Leu Ala Ser 275 280 285 His Pro Ser Arg Glu Lys Pro Phe Glu Asp Phe Leu Pro Ser His Tyr 290 295 300 Asn Tyr Leu Gln Phe Ala Tyr Tyr Asn Ile Gly Asn Tyr Thr Gln Ala 305 310 315 320 Val Glu Cys Ala Lys Thr Tyr Leu Leu Phe Phe Pro Asn Asp Glu Val 325 330 335 Met Asn Gln Asn Leu Ala Tyr Tyr Ala Ala Met Leu Gly Glu Glu His 340 345 350 Thr Arg Ser Ile Gly Pro Arg Glu Ser Ala Lys Glu Tyr Arg Gln Arg 355 360 365 Ser Leu Leu Glu Lys Glu Leu Leu Phe Phe Ala Tyr Asp Val Phe Gly 370 375 380 Ile Pro Phe Val Asp Pro Asp Ser Trp Thr Pro Glu Glu Val Ile Pro 385 390 395 400 Lys Arg Leu Gln Glu Lys Gln Lys Ser Glu Arg Glu Thr Ala Val Arg 405 410 415 Ile Ser Gln Glu Ile Gly Asn Leu Met Lys Glu Ile Glu Thr Leu Val 420 425 430 Glu Glu Lys Thr Lys Glu Ser Leu Asp Val Ser Arg Leu Thr Arg Glu 435 440 445 Gly Gly Pro Leu Leu Tyr Glu Gly Ile Ser Leu Thr Met Asn Ser Lys 450 455 460 Leu Leu Asn Gly Ser Gln Arg Val Val Met Asp Gly Val Ile Ser Asp 465 470 475 480 His Glu Cys Gln Glu Leu Gln Arg Leu Thr Asn Val Ala Ala Thr Ser 485 490 495 Gly Asp Gly Tyr Arg Gly Gln Thr Ser Pro His Thr Pro Asn Glu Lys 500 505 510 Phe Tyr Gly Val Thr Val Phe Lys Ala Leu Lys Leu Gly Gln Glu Gly 515 520 525 Lys Val Pro Leu Gln Ser Ala His Leu Tyr Tyr Asn Val Thr Glu Lys 530 535 540 Val Arg Arg Ile Met Glu Ser Tyr Phe Arg Leu Asp Thr Pro Leu Tyr 545 550 555 560 Phe Ser Tyr Ser His Leu Val Cys Arg Thr Ala Ile Glu Glu Val Gln 565 570 575 Ala Glu Arg Lys Asp Asp Ser His Pro Val His Val Asp Asn Cys Ile 580 585 590 Leu Asn Ala Glu Thr Leu Val Cys Val Lys Glu Pro Pro Ala Tyr Thr 595 600 605 Phe Arg Asp Tyr Ser Ala Ile Leu Tyr Leu Asn Gly Asp Phe Asp Gly 610 615 620 Gly Asn Phe Tyr Phe Thr Glu Leu Asp Ala Lys Thr Val Thr Ala Glu 625 630 635 640 Val Gln Pro Gln Cys Gly Arg Ala Val Gly Phe Ser Ser Gly Thr Glu 645 650 655 Asn Pro His Gly Val Lys Ala Val Thr Arg Gly Gln Arg Cys Ala Ile 660 665 670 Ala Leu Trp Phe Thr Leu Asp Pro Arg His Ser Glu Arg Asp Arg Val 675 680 685 Gln Ala Asp Asp Leu Val Lys Met Leu Phe Ser Pro Glu Glu Met Asp 690 695 700 Leu Ser Gln Glu Gln Pro Leu Asp Ala Gln Gln Gly Pro Pro Glu Pro 705 710 715 720 Ala Gln Glu Ser Leu Ser Gly Ser Glu Ser Lys Pro Lys Asp Glu Leu 725 730 735 <210> 115 <211> 2179 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (56)..(1087) <400> 115 gcacttcagc ttcccccccc ccggcgccct ctggggctcc gagcccggcg ggacc atg 58 Met 1 ttc acc agc acc ggc tcc agt ggg ctc tac aag gcg cct ctg tcg aag 106 Phe Thr Ser Thr Gly Ser Ser Gly Leu Tyr Lys Ala Pro Leu Ser Lys 5 10 15 agc ctt ctg ctg gtc ccc agt gcc ctc tcc ctc ctg ctc gcc ctc ctc 154 Ser Leu Leu Leu Val Pro Ser Ala Leu Ser Leu Leu Leu Ala Leu Leu 20 25 30 ctg cct cac tgc cag aag ctc ttt gtg tat gac ctt cac gca gtc aag 202 Leu Pro His Cys Gln Lys Leu Phe Val Tyr Asp Leu His Ala Val Lys 35 40 45 aac gac ttc cag att tgg agg ttg ata tgt gga aga ata att tgc ctt 250 Asn Asp Phe Gln Ile Trp Arg Leu Ile Cys Gly Arg Ile Ile Cys Leu 50 55 60 65 gat ttg aaa gat act ttc tgc agt agt ctg ctt att tat aat ttt agg 298 Asp Leu Lys Asp Thr Phe Cys Ser Ser Leu Leu Ile Tyr Asn Phe Arg 70 75 80 ata ttt gaa aga aga tat gga agc aga aaa ttt gca tcc ttt ttg ctg 346 Ile Phe Glu Arg Arg Tyr Gly Ser Arg Lys Phe Ala Ser Phe Leu Leu 85 90 95 ggt tcc tgg gtt ttg tca gcc tta ttt gac ttt ctc ctc att gaa gct 394 Gly Ser Trp Val Leu Ser Ala Leu Phe Asp Phe Leu Leu Ile Glu Ala 100 105 110 atg cag tat ttc ttt ggc atc act gca gct agt aat ttg cct tct gga 442 Met Gln Tyr Phe Phe Gly Ile Thr Ala Ala Ser Asn Leu Pro Ser Gly 115 120 125 ttc ctg gca cct gtg ttt gct ctg ttt gta cca ttt tac tgc tcc ata 490 Phe Leu Ala Pro Val Phe Ala Leu Phe Val Pro Phe Tyr Cys Ser Ile 130 135 140 145 cca aga gtc caa gtg gca caa att ctg ggt ccg ttg tcc atc aca aac 538 Pro Arg Val Gln Val Ala Gln Ile Leu Gly Pro Leu Ser Ile Thr Asn 150 155 160 aag aca ttg att tat ata ttg gga ctg cag ctt ttc acc tct ggt tcc 586 Lys Thr Leu Ile Tyr Ile Leu Gly Leu Gln Leu Phe Thr Ser Gly Ser 165 170 175 tac atc tgg att gta gcc ata agt gga ctt atg tcc ggt ctg tgc tac 634 Tyr Ile Trp Ile Val Ala Ile Ser Gly Leu Met Ser Gly Leu Cys Tyr 180 185 190 gac agc aaa atg ttc cag gtg cat cag gtg ctc tgc atc ccc agc tgg 682 Asp Ser Lys Met Phe Gln Val His Gln Val Leu Cys Ile Pro Ser Trp 195 200 205 atg gca aaa ttc ttt tct tgg aca ctt gaa ccc atc ttc tct tct tca 730 Met Ala Lys Phe Phe Ser Trp Thr Leu Glu Pro Ile Phe Ser Ser Ser 210 215 220 225 gaa ccc acc agc gaa gcc aga att ggg atg gga gcc acg ctg gac atc 778 Glu Pro Thr Ser Glu Ala Arg Ile Gly Met Gly Ala Thr Leu Asp Ile 230 235 240 cag aga cag cag aga atg gag ctg ctg gac cgg cag ctg atg ttc tct 826 Gln Arg Gln Gln Arg Met Glu Leu Leu Asp Arg Gln Leu Met Phe Ser 245 250 255 cag ttt gca caa ggg agg cga cag aga cag cag cag gga gga atg atc 874 Gln Phe Ala Gln Gly Arg Arg Gln Arg Gln Gln Gln Gly Gly Met Ile 260 265 270 aat tgg aat cgt ctt ttt cct cct tta cgt cag cga caa aac gta aac 922 Asn Trp Asn Arg Leu Phe Pro Pro Leu Arg Gln Arg Gln Asn Val Asn 275 280 285 tat cag ggc ggt cgg cag tct gag cca gca gcg ccc cct cta gaa gtt 970 Tyr Gln Gly Gly Arg Gln Ser Glu Pro Ala Ala Pro Pro Leu Glu Val 290 295 300 305 tct gag gaa cag gtc gcc cgg ctc atg gag atg gga ttt tcc aga ggt 1018 Ser Glu Glu Gln Val Ala Arg Leu Met Glu Met Gly Phe Ser Arg Gly 310 315 320 gat gct ttg gaa gcc ctg aga gct tca aac aat gac ctc aat gtc gcc 1066 Asp Ala Leu Glu Ala Leu Arg Ala Ser Asn Asn Asp Leu Asn Val Ala 325 330 335 acc aac ttc ctg ctg cag cac tgatagtccc aggccaacac tgggaccgga 1117 Thr Asn Phe Leu Leu Gln His 340 ccggcagccg agtgacagtg cgtggtcccc accatcagat cagcccgggg accgagcatc 1177 tctggtgctg atgttcttgt gggaagaggg aggttccacc gcacccctgc cctcaaccgc 1237 aagactgttg ccgttttagt gtggagataa gtttgccatt acattagcat gtattttcta 1297 tctatatttt ttattgggca ttttccctag gttggagagt cagcactcgt tttgaatgtg 1357 tttaaaatgc attaaaatgg aagatttctg caggcagttg aatggcactc cagatgggga 1417 attgctgtaa ccctcttact gtaacatgtc atctcctgcg tcgtgatggg gagagggtaa 1477 tgttacttca caaaggacat gtcagatcct tcttcatgga cttttttagt tactgttttt 1537 tctctcaaac ttgttttcga atctcctggg agtgagggag aaacagggag ctgaatcctc 1597 ccccaagctg ttccaggcca gaggactctg cagtaccttc tcctacatct agtaacaaag 1657 aatggtgata accatgcact ggttcaaggt tctggagttc tccatgaaac ttgggttaat 1717 tttgctcaga gtatccggag ttagccacta ggctgcgggt gaaatgggat ggagtagaac 1777 aacagcaggc ttcctggagc cacatgggct gactagggca ctctgtggct ggcctggcac 1837 gggctcagcc caggaagagg agaaacgatc ccttgcctgc ccctccctgt ggcagggcta 1897 actgcctggc cctcctggct cgcagccagc cagccccctg gcagcaggtt ctcctcaggg 1957 cttgggtctt caacctgtgg cgacaggagg cagggcagac tgtggaggac aggatgcagg 2017 tcagggagag ggaaggcagg ggtggaccgc catgagcatg aaaagacccg aagcaagttg 2077 actcttgcaa tgtgcaactg ttatgttctg caaaatgagc aacgatgtat caaattgatg 2137 caaatttaga tgttgatact tacaataaag tttttaatgt gt 2179 <210> 116 <211> 344 <212> PRT <213> Homo sapiens <400> 116 Met Phe Thr Ser Thr Gly Ser Ser Gly Leu Tyr Lys Ala Pro Leu Ser 1 5 10 15 Lys Ser Leu Leu Leu Val Pro Ser Ala Leu Ser Leu Leu Leu Ala Leu 20 25 30 Leu Leu Pro His Cys Gln Lys Leu Phe Val Tyr Asp Leu His Ala Val 35 40 45 Lys Asn Asp Phe Gln Ile Trp Arg Leu Ile Cys Gly Arg Ile Ile Cys 50 55 60 Leu Asp Leu Lys Asp Thr Phe Cys Ser Ser Leu Leu Ile Tyr Asn Phe 65 70 75 80 Arg Ile Phe Glu Arg Arg Tyr Gly Ser Arg Lys Phe Ala Ser Phe Leu 85 90 95 Leu Gly Ser Trp Val Leu Ser Ala Leu Phe Asp Phe Leu Leu Ile Glu 100 105 110 Ala Met Gln Tyr Phe Phe Gly Ile Thr Ala Ala Ser Asn Leu Pro Ser 115 120 125 Gly Phe Leu Ala Pro Val Phe Ala Leu Phe Val Pro Phe Tyr Cys Ser 130 135 140 Ile Pro Arg Val Gln Val Ala Gln Ile Leu Gly Pro Leu Ser Ile Thr 145 150 155 160 Asn Lys Thr Leu Ile Tyr Ile Leu Gly Leu Gln Leu Phe Thr Ser Gly 165 170 175 Ser Tyr Ile Trp Ile Val Ala Ile Ser Gly Leu Met Ser Gly Leu Cys 180 185 190 Tyr Asp Ser Lys Met Phe Gln Val His Gln Val Leu Cys Ile Pro Ser 195 200 205 Trp Met Ala Lys Phe Phe Ser Trp Thr Leu Glu Pro Ile Phe Ser Ser 210 215 220 Ser Glu Pro Thr Ser Glu Ala Arg Ile Gly Met Gly Ala Thr Leu Asp 225 230 235 240 Ile Gln Arg Gln Gln Arg Met Glu Leu Leu Asp Arg Gln Leu Met Phe 245 250 255 Ser Gln Phe Ala Gln Gly Arg Arg Gln Arg Gln Gln Gln Gly Gly Met 260 265 270 Ile Asn Trp Asn Arg Leu Phe Pro Pro Leu Arg Gln Arg Gln Asn Val 275 280 285 Asn Tyr Gln Gly Gly Arg Gln Ser Glu Pro Ala Ala Pro Pro Leu Glu 290 295 300 Val Ser Glu Glu Gln Val Ala Arg Leu Met Glu Met Gly Phe Ser Arg 305 310 315 320 Gly Asp Ala Leu Glu Ala Leu Arg Ala Ser Asn Asn Asp Leu Asn Val 325 330 335 Ala Thr Asn Phe Leu Leu Gln His 340 <210> 117 <211> 3362 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (206)..(829) <400> 117 cccgccgccc cggctgcgca cgcgacgccc cctccaggcc ccgctcctgc gccctatttg 60 gtcattcggg gggcaagcgg cgggagggga aacgtgcgcg gccgaagggg aagcggagcc 120 ggcgccggct gcgcagagga gccgctctcg ccgccgccac ctcggctggg agcccacgag 180 gctgccgcat cctgccctcg gaaca atg gga ctc ggc gcg cga ggt gct tgg 232 Met Gly Leu Gly Ala Arg Gly Ala Trp 1 5 gcc gcg ctg ctc ctg ggg acg ctg cag gtg cta gcg ctg ctg ggg gcc 280 Ala Ala Leu Leu Leu Gly Thr Leu Gln Val Leu Ala Leu Leu Gly Ala 10 15 20 25 gcc cat gaa agc gca gcc atg gcg gca tct gca aac ata gag aat tct 328 Ala His Glu Ser Ala Ala Met Ala Ala Ser Ala Asn Ile Glu Asn Ser 30 35 40 ggg ctt cca cac aac tcc agt gct aac tca aca gag act ctc caa cat 376 Gly Leu Pro His Asn Ser Ser Ala Asn Ser Thr Glu Thr Leu Gln His 45 50 55 gtg cct tct gac cat aca aat gaa act tcc aac agt act gtg aaa cca 424 Val Pro Ser Asp His Thr Asn Glu Thr Ser Asn Ser Thr Val Lys Pro 60 65 70 cca act tca gtt gcc tca gac tcc agt aat aca acg gtc acc acc atg 472 Pro Thr Ser Val Ala Ser Asp Ser Ser Asn Thr Thr Val Thr Thr Met 75 80 85 aaa cct aca gcg gca tct aat aca aca aca cca ggg atg gtc tca aca 520 Lys Pro Thr Ala Ala Ser Asn Thr Thr Thr Pro Gly Met Val Ser Thr 90 95 100 105 aat atg act tct acc acc tta aag tct aca ccc aaa aca aca agt gtt 568 Asn Met Thr Ser Thr Thr Leu Lys Ser Thr Pro Lys Thr Thr Ser Val 110 115 120 tca cag aac aca tct cag ata tca aca tcc aca atg acc gta acc cac 616 Ser Gln Asn Thr Ser Gln Ile Ser Thr Ser Thr Met Thr Val Thr His 125 130 135 aat agt tca gtg aca tct gct gct tca tca gta aca atc aca aca act 664 Asn Ser Ser Val Thr Ser Ala Ala Ser Ser Val Thr Ile Thr Thr Thr 140 145 150 atg cat tct gaa gca aag aaa gga tca aaa ttt gat act ggg agc ttt 712 Met His Ser Glu Ala Lys Lys Gly Ser Lys Phe Asp Thr Gly Ser Phe 155 160 165 gtt ggt ggt att gta tta acg ctg gga gtt tta tct att ctt tac att 760 Val Gly Gly Ile Val Leu Thr Leu Gly Val Leu Ser Ile Leu Tyr Ile 170 175 180 185 gga tgc aaa atg tat tac tca aga aga ggc att cgg tat cga acc ata 808 Gly Cys Lys Met Tyr Tyr Ser Arg Arg Gly Ile Arg Tyr Arg Thr Ile 190 195 200 gat gaa cat gat gcc atc att taaggaaatc catggaccaa ggatggaata 859 Asp Glu His Asp Ala Ile Ile 205 cagattgatg ctgccctatc aattaatttt ggtttattaa tagtttaaaa caatattctc 919 tttttgaaaa tagtataaac aggccatgca tataatgtac agtgtattac gtaaatatgt 979 aaagattctt caaggtaaca agggtttggg ttttgaaata aacatctgga tcttatagac 1039 cgttcataca atggttttag caagttcata gtaagacaaa caagtcctat cttttttttt 1099 ttggctgggg tgggggcatt ggtcacatat gaccagtaat tgaaagacgt catcactgaa 1159 agacagaatg ccatctgggc atacaaataa gaagtttgtc acagcactca ggattttggg 1219 tatcttttgt agctcacata aagaacttca gtgcttttca gagctggata tatcttaatt 1279 actaatgcca cacagaaatt atacaatcaa actagatctg aagcataatt taagaaaaac 1339 atcaacattt tttgtgcttt aaactgtagt agttggtcta gaaacaaaat actccaagaa 1399 aaagaaaatt ttcaaataaa acccaaaata atagctttgc ttagccctgt tagggatcca 1459 ttggagcatt aaggagcaca tatttttatt aacttctttt gagctttcaa tgttgatgta 1519 atttttgttc tctgtgtaat ttaggtaaac tgcagtgttt aacataataa tgttttaaag 1579 acttagttgt cagtattaaa taatcctggc attataggga aaaaacctcc tagaagttag 1639 attatttgct actgtgagaa tattgtcacc actggaagtt actttagttc atttaatttt 1699 aattttatat tttgtgaata ttttaagaac tgtagagctg ctttcaatat ctagaaattt 1759 ttaattgagt gtaaacacac ctaactttaa gaaaaagaac cgcttgtatg attttcaaaa 1819 gaacatttag aattctatag agtcaaaact atagcgtaat gctgtgttta ttaagccagg 1879 gattgtggga cttcccccag gcaactaagc ctgcaggatg aaaatgctat attttctttc 1939 atgcactgtc gatattactc agatttgggg aaatgacatt tttatactaa aacaaacacc 1999 aaaatatttt agaataaatt cttagaaagt tttgagagga atttttagag aggacatttc 2059 ctccttcccg atttggatat tccctcaaat ccctcctctt actccatgct gaaggagaag 2119 tactctcaga tgcattatgt taatggagag aaaaagcaca gtattgtaga gacaccaata 2179 ttagctaatg tattttggag tgttttccat tttacagttt atattccagc actcaaaact 2239 cagggtcaag ttttaacaaa agaggtatgt agtcacagta aatactaaga tggcatttct 2299 atctcagagg gccaaagtga atcacaccag tttctgaagg tcctaaaaat agctcagatg 2359 tcctaatgaa catgcaccta catttaatag gagtacaata aaactgttgt cagcttttgt 2419 tttacagaga acgctagata ttaagaattt tgaaatggat catttctact tgctgtgcat 2479 tttaaccaat aatctgatga atatagaaaa aaatgatcca aaatatggat atgattggat 2539 gtatgtaaca catacatgga gtatggagga aattttctga aaaatacatt tagattagtt 2599 tagtttgaag gagaggtggg ctgatggctg agttgtatgt tactaacttg gccctgactg 2659 gttgtgcaac cattgcttca tttctttgca aaatgtagtt aagatatact ttattctaat 2719 gaaggccttt taaatttgtc cactgcattc ttggtatttc actacttcaa gtcagtcaga 2779 acttcgtaga ccgacctgaa gtttcttttt gaatacttgt ttctttagca ctttgaagat 2839 agaaaaacca ctttttaagt actaagtcat catttgcctt gaaagtttcc tctgcattgg 2899 gtttgaagta gtttagttat gtctttttct ctgtatgtaa gtagtataat ttgttacttt 2959 caaatacccg tactttgaat gtaggttttt ttgttgttgt tatctataaa aattgaggga 3019 aatggttatg caaaaaaata ttttgctttg gaccatattt cttaagcata aaaaaaatgc 3079 tcagttttgc ttgcattcct tgagaatgta tttatctgaa gatcaaaaca aacaatccag 3139 atgtataagt actaggcaga agccaatttt aaaatttcct tgaataatcc atgaaaggaa 3199 taattcaaat acagataaac agagttggca gtatattata gtgataattt tgtattttca 3259 caaaaaaaaa gttaaactct tcttttcttt ttattataat gaccagcttt tggtatttca 3319 ttgttaccaa gttctatttt tagaataaaa ttgttctcct tct 3362 <210> 118 <211> 208 <212> PRT <213> Homo sapiens <400> 118 Met Gly Leu Gly Ala Arg Gly Ala Trp Ala Ala Leu Leu Leu Gly Thr 1 5 10 15 Leu Gln Val Leu Ala Leu Leu Gly Ala Ala His Glu Ser Ala Ala Met 20 25 30 Ala Ala Ser Ala Asn Ile Glu Asn Ser Gly Leu Pro His Asn Ser Ser 35 40 45 Ala Asn Ser Thr Glu Thr Leu Gln His Val Pro Ser Asp His Thr Asn 50 55 60 Glu Thr Ser Asn Ser Thr Val Lys Pro Pro Thr Ser Val Ala Ser Asp 65 70 75 80 Ser Ser Asn Thr Thr Val Thr Thr Met Lys Pro Thr Ala Ala Ser Asn 85 90 95 Thr Thr Thr Pro Gly Met Val Ser Thr Asn Met Thr Ser Thr Thr Leu 100 105 110 Lys Ser Thr Pro Lys Thr Thr Ser Val Ser Gln Asn Thr Ser Gln Ile 115 120 125 Ser Thr Ser Thr Met Thr Val Thr His Asn Ser Ser Val Thr Ser Ala 130 135 140 Ala Ser Ser Val Thr Ile Thr Thr Thr Met His Ser Glu Ala Lys Lys 145 150 155 160 Gly Ser Lys Phe Asp Thr Gly Ser Phe Val Gly Gly Ile Val Leu Thr 165 170 175 Leu Gly Val Leu Ser Ile Leu Tyr Ile Gly Cys Lys Met Tyr Tyr Ser 180 185 190 Arg Arg Gly Ile Arg Tyr Arg Thr Ile Asp Glu His Asp Ala Ile Ile 195 200 205 <210> 119 <211> 3598 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (180)..(1226) <400> 119 aggagacgct gcccttccgc agcgatggca tcccggctct gtggaggggc cctctggtat 60 gtgtgtccct gtccttctgg ggcgtggatg gtgcctggga cccagctggc aaccagttga 120 agacgttctc cttggaagct cttggccctg aggactttgc ctggggcatt ggccctgcc 179 atg gcg ttc cgg agg gcc gag ggc acg tct atg atc cag gcc ctg gcc 227 Met Ala Phe Arg Arg Ala Glu Gly Thr Ser Met Ile Gln Ala Leu Ala 1 5 10 15 atg acg gtg gcc gag atc ccc gtg ttc ctg tac acg acg ttt ggg cag 275 Met Thr Val Ala Glu Ile Pro Val Phe Leu Tyr Thr Thr Phe Gly Gln 20 25 30 tct gca ttc tcc cag cta cgg ttg acg cca ggc ctg cgg aaa gtc ctc 323 Ser Ala Phe Ser Gln Leu Arg Leu Thr Pro Gly Leu Arg Lys Val Leu 35 40 45 ttt gcc acg gcc ctg ggg act gtg gcc ctg gcc ctg gct gcc cac cag 371 Phe Ala Thr Ala Leu Gly Thr Val Ala Leu Ala Leu Ala Ala His Gln 50 55 60 ctg aag agg cga cgg agg agg aag aag cag gtt ggt ccc gag atg gga 419 Leu Lys Arg Arg Arg Arg Arg Lys Lys Gln Val Gly Pro Glu Met Gly 65 70 75 80 ggg gag cag ctg ggc acg gtg ccc ctc cct atc ctc ttg gcc agg aag 467 Gly Glu Gln Leu Gly Thr Val Pro Leu Pro Ile Leu Leu Ala Arg Lys 85 90 95 gtc cct tca gtg aag aaa gga tac tcc agc cgg aga gtc cag agc ccc 515 Val Pro Ser Val Lys Lys Gly Tyr Ser Ser Arg Arg Val Gln Ser Pro 100 105 110 agc agc aag agc aac gac acc ctg agt ggc atc tct tcc att gag ccc 563 Ser Ser Lys Ser Asn Asp Thr Leu Ser Gly Ile Ser Ser Ile Glu Pro 115 120 125 agc aag cac tcg ggc tcc tcc cac agt gtg gcc tcg atg atg gca gtg 611 Ser Lys His Ser Gly Ser Ser His Ser Val Ala Ser Met Met Ala Val 130 135 140 aac tca tcc agc ccc aca gcc gcg tgc tcg gga cta tgg gat gcc aga 659 Asn Ser Ser Ser Pro Thr Ala Ala Cys Ser Gly Leu Trp Asp Ala Arg 145 150 155 160 ggg atg gag gag tct ctg acc acc agc gac ggc aat gca gag agc ctg 707 Gly Met Glu Glu Ser Leu Thr Thr Ser Asp Gly Asn Ala Glu Ser Leu 165 170 175 tac atg caa ggc atg gag ctg ttt gag gaa gct ctg cag aag tgg gag 755 Tyr Met Gln Gly Met Glu Leu Phe Glu Glu Ala Leu Gln Lys Trp Glu 180 185 190 cag gca cta agc gtg ggc cag cgg ggg gac agc ggc agc acc ccc atg 803 Gln Ala Leu Ser Val Gly Gln Arg Gly Asp Ser Gly Ser Thr Pro Met 195 200 205 ccc agg gac ggc ctc cgg aac cca gag act gca tca gag cca ctg tct 851 Pro Arg Asp Gly Leu Arg Asn Pro Glu Thr Ala Ser Glu Pro Leu Ser 210 215 220 gag cca gag tca cag cgg aag gag ttt gca gag aag ctg gag tcc ctg 899 Glu Pro Glu Ser Gln Arg Lys Glu Phe Ala Glu Lys Leu Glu Ser Leu 225 230 235 240 ctg cac cgt gcc tac cac ctg cag gag gag ttc ggc tcc acc ttc ccc 947 Leu His Arg Ala Tyr His Leu Gln Glu Glu Phe Gly Ser Thr Phe Pro 245 250 255 gca gac agc atg ctg cta gac ctc gag agg acc ctc atg ctg ccc ctg 995 Ala Asp Ser Met Leu Leu Asp Leu Glu Arg Thr Leu Met Leu Pro Leu 260 265 270 acc gag ggc tcg ctg cgg ctg cgg gcg gac gat gag gac agc ctg act 1043 Thr Glu Gly Ser Leu Arg Leu Arg Ala Asp Asp Glu Asp Ser Leu Thr 275 280 285 tca gag gat tcc ttc ttc tcc gcc acc gag ctc ttt gag tcc ctg cag 1091 Ser Glu Asp Ser Phe Phe Ser Ala Thr Glu Leu Phe Glu Ser Leu Gln 290 295 300 act gga gat tac ccg atc cca ctc tcc aga ccc gcc gct gcc tat gag 1139 Thr Gly Asp Tyr Pro Ile Pro Leu Ser Arg Pro Ala Ala Ala Tyr Glu 305 310 315 320 gag gcc ctg cag ctg gtg aag gag ggg aga gtg cct tgc cgg acc ctc 1187 Glu Ala Leu Gln Leu Val Lys Glu Gly Arg Val Pro Cys Arg Thr Leu 325 330 335 aga gcc cca aag gct tcc tgg aga gct acg agg aga tgc tgagctatgc 1236 Arg Ala Pro Lys Ala Ser Trp Arg Ala Thr Arg Arg Cys 340 345 cctgcggccc gagacctggg ccacaacacg gctggagctg gagggccgag gggccaaggc 1296 agagggagga atggcctcag ctacacccgt tgcacagcag agcgggaaag acgtgtcccc 1356 cccacgtgtg ctcatgccct ggaccccagc ttcagtctcc ccatctggaa agtggccccg 1416 aggctccggc agtgccccca tgcatgagcc tcccgggggc accctctgta ggtggtatgc 1476 atgagcttct tcgacatcgt gctggacttc atcctcatgg acgccttcga ggacctggag 1536 aaccctccgg cctcggtgct cgccgtcctg cggaaccgct ggctgtcaga cagcttcaag 1596 gagacggcct tggccactgc ttgctggtcg gtcctgaaag ccaagaggag gctgctgatg 1656 gtgcctgatg gcttcatctc ccatttctac tccgtatcgg agcatgtgag ccctgtccta 1716 gccttcggct tccttggacc caagcctcag cttgctgaag tctgtgcttt cttcaagcac 1776 cagattgtgc agtacctgag ggacatgttc gacctggaca atgtgcgcta cacgtcactg 1836 cccgcgctgg cagacgacat cctgcagctg tcccggcgcc gcagcgagat attgctgggg 1896 tacctggggg tgcccgcggc cagcagcgca ggcgtgaatg gggcgctgcc ccgagagaat 1956 gggcccctgg gggagctgca gtagaggcgg cacgggctgg ggggtggcag agagaaggct 2016 cctcctccct tccctgggtt ggtatctgac agctgtggtg gctgagggcc gttgcccctg 2076 actttgcccc acccccatca tctgggagtc cccaaggccc agaggggaca tttccatgga 2136 gaagaacggt tcctggggga agcagaggcc aggaccagtg gggcctgtgg gagagaaagg 2196 ctgtgagaga gggggttgtt gtggagaatt gggacaggca gagccaggat gccccaggtg 2256 ggggacccca aaacctccca tcgctccagg gctgctgaca agggtgctgg gagggtggag 2316 gtgaaggatg gggcctagag ccctgtggtg aaggtcacag tgtcctgagc tagaagccac 2376 ctgtggctat atggtctcag catccagctg gcctgtcctg atgccctccc cacctcaacc 2436 gccttctcag agagtttgca actccagaga aggagagtgg ggccacctta gtgggcagca 2496 ggcctgggcc atccagagat ggggcagagg tgggcctccc actcctgtgc tctcttctga 2556 gcaggaactg ggcccttgac agtgtccttt gacattccct cgccctacca aagatcgtct 2616 tttctcctcc cacctctgtc accaccaaag acgggcggag gtggggctgg gccctcctgc 2676 ccccgcccat cccccttcca tgagcccaga cctccctggg tggtgctagg ctctgagctg 2736 ggggctcaga ccagggatcg ctcaggcccc tgtcacctgt gggcccgggg accacttggg 2796 ggaggtcaga ggatgtatgt ggccggacca gcttccccac cttcattagg acaagaaact 2856 gcccagcact ttgccttcag ttcaacgcac aaacgctcct ggggcctcat gggggcagag 2916 cctcccctgg gcctgcagag agtcctgtta gcagcgacgt ccccccgccg cggggtcctg 2976 tcagcccggc agtgtcttct cagtgtcttc acctgagcga gtgtctgtgg ccccaacgcg 3036 ttctgctgtg gctctgccct ttccaggttg agaggcctgc aggagaaaca cactcccctc 3096 ctgggtttcc acactcagga ggtcagagga ctggctcctg tgaccagggc ccctctcccc 3156 tgaatgggaa aggggtctgg ggatgggagg gcgcaccaca gagaggagat gatgctgggt 3216 gtggcccatc ttctgtgggc cccttcccag acaccggatc catgggcact aacccgcctc 3276 ccaggctgat gcccggaggc agcttcctgg gcaggagggt tccatgggca ctaacccacc 3336 tcccaggctg atgcctggag gcagcctcca gggcaggaag gaccctgtgc tccccgcccc 3396 ccatcctgac atcctgttct tttgcactta ccctgtgctg tgaatgtaac agtgggcctt 3456 ggccccgccc actctgattt gcattttcat ttgtgtttgt ttacacatcc atgcactgcc 3516 tgtagcagtc gattgtcaca gcttcgactt ttggatggta gagtgtgtgc actgactgtg 3576 agtcgaataa acaattgaga cg 3598 <210> 120 <211> 349 <212> PRT <213> Homo sapiens <400> 120 Met Ala Phe Arg Arg Ala Glu Gly Thr Ser Met Ile Gln Ala Leu Ala 1 5 10 15 Met Thr Val Ala Glu Ile Pro Val Phe Leu Tyr Thr Thr Phe Gly Gln 20 25 30 Ser Ala Phe Ser Gln Leu Arg Leu Thr Pro Gly Leu Arg Lys Val Leu 35 40 45 Phe Ala Thr Ala Leu Gly Thr Val Ala Leu Ala Leu Ala Ala His Gln 50 55 60 Leu Lys Arg Arg Arg Arg Arg Lys Lys Gln Val Gly Pro Glu Met Gly 65 70 75 80 Gly Glu Gln Leu Gly Thr Val Pro Leu Pro Ile Leu Leu Ala Arg Lys 85 90 95 Val Pro Ser Val Lys Lys Gly Tyr Ser Ser Arg Arg Val Gln Ser Pro 100 105 110 Ser Ser Lys Ser Asn Asp Thr Leu Ser Gly Ile Ser Ser Ile Glu Pro 115 120 125 Ser Lys His Ser Gly Ser Ser His Ser Val Ala Ser Met Met Ala Val 130 135 140 Asn Ser Ser Ser Pro Thr Ala Ala Cys Ser Gly Leu Trp Asp Ala Arg 145 150 155 160 Gly Met Glu Glu Ser Leu Thr Thr Ser Asp Gly Asn Ala Glu Ser Leu 165 170 175 Tyr Met Gln Gly Met Glu Leu Phe Glu Glu Ala Leu Gln Lys Trp Glu 180 185 190 Gln Ala Leu Ser Val Gly Gln Arg Gly Asp Ser Gly Ser Thr Pro Met 195 200 205 Pro Arg Asp Gly Leu Arg Asn Pro Glu Thr Ala Ser Glu Pro Leu Ser 210 215 220 Glu Pro Glu Ser Gln Arg Lys Glu Phe Ala Glu Lys Leu Glu Ser Leu 225 230 235 240 Leu His Arg Ala Tyr His Leu Gln Glu Glu Phe Gly Ser Thr Phe Pro 245 250 255 Ala Asp Ser Met Leu Leu Asp Leu Glu Arg Thr Leu Met Leu Pro Leu 260 265 270 Thr Glu Gly Ser Leu Arg Leu Arg Ala Asp Asp Glu Asp Ser Leu Thr 275 280 285 Ser Glu Asp Ser Phe Phe Ser Ala Thr Glu Leu Phe Glu Ser Leu Gln 290 295 300 Thr Gly Asp Tyr Pro Ile Pro Leu Ser Arg Pro Ala Ala Ala Tyr Glu 305 310 315 320 Glu Ala Leu Gln Leu Val Lys Glu Gly Arg Val Pro Cys Arg Thr Leu 325 330 335 Arg Ala Pro Lys Ala Ser Trp Arg Ala Thr Arg Arg Cys 340 345 <210> 121 <211> 2451 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (60)..(1328) <400> 121 tcatcacgga cgtggactac ctgcatcaca agtacccagg gacctccatc gtgtttgac 59 atg agc ctc acc tac atc ttg gtg gca ctg gca gct gtc ctc ctg aac 107 Met Ser Leu Thr Tyr Ile Leu Val Ala Leu Ala Ala Val Leu Leu Asn 1 5 10 15 aac gtc ctg gtg gag aga ctg acc ctg cac acc agg atc acc gca ggc 155 Asn Val Leu Val Glu Arg Leu Thr Leu His Thr Arg Ile Thr Ala Gly 20 25 30 tac ctc tta gcc ttg ggc cct ctc ctt ttt atc agc atc tgc gac gtg 203 Tyr Leu Leu Ala Leu Gly Pro Leu Leu Phe Ile Ser Ile Cys Asp Val 35 40 45 tgg ctg cag ctc ttc tct cgg gac cag gcc tac gcc atc aac ctg gcc 251 Trp Leu Gln Leu Phe Ser Arg Asp Gln Ala Tyr Ala Ile Asn Leu Ala 50 55 60 gct gtg ggc acc gtg gcc ttc ggc tgc aca gtg cag caa tcc agc ttc 299 Ala Val Gly Thr Val Ala Phe Gly Cys Thr Val Gln Gln Ser Ser Phe 65 70 75 80 tac ggg tac acg ggg atg ctg ccc aag cgg tac acg cag ggg gtg atg 347 Tyr Gly Tyr Thr Gly Met Leu Pro Lys Arg Tyr Thr Gln Gly Val Met 85 90 95 acc ggg gag agc acg gcg ggc gtg atg atc tct ctg agc cgc atc ctc 395 Thr Gly Glu Ser Thr Ala Gly Val Met Ile Ser Leu Ser Arg Ile Leu 100 105 110 acg aag ctg ctg ctg ccc gac gag cgc gcc agc acg ctc atc ttc ttc 443 Thr Lys Leu Leu Leu Pro Asp Glu Arg Ala Ser Thr Leu Ile Phe Phe 115 120 125 ctg gtg tcg gtg gcg ctg gag ctg ctg tgt ttc ctg ctg cac ctg tta 491 Leu Val Ser Val Ala Leu Glu Leu Leu Cys Phe Leu Leu His Leu Leu 130 135 140 gtg cgg cgc agc cgc ttc gtg ctc ttc cat acc aca cgg ccg cgt gac 539 Val Arg Arg Ser Arg Phe Val Leu Phe His Thr Thr Arg Pro Arg Asp 145 150 155 160 agc cac cgg ggc agg cca ggc ctg ggc agg ggc tat ggc tac cgc gtg 587 Ser His Arg Gly Arg Pro Gly Leu Gly Arg Gly Tyr Gly Tyr Arg Val 165 170 175 cac cac gac gtt gtc gcc ggg gac gtc cac ttc gag cac cca gcc ccg 635 His His Asp Val Val Ala Gly Asp Val His Phe Glu His Pro Ala Pro 180 185 190 gcc ctg gcc ccc aac gag tcc cca aag gac agc cca gcc cac gag gtg 683 Ala Leu Ala Pro Asn Glu Ser Pro Lys Asp Ser Pro Ala His Glu Val 195 200 205 acc ggc agc ggt ggg gcc tac atg cgc ttt gat gtg ccg cgg cca agg 731 Thr Gly Ser Gly Gly Ala Tyr Met Arg Phe Asp Val Pro Arg Pro Arg 210 215 220 gtc cag cgc agc tgg ccc acc ttc aga gcc ctg tta ctg cac cgc tac 779 Val Gln Arg Ser Trp Pro Thr Phe Arg Ala Leu Leu Leu His Arg Tyr 225 230 235 240 gtg gtg gcg cgg gtg atc tgg gcc gac atg ctc tcc atc gcc gtg acc 827 Val Val Ala Arg Val Ile Trp Ala Asp Met Leu Ser Ile Ala Val Thr 245 250 255 tac ttc atc acg ctg tgc ctg ttc ccc ggc ctc gag tct gag atc cgc 875 Tyr Phe Ile Thr Leu Cys Leu Phe Pro Gly Leu Glu Ser Glu Ile Arg 260 265 270 cac tgc atc ctg ggc gag tgg ctg ccc atc ctc atc atg gct gtg ttc 923 His Cys Ile Leu Gly Glu Trp Leu Pro Ile Leu Ile Met Ala Val Phe 275 280 285 aac ctg tca gac ttc gtg ggc aag atc ctg gca gcc ctg ccc gtg gac 971 Asn Leu Ser Asp Phe Val Gly Lys Ile Leu Ala Ala Leu Pro Val Asp 290 295 300 tgg cgg ggc acc cac ctg ctg gcc tgc tcc tgc ctg cgt gtg gtc ttc 1019 Trp Arg Gly Thr His Leu Leu Ala Cys Ser Cys Leu Arg Val Val Phe 305 310 315 320 atc ccc ctc ttc atc ctg tgc gtc tac ccc agc ggc atg ccc gcc ctc 1067 Ile Pro Leu Phe Ile Leu Cys Val Tyr Pro Ser Gly Met Pro Ala Leu 325 330 335 cgt cac ccc gcc tgg ccc tgc atc ttc tca ctg ctc atg ggc atc agc 1115 Arg His Pro Ala Trp Pro Cys Ile Phe Ser Leu Leu Met Gly Ile Ser 340 345 350 aac ggc tac ttc ggc agc gtg ccc atg atc ctg gcg gca ggc aaa gtg 1163 Asn Gly Tyr Phe Gly Ser Val Pro Met Ile Leu Ala Ala Gly Lys Val 355 360 365 agc ccc aag cag cgg gag ctg gca ggg aac acc atg acc gtg tcc tac 1211 Ser Pro Lys Gln Arg Glu Leu Ala Gly Asn Thr Met Thr Val Ser Tyr 370 375 380 atg tca ggg ctg acg ctg ggg tcc gcc gtg gcc tac tgc acc tac agc 1259 Met Ser Gly Leu Thr Leu Gly Ser Ala Val Ala Tyr Cys Thr Tyr Ser 385 390 395 400 ctc acc cgc gac gct cac ggc agc tgc ctg cac gcc tcc acc gcc aat 1307 Leu Thr Arg Asp Ala His Gly Ser Cys Leu His Ala Ser Thr Ala Asn 405 410 415 ggt tcc atc ctc gca ggc ctc tgagccagcc ccgcccactg ccagggacgc 1358 Gly Ser Ile Leu Ala Gly Leu 420 cgagggcctg accaggggcc ccgaggcctg agggcccctc ccctgtcccc acctcagtgc 1418 ctgcggggcc ctgagcctcc ccctgtgcca gcagccccac tcccttaggg tccagccatg 1478 ccccaccctg gactgaagtt ctgcaaagtc ctccgaggac cggaacacgt ttctgcgacc 1538 cggggctctg gccagcactg tgttctgcgt ttggtctcat acctgcgtct accttccatc 1598 tgtgtccagc ggccccggct ccagcccagc cagcactctg cagggtcaca cgcaccgtgt 1658 ccccacccag gacagcagac acccgccaga gtgtgcgcgc ccagtgactg caccccggcc 1718 ctcatcaccc accggcactg atcggggcac cgcctggccc agcctccacc agggacccct 1778 cctcatgaac tctggagccc tgagaggaga ggggcagccc cccaccttgt caccctcagg 1838 gcttcccctt ctgtcctcat tcttagagac tgcttctccc aaacataacg cgttagccat 1898 gaaggagtcg gagccctggg tccgaatgga cccgcctgcg gtctgcatca gcctctggga 1958 aaccacagca gtgatgccag ctgggcacgt caggacctcc ccacacaccc acacgatgcc 2018 acaggtcagg gggctgtgcc tgactaggga gccctcccat tgccttcctg gcccgggata 2078 gaagagggga ggtaagtctg ggggctacga agccgggccc ccacaccctg gctgaagtca 2138 gcttgaccta ggtcttgacc ctcatccagc aagggactcg acagacccaa gggtccctgg 2198 aacgtaggga ggggctgggg gtcactccag cccgggcctc ccagaacacc aggcccgtgt 2258 gggtggcacc ctgaggtcag gggatcctaa gggtgtcctt ccagagacgg tgtttccagg 2318 gggaggaccg cccccgcttc cagatccccg gccccggctg tgactgccct gtttcacccc 2378 tgctgtgtcc catcccccgt ctgtccacta actgtaccgc accggccatt aaaagatgaa 2438 ggcagaccgc tgc 2451 <210> 122 <211> 423 <212> PRT <213> Homo sapiens <400> 122 Met Ser Leu Thr Tyr Ile Leu Val Ala Leu Ala Ala Val Leu Leu Asn 1 5 10 15 Asn Val Leu Val Glu Arg Leu Thr Leu His Thr Arg Ile Thr Ala Gly 20 25 30 Tyr Leu Leu Ala Leu Gly Pro Leu Leu Phe Ile Ser Ile Cys Asp Val 35 40 45 Trp Leu Gln Leu Phe Ser Arg Asp Gln Ala Tyr Ala Ile Asn Leu Ala 50 55 60 Ala Val Gly Thr Val Ala Phe Gly Cys Thr Val Gln Gln Ser Ser Phe 65 70 75 80 Tyr Gly Tyr Thr Gly Met Leu Pro Lys Arg Tyr Thr Gln Gly Val Met 85 90 95 Thr Gly Glu Ser Thr Ala Gly Val Met Ile Ser Leu Ser Arg Ile Leu 100 105 110 Thr Lys Leu Leu Leu Pro Asp Glu Arg Ala Ser Thr Leu Ile Phe Phe 115 120 125 Leu Val Ser Val Ala Leu Glu Leu Leu Cys Phe Leu Leu His Leu Leu 130 135 140 Val Arg Arg Ser Arg Phe Val Leu Phe His Thr Thr Arg Pro Arg Asp 145 150 155 160 Ser His Arg Gly Arg Pro Gly Leu Gly Arg Gly Tyr Gly Tyr Arg Val 165 170 175 His His Asp Val Val Ala Gly Asp Val His Phe Glu His Pro Ala Pro 180 185 190 Ala Leu Ala Pro Asn Glu Ser Pro Lys Asp Ser Pro Ala His Glu Val 195 200 205 Thr Gly Ser Gly Gly Ala Tyr Met Arg Phe Asp Val Pro Arg Pro Arg 210 215 220 Val Gln Arg Ser Trp Pro Thr Phe Arg Ala Leu Leu Leu His Arg Tyr 225 230 235 240 Val Val Ala Arg Val Ile Trp Ala Asp Met Leu Ser Ile Ala Val Thr 245 250 255 Tyr Phe Ile Thr Leu Cys Leu Phe Pro Gly Leu Glu Ser Glu Ile Arg 260 265 270 His Cys Ile Leu Gly Glu Trp Leu Pro Ile Leu Ile Met Ala Val Phe 275 280 285 Asn Leu Ser Asp Phe Val Gly Lys Ile Leu Ala Ala Leu Pro Val Asp 290 295 300 Trp Arg Gly Thr His Leu Leu Ala Cys Ser Cys Leu Arg Val Val Phe 305 310 315 320 Ile Pro Leu Phe Ile Leu Cys Val Tyr Pro Ser Gly Met Pro Ala Leu 325 330 335 Arg His Pro Ala Trp Pro Cys Ile Phe Ser Leu Leu Met Gly Ile Ser 340 345 350 Asn Gly Tyr Phe Gly Ser Val Pro Met Ile Leu Ala Ala Gly Lys Val 355 360 365 Ser Pro Lys Gln Arg Glu Leu Ala Gly Asn Thr Met Thr Val Ser Tyr 370 375 380 Met Ser Gly Leu Thr Leu Gly Ser Ala Val Ala Tyr Cys Thr Tyr Ser 385 390 395 400 Leu Thr Arg Asp Ala His Gly Ser Cys Leu His Ala Ser Thr Ala Asn 405 410 415 Gly Ser Ile Leu Ala Gly Leu 420 <210> 123 <211> 2518 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (29)..(1693) <400> 123 acggtggccg gagcagccgg aagctagc atg gcg gcc gcc ggg gct gcg gct 52 Met Ala Ala Ala Gly Ala Ala Ala 1 5 aca cac cta gag gtg gcc cgg ggc aag cgc gcc gcc ctc ttc ttc gct 100 Thr His Leu Glu Val Ala Arg Gly Lys Arg Ala Ala Leu Phe Phe Ala 10 15 20 gcg gtg gcc atc gtg ctg ggg cta ccg ctc tgg tgg aag acc acg gag 148 Ala Val Ala Ile Val Leu Gly Leu Pro Leu Trp Trp Lys Thr Thr Glu 25 30 35 40 acc tac cgg gcc tcg ttg cct tac tcc cag atc agt ggc ctg aat gcc 196 Thr Tyr Arg Ala Ser Leu Pro Tyr Ser Gln Ile Ser Gly Leu Asn Ala 45 50 55 ctt cag ctc cgc ctc atg gtg cct gtc act gtc gtg ttt acg cgg gag 244 Leu Gln Leu Arg Leu Met Val Pro Val Thr Val Val Phe Thr Arg Glu 60 65 70 tca gtg ccc ctg gac gac cag gag aag ctg ccc ttc acc gtt gtg cat 292 Ser Val Pro Leu Asp Asp Gln Glu Lys Leu Pro Phe Thr Val Val His 75 80 85 gaa aga gag att cct ctg aaa tac aaa atg aaa atc aaa tgc cgt ttc 340 Glu Arg Glu Ile Pro Leu Lys Tyr Lys Met Lys Ile Lys Cys Arg Phe 90 95 100 cag aag gcc tat cgg agg gct ttg gac cat gag gag gag gcc ctg tca 388 Gln Lys Ala Tyr Arg Arg Ala Leu Asp His Glu Glu Glu Ala Leu Ser 105 110 115 120 tcg ggc agt gtg caa gag gca gaa gcc atg tta gat gag cct cag gaa 436 Ser Gly Ser Val Gln Glu Ala Glu Ala Met Leu Asp Glu Pro Gln Glu 125 130 135 caa gcg gag ggc tcc ctg act gtg tac gtg ata tct gaa cac tcc tca 484 Gln Ala Glu Gly Ser Leu Thr Val Tyr Val Ile Ser Glu His Ser Ser 140 145 150 ctt ctt ccc cag gac atg atg agc tac att ggg ccc aag agg aca gca 532 Leu Leu Pro Gln Asp Met Met Ser Tyr Ile Gly Pro Lys Arg Thr Ala 155 160 165 gtg gtg cgg ggg ata atg cac cgg gag gcc ttt aac atc att ggc cgc 580 Val Val Arg Gly Ile Met His Arg Glu Ala Phe Asn Ile Ile Gly Arg 170 175 180 cgc ata gtc cag gtg gcc cag gcc atg tct ttg act gag gat gtg ctt 628 Arg Ile Val Gln Val Ala Gln Ala Met Ser Leu Thr Glu Asp Val Leu 185 190 195 200 gct gct gct ctg gct gac cac ctt cca gag gac aag tgg agc gct gag 676 Ala Ala Ala Leu Ala Asp His Leu Pro Glu Asp Lys Trp Ser Ala Glu 205 210 215 aag agg cgg cct ctc aag tcc agc ttg ggc tat gag atc acc ttc agt 724 Lys Arg Arg Pro Leu Lys Ser Ser Leu Gly Tyr Glu Ile Thr Phe Ser 220 225 230 tta ctc aac cca gac ccc aag tcc cat gat gtc tac tgg gac att gag 772 Leu Leu Asn Pro Asp Pro Lys Ser His Asp Val Tyr Trp Asp Ile Glu 235 240 245 ggg gct gtc cgg cgc tat gtg caa cct tcc ctg aat gcc ctc ggt gcc 820 Gly Ala Val Arg Arg Tyr Val Gln Pro Ser Leu Asn Ala Leu Gly Ala 250 255 260 gct ggc aac ttc tct gtg gac tct cag att ctt tac tat gca atg ttg 868 Ala Gly Asn Phe Ser Val Asp Ser Gln Ile Leu Tyr Tyr Ala Met Leu 265 270 275 280 ggg gtg aat ccc cgc ttt gac tca gct tcc tcc agc tac tat ttg gac 916 Gly Val Asn Pro Arg Phe Asp Ser Ala Ser Ser Ser Tyr Tyr Leu Asp 285 290 295 atg cac agc ctc ccc cat gtc atc aac cca gtg gag tcc cgg ctg gga 964 Met His Ser Leu Pro His Val Ile Asn Pro Val Glu Ser Arg Leu Gly 300 305 310 tcc agt gct gcc tcc ttg tac cct gtg ctc aac ttt cta ctc tac gtg 1012 Ser Ser Ala Ala Ser Leu Tyr Pro Val Leu Asn Phe Leu Leu Tyr Val 315 320 325 cct gag ctt gca cac tca ccg ctg tac att cag gac aag gat ggc gct 1060 Pro Glu Leu Ala His Ser Pro Leu Tyr Ile Gln Asp Lys Asp Gly Ala 330 335 340 cca gtg gcc acc aat gcc ttc cat agt ccc cgc tgg ggt ggc att atg 1108 Pro Val Ala Thr Asn Ala Phe His Ser Pro Arg Trp Gly Gly Ile Met 345 350 355 360 gta tat aat gtt gac tcc aaa acc tat aat gcc tca gtg ctg cca gtg 1156 Val Tyr Asn Val Asp Ser Lys Thr Tyr Asn Ala Ser Val Leu Pro Val 365 370 375 aga gtc gag gtg gac atg gtg cga gtg atg gag gtg ttc ctg gca cag 1204 Arg Val Glu Val Asp Met Val Arg Val Met Glu Val Phe Leu Ala Gln 380 385 390 ttg cgg ttg ctc ttt ggg att gct cag ccc cag ctg cct cca aaa tgc 1252 Leu Arg Leu Leu Phe Gly Ile Ala Gln Pro Gln Leu Pro Pro Lys Cys 395 400 405 ctg ctt tca ggg cct acg agt gaa ggg cta atg acc tgg gag cta gac 1300 Leu Leu Ser Gly Pro Thr Ser Glu Gly Leu Met Thr Trp Glu Leu Asp 410 415 420 cgg ctg ctc tgg gct cgg tca gtg gag aac ctg gcc aca gcc acc acc 1348 Arg Leu Leu Trp Ala Arg Ser Val Glu Asn Leu Ala Thr Ala Thr Thr 425 430 435 440 acc ctt acc tcc ctg gcg cag ctt ctg ggc aag atc agc aac att gtc 1396 Thr Leu Thr Ser Leu Ala Gln Leu Leu Gly Lys Ile Ser Asn Ile Val 445 450 455 att aag gac gac gtg gca tct gag gtg tac aag gct gta gct gcc gtc 1444 Ile Lys Asp Asp Val Ala Ser Glu Val Tyr Lys Ala Val Ala Ala Val 460 465 470 cag aag tcg gca gaa gag ttg gcg tct ggg cac ctg gca tct gcc ttt 1492 Gln Lys Ser Ala Glu Glu Leu Ala Ser Gly His Leu Ala Ser Ala Phe 475 480 485 gtc gcc agc cag gaa gct gtg aca tcc tct gag ctt gcc ttc ttt gac 1540 Val Ala Ser Gln Glu Ala Val Thr Ser Ser Glu Leu Ala Phe Phe Asp 490 495 500 ccg tca ctc ctc cac ctc ctt tat ttc cct gat tac cag aag ttt gcc 1588 Pro Ser Leu Leu His Leu Leu Tyr Phe Pro Asp Tyr Gln Lys Phe Ala 505 510 515 520 atc tac atc cca ctc ttc ctg cct atg gct gtg ccc atc ctc ctg tcc 1636 Ile Tyr Ile Pro Leu Phe Leu Pro Met Ala Val Pro Ile Leu Leu Ser 525 530 535 ctg gtc aag atc ttc ctg gag acc cgc aag tcc tgg aga aag cct gag 1684 Leu Val Lys Ile Phe Leu Glu Thr Arg Lys Ser Trp Arg Lys Pro Glu 540 545 550 aag aca gac tgagcagggc agcacctcca taggaagcct tcctttctgg 1733 Lys Thr Asp 555 ccaaggtggg cggtgttaga ttgtgaggca cgtacatggg gcctgccgga atgacttaaa 1793 tatttgtctc cagtctccac tgttggctct ccagcaacca aagtacaaca ctccaagatg 1853 ggttcatctt ttcttccttt cccattcacc tggctcaatc ctcctccacc accaggggcc 1913 tcaaaaggca catcatccgg gtctccttat cttgtttgat aaggctgctg cctgtctccc 1973 tctgtggcaa ggactgtttg ttcttttgcc ccatttctca acatagcaca cttgtgcact 2033 gagaggaggg agcattatgg gaaagtccct gccttccaca cctctctcta gtccctgtgg 2093 gacagcccta gcccctgctg tcatgaaggg gccaggcatt ggtcacctgt gggaccttct 2153 ccctcactcc cctccctcct agttggcttt gtctgtcagg tgcagtctgg cgggagtcca 2213 ggaggcagca gctcaggaca tggtgctgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 2273 tgtgtcagag gttccagaaa gttccagatt tggaatcaaa cagtcctgaa ttcaaatcct 2333 tgtttttgca cttattgtct ggagagcttt ggataaggta ttgaatctct ctgagcctca 2393 gtttttcatt tgttcaaatg gcactgatga tgtctccctt acaagatggt tgtgaggagt 2453 aaatgtgatc agcatgtaaa gtgtctggcg tgtagtaggc tcttaataaa cactggctga 2513 atatg 2518 <210> 124 <211> 555 <212> PRT <213> Homo sapiens <400> 124 Met Ala Ala Ala Gly Ala Ala Ala Thr His Leu Glu Val Ala Arg Gly 1 5 10 15 Lys Arg Ala Ala Leu Phe Phe Ala Ala Val Ala Ile Val Leu Gly Leu 20 25 30 Pro Leu Trp Trp Lys Thr Thr Glu Thr Tyr Arg Ala Ser Leu Pro Tyr 35 40 45 Ser Gln Ile Ser Gly Leu Asn Ala Leu Gln Leu Arg Leu Met Val Pro 50 55 60 Val Thr Val Val Phe Thr Arg Glu Ser Val Pro Leu Asp Asp Gln Glu 65 70 75 80 Lys Leu Pro Phe Thr Val Val His Glu Arg Glu Ile Pro Leu Lys Tyr 85 90 95 Lys Met Lys Ile Lys Cys Arg Phe Gln Lys Ala Tyr Arg Arg Ala Leu 100 105 110 Asp His Glu Glu Glu Ala Leu Ser Ser Gly Ser Val Gln Glu Ala Glu 115 120 125 Ala Met Leu Asp Glu Pro Gln Glu Gln Ala Glu Gly Ser Leu Thr Val 130 135 140 Tyr Val Ile Ser Glu His Ser Ser Leu Leu Pro Gln Asp Met Met Ser 145 150 155 160 Tyr Ile Gly Pro Lys Arg Thr Ala Val Val Arg Gly Ile Met His Arg 165 170 175 Glu Ala Phe Asn Ile Ile Gly Arg Arg Ile Val Gln Val Ala Gln Ala 180 185 190 Met Ser Leu Thr Glu Asp Val Leu Ala Ala Ala Leu Ala Asp His Leu 195 200 205 Pro Glu Asp Lys Trp Ser Ala Glu Lys Arg Arg Pro Leu Lys Ser Ser 210 215 220 Leu Gly Tyr Glu Ile Thr Phe Ser Leu Leu Asn Pro Asp Pro Lys Ser 225 230 235 240 His Asp Val Tyr Trp Asp Ile Glu Gly Ala Val Arg Arg Tyr Val Gln 245 250 255 Pro Ser Leu Asn Ala Leu Gly Ala Ala Gly Asn Phe Ser Val Asp Ser 260 265 270 Gln Ile Leu Tyr Tyr Ala Met Leu Gly Val Asn Pro Arg Phe Asp Ser 275 280 285 Ala Ser Ser Ser Tyr Tyr Leu Asp Met His Ser Leu Pro His Val Ile 290 295 300 Asn Pro Val Glu Ser Arg Leu Gly Ser Ser Ala Ala Ser Leu Tyr Pro 305 310 315 320 Val Leu Asn Phe Leu Leu Tyr Val Pro Glu Leu Ala His Ser Pro Leu 325 330 335 Tyr Ile Gln Asp Lys Asp Gly Ala Pro Val Ala Thr Asn Ala Phe His 340 345 350 Ser Pro Arg Trp Gly Gly Ile Met Val Tyr Asn Val Asp Ser Lys Thr 355 360 365 Tyr Asn Ala Ser Val Leu Pro Val Arg Val Glu Val Asp Met Val Arg 370 375 380 Val Met Glu Val Phe Leu Ala Gln Leu Arg Leu Leu Phe Gly Ile Ala 385 390 395 400 Gln Pro Gln Leu Pro Pro Lys Cys Leu Leu Ser Gly Pro Thr Ser Glu 405 410 415 Gly Leu Met Thr Trp Glu Leu Asp Arg Leu Leu Trp Ala Arg Ser Val 420 425 430 Glu Asn Leu Ala Thr Ala Thr Thr Thr Leu Thr Ser Leu Ala Gln Leu 435 440 445 Leu Gly Lys Ile Ser Asn Ile Val Ile Lys Asp Asp Val Ala Ser Glu 450 455 460 Val Tyr Lys Ala Val Ala Ala Val Gln Lys Ser Ala Glu Glu Leu Ala 465 470 475 480 Ser Gly His Leu Ala Ser Ala Phe Val Ala Ser Gln Glu Ala Val Thr 485 490 495 Ser Ser Glu Leu Ala Phe Phe Asp Pro Ser Leu Leu His Leu Leu Tyr 500 505 510 Phe Pro Asp Tyr Gln Lys Phe Ala Ile Tyr Ile Pro Leu Phe Leu Pro 515 520 525 Met Ala Val Pro Ile Leu Leu Ser Leu Val Lys Ile Phe Leu Glu Thr 530 535 540 Arg Lys Ser Trp Arg Lys Pro Glu Lys Thr Asp 545 550 555 <210> 125 <211> 2250 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (256)..(1161) <400> 125 aaaaagaaag ggctggcgag tcgaaaggcg aggcggccgc ggcagcgctt gggacgcgcc 60 tgggcaccgg gctcgctccc tgcgccccgg agcaggccaa gttcggggcc aggacgtcgg 120 gaggacctgg tgcatggctg cctcctaatc ccatagtcca gaggaggcat ccctaggact 180 gcgggcaagg gagccgggca agcccagggc agccttgaac cgtcccctgg cctgccctcc 240 ccggtggggg ccagg atg ctg aag aag cag tct gca ggg ctt gtg ctg tgg 291 Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp 1 5 10 ggc gct atc ctc ttt gtg gcc tgg aat gcc ctg ctg ctc ctc ttc ttc 339 Gly Ala Ile Leu Phe Val Ala Trp Asn Ala Leu Leu Leu Leu Phe Phe 15 20 25 tgg acg cgc cca gca cct ggc agg cca ccc tca gtc agc gct ctc gat 387 Trp Thr Arg Pro Ala Pro Gly Arg Pro Pro Ser Val Ser Ala Leu Asp 30 35 40 ggc gac ccc gcc agc ctc acc cag gtc ttc cgg cag ttt cgc ttc ccc 435 Gly Asp Pro Ala Ser Leu Thr Gln Val Phe Arg Gln Phe Arg Phe Pro 45 50 55 60 gcg gcc gtg gtg gtg gag gat gac ctg gag gtg gcc ccg gac ttc ttc 483 Ala Ala Val Val Val Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe 65 70 75 gag tac ttt cag gcc acc tat ccg ctg ctg aag gcc gac ccc tcc ctg 531 Glu Tyr Phe Gln Ala Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu 80 85 90 tgg tgc gtc tcg gcc tgg aat gac aac ggc aag gag cag atg gtg gac 579 Trp Cys Val Ser Ala Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp 95 100 105 gcc agc agg cct gag ctg ctc tac cgc acc gac ttt ttc cct ggc ctg 627 Ala Ser Arg Pro Glu Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu 110 115 120 ggc tgg ctg ctg ttg gcc gag ctc tgg gct gag ctg gag ccc aag tgg 675 Gly Trp Leu Leu Leu Ala Glu Leu Trp Ala Glu Leu Glu Pro Lys Trp 125 130 135 140 cca aag gcc ttc tgg gac gac tgg atg cgg cgg ccg gag cag cgg cag 723 Pro Lys Ala Phe Trp Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Gln 145 150 155 ggg cgg gcc tgc ata cgc cct gag atc tca aga acg atg acc ttt ggc 771 Gly Arg Ala Cys Ile Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly 160 165 170 cgc aag ggt gtg agc cac ggg cag ttc ttt gac cag cac ctc aag ttt 819 Arg Lys Gly Val Ser His Gly Gln Phe Phe Asp Gln His Leu Lys Phe 175 180 185 atc aag ctg aac cag cag ttt gtg cac ttc acc cag ctg gac ctg tct 867 Ile Lys Leu Asn Gln Gln Phe Val His Phe Thr Gln Leu Asp Leu Ser 190 195 200 tac ctg cag cgg gag gcc tat gac cga gat ttc ctc gcc cgc gtc tac 915 Tyr Leu Gln Arg Glu Ala Tyr Asp Arg Asp Phe Leu Ala Arg Val Tyr 205 210 215 220 ggt gct ccc cag ctg cag gtg gag aaa gtg agg acc aat gac cgg aag 963 Gly Ala Pro Gln Leu Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys 225 230 235 gag ttg ggg gag gtt cgg gtg cag tat acg ggc agg gac agc ttc aag 1011 Glu Leu Gly Glu Val Arg Val Gln Tyr Thr Gly Arg Asp Ser Phe Lys 240 245 250 gct ttc gcc aag gct ctg ggt gtc atg gat gac ctt aag tcg ggg gtt 1059 Ala Phe Ala Lys Ala Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val 255 260 265 ccg aga gct ggc tac cgg ggt att gtc acc ttc cag ttc cgg ggc cgc 1107 Pro Arg Ala Gly Tyr Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg 270 275 280 cgt gtc cac ctg gcg ccc cca ccg acg tgg gag ggc tat gat cct agc 1155 Arg Val His Leu Ala Pro Pro Pro Thr Trp Glu Gly Tyr Asp Pro Ser 285 290 295 300 tgg aat tagcacctgc ctgtccttcc tgggcccctc cttgccacat catgagctga 1211 Trp Asn ggtgggacca cagtccccag gctgcatcgg cctgcctgtg tttccctctt aggtgcattt 1271 atctttttga tttttccgag tggcatttaa gtgcacaaat gataacaaga ggattattct 1331 cccgttctca agggagtcag atcaggggaa ctattctagg gtatgttgcg gggtattaag 1391 caggaaacca ctgtgtggtg gggggcactg ggcttgttgg ggccagaaat gtccacgtcc 1451 tgagctttct cctggagcat gtgcagagag tttggcaacg ttcgctctct tgaccagacc 1511 ccttctccct gacctggctc ttccagccag ggcacgagcc ctccttctat acctgctccc 1571 cttcccccag cggggactga gttatgggag aaggggacat atttgtggcc aaaatgatac 1631 taaccaaagg ggcttccttg tcagggcctg gtggagttgg tgggtcatcg gggctcactg 1691 cctcctgccc ttctctcctg tctgaccccc acttagccct tctctccttg cagcctagca 1751 gtttatagtt ctgagatgga aagttgaagg gggcaagcaa gacctctcct cagcccatgc 1811 ccagctgtca ggagagaggt gcagggagga aggccttgtg ctgggacaac ctctctcttg 1871 ccttacctca gagagggact atgccctgac ccctcctttc tgaaaatcag tgccctccct 1931 gttgctctag gaggctcctg ctggcttggt agaagacaga attcgatctg cctgtccctt 1991 tttcccctgg ggtttgacac acaggctcct ctcagcatga ggtggagcag tgaccaggtg 2051 gagcagtgac caggacgcct ctggcccagt gctgcccagc ctccccgccc gctcccaggc 2111 gccccatgtc ctcacaggcc aggacgccat ggcaggatgg agaggacttg gtggattttt 2171 gtttcttgcc tgacctcagt ttcatgaaag aaagtggaag ctacagaatt attttctaaa 2231 ataaaggctg aattgtctg 2250 <210> 126 <211> 302 <212> PRT <213> Homo sapiens <400> 126 Met Leu Lys Lys Gln Ser Ala Gly Leu Val Leu Trp Gly Ala Ile Leu 1 5 10 15 Phe Val Ala Trp Asn Ala Leu Leu Leu Leu Phe Phe Trp Thr Arg Pro 20 25 30 Ala Pro Gly Arg Pro Pro Ser Val Ser Ala Leu Asp Gly Asp Pro Ala 35 40 45 Ser Leu Thr Gln Val Phe Arg Gln Phe Arg Phe Pro Ala Ala Val Val 50 55 60 Val Glu Asp Asp Leu Glu Val Ala Pro Asp Phe Phe Glu Tyr Phe Gln 65 70 75 80 Ala Thr Tyr Pro Leu Leu Lys Ala Asp Pro Ser Leu Trp Cys Val Ser 85 90 95 Ala Trp Asn Asp Asn Gly Lys Glu Gln Met Val Asp Ala Ser Arg Pro 100 105 110 Glu Leu Leu Tyr Arg Thr Asp Phe Phe Pro Gly Leu Gly Trp Leu Leu 115 120 125 Leu Ala Glu Leu Trp Ala Glu Leu Glu Pro Lys Trp Pro Lys Ala Phe 130 135 140 Trp Asp Asp Trp Met Arg Arg Pro Glu Gln Arg Gln Gly Arg Ala Cys 145 150 155 160 Ile Arg Pro Glu Ile Ser Arg Thr Met Thr Phe Gly Arg Lys Gly Val 165 170 175 Ser His Gly Gln Phe Phe Asp Gln His Leu Lys Phe Ile Lys Leu Asn 180 185 190 Gln Gln Phe Val His Phe Thr Gln Leu Asp Leu Ser Tyr Leu Gln Arg 195 200 205 Glu Ala Tyr Asp Arg Asp Phe Leu Ala Arg Val Tyr Gly Ala Pro Gln 210 215 220 Leu Gln Val Glu Lys Val Arg Thr Asn Asp Arg Lys Glu Leu Gly Glu 225 230 235 240 Val Arg Val Gln Tyr Thr Gly Arg Asp Ser Phe Lys Ala Phe Ala Lys 245 250 255 Ala Leu Gly Val Met Asp Asp Leu Lys Ser Gly Val Pro Arg Ala Gly 260 265 270 Tyr Arg Gly Ile Val Thr Phe Gln Phe Arg Gly Arg Arg Val His Leu 275 280 285 Ala Pro Pro Pro Thr Trp Glu Gly Tyr Asp Pro Ser Trp Asn 290 295 300 <210> 127 <211> 1666 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (199)..(1272) <400> 127 ttctctcacc gggactcggg actcccggga agtggaccgg cagaagaggg ggctagctag 60 ctgtctctgc ggaccaggga gacccccgcg cccccccggt gtgaggcggc ctcacagggc 120 cgggtgggct ggcgagccga cgcggcggcg gaggaggctg tgaggagtgt gtggaacagg 180 acccgggaca gaggaacc atg gct ccg cag aac ctg agc acc ttt tgc ctg 231 Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu 1 5 10 ttg ctg cta tac ctc atc ggg gcg gtg att gcc gga cga gat ttc tat 279 Leu Leu Leu Tyr Leu Ile Gly Ala Val Ile Ala Gly Arg Asp Phe Tyr 15 20 25 aag atc ttg ggg gtg cct cga agt gcc tct ata aag gat att aaa aag 327 Lys Ile Leu Gly Val Pro Arg Ser Ala Ser Ile Lys Asp Ile Lys Lys 30 35 40 gcc tat agg aaa cta gcc ctg cag ctt cat ccc gac cgg aac cct gat 375 Ala Tyr Arg Lys Leu Ala Leu Gln Leu His Pro Asp Arg Asn Pro Asp 45 50 55 gat cca caa gcc cag gag aaa ttc cag gat ctg ggt gct gct tat gag 423 Asp Pro Gln Ala Gln Glu Lys Phe Gln Asp Leu Gly Ala Ala Tyr Glu 60 65 70 75 gtt ctg tca gat agt gag aaa cgg aaa cag tac gat act tat ggt gaa 471 Val Leu Ser Asp Ser Glu Lys Arg Lys Gln Tyr Asp Thr Tyr Gly Glu 80 85 90 gaa gga tta aaa gat ggt cat cag agc tcc cat gga gac att ttt tca 519 Glu Gly Leu Lys Asp Gly His Gln Ser Ser His Gly Asp Ile Phe Ser 95 100 105 cac ttc ttt ggg gat ttt ggt ttc atg ttt gga gga acc cct cgt cag 567 His Phe Phe Gly Asp Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gln 110 115 120 caa gac aga aat att cca aga gga agt gat att att gta gat cta gaa 615 Gln Asp Arg Asn Ile Pro Arg Gly Ser Asp Ile Ile Val Asp Leu Glu 125 130 135 gtc act ttg gaa gaa gta tat gca gga aat ttt gtg gaa gta gtt aga 663 Val Thr Leu Glu Glu Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg 140 145 150 155 aac aaa cct gtg gca agg cag gct cct ggc aaa cgg aag tgc aat tgt 711 Asn Lys Pro Val Ala Arg Gln Ala Pro Gly Lys Arg Lys Cys Asn Cys 160 165 170 cgg caa gag atg cgg acc acc cag ctg ggc cct ggg cgc ttc caa atg 759 Arg Gln Glu Met Arg Thr Thr Gln Leu Gly Pro Gly Arg Phe Gln Met 175 180 185 acc cag gag gtg gtc tgc gac gaa tgc cct aat gtc aaa cta gtg aat 807 Thr Gln Glu Val Val Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn 190 195 200 gaa gaa cga acg ctg gaa gta gaa ata gag cct ggg gtg aga gac ggc 855 Glu Glu Arg Thr Leu Glu Val Glu Ile Glu Pro Gly Val Arg Asp Gly 205 210 215 atg gag tac ccc ttt att gga gaa ggt gag cct cac gtg gat ggg gag 903 Met Glu Tyr Pro Phe Ile Gly Glu Gly Glu Pro His Val Asp Gly Glu 220 225 230 235 cct gga gat tta cgg ttc cga atc aaa gtt gtc aag cac cca ata ttt 951 Pro Gly Asp Leu Arg Phe Arg Ile Lys Val Val Lys His Pro Ile Phe 240 245 250 gaa agg aga gga gat gat ttg tac aca aat gtg aca att tca tta gtt 999 Glu Arg Arg Gly Asp Asp Leu Tyr Thr Asn Val Thr Ile Ser Leu Val 255 260 265 gag tca ctg gtt ggc ttt gag atg gat att act cac ttg gat ggt cac 1047 Glu Ser Leu Val Gly Phe Glu Met Asp Ile Thr His Leu Asp Gly His 270 275 280 aag gta cat att tcc cgg gat aag atc acc agg cca gga gcg aag cta 1095 Lys Val His Ile Ser Arg Asp Lys Ile Thr Arg Pro Gly Ala Lys Leu 285 290 295 tgg aag aaa ggg gaa ggg ctc ccc aac ttt gac aac aac aat atc aag 1143 Trp Lys Lys Gly Glu Gly Leu Pro Asn Phe Asp Asn Asn Asn Ile Lys 300 305 310 315 ggc tct ttg ata atc act ttt gat gtg gat ttt cca aaa gaa cag tta 1191 Gly Ser Leu Ile Ile Thr Phe Asp Val Asp Phe Pro Lys Glu Gln Leu 320 325 330 aca gag gaa gcg aga gaa ggt atc aaa cag cta ctg aaa caa ggg tca 1239 Thr Glu Glu Ala Arg Glu Gly Ile Lys Gln Leu Leu Lys Gln Gly Ser 335 340 345 gtg cag aag gta tac aat gga ctg caa gga tat tgagagtgaa taaaattgga 1292 Val Gln Lys Val Tyr Asn Gly Leu Gln Gly Tyr 350 355 ctttgtttaa aataagtgaa taagcgatat ttattatctg caaggttttt ttgtgtgtgt 1352 ttttgttttt attttcaata tgcaagttag gcttaatttt tttatctaat gatcatcatg 1412 aaatgaataa gagggcttaa gaatttgtcc atttgcattc ggaaaagaat gaccagcaaa 1472 aggtttacta atacctctcc ctttggggat ttaatgtctg gtgctgccgc ctgagtttca 1532 agaattaaag ctgcaagagg actccaggag caaaagaaac acaatataga gggttggagt 1592 tgttagcaat ttcattcaaa atgccaactg gagaagtctg tttttaaata cattttgttg 1652 ttattttttt catg 1666 <210> 128 <211> 358 <212> PRT <213> Homo sapiens <400> 128 Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu 1 5 10 15 Ile Gly Ala Val Ile Ala Gly Arg Asp Phe Tyr Lys Ile Leu Gly Val 20 25 30 Pro Arg Ser Ala Ser Ile Lys Asp Ile Lys Lys Ala Tyr Arg Lys Leu 35 40 45 Ala Leu Gln Leu His Pro Asp Arg Asn Pro Asp Asp Pro Gln Ala Gln 50 55 60 Glu Lys Phe Gln Asp Leu Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser 65 70 75 80 Glu Lys Arg Lys Gln Tyr Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp 85 90 95 Gly His Gln Ser Ser His Gly Asp Ile Phe Ser His Phe Phe Gly Asp 100 105 110 Phe Gly Phe Met Phe Gly Gly Thr Pro Arg Gln Gln Asp Arg Asn Ile 115 120 125 Pro Arg Gly Ser Asp Ile Ile Val Asp Leu Glu Val Thr Leu Glu Glu 130 135 140 Val Tyr Ala Gly Asn Phe Val Glu Val Val Arg Asn Lys Pro Val Ala 145 150 155 160 Arg Gln Ala Pro Gly Lys Arg Lys Cys Asn Cys Arg Gln Glu Met Arg 165 170 175 Thr Thr Gln Leu Gly Pro Gly Arg Phe Gln Met Thr Gln Glu Val Val 180 185 190 Cys Asp Glu Cys Pro Asn Val Lys Leu Val Asn Glu Glu Arg Thr Leu 195 200 205 Glu Val Glu Ile Glu Pro Gly Val Arg Asp Gly Met Glu Tyr Pro Phe 210 215 220 Ile Gly Glu Gly Glu Pro His Val Asp Gly Glu Pro Gly Asp Leu Arg 225 230 235 240 Phe Arg Ile Lys Val Val Lys His Pro Ile Phe Glu Arg Arg Gly Asp 245 250 255 Asp Leu Tyr Thr Asn Val Thr Ile Ser Leu Val Glu Ser Leu Val Gly 260 265 270 Phe Glu Met Asp Ile Thr His Leu Asp Gly His Lys Val His Ile Ser 275 280 285 Arg Asp Lys Ile Thr Arg Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu 290 295 300 Gly Leu Pro Asn Phe Asp Asn Asn Asn Ile Lys Gly Ser Leu Ile Ile 305 310 315 320 Thr Phe Asp Val Asp Phe Pro Lys Glu Gln Leu Thr Glu Glu Ala Arg 325 330 335 Glu Gly Ile Lys Gln Leu Leu Lys Gln Gly Ser Val Gln Lys Val Tyr 340 345 350 Asn Gly Leu Gln Gly Tyr 355 <210> 129 <211> 1686 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (121)..(1548) <400> 129 ggtgactggg tggggctgcc tcacttctgc ctgatttggg aagcgctgca aggacaaccg 60 gctggggtcc ttgcgcgccg cggctcaggg aggagcaccg actgcgccgc accctgagag 120 atg gtt ggt gcc atg tgg aag gtg att gtt tcg ctg gtc ctg ttg atg 168 Met Val Gly Ala Met Trp Lys Val Ile Val Ser Leu Val Leu Leu Met 1 5 10 15 cct ggc ccc tgt gat ggg ctg ttt cgc tcc cta tac aga agt gtt tcc 216 Pro Gly Pro Cys Asp Gly Leu Phe Arg Ser Leu Tyr Arg Ser Val Ser 20 25 30 atg cca cct aag gga gac tca gga cag cca tta ttt ctc acc cct tac 264 Met Pro Pro Lys Gly Asp Ser Gly Gln Pro Leu Phe Leu Thr Pro Tyr 35 40 45 att gaa gct ggg aag atc caa aaa gga aga gaa ttg agt ttg gtc ggc 312 Ile Glu Ala Gly Lys Ile Gln Lys Gly Arg Glu Leu Ser Leu Val Gly 50 55 60 cct ttc cca gga ctg aac atg aag agt tat gcc ggc ttc ctc acc gtg 360 Pro Phe Pro Gly Leu Asn Met Lys Ser Tyr Ala Gly Phe Leu Thr Val 65 70 75 80 aat aag act tac aac agc aac ctc ttc ttc tgg ttc ttc cca gct cag 408 Asn Lys Thr Tyr Asn Ser Asn Leu Phe Phe Trp Phe Phe Pro Ala Gln 85 90 95 ata cag cca gaa gat gcc cca gta gtt ctc tgg cta cag ggt ggg ccg 456 Ile Gln Pro Glu Asp Ala Pro Val Val Leu Trp Leu Gln Gly Gly Pro 100 105 110 gga ggt tca tcc atg ttt gga ctc ttt gtg gaa cat ggg cct tat gtt 504 Gly Gly Ser Ser Met Phe Gly Leu Phe Val Glu His Gly Pro Tyr Val 115 120 125 gtc aca agt aac atg acc ttg cgt gac aga gac ttc ccc tgg acc aca 552 Val Thr Ser Asn Met Thr Leu Arg Asp Arg Asp Phe Pro Trp Thr Thr 130 135 140 acg ctc tcc atg ctt tac att gac aat cca gtg ggc aca ggc ttc agt 600 Thr Leu Ser Met Leu Tyr Ile Asp Asn Pro Val Gly Thr Gly Phe Ser 145 150 155 160 ttt act gat gat acc cac gga tat gca gtc aat gag gac gat gta gca 648 Phe Thr Asp Asp Thr His Gly Tyr Ala Val Asn Glu Asp Asp Val Ala 165 170 175 cgg gat tta tac agt gca cta att cag ttt ttc cag ata ttt cct gaa 696 Arg Asp Leu Tyr Ser Ala Leu Ile Gln Phe Phe Gln Ile Phe Pro Glu 180 185 190 tat aaa aat aat gac ttt tat gtc act ggg gag tct tat gca ggg aaa 744 Tyr Lys Asn Asn Asp Phe Tyr Val Thr Gly Glu Ser Tyr Ala Gly Lys 195 200 205 tat gtg cca gcc att gca cac ctc atc cat tcc ctc aac cct gtg aga 792 Tyr Val Pro Ala Ile Ala His Leu Ile His Ser Leu Asn Pro Val Arg 210 215 220 gag gtg aag atc aac ctg aac gga att gct att gga gat gga tat tct 840 Glu Val Lys Ile Asn Leu Asn Gly Ile Ala Ile Gly Asp Gly Tyr Ser 225 230 235 240 gat ccc gaa tca att ata ggg ggc tat gca gaa ttc ctg tac caa att 888 Asp Pro Glu Ser Ile Ile Gly Gly Tyr Ala Glu Phe Leu Tyr Gln Ile 245 250 255 ggc ttg ttg gat gag aag caa aaa aag tac ttc cag aag cag tgc cat 936 Gly Leu Leu Asp Glu Lys Gln Lys Lys Tyr Phe Gln Lys Gln Cys His 260 265 270 gaa tgc ata gaa cac atc agg aag cag aac tgg ttt gag gcc ctt gaa 984 Glu Cys Ile Glu His Ile Arg Lys Gln Asn Trp Phe Glu Ala Leu Glu 275 280 285 ata ctg gat aaa cta cta gat ggc gac tta aca agt gat cct tct tac 1032 Ile Leu Asp Lys Leu Leu Asp Gly Asp Leu Thr Ser Asp Pro Ser Tyr 290 295 300 ttc cag aat gtt aca gga tgt agt aat tac tat aac ttt ttg cgg tgc 1080 Phe Gln Asn Val Thr Gly Cys Ser Asn Tyr Tyr Asn Phe Leu Arg Cys 305 310 315 320 acg gaa cct gag gat cag ctt tac tat gtg aaa ttt ttg tca ctc cca 1128 Thr Glu Pro Glu Asp Gln Leu Tyr Tyr Val Lys Phe Leu Ser Leu Pro 325 330 335 gag gtg aga caa gcc atc cac gtg ggg aat cag act ttt aat gat gga 1176 Glu Val Arg Gln Ala Ile His Val Gly Asn Gln Thr Phe Asn Asp Gly 340 345 350 act ata gtt gaa aag tac ttg cga gaa gat aca gta cag tca gtt aag 1224 Thr Ile Val Glu Lys Tyr Leu Arg Glu Asp Thr Val Gln Ser Val Lys 355 360 365 cca tgg tta act gaa atc atg aat aat tat aag gtt ctg atc tac aat 1272 Pro Trp Leu Thr Glu Ile Met Asn Asn Tyr Lys Val Leu Ile Tyr Asn 370 375 380 ggc caa ctg gac atc atc gtg gca gct gcc ctg aca gag cgc tcc ttg 1320 Gly Gln Leu Asp Ile Ile Val Ala Ala Ala Leu Thr Glu Arg Ser Leu 385 390 395 400 atg ggc atg gac tgg aaa gga tcc cag gaa tac aag aag gca gaa aaa 1368 Met Gly Met Asp Trp Lys Gly Ser Gln Glu Tyr Lys Lys Ala Glu Lys 405 410 415 aaa gtt tgg aag atc ttt aaa tct gac agt gaa gtg gct ggt tac atc 1416 Lys Val Trp Lys Ile Phe Lys Ser Asp Ser Glu Val Ala Gly Tyr Ile 420 425 430 cgg caa gtg ggt gac ttc cat cag gta att att cga ggt gga gga cat 1464 Arg Gln Val Gly Asp Phe His Gln Val Ile Ile Arg Gly Gly Gly His 435 440 445 att tta ccc tat gac cag cct ctg aga gct ttt gac atg att aat cga 1512 Ile Leu Pro Tyr Asp Gln Pro Leu Arg Ala Phe Asp Met Ile Asn Arg 450 455 460 ttc att tat gga aaa gga tgg gat cct tat gtt gga taaactacct 1558 Phe Ile Tyr Gly Lys Gly Trp Asp Pro Tyr Val Gly 465 470 475 tcctaaaaga gaacatcaga ggttttcatt gctgaaaaga aaatcgtaaa aacagaaaat 1618 gtcataggaa taaaaaaatt atcttttcat atctgcaaga tttttttcat caataaaaat 1678 tatccttg 1686 <210> 130 <211> 476 <212> PRT <213> Homo sapiens <400> 130 Met Val Gly Ala Met Trp Lys Val Ile Val Ser Leu Val Leu Leu Met 1 5 10 15 Pro Gly Pro Cys Asp Gly Leu Phe Arg Ser Leu Tyr Arg Ser Val Ser 20 25 30 Met Pro Pro Lys Gly Asp Ser Gly Gln Pro Leu Phe Leu Thr Pro Tyr 35 40 45 Ile Glu Ala Gly Lys Ile Gln Lys Gly Arg Glu Leu Ser Leu Val Gly 50 55 60 Pro Phe Pro Gly Leu Asn Met Lys Ser Tyr Ala Gly Phe Leu Thr Val 65 70 75 80 Asn Lys Thr Tyr Asn Ser Asn Leu Phe Phe Trp Phe Phe Pro Ala Gln 85 90 95 Ile Gln Pro Glu Asp Ala Pro Val Val Leu Trp Leu Gln Gly Gly Pro 100 105 110 Gly Gly Ser Ser Met Phe Gly Leu Phe Val Glu His Gly Pro Tyr Val 115 120 125 Val Thr Ser Asn Met Thr Leu Arg Asp Arg Asp Phe Pro Trp Thr Thr 130 135 140 Thr Leu Ser Met Leu Tyr Ile Asp Asn Pro Val Gly Thr Gly Phe Ser 145 150 155 160 Phe Thr Asp Asp Thr His Gly Tyr Ala Val Asn Glu Asp Asp Val Ala 165 170 175 Arg Asp Leu Tyr Ser Ala Leu Ile Gln Phe Phe Gln Ile Phe Pro Glu 180 185 190 Tyr Lys Asn Asn Asp Phe Tyr Val Thr Gly Glu Ser Tyr Ala Gly Lys 195 200 205 Tyr Val Pro Ala Ile Ala His Leu Ile His Ser Leu Asn Pro Val Arg 210 215 220 Glu Val Lys Ile Asn Leu Asn Gly Ile Ala Ile Gly Asp Gly Tyr Ser 225 230 235 240 Asp Pro Glu Ser Ile Ile Gly Gly Tyr Ala Glu Phe Leu Tyr Gln Ile 245 250 255 Gly Leu Leu Asp Glu Lys Gln Lys Lys Tyr Phe Gln Lys Gln Cys His 260 265 270 Glu Cys Ile Glu His Ile Arg Lys Gln Asn Trp Phe Glu Ala Leu Glu 275 280 285 Ile Leu Asp Lys Leu Leu Asp Gly Asp Leu Thr Ser Asp Pro Ser Tyr 290 295 300 Phe Gln Asn Val Thr Gly Cys Ser Asn Tyr Tyr Asn Phe Leu Arg Cys 305 310 315 320 Thr Glu Pro Glu Asp Gln Leu Tyr Tyr Val Lys Phe Leu Ser Leu Pro 325 330 335 Glu Val Arg Gln Ala Ile His Val Gly Asn Gln Thr Phe Asn Asp Gly 340 345 350 Thr Ile Val Glu Lys Tyr Leu Arg Glu Asp Thr Val Gln Ser Val Lys 355 360 365 Pro Trp Leu Thr Glu Ile Met Asn Asn Tyr Lys Val Leu Ile Tyr Asn 370 375 380 Gly Gln Leu Asp Ile Ile Val Ala Ala Ala Leu Thr Glu Arg Ser Leu 385 390 395 400 Met Gly Met Asp Trp Lys Gly Ser Gln Glu Tyr Lys Lys Ala Glu Lys 405 410 415 Lys Val Trp Lys Ile Phe Lys Ser Asp Ser Glu Val Ala Gly Tyr Ile 420 425 430 Arg Gln Val Gly Asp Phe His Gln Val Ile Ile Arg Gly Gly Gly His 435 440 445 Ile Leu Pro Tyr Asp Gln Pro Leu Arg Ala Phe Asp Met Ile Asn Arg 450 455 460 Phe Ile Tyr Gly Lys Gly Trp Asp Pro Tyr Val Gly 465 470 475 <210> 131 <211> 1999 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (121)..(888) <400> 131 aaaactcttt cttcggctcg cgagctgaga ggagcaggta gaggggcaga ggcgggactg 60 tcgtctgggg gagccgccca ggaggctcct caggccgacc ccagaccctg gctggccagg 120 atg aag tat ctc cgg cac cgg cgg ccc aat gcc acc ctc att ctg gcc 168 Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 1 5 10 15 atc ggc gct ttc acc ctc ctc ctc ttc agt ctg cta gtg tca cca ccc 216 Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 20 25 30 acc tgc aag gtc cag gag cag cca ccg gcg atc ccc gag gcc ctg gcc 264 Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 35 40 45 tgg ccc act cca ccc acc cgc cca gcc ccg gcc ccg tgc cat gcc aac 312 Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 50 55 60 acc tct atg gtc acc cac ccg gac ttc gcc acg cag ccg cag cac gtt 360 Thr Ser Met Val Thr His Pro Asp Phe Ala Thr Gln Pro Gln His Val 65 70 75 80 cag aac ttc ctc ctg tac aga cac tgc cgc cac ctc ttc gtg ggg caa 408 Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Leu Phe Val Gly Gln 85 90 95 ctg atc caa aac gtg ggc ccc atc cgg gct ttt tgg agc aag tac tat 456 Leu Ile Gln Asn Val Gly Pro Ile Arg Ala Phe Trp Ser Lys Tyr Tyr 100 105 110 gtg cca gag gtg gtg act cag aat gag cgg tac cca ccc tat tgt ggg 504 Val Pro Glu Val Val Thr Gln Asn Glu Arg Tyr Pro Pro Tyr Cys Gly 115 120 125 ggt ggt ggc ttc ttg ctg tcc cgc ttc acg gcc gct gcc ctg cgc cgt 552 Gly Gly Gly Phe Leu Leu Ser Arg Phe Thr Ala Ala Ala Leu Arg Arg 130 135 140 gct gcc cat gtc ttg gac atc ttc ccc att gat gat gtc ttc ctg ggt 600 Ala Ala His Val Leu Asp Ile Phe Pro Ile Asp Asp Val Phe Leu Gly 145 150 155 160 atg tgt ctg gag ctt gag gga ctg aag cct gcc tcc cac agc ggc atc 648 Met Cys Leu Glu Leu Glu Gly Leu Lys Pro Ala Ser His Ser Gly Ile 165 170 175 cgc acg tct ggc gtg cgg gct cca tcg caa cgc ctg tcc tcc ttt gac 696 Arg Thr Ser Gly Val Arg Ala Pro Ser Gln Arg Leu Ser Ser Phe Asp 180 185 190 ccc tgc ttc tac cga gac ctg ctg ctg gtg cac cgc ttc cta cct tat 744 Pro Cys Phe Tyr Arg Asp Leu Leu Leu Val His Arg Phe Leu Pro Tyr 195 200 205 gag atg ctg ctc atg tgg gat gcg ctg aac cag ccc aac ctc acc tgc 792 Glu Met Leu Leu Met Trp Asp Ala Leu Asn Gln Pro Asn Leu Thr Cys 210 215 220 ggc aat cag aca cag atc tac cga gtc agc atc agg gtc ccc agc ctc 840 Gly Asn Gln Thr Gln Ile Tyr Arg Val Ser Ile Arg Val Pro Ser Leu 225 230 235 240 tgg gct cct gtt tcc ata gga agg ggc gac acc ttc ctc cca gga agc 888 Trp Ala Pro Val Ser Ile Gly Arg Gly Asp Thr Phe Leu Pro Gly Ser 245 250 255 tgagaccttt gtggtctgag cataagggag tgccagggaa ggtttgaggt ttgatgagtg 948 aatattctgg ctggcgaact cctacacatc cttcaaaacc cacctggtac tgttccagca 1008 tcttccctgg atggctggag gaactccaga aaatatccat cttctttttg tggctgctaa 1068 tggcagaagt gcctgtgcta gagttccaac tgtggatgca tccgtcccgt ttgagtcaaa 1128 gtcttacttc cctgctctca cctactcaca gacgggatgc taagcagtgc acctgcagtg 1188 gtttaatggc agataagctc cgtctgcagt tccaggccag ccagaaactc ctgtgtccac 1248 atagagctga cgtgagaaat atctttcagc ccaggagaga ggggtcctga tcttaaccct 1308 ttcctgggtc tcagacaact cagaaggttg gggggatacc agagaggtgg tggaatagga 1368 ccgccccctc cttacttgtg ggatcaaatg ctgtaatggt ggaggtgtgg gcagaggagg 1428 gaggcaagtg tcctttgaaa gttgtgagag ctcagagttt ctggggtcct cattaggagc 1488 ccccatccct gtgttcccca agaattcaga gaacagcact ggggctggaa tgatctttaa 1548 tgggcccaag gccaacaggc atatgcctca ctactgcctg gagaagggag agattcaggt 1608 cctccagcag cctccctcac ccagtatgtt ttacagatta cggggggacc gggtgagcca 1668 gtgacccctt gtagccccca gcttcaggcc tcagtgtctg ccagtcaagc ttcacaggca 1728 ttgtgatggg gcagccttgg ggaatataaa attttgtgaa gacttggaga tctttttttt 1788 tttttaagca aatttacaag tttcaacaga caagtccaca ttcatcccta aaagtctcat 1848 tttccagtag aaaatataca ctggtaaaaa cggggcatgg ggccgtggct cagggctgta 1908 attctagcac attgggagac caaagtggga ggatcacttg agcccaggag ttctggatcc 1968 tgcctctgca caaaataaaa aattactcag g 1999 <210> 132 <211> 256 <212> PRT <213> Homo sapiens <400> 132 Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 1 5 10 15 Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 20 25 30 Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 35 40 45 Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 50 55 60 Thr Ser Met Val Thr His Pro Asp Phe Ala Thr Gln Pro Gln His Val 65 70 75 80 Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Leu Phe Val Gly Gln 85 90 95 Leu Ile Gln Asn Val Gly Pro Ile Arg Ala Phe Trp Ser Lys Tyr Tyr 100 105 110 Val Pro Glu Val Val Thr Gln Asn Glu Arg Tyr Pro Pro Tyr Cys Gly 115 120 125 Gly Gly Gly Phe Leu Leu Ser Arg Phe Thr Ala Ala Ala Leu Arg Arg 130 135 140 Ala Ala His Val Leu Asp Ile Phe Pro Ile Asp Asp Val Phe Leu Gly 145 150 155 160 Met Cys Leu Glu Leu Glu Gly Leu Lys Pro Ala Ser His Ser Gly Ile 165 170 175 Arg Thr Ser Gly Val Arg Ala Pro Ser Gln Arg Leu Ser Ser Phe Asp 180 185 190 Pro Cys Phe Tyr Arg Asp Leu Leu Leu Val His Arg Phe Leu Pro Tyr 195 200 205 Glu Met Leu Leu Met Trp Asp Ala Leu Asn Gln Pro Asn Leu Thr Cys 210 215 220 Gly Asn Gln Thr Gln Ile Tyr Arg Val Ser Ile Arg Val Pro Ser Leu 225 230 235 240 Trp Ala Pro Val Ser Ile Gly Arg Gly Asp Thr Phe Leu Pro Gly Ser 245 250 255 <210> 133 <211> 1906 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (48)..(353) <400> 133 agaagaggag aagaggttgt gtgggacaag ctgctcccga cagaagg atg tcg ctg 56 Met Ser Leu 1 ctg agc ctg ccc tgg ctg ggc ctc aga ccg gtg gca atg tcc cca tgg 104 Leu Ser Leu Pro Trp Leu Gly Leu Arg Pro Val Ala Met Ser Pro Trp 5 10 15 cta ctc ctg ctg ctg gtt gtg ggc tcc tgg cta ctc gcc cgc atc ctg 152 Leu Leu Leu Leu Leu Val Val Gly Ser Trp Leu Leu Ala Arg Ile Leu 20 25 30 35 gct tgg acc tat gcc ttc tat aac aac tgc cgc cgg ctc cag tgt ttc 200 Ala Trp Thr Tyr Ala Phe Tyr Asn Asn Cys Arg Arg Leu Gln Cys Phe 40 45 50 cca cag ccc cca aaa cgg aac tgg ttt tgg ggt cac ctg ggc ctg atc 248 Pro Gln Pro Pro Lys Arg Asn Trp Phe Trp Gly His Leu Gly Leu Ile 55 60 65 act cct aca gag gag ggc ttg aag gac tcg acc cag atg tcg gcc acc 296 Thr Pro Thr Glu Glu Gly Leu Lys Asp Ser Thr Gln Met Ser Ala Thr 70 75 80 tat tcc cag ggc ttt acg ctg cca ttg cac cca agg ata atc tct tca 344 Tyr Ser Gln Gly Phe Thr Leu Pro Leu His Pro Arg Ile Ile Ser Ser 85 90 95 tca ggt tcc tgaagccctg gctgggtgag tacctgcagg tgaaaggggt 393 Ser Gly Ser 100 tggggacaac cttgcgggga gggtagggga agtgctgctc ttgcccattg tccttggctg 453 ccctactagg agaagggata ctgctgagtg gcggtgacaa gtggagccgc caccgtcgga 513 tgctgacgcc cgccttccat ttcaacatcc tgaagtccta tataacgatc ttcaacaaga 573 gtgcaaacat catgcttgac aagtggcagc acctggcctc agagggcagc agtcgtctgg 633 acatgtttga gcacatcagc ctcatgacct tggacagtct acagaaatgc atcttcagct 693 ttgacagcca ttgtcaggag aggcccagtg aatatattgc caccatcttg gagctcagtg 753 cccttgtaga gaaaagaagc cagcatatcc tccagcacat ggactttctg tattacctct 813 cccatgacgg gcggcgcttc cacagggcct gccgcctggt gcatgacttc acagacgctg 873 tcatccggga gcggcgtcgc accctcccca ctcagggtat tgatgatttt ttcaaagaca 933 aagccaagtc caagactttg gatttcattg atgtgcttct gctgagcaag gatgaagatg 993 ggaaggcatt gtcagatgag gatataagag cagaggctga caccttcatg tttggaggcc 1053 atgacaccac ggccagtggg ctctcctggg tcctgtacaa ccttgcgagg cacccagaat 1113 accaggagcg ctgccgacag gaggtgcaag agcttctgaa ggaccgcgat cctaaagaga 1173 ttgaatggga cgacctggcc cagctgccct tcctgaccat gtgcgtgaag gagagcctga 1233 ggttacatcc cccagctccc ttcatctccc gatgctgcac ccaggacatt gttctcccag 1293 atggccgagt catccccaaa ggcattacct gcctcatcga tattataggg gtccatcaca 1353 acccaactgt gtggccggat cctgaggtgc tgccttcccc attcaccacc accaccccca 1413 tcctctactt ttgtgtgtgt gtgtgtgaat tccaaggttc ctagtggagg gggcagggtt 1473 ttgatgagga aaatccaaca tcacctcacc ccaaaacaca cacaagtgtc tctccaaggc 1533 tgctggacat aggaaatccc actggcaaac cttctttgtc tcacctgcag gtctacgacc 1593 ccttccgctt tgacccagag aacagcaagg ggaggtcacc tctggctttt attcctttct 1653 ccgcagggcc caggaactgc atcgggcagg cgttcgccat ggcggagatg aaagtggtcc 1713 tggcgttgat gctgctgcac ttccggttcc tgccagacca cactgagccc cgcgggaagc 1773 tggaattgat catgcgcgcc gagggcgggc tttggctgcg ggtggagccc ctgaatgtag 1833 gcttgcagtg actttctgac ccatccacct gtttttttgc agattgtcat gaataaaacg 1893 gtgctgtcac ctc 1906 <210> 134 <211> 102 <212> PRT <213> Homo sapiens <400> 134 Met Ser Leu Leu Ser Leu Pro Trp Leu Gly Leu Arg Pro Val Ala Met 1 5 10 15 Ser Pro Trp Leu Leu Leu Leu Leu Val Val Gly Ser Trp Leu Leu Ala 20 25 30 Arg Ile Leu Ala Trp Thr Tyr Ala Phe Tyr Asn Asn Cys Arg Arg Leu 35 40 45 Gln Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Trp Gly His Leu 50 55 60 Gly Leu Ile Thr Pro Thr Glu Glu Gly Leu Lys Asp Ser Thr Gln Met 65 70 75 80 Ser Ala Thr Tyr Ser Gln Gly Phe Thr Leu Pro Leu His Pro Arg Ile 85 90 95 Ile Ser Ser Ser Gly Ser 100 <210> 135 <211> 1773 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(654) <400> 135 atg gcg ccc ctc aga aca act gta ttg ctg tgg agc ctc ttg agg agt 48 Met Ala Pro Leu Arg Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 1 5 10 15 tct ccg ggc gtg gaa cgg gtc tgt ttc cgg gct cga atc cag ccc tgg 96 Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 20 25 30 cac ggt ggc ctg ctc caa ccg cta cct tgc tct ttc gag atg ggg ctg 144 His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 35 40 45 cca cgc cgc cgg ttc agc tcc gag gcc gca gaa tct ggt agc cca gag 192 Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 50 55 60 acc aag aaa cct aca ttt atg gat gag gaa gtt caa agc ata ctc acg 240 Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 65 70 75 80 aaa atg aca ggc ttg aac ttg cag aag act ttt aag cca gct ata caa 288 Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 85 90 95 gaa ctg aag cca cca acc tat aag cta atg act cag gca cag ttg gaa 336 Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 100 105 110 gag gct aca aga cag gca gtt gag gca gct aaa gta cga tta aaa atg 384 Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 115 120 125 cca cca gtt ctg gaa gag cga gta cca ata aat gat gtg tta gct gaa 432 Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 130 135 140 gat aag att ttg gaa gga aca gaa aca acc aaa tat gtg ttt act gat 480 Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 145 150 155 160 ata tca tat agc ata cca cac cgg gag cgt ttt att gtc gtc aga gaa 528 Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 165 170 175 cca agt ggc aca cta cgc aaa gcc tct tgg gaa gaa cgg gac cga atg 576 Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 180 185 190 ata caa gtt tat ttc cca aaa gaa ggt cgt aaa att ttg aca cca ata 624 Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 195 200 205 att ttc aag gaa gaa aat ctt agg gta agg tgacttaggt tttatgtttt 674 Ile Phe Lys Glu Glu Asn Leu Arg Val Arg 210 215 agagccagtg gtgatgattt atttgtagaa ccagttggct ttgtgccttg atccagataa 734 acatttctaa tgataacttg actttttttt ttttttgaaa tggagtttcg ctccttttgc 794 ccaggctgaa gtgcagtggc gggatctcag ctcactgcaa cctccacctt ctggtttcaa 854 gtgattcttc tgcctcagcc tcatgagtag ctgggattac aggcgcccgc caccacgctt 914 ggctaatttt tgtattttta gtagagatgg ggtttcacca tgttggccag gctggtcttg 974 aactcctgac ctcgggattc gcaccacccc ccccaatccg actcccaaag tgctgggatt 1034 acaggcgtga gccaccacgc ctggccgact tctttcttaa tagaatcctc cttaccaccc 1094 aagatgggtt gtactagggt tctctcataa ttggcttagc tggaatttga atctaggtgt 1154 gacaattaca aagcctgtgt tctttcttta tgcttcttga ggagcacaga gtggccagta 1214 tgtgggtggg caggcctgtc atgacatcag gacaggtgct gaacttcagt gttctcatgt 1274 gatgctaact ctgctgtgtg gttttagact atgtatagcc aggacaggca tgttgatgtc 1334 ctcaatctct gctttgccca gtttgagcca gattccacag agtatatcaa ggttcatcac 1394 aagacctatg aagatataga taaacgtggg aaatatgacc ttttacgttc aacaagatac 1454 tttggtggaa tggtgtggta ttttgtaaat aataaaaaga ttgatggttt gctgattgac 1514 cagattcaga gagatttaat cgatgatgca accaacttgg tccagctgta tcacgtgctc 1574 catccagatg gccagtcggc tcaaggggcc aaggatcagg ctgctgaggg aataaattta 1634 atcaaggtct ttgcaaaaac agaagcacag aagggagcct atatagaact aacactgcag 1694 acttatcaag aagcactcag tcgccattct gcagcttcct aaaaatattt taaaaataca 1754 tttattttac taaatactg 1773 <210> 136 <211> 218 <212> PRT <213> Homo sapiens <400> 136 Met Ala Pro Leu Arg Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 1 5 10 15 Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 20 25 30 His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 35 40 45 Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 50 55 60 Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 65 70 75 80 Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 85 90 95 Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 100 105 110 Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 115 120 125 Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 130 135 140 Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 145 150 155 160 Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 165 170 175 Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 180 185 190 Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 195 200 205 Ile Phe Lys Glu Glu Asn Leu Arg Val Arg 210 215 <210> 137 <211> 2134 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (74)..(991) <400> 137 atcagacctg agcagttgct ccggcggcgc tcggggaggg agccagcagc ctagggccta 60 ggcccgggcc acc atg gcg ctg cct cca ggc cca gcc gcc ctc cgg cac 109 Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His 1 5 10 aca ctg ctg ctc ctg cca gcc ctt ctg agc tca ggt tgg ggg gag ttg 157 Thr Leu Leu Leu Leu Pro Ala Leu Leu Ser Ser Gly Trp Gly Glu Leu 15 20 25 gag cca caa ata gat ggt cag acc tgg gct gag cgg gca ctt cgg gag 205 Glu Pro Gln Ile Asp Gly Gln Thr Trp Ala Glu Arg Ala Leu Arg Glu 30 35 40 aat gaa cgc cac gcc ttc acc tgc cgg gtg gca ggg ggg cct ggc acc 253 Asn Glu Arg His Ala Phe Thr Cys Arg Val Ala Gly Gly Pro Gly Thr 45 50 55 60 ccc aga ttg gcc tgg tat ctg gat gga cag ctg cag gag gcc agc acc 301 Pro Arg Leu Ala Trp Tyr Leu Asp Gly Gln Leu Gln Glu Ala Ser Thr 65 70 75 tca aga ctg ctg agc gtg gga ggg gag gcc ttc tct gga ggc acc agc 349 Ser Arg Leu Leu Ser Val Gly Gly Glu Ala Phe Ser Gly Gly Thr Ser 80 85 90 acc ttc act gtc act gcc cat cgg gcc cag cat gag ctc aac tgc tct 397 Thr Phe Thr Val Thr Ala His Arg Ala Gln His Glu Leu Asn Cys Ser 95 100 105 ctg cag gac ccc aga agt ggc cga tca gcc aac gcc tct gtc atc ctt 445 Leu Gln Asp Pro Arg Ser Gly Arg Ser Ala Asn Ala Ser Val Ile Leu 110 115 120 aat gtg caa ttc aag cca gag att gcc caa gtc ggc gcc aag tac cag 493 Asn Val Gln Phe Lys Pro Glu Ile Ala Gln Val Gly Ala Lys Tyr Gln 125 130 135 140 gaa gct cag ggc cca ggc ctc ctg gtt gtc ctg ttt gcc ctg gtg cgt 541 Glu Ala Gln Gly Pro Gly Leu Leu Val Val Leu Phe Ala Leu Val Arg 145 150 155 gcc aac ccg ccg gcc aat gtc acc tgg atc gac cag gat ggg cca gtg 589 Ala Asn Pro Pro Ala Asn Val Thr Trp Ile Asp Gln Asp Gly Pro Val 160 165 170 act gtc aac acc tct gac ttc ctg gtg ctg gat gcg cag aac tac ccc 637 Thr Val Asn Thr Ser Asp Phe Leu Val Leu Asp Ala Gln Asn Tyr Pro 175 180 185 tgg ctc acc aac cac acg gtg cag ctg cag ctc cgc agc ctg gca cac 685 Trp Leu Thr Asn His Thr Val Gln Leu Gln Leu Arg Ser Leu Ala His 190 195 200 aac ctc tcg gtg gtg gcc acc aat gac gtg ggt gtc acc agt gcg tcg 733 Asn Leu Ser Val Val Ala Thr Asn Asp Val Gly Val Thr Ser Ala Ser 205 210 215 220 ctt cca gcc cca ggc ccc tcc cgg cac cca tct ctg gta tca agt gac 781 Leu Pro Ala Pro Gly Pro Ser Arg His Pro Ser Leu Val Ser Ser Asp 225 230 235 tcc aac aac cta aaa ctc aac aac gtg cgc ctg cca cgg gag aac atg 829 Ser Asn Asn Leu Lys Leu Asn Asn Val Arg Leu Pro Arg Glu Asn Met 240 245 250 tcc ctc ccg tcc aac ctt cag ctc aat gac ctc act cca gat tcc agg 877 Ser Leu Pro Ser Asn Leu Gln Leu Asn Asp Leu Thr Pro Asp Ser Arg 255 260 265 gtg aaa cca gca gac cgg cag atg gct cag aac aac agc cgg cca gag 925 Val Lys Pro Ala Asp Arg Gln Met Ala Gln Asn Asn Ser Arg Pro Glu 270 275 280 ctt ctg gac ccg gag ccc ggc ggc ctc ctc acc agc cga gga aga aga 973 Leu Leu Asp Pro Glu Pro Gly Gly Leu Leu Thr Ser Arg Gly Arg Arg 285 290 295 300 aat cag gac aaa gac gca taacagaggg aagaccatgg gaagacacag 1021 Asn Gln Asp Lys Asp Ala 305 aagatggcca agaagagacc cctcagaaga aatcaatctt ggtggggcgt ggtggcttca 1081 cgcctgtaat accagcactg tgggaggttg aggtgggcag atcgcctgag cctaggagtt 1141 cgagaccagc ctgggcaaca tggtgaaatt ccatctctac aaaaaaatta gccgggtgtg 1201 gtgttgagta tctgtagtcc cagctacttg ggaggctggg gtgggaggac tgcttgagtc 1261 cagcaggttg aggctgcagt gagctgagat tgagctactg cactccagcc tgggcataga 1321 gtaataccct gtaaaaaaaa aggaaggaag ggagggaggg aatcaaccat gccaacaaat 1381 tgatcttgga ctactactgg actactagcc tccagaacta tgaaataata catttctgat 1441 gtctaagcca ctcagtctat ggtactttgt tatggcagcc tagcaaaata atacaacatg 1501 ctattttttc ccccgatcag tatggaattg gtcatatgtt ttataggtaa aatacactgc 1561 catactcttt tcctgtggga atctgtgaaa aagaaactga taccaagtta tgggcaagta 1621 ttaacagtta tatatgcatt acttggtgtt ataatgccta atgattccag gacaccatat 1681 gaacagagaa aatgggcatg acatctaact caggtaacag gctctggatc taaacaagtc 1741 acagtgtgaa gtttttaaac tactggtttc ttaaaacttc ttttctcttt ttacaaaaaa 1801 cagagtacat atagttctgc aacttgctgc aatttgcttt tttcatttaa caacatatca 1861 ctgatatttc ttcatattag agcaaaataa ggccaaataa tattccattg catagtattt 1921 cactgaatgg atgtactgca acctagctat tcaatcccct aatcagacac cttcccctca 1981 actacagctt caaaatgctc tgaggaaaga gactgtttcc aaattctgtg tgtttacaat 2041 caattcttca tatacaaaaa aaatctgtct ttgtagagct tacattttag tagggaagaa 2101 caaaataagt aaataaagtc tatggtatgc tag 2134 <210> 138 <211> 306 <212> PRT <213> Homo sapiens <400> 138 Met Ala Leu Pro Pro Gly Pro Ala Ala Leu Arg His Thr Leu Leu Leu 1 5 10 15 Leu Pro Ala Leu Leu Ser Ser Gly Trp Gly Glu Leu Glu Pro Gln Ile 20 25 30 Asp Gly Gln Thr Trp Ala Glu Arg Ala Leu Arg Glu Asn Glu Arg His 35 40 45 Ala Phe Thr Cys Arg Val Ala Gly Gly Pro Gly Thr Pro Arg Leu Ala 50 55 60 Trp Tyr Leu Asp Gly Gln Leu Gln Glu Ala Ser Thr Ser Arg Leu Leu 65 70 75 80 Ser Val Gly Gly Glu Ala Phe Ser Gly Gly Thr Ser Thr Phe Thr Val 85 90 95 Thr Ala His Arg Ala Gln His Glu Leu Asn Cys Ser Leu Gln Asp Pro 100 105 110 Arg Ser Gly Arg Ser Ala Asn Ala Ser Val Ile Leu Asn Val Gln Phe 115 120 125 Lys Pro Glu Ile Ala Gln Val Gly Ala Lys Tyr Gln Glu Ala Gln Gly 130 135 140 Pro Gly Leu Leu Val Val Leu Phe Ala Leu Val Arg Ala Asn Pro Pro 145 150 155 160 Ala Asn Val Thr Trp Ile Asp Gln Asp Gly Pro Val Thr Val Asn Thr 165 170 175 Ser Asp Phe Leu Val Leu Asp Ala Gln Asn Tyr Pro Trp Leu Thr Asn 180 185 190 His Thr Val Gln Leu Gln Leu Arg Ser Leu Ala His Asn Leu Ser Val 195 200 205 Val Ala Thr Asn Asp Val Gly Val Thr Ser Ala Ser Leu Pro Ala Pro 210 215 220 Gly Pro Ser Arg His Pro Ser Leu Val Ser Ser Asp Ser Asn Asn Leu 225 230 235 240 Lys Leu Asn Asn Val Arg Leu Pro Arg Glu Asn Met Ser Leu Pro Ser 245 250 255 Asn Leu Gln Leu Asn Asp Leu Thr Pro Asp Ser Arg Val Lys Pro Ala 260 265 270 Asp Arg Gln Met Ala Gln Asn Asn Ser Arg Pro Glu Leu Leu Asp Pro 275 280 285 Glu Pro Gly Gly Leu Leu Thr Ser Arg Gly Arg Arg Asn Gln Asp Lys 290 295 300 Asp Ala 305 <210> 139 <211> 1828 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (83)..(487) <400> 139 aagcgacgac ttccgccctc cttagggccg tggtcccgta gctaccggtc gcgtcgccgt 60 gggcgacgtg cccgcttcca aa atg gcg gcg gcg gcg gta tct ggt gcg ctt 112 Met Ala Ala Ala Ala Val Ser Gly Ala Leu 1 5 10 ggc cgg gcg ggc tgg agg ctc ctg cag ctg cga tgc ctg ccc gtg gcc 160 Gly Arg Ala Gly Trp Arg Leu Leu Gln Leu Arg Cys Leu Pro Val Ala 15 20 25 cgt tgc cga caa gcc ctg gtg ccg cgt gcc ttc cat gct tca gct gtg 208 Arg Cys Arg Gln Ala Leu Val Pro Arg Ala Phe His Ala Ser Ala Val 30 35 40 ggg cta agg tct tca gat gag cag aag cag cag cct ccc aac tca ttt 256 Gly Leu Arg Ser Ser Asp Glu Gln Lys Gln Gln Pro Pro Asn Ser Phe 45 50 55 tct cag cag cat tct gag aca cag ggc gca gaa aaa cct gat cca gag 304 Ser Gln Gln His Ser Glu Thr Gln Gly Ala Glu Lys Pro Asp Pro Glu 60 65 70 tct tct cat tca ccc ccc agg tat aca gac cag ggc ggc gag gag gag 352 Ser Ser His Ser Pro Pro Arg Tyr Thr Asp Gln Gly Gly Glu Glu Glu 75 80 85 90 gag gac tat gaa agt gag gag cag ttg cag cac cgc atc ctg acg gca 400 Glu Asp Tyr Glu Ser Glu Glu Gln Leu Gln His Arg Ile Leu Thr Ala 95 100 105 gcc ctt gag ttt gtg ccc gcc cac ggg tgg aca gca gag gcg att gca 448 Ala Leu Glu Phe Val Pro Ala His Gly Trp Thr Ala Glu Ala Ile Ala 110 115 120 gaa gga gcc cag gtg tgt ata ggt gag ggt ggg gcc acc taaccaagat 497 Glu Gly Ala Gln Val Cys Ile Gly Glu Gly Gly Ala Thr 125 130 135 gagccaggat ggagtcacac caggcagagc ggggggcctc atgccttctt ccagtctagc 557 tcagagcccc tcacagctgc aagattgact ggtttttttc ccccaatagg gtggaactgg 617 ctttattttg tagttataaa gaacatacca tggagttggt tcttgggagt tgtgttctaa 677 aggcaatcta ttaggcaaga attgtctgtg atcaaaactc ccatgtttca ttgactctaa 737 gatgccattg gttgtaagaa gcatcatttt taaatgcatc agtaaaaaag aaaacatact 797 gcccttcgaa ctatgacaaa gcacttctgt gattcacact gattttttaa aatgaaaaat 857 atatctgcat cttagaatta atgacatatg gtgtttgaaa acccccaaga aggcaccact 917 ttggagacca acacatctta ttttcccaga aactctaata gcattttctg cattagtaca 977 gactgctgct ttagattagg cagcaggctc atgttcaggc catgttgtag agaatcctcc 1037 agcatagcaa gataccatcc tccaagagac tgaggggatg acagagttgc atcttccatc 1097 ccaggcttgc tgcagggcat ctacccatgg acaatgggca aggttgctgc tttactgaaa 1157 tttaactgtt atttccttgt cttctctcac tcccaagtgc acatttggta acagaagtct 1217 cattagtgaa atgtgggtgc tctgactcca ctgtaggctc attgtgaaaa ctgaacaata 1277 caaacaaata taaaaaagaa tgtagaaaac acctataatc acaccaaaga tcatactatc 1337 aacatttatg cctagatctt tccaattaaa accctttata tgattcattc tttaaatgtt 1397 tattgagcaa ataatgtgcc ctaggcactg tgctagtcca agagacatga caggggtcaa 1457 agtggtcaag atggatctgc ttcctgccct tgttgagctt ccagtctagc aacattaata 1517 aaatatatac aaatgtttac ttagaagatg tggtaagtgc tatcaaggaa aggtgctgtt 1577 gggctgtata atggagggac ccgatcatta gatcaggtca cagctgcgag attgactggt 1637 ttctttccct caatagggtg gaaatggctt tattttgtgg atataaaagt aatgaaccat 1697 ggaattggtt cttgagagtt gtgttctaaa ggcaacctat tggcaagaat tgtctgtgat 1757 caaaactacc atatttcatt gactctaaga tgccattggt tgtaagaagc actattttta 1817 agtacatcag t 1828 <210> 140 <211> 135 <212> PRT <213> Homo sapiens <400> 140 Met Ala Ala Ala Ala Val Ser Gly Ala Leu Gly Arg Ala Gly Trp Arg 1 5 10 15 Leu Leu Gln Leu Arg Cys Leu Pro Val Ala Arg Cys Arg Gln Ala Leu 20 25 30 Val Pro Arg Ala Phe His Ala Ser Ala Val Gly Leu Arg Ser Ser Asp 35 40 45 Glu Gln Lys Gln Gln Pro Pro Asn Ser Phe Ser Gln Gln His Ser Glu 50 55 60 Thr Gln Gly Ala Glu Lys Pro Asp Pro Glu Ser Ser His Ser Pro Pro 65 70 75 80 Arg Tyr Thr Asp Gln Gly Gly Glu Glu Glu Glu Asp Tyr Glu Ser Glu 85 90 95 Glu Gln Leu Gln His Arg Ile Leu Thr Ala Ala Leu Glu Phe Val Pro 100 105 110 Ala His Gly Trp Thr Ala Glu Ala Ile Ala Glu Gly Ala Gln Val Cys 115 120 125 Ile Gly Glu Gly Gly Ala Thr 130 135 <210> 141 <211> 2934 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (10)..(804) <400> 141 agttgagag atg gcg gcc gcc gca ggt aga tcg ctc ctg ctg ctc ctc tcc 51 Met Ala Ala Ala Ala Gly Arg Ser Leu Leu Leu Leu Leu Ser 1 5 10 tct cgg ggc ggc ggc ggc ggg ggc gcc ggc ggc tgc ggg gcg ctg act 99 Ser Arg Gly Gly Gly Gly Gly Gly Ala Gly Gly Cys Gly Ala Leu Thr 15 20 25 30 gcc ggc tgc ttc cct ggg ctg ggc gtc agc cgc cac cgg cag cag cag 147 Ala Gly Cys Phe Pro Gly Leu Gly Val Ser Arg His Arg Gln Gln Gln 35 40 45 cac cac cgg acg gta cac cag agg atc gct tcc tgg cag aat ttg gga 195 His His Arg Thr Val His Gln Arg Ile Ala Ser Trp Gln Asn Leu Gly 50 55 60 gct gtt tat tgc agc act gtt gtg ccc tct gat gat gtt aca gtg gtt 243 Ala Val Tyr Cys Ser Thr Val Val Pro Ser Asp Asp Val Thr Val Val 65 70 75 tat caa aat ggg tta cct gtg ata tct gtg agg cta cca tcc cgg cgt 291 Tyr Gln Asn Gly Leu Pro Val Ile Ser Val Arg Leu Pro Ser Arg Arg 80 85 90 gaa cgc tgt cag ttc aca ctc aag cct atc tct gac tct gtt ggt gta 339 Glu Arg Cys Gln Phe Thr Leu Lys Pro Ile Ser Asp Ser Val Gly Val 95 100 105 110 ttt tta cga caa ctg caa gaa gag gat cgg gga att gac aga gtt gct 387 Phe Leu Arg Gln Leu Gln Glu Glu Asp Arg Gly Ile Asp Arg Val Ala 115 120 125 atc tat tca cca gat ggt gtt cgc gtt gct gct tca aca gga ata gac 435 Ile Tyr Ser Pro Asp Gly Val Arg Val Ala Ala Ser Thr Gly Ile Asp 130 135 140 ctc ctc ctc ctt gat gac ttt aag ctg gtc att aat gac tta aca tac 483 Leu Leu Leu Leu Asp Asp Phe Lys Leu Val Ile Asn Asp Leu Thr Tyr 145 150 155 cac gta cga cca cca aaa aga gac ctc tta agt cat gaa aat gca gca 531 His Val Arg Pro Pro Lys Arg Asp Leu Leu Ser His Glu Asn Ala Ala 160 165 170 acg ctg aat gat gta aag aca ttg gtc cag cag cta tac acc aca ctg 579 Thr Leu Asn Asp Val Lys Thr Leu Val Gln Gln Leu Tyr Thr Thr Leu 175 180 185 190 tgc att gag cag cac cag tta aac aag gaa agg gag ctt att gaa aga 627 Cys Ile Glu Gln His Gln Leu Asn Lys Glu Arg Glu Leu Ile Glu Arg 195 200 205 cta gag gat ctc aaa gag cag ctg gct ccc ctg gaa aag gta cga att 675 Leu Glu Asp Leu Lys Glu Gln Leu Ala Pro Leu Glu Lys Val Arg Ile 210 215 220 gag att agc aga aaa gct gag aag agg acc act ttg gtg cta tgg gtg 723 Glu Ile Ser Arg Lys Ala Glu Lys Arg Thr Thr Leu Val Leu Trp Val 225 230 235 gcc ttg cct aca tgg cca cac agt ttg gca ttt tgg ccc ggc tta cct 771 Ala Leu Pro Thr Trp Pro His Ser Leu Ala Phe Trp Pro Gly Leu Pro 240 245 250 ggt ggg aat att cct ggg aca tca tgg agc cag taacatactt catcacttat 824 Gly Gly Asn Ile Pro Gly Thr Ser Trp Ser Gln 255 260 265 ggaagtgcca tggcaatgta tgcatatttt gtaatgacac gccaggaata tgtttatcca 884 gaagccagag acagacaata cttactattt ttccataaag gagccaaaaa gtcacgtttt 944 gacctagaga aatacaatca actcaaggat gcaattgctc aggcagaaat ggaccttaag 1004 agactgagag acccattaca agtacatctg cctctccgac aaattggtga aaaagattga 1064 tctgcaaaaa gcctctgaat cctggcagaa ggaacacctg tttgcctttt taattaaagc 1124 attgcaggtg gaagctggga gccatgtggg gggtagagcg tttttacctt taattataaa 1184 acaaaaacag aaaggatctg agggaagaag ggaatgttaa aacctgagga tcaggcattg 1244 tggaatataa gctcaaaggg cttagtgaat attgtcttaa ccaagtatct cagtttctgg 1304 atgaaaatga tgcagttata tagttgagag attcataaag agaaaacaat gctgggggtg 1364 ttcgtttctt gcatcttctt tgcagagtca gcaaaagagt aacacaccag caccccactc 1424 gactctattt gtttttaatt taactgtccc tatttttgac ataggagtaa ataaatatac 1484 tagaaaagca aattctcatg atatgctaaa atatcattag catttatttt aaattggacc 1544 cagtctctgc agagttacca ggaatctttc cttccagcat ccctttactg accacctacc 1604 tgtacctctt ggttacactc attttttcca tttgataatt ggaaccaact tataactgtt 1664 taataattga cactttagat tatctcttaa taccttctta aatgtctata tatcccagtg 1724 ctctggatca gtgtctaaaa atcactggca acactgcatg aggttgttgg ttttgttttg 1784 ttttattaat tagtctttca caggaggaat aattgccctc ctttatatac ttatctattg 1844 ataatcccct ctccctccag aacacaaatc agagggaaag ggggtgttca gctgtactac 1904 caaatcagga agatgtaagg tttacaaatt ggctaagaat catggctctg tagccatctc 1964 aaccagaata attttattgc taatctgctt tgtgtgacag cattccaggc cagccagatg 2024 ggactgcctt gtctggaggc tttgttcatc tcgaaggaca cacacttcca cactgtttgt 2084 gagccctccc acctccacaa cttcagttgt aaatcaagtg tgtggatctc aaagggtgca 2144 atttatcttt atataggaat acatttctag ggcttccttc aagcccactc tcttcaccct 2204 attttttctt atcttaaatt gagagaaaga gaattaatct tatactttgt caaaacattt 2264 tctaccatat ttccagatga catctgcgct tgaagagtca aaggaatctg tgtctaatat 2324 cctgttttta actgctgtag gggcaggatg gaaaggatga tgggggctgc cacaccactg 2384 attggccttt tctttcacgt gattcatcct tcctcattgt ggcaaggagt ttctttctct 2444 ttttcttcct cctttgggat cattgtgtat gaaaagaaaa actttaaatg acaaacccag 2504 actccaggtg ccttgcaaag gttgaaggcc agccaggatt gctgctgctg ctgctactcc 2564 tgccaacacc cctttcattg gcatgacgga atgaaaggat gcatgtctcc acttcctgac 2624 cctccgccca cttccttctc cctccaccac ccccagtcgt cagctccttc cctcatttat 2684 ttttgttaag ttgtgtgaat tatttttaac ccatttatcc tgtttgtgca tagggttttt 2744 aagaagaaac agcacagtgc aacgagcaaa tctttttggg gtgtgtggga agcaagggag 2804 ggaggacatg gagaaaagtt ctttaaacaa atagcaaact attgaacatg tgtaaaatcc 2864 tgtatcattt atgaaatatg tataaaaagc aatgtacctt ctggaacaat aaatacttat 2924 tcaatttttg 2934 <210> 142 <211> 265 <212> PRT <213> Homo sapiens <400> 142 Met Ala Ala Ala Ala Gly Arg Ser Leu Leu Leu Leu Leu Ser Ser Arg 1 5 10 15 Gly Gly Gly Gly Gly Gly Ala Gly Gly Cys Gly Ala Leu Thr Ala Gly 20 25 30 Cys Phe Pro Gly Leu Gly Val Ser Arg His Arg Gln Gln Gln His His 35 40 45 Arg Thr Val His Gln Arg Ile Ala Ser Trp Gln Asn Leu Gly Ala Val 50 55 60 Tyr Cys Ser Thr Val Val Pro Ser Asp Asp Val Thr Val Val Tyr Gln 65 70 75 80 Asn Gly Leu Pro Val Ile Ser Val Arg Leu Pro Ser Arg Arg Glu Arg 85 90 95 Cys Gln Phe Thr Leu Lys Pro Ile Ser Asp Ser Val Gly Val Phe Leu 100 105 110 Arg Gln Leu Gln Glu Glu Asp Arg Gly Ile Asp Arg Val Ala Ile Tyr 115 120 125 Ser Pro Asp Gly Val Arg Val Ala Ala Ser Thr Gly Ile Asp Leu Leu 130 135 140 Leu Leu Asp Asp Phe Lys Leu Val Ile Asn Asp Leu Thr Tyr His Val 145 150 155 160 Arg Pro Pro Lys Arg Asp Leu Leu Ser His Glu Asn Ala Ala Thr Leu 165 170 175 Asn Asp Val Lys Thr Leu Val Gln Gln Leu Tyr Thr Thr Leu Cys Ile 180 185 190 Glu Gln His Gln Leu Asn Lys Glu Arg Glu Leu Ile Glu Arg Leu Glu 195 200 205 Asp Leu Lys Glu Gln Leu Ala Pro Leu Glu Lys Val Arg Ile Glu Ile 210 215 220 Ser Arg Lys Ala Glu Lys Arg Thr Thr Leu Val Leu Trp Val Ala Leu 225 230 235 240 Pro Thr Trp Pro His Ser Leu Ala Phe Trp Pro Gly Leu Pro Gly Gly 245 250 255 Asn Ile Pro Gly Thr Ser Trp Ser Gln 260 265 <210> 143 <211> 1658 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (57)..(947) <400> 143 attgtgtctg gcggcggcgc gcgagcccac cggcggctgc ggcggggcgg gaagcc atg 59 Met 1 gag ccg cgg gcg ctc gtc acg gcg ctc agc ctc ggc ctc agc ctg tgc 107 Glu Pro Arg Ala Leu Val Thr Ala Leu Ser Leu Gly Leu Ser Leu Cys 5 10 15 tcc ctg ggg ctg ctc gtc acg gcc atc ttc acc gac cac tgg tac gag 155 Ser Leu Gly Leu Leu Val Thr Ala Ile Phe Thr Asp His Trp Tyr Glu 20 25 30 acc gac ccc cgg cgc cac aag gag agc tgc gag cgc agc cgc gcg ggc 203 Thr Asp Pro Arg Arg His Lys Glu Ser Cys Glu Arg Ser Arg Ala Gly 35 40 45 gcc gac ccc ccg gac cag aag aac cgc ctg atg ccg ctg tcg cac ctg 251 Ala Asp Pro Pro Asp Gln Lys Asn Arg Leu Met Pro Leu Ser His Leu 50 55 60 65 ccg ctg cgg gac tcg ccc ccg ctg ggg cgc cgg ctg ctc ccg ggc ggc 299 Pro Leu Arg Asp Ser Pro Pro Leu Gly Arg Arg Leu Leu Pro Gly Gly 70 75 80 ccg ggg cgc gcc gac ccc gag tcc tgg cgc tcg ctc ctg ggg ctc ggc 347 Pro Gly Arg Ala Asp Pro Glu Ser Trp Arg Ser Leu Leu Gly Leu Gly 85 90 95 ggg ctg gac gcc gag tgc ggc cgg ccc ctc ttc gcc acc tac tcg ggc 395 Gly Leu Asp Ala Glu Cys Gly Arg Pro Leu Phe Ala Thr Tyr Ser Gly 100 105 110 ctc tgg agg aag tgc tac ttc ctg ggc atc gac cgg gac atc gac acc 443 Leu Trp Arg Lys Cys Tyr Phe Leu Gly Ile Asp Arg Asp Ile Asp Thr 115 120 125 ctc atc ctg aaa ggt att gcg cag cga tgc acg gcc atc aag tac cac 491 Leu Ile Leu Lys Gly Ile Ala Gln Arg Cys Thr Ala Ile Lys Tyr His 130 135 140 145 ttt tct cag ccc atc cgc ttg cga aac att cct ttt aat tta acc aag 539 Phe Ser Gln Pro Ile Arg Leu Arg Asn Ile Pro Phe Asn Leu Thr Lys 150 155 160 acc ata cag caa gat gag tgg cac ctg ctt cat tta aga aga atc act 587 Thr Ile Gln Gln Asp Glu Trp His Leu Leu His Leu Arg Arg Ile Thr 165 170 175 gct ggc ttc ctc ggc atg gcc gta gcc gtc ctt ctc tgc ggc tgc att 635 Ala Gly Phe Leu Gly Met Ala Val Ala Val Leu Leu Cys Gly Cys Ile 180 185 190 gtg gcc aca gtc agt ttc ttc tgg gag gag agc ttg acc cag cac gtg 683 Val Ala Thr Val Ser Phe Phe Trp Glu Glu Ser Leu Thr Gln His Val 195 200 205 gct gga ctc ctg ttc ctc atg aca ggg ata ttt tgc acc att tcc ctc 731 Ala Gly Leu Leu Phe Leu Met Thr Gly Ile Phe Cys Thr Ile Ser Leu 210 215 220 225 tgt act tat gcc gcc agt atc tcg tat gat ttg aac cgg ctc cca aag 779 Cys Thr Tyr Ala Ala Ser Ile Ser Tyr Asp Leu Asn Arg Leu Pro Lys 230 235 240 cta att tat agc ctg cct gct gat gtg gaa cat ggt tac agc tgg tcc 827 Leu Ile Tyr Ser Leu Pro Ala Asp Val Glu His Gly Tyr Ser Trp Ser 245 250 255 atc ttt tgc gcc tgg tgc agt tta ggc ttt att gtg gca gct gga ggt 875 Ile Phe Cys Ala Trp Cys Ser Leu Gly Phe Ile Val Ala Ala Gly Gly 260 265 270 ctc tgc atc gct tat ccg ttt att agc cgg acc aag att gca cag cta 923 Leu Cys Ile Ala Tyr Pro Phe Ile Ser Arg Thr Lys Ile Ala Gln Leu 275 280 285 aag tct ggc aga gac tcc acg gta tgactgtcct cactgggcct gtccacagtg 977 Lys Ser Gly Arg Asp Ser Thr Val 290 295 cgagcgactc ctgaggggaa cagcgcggag ttcaggagtc caagcacaaa gcggtctttt 1037 acattccaac ctgttgcctg ccagcccttt ctggattact gatagaaaat catgcaaaac 1097 ctcccaacct ttctaaggac aagactactg tggattcaag tgctttaatg actatttatg 1157 cgttgactgt gagaataggg agcagtgcca tgggacattt ctaggtgtag agaaagaaga 1217 aactgcaatg gaaaaatttg tatgatttcc atttatttca gaaagtttgt atgtaacaat 1277 tacccgagag tcatttctac ttgcaaaagg attcgtaaca aagcgagtat aattttcttg 1337 tcattgtatc atgcttgtta aattttaatg cagcatcttc agaacttgtc ctgatggtgt 1397 cttattgtgt cagcaccaaa tatttgtgca ttatttgtgg acgttccttg tcacaggaag 1457 attcttcttc tgttgcctta ttgttttttt ttttaagtct cttctctgtc tttgtactgg 1517 aatcgaaatc ataagataaa cagatcaaac gtgcttaaga gctaactcgt gacactatgc 1577 agtattgttt gaagacctgt tgttcaacct ctgtctcttt atgttaactg gatttctgca 1637 ttaaatgact gcccccttgt t 1658 <210> 144 <211> 297 <212> PRT <213> Homo sapiens <400> 144 Met Glu Pro Arg Ala Leu Val Thr Ala Leu Ser Leu Gly Leu Ser Leu 1 5 10 15 Cys Ser Leu Gly Leu Leu Val Thr Ala Ile Phe Thr Asp His Trp Tyr 20 25 30 Glu Thr Asp Pro Arg Arg His Lys Glu Ser Cys Glu Arg Ser Arg Ala 35 40 45 Gly Ala Asp Pro Pro Asp Gln Lys Asn Arg Leu Met Pro Leu Ser His 50 55 60 Leu Pro Leu Arg Asp Ser Pro Pro Leu Gly Arg Arg Leu Leu Pro Gly 65 70 75 80 Gly Pro Gly Arg Ala Asp Pro Glu Ser Trp Arg Ser Leu Leu Gly Leu 85 90 95 Gly Gly Leu Asp Ala Glu Cys Gly Arg Pro Leu Phe Ala Thr Tyr Ser 100 105 110 Gly Leu Trp Arg Lys Cys Tyr Phe Leu Gly Ile Asp Arg Asp Ile Asp 115 120 125 Thr Leu Ile Leu Lys Gly Ile Ala Gln Arg Cys Thr Ala Ile Lys Tyr 130 135 140 His Phe Ser Gln Pro Ile Arg Leu Arg Asn Ile Pro Phe Asn Leu Thr 145 150 155 160 Lys Thr Ile Gln Gln Asp Glu Trp His Leu Leu His Leu Arg Arg Ile 165 170 175 Thr Ala Gly Phe Leu Gly Met Ala Val Ala Val Leu Leu Cys Gly Cys 180 185 190 Ile Val Ala Thr Val Ser Phe Phe Trp Glu Glu Ser Leu Thr Gln His 195 200 205 Val Ala Gly Leu Leu Phe Leu Met Thr Gly Ile Phe Cys Thr Ile Ser 210 215 220 Leu Cys Thr Tyr Ala Ala Ser Ile Ser Tyr Asp Leu Asn Arg Leu Pro 225 230 235 240 Lys Leu Ile Tyr Ser Leu Pro Ala Asp Val Glu His Gly Tyr Ser Trp 245 250 255 Ser Ile Phe Cys Ala Trp Cys Ser Leu Gly Phe Ile Val Ala Ala Gly 260 265 270 Gly Leu Cys Ile Ala Tyr Pro Phe Ile Ser Arg Thr Lys Ile Ala Gln 275 280 285 Leu Lys Ser Gly Arg Asp Ser Thr Val 290 295 <210> 145 <211> 2023 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (71)..(790) <400> 145 gcggatcact gaggctgtgg cggcactgcg cccggcgctc gcgtccgtcc gcccgtccgc 60 ccgcccagcc atg act gcg ccg gtc ccc gcg ccg cgg atc ctg ttg ccg 109 Met Thr Ala Pro Val Pro Ala Pro Arg Ile Leu Leu Pro 1 5 10 ttg ctg ttg ctg ctg ctg cta acg ccg cct ccg ggt gca cgt ggt gag 157 Leu Leu Leu Leu Leu Leu Leu Thr Pro Pro Pro Gly Ala Arg Gly Glu 15 20 25 gtg tgt atg gct tcc cgt gga ctc agc ctc ttc ccc gag tcc tgt cca 205 Val Cys Met Ala Ser Arg Gly Leu Ser Leu Phe Pro Glu Ser Cys Pro 30 35 40 45 gat ttc tgc tgt ggt acc tgt gat gac caa tac tgc tgc tct gac gtg 253 Asp Phe Cys Cys Gly Thr Cys Asp Asp Gln Tyr Cys Cys Ser Asp Val 50 55 60 ctg aag aaa ttt gtg tgg agc gag gaa agg tgt gct gtg cct gag gcc 301 Leu Lys Lys Phe Val Trp Ser Glu Glu Arg Cys Ala Val Pro Glu Ala 65 70 75 agc gtg cct gcc agt gta gag ccg gtg gag cag ctg ggc tcg gcg ctg 349 Ser Val Pro Ala Ser Val Glu Pro Val Glu Gln Leu Gly Ser Ala Leu 80 85 90 agg ttt cgc cct ggc tac aac gac ccc atg tca ggg ttc gga gcg acc 397 Arg Phe Arg Pro Gly Tyr Asn Asp Pro Met Ser Gly Phe Gly Ala Thr 95 100 105 ttg gcc gtt ggc ctg acc atc ttt gtg ctg tct gtc gtc act atc atc 445 Leu Ala Val Gly Leu Thr Ile Phe Val Leu Ser Val Val Thr Ile Ile 110 115 120 125 atc tgc ttc acc tgc tcc tgc tgc tgc ctt tac aag acg tgc cgc cga 493 Ile Cys Phe Thr Cys Ser Cys Cys Cys Leu Tyr Lys Thr Cys Arg Arg 130 135 140 cca cgt ccg gtt gtc acc acc acc aca tcc acc act gtg gtg cat gcc 541 Pro Arg Pro Val Val Thr Thr Thr Thr Ser Thr Thr Val Val His Ala 145 150 155 cct tat cct cag cct cca agt gtg ccg ccc agc tac cct gga cca agc 589 Pro Tyr Pro Gln Pro Pro Ser Val Pro Pro Ser Tyr Pro Gly Pro Ser 160 165 170 tac cag ggc tac cac acc atg ccg cct cag cca ggg atg cca gca gca 637 Tyr Gln Gly Tyr His Thr Met Pro Pro Gln Pro Gly Met Pro Ala Ala 175 180 185 ccc tac cca atg cag tac cca cca cct tac cca gcc cag ccc atg ggc 685 Pro Tyr Pro Met Gln Tyr Pro Pro Pro Tyr Pro Ala Gln Pro Met Gly 190 195 200 205 cca ccg gcc tac cac gag acc ctg gct gga gga gca gcc gcg ccc tac 733 Pro Pro Ala Tyr His Glu Thr Leu Ala Gly Gly Ala Ala Ala Pro Tyr 210 215 220 ccc gcc agc cag cct cct tac aac ccg gcc tac atg gat gcc ccg aag 781 Pro Ala Ser Gln Pro Pro Tyr Asn Pro Ala Tyr Met Asp Ala Pro Lys 225 230 235 gcg gcc ctc tgagcattcc ctggcctctc tggctgccac ttggttatgt 830 Ala Ala Leu 240 tgtgtgtgtg cgtgagtggt gtgcaggcgc ggttccttac gccccatgtg tgctgtgtgt 890 gtccaggcac ggttccttac gccccatgtg tgctgtgtgt gtcctgcctg tatatgtggc 950 ttcctctgat gctgacaagg tggggaacaa tccttgccag agtgggctgg gaccagactt 1010 tgttctcttc ctcacctgaa attatgcttc ctaaaatctc aagccaaact caaagaatgg 1070 ggtggtgggg ggcaccctgt gaggtggccc ctgagaggtg ggggcctctc cagggcacat 1130 ctggagttct tctccagctt accctagggt gaccaagtag ggcctgtcac accagggtgg 1190 cgcagctttc tgtgtgatgc agatgtgtcc tggtttcggc agcgtagcca gctgctgctt 1250 gaggccatgg ctcgtccccg gagttggggg tacccgttgc agagccaggg acatgatgca 1310 ggcgaagctt gggatctggc caagttggac tttgatcctt tgggcagatg tcccattgct 1370 ccctggagcc tgtcatgcct gttggggatc aggcagcctc ctgatgccag aacacctcag 1430 gcagagccct actcagctgt acctgtctgc ctggactgtc ccctgtcccc gcatctcccc 1490 tgggaccagc tggagggcca catgcacaca cagcctagct gcccccaggg agctctgctg 1550 cccttgctgg ccctgccctt cccacaggtg agcagggctc ctgtccacca gcacactcag 1610 ttctcttccc tgcagtgttt tcattttatt ttagccaaac attttgcctg ttttctgttt 1670 caaacatgat agttgatatg agactgaaac ccctgggttg tggagggaaa ttggctcaga 1730 gatggacaac ctggcaactg tgagtccctg cttcccgaca ccagcctcat ggaatatgca 1790 acaactcctg taccccagtc cacggtgttc tggcagcagg gacacctggg ccaatgggcc 1850 atctggacca aaggtggggt gtggggccct ggatggcagc tctggcccag acatgaatac 1910 ctcgtgttcc tcctccctct attactgttt caccagagct gtcttagctc aaatctgttg 1970 tgtttctgag tctagggtct gtacacttgt ttataataaa tgcaatcgtt tgg 2023 <210> 146 <211> 240 <212> PRT <213> Homo sapiens <400> 146 Met Thr Ala Pro Val Pro Ala Pro Arg Ile Leu Leu Pro Leu Leu Leu 1 5 10 15 Leu Leu Leu Leu Thr Pro Pro Pro Gly Ala Arg Gly Glu Val Cys Met 20 25 30 Ala Ser Arg Gly Leu Ser Leu Phe Pro Glu Ser Cys Pro Asp Phe Cys 35 40 45 Cys Gly Thr Cys Asp Asp Gln Tyr Cys Cys Ser Asp Val Leu Lys Lys 50 55 60 Phe Val Trp Ser Glu Glu Arg Cys Ala Val Pro Glu Ala Ser Val Pro 65 70 75 80 Ala Ser Val Glu Pro Val Glu Gln Leu Gly Ser Ala Leu Arg Phe Arg 85 90 95 Pro Gly Tyr Asn Asp Pro Met Ser Gly Phe Gly Ala Thr Leu Ala Val 100 105 110 Gly Leu Thr Ile Phe Val Leu Ser Val Val Thr Ile Ile Ile Cys Phe 115 120 125 Thr Cys Ser Cys Cys Cys Leu Tyr Lys Thr Cys Arg Arg Pro Arg Pro 130 135 140 Val Val Thr Thr Thr Thr Ser Thr Thr Val Val His Ala Pro Tyr Pro 145 150 155 160 Gln Pro Pro Ser Val Pro Pro Ser Tyr Pro Gly Pro Ser Tyr Gln Gly 165 170 175 Tyr His Thr Met Pro Pro Gln Pro Gly Met Pro Ala Ala Pro Tyr Pro 180 185 190 Met Gln Tyr Pro Pro Pro Tyr Pro Ala Gln Pro Met Gly Pro Pro Ala 195 200 205 Tyr His Glu Thr Leu Ala Gly Gly Ala Ala Ala Pro Tyr Pro Ala Ser 210 215 220 Gln Pro Pro Tyr Asn Pro Ala Tyr Met Asp Ala Pro Lys Ala Ala Leu 225 230 235 240 <210> 147 <211> 1898 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (403)..(834) <400> 147 atataaaata actgaaatct ggaactaatc aactgtgaaa atcaagcaac gagaaagagt 60 tgtaaattat tttaaaatat ctggctcgat caactttgcc agttttagag ccagtctttg 120 caaaaaggga gaaacaaaac agatgagaca agaaaggaac atccagcatg ctgtgaaccc 180 cctgagactg gccatgatct gaaagagtaa agctctatcc agggaacctt ttctgaatca 240 tagtgtcaga cttcctgctc ttttcaactc ccctggtttt atcatctcta ctctgtttca 300 gcaatctact gccatggcca catcctgaat gttgacaata ccctaaactg tgccatttat 360 aagatctctg acacaccaac ctctctcctc ttacagctct ca atg atg tat atg 414 Met Met Tyr Met 1 acc tca gct tat tct aat atg ctt aca gat tat aca ccc gtg ata ttg 462 Thr Ser Ala Tyr Ser Asn Met Leu Thr Asp Tyr Thr Pro Val Ile Leu 5 10 15 20 atg gca gtg gct gct gct gtc gtg gct gct gct atc acg cct gct gca 510 Met Ala Val Ala Ala Ala Val Val Ala Ala Ala Ile Thr Pro Ala Ala 25 30 35 aca cag agg tgc gac tgg ggc tgc aca ttt cac gga ggt gtt ggg agt 558 Thr Gln Arg Cys Asp Trp Gly Cys Thr Phe His Gly Gly Val Gly Ser 40 45 50 tcc gcc cct tct gat gtg ggg aaa gag atc ccc agg tgc ccc tgc atc 606 Ser Ala Pro Ser Asp Val Gly Lys Glu Ile Pro Arg Cys Pro Cys Ile 55 60 65 tgc cca aac tgt ggc tgt gga tcg gag gct cca ggt tgg cag gtt ggg 654 Cys Pro Asn Cys Gly Cys Gly Ser Glu Ala Pro Gly Trp Gln Val Gly 70 75 80 agc ttc cgg gtg cag ctg cga ccg ccc tcc cag gtg cag gac cct ggt 702 Ser Phe Arg Val Gln Leu Arg Pro Pro Ser Gln Val Gln Asp Pro Gly 85 90 95 100 gtt tct gca gcc tgc acc ctt ggg ggc ccc agg aaa gac cca tat cct 750 Val Ser Ala Ala Cys Thr Leu Gly Gly Pro Arg Lys Asp Pro Tyr Pro 105 110 115 tgc agg ctt gga ggt gtt tgc ttc ttc tgc ctg gcc tct ctc ggc tcc 798 Cys Arg Leu Gly Gly Val Cys Phe Phe Cys Leu Ala Ser Leu Gly Ser 120 125 130 cgg tgc atg ctc tca tat ctg agt ggg ggt tgg tgc tgagccccgg 844 Arg Cys Met Leu Ser Tyr Leu Ser Gly Gly Trp Cys 135 140 ggccgtgaat tgcagcagga ggcagattta ttcctgggca gaaggtggca gatcccaagt 904 aaggggacct tcaagccagg gagggcctga aggctggtgg ctgggctacc agtcccaccg 964 accagagtgg ggattcgtgg gcctcttctg ggccacccat agccacccat ggaccaatca 1024 gcaagcacat cctcccctct gaggtccgta aaagccctgg gcgcagcctg agcagggcag 1084 aggaaggcca gaggtgaagg agtcagagag gcgacaggat aggcagctgc cgagagaagt 1144 acgcctctct gctgagacct ggagatgacg ggaaggccag atgcagagag gagctaccct 1204 ctctgcttag agctgccagg aggagctacc aaccttctct gctgagagct gcagagatga 1264 cctgctggca gagaggagct acccactgcg ggtctcctct gatctgttgt aatgctgaat 1324 aaagcttctt ttcatcttgt tcaccttcca cttgtctgca tacctcattc tacccggacg 1384 caagcaagaa ctcgagcaaa ggcacaacca gccacagagg tttctggcca gaaaatcgac 1444 accccaaaag tcctataaca atctgattct aaaagcaaca tcatcttttc aatgtaattc 1504 taaaagaatt tgggattatt ttatttaatt tcaggatccc ctctgaagaa aatcaactta 1564 caaaggatgg caggtcttaa gaaaggtact tagcaagtgc tggtacattc taagcaatca 1624 atatttgtca atgttcagta attgtacaat tgtactagag aaaacaattc caggggctta 1684 aaattatctt atacaaggat ccactttatt attatttttt ctgtttgttt tggataaatt 1744 actgactcct tatctcagtt atgttatgtg ttaaatgttt acagtgttat tttgtatctc 1804 tcaagggctt ttgttagaat tttcaatgag ataccttaaa acctctaaaa agaaaatgga 1864 tgttataagt aaataaaaat aagtctgaat ggcc 1898 <210> 148 <211> 144 <212> PRT <213> Homo sapiens <400> 148 Met Met Tyr Met Thr Ser Ala Tyr Ser Asn Met Leu Thr Asp Tyr Thr 1 5 10 15 Pro Val Ile Leu Met Ala Val Ala Ala Ala Val Val Ala Ala Ala Ile 20 25 30 Thr Pro Ala Ala Thr Gln Arg Cys Asp Trp Gly Cys Thr Phe His Gly 35 40 45 Gly Val Gly Ser Ser Ala Pro Ser Asp Val Gly Lys Glu Ile Pro Arg 50 55 60 Cys Pro Cys Ile Cys Pro Asn Cys Gly Cys Gly Ser Glu Ala Pro Gly 65 70 75 80 Trp Gln Val Gly Ser Phe Arg Val Gln Leu Arg Pro Pro Ser Gln Val 85 90 95 Gln Asp Pro Gly Val Ser Ala Ala Cys Thr Leu Gly Gly Pro Arg Lys 100 105 110 Asp Pro Tyr Pro Cys Arg Leu Gly Gly Val Cys Phe Phe Cys Leu Ala 115 120 125 Ser Leu Gly Ser Arg Cys Met Leu Ser Tyr Leu Ser Gly Gly Trp Cys 130 135 140 <210> 149 <211> 1755 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (201)..(1166) <400> 149 attcatttcc cccagtgacc ttgacaagtc agaagcttga aagcagggaa atccggatgt 60 ctcggttatg aagtggagca gtgagtgtga gcctcaacat agttccagaa ctctccatcc 120 ggactagtta ttgagcatct gcctctcata tcaccagtgg ccatctgagg tgtttccctg 180 gctctgaagg ggtaggcacg atg gcc agg tgc ttc agc ctg gtg ttg ctt ctc 233 Met Ala Arg Cys Phe Ser Leu Val Leu Leu Leu 1 5 10 act tcc atc tgg acc acg agg ctc ctg gtc caa ggc tct ttg cgt gca 281 Thr Ser Ile Trp Thr Thr Arg Leu Leu Val Gln Gly Ser Leu Arg Ala 15 20 25 gaa gag ctt tcc atc cag gtg tca tgc aga att atg ggg atc acc ctt 329 Glu Glu Leu Ser Ile Gln Val Ser Cys Arg Ile Met Gly Ile Thr Leu 30 35 40 gtg agc aaa aag gcg aac cag cag ctg aat ttc aca gaa gct aag gag 377 Val Ser Lys Lys Ala Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu 45 50 55 gcc tgt agg ctg ctg gga cta agt ttg gcc ggc aag gac caa gtt gaa 425 Ala Cys Arg Leu Leu Gly Leu Ser Leu Ala Gly Lys Asp Gln Val Glu 60 65 70 75 aca gcc ttg aaa gct agc ttt gaa act tgc agc tat ggc tgg gtt gga 473 Thr Ala Leu Lys Ala Ser Phe Glu Thr Cys Ser Tyr Gly Trp Val Gly 80 85 90 gat gga ttc gtg gtc atc tct agg att agc cca aac ccc aag tgt ggg 521 Asp Gly Phe Val Val Ile Ser Arg Ile Ser Pro Asn Pro Lys Cys Gly 95 100 105 aaa aat ggg gtg ggt gtc ctg att tgg aag gtt cca gtg agc cga cag 569 Lys Asn Gly Val Gly Val Leu Ile Trp Lys Val Pro Val Ser Arg Gln 110 115 120 ttt gca gcc tat tgt tac aac tca tct gat act tgg act aac tcg tgc 617 Phe Ala Ala Tyr Cys Tyr Asn Ser Ser Asp Thr Trp Thr Asn Ser Cys 125 130 135 att cca gaa att atc acc acc aaa gat ccc ata ttc aac act caa act 665 Ile Pro Glu Ile Ile Thr Thr Lys Asp Pro Ile Phe Asn Thr Gln Thr 140 145 150 155 gca aca caa aca aca gaa ttt att gtc agt gac agt acc tac tcg gtg 713 Ala Thr Gln Thr Thr Glu Phe Ile Val Ser Asp Ser Thr Tyr Ser Val 160 165 170 gca tcc cct tac tct aca ata cct gcc cct act act act cct cct gct 761 Ala Ser Pro Tyr Ser Thr Ile Pro Ala Pro Thr Thr Thr Pro Pro Ala 175 180 185 cca gct tcc act tct att cca cgg aga aaa aaa ttg att tgt gtc aca 809 Pro Ala Ser Thr Ser Ile Pro Arg Arg Lys Lys Leu Ile Cys Val Thr 190 195 200 gaa gtt ttt atg gaa act agc acc atg tct aca gaa act gaa cca ttt 857 Glu Val Phe Met Glu Thr Ser Thr Met Ser Thr Glu Thr Glu Pro Phe 205 210 215 gtt gaa aat aaa gca gca ttc aag aat gaa gct gct ggg ttt gga ggt 905 Val Glu Asn Lys Ala Ala Phe Lys Asn Glu Ala Ala Gly Phe Gly Gly 220 225 230 235 gtc ccc acg gct ctg cta gtg ctt gct ctc ctc ttc ttt ggt gct gca 953 Val Pro Thr Ala Leu Leu Val Leu Ala Leu Leu Phe Phe Gly Ala Ala 240 245 250 gct ggt ctt gga ttt tgc tat gtc aaa agg tat gtg aag gcc ttc cct 1001 Ala Gly Leu Gly Phe Cys Tyr Val Lys Arg Tyr Val Lys Ala Phe Pro 255 260 265 ttt aca aac aag aat cag cag aag gaa atg atc gaa acc aaa gta gta 1049 Phe Thr Asn Lys Asn Gln Gln Lys Glu Met Ile Glu Thr Lys Val Val 270 275 280 aag gag gag aag gcc aat gat agc aac cct aat gag gaa tca aag aaa 1097 Lys Glu Glu Lys Ala Asn Asp Ser Asn Pro Asn Glu Glu Ser Lys Lys 285 290 295 act gat aaa aac cca gaa gag tcc aag agt cca agc aaa act acc gtg 1145 Thr Asp Lys Asn Pro Glu Glu Ser Lys Ser Pro Ser Lys Thr Thr Val 300 305 310 315 cga tgc ctg gaa gct gaa gtt tagatgagac agaaatgagg agacacacct 1196 Arg Cys Leu Glu Ala Glu Val 320 gaggctggtt tctttcatgc tccttaccct gccccagctg gggaaatcaa aagggccaaa 1256 gaaccaaaga agaaagtcca cccttggttc ctaactggaa tcagctcagg actgccattg 1316 gactatggag tgcaccaaag agaatgccct tctccttatt gtaaccctgt ctggatccta 1376 tcctcctacc tccaaagctt cccacggcct ttctagcctg gctatgtcct aataatatcc 1436 cactgggaga aaggagtttt gcaaagtgca aggacctaaa acatctcatc agtatccagt 1496 ggtaaaaagg cctcctggct gtctgaggct aggtgggttg aaagccaagg agtcactgag 1556 accaaggctt tctctactga ttccgcagct cagacccttt cttcagctct gaaagagaaa 1616 cacgtatccc acctgacatg tccttctgag cccggtaagg gcaaaagaat ggcagaaaag 1676 tttagcccct gaaagccatg gagattctca taacttgaga cctaatctct gtaaagctaa 1736 aataaagaaa tagaacaag 1755 <210> 150 <211> 322 <212> PRT <213> Homo sapiens <400> 150 Met Ala Arg Cys Phe Ser Leu Val Leu Leu Leu Thr Ser Ile Trp Thr 1 5 10 15 Thr Arg Leu Leu Val Gln Gly Ser Leu Arg Ala Glu Glu Leu Ser Ile 20 25 30 Gln Val Ser Cys Arg Ile Met Gly Ile Thr Leu Val Ser Lys Lys Ala 35 40 45 Asn Gln Gln Leu Asn Phe Thr Glu Ala Lys Glu Ala Cys Arg Leu Leu 50 55 60 Gly Leu Ser Leu Ala Gly Lys Asp Gln Val Glu Thr Ala Leu Lys Ala 65 70 75 80 Ser Phe Glu Thr Cys Ser Tyr Gly Trp Val Gly Asp Gly Phe Val Val 85 90 95 Ile Ser Arg Ile Ser Pro Asn Pro Lys Cys Gly Lys Asn Gly Val Gly 100 105 110 Val Leu Ile Trp Lys Val Pro Val Ser Arg Gln Phe Ala Ala Tyr Cys 115 120 125 Tyr Asn Ser Ser Asp Thr Trp Thr Asn Ser Cys Ile Pro Glu Ile Ile 130 135 140 Thr Thr Lys Asp Pro Ile Phe Asn Thr Gln Thr Ala Thr Gln Thr Thr 145 150 155 160 Glu Phe Ile Val Ser Asp Ser Thr Tyr Ser Val Ala Ser Pro Tyr Ser 165 170 175 Thr Ile Pro Ala Pro Thr Thr Thr Pro Pro Ala Pro Ala Ser Thr Ser 180 185 190 Ile Pro Arg Arg Lys Lys Leu Ile Cys Val Thr Glu Val Phe Met Glu 195 200 205 Thr Ser Thr Met Ser Thr Glu Thr Glu Pro Phe Val Glu Asn Lys Ala 210 215 220 Ala Phe Lys Asn Glu Ala Ala Gly Phe Gly Gly Val Pro Thr Ala Leu 225 230 235 240 Leu Val Leu Ala Leu Leu Phe Phe Gly Ala Ala Ala Gly Leu Gly Phe 245 250 255 Cys Tyr Val Lys Arg Tyr Val Lys Ala Phe Pro Phe Thr Asn Lys Asn 260 265 270 Gln Gln Lys Glu Met Ile Glu Thr Lys Val Val Lys Glu Glu Lys Ala 275 280 285 Asn Asp Ser Asn Pro Asn Glu Glu Ser Lys Lys Thr Asp Lys Asn Pro 290 295 300 Glu Glu Ser Lys Ser Pro Ser Lys Thr Thr Val Arg Cys Leu Glu Ala 305 310 315 320 Glu Val <210> 151 <211> 1907 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (21)..(1196) <400> 151 ctgcagtagg tctgccggcg atg gag tgg tgg gct agc tcg ccg ctt cgg ctc 53 Met Glu Trp Trp Ala Ser Ser Pro Leu Arg Leu 1 5 10 tgg ctg ctg ttg ttc ctc ctg ccc tca gcg cag ggc cgc cag aag gag 101 Trp Leu Leu Leu Phe Leu Leu Pro Ser Ala Gln Gly Arg Gln Lys Glu 15 20 25 tca ggt tca aaa tgg aaa gta ttt att gac caa att aac agg tct ttg 149 Ser Gly Ser Lys Trp Lys Val Phe Ile Asp Gln Ile Asn Arg Ser Leu 30 35 40 gag aat tac gaa cca tgt tca agt caa aac tgc agc tgc tac cat ggt 197 Glu Asn Tyr Glu Pro Cys Ser Ser Gln Asn Cys Ser Cys Tyr His Gly 45 50 55 gtc ata gaa gag gat cta act cct ttc cga gga ggc atc tcc agg aag 245 Val Ile Glu Glu Asp Leu Thr Pro Phe Arg Gly Gly Ile Ser Arg Lys 60 65 70 75 atg atg gca gag gta gtc aga cgg aag cta ggg acc cac tat cag atc 293 Met Met Ala Glu Val Val Arg Arg Lys Leu Gly Thr His Tyr Gln Ile 80 85 90 act aag aac aga ctg tac cgg gaa aat gac tgc atg ttc ccc tca agg 341 Thr Lys Asn Arg Leu Tyr Arg Glu Asn Asp Cys Met Phe Pro Ser Arg 95 100 105 tgt agt ggt gtt gag cac ttt att ttg gaa gtg atc ggg cgt ctc cct 389 Cys Ser Gly Val Glu His Phe Ile Leu Glu Val Ile Gly Arg Leu Pro 110 115 120 gac atg gag atg gtg atc aat gta cga gat tat cct cag gtt cct aaa 437 Asp Met Glu Met Val Ile Asn Val Arg Asp Tyr Pro Gln Val Pro Lys 125 130 135 tgg atg gag cct gcc atc cca gtc ttc tcc ttc agt aag aca tca gag 485 Trp Met Glu Pro Ala Ile Pro Val Phe Ser Phe Ser Lys Thr Ser Glu 140 145 150 155 tac cat gat atc atg tat cct gct tgg aca ttt tgg gaa ggg gga cct 533 Tyr His Asp Ile Met Tyr Pro Ala Trp Thr Phe Trp Glu Gly Gly Pro 160 165 170 gct gtt tgg cca att tat cct aca ggt ctt gga cgg tgg gac ctc ttc 581 Ala Val Trp Pro Ile Tyr Pro Thr Gly Leu Gly Arg Trp Asp Leu Phe 175 180 185 aga gaa gat ctg gta agg tca gca gca cag tgg cca tgg aaa aag aaa 629 Arg Glu Asp Leu Val Arg Ser Ala Ala Gln Trp Pro Trp Lys Lys Lys 190 195 200 aac tct aca gca tat ttc cga gga tca agg aca agt cca gaa cga gat 677 Asn Ser Thr Ala Tyr Phe Arg Gly Ser Arg Thr Ser Pro Glu Arg Asp 205 210 215 cct ctc att ctt ctg tct cgg aaa aac cca aaa ctt gtt gat gca gaa 725 Pro Leu Ile Leu Leu Ser Arg Lys Asn Pro Lys Leu Val Asp Ala Glu 220 225 230 235 tac acc aaa aac cag gcc tgg aaa tct atg aaa gat acc tta gga aag 773 Tyr Thr Lys Asn Gln Ala Trp Lys Ser Met Lys Asp Thr Leu Gly Lys 240 245 250 cca gct gct aag gat gtc cat ctt gtg gat cac tgc aaa tac aag tac 821 Pro Ala Ala Lys Asp Val His Leu Val Asp His Cys Lys Tyr Lys Tyr 255 260 265 ctg ttt aat ttt cga ggc gta gct gca agt ttc cgg ttt aaa cac ctc 869 Leu Phe Asn Phe Arg Gly Val Ala Ala Ser Phe Arg Phe Lys His Leu 270 275 280 ttc ctg tgt ggc tca ctt gtt ttc cat gtt ggt gat gag tgg cta gaa 917 Phe Leu Cys Gly Ser Leu Val Phe His Val Gly Asp Glu Trp Leu Glu 285 290 295 ttc ttc tat cca cag ctg aag cca tgg gtt cac tat atc cca gtc aaa 965 Phe Phe Tyr Pro Gln Leu Lys Pro Trp Val His Tyr Ile Pro Val Lys 300 305 310 315 aca gat ctc tcc aat gtc caa gag ctg tta caa ttt gta aaa gca aat 1013 Thr Asp Leu Ser Asn Val Gln Glu Leu Leu Gln Phe Val Lys Ala Asn 320 325 330 gat gat gta gct caa gag att gct gaa agg gga agc cag ttt att agg 1061 Asp Asp Val Ala Gln Glu Ile Ala Glu Arg Gly Ser Gln Phe Ile Arg 335 340 345 aac cat ttg cag atg gat gac atc acc tgt tac tgg gag aac ctc ttg 1109 Asn His Leu Gln Met Asp Asp Ile Thr Cys Tyr Trp Glu Asn Leu Leu 350 355 360 agt gaa tac tct aaa ttc ctg tct tat aat gta acg aga agg aaa ggt 1157 Ser Glu Tyr Ser Lys Phe Leu Ser Tyr Asn Val Thr Arg Arg Lys Gly 365 370 375 tat gat caa att att ccc aaa atg ttg aaa act gaa cta tagtagtcat 1206 Tyr Asp Gln Ile Ile Pro Lys Met Leu Lys Thr Glu Leu 380 385 390 cataggacca tagtcctctt tgtggcaaca gatctcagat atcctacggt gagaagctta 1266 ccataagctt ggcacctata ccttgaatat ctgctatcaa gccaaatacc tggttttcct 1326 tatcatgctg cacccagagc aactcttgag aaagatttaa aatgtgtcta atacactgat 1386 atgaagcagt tcaacttttt ggatgaataa ggaccagaaa tcgtgagatg tggattttga 1446 acccaactct acctttcatt ttcttaagac caatcacagc ttgtgcctca gatcatccac 1506 ctgtgtgagt ccatcactgt gaaattgact gtgtccatgt gatgatgccc tttgtcccat 1566 tatttggagc agaaaattcg tcatttggaa gtagtacaac tcattgctgt aattgtgaaa 1626 ttattcaagg cgtgatctct gtcactttat tttaatgtag gaaaccctat ggggtttatg 1686 aaaaatactt ggggatcatt ctctgaatgg tctaaggaag cggtagccat gccatgcaat 1746 gatgtaggag ttctcttttg taaaaccata aactgtgtta ctcaggaggt ttctataatg 1806 ccacatagaa agaggccaat tgcatgagta attattgcaa ttggatttca ggttcccttt 1866 ttgtgccttc atgccctact tcttaatgcc tctctaaagc c 1907 <210> 152 <211> 392 <212> PRT <213> Homo sapiens <400> 152 Met Glu Trp Trp Ala Ser Ser Pro Leu Arg Leu Trp Leu Leu Leu Phe 1 5 10 15 Leu Leu Pro Ser Ala Gln Gly Arg Gln Lys Glu Ser Gly Ser Lys Trp 20 25 30 Lys Val Phe Ile Asp Gln Ile Asn Arg Ser Leu Glu Asn Tyr Glu Pro 35 40 45 Cys Ser Ser Gln Asn Cys Ser Cys Tyr His Gly Val Ile Glu Glu Asp 50 55 60 Leu Thr Pro Phe Arg Gly Gly Ile Ser Arg Lys Met Met Ala Glu Val 65 70 75 80 Val Arg Arg Lys Leu Gly Thr His Tyr Gln Ile Thr Lys Asn Arg Leu 85 90 95 Tyr Arg Glu Asn Asp Cys Met Phe Pro Ser Arg Cys Ser Gly Val Glu 100 105 110 His Phe Ile Leu Glu Val Ile Gly Arg Leu Pro Asp Met Glu Met Val 115 120 125 Ile Asn Val Arg Asp Tyr Pro Gln Val Pro Lys Trp Met Glu Pro Ala 130 135 140 Ile Pro Val Phe Ser Phe Ser Lys Thr Ser Glu Tyr His Asp Ile Met 145 150 155 160 Tyr Pro Ala Trp Thr Phe Trp Glu Gly Gly Pro Ala Val Trp Pro Ile 165 170 175 Tyr Pro Thr Gly Leu Gly Arg Trp Asp Leu Phe Arg Glu Asp Leu Val 180 185 190 Arg Ser Ala Ala Gln Trp Pro Trp Lys Lys Lys Asn Ser Thr Ala Tyr 195 200 205 Phe Arg Gly Ser Arg Thr Ser Pro Glu Arg Asp Pro Leu Ile Leu Leu 210 215 220 Ser Arg Lys Asn Pro Lys Leu Val Asp Ala Glu Tyr Thr Lys Asn Gln 225 230 235 240 Ala Trp Lys Ser Met Lys Asp Thr Leu Gly Lys Pro Ala Ala Lys Asp 245 250 255 Val His Leu Val Asp His Cys Lys Tyr Lys Tyr Leu Phe Asn Phe Arg 260 265 270 Gly Val Ala Ala Ser Phe Arg Phe Lys His Leu Phe Leu Cys Gly Ser 275 280 285 Leu Val Phe His Val Gly Asp Glu Trp Leu Glu Phe Phe Tyr Pro Gln 290 295 300 Leu Lys Pro Trp Val His Tyr Ile Pro Val Lys Thr Asp Leu Ser Asn 305 310 315 320 Val Gln Glu Leu Leu Gln Phe Val Lys Ala Asn Asp Asp Val Ala Gln 325 330 335 Glu Ile Ala Glu Arg Gly Ser Gln Phe Ile Arg Asn His Leu Gln Met 340 345 350 Asp Asp Ile Thr Cys Tyr Trp Glu Asn Leu Leu Ser Glu Tyr Ser Lys 355 360 365 Phe Leu Ser Tyr Asn Val Thr Arg Arg Lys Gly Tyr Asp Gln Ile Ile 370 375 380 Pro Lys Met Leu Lys Thr Glu Leu 385 390 <210> 153 <211> 2981 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (58)..(1770) <400> 153 gactgggttc gcggccgcgt gcagaggtgc aggcagagca gcctcggaac cgagacg 57 atg cgt gcg ctc cgc gac cga gcc ggg ctc ctc ctc tgc gtg ctg ctg 105 Met Arg Ala Leu Arg Asp Arg Ala Gly Leu Leu Leu Cys Val Leu Leu 1 5 10 15 ctg gcg gcg ctg ctg gag gcg gcg cta ggg ctc ccc gtg aag aag ccg 153 Leu Ala Ala Leu Leu Glu Ala Ala Leu Gly Leu Pro Val Lys Lys Pro 20 25 30 cgg ctc cgc gga cca cgg cct ggg agc ctc acg agg ctc gca gag gtc 201 Arg Leu Arg Gly Pro Arg Pro Gly Ser Leu Thr Arg Leu Ala Glu Val 35 40 45 tca gcc tcc cca gat cct agg cct ctg aag gaa gag gag gag gca cca 249 Ser Ala Ser Pro Asp Pro Arg Pro Leu Lys Glu Glu Glu Glu Ala Pro 50 55 60 ctg ctc ccc aga acc cac ctg cag gca gag cca cac caa cat gga tgc 297 Leu Leu Pro Arg Thr His Leu Gln Ala Glu Pro His Gln His Gly Cys 65 70 75 80 tgg act gtc act gag cca gca gcc atg acc cca ggc aac acc acc cct 345 Trp Thr Val Thr Glu Pro Ala Ala Met Thr Pro Gly Asn Thr Thr Pro 85 90 95 ccc agg acc cca gag gtt act ccg ttg cgg ctg gag ctg cag aag ctg 393 Pro Arg Thr Pro Glu Val Thr Pro Leu Arg Leu Glu Leu Gln Lys Leu 100 105 110 ccg gga ttg gcc agc aca acc ttg agt acc cct aac cct gat acc cag 441 Pro Gly Leu Ala Ser Thr Thr Leu Ser Thr Pro Asn Pro Asp Thr Gln 115 120 125 gct tca gcc tcc cca gat cct agg cct ctg agg gaa gag gag gag gca 489 Ala Ser Ala Ser Pro Asp Pro Arg Pro Leu Arg Glu Glu Glu Glu Ala 130 135 140 cga ctg ctc ccc aga acc cac ctg cag gca gag cta cac caa cat gga 537 Arg Leu Leu Pro Arg Thr His Leu Gln Ala Glu Leu His Gln His Gly 145 150 155 160 tgt tgg act gtc act gag cca gca gcc ctg acc cca ggg aat gcc acg 585 Cys Trp Thr Val Thr Glu Pro Ala Ala Leu Thr Pro Gly Asn Ala Thr 165 170 175 cct ccc agg acc cag gag gtt act ccc ttg ctg ctg gag ctg cag aag 633 Pro Pro Arg Thr Gln Glu Val Thr Pro Leu Leu Leu Glu Leu Gln Lys 180 185 190 ctg cca gaa ttg gtc cac gca acc ttg agt acc cct aac cct gat aac 681 Leu Pro Glu Leu Val His Ala Thr Leu Ser Thr Pro Asn Pro Asp Asn 195 200 205 cag gtg acc atc aag gtg gtg gag gac ccc cag gcc gag gtg tcg ata 729 Gln Val Thr Ile Lys Val Val Glu Asp Pro Gln Ala Glu Val Ser Ile 210 215 220 gac ctg ttg gct gag ccc agc aat ccc ccg ccc cag gat acc ctt agc 777 Asp Leu Leu Ala Glu Pro Ser Asn Pro Pro Pro Gln Asp Thr Leu Ser 225 230 235 240 tgg ctg ccc gcc ctc tgg ccc ttc ctc tgg gga gac tac aaa gga gag 825 Trp Leu Pro Ala Leu Trp Pro Phe Leu Trp Gly Asp Tyr Lys Gly Glu 245 250 255 gaa aaa gac agg gcc cca ggg gag aag ggg gag gaa aag gag gaa gac 873 Glu Lys Asp Arg Ala Pro Gly Glu Lys Gly Glu Glu Lys Glu Glu Asp 260 265 270 gag gac tat cct tca gag gat atc gag ggt gag gat caa gag gac aaa 921 Glu Asp Tyr Pro Ser Glu Asp Ile Glu Gly Glu Asp Gln Glu Asp Lys 275 280 285 gag gaa gat gag gaa gag cag gcg ctc tgg ttc aat gga act aca gac 969 Glu Glu Asp Glu Glu Glu Gln Ala Leu Trp Phe Asn Gly Thr Thr Asp 290 295 300 aac tgg gac cag ggc tgg ctg gcc ccc ggg gat tgg gtc ttc aag gat 1017 Asn Trp Asp Gln Gly Trp Leu Ala Pro Gly Asp Trp Val Phe Lys Asp 305 310 315 320 tct gtc agc tac gac tat gag cct cag aag gag tgg agt ccc tgg tct 1065 Ser Val Ser Tyr Asp Tyr Glu Pro Gln Lys Glu Trp Ser Pro Trp Ser 325 330 335 ccc tgc agt ggg aac tgc agc act ggc aag cag cag agg act cgg ccc 1113 Pro Cys Ser Gly Asn Cys Ser Thr Gly Lys Gln Gln Arg Thr Arg Pro 340 345 350 tgt ggc tat ggc tgc act gcc acc gag acc cgt acc tgt gac ctg ccc 1161 Cys Gly Tyr Gly Cys Thr Ala Thr Glu Thr Arg Thr Cys Asp Leu Pro 355 360 365 tcc tgt cct ggc act gag gac aag gac acc ttg ggc ctc ccc agt gag 1209 Ser Cys Pro Gly Thr Glu Asp Lys Asp Thr Leu Gly Leu Pro Ser Glu 370 375 380 gag tgg aag ctc ctg gcc cgc aat gct acg gac atg cat gat caa gat 1257 Glu Trp Lys Leu Leu Ala Arg Asn Ala Thr Asp Met His Asp Gln Asp 385 390 395 400 gtg gac agc tgt gag aag tgg ctg aac tgc aag agc gac ttc cta atc 1305 Val Asp Ser Cys Glu Lys Trp Leu Asn Cys Lys Ser Asp Phe Leu Ile 405 410 415 aag tat ctg agc cag atg ctg cgg gac ctg ccc agc tgc ccg tgt gcc 1353 Lys Tyr Leu Ser Gln Met Leu Arg Asp Leu Pro Ser Cys Pro Cys Ala 420 425 430 tac cca ctg gag gcc atg gac agc cct gtg agc cta cag gac gag cac 1401 Tyr Pro Leu Glu Ala Met Asp Ser Pro Val Ser Leu Gln Asp Glu His 435 440 445 cag ggc cgc agc ttc cgg tgg agg gat gcc agt ggc cct cgc gag cgc 1449 Gln Gly Arg Ser Phe Arg Trp Arg Asp Ala Ser Gly Pro Arg Glu Arg 450 455 460 ctg gac atc tac cag ccc acg gcg cgc ttc tgc ctg cgt tcc atg ctg 1497 Leu Asp Ile Tyr Gln Pro Thr Ala Arg Phe Cys Leu Arg Ser Met Leu 465 470 475 480 tct ggg gag agc agc aca ctg gcc gcc cag cac tgc tgc tat gac gag 1545 Ser Gly Glu Ser Ser Thr Leu Ala Ala Gln His Cys Cys Tyr Asp Glu 485 490 495 gac agc cgg ctg ctg acc cgt ggc aag ggc gcc ggc atg ccc aac ctc 1593 Asp Ser Arg Leu Leu Thr Arg Gly Lys Gly Ala Gly Met Pro Asn Leu 500 505 510 atc agc acc gac ttc tca cct aag ctg cac ttc aag ttc gac acg acg 1641 Ile Ser Thr Asp Phe Ser Pro Lys Leu His Phe Lys Phe Asp Thr Thr 515 520 525 ccc tgg atc ctg tgc aag ggg gac tgg agc cgc ctc cac gct gtg ctc 1689 Pro Trp Ile Leu Cys Lys Gly Asp Trp Ser Arg Leu His Ala Val Leu 530 535 540 cct ccc aac aac ggc cga gcc tgc acc gac aac ccc ctg gag gag gag 1737 Pro Pro Asn Asn Gly Arg Ala Cys Thr Asp Asn Pro Leu Glu Glu Glu 545 550 555 560 tac cta gca cag ttg cag gag gcc aag gag tac tagtgacggg gttgctgaac 1790 Tyr Leu Ala Gln Leu Gln Glu Ala Lys Glu Tyr 565 570 agacactgca gggagagggc aggcggctgc tgctgttgca cgggagaact ttcctggtag 1850 ggccctcacc cgcccctgcc cagacagggt gaggaaaggg ctcccccagt gaggttggtc 1910 cgaggctgtg tgccctctgc cagcgacccc gaagcagata tctcagtggg gttagtgaga 1970 aggttgaagg gtatgtaggg cccagggtgg gtgtccctgg gagccctgga aatgtgcata 2030 tgtgcatgtg tctgccgggg cctccctctg ctgcctgctg ggaccctggc cactcatttt 2090 tctcctcctt gggagctggg ctcttctgcc ctggctctgc acataagtgt tagccagcag 2150 ctccagaaaa atcccgattc ccgggatctg ccacgagtca ctcctactcc accctgatgg 2210 ccagcagagg aagggccact cttctcatgg gcacagccat cctttgccgg gggggcatcc 2270 agcccgggtg gccacccctc cttatctctg ggtggtgcac atgcccttct ttccccactc 2330 cctgccacga gccactgcac aggaggctat ctgtagcccc aagctgcctt tctgttggac 2390 accaacttta gtcttgggct gcaagccagc ccagctgagg cgaagtggac tccaggcagg 2450 gaatgggttg cccaattctg gtccctttcc tttgctcagc cccctctgtt ctgctgattg 2510 tagggatgtg cagggctggg agttggcact ccccccgagt ggggaggtga cagcttgtca 2570 cagtagccag gcttgggtgg gttcagcact agctcgggac ggtgtgtcac acgtctatag 2630 taaaccagtt ctctgggagg ggaaaaaagc cctgatttat tgcatttggg cagcttctgt 2690 ggtgtaaatt ctcccagcag tgtcccatgt catgctgcca gcatcactga atgcactgaa 2750 ctcagagttg ggaagagatg cacataatcg ctctcccggc acacctcatg cctcttccct 2810 gcctccccat tcccctggct gcacttcctt gccttctatg gggttgaaat gttgaagtct 2870 caactgtctc tgttcacaag agccaccaaa agttagggga cttcagtcct agcccccaga 2930 tggccgccct gaagctctct gggctcctca gcaataaagc actttatttt c 2981 <210> 154 <211> 571 <212> PRT <213> Homo sapiens <400> 154 Met Arg Ala Leu Arg Asp Arg Ala Gly Leu Leu Leu Cys Val Leu Leu 1 5 10 15 Leu Ala Ala Leu Leu Glu Ala Ala Leu Gly Leu Pro Val Lys Lys Pro 20 25 30 Arg Leu Arg Gly Pro Arg Pro Gly Ser Leu Thr Arg Leu Ala Glu Val 35 40 45 Ser Ala Ser Pro Asp Pro Arg Pro Leu Lys Glu Glu Glu Glu Ala Pro 50 55 60 Leu Leu Pro Arg Thr His Leu Gln Ala Glu Pro His Gln His Gly Cys 65 70 75 80 Trp Thr Val Thr Glu Pro Ala Ala Met Thr Pro Gly Asn Thr Thr Pro 85 90 95 Pro Arg Thr Pro Glu Val Thr Pro Leu Arg Leu Glu Leu Gln Lys Leu 100 105 110 Pro Gly Leu Ala Ser Thr Thr Leu Ser Thr Pro Asn Pro Asp Thr Gln 115 120 125 Ala Ser Ala Ser Pro Asp Pro Arg Pro Leu Arg Glu Glu Glu Glu Ala 130 135 140 Arg Leu Leu Pro Arg Thr His Leu Gln Ala Glu Leu His Gln His Gly 145 150 155 160 Cys Trp Thr Val Thr Glu Pro Ala Ala Leu Thr Pro Gly Asn Ala Thr 165 170 175 Pro Pro Arg Thr Gln Glu Val Thr Pro Leu Leu Leu Glu Leu Gln Lys 180 185 190 Leu Pro Glu Leu Val His Ala Thr Leu Ser Thr Pro Asn Pro Asp Asn 195 200 205 Gln Val Thr Ile Lys Val Val Glu Asp Pro Gln Ala Glu Val Ser Ile 210 215 220 Asp Leu Leu Ala Glu Pro Ser Asn Pro Pro Pro Gln Asp Thr Leu Ser 225 230 235 240 Trp Leu Pro Ala Leu Trp Pro Phe Leu Trp Gly Asp Tyr Lys Gly Glu 245 250 255 Glu Lys Asp Arg Ala Pro Gly Glu Lys Gly Glu Glu Lys Glu Glu Asp 260 265 270 Glu Asp Tyr Pro Ser Glu Asp Ile Glu Gly Glu Asp Gln Glu Asp Lys 275 280 285 Glu Glu Asp Glu Glu Glu Gln Ala Leu Trp Phe Asn Gly Thr Thr Asp 290 295 300 Asn Trp Asp Gln Gly Trp Leu Ala Pro Gly Asp Trp Val Phe Lys Asp 305 310 315 320 Ser Val Ser Tyr Asp Tyr Glu Pro Gln Lys Glu Trp Ser Pro Trp Ser 325 330 335 Pro Cys Ser Gly Asn Cys Ser Thr Gly Lys Gln Gln Arg Thr Arg Pro 340 345 350 Cys Gly Tyr Gly Cys Thr Ala Thr Glu Thr Arg Thr Cys Asp Leu Pro 355 360 365 Ser Cys Pro Gly Thr Glu Asp Lys Asp Thr Leu Gly Leu Pro Ser Glu 370 375 380 Glu Trp Lys Leu Leu Ala Arg Asn Ala Thr Asp Met His Asp Gln Asp 385 390 395 400 Val Asp Ser Cys Glu Lys Trp Leu Asn Cys Lys Ser Asp Phe Leu Ile 405 410 415 Lys Tyr Leu Ser Gln Met Leu Arg Asp Leu Pro Ser Cys Pro Cys Ala 420 425 430 Tyr Pro Leu Glu Ala Met Asp Ser Pro Val Ser Leu Gln Asp Glu His 435 440 445 Gln Gly Arg Ser Phe Arg Trp Arg Asp Ala Ser Gly Pro Arg Glu Arg 450 455 460 Leu Asp Ile Tyr Gln Pro Thr Ala Arg Phe Cys Leu Arg Ser Met Leu 465 470 475 480 Ser Gly Glu Ser Ser Thr Leu Ala Ala Gln His Cys Cys Tyr Asp Glu 485 490 495 Asp Ser Arg Leu Leu Thr Arg Gly Lys Gly Ala Gly Met Pro Asn Leu 500 505 510 Ile Ser Thr Asp Phe Ser Pro Lys Leu His Phe Lys Phe Asp Thr Thr 515 520 525 Pro Trp Ile Leu Cys Lys Gly Asp Trp Ser Arg Leu His Ala Val Leu 530 535 540 Pro Pro Asn Asn Gly Arg Ala Cys Thr Asp Asn Pro Leu Glu Glu Glu 545 550 555 560 Tyr Leu Ala Gln Leu Gln Glu Ala Lys Glu Tyr 565 570 <210> 155 <211> 1361 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (169)..(822) <400> 155 tggcggtggc gcggtagcgc gcgatgcagc acaggctaga ggctgcgcaa gcgcggggcc 60 cgcccctggg accctccggg ccgggcggtt tggcccctta gcgcccgggc gtcggggcgg 120 taaaaggccg gcagaaggga ggcacttgag gacccaagtt tcttcacc atg ggg atg 177 Met Gly Met 1 tgg tcc att ggt gca gga gcc ctg ggg gct gct gcc ttg gca ttg ctg 225 Trp Ser Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu Ala Leu Leu 5 10 15 ctt gcc aac aca gac gtg ttt ctg tcc aag ccc cag aaa gcg gcc ctg 273 Leu Ala Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys Ala Ala Leu 20 25 30 35 gag tac ctg gag gat ata gac ctg aaa aca ctg gag aag gaa cca agg 321 Glu Tyr Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys Glu Pro Arg 40 45 50 act ttc aaa gca aag gag cta tgg gaa aaa aat gga gct gtg att atg 369 Thr Phe Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala Val Ile Met 55 60 65 gcc gtg cgg agg cca ggc tgt ttc ctc tgt cga gag gaa gct gcg gat 417 Ala Val Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu Ala Ala Asp 70 75 80 ctg tcc tcc ctg aaa agc atg ttg gac cag ctg ggc gtc ccc ctc tat 465 Leu Ser Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val Pro Leu Tyr 85 90 95 gca gtg gta aag gag cac atc agg act gaa gtg aag gat ttc cag cct 513 Ala Val Val Lys Glu His Ile Arg Thr Glu Val Lys Asp Phe Gln Pro 100 105 110 115 tat ttc aaa gga gaa atc ttc ctg gat gaa aag aaa aag ttc tat ggt 561 Tyr Phe Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys Phe Tyr Gly 120 125 130 cca caa agg cgg aag atg atg ttt atg gga ttt atc cgt ctg gga gtg 609 Pro Gln Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg Leu Gly Val 135 140 145 tgg tac aac ttc ttc cga gcc tgg aac gga ggc ttc tct gga aac ctg 657 Trp Tyr Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser Gly Asn Leu 150 155 160 gaa gga gaa ggc ttc atc ctt ggg gga gtt ttc gtg gtg gga tca gga 705 Glu Gly Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val Gly Ser Gly 165 170 175 aag cag ggc att ctt ctt gag cac cga gaa aaa gaa ttt gga gac aga 753 Lys Gln Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe Gly Asp Arg 180 185 190 195 gta aac cta ctt tct gtt ctg gaa gct gct aag atg atc aaa cca cag 801 Val Asn Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile Lys Pro Gln 200 205 210 act ttg gcc tca gag aaa aaa tgattgtgtg aaactgccca gctcagggat 852 Thr Leu Ala Ser Glu Lys Lys 215 aaccagggac attcacctgt gttcatggga tgtattgttt ccactcgtgt ccctaaggag 912 tgagaaaccc atttatactc tactctcagt atggattatt aatgtatttt aatattctgt 972 ttaggcccac taaggcaaaa tagccccaaa acaagactga caaaaatctg aaaaactaat 1032 gaggattatt aagctaaaac ctgggaaata ggaggcttaa aattgactgc caggctgggt 1092 gcagtggctc acacctgtaa tcccagcact ttgggaggcc aaggtgagca agtcacttga 1152 ggtcgggagt tcgagaccag cctgagcaac atggcgaaac cccgtctcta ctaaaaatac 1212 aaaaatcacc cgggtgtggt ggcaggcacc tgtagtccca gctacccggg aggctgaggc 1272 aggagaatca cttgaacctg ggaggtggag gttgcggtga gctgagatca caccactgta 1332 ttccagcctg ggtgactgag actctaact 1361 <210> 156 <211> 218 <212> PRT <213> Homo sapiens <400> 156 Met Gly Met Trp Ser Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu 1 5 10 15 Ala Leu Leu Leu Ala Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys 20 25 30 Ala Ala Leu Glu Tyr Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys 35 40 45 Glu Pro Arg Thr Phe Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala 50 55 60 Val Ile Met Ala Val Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu 65 70 75 80 Ala Ala Asp Leu Ser Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val 85 90 95 Pro Leu Tyr Ala Val Val Lys Glu His Ile Arg Thr Glu Val Lys Asp 100 105 110 Phe Gln Pro Tyr Phe Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys 115 120 125 Phe Tyr Gly Pro Gln Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg 130 135 140 Leu Gly Val Trp Tyr Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser 145 150 155 160 Gly Asn Leu Glu Gly Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val 165 170 175 Gly Ser Gly Lys Gln Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe 180 185 190 Gly Asp Arg Val Asn Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile 195 200 205 Lys Pro Gln Thr Leu Ala Ser Glu Lys Lys 210 215 <210> 157 <211> 1976 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (13)..(387) <400> 157 atctttattg aa atg tat ttc atc ttc acg tct ttc tgg gca tat aag atc 51 Met Tyr Phe Ile Phe Thr Ser Phe Trp Ala Tyr Lys Ile 1 5 10 tat tat gtc tat ggc ttc atg atg ctg gtg ctg gtt atc ctg tgc att 99 Tyr Tyr Val Tyr Gly Phe Met Met Leu Val Leu Val Ile Leu Cys Ile 15 20 25 gtg act gtc tgt gtg act att gtg tgc aca tat ttt cta cta aat gca 147 Val Thr Val Cys Val Thr Ile Val Cys Thr Tyr Phe Leu Leu Asn Ala 30 35 40 45 gaa gat tac agg tgg caa tgg aca agt ttt ctc tct gct gca tca act 195 Glu Asp Tyr Arg Trp Gln Trp Thr Ser Phe Leu Ser Ala Ala Ser Thr 50 55 60 gca atc tat gtt tac atg tat tcc ttt tac tac tat ttt ttc aaa aca 243 Ala Ile Tyr Val Tyr Met Tyr Ser Phe Tyr Tyr Tyr Phe Phe Lys Thr 65 70 75 aag atg tat ggc tta ttt caa aca tca ttt tac ttt gga tat atg gcg 291 Lys Met Tyr Gly Leu Phe Gln Thr Ser Phe Tyr Phe Gly Tyr Met Ala 80 85 90 gta ttt agc aca gcc ttg ggg ata atg tgt gga gcg att ggt tac atg 339 Val Phe Ser Thr Ala Leu Gly Ile Met Cys Gly Ala Ile Gly Tyr Met 95 100 105 gga aca agt gcc ttt gtc cga aaa atc tat act aat gtg aaa att gac 387 Gly Thr Ser Ala Phe Val Arg Lys Ile Tyr Thr Asn Val Lys Ile Asp 110 115 120 125 tagagaccca agaaaacctg gaactttgga tcaatttctt tttcataggg gtggaacttg 447 cacagcaaaa acaaacaaac gcaagaagag atttgggctt taacacactg ggtactttgt 507 gggtctctct ttcgtcggtg gcttaaagta acatctattt ccattgatcc taggttcttc 567 ctgactgctt tctccaactg ttcacagcaa atgcttggat tttatgcagt aggcattact 627 acagtacatg gctaatcttc ccaaaaacta gctcattaaa gatgaaatag accagctctc 687 ttcagtgaag aggacaaata gtttatttaa agcatttgtt ccaataagat aaatagaggg 747 aaacttggat gctaaaatta catgaatagg aatcttcctg gcacttagtg tttctatgtt 807 attgaaaaat gatgttccag aaagattact tttttcctct tatttttact gccattgtcg 867 acctattgtg ggacattttt atatattgaa tctgggttct tttttgactt tttttttccc 927 aatccaacag catccttttt tttaaaagag agaattagaa aatattaaat cctgcatgta 987 atatatctgc tgtcatctta gttggaccaa cttcccattt atttatctta aaactataca 1047 gttacatctt aattccatcc aaagaagata cagtttgaag acagaagtgt actctctaca 1107 atgcaattta ctgtacagtt agaaagcaaa gtgttaaatg gagaagatac ttgtttttat 1167 taaacatttt gagatttaga taaactacat tttaactgaa tgtctaaagt gattatcttt 1227 tttcccccca agttagtctt aaatcttttg ggtttgaatg aaggttttac ataagaaatt 1287 attaaaaaca aggggggtgg gtaataaatg tatataacat taaataatgt aacgtaggtg 1347 tagattccca aatgcatttg gatgtacaga tcgactacag agtacttttt tcttatgatg 1407 attggtgtag aaatgtgtga tttgggtggg cttttacatc ttgcctacca ttgcatgaaa 1467 cattggggtt tcttcaaaat gtgtgtgtca tacttctttt gggagggggg ttgttttctt 1527 ctgtttattt tctgagactc ctacaggagc caaatttgta atttagagac acttaatttt 1587 gttaatcctg tctgggacac ttaagtaaca tctaaagcat tattgcttta gaatgttcaa 1647 ataaaatttc ctgaccaaat tgttttgtgg aaatagatgt gtttgcaatt tgaagatatc 1707 tttctgtcca gaaggcaaaa ttaccgaatg ccatttttaa aagtatgcta taaactatgc 1767 tactctcata caggggaccc atattttaaa atctccagag ttgcttacat ctagattatc 1827 cagcacaatc ataaagtgaa tgacaaaccc tttgaatgaa attgtggcac aaaatctgtt 1887 caggttggtg taccgtgtaa agtggggatg gggtaaaagt ggttaacgta ctgttggatc 1947 aacaaataaa ggttacagtt ttgtaagag 1976 <210> 158 <211> 125 <212> PRT <213> Homo sapiens <400> 158 Met Tyr Phe Ile Phe Thr Ser Phe Trp Ala Tyr Lys Ile Tyr Tyr Val 1 5 10 15 Tyr Gly Phe Met Met Leu Val Leu Val Ile Leu Cys Ile Val Thr Val 20 25 30 Cys Val Thr Ile Val Cys Thr Tyr Phe Leu Leu Asn Ala Glu Asp Tyr 35 40 45 Arg Trp Gln Trp Thr Ser Phe Leu Ser Ala Ala Ser Thr Ala Ile Tyr 50 55 60 Val Tyr Met Tyr Ser Phe Tyr Tyr Tyr Phe Phe Lys Thr Lys Met Tyr 65 70 75 80 Gly Leu Phe Gln Thr Ser Phe Tyr Phe Gly Tyr Met Ala Val Phe Ser 85 90 95 Thr Ala Leu Gly Ile Met Cys Gly Ala Ile Gly Tyr Met Gly Thr Ser 100 105 110 Ala Phe Val Arg Lys Ile Tyr Thr Asn Val Lys Ile Asp 115 120 125 <210> 159 <211> 2067 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (208)..(948) <400> 159 tctcttcggc ttccgtagag gaagtggcgc ggaccttcat ttggggtttc ggttcccccc 60 cttccccttc cccggggtct gggggtgaca ttgcaccgcg cccctcgtgg ggtcgcgttg 120 ccaccccacg cggactcccc agctggcgcg cccctcccat ttgcctgtcc tggtcaggcc 180 cccacccacc ttcccacctg accagcc atg ggg gct gcg gtg ttt tgc ggc tgc 234 Met Gly Ala Ala Val Phe Cys Gly Cys 1 5 act ttc gtc gcg ttc ggc ccg gcc ttc gcg ctt ttc ttg atc act gtg 282 Thr Phe Val Ala Phe Gly Pro Ala Phe Ala Leu Phe Leu Ile Thr Val 10 15 20 25 gct ggg gac ccg ctt cgc gtt atc atc ctg gtc gca ggg gca ttt ttc 330 Ala Gly Asp Pro Leu Arg Val Ile Ile Leu Val Ala Gly Ala Phe Phe 30 35 40 tgg ctg gtc tcc ctg ctc ctg gcc tct gtg gtc tgg ttc atc ttg gtc 378 Trp Leu Val Ser Leu Leu Leu Ala Ser Val Val Trp Phe Ile Leu Val 45 50 55 cat gtg acc gac cgg tca gat gcc cgg ctc cag tac ggc ctc ctg att 426 His Val Thr Asp Arg Ser Asp Ala Arg Leu Gln Tyr Gly Leu Leu Ile 60 65 70 ttt ggt gct gct gtc tct gtc ctt cta cag gag gtg ttc cgc ttt gcc 474 Phe Gly Ala Ala Val Ser Val Leu Leu Gln Glu Val Phe Arg Phe Ala 75 80 85 tac tac aag ctg ctt aag aag gca gat gag ggg tta gca tcg ctg agt 522 Tyr Tyr Lys Leu Leu Lys Lys Ala Asp Glu Gly Leu Ala Ser Leu Ser 90 95 100 105 gag gac gga aga tca ccc atc tcc atc cgc cag atg gcc tat gtt tct 570 Glu Asp Gly Arg Ser Pro Ile Ser Ile Arg Gln Met Ala Tyr Val Ser 110 115 120 ggt ctc tcc ttc ggt atc atc agt ggt gtc ttc tct gtt atc agt att 618 Gly Leu Ser Phe Gly Ile Ile Ser Gly Val Phe Ser Val Ile Ser Ile 125 130 135 ttg gct gat gca ctt ggg cca ggt gtg gtt ggg atc cat gga gac tca 666 Leu Ala Asp Ala Leu Gly Pro Gly Val Val Gly Ile His Gly Asp Ser 140 145 150 ccc tat tac ttc ctg act tca gcc ttt ctg aca gca gcc att atc ctg 714 Pro Tyr Tyr Phe Leu Thr Ser Ala Phe Leu Thr Ala Ala Ile Ile Leu 155 160 165 ctc cat acc ttt tgg gga gtt gtg ttc ttt gat gcc tgt gag agg aga 762 Leu His Thr Phe Trp Gly Val Val Phe Phe Asp Ala Cys Glu Arg Arg 170 175 180 185 cgg tac tgg gct ttg ggc ctg gtg gtt ggg agt cac cta ctg aca tcg 810 Arg Tyr Trp Ala Leu Gly Leu Val Val Gly Ser His Leu Leu Thr Ser 190 195 200 gga ctg aca ttc ctg aac ccc tgg tat gag gcc agc ctg ctg ccc atc 858 Gly Leu Thr Phe Leu Asn Pro Trp Tyr Glu Ala Ser Leu Leu Pro Ile 205 210 215 tat gca gtc act gtt tcc atg ggg ctc tgg gcc ttc atc aca gct gga 906 Tyr Ala Val Thr Val Ser Met Gly Leu Trp Ala Phe Ile Thr Ala Gly 220 225 230 ggg tcc ctc cga agt att cag cgc agc ctc ttg tgt aag gac 948 Gly Ser Leu Arg Ser Ile Gln Arg Ser Leu Leu Cys Lys Asp 235 240 245 tgactacctg gactgatcgc ctgacagatc ccacctgcct gtccactgcc catgactgag 1008 cccagcccca gcccgggtcc attgccctca ttctctgtct ccttctcgtc ggtctacccc 1068 gctacctcca gggttttgct ttgtcctttt gtgaccgtta gtctctaagc tttaccagga 1128 gcagcctggg ttcagccagt cagtgactgg tgggtttgaa tctgcactta tccccaccac 1188 ctggggaccc ccttgttgtg tccaggactc cccctgtgtc agtgctctgc tctcaccctg 1248 cccaagactc acctcccttc ccctctgcag gccgacggca ggaggacagt cgggtgatgg 1308 tgtattctgc cctgcgcatc ccacccgagg actgagggaa cctagggggg acccctgggc 1368 ctggggtgcc ctcctgatgt cctcgccctg tatttctcca tctccagttc tggacagtgc 1428 aggttgccaa gaaaagggac ctagtttagc cattgccctg gagatgaaat taatggaggc 1488 tcaaggatag atgagctctg agtttctcag tactccctca agactggaca tcttggtctt 1548 tttctcaggc ctgaggggga accatttttg gtgtgataaa taccctaaac tgcctttttt 1608 tcttttttga ggtgggggga gggaggaggt atattggaac tcttctaacc tccttgggct 1668 atattttctc tcctcgagtt gctcctcatg gctgggctca tttcggtccc tttctccttg 1728 gtcccagacc ttgggggaaa ggaaggaagt gcatgtttgg gaactggcat tactggaact 1788 aatggtttta acctccttaa ccaccagcat ccctcctctc cccaaggtga agtggagggt 1848 gctgtggtga gctggccact ccagagctgc agtgccactg gaggagtcag actaccatga 1908 catcgtaggg aaggagggga gatttttttg tagtttttaa ttgggatgtg ggaggggcgg 1968 ggaggttttc tataaactgt atcattttct gctgagggtg gagtgtccca tccttttaat 2028 caaggtgatt gtgattttga ctaataaaaa agaatttgt 2067 <210> 160 <211> 247 <212> PRT <213> Homo sapiens <400> 160 Met Gly Ala Ala Val Phe Cys Gly Cys Thr Phe Val Ala Phe Gly Pro 1 5 10 15 Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 20 25 30 Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 35 40 45 Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 50 55 60 Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 65 70 75 80 Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 85 90 95 Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 100 105 110 Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 115 120 125 Ser Gly Val Phe Ser Val Ile Ser Ile Leu Ala Asp Ala Leu Gly Pro 130 135 140 Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 145 150 155 160 Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 165 170 175 Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 180 185 190 Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 195 200 205 Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 210 215 220 Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 225 230 235 240 Arg Ser Leu Leu Cys Lys Asp 245 <210> 161 <211> 2807 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (264)..(1301) <400> 161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 60 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 180 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240 nnnnnnnnnn nnnnnnnnnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 293 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1 5 10 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 341 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 15 20 25 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 389 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 30 35 40 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 437 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 45 50 55 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 485 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 60 65 70 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 533 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 75 80 85 90 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 581 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 95 100 105 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 629 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 110 115 120 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 677 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 125 130 135 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 725 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 140 145 150 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 773 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 155 160 165 170 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 821 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 175 180 185 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 869 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 190 195 200 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 917 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 205 210 215 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 965 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 220 225 230 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1013 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 235 240 245 250 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1061 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 255 260 265 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1109 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 270 275 280 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1157 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 285 290 295 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1205 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 300 305 310 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1253 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 315 320 325 330 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1301 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 335 340 345 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2801 nnnnnn 2807 <210> 162 <211> 346 <212> PRT <213> Homo sapiens <400> 162 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1 5 10 15 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 20 25 30 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 35 40 45 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 50 55 60 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 65 70 75 80 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 85 90 95 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 100 105 110 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 115 120 125 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 130 135 140 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 145 150 155 160 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 165 170 175 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 180 185 190 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 195 200 205 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 210 215 220 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 225 230 235 240 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 245 250 255 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 260 265 270 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 275 280 285 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 290 295 300 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 305 310 315 320 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 325 330 335 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 340 345 <210> 163 <211> 1964 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (170)..(1729) <400> 163 gcgctgctgt ggcggccgct gtagcagcgg cggtccagtc gtagcccggc cgcccgcgcc 60 tgtccggtcc ggtccggcca cggaggcagc gcagcggcgg gactccgagc ctaccccgcc 120 gagtgagctg cgccgcaccg tgccgtccca cccggcaccc accagtccg atg ggg ccg 178 Met Gly Pro 1 cag cgg cgg ctg tcc cct gcc ggg gcc gcc cta ctc tgg ggc ttc ctg 226 Gln Arg Arg Leu Ser Pro Ala Gly Ala Ala Leu Leu Trp Gly Phe Leu 5 10 15 ctc cag ctg aca gcc gct cag gaa gca atc ttg cat gcg tct gga aat 274 Leu Gln Leu Thr Ala Ala Gln Glu Ala Ile Leu His Ala Ser Gly Asn 20 25 30 35 ggc aca acc aag gac tac tgc atg ctt tat aac cct tat tgg aca gct 322 Gly Thr Thr Lys Asp Tyr Cys Met Leu Tyr Asn Pro Tyr Trp Thr Ala 40 45 50 ctt cca agt acc cta gaa aat gca act tcc att agt ttg atg aat ctg 370 Leu Pro Ser Thr Leu Glu Asn Ala Thr Ser Ile Ser Leu Met Asn Leu 55 60 65 act tcc aca cca cta tgc aac ctt tct gat att cct cct gtt ggc ata 418 Thr Ser Thr Pro Leu Cys Asn Leu Ser Asp Ile Pro Pro Val Gly Ile 70 75 80 aag agc aaa gca gtt gtg gtt cca tgg gga agc tgc cat ttt ctt gaa 466 Lys Ser Lys Ala Val Val Val Pro Trp Gly Ser Cys His Phe Leu Glu 85 90 95 aaa gcc aga att gca cag aaa gga ggt gct gaa gca atg tta gtt gtc 514 Lys Ala Arg Ile Ala Gln Lys Gly Gly Ala Glu Ala Met Leu Val Val 100 105 110 115 aat aac agt gtc cta ttt cct ccc tca ggt aac aga tct gaa ttt cct 562 Asn Asn Ser Val Leu Phe Pro Pro Ser Gly Asn Arg Ser Glu Phe Pro 120 125 130 gat gtg aaa ata ctg att gca ttt ata agc tac aaa gac ttt aga gat 610 Asp Val Lys Ile Leu Ile Ala Phe Ile Ser Tyr Lys Asp Phe Arg Asp 135 140 145 atg aac cag act cta gga gat aac att act gtg aaa atg tat tct cca 658 Met Asn Gln Thr Leu Gly Asp Asn Ile Thr Val Lys Met Tyr Ser Pro 150 155 160 tcg tgg cct aac ttt gat tat act atg gtg gtt att ttt gta att gcg 706 Ser Trp Pro Asn Phe Asp Tyr Thr Met Val Val Ile Phe Val Ile Ala 165 170 175 gtg ttc act gtg gca tta ggt gga tac tgg agt gga cta gtt gaa ttg 754 Val Phe Thr Val Ala Leu Gly Gly Tyr Trp Ser Gly Leu Val Glu Leu 180 185 190 195 gaa aac ttg aaa gca gtg aca act gaa gat aga gaa atg agg aaa aag 802 Glu Asn Leu Lys Ala Val Thr Thr Glu Asp Arg Glu Met Arg Lys Lys 200 205 210 aag gaa gaa tat tta act ttt agt cct ctt aca gtt gta ata ttt gtg 850 Lys Glu Glu Tyr Leu Thr Phe Ser Pro Leu Thr Val Val Ile Phe Val 215 220 225 gtc atc tgc tgt gtt atg atg gtc tta ctt tat ttc ttc tac aaa tgg 898 Val Ile Cys Cys Val Met Met Val Leu Leu Tyr Phe Phe Tyr Lys Trp 230 235 240 ttg gtt tat gtt atg ata gca att ttc tgc ata gca tca gca atg agt 946 Leu Val Tyr Val Met Ile Ala Ile Phe Cys Ile Ala Ser Ala Met Ser 245 250 255 ctg tac aac tgt ctt gct gca cta att cat aag aca cca tat gga caa 994 Leu Tyr Asn Cys Leu Ala Ala Leu Ile His Lys Thr Pro Tyr Gly Gln 260 265 270 275 tgc acg att gca tgt cgt ggc aaa aac atg gaa gtg aga ctt att ttt 1042 Cys Thr Ile Ala Cys Arg Gly Lys Asn Met Glu Val Arg Leu Ile Phe 280 285 290 ctc tct gga ctg tgc ata gca gta gct gtt gtt tgg gct gtg ttt cga 1090 Leu Ser Gly Leu Cys Ile Ala Val Ala Val Val Trp Ala Val Phe Arg 295 300 305 aat gaa gac agg tgg gct tgg att tta cag gat atc ttg ggg att gct 1138 Asn Glu Asp Arg Trp Ala Trp Ile Leu Gln Asp Ile Leu Gly Ile Ala 310 315 320 ttc tgt ctg aat tta att aaa aca ctg aag ttg ccc aac ttc aag tca 1186 Phe Cys Leu Asn Leu Ile Lys Thr Leu Lys Leu Pro Asn Phe Lys Ser 325 330 335 tgt gtg ata ctt cta ggc ctt ctc ctc ctc tat gat gta ttt ttt gtt 1234 Cys Val Ile Leu Leu Gly Leu Leu Leu Leu Tyr Asp Val Phe Phe Val 340 345 350 355 ttc ata aca cca ttc atc aca aag aat ggt gag agt atc atg gtt gaa 1282 Phe Ile Thr Pro Phe Ile Thr Lys Asn Gly Glu Ser Ile Met Val Glu 360 365 370 ctc gca gct gga cct ttt gga aat aat gaa aag ttg cca gta gtc atc 1330 Leu Ala Ala Gly Pro Phe Gly Asn Asn Glu Lys Leu Pro Val Val Ile 375 380 385 aga gta cca aaa ctg atc tat ttc tca gta atg agt gtg tgc ctc atg 1378 Arg Val Pro Lys Leu Ile Tyr Phe Ser Val Met Ser Val Cys Leu Met 390 395 400 cct gtt tta ata ttg ggt ttt gga gac att att gta cca ggc ctg ttg 1426 Pro Val Leu Ile Leu Gly Phe Gly Asp Ile Ile Val Pro Gly Leu Leu 405 410 415 att gca tac tgt aga aga ttt gat gtt cag act ggt tct tct tac ata 1474 Ile Ala Tyr Cys Arg Arg Phe Asp Val Gln Thr Gly Ser Ser Tyr Ile 420 425 430 435 tac tat gtt tcg tct aca gtt gcc tat gct ttt ggc atg ata ctt aca 1522 Tyr Tyr Val Ser Ser Thr Val Ala Tyr Ala Phe Gly Met Ile Leu Thr 440 445 450 ttt gtt gtt ctg gtg ctg atg aaa aag ggg caa cct gct ctc ctc tat 1570 Phe Val Val Leu Val Leu Met Lys Lys Gly Gln Pro Ala Leu Leu Tyr 455 460 465 tta gta cct tgc aca ctt att act gcc tca gtt gtt gcc tgg aga cgt 1618 Leu Val Pro Cys Thr Leu Ile Thr Ala Ser Val Val Ala Trp Arg Arg 470 475 480 aag gaa atg aaa aag ttc tgg aaa ggt aac agc tat cag atg atg gac 1666 Lys Glu Met Lys Lys Phe Trp Lys Gly Asn Ser Tyr Gln Met Met Asp 485 490 495 cat ttg gat tgt gca aca aat gaa gaa aac cct gtg ata tct ggt gaa 1714 His Leu Asp Cys Ala Thr Asn Glu Glu Asn Pro Val Ile Ser Gly Glu 500 505 510 515 cag att gtc cag caa taatattatg tggaactgct ataatgtgtc attgattttc 1769 Gln Ile Val Gln Gln 520 tacaaataga cttcgacttt ttatattgac ttttgaattg acaatctgaa agagtcttca 1829 atgatatgct tgcaaaaata tatttttatg agctggtact gacagttaca tcataaataa 1889 ctaaaacgct ttgcttttaa tgttaaagtt gtgccttcac attaaataaa acatatggtc 1949 tgtgtagttt ccgag 1964 <210> 164 <211> 520 <212> PRT <213> Homo sapiens <400> 164 Met Gly Pro Gln Arg Arg Leu Ser Pro Ala Gly Ala Ala Leu Leu Trp 1 5 10 15 Gly Phe Leu Leu Gln Leu Thr Ala Ala Gln Glu Ala Ile Leu His Ala 20 25 30 Ser Gly Asn Gly Thr Thr Lys Asp Tyr Cys Met Leu Tyr Asn Pro Tyr 35 40 45 Trp Thr Ala Leu Pro Ser Thr Leu Glu Asn Ala Thr Ser Ile Ser Leu 50 55 60 Met Asn Leu Thr Ser Thr Pro Leu Cys Asn Leu Ser Asp Ile Pro Pro 65 70 75 80 Val Gly Ile Lys Ser Lys Ala Val Val Val Pro Trp Gly Ser Cys His 85 90 95 Phe Leu Glu Lys Ala Arg Ile Ala Gln Lys Gly Gly Ala Glu Ala Met 100 105 110 Leu Val Val Asn Asn Ser Val Leu Phe Pro Pro Ser Gly Asn Arg Ser 115 120 125 Glu Phe Pro Asp Val Lys Ile Leu Ile Ala Phe Ile Ser Tyr Lys Asp 130 135 140 Phe Arg Asp Met Asn Gln Thr Leu Gly Asp Asn Ile Thr Val Lys Met 145 150 155 160 Tyr Ser Pro Ser Trp Pro Asn Phe Asp Tyr Thr Met Val Val Ile Phe 165 170 175 Val Ile Ala Val Phe Thr Val Ala Leu Gly Gly Tyr Trp Ser Gly Leu 180 185 190 Val Glu Leu Glu Asn Leu Lys Ala Val Thr Thr Glu Asp Arg Glu Met 195 200 205 Arg Lys Lys Lys Glu Glu Tyr Leu Thr Phe Ser Pro Leu Thr Val Val 210 215 220 Ile Phe Val Val Ile Cys Cys Val Met Met Val Leu Leu Tyr Phe Phe 225 230 235 240 Tyr Lys Trp Leu Val Tyr Val Met Ile Ala Ile Phe Cys Ile Ala Ser 245 250 255 Ala Met Ser Leu Tyr Asn Cys Leu Ala Ala Leu Ile His Lys Thr Pro 260 265 270 Tyr Gly Gln Cys Thr Ile Ala Cys Arg Gly Lys Asn Met Glu Val Arg 275 280 285 Leu Ile Phe Leu Ser Gly Leu Cys Ile Ala Val Ala Val Val Trp Ala 290 295 300 Val Phe Arg Asn Glu Asp Arg Trp Ala Trp Ile Leu Gln Asp Ile Leu 305 310 315 320 Gly Ile Ala Phe Cys Leu Asn Leu Ile Lys Thr Leu Lys Leu Pro Asn 325 330 335 Phe Lys Ser Cys Val Ile Leu Leu Gly Leu Leu Leu Leu Tyr Asp Val 340 345 350 Phe Phe Val Phe Ile Thr Pro Phe Ile Thr Lys Asn Gly Glu Ser Ile 355 360 365 Met Val Glu Leu Ala Ala Gly Pro Phe Gly Asn Asn Glu Lys Leu Pro 370 375 380 Val Val Ile Arg Val Pro Lys Leu Ile Tyr Phe Ser Val Met Ser Val 385 390 395 400 Cys Leu Met Pro Val Leu Ile Leu Gly Phe Gly Asp Ile Ile Val Pro 405 410 415 Gly Leu Leu Ile Ala Tyr Cys Arg Arg Phe Asp Val Gln Thr Gly Ser 420 425 430 Ser Tyr Ile Tyr Tyr Val Ser Ser Thr Val Ala Tyr Ala Phe Gly Met 435 440 445 Ile Leu Thr Phe Val Val Leu Val Leu Met Lys Lys Gly Gln Pro Ala 450 455 460 Leu Leu Tyr Leu Val Pro Cys Thr Leu Ile Thr Ala Ser Val Val Ala 465 470 475 480 Trp Arg Arg Lys Glu Met Lys Lys Phe Trp Lys Gly Asn Ser Tyr Gln 485 490 495 Met Met Asp His Leu Asp Cys Ala Thr Asn Glu Glu Asn Pro Val Ile 500 505 510 Ser Gly Glu Gln Ile Val Gln Gln 515 520 <210> 165 <211> 1988 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (91)..(1386) <400> 165 gctcctggag gcggcggcgg gagcgcaggg ggcgcgcggc ccggggactc gcattccccg 60 gttccccctc caccccacgc ggcctggacc atg gac gcc aga tgg tgg gca gtg 114 Met Asp Ala Arg Trp Trp Ala Val 1 5 gtg gtg ctg gct gcg ttc ccc tcc cta ggg gca ggt ggg gag act ccc 162 Val Val Leu Ala Ala Phe Pro Ser Leu Gly Ala Gly Gly Glu Thr Pro 10 15 20 gaa gcc cct ccg gag tca tgg acc cag cta tgg ttc ttc cga ttt gtg 210 Glu Ala Pro Pro Glu Ser Trp Thr Gln Leu Trp Phe Phe Arg Phe Val 25 30 35 40 gtg aat gct gct ggc tat gcc agc ttt atg gta cct ggc tac ctc ctg 258 Val Asn Ala Ala Gly Tyr Ala Ser Phe Met Val Pro Gly Tyr Leu Leu 45 50 55 gtg cag tac ttc agg cgg aag aac tac ctg gag acc ggt agg ggc ctc 306 Val Gln Tyr Phe Arg Arg Lys Asn Tyr Leu Glu Thr Gly Arg Gly Leu 60 65 70 tgc ttt ccc ctg gtg aaa gct tgt gtg ttt ggc aat gag ccc aag gcc 354 Cys Phe Pro Leu Val Lys Ala Cys Val Phe Gly Asn Glu Pro Lys Ala 75 80 85 tct gat gag gtt ccc ctg gcg ccc cga aca gag gcg gca gag acc acc 402 Ser Asp Glu Val Pro Leu Ala Pro Arg Thr Glu Ala Ala Glu Thr Thr 90 95 100 ccg atg tgg cag gcc ctg aag ctg ctc ttc tgt gcc aca ggg ctc cag 450 Pro Met Trp Gln Ala Leu Lys Leu Leu Phe Cys Ala Thr Gly Leu Gln 105 110 115 120 gtg tct tat ctg act tgg ggt gtg ctg cag gaa aga gtg atg acc cgc 498 Val Ser Tyr Leu Thr Trp Gly Val Leu Gln Glu Arg Val Met Thr Arg 125 130 135 agc tat ggg gcc aca gcc aca tca ccg ggt gag cgc ttt acg gac tcg 546 Ser Tyr Gly Ala Thr Ala Thr Ser Pro Gly Glu Arg Phe Thr Asp Ser 140 145 150 cag ttc ctg gtg cta atg aac cga gtg ctg gca ctg att gtg gct ggc 594 Gln Phe Leu Val Leu Met Asn Arg Val Leu Ala Leu Ile Val Ala Gly 155 160 165 ctc tcc tgt gtt ctc tgc aag cag ccc cgg cat ggg gca ccc atg tac 642 Leu Ser Cys Val Leu Cys Lys Gln Pro Arg His Gly Ala Pro Met Tyr 170 175 180 cgg tac tcc ttt gcc agc ctg tcc aat gtg ctt agc agc tgg tgc caa 690 Arg Tyr Ser Phe Ala Ser Leu Ser Asn Val Leu Ser Ser Trp Cys Gln 185 190 195 200 tac gaa gct ctt aag ttc gtc agc ttc ccc acc cag gtg ctg gcc aag 738 Tyr Glu Ala Leu Lys Phe Val Ser Phe Pro Thr Gln Val Leu Ala Lys 205 210 215 gcc tct aag gtg atc cct gtc atg ctg atg gga aag ctt gtg tct cgg 786 Ala Ser Lys Val Ile Pro Val Met Leu Met Gly Lys Leu Val Ser Arg 220 225 230 cgc agc tac gaa cac tgg gag tac ctg aca gcc acc ctc atc tcc att 834 Arg Ser Tyr Glu His Trp Glu Tyr Leu Thr Ala Thr Leu Ile Ser Ile 235 240 245 ggg gtc agc atg ttt ctg cta tcc agc gga cca gag ccc cgc agc tcc 882 Gly Val Ser Met Phe Leu Leu Ser Ser Gly Pro Glu Pro Arg Ser Ser 250 255 260 cca gcc acc aca ctc tca ggc ctc atc tta ctg gca ggt tat att gct 930 Pro Ala Thr Thr Leu Ser Gly Leu Ile Leu Leu Ala Gly Tyr Ile Ala 265 270 275 280 ttt gac agc ttc acc tca aac tgg cag gat gcc ctg ttt gcc tat aag 978 Phe Asp Ser Phe Thr Ser Asn Trp Gln Asp Ala Leu Phe Ala Tyr Lys 285 290 295 atg tca tcg gtg cag atg atg ttt ggg gtc aat ttc ttc tcc tgc ctc 1026 Met Ser Ser Val Gln Met Met Phe Gly Val Asn Phe Phe Ser Cys Leu 300 305 310 ttc aca gtg ggc tca ctg cta gaa cag ggg gcc cta ctg gag gga acc 1074 Phe Thr Val Gly Ser Leu Leu Glu Gln Gly Ala Leu Leu Glu Gly Thr 315 320 325 cgc ttc atg ggg cga cac agt ggg ttt gct gcc cat gcc ctg cta ctc 1122 Arg Phe Met Gly Arg His Ser Gly Phe Ala Ala His Ala Leu Leu Leu 330 335 340 tcc atc tgc tcc gca tgt ggc cag ctc ttc atc ttt tac acc att ggg 1170 Ser Ile Cys Ser Ala Cys Gly Gln Leu Phe Ile Phe Tyr Thr Ile Gly 345 350 355 360 cag ttt ggg gct gcc gtc ttc acc atc atc atg acc ctc cgc cag gcc 1218 Gln Phe Gly Ala Ala Val Phe Thr Ile Ile Met Thr Leu Arg Gln Ala 365 370 375 ttt gcc atc ctt ctt tcc tgc ctt ctc tat ggc cac act gtc act gtg 1266 Phe Ala Ile Leu Leu Ser Cys Leu Leu Tyr Gly His Thr Val Thr Val 380 385 390 gtg gga ggg ctg ggg gtg gct gtg gtc ttt gct gcc ctc ctg ctc aga 1314 Val Gly Gly Leu Gly Val Ala Val Val Phe Ala Ala Leu Leu Leu Arg 395 400 405 gtc tac gcg cgg ggc cgt cta aag caa cgg gga aag aag gct gtg cct 1362 Val Tyr Ala Arg Gly Arg Leu Lys Gln Arg Gly Lys Lys Ala Val Pro 410 415 420 gtt gag tct cct gtg cag aag gtt tgagggtgga aagggcctga ggggtgaagt 1416 Val Glu Ser Pro Val Gln Lys Val 425 430 gaaataggac cctcccacca tccccttctg ctgtaacctc tgagggagct ggctgaaagg 1476 gcaaaatgca ggtgttttct cagtatcaca gaccagctct gcagcagggg attggggagc 1536 ccaggaggca gccttccctt ttgccttaag tcacccatct tccagtaagc agtttattct 1596 gagccccggg ggtagacagt cctcagtgag gggttttggg gagtttgggg tcaagagagc 1656 ataggtaggt tccagttact cttcccacaa gttcccttaa gtcttgccct agctgtgctc 1716 tgccaccttc cagactcact cccctctgca aatacctgca tttcttaccc tggtgagaaa 1776 agcacaagcg gtgtaggctc caatgctgct ttcccaggag ggtgaagatg gtgctgtgct 1836 gaggaaaggg gatgcagagc cctgcccagc accaccacct cctatgctcc tggatcccta 1896 ggctctgttc catgagcctg ttgcaggttt tggtacttta gaaatgtaac tttttgctct 1956 tataatttta ttttattaaa ttaaattact gc 1988 <210> 166 <211> 432 <212> PRT <213> Homo sapiens <400> 166 Met Asp Ala Arg Trp Trp Ala Val Val Val Leu Ala Ala Phe Pro Ser 1 5 10 15 Leu Gly Ala Gly Gly Glu Thr Pro Glu Ala Pro Pro Glu Ser Trp Thr 20 25 30 Gln Leu Trp Phe Phe Arg Phe Val Val Asn Ala Ala Gly Tyr Ala Ser 35 40 45 Phe Met Val Pro Gly Tyr Leu Leu Val Gln Tyr Phe Arg Arg Lys Asn 50 55 60 Tyr Leu Glu Thr Gly Arg Gly Leu Cys Phe Pro Leu Val Lys Ala Cys 65 70 75 80 Val Phe Gly Asn Glu Pro Lys Ala Ser Asp Glu Val Pro Leu Ala Pro 85 90 95 Arg Thr Glu Ala Ala Glu Thr Thr Pro Met Trp Gln Ala Leu Lys Leu 100 105 110 Leu Phe Cys Ala Thr Gly Leu Gln Val Ser Tyr Leu Thr Trp Gly Val 115 120 125 Leu Gln Glu Arg Val Met Thr Arg Ser Tyr Gly Ala Thr Ala Thr Ser 130 135 140 Pro Gly Glu Arg Phe Thr Asp Ser Gln Phe Leu Val Leu Met Asn Arg 145 150 155 160 Val Leu Ala Leu Ile Val Ala Gly Leu Ser Cys Val Leu Cys Lys Gln 165 170 175 Pro Arg His Gly Ala Pro Met Tyr Arg Tyr Ser Phe Ala Ser Leu Ser 180 185 190 Asn Val Leu Ser Ser Trp Cys Gln Tyr Glu Ala Leu Lys Phe Val Ser 195 200 205 Phe Pro Thr Gln Val Leu Ala Lys Ala Ser Lys Val Ile Pro Val Met 210 215 220 Leu Met Gly Lys Leu Val Ser Arg Arg Ser Tyr Glu His Trp Glu Tyr 225 230 235 240 Leu Thr Ala Thr Leu Ile Ser Ile Gly Val Ser Met Phe Leu Leu Ser 245 250 255 Ser Gly Pro Glu Pro Arg Ser Ser Pro Ala Thr Thr Leu Ser Gly Leu 260 265 270 Ile Leu Leu Ala Gly Tyr Ile Ala Phe Asp Ser Phe Thr Ser Asn Trp 275 280 285 Gln Asp Ala Leu Phe Ala Tyr Lys Met Ser Ser Val Gln Met Met Phe 290 295 300 Gly Val Asn Phe Phe Ser Cys Leu Phe Thr Val Gly Ser Leu Leu Glu 305 310 315 320 Gln Gly Ala Leu Leu Glu Gly Thr Arg Phe Met Gly Arg His Ser Gly 325 330 335 Phe Ala Ala His Ala Leu Leu Leu Ser Ile Cys Ser Ala Cys Gly Gln 340 345 350 Leu Phe Ile Phe Tyr Thr Ile Gly Gln Phe Gly Ala Ala Val Phe Thr 355 360 365 Ile Ile Met Thr Leu Arg Gln Ala Phe Ala Ile Leu Leu Ser Cys Leu 370 375 380 Leu Tyr Gly His Thr Val Thr Val Val Gly Gly Leu Gly Val Ala Val 385 390 395 400 Val Phe Ala Ala Leu Leu Leu Arg Val Tyr Ala Arg Gly Arg Leu Lys 405 410 415 Gln Arg Gly Lys Lys Ala Val Pro Val Glu Ser Pro Val Gln Lys Val 420 425 430 <210> 167 <211> 2259 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (20)..(670) <400> 167 gcaccccagc cagtttgcc atg ggg ggc gcc ttc tcc agc atg gcg gcc gct 52 Met Gly Gly Ala Phe Ser Ser Met Ala Ala Ala 1 5 10 ggc atg ggt ccc ctc ctg gcc acg gtt tct ggg gcc tcc acc ggt gtc 100 Gly Met Gly Pro Leu Leu Ala Thr Val Ser Gly Ala Ser Thr Gly Val 15 20 25 tcg ggc ctg gat tcc acg gcc atg gcc tct gcc gct gcg gcg cag gga 148 Ser Gly Leu Asp Ser Thr Ala Met Ala Ser Ala Ala Ala Ala Gln Gly 30 35 40 ctg tcc ggg gcg tcc gcg gcc acc ctg ccc ttc cac ctc cag cag cac 196 Leu Ser Gly Ala Ser Ala Ala Thr Leu Pro Phe His Leu Gln Gln His 45 50 55 gtc ctg gcc tct cag ggc ctg gcc atg tcc cct ttc gga agc ctg ttc 244 Val Leu Ala Ser Gln Gly Leu Ala Met Ser Pro Phe Gly Ser Leu Phe 60 65 70 75 cct tac ccc tac acg tac atg gcc gca gcg gcg gcc gcc tcc tct gcg 292 Pro Tyr Pro Tyr Thr Tyr Met Ala Ala Ala Ala Ala Ala Ser Ser Ala 80 85 90 gca gcc tcc agc tcg gtg cac cgc cac ccc ttc ctc aat ctg aac acc 340 Ala Ala Ser Ser Ser Val His Arg His Pro Phe Leu Asn Leu Asn Thr 95 100 105 atg cgc ccg cgg ctg cgc tac agc ccc tac tcc atc ccg gtg ccg gtc 388 Met Arg Pro Arg Leu Arg Tyr Ser Pro Tyr Ser Ile Pro Val Pro Val 110 115 120 ccg gac ggc agc agt ctg ctc acc acc gcc ctg ccc tcc atg gcg gcg 436 Pro Asp Gly Ser Ser Leu Leu Thr Thr Ala Leu Pro Ser Met Ala Ala 125 130 135 gcc gcg ggg ccc ctg gac ggc aaa gtc gcc gcc ctg gcc gcc agc ccg 484 Ala Ala Gly Pro Leu Asp Gly Lys Val Ala Ala Leu Ala Ala Ser Pro 140 145 150 155 gcc tcg gtg gca gtg gac tcg ggc tct gaa ctc aac agc cgc tcc tcc 532 Ala Ser Val Ala Val Asp Ser Gly Ser Glu Leu Asn Ser Arg Ser Ser 160 165 170 acg ctc tcc tcc agc tcc atg tcc ttg tcg ccc aaa ctc tgc gcg gag 580 Thr Leu Ser Ser Ser Ser Met Ser Leu Ser Pro Lys Leu Cys Ala Glu 175 180 185 aaa gag gcg gcc acc agc gaa ctg cag agc atc cag cgg ttg gtt agc 628 Lys Glu Ala Ala Thr Ser Glu Leu Gln Ser Ile Gln Arg Leu Val Ser 190 195 200 ggc ttg gaa gcc aag ccg gac agg tcc cgc agc gcg tcc ccg 670 Gly Leu Glu Ala Lys Pro Asp Arg Ser Arg Ser Ala Ser Pro 205 210 215 tagacccgtc ccagacacgt cttttcattc cagtccagtt caggctgccg tgcactttgt 730 cggatataaa ataaaccacg ggcccgccat ggcgttagcc cttccttttg cagttgcgtc 790 tgggaagggg ccccagactc cctcgagaga atgtgctaga gacagcccct gtcttcttgg 850 cgtggtttat atgtccggga tctggatcag attctggggg ctcagaaacg tcggttgcat 910 tgagctactg ggggtaggag ttccaacatt tatgtccaga gcaacttcca gcaaggctgg 970 tctgggtctc tgcccaccag gcggggaggt gttcaaagac atctccctca gtgcggattt 1030 atatatatat ttttccttca ctgtgtcaag tggaaacaaa aacaaaatct ttcaaaaaaa 1090 aaatcgggac aagtgaacac attaacatga ttctgtttgt gcagattaaa aactttatag 1150 ggacttgcat tatcggttct caataaatta ctgagcagct ttgtttgggg agggaagtcc 1210 ctaccatcct tgtttagtct atattaagaa aatctgtgtc tttttaatat tcttgtgatg 1270 ttttcagagc cgctgtaggt ctcttcttgc atgtccacag taatgtattt gtggttttta 1330 ttttgaacgc ttgcttttag agagaaaaca atatagcccc ctaccctttt cccaatcctt 1390 tgccctcaaa tcagtgaccc aagggaggga gggatttaaa gggaaggagt gggcaaaaca 1450 cataaaatga atttattata tctaagctct gtagcaggat tcatgtcgtt ctttgacagt 1510 tctttctctt tcctgtatat gcaataacaa ggttttaaaa aaataataaa gaagtgagac 1570 tattagacaa agtatttatg taattatttg ataactcttg taaataggtg gaatatgaat 1630 gcttggaaaa ttaaacttta atttattgac attgtacata gctctgtgta aatagaattg 1690 caactgtcag gttttgtgtt cttgttttcc tttagttggg tttatttcca ggtcacagaa 1750 ttgctgttaa cactagaaaa cacacttcct gcaccaacac caataccctt tcaaaagagt 1810 tgtctgcaac atttttgttt tcttttttaa tgtccaaaag tgggggaaag tgctatttcc 1870 tattttcacc aaaattgggg aaggagtgcc actttccagc tccacttcaa attccttaaa 1930 atataactga gattgctgtg gggagggagg agggcagagg ctgcggtttg actttttaat 1990 ttttcttttg ttatttgtat ttgctagtct ctgatttcct caaaacgaag tggaatttac 2050 tactgttgtc agtatcggtg ttttgaattg gtgcctgcct atagagatat attcacagtt 2110 caaaagtcag gtgctgagag atggtttaaa gacaaattca tgaaggtata ttttgtgtta 2170 tagttgttga tgagttcttt ggttttctgt atttttcccc ctctctttaa aacatcactg 2230 aaatttcaat aaatttttat tgaaatgtc 2259 <210> 168 <211> 217 <212> PRT <213> Homo sapiens <400> 168 Met Gly Gly Ala Phe Ser Ser Met Ala Ala Ala Gly Met Gly Pro Leu 1 5 10 15 Leu Ala Thr Val Ser Gly Ala Ser Thr Gly Val Ser Gly Leu Asp Ser 20 25 30 Thr Ala Met Ala Ser Ala Ala Ala Ala Gln Gly Leu Ser Gly Ala Ser 35 40 45 Ala Ala Thr Leu Pro Phe His Leu Gln Gln His Val Leu Ala Ser Gln 50 55 60 Gly Leu Ala Met Ser Pro Phe Gly Ser Leu Phe Pro Tyr Pro Tyr Thr 65 70 75 80 Tyr Met Ala Ala Ala Ala Ala Ala Ser Ser Ala Ala Ala Ser Ser Ser 85 90 95 Val His Arg His Pro Phe Leu Asn Leu Asn Thr Met Arg Pro Arg Leu 100 105 110 Arg Tyr Ser Pro Tyr Ser Ile Pro Val Pro Val Pro Asp Gly Ser Ser 115 120 125 Leu Leu Thr Thr Ala Leu Pro Ser Met Ala Ala Ala Ala Gly Pro Leu 130 135 140 Asp Gly Lys Val Ala Ala Leu Ala Ala Ser Pro Ala Ser Val Ala Val 145 150 155 160 Asp Ser Gly Ser Glu Leu Asn Ser Arg Ser Ser Thr Leu Ser Ser Ser 165 170 175 Ser Met Ser Leu Ser Pro Lys Leu Cys Ala Glu Lys Glu Ala Ala Thr 180 185 190 Ser Glu Leu Gln Ser Ile Gln Arg Leu Val Ser Gly Leu Glu Ala Lys 195 200 205 Pro Asp Arg Ser Arg Ser Ala Ser Pro 210 215 <210> 169 <211> 1688 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (56)..(1456) <400> 169 agcgctcccg aggccgcggg agcctgcaga gaggacagcc ggcctgcgcc gggac atg 58 Met 1 cgg ccc cag gag ctc ccc agg ctc gcg ttc ccg ttg ctg ctg ttg ctg 106 Arg Pro Gln Glu Leu Pro Arg Leu Ala Phe Pro Leu Leu Leu Leu Leu 5 10 15 ttg ctg ctg ctg ccg ccg ccg ccg tgc cct gcc cac agc gcc acg cgc 154 Leu Leu Leu Leu Pro Pro Pro Pro Cys Pro Ala His Ser Ala Thr Arg 20 25 30 ttc gac ccc acc tgg gag tcc ctg gac gcc cgc cag ctg ccc gcg tgg 202 Phe Asp Pro Thr Trp Glu Ser Leu Asp Ala Arg Gln Leu Pro Ala Trp 35 40 45 ttt gac cag gcc aag ttc ggc atc ttc atc cac tgg gga gtg ttt tcc 250 Phe Asp Gln Ala Lys Phe Gly Ile Phe Ile His Trp Gly Val Phe Ser 50 55 60 65 gtg ccc agc ttc ggt agc gag tgg ttc tgg tgg tat tgg caa aag gaa 298 Val Pro Ser Phe Gly Ser Glu Trp Phe Trp Trp Tyr Trp Gln Lys Glu 70 75 80 aag ata ccg aag tat gtg gaa ttt atg aaa gat aat tac cct cct agt 346 Lys Ile Pro Lys Tyr Val Glu Phe Met Lys Asp Asn Tyr Pro Pro Ser 85 90 95 ttc aaa tat gaa gat ttt gga cca cta ttt aca gca aaa ttt ttt aat 394 Phe Lys Tyr Glu Asp Phe Gly Pro Leu Phe Thr Ala Lys Phe Phe Asn 100 105 110 gcc aac cag tgg gca gat att ttt cag gcc tct ggt gcc aaa tac att 442 Ala Asn Gln Trp Ala Asp Ile Phe Gln Ala Ser Gly Ala Lys Tyr Ile 115 120 125 gtc tta act tcc aaa cat cat gaa ggc ttt acc ttg tgg ggg tca gaa 490 Val Leu Thr Ser Lys His His Glu Gly Phe Thr Leu Trp Gly Ser Glu 130 135 140 145 tat tcg tgg aac tgg aat gcc ata gat gag ggg ccc aag agg gac att 538 Tyr Ser Trp Asn Trp Asn Ala Ile Asp Glu Gly Pro Lys Arg Asp Ile 150 155 160 gtc aag gaa ctt gag gta gcc att agg aac aga act gac ctg cgt ttt 586 Val Lys Glu Leu Glu Val Ala Ile Arg Asn Arg Thr Asp Leu Arg Phe 165 170 175 gga ctg tac tat tcc ctt ttt gaa tgg ttt cat ccg ctc ttc ctt gag 634 Gly Leu Tyr Tyr Ser Leu Phe Glu Trp Phe His Pro Leu Phe Leu Glu 180 185 190 gat gaa tcc agt tca ttc cat aag cgg caa ttt cca gtt tct aag aca 682 Asp Glu Ser Ser Ser Phe His Lys Arg Gln Phe Pro Val Ser Lys Thr 195 200 205 ttg cca gag ctc tat gag tta gtg aac aac tat cag cct gag gtt ctg 730 Leu Pro Glu Leu Tyr Glu Leu Val Asn Asn Tyr Gln Pro Glu Val Leu 210 215 220 225 tgg tcg gat ggt gac gga gga gca ccg gat caa tac tgg aac agc aca 778 Trp Ser Asp Gly Asp Gly Gly Ala Pro Asp Gln Tyr Trp Asn Ser Thr 230 235 240 ggc ttc ttg gcc tgg tta tat aat gaa agc cca gtt cgg ggc aca gta 826 Gly Phe Leu Ala Trp Leu Tyr Asn Glu Ser Pro Val Arg Gly Thr Val 245 250 255 gtc acc aat gat cgt tgg gga gct ggt agc atc tgt aag cat ggt ggc 874 Val Thr Asn Asp Arg Trp Gly Ala Gly Ser Ile Cys Lys His Gly Gly 260 265 270 ttc tat acc tgc agt gat cgt tat aac cca gga cat ctt ttg cca cat 922 Phe Tyr Thr Cys Ser Asp Arg Tyr Asn Pro Gly His Leu Leu Pro His 275 280 285 aaa tgg gaa aac tgc atg aca ata gac aaa ctg tcc tgg ggc tat agg 970 Lys Trp Glu Asn Cys Met Thr Ile Asp Lys Leu Ser Trp Gly Tyr Arg 290 295 300 305 agg gaa gct gga atc tct gac tat ctt aca att gaa gaa ttg gtg aag 1018 Arg Glu Ala Gly Ile Ser Asp Tyr Leu Thr Ile Glu Glu Leu Val Lys 310 315 320 caa ctt gta gag aca gtt tca tgt gga gga aat ctt ttg atg aat att 1066 Gln Leu Val Glu Thr Val Ser Cys Gly Gly Asn Leu Leu Met Asn Ile 325 330 335 ggg ccc aca cta gat ggc acc att tct gta gtt ttt gag gag cga ctg 1114 Gly Pro Thr Leu Asp Gly Thr Ile Ser Val Val Phe Glu Glu Arg Leu 340 345 350 agg caa gtg ggg tcc tgg cta aaa gtc aat gga gaa gct att tat gaa 1162 Arg Gln Val Gly Ser Trp Leu Lys Val Asn Gly Glu Ala Ile Tyr Glu 355 360 365 acc tat acc tgg cga tcc cag aac gac act gtc acc cca gat gtg tgg 1210 Thr Tyr Thr Trp Arg Ser Gln Asn Asp Thr Val Thr Pro Asp Val Trp 370 375 380 385 tac aca tcc aag cct aaa gaa aaa tta gtc tat gcc att ttt cct aaa 1258 Tyr Thr Ser Lys Pro Lys Glu Lys Leu Val Tyr Ala Ile Phe Pro Lys 390 395 400 tgg ccc aca tca gga cag ctg ttc ctt ggc cat ccc aaa gct att ctg 1306 Trp Pro Thr Ser Gly Gln Leu Phe Leu Gly His Pro Lys Ala Ile Leu 405 410 415 ggg gca aca gag gtg aaa cta ctg ggc cat gga cag cca ctt aac tgg 1354 Gly Ala Thr Glu Val Lys Leu Leu Gly His Gly Gln Pro Leu Asn Trp 420 425 430 att tct ttg gag caa aat ggc att atg gta gaa ctg cca cag cta acc 1402 Ile Ser Leu Glu Gln Asn Gly Ile Met Val Glu Leu Pro Gln Leu Thr 435 440 445 att cat cag atg ccg tgt aaa tgg ggc tgg gct cta gcc cta act aat 1450 Ile His Gln Met Pro Cys Lys Trp Gly Trp Ala Leu Ala Leu Thr Asn 450 455 460 465 gtg atc taaagtgcag cagagtggct gatgctgcaa gttatgtcta aggctaggaa 1506 Val Ile ctatcaggtg tctataattg tagcacatgg agaaagcaaa tgtaaaactg gataagaaaa 1566 ttattttggc agttcagccc tttccctttt tcccactaaa ttttttctta aattacccat 1626 gtaaccattt taactctcca gtgcactttg ccattaaagt ctcttcacat tgatttgtct 1686 cc 1688 <210> 170 <211> 467 <212> PRT <213> Homo sapiens <400> 170 Met Arg Pro Gln Glu Leu Pro Arg Leu Ala Phe Pro Leu Leu Leu Leu 1 5 10 15 Leu Leu Leu Leu Leu Pro Pro Pro Pro Cys Pro Ala His Ser Ala Thr 20 25 30 Arg Phe Asp Pro Thr Trp Glu Ser Leu Asp Ala Arg Gln Leu Pro Ala 35 40 45 Trp Phe Asp Gln Ala Lys Phe Gly Ile Phe Ile His Trp Gly Val Phe 50 55 60 Ser Val Pro Ser Phe Gly Ser Glu Trp Phe Trp Trp Tyr Trp Gln Lys 65 70 75 80 Glu Lys Ile Pro Lys Tyr Val Glu Phe Met Lys Asp Asn Tyr Pro Pro 85 90 95 Ser Phe Lys Tyr Glu Asp Phe Gly Pro Leu Phe Thr Ala Lys Phe Phe 100 105 110 Asn Ala Asn Gln Trp Ala Asp Ile Phe Gln Ala Ser Gly Ala Lys Tyr 115 120 125 Ile Val Leu Thr Ser Lys His His Glu Gly Phe Thr Leu Trp Gly Ser 130 135 140 Glu Tyr Ser Trp Asn Trp Asn Ala Ile Asp Glu Gly Pro Lys Arg Asp 145 150 155 160 Ile Val Lys Glu Leu Glu Val Ala Ile Arg Asn Arg Thr Asp Leu Arg 165 170 175 Phe Gly Leu Tyr Tyr Ser Leu Phe Glu Trp Phe His Pro Leu Phe Leu 180 185 190 Glu Asp Glu Ser Ser Ser Phe His Lys Arg Gln Phe Pro Val Ser Lys 195 200 205 Thr Leu Pro Glu Leu Tyr Glu Leu Val Asn Asn Tyr Gln Pro Glu Val 210 215 220 Leu Trp Ser Asp Gly Asp Gly Gly Ala Pro Asp Gln Tyr Trp Asn Ser 225 230 235 240 Thr Gly Phe Leu Ala Trp Leu Tyr Asn Glu Ser Pro Val Arg Gly Thr 245 250 255 Val Val Thr Asn Asp Arg Trp Gly Ala Gly Ser Ile Cys Lys His Gly 260 265 270 Gly Phe Tyr Thr Cys Ser Asp Arg Tyr Asn Pro Gly His Leu Leu Pro 275 280 285 His Lys Trp Glu Asn Cys Met Thr Ile Asp Lys Leu Ser Trp Gly Tyr 290 295 300 Arg Arg Glu Ala Gly Ile Ser Asp Tyr Leu Thr Ile Glu Glu Leu Val 305 310 315 320 Lys Gln Leu Val Glu Thr Val Ser Cys Gly Gly Asn Leu Leu Met Asn 325 330 335 Ile Gly Pro Thr Leu Asp Gly Thr Ile Ser Val Val Phe Glu Glu Arg 340 345 350 Leu Arg Gln Val Gly Ser Trp Leu Lys Val Asn Gly Glu Ala Ile Tyr 355 360 365 Glu Thr Tyr Thr Trp Arg Ser Gln Asn Asp Thr Val Thr Pro Asp Val 370 375 380 Trp Tyr Thr Ser Lys Pro Lys Glu Lys Leu Val Tyr Ala Ile Phe Pro 385 390 395 400 Lys Trp Pro Thr Ser Gly Gln Leu Phe Leu Gly His Pro Lys Ala Ile 405 410 415 Leu Gly Ala Thr Glu Val Lys Leu Leu Gly His Gly Gln Pro Leu Asn 420 425 430 Trp Ile Ser Leu Glu Gln Asn Gly Ile Met Val Glu Leu Pro Gln Leu 435 440 445 Thr Ile His Gln Met Pro Cys Lys Trp Gly Trp Ala Leu Ala Leu Thr 450 455 460 Asn Val Ile 465 <210> 171 <211> 2130 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (20)..(1141) <400> 171 acatggcccg cgggacaac atg gct gcg ccc gca cta ggg ctg gtg tgt gga 52 Met Ala Ala Pro Ala Leu Gly Leu Val Cys Gly 1 5 10 cgt tgc cct gag ctg ggt ctc gtc ctc ttg ctg ctg ctg ctc tcg ctg 100 Arg Cys Pro Glu Leu Gly Leu Val Leu Leu Leu Leu Leu Leu Ser Leu 15 20 25 ctg tgt gga gcg gca ggg agc cag gag gcc ggg acc ggt gcg ggc gcg 148 Leu Cys Gly Ala Ala Gly Ser Gln Glu Ala Gly Thr Gly Ala Gly Ala 30 35 40 ggg tcc ctt gcg ggt tct tgc ggc tgc ggc acg ccc cag cgg cct ggc 196 Gly Ser Leu Ala Gly Ser Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly 45 50 55 gcc cat ggc agt tcg gca gcc gct cac cga tac tcg cgg gag gct aac 244 Ala His Gly Ser Ser Ala Ala Ala His Arg Tyr Ser Arg Glu Ala Asn 60 65 70 75 gct ccg ggc ccc gta ccc gga gag cgg caa ctc gcg cac tca aag atg 292 Ala Pro Gly Pro Val Pro Gly Glu Arg Gln Leu Ala His Ser Lys Met 80 85 90 gtc ccc atc cct gct gga gta ttt aca atg ggc aca gat gat cct cag 340 Val Pro Ile Pro Ala Gly Val Phe Thr Met Gly Thr Asp Asp Pro Gln 95 100 105 ata aag cag gat ggg gaa gca cct gcg agg aga gtt act att gat gcc 388 Ile Lys Gln Asp Gly Glu Ala Pro Ala Arg Arg Val Thr Ile Asp Ala 110 115 120 ctt tac atg gat gcc tat gaa gtc agt aat act gaa ttt gag aag ttt 436 Leu Tyr Met Asp Ala Tyr Glu Val Ser Asn Thr Glu Phe Glu Lys Phe 125 130 135 gtg aac tca act ggc tat ttg aca gag gct gag aag ttt ggc gac tcc 484 Val Asn Ser Thr Gly Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser 140 145 150 155 ttt gtc ttt gaa ggc atg ttg agt gag caa gtg aag acc aat att caa 532 Phe Val Phe Glu Gly Met Leu Ser Glu Gln Val Lys Thr Asn Ile Gln 160 165 170 cag gca gtt gca gct gct ccc tgg tgg tta cct gtg aaa ggc gct aac 580 Gln Ala Val Ala Ala Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn 175 180 185 tgg aga cac cca gaa ggg cct gac tct act att ctg cac agg ccg gat 628 Trp Arg His Pro Glu Gly Pro Asp Ser Thr Ile Leu His Arg Pro Asp 190 195 200 cat cca gtt ctc cat gtg tcc tgg aat gat gcg gtt gcc tac tgc act 676 His Pro Val Leu His Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr 205 210 215 tgg gca ggg aag cgg ctg ccc acg gaa gct gag tgg gaa tac agc tgt 724 Trp Ala Gly Lys Arg Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys 220 225 230 235 cga gga ggc ctg cat aat aga ctt ttc ccc tgg ggc aac aaa ctg cag 772 Arg Gly Gly Leu His Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln 240 245 250 ccc aaa ggc cag cat tat gcc aac att tgg cag ggc gat ttt ccg gtg 820 Pro Lys Gly Gln His Tyr Ala Asn Ile Trp Gln Gly Asp Phe Pro Val 255 260 265 acc aac act ggt gag gat ggc ttc caa gga act gcg cct gtt gat gcc 868 Thr Asn Thr Gly Glu Asp Gly Phe Gln Gly Thr Ala Pro Val Asp Ala 270 275 280 ttc cct ccc aat ggt tat ggc tta tac aac ata gtg ggg aac gca tgg 916 Phe Pro Pro Asn Gly Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp 285 290 295 gaa tgg act tca gac tgg tgg act gtt cat cat tct gtt gaa gaa acg 964 Glu Trp Thr Ser Asp Trp Trp Thr Val His His Ser Val Glu Glu Thr 300 305 310 315 ctt aac cca aaa ggt ccc cct tct ggg aaa gac cga gtg aag aaa ggt 1012 Leu Asn Pro Lys Gly Pro Pro Ser Gly Lys Asp Arg Val Lys Lys Gly 320 325 330 gga tcc tac atg tgc cat agg tct tat tgt tac agg tat cgc tgt gct 1060 Gly Ser Tyr Met Cys His Arg Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala 335 340 345 gct cgg agc cag aac aca cct gat agc tct gct tcg aat ctg gga ttc 1108 Ala Arg Ser Gln Asn Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe 350 355 360 cgc tgt gca gcc gac cgc ctg ccc acc atg gac tgacaaccaa gggtagtctt 1161 Arg Cys Ala Ala Asp Arg Leu Pro Thr Met Asp 365 370 ccccagtcca aggagcagtc gtgtctgacc tacattgggc tttcctcaga actttgaacg 1221 atcccatgca aagaattccc accctgaggt gggttacata cctgcccaat ggccaaagga 1281 accgccttgt gagaccaaat tgctgacctg ggtcagtgca tgtgctttat ggtgtggtgc 1341 atctttggag atcatcacca tattttactt ttgagagtct ttaaagagga aggggagtgg 1401 agggaaccct gagctaggct tcaggaggcc cgcatcctac gcaggctctg ccacaggggt 1461 tagaccccag gtccgacgct tgaccttcct gggcctcaag tgccctcccc tatcaaatga 1521 aggaatggac agcatgacct ctgggtgtct ctccaactca ccagttctaa aaagggtatc 1581 agattctatt gtgacttcat agaatttatg atagattatt ttttagctat tttttccatg 1641 tgtgaacctt gagtgatact aatcatgtaa agtaagagtt ctcttatgta ttatgttcgg 1701 aagaggggtg tggtgactcc tttatattcg tactgcactt tgtttttcca aggaaatcag 1761 tgtcttttac gttgttatga tgaatcccac atggggccgg tgatggtatg ctgaagttca 1821 gccgttgaac acataggaat gtctgtgggg tgactctact gtgctttatc ttttaacatt 1881 aagtgccttt ggttcagagg ggcagtcata agctctgttt ccccctctcc ccaaagcctt 1941 cagcgaacgt gaaatgtgcg ctaaacgggg aaacctgttt aattctagat atagggaaaa 2001 aggaacgagg accttgaatg agctatattc agggtatccg gtattttgta atagggaata 2061 ggaaaccttg ttggctgtgg aatatccgat gctttgaatc atgcactgtg ttgaataaac 2121 gtatctgct 2130 <210> 172 <211> 374 <212> PRT <213> Homo sapiens <400> 172 Met Ala Ala Pro Ala Leu Gly Leu Val Cys Gly Arg Cys Pro Glu Leu 1 5 10 15 Gly Leu Val Leu Leu Leu Leu Leu Leu Ser Leu Leu Cys Gly Ala Ala 20 25 30 Gly Ser Gln Glu Ala Gly Thr Gly Ala Gly Ala Gly Ser Leu Ala Gly 35 40 45 Ser Cys Gly Cys Gly Thr Pro Gln Arg Pro Gly Ala His Gly Ser Ser 50 55 60 Ala Ala Ala His Arg Tyr Ser Arg Glu Ala Asn Ala Pro Gly Pro Val 65 70 75 80 Pro Gly Glu Arg Gln Leu Ala His Ser Lys Met Val Pro Ile Pro Ala 85 90 95 Gly Val Phe Thr Met Gly Thr Asp Asp Pro Gln Ile Lys Gln Asp Gly 100 105 110 Glu Ala Pro Ala Arg Arg Val Thr Ile Asp Ala Leu Tyr Met Asp Ala 115 120 125 Tyr Glu Val Ser Asn Thr Glu Phe Glu Lys Phe Val Asn Ser Thr Gly 130 135 140 Tyr Leu Thr Glu Ala Glu Lys Phe Gly Asp Ser Phe Val Phe Glu Gly 145 150 155 160 Met Leu Ser Glu Gln Val Lys Thr Asn Ile Gln Gln Ala Val Ala Ala 165 170 175 Ala Pro Trp Trp Leu Pro Val Lys Gly Ala Asn Trp Arg His Pro Glu 180 185 190 Gly Pro Asp Ser Thr Ile Leu His Arg Pro Asp His Pro Val Leu His 195 200 205 Val Ser Trp Asn Asp Ala Val Ala Tyr Cys Thr Trp Ala Gly Lys Arg 210 215 220 Leu Pro Thr Glu Ala Glu Trp Glu Tyr Ser Cys Arg Gly Gly Leu His 225 230 235 240 Asn Arg Leu Phe Pro Trp Gly Asn Lys Leu Gln Pro Lys Gly Gln His 245 250 255 Tyr Ala Asn Ile Trp Gln Gly Asp Phe Pro Val Thr Asn Thr Gly Glu 260 265 270 Asp Gly Phe Gln Gly Thr Ala Pro Val Asp Ala Phe Pro Pro Asn Gly 275 280 285 Tyr Gly Leu Tyr Asn Ile Val Gly Asn Ala Trp Glu Trp Thr Ser Asp 290 295 300 Trp Trp Thr Val His His Ser Val Glu Glu Thr Leu Asn Pro Lys Gly 305 310 315 320 Pro Pro Ser Gly Lys Asp Arg Val Lys Lys Gly Gly Ser Tyr Met Cys 325 330 335 His Arg Ser Tyr Cys Tyr Arg Tyr Arg Cys Ala Ala Arg Ser Gln Asn 340 345 350 Thr Pro Asp Ser Ser Ala Ser Asn Leu Gly Phe Arg Cys Ala Ala Asp 355 360 365 Arg Leu Pro Thr Met Asp 370 <210> 173 <211> 1836 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (150)..(560) <400> 173 ctgtcagcgc ctttgtgagg agaaatgtgg ctgtctacta cgtgtcctat gctgtcttcg 60 ttgtcaccta cctgatcctt gcctgctgcc agggacccag acgccgtttc ccatggaaca 120 tcattctgct gacccttttt acttttgcc atg ggc ttc atg acg ggc acc att 173 Met Gly Phe Met Thr Gly Thr Ile 1 5 tcc agt atg tac caa acc aaa gcc gtc atc att gca atg atc atc act 221 Ser Ser Met Tyr Gln Thr Lys Ala Val Ile Ile Ala Met Ile Ile Thr 10 15 20 gcg gtg gta tcc att tca gtc acc atc ttc tgc ttt cag acc aag gtg 269 Ala Val Val Ser Ile Ser Val Thr Ile Phe Cys Phe Gln Thr Lys Val 25 30 35 40 gac ttc acc tcg tgc aca ggc ctc ttc tgt gtc ctg gga att gtg ctc 317 Asp Phe Thr Ser Cys Thr Gly Leu Phe Cys Val Leu Gly Ile Val Leu 45 50 55 ctg gtg act ggg att gtc act agc att gtg ctc tac ttc caa tac gtt 365 Leu Val Thr Gly Ile Val Thr Ser Ile Val Leu Tyr Phe Gln Tyr Val 60 65 70 tac tgg ctc cac atg ctc tat gct gct ctg ggg gcc att tgt ttc acc 413 Tyr Trp Leu His Met Leu Tyr Ala Ala Leu Gly Ala Ile Cys Phe Thr 75 80 85 ctg ttc ctg gct tac gac aca cag ctg gtc ctg ggg aac cgg aag cac 461 Leu Phe Leu Ala Tyr Asp Thr Gln Leu Val Leu Gly Asn Arg Lys His 90 95 100 acc atc agc ccc gag gac tac atc act ggc gcc ctg cag att tac aca 509 Thr Ile Ser Pro Glu Asp Tyr Ile Thr Gly Ala Leu Gln Ile Tyr Thr 105 110 115 120 gac atc atc tac atc ttc acc ttt gtg ctg cag ctg atg ggg gat cgc 557 Asp Ile Ile Tyr Ile Phe Thr Phe Val Leu Gln Leu Met Gly Asp Arg 125 130 135 aat taaggagcaa gcccccattt tcacccgatc ctgggctctc ccttccaagc 610 Asn tagagggctg ggccctatga ctgtggtctg ggctttaggc ccctttcctt ccccttgagt 670 aacatgccca gtttcctttc tgtcctggag acaggtggcc tctctggcta tggatgtgtg 730 ggtacttggt ggggacggag gagctaggga ctaactgttg ctcttggtgg gcttggcagg 790 gactaggctg aagatgtgtc ttctccccgc cacctactgt atgacaccac attcttccta 850 acagctgggg ttgtgaggaa tatgaaaaga gcctattcga tagctagaag ggaatatgaa 910 aggtagaagt gacttcaagg tcacgaggtt cccctcccac ctctgtcaca ggcttcttga 970 ctacgtagtt ggagctattt cctcccccag caaagccaga gagctttgtc cccggcctcc 1030 tggacacata ggccattatc ctgtattcct ttggcttggc atcttttagc tcaggaaggt 1090 agaagagatc tgtgcccatg ggtctccttg cttcaatccc ttcttgtttc agtgacatat 1150 gtattgttta tctgggttag ggatggggga cagataatag aacgagcaaa gtaacctata 1210 caggccagca tggaacagca tctcccctgg gcttgctcct ggcttgtgac gctataagac 1270 agagcagcca catgtggcca tctgctcccc attcttgaaa gctgctgggg cctccttgca 1330 ggcttctgga tctctggtca gagtgaactc ttgcttcctg tattcaggca gctcagagca 1390 gaaagtaagg ggcagagtca tacgtgtggc caggaagtag ccagggtgaa gagagactcg 1450 gtgcgggcag ggagaatgcc tgggggtccc tcacctggct agggagatac cgaagcctac 1510 tgtggtactg aagacttctg ggttctttcc ttctgctaac ccagggaggg tcctaagagg 1570 aaggtgactt ctctctgttt gtcttaagtt gcactggggg atttctgact tgaggcccat 1630 ctctccagcc agccactccc ttctttgtaa tattaagtgc cttgagctgg aatggggaag 1690 ggggacaagg gtcagtctgt cgggtggggg cagaaatcaa atcagcccaa ggatatagtt 1750 aggattaatt acttaataga gaaatcctaa ctatatcaca caaagggata caactataaa 1810 tgtaataaaa tttatgtcta gaagtt 1836 <210> 174 <211> 137 <212> PRT <213> Homo sapiens <400> 174 Met Gly Phe Met Thr Gly Thr Ile Ser Ser Met Tyr Gln Thr Lys Ala 1 5 10 15 Val Ile Ile Ala Met Ile Ile Thr Ala Val Val Ser Ile Ser Val Thr 20 25 30 Ile Phe Cys Phe Gln Thr Lys Val Asp Phe Thr Ser Cys Thr Gly Leu 35 40 45 Phe Cys Val Leu Gly Ile Val Leu Leu Val Thr Gly Ile Val Thr Ser 50 55 60 Ile Val Leu Tyr Phe Gln Tyr Val Tyr Trp Leu His Met Leu Tyr Ala 65 70 75 80 Ala Leu Gly Ala Ile Cys Phe Thr Leu Phe Leu Ala Tyr Asp Thr Gln 85 90 95 Leu Val Leu Gly Asn Arg Lys His Thr Ile Ser Pro Glu Asp Tyr Ile 100 105 110 Thr Gly Ala Leu Gln Ile Tyr Thr Asp Ile Ile Tyr Ile Phe Thr Phe 115 120 125 Val Leu Gln Leu Met Gly Asp Arg Asn 130 135 <210> 175 <211> 2198 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (123)..(1238) <400> 175 aaaaaactct ttcttcggct cgcgagctga gaggagcagg tagaggggca gaggcgggac 60 tgtcgtctgg gggagccgcc caggaggctc ctcaggccga ccccagtccc tggctggcca 120 gg atg aag tat ctc cgg cac cgg cgg ccc aat gcc acc ctc att ctg 167 Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu 1 5 10 15 gcc atc ggc gct ttc acc ctc ctc ctc ttc agt ctg cta gtg tca cca 215 Ala Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro 20 25 30 ccc acc tgc aag gtc cag gag cag cca ccg gcg atc ccc gag gcc ctg 263 Pro Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu 35 40 45 gcc tgg ccc act cca ccc acc cgc cca gcc ccg gcc ccg tgc cat gcc 311 Ala Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala 50 55 60 aac acc tct atg gtc acc cac ccg aac ttc gcc acg cag ccg cag cac 359 Asn Thr Ser Met Val Thr His Pro Asn Phe Ala Thr Gln Pro Gln His 65 70 75 gtt cag aac ttc ctc ctg tac aga cac tgc cgc cac ttt ccc ctg ctg 407 Val Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Phe Pro Leu Leu 80 85 90 95 cag gac gtg ccc ccc tct aag tgc gcg cag ccg gtc ttc ctg ctg ctg 455 Gln Asp Val Pro Pro Ser Lys Cys Ala Gln Pro Val Phe Leu Leu Leu 100 105 110 gtg atc aag tcc tcc cct agc aac tat gtg cgc cgc gag ctg ctg cgg 503 Val Ile Lys Ser Ser Pro Ser Asn Tyr Val Arg Arg Glu Leu Leu Arg 115 120 125 cgc acg tgg ggc cgc gag cgc aag gta cgg ggt ttg cag ctg cgc ctc 551 Arg Thr Trp Gly Arg Glu Arg Lys Val Arg Gly Leu Gln Leu Arg Leu 130 135 140 ctc ttc ctg gtg ggc aca gcc tcc aac ccg cac gag gcc cgc aag gtc 599 Leu Phe Leu Val Gly Thr Ala Ser Asn Pro His Glu Ala Arg Lys Val 145 150 155 aac cgg ctg ctg gag ctg gag gca cag act cac gga gac atc ctg cag 647 Asn Arg Leu Leu Glu Leu Glu Ala Gln Thr His Gly Asp Ile Leu Gln 160 165 170 175 tgg gac ttc cac gac tcc ttc ttc aac ctc acg ctc aag cag gtc ctg 695 Trp Asp Phe His Asp Ser Phe Phe Asn Leu Thr Leu Lys Gln Val Leu 180 185 190 ttc tta cag tgg cag gag aca agg tgc gcc aac gcc agc ttc gtg ctc 743 Phe Leu Gln Trp Gln Glu Thr Arg Cys Ala Asn Ala Ser Phe Val Leu 195 200 205 aac ggg gat gat gac gtc ttt gca cac aca gac aac atg gtc ttc tac 791 Asn Gly Asp Asp Asp Val Phe Ala His Thr Asp Asn Met Val Phe Tyr 210 215 220 ctg cag gac cat gac cct ggc cgc cac ctc ttc gtg ggg caa ctg atc 839 Leu Gln Asp His Asp Pro Gly Arg His Leu Phe Val Gly Gln Leu Ile 225 230 235 caa aac gtg ggc ccc atc cgg gct ttt tgg agc aag tac tat gtg cca 887 Gln Asn Val Gly Pro Ile Arg Ala Phe Trp Ser Lys Tyr Tyr Val Pro 240 245 250 255 gag gtg gtg act cag aat gag cgg tac cca ccc tat tgt ggg ggt ggt 935 Glu Val Val Thr Gln Asn Glu Arg Tyr Pro Pro Tyr Cys Gly Gly Gly 260 265 270 ggc ttc ttg ctg tcc cgc ttc acg gcc gct gcc ctg cgc cgt gct gcc 983 Gly Phe Leu Leu Ser Arg Phe Thr Ala Ala Ala Leu Arg Arg Ala Ala 275 280 285 cat gtc ttg gac atc ttc ccc att gat gat gtc ttc ctg ggt atg tgt 1031 His Val Leu Asp Ile Phe Pro Ile Asp Asp Val Phe Leu Gly Met Cys 290 295 300 ctg gag ctt gag gga ctg aag cct gcc tcc cac agc ggc atc cgc acg 1079 Leu Glu Leu Glu Gly Leu Lys Pro Ala Ser His Ser Gly Ile Arg Thr 305 310 315 tct ggc gtg cgg gct cca tcg caa cgc ctg tcc tcc ttt gac ccc tgc 1127 Ser Gly Val Arg Ala Pro Ser Gln Arg Leu Ser Ser Phe Asp Pro Cys 320 325 330 335 ttc tac cga gac ctg ctg ctg gtg cac cgc ttc cta cct tat gag atg 1175 Phe Tyr Arg Asp Leu Leu Leu Val His Arg Phe Leu Pro Tyr Glu Met 340 345 350 ctg ctc atg tgg gat gcg ctg aac cgg ccc aac ctc acc tgc ggc aat 1223 Leu Leu Met Trp Asp Ala Leu Asn Arg Pro Asn Leu Thr Cys Gly Asn 355 360 365 cag aca cag atc tac tgagtcagca tcagggtccc cagcctctgg gctcctgttt 1278 Gln Thr Gln Ile Tyr 370 ccataggaag gggcgacacc ttcctcccag gaagctgaga cctttgtggt ctgagcataa 1338 gggagtgcca gggaaggttt gaggtttgat gagtgaatat actggctggc gaactcctac 1398 acatccttca aaacccacct ggtactgttc cagcatcttc cctggatggc tggaggaact 1458 ccagaaaata tccatcttct ttttgtggct gctaatggca gaagtgcctg tgctagagtt 1518 ccaactgtgg atgcatccgt cccgtttgag tcaaagtctt acttccctgc tctcacctac 1578 tcacagacgg gatgctaagc agtgcacctg cagtggttta atggcagata agctccgtct 1638 gcagttccag gccagccaga aactcctgtg cacatagagc tgacgtgaga aatatctttc 1698 agcccaggag agaggggtcc tgatcttaac cctttcctgg gcctcagaca actcagaagg 1758 ttggggggat accagagagg tggtggaata ggaccgcccc ctccttactt gtgggatcaa 1818 atgctgtaat ggtggaggtg tgggcagagg agggaggcaa gtgtcctttg aaagttgtga 1878 gagctcagag tttctggggt cctcattagg agcccccatc cctgtgttcc ccaagaattc 1938 agagaacagc actggggctg gaatgatctt taatgggccc aaggccaaca ggcatatgcc 1998 tcactactgc ctggagaagg gagagattca ggtcctccag cagcctccct cgcccagtat 2058 gttttacaga ttacgggggg accgggtgag ccagtgaccc cctgtagccc ccagcttcag 2118 gcctcagtgt ctgccagtca agcttcacag gcattgtgat ggggcagcct tggggaatat 2178 aaaattttgt gaagacttgg 2198 <210> 176 <211> 372 <212> PRT <213> Homo sapiens <400> 176 Met Lys Tyr Leu Arg His Arg Arg Pro Asn Ala Thr Leu Ile Leu Ala 1 5 10 15 Ile Gly Ala Phe Thr Leu Leu Leu Phe Ser Leu Leu Val Ser Pro Pro 20 25 30 Thr Cys Lys Val Gln Glu Gln Pro Pro Ala Ile Pro Glu Ala Leu Ala 35 40 45 Trp Pro Thr Pro Pro Thr Arg Pro Ala Pro Ala Pro Cys His Ala Asn 50 55 60 Thr Ser Met Val Thr His Pro Asn Phe Ala Thr Gln Pro Gln His Val 65 70 75 80 Gln Asn Phe Leu Leu Tyr Arg His Cys Arg His Phe Pro Leu Leu Gln 85 90 95 Asp Val Pro Pro Ser Lys Cys Ala Gln Pro Val Phe Leu Leu Leu Val 100 105 110 Ile Lys Ser Ser Pro Ser Asn Tyr Val Arg Arg Glu Leu Leu Arg Arg 115 120 125 Thr Trp Gly Arg Glu Arg Lys Val Arg Gly Leu Gln Leu Arg Leu Leu 130 135 140 Phe Leu Val Gly Thr Ala Ser Asn Pro His Glu Ala Arg Lys Val Asn 145 150 155 160 Arg Leu Leu Glu Leu Glu Ala Gln Thr His Gly Asp Ile Leu Gln Trp 165 170 175 Asp Phe His Asp Ser Phe Phe Asn Leu Thr Leu Lys Gln Val Leu Phe 180 185 190 Leu Gln Trp Gln Glu Thr Arg Cys Ala Asn Ala Ser Phe Val Leu Asn 195 200 205 Gly Asp Asp Asp Val Phe Ala His Thr Asp Asn Met Val Phe Tyr Leu 210 215 220 Gln Asp His Asp Pro Gly Arg His Leu Phe Val Gly Gln Leu Ile Gln 225 230 235 240 Asn Val Gly Pro Ile Arg Ala Phe Trp Ser Lys Tyr Tyr Val Pro Glu 245 250 255 Val Val Thr Gln Asn Glu Arg Tyr Pro Pro Tyr Cys Gly Gly Gly Gly 260 265 270 Phe Leu Leu Ser Arg Phe Thr Ala Ala Ala Leu Arg Arg Ala Ala His 275 280 285 Val Leu Asp Ile Phe Pro Ile Asp Asp Val Phe Leu Gly Met Cys Leu 290 295 300 Glu Leu Glu Gly Leu Lys Pro Ala Ser His Ser Gly Ile Arg Thr Ser 305 310 315 320 Gly Val Arg Ala Pro Ser Gln Arg Leu Ser Ser Phe Asp Pro Cys Phe 325 330 335 Tyr Arg Asp Leu Leu Leu Val His Arg Phe Leu Pro Tyr Glu Met Leu 340 345 350 Leu Met Trp Asp Ala Leu Asn Arg Pro Asn Leu Thr Cys Gly Asn Gln 355 360 365 Thr Gln Ile Tyr 370 <210> 177 <211> 2222 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (45)..(1532) <400> 177 aaaaaaaatt ccgccaagtc tctcgctctg cccaggacgc acag atg aga gcg ctc 56 Met Arg Ala Leu 1 cga aga ctg att cag ggc agg atc ctg ctc ctg acc atc tgc gct gcc 104 Arg Arg Leu Ile Gln Gly Arg Ile Leu Leu Leu Thr Ile Cys Ala Ala 5 10 15 20 ggc att ggt ggg act ttt cag ttt ggc tat aac ctc tct atc atc aat 152 Gly Ile Gly Gly Thr Phe Gln Phe Gly Tyr Asn Leu Ser Ile Ile Asn 25 30 35 gcc ccg acc ttg cac att cag gaa ttc acc aat gag aca tgg cag gcg 200 Ala Pro Thr Leu His Ile Gln Glu Phe Thr Asn Glu Thr Trp Gln Ala 40 45 50 cgt act gga gag cca ctg ccc gat cac cta gtc ctg ctt atg tgg tcc 248 Arg Thr Gly Glu Pro Leu Pro Asp His Leu Val Leu Leu Met Trp Ser 55 60 65 ctc atc gtg tct ctg tat ccc ctg gga ggc ctc ttt gga gca ctg ctt 296 Leu Ile Val Ser Leu Tyr Pro Leu Gly Gly Leu Phe Gly Ala Leu Leu 70 75 80 gca ggt ccc ttg gcc atc acg ctg gga agg aag aag tcc ctc ctg gtg 344 Ala Gly Pro Leu Ala Ile Thr Leu Gly Arg Lys Lys Ser Leu Leu Val 85 90 95 100 aat aac atc ttt gtg gtg tca gca gca atc ctg ttt gga ttc agc cgc 392 Asn Asn Ile Phe Val Val Ser Ala Ala Ile Leu Phe Gly Phe Ser Arg 105 110 115 aaa gca ggc tcc ttt gag atg atc atg ctg gga aga ctg ctc gtg gga 440 Lys Ala Gly Ser Phe Glu Met Ile Met Leu Gly Arg Leu Leu Val Gly 120 125 130 gtc aat gca ggt gtg agc atg aac atc cag ccc atg tac ctg ggg gag 488 Val Asn Ala Gly Val Ser Met Asn Ile Gln Pro Met Tyr Leu Gly Glu 135 140 145 agc gcc cct aag gag ctc cga gga gct gtg gcc atg agc tca gcc atc 536 Ser Ala Pro Lys Glu Leu Arg Gly Ala Val Ala Met Ser Ser Ala Ile 150 155 160 ttt acg gct ctg ggg atc gtg atg gga cag gtg gtc gga ctc agg gag 584 Phe Thr Ala Leu Gly Ile Val Met Gly Gln Val Val Gly Leu Arg Glu 165 170 175 180 ctc cta ggt ggc cct cag gcc tgg ccc ctg ctg ctg gcc agc tgc ctg 632 Leu Leu Gly Gly Pro Gln Ala Trp Pro Leu Leu Leu Ala Ser Cys Leu 185 190 195 gtg ccc ggg gcg ctc cag ctc gcc tcc ctg cct ctg ctc cct gaa agc 680 Val Pro Gly Ala Leu Gln Leu Ala Ser Leu Pro Leu Leu Pro Glu Ser 200 205 210 ccg cgc tac ctc ctc att gac tgt gga gac acc gag gcc tgc ctg gca 728 Pro Arg Tyr Leu Leu Ile Asp Cys Gly Asp Thr Glu Ala Cys Leu Ala 215 220 225 gca cta cgg cgg ctc cgg ggc tcc ggg gac ttg gca ggg gag ctg gag 776 Ala Leu Arg Arg Leu Arg Gly Ser Gly Asp Leu Ala Gly Glu Leu Glu 230 235 240 gag ctg gag gag gag cgc gct gcc tgc cag ggc tgc cgt gcc cgg cgc 824 Glu Leu Glu Glu Glu Arg Ala Ala Cys Gln Gly Cys Arg Ala Arg Arg 245 250 255 260 cca tgg gag ctg ttc cag cat cgg gcc ctg agg aga cag gtg aca agc 872 Pro Trp Glu Leu Phe Gln His Arg Ala Leu Arg Arg Gln Val Thr Ser 265 270 275 ctc gtg gtt ctg ggc agt gcc atg gag ctc tgc ggg aat gac tcg gtg 920 Leu Val Val Leu Gly Ser Ala Met Glu Leu Cys Gly Asn Asp Ser Val 280 285 290 tac gcc tac gcc tcc tcc gtg ttc cgg aag gca gga gtg ccg gaa gcg 968 Tyr Ala Tyr Ala Ser Ser Val Phe Arg Lys Ala Gly Val Pro Glu Ala 295 300 305 aag atc cag tac gcg atc atc ggg act ggg agc tgc gag ctg ctc acg 1016 Lys Ile Gln Tyr Ala Ile Ile Gly Thr Gly Ser Cys Glu Leu Leu Thr 310 315 320 gcg gtt gtt agt tgt gtg gta atc gag agg gtg ggt cgg cgc gtg ctg 1064 Ala Val Val Ser Cys Val Val Ile Glu Arg Val Gly Arg Arg Val Leu 325 330 335 340 ctc atc ggt ggg tac agc ctg atg acc tgc tgg ggg agc atc ttc act 1112 Leu Ile Gly Gly Tyr Ser Leu Met Thr Cys Trp Gly Ser Ile Phe Thr 345 350 355 gtg gcc ctg tgc ctg cag agc tcc ttc ccc tgg aca ctc tac ctg gcc 1160 Val Ala Leu Cys Leu Gln Ser Ser Phe Pro Trp Thr Leu Tyr Leu Ala 360 365 370 atg gcc tgc atc ttt gcc ttc atc ctc agc ttt ggc att ggc cct gcc 1208 Met Ala Cys Ile Phe Ala Phe Ile Leu Ser Phe Gly Ile Gly Pro Ala 375 380 385 gga gtg acg ggg atc ctg gcc aca gag ctg ttt gac cag atg gcc agg 1256 Gly Val Thr Gly Ile Leu Ala Thr Glu Leu Phe Asp Gln Met Ala Arg 390 395 400 cct gct gcc tgc atg gtc tgc ggg gcg ctc atg tgg atc atg ctc atc 1304 Pro Ala Ala Cys Met Val Cys Gly Ala Leu Met Trp Ile Met Leu Ile 405 410 415 420 ctg gtc ggc ctg gga ttt ccc ttt atc atg gag gcc ttg tcc cac ttc 1352 Leu Val Gly Leu Gly Phe Pro Phe Ile Met Glu Ala Leu Ser His Phe 425 430 435 ctc tat gtc cct ttc ctt ggt gtc tgt gtc tgt ggg gcc atc tac act 1400 Leu Tyr Val Pro Phe Leu Gly Val Cys Val Cys Gly Ala Ile Tyr Thr 440 445 450 ggc ctg ttc ctt cct gag acc aaa ggc aag acc ttc caa gag atc tcc 1448 Gly Leu Phe Leu Pro Glu Thr Lys Gly Lys Thr Phe Gln Glu Ile Ser 455 460 465 aag gaa tta cac aga ctc aac ttc ccc agg cgg gcc cag ggc ccc acg 1496 Lys Glu Leu His Arg Leu Asn Phe Pro Arg Arg Ala Gln Gly Pro Thr 470 475 480 tgg agg agc ctg gag gtt atc cag tca aca gaa ctc tagtcccaaa 1542 Trp Arg Ser Leu Glu Val Ile Gln Ser Thr Glu Leu 485 490 495 ggggtggcca gagccaaagc cagctactgt cctgtcctct gcttcctgcc agggccctgg 1602 tcctcactcc ctcctgcatt cctcatttaa ggagtgttta ttgagcaccc tttgtgtgca 1662 gacatggctc caggtgctta gcaatcaatg gtgagcgtgg tattccaggc taaaggtaat 1722 taactgacag aaaatcagta acaacataat tacaggctgg ttgtggcagc tcatgactgt 1782 aatcccagca ctttgggagg ccaaggtggg aggatcaatt gaggccagag tttgaaacca 1842 gcctaggtaa catagtgaga ccccctacct ctacaaaaaa ttttaaacat tagctgggca 1902 tggtggtatg tgctaacagc tctagctact caggaggctg aggcagcagg atcacttgag 1962 tccaagagtt caaggtagca gtaagctaca atcacaccac tgcatgccag actgggtgac 2022 agagggagac ttcatctctt taaaacataa taataataat tacagactca ggaaatgcag 2082 tgaaagaaaa atacaggttg gccaggtgag gtggctgatg cctgtaatcc cagcactttg 2142 ggaggccaag atgggaagat tgctttgaga ccagaagttt gagaccagcc tgggccacat 2202 agtaagatcc tgtttctacc 2222 <210> 178 <211> 496 <212> PRT <213> Homo sapiens <400> 178 Met Arg Ala Leu Arg Arg Leu Ile Gln Gly Arg Ile Leu Leu Leu Thr 1 5 10 15 Ile Cys Ala Ala Gly Ile Gly Gly Thr Phe Gln Phe Gly Tyr Asn Leu 20 25 30 Ser Ile Ile Asn Ala Pro Thr Leu His Ile Gln Glu Phe Thr Asn Glu 35 40 45 Thr Trp Gln Ala Arg Thr Gly Glu Pro Leu Pro Asp His Leu Val Leu 50 55 60 Leu Met Trp Ser Leu Ile Val Ser Leu Tyr Pro Leu Gly Gly Leu Phe 65 70 75 80 Gly Ala Leu Leu Ala Gly Pro Leu Ala Ile Thr Leu Gly Arg Lys Lys 85 90 95 Ser Leu Leu Val Asn Asn Ile Phe Val Val Ser Ala Ala Ile Leu Phe 100 105 110 Gly Phe Ser Arg Lys Ala Gly Ser Phe Glu Met Ile Met Leu Gly Arg 115 120 125 Leu Leu Val Gly Val Asn Ala Gly Val Ser Met Asn Ile Gln Pro Met 130 135 140 Tyr Leu Gly Glu Ser Ala Pro Lys Glu Leu Arg Gly Ala Val Ala Met 145 150 155 160 Ser Ser Ala Ile Phe Thr Ala Leu Gly Ile Val Met Gly Gln Val Val 165 170 175 Gly Leu Arg Glu Leu Leu Gly Gly Pro Gln Ala Trp Pro Leu Leu Leu 180 185 190 Ala Ser Cys Leu Val Pro Gly Ala Leu Gln Leu Ala Ser Leu Pro Leu 195 200 205 Leu Pro Glu Ser Pro Arg Tyr Leu Leu Ile Asp Cys Gly Asp Thr Glu 210 215 220 Ala Cys Leu Ala Ala Leu Arg Arg Leu Arg Gly Ser Gly Asp Leu Ala 225 230 235 240 Gly Glu Leu Glu Glu Leu Glu Glu Glu Arg Ala Ala Cys Gln Gly Cys 245 250 255 Arg Ala Arg Arg Pro Trp Glu Leu Phe Gln His Arg Ala Leu Arg Arg 260 265 270 Gln Val Thr Ser Leu Val Val Leu Gly Ser Ala Met Glu Leu Cys Gly 275 280 285 Asn Asp Ser Val Tyr Ala Tyr Ala Ser Ser Val Phe Arg Lys Ala Gly 290 295 300 Val Pro Glu Ala Lys Ile Gln Tyr Ala Ile Ile Gly Thr Gly Ser Cys 305 310 315 320 Glu Leu Leu Thr Ala Val Val Ser Cys Val Val Ile Glu Arg Val Gly 325 330 335 Arg Arg Val Leu Leu Ile Gly Gly Tyr Ser Leu Met Thr Cys Trp Gly 340 345 350 Ser Ile Phe Thr Val Ala Leu Cys Leu Gln Ser Ser Phe Pro Trp Thr 355 360 365 Leu Tyr Leu Ala Met Ala Cys Ile Phe Ala Phe Ile Leu Ser Phe Gly 370 375 380 Ile Gly Pro Ala Gly Val Thr Gly Ile Leu Ala Thr Glu Leu Phe Asp 385 390 395 400 Gln Met Ala Arg Pro Ala Ala Cys Met Val Cys Gly Ala Leu Met Trp 405 410 415 Ile Met Leu Ile Leu Val Gly Leu Gly Phe Pro Phe Ile Met Glu Ala 420 425 430 Leu Ser His Phe Leu Tyr Val Pro Phe Leu Gly Val Cys Val Cys Gly 435 440 445 Ala Ile Tyr Thr Gly Leu Phe Leu Pro Glu Thr Lys Gly Lys Thr Phe 450 455 460 Gln Glu Ile Ser Lys Glu Leu His Arg Leu Asn Phe Pro Arg Arg Ala 465 470 475 480 Gln Gly Pro Thr Trp Arg Ser Leu Glu Val Ile Gln Ser Thr Glu Leu 485 490 495 <210> 179 <211> 1320 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (90)..(902) <400> 179 actcgatcag cccgccggct ccggagcggc tctgccttcc cgagcgcggg acgcggcgcc 60 ctgggggagg agggcgaagc gacgcggcg atg gct ccg cgg gca ctc ccg ggg 113 Met Ala Pro Arg Ala Leu Pro Gly 1 5 tcc gcc gtc cta gcc gct gct gtc ttc gtg gga ggc gcc gtg agt tcg 161 Ser Ala Val Leu Ala Ala Ala Val Phe Val Gly Gly Ala Val Ser Ser 10 15 20 ccg ctg gtg gct ccg gac aat ggg agc agc cgc gca ttg cac tcc aga 209 Pro Leu Val Ala Pro Asp Asn Gly Ser Ser Arg Ala Leu His Ser Arg 25 30 35 40 aca gag acg acc ccg tcg ccc agc aac gat act ggg aat gga cac cca 257 Thr Glu Thr Thr Pro Ser Pro Ser Asn Asp Thr Gly Asn Gly His Pro 45 50 55 gaa tat att gca tac gcg ctt gtc cct gtg ttc ttt atc atg ggt ctc 305 Glu Tyr Ile Ala Tyr Ala Leu Val Pro Val Phe Phe Ile Met Gly Leu 60 65 70 ttt ggc gtc ctc att tgc cac ctg ctt aag aag aaa ggc tat cgt tgt 353 Phe Gly Val Leu Ile Cys His Leu Leu Lys Lys Lys Gly Tyr Arg Cys 75 80 85 aca aca gaa gca gag caa gat atc gaa gag gaa aag gtt gaa aag ata 401 Thr Thr Glu Ala Glu Gln Asp Ile Glu Glu Glu Lys Val Glu Lys Ile 90 95 100 gaa ttg aat gac agt gtg aat gaa aac agt gac act gtt ggg caa atc 449 Glu Leu Asn Asp Ser Val Asn Glu Asn Ser Asp Thr Val Gly Gln Ile 105 110 115 120 gtc cac tac atc atg aaa aat gaa gcg aat gct gat gtc tta aag gcg 497 Val His Tyr Ile Met Lys Asn Glu Ala Asn Ala Asp Val Leu Lys Ala 125 130 135 atg gta gca gat aac agc ctg tat gat cct gaa agc ccc gtg acc ccc 545 Met Val Ala Asp Asn Ser Leu Tyr Asp Pro Glu Ser Pro Val Thr Pro 140 145 150 agc aca cca ggg agc ccg cca gtg agt cct ggg cct ttg tca cca ggg 593 Ser Thr Pro Gly Ser Pro Pro Val Ser Pro Gly Pro Leu Ser Pro Gly 155 160 165 ggg acg cca ggg aag cac gtc tgt ggc cat cat ctg cat acg gtg ggc 641 Gly Thr Pro Gly Lys His Val Cys Gly His His Leu His Thr Val Gly 170 175 180 ggt gtt gtc gag agg gat gtg tgt cat cgg tgt agg cac aag cgg tgg 689 Gly Val Val Glu Arg Asp Val Cys His Arg Cys Arg His Lys Arg Trp 185 190 195 200 cac ttt ata aag ccc act aac aag tcc aga gag agc aga cca cgg cgc 737 His Phe Ile Lys Pro Thr Asn Lys Ser Arg Glu Ser Arg Pro Arg Arg 205 210 215 caa ggc gag gtc acg gtc ctt tct gtt ggc aga ttt aga gtt aca aaa 785 Gln Gly Glu Val Thr Val Leu Ser Val Gly Arg Phe Arg Val Thr Lys 220 225 230 gtg gag cac aag tca aac cag aag gaa cgg aga agc ctg atg tct gtt 833 Val Glu His Lys Ser Asn Gln Lys Glu Arg Arg Ser Leu Met Ser Val 235 240 245 agt ggg gct gaa acc gtc aat ggg gag gtg ccg gca aca cct gtg aag 881 Ser Gly Ala Glu Thr Val Asn Gly Glu Val Pro Ala Thr Pro Val Lys 250 255 260 aga gaa cgc agt ggc aca gag tagcagtgtc ctgaatgaca gctcatctac 932 Arg Glu Arg Ser Gly Thr Glu 265 270 acagagtgaa actccagata tgtgacaagc agcatgggac agatgctgac aatcagaaca 992 gatgctggat gtaaacaact ggtaaggctg cactggtgca tgctggcaga atcacctgct 1052 atgcatccag ggagcaaatg catctgcatg ctcagcatga caccagctta cctccctgtg 1112 caaatcccct cccctaatca gtctcatcca aatcttctcc tgcagtagca gcttctaaag 1172 ctgcaagggc ctccgccacc gctgcatcct cgtccacaat ctccccatcc ccatctccat 1232 cggagccatg ggtatccccc tgcctgtttc ctgagtcaac cacaggcatg gcatgaacag 1292 gacccttctc attaaagcag atgcttag 1320 <210> 180 <211> 271 <212> PRT <213> Homo sapiens <400> 180 Met Ala Pro Arg Ala Leu Pro Gly Ser Ala Val Leu Ala Ala Ala Val 1 5 10 15 Phe Val Gly Gly Ala Val Ser Ser Pro Leu Val Ala Pro Asp Asn Gly 20 25 30 Ser Ser Arg Ala Leu His Ser Arg Thr Glu Thr Thr Pro Ser Pro Ser 35 40 45 Asn Asp Thr Gly Asn Gly His Pro Glu Tyr Ile Ala Tyr Ala Leu Val 50 55 60 Pro Val Phe Phe Ile Met Gly Leu Phe Gly Val Leu Ile Cys His Leu 65 70 75 80 Leu Lys Lys Lys Gly Tyr Arg Cys Thr Thr Glu Ala Glu Gln Asp Ile 85 90 95 Glu Glu Glu Lys Val Glu Lys Ile Glu Leu Asn Asp Ser Val Asn Glu 100 105 110 Asn Ser Asp Thr Val Gly Gln Ile Val His Tyr Ile Met Lys Asn Glu 115 120 125 Ala Asn Ala Asp Val Leu Lys Ala Met Val Ala Asp Asn Ser Leu Tyr 130 135 140 Asp Pro Glu Ser Pro Val Thr Pro Ser Thr Pro Gly Ser Pro Pro Val 145 150 155 160 Ser Pro Gly Pro Leu Ser Pro Gly Gly Thr Pro Gly Lys His Val Cys 165 170 175 Gly His His Leu His Thr Val Gly Gly Val Val Glu Arg Asp Val Cys 180 185 190 His Arg Cys Arg His Lys Arg Trp His Phe Ile Lys Pro Thr Asn Lys 195 200 205 Ser Arg Glu Ser Arg Pro Arg Arg Gln Gly Glu Val Thr Val Leu Ser 210 215 220 Val Gly Arg Phe Arg Val Thr Lys Val Glu His Lys Ser Asn Gln Lys 225 230 235 240 Glu Arg Arg Ser Leu Met Ser Val Ser Gly Ala Glu Thr Val Asn Gly 245 250 255 Glu Val Pro Ala Thr Pro Val Lys Arg Glu Arg Ser Gly Thr Glu 260 265 270 <210> 181 <211> 2167 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (15)..(1748) <400> 181 aagtagccgc aggc atg gcg gcg gct atg ccg ctt gct ctg ctc gtc ctg 50 Met Ala Ala Ala Met Pro Leu Ala Leu Leu Val Leu 1 5 10 ttg ctc ctg ggg ccc ggc ggc tgg tgc ctt gca gaa ccc cca cgc gac 98 Leu Leu Leu Gly Pro Gly Gly Trp Cys Leu Ala Glu Pro Pro Arg Asp 15 20 25 agc ctg cgg gag gaa ctt gtc atc acc ccg ctg cct tcc ggg gac gta 146 Ser Leu Arg Glu Glu Leu Val Ile Thr Pro Leu Pro Ser Gly Asp Val 30 35 40 gcc gcc aca ttc cag ttc cgc acg cgc tgg gat tcg gag ctt cag cgg 194 Ala Ala Thr Phe Gln Phe Arg Thr Arg Trp Asp Ser Glu Leu Gln Arg 45 50 55 60 gaa gga gtg tcc cat tac agg ctc ttt ccc aaa gcc ctg ggg cag ctg 242 Glu Gly Val Ser His Tyr Arg Leu Phe Pro Lys Ala Leu Gly Gln Leu 65 70 75 atc tcc aag tat tct cta cgg gag ctg cac ctg tca ttc aca caa ggc 290 Ile Ser Lys Tyr Ser Leu Arg Glu Leu His Leu Ser Phe Thr Gln Gly 80 85 90 ttt tgg agg acc cga tac tgg ggg cca ccc ttc ctg cag gcc cca tca 338 Phe Trp Arg Thr Arg Tyr Trp Gly Pro Pro Phe Leu Gln Ala Pro Ser 95 100 105 ggt gca gag ctg tgg gtc tgg ttc caa gac act gtc act gat gtg gat 386 Gly Ala Glu Leu Trp Val Trp Phe Gln Asp Thr Val Thr Asp Val Asp 110 115 120 aaa tct tgg aag gag ctc agt aat gtc ctc tca ggg atc ttc tgc gcc 434 Lys Ser Trp Lys Glu Leu Ser Asn Val Leu Ser Gly Ile Phe Cys Ala 125 130 135 140 tct ctc aac ttc atc gac tcc acc aac aca gtc act ccc act gcc tcc 482 Ser Leu Asn Phe Ile Asp Ser Thr Asn Thr Val Thr Pro Thr Ala Ser 145 150 155 ttc aaa ccc ctg ggt ctg gcc aat gac act gac cac tac ttt ctg cgc 530 Phe Lys Pro Leu Gly Leu Ala Asn Asp Thr Asp His Tyr Phe Leu Arg 160 165 170 tat gct gtg ctg ccg cgg gag gtg gtc tgc acc gaa aac ctc acc ccc 578 Tyr Ala Val Leu Pro Arg Glu Val Val Cys Thr Glu Asn Leu Thr Pro 175 180 185 tgg aag aag ctc ttg ccc tgt agt tcc aag gca ggc ctc tct gtg ctg 626 Trp Lys Lys Leu Leu Pro Cys Ser Ser Lys Ala Gly Leu Ser Val Leu 190 195 200 ctg aag gca gat cgc ttg ttc cac acc agc tac cac tcc cag gca gtg 674 Leu Lys Ala Asp Arg Leu Phe His Thr Ser Tyr His Ser Gln Ala Val 205 210 215 220 cat atc cgc cct gtt tgc aga aat gca cgc tgt act agc atc tcc tgg 722 His Ile Arg Pro Val Cys Arg Asn Ala Arg Cys Thr Ser Ile Ser Trp 225 230 235 gag ctg agg cag acc ctg tca gtt gta ttt gat gcc ttc atc acg ggg 770 Glu Leu Arg Gln Thr Leu Ser Val Val Phe Asp Ala Phe Ile Thr Gly 240 245 250 cag gga aag aaa gac tgg tcc ctc ttc cgg atg ttc tcc cga acc ctc 818 Gln Gly Lys Lys Asp Trp Ser Leu Phe Arg Met Phe Ser Arg Thr Leu 255 260 265 acg gag ccc tgc ccc ctg gct tca gag agc cga gtc tat gtg gac atc 866 Thr Glu Pro Cys Pro Leu Ala Ser Glu Ser Arg Val Tyr Val Asp Ile 270 275 280 acc acc tac aac cag gac aac gag aca tta gag gtg cac cca ccc ccg 914 Thr Thr Tyr Asn Gln Asp Asn Glu Thr Leu Glu Val His Pro Pro Pro 285 290 295 300 acc act aca tat cag gac gtc atc cta ggc act cgg aag acc tat gcc 962 Thr Thr Thr Tyr Gln Asp Val Ile Leu Gly Thr Arg Lys Thr Tyr Ala 305 310 315 atc tat gac ttg ctt gac acc gcc atg atc aac aac tct cga aac ctc 1010 Ile Tyr Asp Leu Leu Asp Thr Ala Met Ile Asn Asn Ser Arg Asn Leu 320 325 330 aac atc cag ctc aag tgg aag aga ccc cca gag aat gag gcc ccc cca 1058 Asn Ile Gln Leu Lys Trp Lys Arg Pro Pro Glu Asn Glu Ala Pro Pro 335 340 345 gtg ccc ttc ctg cat gcc cag cgg tac gtg agt ggc tat ggg ctg cag 1106 Val Pro Phe Leu His Ala Gln Arg Tyr Val Ser Gly Tyr Gly Leu Gln 350 355 360 aag ggg gag ctg agc aca ctg ctg tac aac acc cac cca tac cgg gcc 1154 Lys Gly Glu Leu Ser Thr Leu Leu Tyr Asn Thr His Pro Tyr Arg Ala 365 370 375 380 ttc ccg gtg ctg ctg ctg gac acc gta ccc tgg tat ctg cgg ctg tat 1202 Phe Pro Val Leu Leu Leu Asp Thr Val Pro Trp Tyr Leu Arg Leu Tyr 385 390 395 gtg cac acc ctc acc atc acc tcc aag ggc aag gag aac aaa cca agt 1250 Val His Thr Leu Thr Ile Thr Ser Lys Gly Lys Glu Asn Lys Pro Ser 400 405 410 tac atc cac tac cag cct gcc cag gac cgg ctg caa ccc cac ctc ctg 1298 Tyr Ile His Tyr Gln Pro Ala Gln Asp Arg Leu Gln Pro His Leu Leu 415 420 425 gag atg ctg att cag ctg ccg gcc aac tca gtc acc aag gtt tcc atc 1346 Glu Met Leu Ile Gln Leu Pro Ala Asn Ser Val Thr Lys Val Ser Ile 430 435 440 cag ttt gag cgg gcg ctg ctg aag tgg acc gag tac acg cca gat cct 1394 Gln Phe Glu Arg Ala Leu Leu Lys Trp Thr Glu Tyr Thr Pro Asp Pro 445 450 455 460 aac cat ggc ttc tat gtc agc cca tct gtc ctc agc gcc ctt gtg ccc 1442 Asn His Gly Phe Tyr Val Ser Pro Ser Val Leu Ser Ala Leu Val Pro 465 470 475 agc atg gta gca gcc aag cca gtg gac tgg gaa gag agt ccc ctc ttc 1490 Ser Met Val Ala Ala Lys Pro Val Asp Trp Glu Glu Ser Pro Leu Phe 480 485 490 aac agc ctg ttc cca gtc tct gat ggc tct aac tac ttt gtg cgg ctc 1538 Asn Ser Leu Phe Pro Val Ser Asp Gly Ser Asn Tyr Phe Val Arg Leu 495 500 505 tac acg gag ccg ctg ctg gtg aac ctg ccg aca ccg gac ttc agc atg 1586 Tyr Thr Glu Pro Leu Leu Val Asn Leu Pro Thr Pro Asp Phe Ser Met 510 515 520 ccc tac aac gtg atc tgc ctc acg tgc act gtg gtg gcc gtg tgc tat 1634 Pro Tyr Asn Val Ile Cys Leu Thr Cys Thr Val Val Ala Val Cys Tyr 525 530 535 540 ggc tcc ttc tac aat ctc ctc acc cga acc ttc cac atc gag gag ccc 1682 Gly Ser Phe Tyr Asn Leu Leu Thr Arg Thr Phe His Ile Glu Glu Pro 545 550 555 cgc aca ggt ggc ctg gcc aag cgg ctg gcc aac ctt atc cgg cgc gcc 1730 Arg Thr Gly Gly Leu Ala Lys Arg Leu Ala Asn Leu Ile Arg Arg Ala 560 565 570 cga ggt gtc ccc cca ctc tgattcttgc cctttccagc agctgcagct 1778 Arg Gly Val Pro Pro Leu 575 gccgtttctc tctggggagg ggagcccaag ggctgtttct gccacttgct ctcctcagag 1838 ttggcttttg aaccaaagtg ccctggacca ggtcagggcc tacagctgtg ttgtccagta 1898 caggagccac gagccaaatg tggcatttga atttgaatta acttagaaat tcatttcctc 1958 acctgtagtg gccacctcta tattgaggtg ctcaataagc aaaagtggtc ggtggctgct 2018 gtattggaca gcacagaaaa agatttccat caccacagaa aggtcggctg gcagcactgg 2078 ccaaggtgat ggggtgtgct acacagtgta tgtcactgtg tagtggatgg agtttactgt 2138 ttgtggaata aaaacggctg tttccgtgg 2167 <210> 182 <211> 578 <212> PRT <213> Homo sapiens <400> 182 Met Ala Ala Ala Met Pro Leu Ala Leu Leu Val Leu Leu Leu Leu Gly 1 5 10 15 Pro Gly Gly Trp Cys Leu Ala Glu Pro Pro Arg Asp Ser Leu Arg Glu 20 25 30 Glu Leu Val Ile Thr Pro Leu Pro Ser Gly Asp Val Ala Ala Thr Phe 35 40 45 Gln Phe Arg Thr Arg Trp Asp Ser Glu Leu Gln Arg Glu Gly Val Ser 50 55 60 His Tyr Arg Leu Phe Pro Lys Ala Leu Gly Gln Leu Ile Ser Lys Tyr 65 70 75 80 Ser Leu Arg Glu Leu His Leu Ser Phe Thr Gln Gly Phe Trp Arg Thr 85 90 95 Arg Tyr Trp Gly Pro Pro Phe Leu Gln Ala Pro Ser Gly Ala Glu Leu 100 105 110 Trp Val Trp Phe Gln Asp Thr Val Thr Asp Val Asp Lys Ser Trp Lys 115 120 125 Glu Leu Ser Asn Val Leu Ser Gly Ile Phe Cys Ala Ser Leu Asn Phe 130 135 140 Ile Asp Ser Thr Asn Thr Val Thr Pro Thr Ala Ser Phe Lys Pro Leu 145 150 155 160 Gly Leu Ala Asn Asp Thr Asp His Tyr Phe Leu Arg Tyr Ala Val Leu 165 170 175 Pro Arg Glu Val Val Cys Thr Glu Asn Leu Thr Pro Trp Lys Lys Leu 180 185 190 Leu Pro Cys Ser Ser Lys Ala Gly Leu Ser Val Leu Leu Lys Ala Asp 195 200 205 Arg Leu Phe His Thr Ser Tyr His Ser Gln Ala Val His Ile Arg Pro 210 215 220 Val Cys Arg Asn Ala Arg Cys Thr Ser Ile Ser Trp Glu Leu Arg Gln 225 230 235 240 Thr Leu Ser Val Val Phe Asp Ala Phe Ile Thr Gly Gln Gly Lys Lys 245 250 255 Asp Trp Ser Leu Phe Arg Met Phe Ser Arg Thr Leu Thr Glu Pro Cys 260 265 270 Pro Leu Ala Ser Glu Ser Arg Val Tyr Val Asp Ile Thr Thr Tyr Asn 275 280 285 Gln Asp Asn Glu Thr Leu Glu Val His Pro Pro Pro Thr Thr Thr Tyr 290 295 300 Gln Asp Val Ile Leu Gly Thr Arg Lys Thr Tyr Ala Ile Tyr Asp Leu 305 310 315 320 Leu Asp Thr Ala Met Ile Asn Asn Ser Arg Asn Leu Asn Ile Gln Leu 325 330 335 Lys Trp Lys Arg Pro Pro Glu Asn Glu Ala Pro Pro Val Pro Phe Leu 340 345 350 His Ala Gln Arg Tyr Val Ser Gly Tyr Gly Leu Gln Lys Gly Glu Leu 355 360 365 Ser Thr Leu Leu Tyr Asn Thr His Pro Tyr Arg Ala Phe Pro Val Leu 370 375 380 Leu Leu Asp Thr Val Pro Trp Tyr Leu Arg Leu Tyr Val His Thr Leu 385 390 395 400 Thr Ile Thr Ser Lys Gly Lys Glu Asn Lys Pro Ser Tyr Ile His Tyr 405 410 415 Gln Pro Ala Gln Asp Arg Leu Gln Pro His Leu Leu Glu Met Leu Ile 420 425 430 Gln Leu Pro Ala Asn Ser Val Thr Lys Val Ser Ile Gln Phe Glu Arg 435 440 445 Ala Leu Leu Lys Trp Thr Glu Tyr Thr Pro Asp Pro Asn His Gly Phe 450 455 460 Tyr Val Ser Pro Ser Val Leu Ser Ala Leu Val Pro Ser Met Val Ala 465 470 475 480 Ala Lys Pro Val Asp Trp Glu Glu Ser Pro Leu Phe Asn Ser Leu Phe 485 490 495 Pro Val Ser Asp Gly Ser Asn Tyr Phe Val Arg Leu Tyr Thr Glu Pro 500 505 510 Leu Leu Val Asn Leu Pro Thr Pro Asp Phe Ser Met Pro Tyr Asn Val 515 520 525 Ile Cys Leu Thr Cys Thr Val Val Ala Val Cys Tyr Gly Ser Phe Tyr 530 535 540 Asn Leu Leu Thr Arg Thr Phe His Ile Glu Glu Pro Arg Thr Gly Gly 545 550 555 560 Leu Ala Lys Arg Leu Ala Asn Leu Ile Arg Arg Ala Arg Gly Val Pro 565 570 575 Pro Leu <210> 183 <211> 1877 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (24)..(1412) <400> 183 agaaggagag acggctggcc acc atg cac ggc tcc tgc agt ttc ctg atg ctt 53 Met His Gly Ser Cys Ser Phe Leu Met Leu 1 5 10 ctg ctg ccg cta ctg cta ctg ctg gtg gcc acc aca ggc ccc gtt gga 101 Leu Leu Pro Leu Leu Leu Leu Leu Val Ala Thr Thr Gly Pro Val Gly 15 20 25 gcc ctc aca gat gag gag aaa cgt ttg atg gtg gag ctg cac aac ctc 149 Ala Leu Thr Asp Glu Glu Lys Arg Leu Met Val Glu Leu His Asn Leu 30 35 40 tac cgg gcc cag gta tcc ccg ccg gcc tca gac atg ctg cac atg aga 197 Tyr Arg Ala Gln Val Ser Pro Pro Ala Ser Asp Met Leu His Met Arg 45 50 55 tgg gac gag gag ctg gcc gcc ttc gcc aag gcc tac gca cgg cag tgc 245 Trp Asp Glu Glu Leu Ala Ala Phe Ala Lys Ala Tyr Ala Arg Gln Cys 60 65 70 gtg tgg ggc cac aac aag gag cgc ggg cgc cgc ggc gag aat ctg ttc 293 Val Trp Gly His Asn Lys Glu Arg Gly Arg Arg Gly Glu Asn Leu Phe 75 80 85 90 gcc atc aca gac gag ggc atg gac gtg ccg ctg gcc atg gag gag tgg 341 Ala Ile Thr Asp Glu Gly Met Asp Val Pro Leu Ala Met Glu Glu Trp 95 100 105 cac cac gag cgt gag cac tac aac ctc agc gcc gcc acc tgc agc cca 389 His His Glu Arg Glu His Tyr Asn Leu Ser Ala Ala Thr Cys Ser Pro 110 115 120 ggc cag atg tgc ggc cac tac acg cag gtg gta tgg gcc aag aca gag 437 Gly Gln Met Cys Gly His Tyr Thr Gln Val Val Trp Ala Lys Thr Glu 125 130 135 agg atc ggc tgt ggt tcc cac ttc tgt gag aag ctc cag ggt gtt gag 485 Arg Ile Gly Cys Gly Ser His Phe Cys Glu Lys Leu Gln Gly Val Glu 140 145 150 gag acc aac atc gaa tta ctg gtg tgc aac tat gag cct ccg ggg aac 533 Glu Thr Asn Ile Glu Leu Leu Val Cys Asn Tyr Glu Pro Pro Gly Asn 155 160 165 170 gtg aag ggg aaa cgg ccc tac cag ggg ggg act ccg tgc tcc caa tgt 581 Val Lys Gly Lys Arg Pro Tyr Gln Gly Gly Thr Pro Cys Ser Gln Cys 175 180 185 ccc tct ggc tac cac tgc aag aac tcc ctc tgt gaa ccc atc gga agc 629 Pro Ser Gly Tyr His Cys Lys Asn Ser Leu Cys Glu Pro Ile Gly Ser 190 195 200 ccg gaa gat gct cag gat ttg cct tac ctg gta act gag gcc cca tcc 677 Pro Glu Asp Ala Gln Asp Leu Pro Tyr Leu Val Thr Glu Ala Pro Ser 205 210 215 ttc cgg gcg act gaa gca tca gac tct agg aaa atg ggt act cct tct 725 Phe Arg Ala Thr Glu Ala Ser Asp Ser Arg Lys Met Gly Thr Pro Ser 220 225 230 tcc cta gca acg ggg att ccg gct ttc ttg gta aca gag gtc tca ggc 773 Ser Leu Ala Thr Gly Ile Pro Ala Phe Leu Val Thr Glu Val Ser Gly 235 240 245 250 tcc ctg gca acc aag gct ctg cct gct gtg gaa acc cag gcc cca act 821 Ser Leu Ala Thr Lys Ala Leu Pro Ala Val Glu Thr Gln Ala Pro Thr 255 260 265 tcc tta gca acg aag gac ccg ccc tcc atg gca aca gag gct cca cct 869 Ser Leu Ala Thr Lys Asp Pro Pro Ser Met Ala Thr Glu Ala Pro Pro 270 275 280 tgc gta aca act gag gcc cct tcc att ttg gca gct cac agc ctg ccc 917 Cys Val Thr Thr Glu Ala Pro Ser Ile Leu Ala Ala His Ser Leu Pro 285 290 295 tcc ttg gat gag gag cca gtt acc ttc ccc aaa tcg acc cat gtt cct 965 Ser Leu Asp Glu Glu Pro Val Thr Phe Pro Lys Ser Thr His Val Pro 300 305 310 atc cca aaa tca gca gac aaa gtg aca gac aaa aca aaa gtg ccc tct 1013 Ile Pro Lys Ser Ala Asp Lys Val Thr Asp Lys Thr Lys Val Pro Ser 315 320 325 330 agg agc cca gag aac tct ctg gac ccc aag atg tcc ctg aca ggg gca 1061 Arg Ser Pro Glu Asn Ser Leu Asp Pro Lys Met Ser Leu Thr Gly Ala 335 340 345 agg gag ctc cta ccc cat gcc cag gag gag gct gag gct gag gct gag 1109 Arg Glu Leu Leu Pro His Ala Gln Glu Glu Ala Glu Ala Glu Ala Glu 350 355 360 ttg cct cct tcc agt gag gtc ttg gcc tca gtt ttt cca gcc cag gac 1157 Leu Pro Pro Ser Ser Glu Val Leu Ala Ser Val Phe Pro Ala Gln Asp 365 370 375 aag cca ggt gag ctg cag gcc aca ctg gac cac acg ggg cac acc tcc 1205 Lys Pro Gly Glu Leu Gln Ala Thr Leu Asp His Thr Gly His Thr Ser 380 385 390 tcc aag tcc ctg ccc aat ttc ccc aat acc tct gcc acc gct aat gcc 1253 Ser Lys Ser Leu Pro Asn Phe Pro Asn Thr Ser Ala Thr Ala Asn Ala 395 400 405 410 acg ggt ggg cgt gcc ctg gct ctg cag tcg tcc ttg cca ggt gca gag 1301 Thr Gly Gly Arg Ala Leu Ala Leu Gln Ser Ser Leu Pro Gly Ala Glu 415 420 425 ggc cct gac aag cct agc gtc gtg tca ggg ctg aac tcg ggc cct ggt 1349 Gly Pro Asp Lys Pro Ser Val Val Ser Gly Leu Asn Ser Gly Pro Gly 430 435 440 cat gtg tgg ggc cct ctc ctg gga cta ctg ctc ctg cct cct ctg gtg 1397 His Val Trp Gly Pro Leu Leu Gly Leu Leu Leu Leu Pro Pro Leu Val 445 450 455 ttg gct gga atc ttc tgaaggggat accactcaaa gggtgaagag gtcagctgtc 1452 Leu Ala Gly Ile Phe 460 ctcctgtcat cttccccacc ctgtccccag cccctaaaca agatacttct tggttaaggc 1512 cctccggaag ggaaaggcta cggggcatgt gcctcatcac accatccatc ctggaggcac 1572 aaggcctggc tggctgcgag ctcaggaggc cgcctgagga ctgcacaccg ggcccacacc 1632 tctcctgccc ctccctcctg agtcctgggg gtgggaggat ttgagggagc tcactgccta 1692 cctggcctgg ggctgtctgc ccacacagca tgtgcgctct ccctgagtgc ctgtgtagct 1752 ggggatgggg attcctaggg gcagatgaag gacaagcccc actggagtgg ggttctttga 1812 gtgggggagg cagggacgag ggaaggaaag taactcctga ctctccaata aaaacctgtc 1872 caacc 1877 <210> 184 <211> 463 <212> PRT <213> Homo sapiens <400> 184 Met His Gly Ser Cys Ser Phe Leu Met Leu Leu Leu Pro Leu Leu Leu 1 5 10 15 Leu Leu Val Ala Thr Thr Gly Pro Val Gly Ala Leu Thr Asp Glu Glu 20 25 30 Lys Arg Leu Met Val Glu Leu His Asn Leu Tyr Arg Ala Gln Val Ser 35 40 45 Pro Pro Ala Ser Asp Met Leu His Met Arg Trp Asp Glu Glu Leu Ala 50 55 60 Ala Phe Ala Lys Ala Tyr Ala Arg Gln Cys Val Trp Gly His Asn Lys 65 70 75 80 Glu Arg Gly Arg Arg Gly Glu Asn Leu Phe Ala Ile Thr Asp Glu Gly 85 90 95 Met Asp Val Pro Leu Ala Met Glu Glu Trp His His Glu Arg Glu His 100 105 110 Tyr Asn Leu Ser Ala Ala Thr Cys Ser Pro Gly Gln Met Cys Gly His 115 120 125 Tyr Thr Gln Val Val Trp Ala Lys Thr Glu Arg Ile Gly Cys Gly Ser 130 135 140 His Phe Cys Glu Lys Leu Gln Gly Val Glu Glu Thr Asn Ile Glu Leu 145 150 155 160 Leu Val Cys Asn Tyr Glu Pro Pro Gly Asn Val Lys Gly Lys Arg Pro 165 170 175 Tyr Gln Gly Gly Thr Pro Cys Ser Gln Cys Pro Ser Gly Tyr His Cys 180 185 190 Lys Asn Ser Leu Cys Glu Pro Ile Gly Ser Pro Glu Asp Ala Gln Asp 195 200 205 Leu Pro Tyr Leu Val Thr Glu Ala Pro Ser Phe Arg Ala Thr Glu Ala 210 215 220 Ser Asp Ser Arg Lys Met Gly Thr Pro Ser Ser Leu Ala Thr Gly Ile 225 230 235 240 Pro Ala Phe Leu Val Thr Glu Val Ser Gly Ser Leu Ala Thr Lys Ala 245 250 255 Leu Pro Ala Val Glu Thr Gln Ala Pro Thr Ser Leu Ala Thr Lys Asp 260 265 270 Pro Pro Ser Met Ala Thr Glu Ala Pro Pro Cys Val Thr Thr Glu Ala 275 280 285 Pro Ser Ile Leu Ala Ala His Ser Leu Pro Ser Leu Asp Glu Glu Pro 290 295 300 Val Thr Phe Pro Lys Ser Thr His Val Pro Ile Pro Lys Ser Ala Asp 305 310 315 320 Lys Val Thr Asp Lys Thr Lys Val Pro Ser Arg Ser Pro Glu Asn Ser 325 330 335 Leu Asp Pro Lys Met Ser Leu Thr Gly Ala Arg Glu Leu Leu Pro His 340 345 350 Ala Gln Glu Glu Ala Glu Ala Glu Ala Glu Leu Pro Pro Ser Ser Glu 355 360 365 Val Leu Ala Ser Val Phe Pro Ala Gln Asp Lys Pro Gly Glu Leu Gln 370 375 380 Ala Thr Leu Asp His Thr Gly His Thr Ser Ser Lys Ser Leu Pro Asn 385 390 395 400 Phe Pro Asn Thr Ser Ala Thr Ala Asn Ala Thr Gly Gly Arg Ala Leu 405 410 415 Ala Leu Gln Ser Ser Leu Pro Gly Ala Glu Gly Pro Asp Lys Pro Ser 420 425 430 Val Val Ser Gly Leu Asn Ser Gly Pro Gly His Val Trp Gly Pro Leu 435 440 445 Leu Gly Leu Leu Leu Leu Pro Pro Leu Val Leu Ala Gly Ile Phe 450 455 460 <210> 185 <211> 2111 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4)..(729) <400> 185 tgc atg ctg aag ctc tac cgg aag cgg cac ccg gac atc aac gcc agc 48 Met Leu Lys Leu Tyr Arg Lys Arg His Pro Asp Ile Asn Ala Ser 1 5 10 15 gcc tac agt gcc tac gcc tgc ctg gcc att gtc atc ttc ttc tct gtg 96 Ala Tyr Ser Ala Tyr Ala Cys Leu Ala Ile Val Ile Phe Phe Ser Val 20 25 30 ctg ggc gtg gtc ttt ggc aaa ggg aac acg gcg ttc tgg atc gtc ttc 144 Leu Gly Val Val Phe Gly Lys Gly Asn Thr Ala Phe Trp Ile Val Phe 35 40 45 tcc atc att cac atc atc gcc acc ctg ctc ctc agc acg cag ctc tat 192 Ser Ile Ile His Ile Ile Ala Thr Leu Leu Leu Ser Thr Gln Leu Tyr 50 55 60 tac atg ggc cgg tgg aaa ctg gac tcg ggg atc ttc cgc cgc atc ctc 240 Tyr Met Gly Arg Trp Lys Leu Asp Ser Gly Ile Phe Arg Arg Ile Leu 65 70 75 cac gtg ctc tac aca gac tgc atc cgg cag tgc agc ggg ccg ctc tac 288 His Val Leu Tyr Thr Asp Cys Ile Arg Gln Cys Ser Gly Pro Leu Tyr 80 85 90 95 gtg gac cgc atg gtg ctg ctg gtc atg ggc aac gtc atc aac tgg tcg 336 Val Asp Arg Met Val Leu Leu Val Met Gly Asn Val Ile Asn Trp Ser 100 105 110 ctg gct gcc tat ggg ctt atc atg cgc ccc aat gat ttc gct tcc tac 384 Leu Ala Ala Tyr Gly Leu Ile Met Arg Pro Asn Asp Phe Ala Ser Tyr 115 120 125 ttg ttg gcc att ggc atc tgc aac ctg ctc ctt tac ttc gcc ttc tac 432 Leu Leu Ala Ile Gly Ile Cys Asn Leu Leu Leu Tyr Phe Ala Phe Tyr 130 135 140 atc atc atg aag ctc cgg agt ggg gag agg atc aag ctc atc ccc ctg 480 Ile Ile Met Lys Leu Arg Ser Gly Glu Arg Ile Lys Leu Ile Pro Leu 145 150 155 ctc tgc atc gtt tgc acc tcc gtg gtc tgg ggc ttc gcg ctc ttc ttc 528 Leu Cys Ile Val Cys Thr Ser Val Val Trp Gly Phe Ala Leu Phe Phe 160 165 170 175 ttc ttc cag gga ctc agc acc tgg cag aaa acc cct gca gag tcg agg 576 Phe Phe Gln Gly Leu Ser Thr Trp Gln Lys Thr Pro Ala Glu Ser Arg 180 185 190 gag cac aac cgg gac tgc atc ctc ctc gac ttc ttt aac gac cac gac 624 Glu His Asn Arg Asp Cys Ile Leu Leu Asp Phe Phe Asn Asp His Asp 195 200 205 atc tgg cac ttc ctc tcc tcc atc gcc atg ttc ggg tcc ttc ctg gtg 672 Ile Trp His Phe Leu Ser Ser Ile Ala Met Phe Gly Ser Phe Leu Val 210 215 220 ttg ctg aca ctg gat gac gac ctg gat act gtg cag cgg gac aag atc 720 Leu Leu Thr Leu Asp Asp Asp Leu Asp Thr Val Gln Arg Asp Lys Ile 225 230 235 tat gtc ttc tagcaggagc tgggcccttc gcttcacctc aaggggccct 769 Tyr Val Phe 240 gagctccttt gtgtcataga ccggtcactc tgtcgtgctg tggggatgag tcccagcacc 829 gctgcccagc actggatggc agcaggacag ccaggtctag cttaggcttg gcctgggaca 889 gccatggggt ggcatggaac cttgcggctg ccctctgccg aggagcaggc ctgctcccct 949 ggaaccccca gatgttggcc aaattgctgc tttcttctca gtgttggggc cttccatggg 1009 cccctgtcct ttggctctcc atttgtccct ttgcaagagg aaggatggaa gggacaccct 1069 ccccatttca tgccttgcat tttgcccgtc ctcctcccca caatgcccca gcctgggacc 1129 taaggcctct ttttcctccc atactcccac tccagggcct agtctggggc ctgaatctct 1189 gtcctgtatc agggccccag ttctctttgg gctgtccctg gctgccatca ctgcccattc 1249 cagtcagcca ggatggatgg gggtatgaga ttttgggggt tggccagctg gtgccagact 1309 tttggtgcta aggcctgcaa ggggcctggg gcagtgcgta ttctcttccc tctgacctgt 1369 gctcagggct ggctctttag caatgcgctc agcccaattt gagaaccgcc ttctgattca 1429 agaggctgaa ttcagaggtc acctcttcat cccatcagct cccagactga tgccagcacc 1489 aggactggag ggagaagcgc ctcacccctt cccttccttc tttccaggcc cttagtcttg 1549 ccaaacccca gctggtggcc tttcagtgcc attgacactg cccaagaatg tccaggggca 1609 aaggagggat gatacagagt tcagcccgtt ctgcctccac agctgtgggc accccagtgc 1669 ctaccttaga aaagggcttc aggaagggat gtgctgtttc cctctacgtg cccagtccta 1729 gcctcgctct aggacccagg gctggcttct aagtttccgt ccagtcttca ggcaagttct 1789 gtgttagtca tgcacacaca tacctatgaa accttggagt ttacaaagaa ttgccccagc 1849 tctgggcacc ctggccaccc tggtccttgg atccccttcg tcccacctgg tccaccccag 1909 atgctgagga tgggggagct caggcggggc ctctgctttg gggatgggaa tgtgtttttc 1969 tcccaaactt gtttttatag ctctgcttga agggctggga gatgaggtgg gtctggatct 2029 tttctcagag cgtctccatg ctatggttgc atttccgttt tctatgaatg aatttgcatt 2089 caataaacaa ccagactcag tt 2111 <210> 186 <211> 242 <212> PRT <213> Homo sapiens <400> 186 Met Leu Lys Leu Tyr Arg Lys Arg His Pro Asp Ile Asn Ala Ser Ala 1 5 10 15 Tyr Ser Ala Tyr Ala Cys Leu Ala Ile Val Ile Phe Phe Ser Val Leu 20 25 30 Gly Val Val Phe Gly Lys Gly Asn Thr Ala Phe Trp Ile Val Phe Ser 35 40 45 Ile Ile His Ile Ile Ala Thr Leu Leu Leu Ser Thr Gln Leu Tyr Tyr 50 55 60 Met Gly Arg Trp Lys Leu Asp Ser Gly Ile Phe Arg Arg Ile Leu His 65 70 75 80 Val Leu Tyr Thr Asp Cys Ile Arg Gln Cys Ser Gly Pro Leu Tyr Val 85 90 95 Asp Arg Met Val Leu Leu Val Met Gly Asn Val Ile Asn Trp Ser Leu 100 105 110 Ala Ala Tyr Gly Leu Ile Met Arg Pro Asn Asp Phe Ala Ser Tyr Leu 115 120 125 Leu Ala Ile Gly Ile Cys Asn Leu Leu Leu Tyr Phe Ala Phe Tyr Ile 130 135 140 Ile Met Lys Leu Arg Ser Gly Glu Arg Ile Lys Leu Ile Pro Leu Leu 145 150 155 160 Cys Ile Val Cys Thr Ser Val Val Trp Gly Phe Ala Leu Phe Phe Phe 165 170 175 Phe Gln Gly Leu Ser Thr Trp Gln Lys Thr Pro Ala Glu Ser Arg Glu 180 185 190 His Asn Arg Asp Cys Ile Leu Leu Asp Phe Phe Asn Asp His Asp Ile 195 200 205 Trp His Phe Leu Ser Ser Ile Ala Met Phe Gly Ser Phe Leu Val Leu 210 215 220 Leu Thr Leu Asp Asp Asp Leu Asp Thr Val Gln Arg Asp Lys Ile Tyr 225 230 235 240 Val Phe <210> 187 <211> 874 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (335)..(643) <400> 187 aggtgtgtgc agggggtggg tgtgttagcg tgggttaggg gaacgtgtgt gcgcgtgctg 60 gtgggcatgt gagatgagtg actgccggtg aatgtgtcca cagttgagag gttggagcag 120 gatgagggaa tcctgtcacc atcaataatc acttgtggag cgccagctct gcccaaggcg 180 ccacctgggc ggacagccag gaactctcca tggccaggct gcctgtgtgc atgttccctg 240 tctggtgccc ctttgcccgc ctcctgcaaa cctcacaggg tccccacaca acagtgccct 300 ccagaagcag cccctcggag gcagaggaag gaaa atg ggg atg gct ggg gct ctc 355 Met Gly Met Ala Gly Ala Leu 1 5 tcc atc ctc ctt ttc tcc ttg cct tcg cat ggc tgg cct tcc cct cca 403 Ser Ile Leu Leu Phe Ser Leu Pro Ser His Gly Trp Pro Ser Pro Pro 10 15 20 aaa cct cca ttc ccc tgc tgc cag ccc ctt tgc cat agc ctg att ttg 451 Lys Pro Pro Phe Pro Cys Cys Gln Pro Leu Cys His Ser Leu Ile Leu 25 30 35 ggg agg agg aag ggg cga ttt gag gga gaa ggg gag aaa gct tat ggc 499 Gly Arg Arg Lys Gly Arg Phe Glu Gly Glu Gly Glu Lys Ala Tyr Gly 40 45 50 55 tgg gtc tgg ttt ctt ccc ttc cca gag ggt ctt act gtt cca ggg tgg 547 Trp Val Trp Phe Leu Pro Phe Pro Glu Gly Leu Thr Val Pro Gly Trp 60 65 70 ccc cag ggc agg cag ggg cca cac tat gcc tgc gcc ctg gta aag gtg 595 Pro Gln Gly Arg Gln Gly Pro His Tyr Ala Cys Ala Leu Val Lys Val 75 80 85 acc cct gcc att tac cag cag ccc tgg cat gtt cct gcc cca cag gaa 643 Thr Pro Ala Ile Tyr Gln Gln Pro Trp His Val Pro Ala Pro Gln Glu 90 95 100 tagaatggag ggagctccag aaactttcca tcccaaaggc agtctccgtg gttgaagcag 703 actggatttt tgttctgccc ctgacccctt gtccctcttt gagggagggg agctatgcta 763 ggactccaac ctcagggact cgggtggcct gcgctagctt cttttgatac tgaaaacttt 823 taaggtggga gggtggcaag ggatgtgctt aataaatcaa ttccaagcct c 874 <210> 188 <211> 103 <212> PRT <213> Homo sapiens <400> 188 Met Gly Met Ala Gly Ala Leu Ser Ile Leu Leu Phe Ser Leu Pro Ser 1 5 10 15 His Gly Trp Pro Ser Pro Pro Lys Pro Pro Phe Pro Cys Cys Gln Pro 20 25 30 Leu Cys His Ser Leu Ile Leu Gly Arg Arg Lys Gly Arg Phe Glu Gly 35 40 45 Glu Gly Glu Lys Ala Tyr Gly Trp Val Trp Phe Leu Pro Phe Pro Glu 50 55 60 Gly Leu Thr Val Pro Gly Trp Pro Gln Gly Arg Gln Gly Pro His Tyr 65 70 75 80 Ala Cys Ala Leu Val Lys Val Thr Pro Ala Ile Tyr Gln Gln Pro Trp 85 90 95 His Val Pro Ala Pro Gln Glu 100 <210> 189 <211> 2533 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (44)..(850) <400> 189 atactcctaa gctcctcccc cggcggcgag ccagggagaa agg atg gcc ggc ctg 55 Met Ala Gly Leu 1 gcg gcg cgg ttg gtc ctg cta gct ggg gca gcg gcg ctg gcg agc ggc 103 Ala Ala Arg Leu Val Leu Leu Ala Gly Ala Ala Ala Leu Ala Ser Gly 5 10 15 20 tcc cag ggc gac cgt gag ccg gtg tac cgc gac tgc gta ctg cag tgc 151 Ser Gln Gly Asp Arg Glu Pro Val Tyr Arg Asp Cys Val Leu Gln Cys 25 30 35 gaa gag cag aat tgc tct ggg ggc gct ctg aat cac ttc cgc tcc cgc 199 Glu Glu Gln Asn Cys Ser Gly Gly Ala Leu Asn His Phe Arg Ser Arg 40 45 50 cag cca atc tac atg agt cta gca ggc tgg acc tgt cgg gac gac tgt 247 Gln Pro Ile Tyr Met Ser Leu Ala Gly Trp Thr Cys Arg Asp Asp Cys 55 60 65 aag tat gag tgt atg tgg gtc acc gtt ggg ctc tac ctc cag gaa ggt 295 Lys Tyr Glu Cys Met Trp Val Thr Val Gly Leu Tyr Leu Gln Glu Gly 70 75 80 cac aaa gtg cct cag ttc cat ggc aag gtg tcc ctc aat gca tgg ttc 343 His Lys Val Pro Gln Phe His Gly Lys Val Ser Leu Asn Ala Trp Phe 85 90 95 100 tgg ccc aca gtt ttc cac acc agg gac act gac ctc aca gag aaa atg 391 Trp Pro Thr Val Phe His Thr Arg Asp Thr Asp Leu Thr Glu Lys Met 105 110 115 gac tac ttc tgt gcc tcc act gtc atc cta cac tca atc tac ctg tgc 439 Asp Tyr Phe Cys Ala Ser Thr Val Ile Leu His Ser Ile Tyr Leu Cys 120 125 130 tgc gtc agg acc gtg ggg ctg cag cac cca gct gtg gtc agt gcc ttc 487 Cys Val Arg Thr Val Gly Leu Gln His Pro Ala Val Val Ser Ala Phe 135 140 145 cgg gct ctc ctg ctg ctc atg ctg acc gtg cac gtc tcc tac ctg agc 535 Arg Ala Leu Leu Leu Leu Met Leu Thr Val His Val Ser Tyr Leu Ser 150 155 160 ctc atc cgc ttc gac tat ggc tac aac ctg gtg gcc aac gtg gct att 583 Leu Ile Arg Phe Asp Tyr Gly Tyr Asn Leu Val Ala Asn Val Ala Ile 165 170 175 180 ggc ctg gtc aac gtg gtg tgg tgg ctg gcc tgg tgc ctg tgg aac cag 631 Gly Leu Val Asn Val Val Trp Trp Leu Ala Trp Cys Leu Trp Asn Gln 185 190 195 cgg cgg ctg cct cac gtg cgc aag cgc gtg gtg gtg gtc ttg ctg ctg 679 Arg Arg Leu Pro His Val Arg Lys Arg Val Val Val Val Leu Leu Leu 200 205 210 cag ggg ctg tcc ctg ctc gag ctg ctt gac ttc cca ccg ctc ttc tgg 727 Gln Gly Leu Ser Leu Leu Glu Leu Leu Asp Phe Pro Pro Leu Phe Trp 215 220 225 gtc ctg gat gcc cat gcc atc tgg cac atc agc acc atc cct gtc cac 775 Val Leu Asp Ala His Ala Ile Trp His Ile Ser Thr Ile Pro Val His 230 235 240 gtc ctc ttt ttc agc ttt ctg gaa gat gac agc ctg tac ctg ctg aag 823 Val Leu Phe Phe Ser Phe Leu Glu Asp Asp Ser Leu Tyr Leu Leu Lys 245 250 255 260 gaa tca gag gac aag ttc aag ctg gac tgaagacctt ggagcgagtc 870 Glu Ser Glu Asp Lys Phe Lys Leu Asp 265 tgccccagtg gggatcctgc ccccgccctg ctggcctccc ttctcccctc aacccttgag 930 atgattttct cttttcaact tcttgaactt ggacatgaag gatgtgggcc cagaatcatg 990 tggccagccc accccctgtt ggccctcacc agccttggag tctgttctag ggaaggcctc 1050 ccagcatctg ggactcgaga gtgggcagcc cctctacctc ctggagctga actggggtgg 1110 aactgagtgt gctcttagct ctaccgggag gacagctgcc tgtttcctcc ccatcagcct 1170 cctccccaca tccccagctg cctggctggg tcctgaagcc ctctgtctac ctgggagacc 1230 agggaccaca ggccttaggg atacaggggg tccccttctg ttaccacccc ccaccctcct 1290 ccaggacacc actaggtggt gctggatgct tgttctttgg ccagccaagg ttcacggcga 1350 ttctccccat gggatcttga gggaccaagc tgctgggatt gggaaggagt ttcaccctga 1410 ccattgccct agccaggttc ccaggaggcc tcaccatact ccctttcagg gccagggctc 1470 cagcaagccc agggcaagga tcctgtgctg ctgtctggtt gagagcctgc caccgtgtgt 1530 cgggagtgtg ggccaggctg agtgcatagg tgacagggcc gtgagcatgg gcctgggtgt 1590 gtgtgagctc aggcctaggt gcgcagtgtg gagacgggtg ttgtcgggga agaggtgtgg 1650 cttcaaagtg tgtgtgtgca gggggtgggt gtgttagcgt gggttagggg aacgtgtgtg 1710 cgcgtgctgg tgggcatgtg agatgagtga ctgccggtga atgtgtccac agttgagagg 1770 ttggagcagg atgagggaat cctgtcacca tcaataatca cttgtggagc gccagctctg 1830 cccaaggcgc cacctgggcg gacagccagg agctctccat ggccaggctg cctgtgtgca 1890 tgttccctgt ctggtgcccc tttgcccgcc tcctgcaaac ctcacagggt ccccacacaa 1950 cagtgccctc cagaagcagc ccctcggagg cagaggaagg aaaatgggga tggctggggc 2010 tctctccatc ctccttttct ccttgccttc gcatggctgg ccttcccctc caaaacctcc 2070 attcccctgc tgccagcccc tttgccatag cctgattttg gggaggagga aggggcgatt 2130 tgagggagaa ggggagaaag cttatggctg ggtctggttt cttcccttcc cagagggtct 2190 tactgctcca gggtggcccc agggcaggca ggggccacac tatgcctgcg ccctggtaaa 2250 ggtgacccct gccacttacc agcagccctg gcatgttcct gccccacagg aatagaatgg 2310 agggagctcc agaaactttc catcccaaag gcagtctccg tggttgaagc agactggatt 2370 tttgctctgc ccctgacccc ttgtccctct ttgagggagg ggagctatgc taggactcca 2430 acctcaggga ctcgggtggc ctgcgctagc ttcttttgat actgaaaact tttaaggtgg 2490 gagggtggca agggatgtgc ttaataaatc aattccaagc ctc 2533 <210> 190 <211> 269 <212> PRT <213> Homo sapiens <400> 190 Met Ala Gly Leu Ala Ala Arg Leu Val Leu Leu Ala Gly Ala Ala Ala 1 5 10 15 Leu Ala Ser Gly Ser Gln Gly Asp Arg Glu Pro Val Tyr Arg Asp Cys 20 25 30 Val Leu Gln Cys Glu Glu Gln Asn Cys Ser Gly Gly Ala Leu Asn His 35 40 45 Phe Arg Ser Arg Gln Pro Ile Tyr Met Ser Leu Ala Gly Trp Thr Cys 50 55 60 Arg Asp Asp Cys Lys Tyr Glu Cys Met Trp Val Thr Val Gly Leu Tyr 65 70 75 80 Leu Gln Glu Gly His Lys Val Pro Gln Phe His Gly Lys Val Ser Leu 85 90 95 Asn Ala Trp Phe Trp Pro Thr Val Phe His Thr Arg Asp Thr Asp Leu 100 105 110 Thr Glu Lys Met Asp Tyr Phe Cys Ala Ser Thr Val Ile Leu His Ser 115 120 125 Ile Tyr Leu Cys Cys Val Arg Thr Val Gly Leu Gln His Pro Ala Val 130 135 140 Val Ser Ala Phe Arg Ala Leu Leu Leu Leu Met Leu Thr Val His Val 145 150 155 160 Ser Tyr Leu Ser Leu Ile Arg Phe Asp Tyr Gly Tyr Asn Leu Val Ala 165 170 175 Asn Val Ala Ile Gly Leu Val Asn Val Val Trp Trp Leu Ala Trp Cys 180 185 190 Leu Trp Asn Gln Arg Arg Leu Pro His Val Arg Lys Arg Val Val Val 195 200 205 Val Leu Leu Leu Gln Gly Leu Ser Leu Leu Glu Leu Leu Asp Phe Pro 210 215 220 Pro Leu Phe Trp Val Leu Asp Ala His Ala Ile Trp His Ile Ser Thr 225 230 235 240 Ile Pro Val His Val Leu Phe Phe Ser Phe Leu Glu Asp Asp Ser Leu 245 250 255 Tyr Leu Leu Lys Glu Ser Glu Asp Lys Phe Lys Leu Asp 260 265 <210> 191 <211> 1792 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (187)..(798) <400> 191 aaaaagcggg tccgagccgc cgccgcgcgc gcgccgcgca ctgcagcccc aggccccggc 60 cccccaccca cgtctgcgtt gctgccccgc ctgggccagg ccccaaaggc aaggacaaag 120 cagctgtcag ggaacctccg ccggagtcga atttacgtgc agctgccggc aaccacaggt 180 accaag atg gtt tgc ggg ggc ttc gcg tgt tcc aag aac tgc ctg tgc 228 Met Val Cys Gly Gly Phe Ala Cys Ser Lys Asn Cys Leu Cys 1 5 10 gcc ctc aac ctg ctt tac acc ttg gtt agt ctg ctg cta att gga att 276 Ala Leu Asn Leu Leu Tyr Thr Leu Val Ser Leu Leu Leu Ile Gly Ile 15 20 25 30 gct gcg tgg ggc att ggc ttc ggg ctg att tcc agt ctc cga gtg gtc 324 Ala Ala Trp Gly Ile Gly Phe Gly Leu Ile Ser Ser Leu Arg Val Val 35 40 45 ggc gtg gtc att gca gtg ggc atc ttc ttg ttc ctg att gct tta gtg 372 Gly Val Val Ile Ala Val Gly Ile Phe Leu Phe Leu Ile Ala Leu Val 50 55 60 ggt ctg att gga gct gta aaa cat cat cag gtg ttg cta ttt ttt tat 420 Gly Leu Ile Gly Ala Val Lys His His Gln Val Leu Leu Phe Phe Tyr 65 70 75 atg att att ctg tta ctt gta ttt att gtt cag tct tct gta tct tgc 468 Met Ile Ile Leu Leu Leu Val Phe Ile Val Gln Ser Ser Val Ser Cys 80 85 90 gct tgt tta gcc ctg aac cag gag caa cag ggt cag ctt ctg gag gtt 516 Ala Cys Leu Ala Leu Asn Gln Glu Gln Gln Gly Gln Leu Leu Glu Val 95 100 105 110 ggt tgg aac aat acg gca agt gct cga aat gac atc cag aga aat cta 564 Gly Trp Asn Asn Thr Ala Ser Ala Arg Asn Asp Ile Gln Arg Asn Leu 115 120 125 aac tgc tgt ggg ttc cga agt gtt aac cca aat gac acc tgt ctg gct 612 Asn Cys Cys Gly Phe Arg Ser Val Asn Pro Asn Asp Thr Cys Leu Ala 130 135 140 agc tgt gtt aaa agt gac cac tcg tgc tcg cca tgt gct cca atc ata 660 Ser Cys Val Lys Ser Asp His Ser Cys Ser Pro Cys Ala Pro Ile Ile 145 150 155 gga gaa tat gct gga gag gtt ttg aga ttt gtt ggt ggc att ggc ctg 708 Gly Glu Tyr Ala Gly Glu Val Leu Arg Phe Val Gly Gly Ile Gly Leu 160 165 170 ttc ttc agt ttt aca gag atc ctg ggt gtt tgg ctg acc tac aga tac 756 Phe Phe Ser Phe Thr Glu Ile Leu Gly Val Trp Leu Thr Tyr Arg Tyr 175 180 185 190 agg aac cag aaa gac ccc cgc gcg aat cct agt gca ttc ctt 798 Arg Asn Gln Lys Asp Pro Arg Ala Asn Pro Ser Ala Phe Leu 195 200 tgatgagaaa acaaggaaga tttcctttcg tattatgatc ttgttcactt tctgtaattt 858 tctgttaagc tccatttgcc agtttaagga aggaaacact atctggaaaa gtaccttatt 918 gatagtggaa ttatatattt ttactctatg tttctctaca tgtttttttc tttccgttgc 978 tgaaaaatat ttgaaacttg tggtctctga agctcggtgg cacctggaat ttactgtatt 1038 cattgtcggg cactgtccac tgtggccttt cttagcattt ttacctgcag aaaaactttg 1098 tatggtacca ctgtgttggt tatatggtga atctgaacgt acatctcact ggtataatta 1158 tatgtagcac tgtgctgtgt agatagttcc tactggaaaa agagtggaaa tttattaaaa 1218 tcagaaagta tgagatcctg ttatgttaag ggaaatccaa attcccaatt ttttttggtc 1278 tttttaggaa agatgtgttg tggtaaaaag tgttagtata aaaatgataa tttacttgta 1338 gtcttttatg attacaccaa tgtattctag aaatagttat gtcttaggaa attgtggttt 1398 aatttttgac ttttacaggt aagtgcaaag gagaagtggt ttcatgaaat gttctaatgt 1458 ataataacat ttaccttcag cctccatcag aatggaacga gttttgagta atcaggaagt 1518 atatctatat gatcttgata ttgttttata ataatttgaa gtctaaaaga ctgcattttt 1578 aaacaagtta gtattaatgc gttggcccac gtagcaaaaa gatatttgat tatcttaaaa 1638 attgttaaat accgttttca tgaaagttct cagtattgta acagcaactt gtcaaaccta 1698 agcatatttg aatatgatct cccataattt gaaattgaaa tcgtattgtg tggctctgta 1758 tattctgtta aaaaattaaa ggacagaaac cttt 1792 <210> 192 <211> 204 <212> PRT <213> Homo sapiens <400> 192 Met Val Cys Gly Gly Phe Ala Cys Ser Lys Asn Cys Leu Cys Ala Leu 1 5 10 15 Asn Leu Leu Tyr Thr Leu Val Ser Leu Leu Leu Ile Gly Ile Ala Ala 20 25 30 Trp Gly Ile Gly Phe Gly Leu Ile Ser Ser Leu Arg Val Val Gly Val 35 40 45 Val Ile Ala Val Gly Ile Phe Leu Phe Leu Ile Ala Leu Val Gly Leu 50 55 60 Ile Gly Ala Val Lys His His Gln Val Leu Leu Phe Phe Tyr Met Ile 65 70 75 80 Ile Leu Leu Leu Val Phe Ile Val Gln Ser Ser Val Ser Cys Ala Cys 85 90 95 Leu Ala Leu Asn Gln Glu Gln Gln Gly Gln Leu Leu Glu Val Gly Trp 100 105 110 Asn Asn Thr Ala Ser Ala Arg Asn Asp Ile Gln Arg Asn Leu Asn Cys 115 120 125 Cys Gly Phe Arg Ser Val Asn Pro Asn Asp Thr Cys Leu Ala Ser Cys 130 135 140 Val Lys Ser Asp His Ser Cys Ser Pro Cys Ala Pro Ile Ile Gly Glu 145 150 155 160 Tyr Ala Gly Glu Val Leu Arg Phe Val Gly Gly Ile Gly Leu Phe Phe 165 170 175 Ser Phe Thr Glu Ile Leu Gly Val Trp Leu Thr Tyr Arg Tyr Arg Asn 180 185 190 Gln Lys Asp Pro Arg Ala Asn Pro Ser Ala Phe Leu 195 200 <210> 193 <211> 2622 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (85)..(1143) <400> 193 aaaagcgctg gccggagggc ccgcggccgg gccgccgggg tgagcgtgtc gaggcggctg 60 tggcgcaggc ttccagcccc cacc atg ccg tgg ccc ctg ctg ctg ctg ctg 111 Met Pro Trp Pro Leu Leu Leu Leu Leu 1 5 gcc gtg agt ggg gcc cag aca acc cgg cca tgc ttc ccc ggg tgc caa 159 Ala Val Ser Gly Ala Gln Thr Thr Arg Pro Cys Phe Pro Gly Cys Gln 10 15 20 25 tgc gag gtg gag acc ttc ggc ctt ttc gac agc ttc agc ctg act cgg 207 Cys Glu Val Glu Thr Phe Gly Leu Phe Asp Ser Phe Ser Leu Thr Arg 30 35 40 gtg gat tgt agc ggc ctg ggc ccc cac atc atg ccg gtg ccc atc cct 255 Val Asp Cys Ser Gly Leu Gly Pro His Ile Met Pro Val Pro Ile Pro 45 50 55 ctg gac aca gcc cac ttg gac ctg tcc tcc aac cgg ctg gag atg gtg 303 Leu Asp Thr Ala His Leu Asp Leu Ser Ser Asn Arg Leu Glu Met Val 60 65 70 aat gag tcg gtg ttg gcg ggg ccg ggc tac acg acg ttg gct ggc ctg 351 Asn Glu Ser Val Leu Ala Gly Pro Gly Tyr Thr Thr Leu Ala Gly Leu 75 80 85 gat ctc agc cac aac ctg ctc acc agc atc tca ccc act gcc ttc tcc 399 Asp Leu Ser His Asn Leu Leu Thr Ser Ile Ser Pro Thr Ala Phe Ser 90 95 100 105 cgc ctt cgc tac ctg gag tcg ctt gac ctc agc cac aat ggc ctg aca 447 Arg Leu Arg Tyr Leu Glu Ser Leu Asp Leu Ser His Asn Gly Leu Thr 110 115 120 gcc ctg cca gcc gag agc ttc acc agc tca ccc ctg agc gac gtg aac 495 Ala Leu Pro Ala Glu Ser Phe Thr Ser Ser Pro Leu Ser Asp Val Asn 125 130 135 ctt agc cac aac cag ctc cgg gag gtc tca gtg tct gcc ttc acg acg 543 Leu Ser His Asn Gln Leu Arg Glu Val Ser Val Ser Ala Phe Thr Thr 140 145 150 cac agt cag ggc cgg gca cta cac gtg gac ctc tcc cac aac ctc att 591 His Ser Gln Gly Arg Ala Leu His Val Asp Leu Ser His Asn Leu Ile 155 160 165 cac cgc ctc gtg ccc cac ccc acg agg gcc ggc ctg cct gcg ccc acc 639 His Arg Leu Val Pro His Pro Thr Arg Ala Gly Leu Pro Ala Pro Thr 170 175 180 185 att cag agc ctg aac ctg gcc tgg aac cgg ctc cat gcc gtg ccc aac 687 Ile Gln Ser Leu Asn Leu Ala Trp Asn Arg Leu His Ala Val Pro Asn 190 195 200 ctc cga gac ttg ccc ctg cgc tac ctg agc ctg gat ggg aac cct cta 735 Leu Arg Asp Leu Pro Leu Arg Tyr Leu Ser Leu Asp Gly Asn Pro Leu 205 210 215 gct gtc att ggt ccg ggt gcc ttc gcg ggg ctg gga ggc ctt aca cac 783 Ala Val Ile Gly Pro Gly Ala Phe Ala Gly Leu Gly Gly Leu Thr His 220 225 230 ctg tct ctg gcc agc ctg cag agg ctc cct gag ctg gcg ccc agt ggc 831 Leu Ser Leu Ala Ser Leu Gln Arg Leu Pro Glu Leu Ala Pro Ser Gly 235 240 245 ttc cgt gag cta ccg ggc ctg cag gtc ctg gac ctg tcg ggc aac ccc 879 Phe Arg Glu Leu Pro Gly Leu Gln Val Leu Asp Leu Ser Gly Asn Pro 250 255 260 265 aag ctt aac tgg gca gga gct gag gtg ttt tca ggc ctg agc tcc ctg 927 Lys Leu Asn Trp Ala Gly Ala Glu Val Phe Ser Gly Leu Ser Ser Leu 270 275 280 cag gag ctg gac ctt tcg ggc acc aac ctg gtg ccc ctg cct gag gcg 975 Gln Glu Leu Asp Leu Ser Gly Thr Asn Leu Val Pro Leu Pro Glu Ala 285 290 295 ctg ctc ctc cac ctc ccg gca ctg cag agc gtc agc gtg ggc cag gat 1023 Leu Leu Leu His Leu Pro Ala Leu Gln Ser Val Ser Val Gly Gln Asp 300 305 310 gtg cgg tgc cgg cgc ctg gtg cgg gag ggc acc tac ccc cgg agg cct 1071 Val Arg Cys Arg Arg Leu Val Arg Glu Gly Thr Tyr Pro Arg Arg Pro 315 320 325 ggc tcc agc ccc aag gtg gcc ctg cac tgc gta gac acc cgg gaa tct 1119 Gly Ser Ser Pro Lys Val Ala Leu His Cys Val Asp Thr Arg Glu Ser 330 335 340 345 gct gcc agg ggc ccc acc atc ttg tgacaaatgg tgtggcccag ggccacataa 1173 Ala Ala Arg Gly Pro Thr Ile Leu 350 cagactgctg tcctgggctg cctcaggtcc cgagtaactt atgttcaatg tgccgacacc 1233 agtggggagc ccgcaggcct atgtggcagc gtcaccacag gagttgtggg cctaggagag 1293 gctttggacc tgggagccac acctaggagc aaagtctcac ccctttgtct acgttgcttc 1353 cccaaaccat gagcagaggg acttcgatgc caaaccagac tcgggtcccc tcctgcttcc 1413 cttccccact tatcccccaa gtgccttccc tcatgcctgg gccggcctga cccgcaatgg 1473 gcagagggtg ggtgggaccc cctgctgcag ggcagagttc aggtccactg ggctgagtgt 1533 ccccttgggc ccatggccca gtcactcagg ggcgagtttc ttttctaaca tagccctttc 1593 tttgccatga ggccatgagg cccgcttcat ccttttctat ttccctagaa ccttaatggt 1653 agaaggaatt gcaaagaatc aagtccaccc ttctcatgtg acagatgggg aaactgaggc 1713 cttgagaagg aaaaaggcta atctaagttc ctgcgggcag tggcatgact ggagcacagc 1773 ctcctgcctc ccagcccgga cccaatgcac tttcttgtct cctctaataa gccccaccct 1833 ccccgcctgg gctccccttg ctgcccttgc ctgttcccca ttagcacagg agtagcagca 1893 gcaggacagg caagagcctc acaagtggga ctctgggcct ctgaccagct gtgcggcatg 1953 ggctaagtca ctctgccctt cgggagcctc tggaagctta gggctcattg gttccagcct 2013 agccagtttc tcaccctggg ttggggtccc ccagcatcca gactggaaac ctacccattt 2073 tcccctgagc atcctctaga tgctgcccca aggagttgct gcagttctgg agcctcatct 2133 ggctgggatc tccaaggggc ctcctggatt cagtccccac tggccctgag cacgacagcc 2193 cttcttaccc tcccaggaat gccgtgaaag gagacaaggt ctgcccgacc catgtctatg 2253 ctctaccccc agggtagcat ctcagcttcc gaaccctggg ctgtttcctt agtcttcatt 2313 ttataaaagt tgttgccttt ttaacggagt gtcactttca accggcctcc cctacccctg 2373 ctggccgggg atggagacat gtcatttgta aaagcagaaa aaggttgcat ttgttcactt 2433 ttgtaatatt gtcctgggcc tgtgttgggg tgttggggga agctgggcat cagtggccac 2493 atgggcatca ggggctggcc ccacagagac cccacagggc agtgagctct gtcttccccc 2553 acctgcctag cccatcatct atctaaccgg tccttgattt aataaacact ataaaaagtt 2613 ctttgcttt 2622 <210> 194 <211> 353 <212> PRT <213> Homo sapiens <400> 194 Met Pro Trp Pro Leu Leu Leu Leu Leu Ala Val Ser Gly Ala Gln Thr 1 5 10 15 Thr Arg Pro Cys Phe Pro Gly Cys Gln Cys Glu Val Glu Thr Phe Gly 20 25 30 Leu Phe Asp Ser Phe Ser Leu Thr Arg Val Asp Cys Ser Gly Leu Gly 35 40 45 Pro His Ile Met Pro Val Pro Ile Pro Leu Asp Thr Ala His Leu Asp 50 55 60 Leu Ser Ser Asn Arg Leu Glu Met Val Asn Glu Ser Val Leu Ala Gly 65 70 75 80 Pro Gly Tyr Thr Thr Leu Ala Gly Leu Asp Leu Ser His Asn Leu Leu 85 90 95 Thr Ser Ile Ser Pro Thr Ala Phe Ser Arg Leu Arg Tyr Leu Glu Ser 100 105 110 Leu Asp Leu Ser His Asn Gly Leu Thr Ala Leu Pro Ala Glu Ser Phe 115 120 125 Thr Ser Ser Pro Leu Ser Asp Val Asn Leu Ser His Asn Gln Leu Arg 130 135 140 Glu Val Ser Val Ser Ala Phe Thr Thr His Ser Gln Gly Arg Ala Leu 145 150 155 160 His Val Asp Leu Ser His Asn Leu Ile His Arg Leu Val Pro His Pro 165 170 175 Thr Arg Ala Gly Leu Pro Ala Pro Thr Ile Gln Ser Leu Asn Leu Ala 180 185 190 Trp Asn Arg Leu His Ala Val Pro Asn Leu Arg Asp Leu Pro Leu Arg 195 200 205 Tyr Leu Ser Leu Asp Gly Asn Pro Leu Ala Val Ile Gly Pro Gly Ala 210 215 220 Phe Ala Gly Leu Gly Gly Leu Thr His Leu Ser Leu Ala Ser Leu Gln 225 230 235 240 Arg Leu Pro Glu Leu Ala Pro Ser Gly Phe Arg Glu Leu Pro Gly Leu 245 250 255 Gln Val Leu Asp Leu Ser Gly Asn Pro Lys Leu Asn Trp Ala Gly Ala 260 265 270 Glu Val Phe Ser Gly Leu Ser Ser Leu Gln Glu Leu Asp Leu Ser Gly 275 280 285 Thr Asn Leu Val Pro Leu Pro Glu Ala Leu Leu Leu His Leu Pro Ala 290 295 300 Leu Gln Ser Val Ser Val Gly Gln Asp Val Arg Cys Arg Arg Leu Val 305 310 315 320 Arg Glu Gly Thr Tyr Pro Arg Arg Pro Gly Ser Ser Pro Lys Val Ala 325 330 335 Leu His Cys Val Asp Thr Arg Glu Ser Ala Ala Arg Gly Pro Thr Ile 340 345 350 Leu <210> 195 <211> 2005 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (48)..(950) <400> 195 atgcgcagcg gggccgtggg tgtacgcggc gcagcgcggc agtcctg atg gcc cgg 56 Met Ala Arg 1 cat ggg tta ccg ctg ctg ccc ctg ctg tcg ctc ctg gtc ggc gcg tgg 104 His Gly Leu Pro Leu Leu Pro Leu Leu Ser Leu Leu Val Gly Ala Trp 5 10 15 ctc aag cta gga aat gga cag gct act agc atg gtc caa ctg cag ggt 152 Leu Lys Leu Gly Asn Gly Gln Ala Thr Ser Met Val Gln Leu Gln Gly 20 25 30 35 ggg aga ttc ctg atg gga aca aat tct cca gac agc aga gat ggt gaa 200 Gly Arg Phe Leu Met Gly Thr Asn Ser Pro Asp Ser Arg Asp Gly Glu 40 45 50 ggg cct gtg cgg gag gcg aca gtg aaa ccc ttt gcc atc gac ata ttt 248 Gly Pro Val Arg Glu Ala Thr Val Lys Pro Phe Ala Ile Asp Ile Phe 55 60 65 cct gtc acc aac aaa gat ttc agg gat ttt gtc agg gag aaa aag tat 296 Pro Val Thr Asn Lys Asp Phe Arg Asp Phe Val Arg Glu Lys Lys Tyr 70 75 80 cgg aca gaa gct gag atg ttt gga tgg agc ttt gtc ttt gag gac ttt 344 Arg Thr Glu Ala Glu Met Phe Gly Trp Ser Phe Val Phe Glu Asp Phe 85 90 95 gtc tct gat gag ctg aga aac aaa gcc acc cag cca atg aag tct gta 392 Val Ser Asp Glu Leu Arg Asn Lys Ala Thr Gln Pro Met Lys Ser Val 100 105 110 115 ctc tgg tgg ctt cca gtg gaa aag gca ttt tgg agg cag cct gca ggt 440 Leu Trp Trp Leu Pro Val Glu Lys Ala Phe Trp Arg Gln Pro Ala Gly 120 125 130 cct ggc tct ggc atc cga gag aga ctg gag cac cca gtg tta cac gtg 488 Pro Gly Ser Gly Ile Arg Glu Arg Leu Glu His Pro Val Leu His Val 135 140 145 agc tgg aat gac gcc cgt gcc tac tgt gct tgg cgg gga aaa cga ctg 536 Ser Trp Asn Asp Ala Arg Ala Tyr Cys Ala Trp Arg Gly Lys Arg Leu 150 155 160 ccc acg gag gaa gag tgg gag ttt gcc gcc cga ggg ggc ttg aag ggt 584 Pro Thr Glu Glu Glu Trp Glu Phe Ala Ala Arg Gly Gly Leu Lys Gly 165 170 175 caa gtt tac cca tgg ggg aac tgg ttc cag cca aac cgc acc aac ctg 632 Gln Val Tyr Pro Trp Gly Asn Trp Phe Gln Pro Asn Arg Thr Asn Leu 180 185 190 195 tgg cag gga aag ttc ccc aag gga gac aaa gct gag gat ggc ttc cat 680 Trp Gln Gly Lys Phe Pro Lys Gly Asp Lys Ala Glu Asp Gly Phe His 200 205 210 gga gtc tcc cca gtg aat gct ttc ccc gcc cag aac aac tac ggg ctc 728 Gly Val Ser Pro Val Asn Ala Phe Pro Ala Gln Asn Asn Tyr Gly Leu 215 220 225 tat gac ctc ctg ggg aac gtg tgg gag tgg aca gca tca ccg tac cag 776 Tyr Asp Leu Leu Gly Asn Val Trp Glu Trp Thr Ala Ser Pro Tyr Gln 230 235 240 gct gct gag cag gac atg cgc gtc ctc cgg ggg gca tcc tgg atc gac 824 Ala Ala Glu Gln Asp Met Arg Val Leu Arg Gly Ala Ser Trp Ile Asp 245 250 255 aca gct gat ggc tct gcc aat cac cgg gcc cgg gtc acc acc agg atg 872 Thr Ala Asp Gly Ser Ala Asn His Arg Ala Arg Val Thr Thr Arg Met 260 265 270 275 ggc aac act cca gat tca gcc tca gac aac ctc ggt ttc cgc tgt gct 920 Gly Asn Thr Pro Asp Ser Ala Ser Asp Asn Leu Gly Phe Arg Cys Ala 280 285 290 gca gac gca ggc cgg ccg cca ggg gag ctg taagcagccg ggtggtgaca 970 Ala Asp Ala Gly Arg Pro Pro Gly Glu Leu 295 300 aggagaaaag ccttctaggg tcactgtcat tccctggcca tgttgcaaac agcgcaattc 1030 caagctcgag agcttcagcc tcaggaaaga acttcccctt ccctgtctcc catccctctg 1090 tggcaggcgc ctctcaccag ggcaggagag gactcagcct cctgtgtttt ggagaagggg 1150 cccaatgtgt gttgacgatg gctgggggcc aggtgtttct gttagaggcc aagtattatt 1210 gacacaggat tgcaaacaca caaacagttg gaacagagca ctctgaaagg ccatttttta 1270 agcattttaa aatctattct ctcccccttt ctccctggat gattcaggaa gctgacattg 1330 tttcctcaag gcagaatttt cctggttctg ttttctcagc cagttgctgt ggaaggagaa 1390 tgctttcttt gtggcctcat ctgtggtttc gtgtccctct gaaggaaact agtttccact 1450 gtgtaacagg cagacatgta actatttaaa gcacagttca gtcctaaaag ggtctgggag 1510 aaccagatga tgtactaggt gaagcattgc attgtgggaa tcacaaagca aatagtactc 1570 cagaaagaca aatatcagaa gcttcctatt cttttttttt tttttttttt ttttgagaca 1630 gggtctttct ctgttgccca ggctagagtg cactggtggt cacggctcac tctagccttg 1690 aattcctggg cccaagcaat tctcccacct cagcctcctg agtagctggg actacaagtg 1750 tgcaccacca tgcctggcta attttttgaa tttttgtagt gatgggatct cgctctgttg 1810 cccagggtgg tctcgaactc ctggcctcaa gcgatcctcc cacctcgacc tcccaaagtg 1870 ctgggattac aggtgtgagc cacctcgcct gggccccctt ctccatatgc ctccaaaaac 1930 atgtccctgg agagtagcct gctcccacac tgtcactgga tgtcatgggg ccaataaaat 1990 ctcctgcaat tgtgt 2005 <210> 196 <211> 301 <212> PRT <213> Homo sapiens <400> 196 Met Ala Arg His Gly Leu Pro Leu Leu Pro Leu Leu Ser Leu Leu Val 1 5 10 15 Gly Ala Trp Leu Lys Leu Gly Asn Gly Gln Ala Thr Ser Met Val Gln 20 25 30 Leu Gln Gly Gly Arg Phe Leu Met Gly Thr Asn Ser Pro Asp Ser Arg 35 40 45 Asp Gly Glu Gly Pro Val Arg Glu Ala Thr Val Lys Pro Phe Ala Ile 50 55 60 Asp Ile Phe Pro Val Thr Asn Lys Asp Phe Arg Asp Phe Val Arg Glu 65 70 75 80 Lys Lys Tyr Arg Thr Glu Ala Glu Met Phe Gly Trp Ser Phe Val Phe 85 90 95 Glu Asp Phe Val Ser Asp Glu Leu Arg Asn Lys Ala Thr Gln Pro Met 100 105 110 Lys Ser Val Leu Trp Trp Leu Pro Val Glu Lys Ala Phe Trp Arg Gln 115 120 125 Pro Ala Gly Pro Gly Ser Gly Ile Arg Glu Arg Leu Glu His Pro Val 130 135 140 Leu His Val Ser Trp Asn Asp Ala Arg Ala Tyr Cys Ala Trp Arg Gly 145 150 155 160 Lys Arg Leu Pro Thr Glu Glu Glu Trp Glu Phe Ala Ala Arg Gly Gly 165 170 175 Leu Lys Gly Gln Val Tyr Pro Trp Gly Asn Trp Phe Gln Pro Asn Arg 180 185 190 Thr Asn Leu Trp Gln Gly Lys Phe Pro Lys Gly Asp Lys Ala Glu Asp 195 200 205 Gly Phe His Gly Val Ser Pro Val Asn Ala Phe Pro Ala Gln Asn Asn 210 215 220 Tyr Gly Leu Tyr Asp Leu Leu Gly Asn Val Trp Glu Trp Thr Ala Ser 225 230 235 240 Pro Tyr Gln Ala Ala Glu Gln Asp Met Arg Val Leu Arg Gly Ala Ser 245 250 255 Trp Ile Asp Thr Ala Asp Gly Ser Ala Asn His Arg Ala Arg Val Thr 260 265 270 Thr Arg Met Gly Asn Thr Pro Asp Ser Ala Ser Asp Asn Leu Gly Phe 275 280 285 Arg Cys Ala Ala Asp Ala Gly Arg Pro Pro Gly Glu Leu 290 295 300 <210> 197 <211> 2012 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (305)..(1549) <400> 197 aaaacgggat attcagcagt ggcctgtggc tgccagagca gctcctcagg ggaaactaag 60 cgtcgagtca gacggcacca taatcgcctt taaaagtgcc tccgccctgc cggccgcgta 120 tcccccggct acctgggccg ccccgcggcg gtgcgcgcgt gagagggagc gcgcgggcag 180 ccgagcgccg gtgtgagcca gcgctgctgc cagtgtgagc ggcggtgtga gcgcggtggg 240 tgcggagggg cgtgtgtgcc ggcgcgcgcg ccgtggggtg caaaccccga gcgtctacgc 300 tgcc atg agg ggc gcg aac gcc tgg gcg cca ctc tgc ctg ctg ctg gct 349 Met Arg Gly Ala Asn Ala Trp Ala Pro Leu Cys Leu Leu Leu Ala 1 5 10 15 gcc gcc acc cag ctc tcg cgg cag cag tcc cca gag aga cct gtt ttc 397 Ala Ala Thr Gln Leu Ser Arg Gln Gln Ser Pro Glu Arg Pro Val Phe 20 25 30 aca tgt ggt ggc att ctt act gga gag tct gga ttt att ggc agt gaa 445 Thr Cys Gly Gly Ile Leu Thr Gly Glu Ser Gly Phe Ile Gly Ser Glu 35 40 45 ggt ttt cct gga gtg tac cct cca aat agc aaa tgt act tgg aaa atc 493 Gly Phe Pro Gly Val Tyr Pro Pro Asn Ser Lys Cys Thr Trp Lys Ile 50 55 60 aca gtt ccc gaa gga aaa gta gtc gtt ctc aat ttc cga ttc ata gac 541 Thr Val Pro Glu Gly Lys Val Val Val Leu Asn Phe Arg Phe Ile Asp 65 70 75 ctc gag agt gac aac ctg tgc cgc tat gac ttt gtg gat gtg tac aat 589 Leu Glu Ser Asp Asn Leu Cys Arg Tyr Asp Phe Val Asp Val Tyr Asn 80 85 90 95 ggc cat gcc aat ggc cag cgc att ggc cgc ttc tgt ggc act ttc cgg 637 Gly His Ala Asn Gly Gln Arg Ile Gly Arg Phe Cys Gly Thr Phe Arg 100 105 110 cct gga gcc ctt gtg tcc agt ggc aac aag atg atg gtg cag atg att 685 Pro Gly Ala Leu Val Ser Ser Gly Asn Lys Met Met Val Gln Met Ile 115 120 125 tct gat gcc aac aca gct ggc aat ggc ttc atg gcc atg ttc tcc gct 733 Ser Asp Ala Asn Thr Ala Gly Asn Gly Phe Met Ala Met Phe Ser Ala 130 135 140 gct gaa cca aac gaa aga ggg gat cag tat tgt gga gga ctc ctt gac 781 Ala Glu Pro Asn Glu Arg Gly Asp Gln Tyr Cys Gly Gly Leu Leu Asp 145 150 155 aga cct tcc ggc tct ttt aaa acc ccc aac tgg cca gac cgg gat tac 829 Arg Pro Ser Gly Ser Phe Lys Thr Pro Asn Trp Pro Asp Arg Asp Tyr 160 165 170 175 cct gca gga gtc act tgt gtg tgg cac att gta gcc cca aag aat cag 877 Pro Ala Gly Val Thr Cys Val Trp His Ile Val Ala Pro Lys Asn Gln 180 185 190 ctt ata gaa tta aag ttt gag aag ttt gat gtg gag cga gat aac tac 925 Leu Ile Glu Leu Lys Phe Glu Lys Phe Asp Val Glu Arg Asp Asn Tyr 195 200 205 tgc cga tat gat tat gtg gct gtg ttt aat ggc ggg gaa gtc aac gat 973 Cys Arg Tyr Asp Tyr Val Ala Val Phe Asn Gly Gly Glu Val Asn Asp 210 215 220 gct aga aga att gga aag tat tgt ggt gat agt cca cct gcg cca att 1021 Ala Arg Arg Ile Gly Lys Tyr Cys Gly Asp Ser Pro Pro Ala Pro Ile 225 230 235 gtg tct gag aga aat gaa ctt ctt att cag ttt tta tca gac tta agt 1069 Val Ser Glu Arg Asn Glu Leu Leu Ile Gln Phe Leu Ser Asp Leu Ser 240 245 250 255 tta act gca gat ggg ttt att ggt cac tac ata ttc agg cca aaa aaa 1117 Leu Thr Ala Asp Gly Phe Ile Gly His Tyr Ile Phe Arg Pro Lys Lys 260 265 270 ctg cct aca act aca gaa cag cct gtc acc acc aca ttc cct gta acc 1165 Leu Pro Thr Thr Thr Glu Gln Pro Val Thr Thr Thr Phe Pro Val Thr 275 280 285 acg ggt tta aaa ccc acc gtg gcc ttg tgt caa caa aag tgt aga cgg 1213 Thr Gly Leu Lys Pro Thr Val Ala Leu Cys Gln Gln Lys Cys Arg Arg 290 295 300 acg ggg act ctg gag ggc aat tat tgt tca agt gac ttt gta tta gcc 1261 Thr Gly Thr Leu Glu Gly Asn Tyr Cys Ser Ser Asp Phe Val Leu Ala 305 310 315 ggc act gtt atc aca acc atc act cgc gat ggg agt ttg cac gcc aca 1309 Gly Thr Val Ile Thr Thr Ile Thr Arg Asp Gly Ser Leu His Ala Thr 320 325 330 335 gtc tcg atc atc aac atc tac aaa gag gga aat ttg gcg att cag cag 1357 Val Ser Ile Ile Asn Ile Tyr Lys Glu Gly Asn Leu Ala Ile Gln Gln 340 345 350 gcg ggc aag aac atg agt gcc agg ctg act gtc gtc tgc aag cag tgc 1405 Ala Gly Lys Asn Met Ser Ala Arg Leu Thr Val Val Cys Lys Gln Cys 355 360 365 cct ccc ctc aga aga ggt cta aat tac att att atg ggc caa gta ggt 1453 Pro Pro Leu Arg Arg Gly Leu Asn Tyr Ile Ile Met Gly Gln Val Gly 370 375 380 gaa gat ggg cga ggc aaa atc atg cca aac agc ttt atc atg atg ttc 1501 Glu Asp Gly Arg Gly Lys Ile Met Pro Asn Ser Phe Ile Met Met Phe 385 390 395 aag acc aag aat cag aag ctc ctg gat gcc tta aaa aat aag caa tgt 1549 Lys Thr Lys Asn Gln Lys Leu Leu Asp Ala Leu Lys Asn Lys Gln Cys 400 405 410 415 taacagtgaa ctgtgtccat ttaagctgta ttctgccatt gcctttgaaa gatctatgtt 1609 ctctcagtag aaaaaaaaat acttataaaa ttacatattc tgaaagagga ttccgaaaga 1669 tgggactggt tgactcttca catgatggag gtatgaggcc tccgagatag ctgagggaag 1729 ttctttgcct gctgtcagag gagcagctat ctgattggaa acctgccgac ttagtgcggt 1789 gataggaagc taaaagtgtc aagcgttgac agcttggaag cgtttattta tacatctctg 1849 taaaaggata ttttagaatt gagttgtgtg aagatgtcaa aaaaagattt tagaagtgca 1909 atatttatag tgttatttgt ttcaccttca agcctttgcc ctgaggtgtt acaaccttgt 1969 cttgcgtttt ctaaatcaat gcttaataaa atatttttaa agg 2012 <210> 198 <211> 415 <212> PRT <213> Homo sapiens <400> 198 Met Arg Gly Ala Asn Ala Trp Ala Pro Leu Cys Leu Leu Leu Ala Ala 1 5 10 15 Ala Thr Gln Leu Ser Arg Gln Gln Ser Pro Glu Arg Pro Val Phe Thr 20 25 30 Cys Gly Gly Ile Leu Thr Gly Glu Ser Gly Phe Ile Gly Ser Glu Gly 35 40 45 Phe Pro Gly Val Tyr Pro Pro Asn Ser Lys Cys Thr Trp Lys Ile Thr 50 55 60 Val Pro Glu Gly Lys Val Val Val Leu Asn Phe Arg Phe Ile Asp Leu 65 70 75 80 Glu Ser Asp Asn Leu Cys Arg Tyr Asp Phe Val Asp Val Tyr Asn Gly 85 90 95 His Ala Asn Gly Gln Arg Ile Gly Arg Phe Cys Gly Thr Phe Arg Pro 100 105 110 Gly Ala Leu Val Ser Ser Gly Asn Lys Met Met Val Gln Met Ile Ser 115 120 125 Asp Ala Asn Thr Ala Gly Asn Gly Phe Met Ala Met Phe Ser Ala Ala 130 135 140 Glu Pro Asn Glu Arg Gly Asp Gln Tyr Cys Gly Gly Leu Leu Asp Arg 145 150 155 160 Pro Ser Gly Ser Phe Lys Thr Pro Asn Trp Pro Asp Arg Asp Tyr Pro 165 170 175 Ala Gly Val Thr Cys Val Trp His Ile Val Ala Pro Lys Asn Gln Leu 180 185 190 Ile Glu Leu Lys Phe Glu Lys Phe Asp Val Glu Arg Asp Asn Tyr Cys 195 200 205 Arg Tyr Asp Tyr Val Ala Val Phe Asn Gly Gly Glu Val Asn Asp Ala 210 215 220 Arg Arg Ile Gly Lys Tyr Cys Gly Asp Ser Pro Pro Ala Pro Ile Val 225 230 235 240 Ser Glu Arg Asn Glu Leu Leu Ile Gln Phe Leu Ser Asp Leu Ser Leu 245 250 255 Thr Ala Asp Gly Phe Ile Gly His Tyr Ile Phe Arg Pro Lys Lys Leu 260 265 270 Pro Thr Thr Thr Glu Gln Pro Val Thr Thr Thr Phe Pro Val Thr Thr 275 280 285 Gly Leu Lys Pro Thr Val Ala Leu Cys Gln Gln Lys Cys Arg Arg Thr 290 295 300 Gly Thr Leu Glu Gly Asn Tyr Cys Ser Ser Asp Phe Val Leu Ala Gly 305 310 315 320 Thr Val Ile Thr Thr Ile Thr Arg Asp Gly Ser Leu His Ala Thr Val 325 330 335 Ser Ile Ile Asn Ile Tyr Lys Glu Gly Asn Leu Ala Ile Gln Gln Ala 340 345 350 Gly Lys Asn Met Ser Ala Arg Leu Thr Val Val Cys Lys Gln Cys Pro 355 360 365 Pro Leu Arg Arg Gly Leu Asn Tyr Ile Ile Met Gly Gln Val Gly Glu 370 375 380 Asp Gly Arg Gly Lys Ile Met Pro Asn Ser Phe Ile Met Met Phe Lys 385 390 395 400 Thr Lys Asn Gln Lys Leu Leu Asp Ala Leu Lys Asn Lys Gln Cys 405 410 415 <210> 199 <211> 1740 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (40)..(1257) <400> 199 gcacgttcct tctactctgg caccactctc caggctgcc atg ggg ccc agc acc 54 Met Gly Pro Ser Thr 1 5 cct ctc ctc atc ttg ttc ctt ttg tca tgg tcg gga ccc ctc caa gga 102 Pro Leu Leu Ile Leu Phe Leu Leu Ser Trp Ser Gly Pro Leu Gln Gly 10 15 20 cag cag cac cac ctt gtg gag tac atg gaa cgc cga cta gct gct tta 150 Gln Gln His His Leu Val Glu Tyr Met Glu Arg Arg Leu Ala Ala Leu 25 30 35 gag gaa cgg ctg gcc cag tgc cag gac cag agt agt cgg cat gct gct 198 Glu Glu Arg Leu Ala Gln Cys Gln Asp Gln Ser Ser Arg His Ala Ala 40 45 50 gag ctg cgg gac ttc aag aac aag atg ctg cca ctg ctg gag gtg gca 246 Glu Leu Arg Asp Phe Lys Asn Lys Met Leu Pro Leu Leu Glu Val Ala 55 60 65 gag aag gag cgg gag gca ctc aga act gag gcc gac acc atc tcc ggg 294 Glu Lys Glu Arg Glu Ala Leu Arg Thr Glu Ala Asp Thr Ile Ser Gly 70 75 80 85 aga gtg gat cgt ctg gag cgg gag gta gac tat ctg gag acc cag aac 342 Arg Val Asp Arg Leu Glu Arg Glu Val Asp Tyr Leu Glu Thr Gln Asn 90 95 100 cca gct ctg ccc tgt gta gag ttt gat gag aag gtg act gga ggc cct 390 Pro Ala Leu Pro Cys Val Glu Phe Asp Glu Lys Val Thr Gly Gly Pro 105 110 115 ggg acc aaa ggc aag gga aga agg aat gag aag tac gat atg gtg aca 438 Gly Thr Lys Gly Lys Gly Arg Arg Asn Glu Lys Tyr Asp Met Val Thr 120 125 130 gac tgt ggc tac aca atc tct caa gtg aga tca atg aag att ctg aag 486 Asp Cys Gly Tyr Thr Ile Ser Gln Val Arg Ser Met Lys Ile Leu Lys 135 140 145 cga ttt ggt ggc cca gct ggt cta tgg acc aag gat cca ctg ggg caa 534 Arg Phe Gly Gly Pro Ala Gly Leu Trp Thr Lys Asp Pro Leu Gly Gln 150 155 160 165 aca gag aag atc tac gtg tta gat ggg aca cag aat gac aca gcc ttt 582 Thr Glu Lys Ile Tyr Val Leu Asp Gly Thr Gln Asn Asp Thr Ala Phe 170 175 180 gtc ttc cca agg ctg cgt gac ttc acc ctt gcc atg gct gcc cgg aaa 630 Val Phe Pro Arg Leu Arg Asp Phe Thr Leu Ala Met Ala Ala Arg Lys 185 190 195 gct tcc cga gtc cgg gtg ccc ttc ccc tgg gta ggc aca ggg cag ctg 678 Ala Ser Arg Val Arg Val Pro Phe Pro Trp Val Gly Thr Gly Gln Leu 200 205 210 gta tat ggt ggc ttt ctt tat ttt gct cgg agg cct cct gga aga cct 726 Val Tyr Gly Gly Phe Leu Tyr Phe Ala Arg Arg Pro Pro Gly Arg Pro 215 220 225 ggt gga ggt ggt gag atg gag aac act ttg cag cta atc aaa ttc cac 774 Gly Gly Gly Gly Glu Met Glu Asn Thr Leu Gln Leu Ile Lys Phe His 230 235 240 245 ctg gca aac cga aca gtg gtg gac agc tca gta ttc cca gca gag ggg 822 Leu Ala Asn Arg Thr Val Val Asp Ser Ser Val Phe Pro Ala Glu Gly 250 255 260 ctg atc ccc ccc tac ggc ttg aca gca gac acc tac atc gac ctg gca 870 Leu Ile Pro Pro Tyr Gly Leu Thr Ala Asp Thr Tyr Ile Asp Leu Ala 265 270 275 gct gat gag gaa ggt ctt tgg gct gtc tat gcc acc cgg gag gat gac 918 Ala Asp Glu Glu Gly Leu Trp Ala Val Tyr Ala Thr Arg Glu Asp Asp 280 285 290 agg cac ttg tgt ctg gcc aaa tta gat cca cag aca ctg gac aca gag 966 Arg His Leu Cys Leu Ala Lys Leu Asp Pro Gln Thr Leu Asp Thr Glu 295 300 305 cag cag tgg gac aca cca tgt ccc aga gag aat gct gag gct gcc ttt 1014 Gln Gln Trp Asp Thr Pro Cys Pro Arg Glu Asn Ala Glu Ala Ala Phe 310 315 320 325 gtc atc tgt ggg acc ctc tat gtc gtc tat aac acc cgt cct gcc agt 1062 Val Ile Cys Gly Thr Leu Tyr Val Val Tyr Asn Thr Arg Pro Ala Ser 330 335 340 cgg gcc cgc atc cag tgc tcc ttt gat gcc agc ggc acc ctg acc cct 1110 Arg Ala Arg Ile Gln Cys Ser Phe Asp Ala Ser Gly Thr Leu Thr Pro 345 350 355 gaa cgg gca gca ctc cct tat ttt ccc cgc aga tat ggt gcc cat gcc 1158 Glu Arg Ala Ala Leu Pro Tyr Phe Pro Arg Arg Tyr Gly Ala His Ala 360 365 370 agc ctc cgc tat aac ccc cga gaa cgc cag ctc tat gcc tgg gat gat 1206 Ser Leu Arg Tyr Asn Pro Arg Glu Arg Gln Leu Tyr Ala Trp Asp Asp 375 380 385 ggc tac cag att gtc tat aag ctg gag atg agg aag aaa gag gag gag 1254 Gly Tyr Gln Ile Val Tyr Lys Leu Glu Met Arg Lys Lys Glu Glu Glu 390 395 400 405 gtt tgaggagcta gccttgtttt ttgcatcttt ctcactccca tacatttata 1307 Val ttatatcccc actaaatttc ttgttcctca ttcttcaaat gtgggccagt tgtggctcaa 1367 atcctctata tttttagcca atggcaatca aattctttca gctcctttgt ttcatacgga 1427 actccagatc ctgagtaatc cttttagagc ccgaagagtc aaaaccctca atgttccctc 1487 ctgctctcct gccccatgtc aacaaatttc aggctaagga tgccccagac ccagggctct 1547 aaccttgtat gcgggcaggc ccagggagca ggcagcagtg ttcttcccct cagagtgact 1607 tggggaggga gaaataggag gagacgtcca gctctgtcct ctcttcctca ctcctccctt 1667 cagtgtcctg aggaacagga ctttctccac attgttttgt attgcaacat tttgcattaa 1727 aaggaaaatc cac 1740 <210> 200 <211> 406 <212> PRT <213> Homo sapiens <400> 200 Met Gly Pro Ser Thr Pro Leu Leu Ile Leu Phe Leu Leu Ser Trp Ser 1 5 10 15 Gly Pro Leu Gln Gly Gln Gln His His Leu Val Glu Tyr Met Glu Arg 20 25 30 Arg Leu Ala Ala Leu Glu Glu Arg Leu Ala Gln Cys Gln Asp Gln Ser 35 40 45 Ser Arg His Ala Ala Glu Leu Arg Asp Phe Lys Asn Lys Met Leu Pro 50 55 60 Leu Leu Glu Val Ala Glu Lys Glu Arg Glu Ala Leu Arg Thr Glu Ala 65 70 75 80 Asp Thr Ile Ser Gly Arg Val Asp Arg Leu Glu Arg Glu Val Asp Tyr 85 90 95 Leu Glu Thr Gln Asn Pro Ala Leu Pro Cys Val Glu Phe Asp Glu Lys 100 105 110 Val Thr Gly Gly Pro Gly Thr Lys Gly Lys Gly Arg Arg Asn Glu Lys 115 120 125 Tyr Asp Met Val Thr Asp Cys Gly Tyr Thr Ile Ser Gln Val Arg Ser 130 135 140 Met Lys Ile Leu Lys Arg Phe Gly Gly Pro Ala Gly Leu Trp Thr Lys 145 150 155 160 Asp Pro Leu Gly Gln Thr Glu Lys Ile Tyr Val Leu Asp Gly Thr Gln 165 170 175 Asn Asp Thr Ala Phe Val Phe Pro Arg Leu Arg Asp Phe Thr Leu Ala 180 185 190 Met Ala Ala Arg Lys Ala Ser Arg Val Arg Val Pro Phe Pro Trp Val 195 200 205 Gly Thr Gly Gln Leu Val Tyr Gly Gly Phe Leu Tyr Phe Ala Arg Arg 210 215 220 Pro Pro Gly Arg Pro Gly Gly Gly Gly Glu Met Glu Asn Thr Leu Gln 225 230 235 240 Leu Ile Lys Phe His Leu Ala Asn Arg Thr Val Val Asp Ser Ser Val 245 250 255 Phe Pro Ala Glu Gly Leu Ile Pro Pro Tyr Gly Leu Thr Ala Asp Thr 260 265 270 Tyr Ile Asp Leu Ala Ala Asp Glu Glu Gly Leu Trp Ala Val Tyr Ala 275 280 285 Thr Arg Glu Asp Asp Arg His Leu Cys Leu Ala Lys Leu Asp Pro Gln 290 295 300 Thr Leu Asp Thr Glu Gln Gln Trp Asp Thr Pro Cys Pro Arg Glu Asn 305 310 315 320 Ala Glu Ala Ala Phe Val Ile Cys Gly Thr Leu Tyr Val Val Tyr Asn 325 330 335 Thr Arg Pro Ala Ser Arg Ala Arg Ile Gln Cys Ser Phe Asp Ala Ser 340 345 350 Gly Thr Leu Thr Pro Glu Arg Ala Ala Leu Pro Tyr Phe Pro Arg Arg 355 360 365 Tyr Gly Ala His Ala Ser Leu Arg Tyr Asn Pro Arg Glu Arg Gln Leu 370 375 380 Tyr Ala Trp Asp Asp Gly Tyr Gln Ile Val Tyr Lys Leu Glu Met Arg 385 390 395 400 Lys Lys Glu Glu Glu Val 405 <210> 201 <211> 2308 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (269)..(934) <400> 201 aggattcttc tcatcgcagt gctccaggca gccactacca atcgattgga gttagcctgt 60 gaggaaactg gagaggcgtg gctggaccaa gacctccccc catgtgagca ggcttcctcc 120 tcccccaaca accgttgcca ccacgcccag aaacgtcctt aagccctggc cctcagggga 180 aaggtagcag gaggccagag ccgggaccat gtgacggcgc tggccctcgc caccgccgtc 240 ccccgaccct ggccccaggc ccggcacc atg atg ttc cga gac cag gtg ggc 292 Met Met Phe Arg Asp Gln Val Gly 1 5 atc ctc gct ggc tgg ttc aaa ggc tgg aat gag tgt gag cag aca gtg 340 Ile Leu Ala Gly Trp Phe Lys Gly Trp Asn Glu Cys Glu Gln Thr Val 10 15 20 gcc ctc ctg tca ctt ctg aaa cgg gtc acc cgt acc cag gcc cgc ttc 388 Ala Leu Leu Ser Leu Leu Lys Arg Val Thr Arg Thr Gln Ala Arg Phe 25 30 35 40 ctg cag ctc tgc ctg gag cac tca ctg gcg gac tgc aat gac atc cac 436 Leu Gln Leu Cys Leu Glu His Ser Leu Ala Asp Cys Asn Asp Ile His 45 50 55 ctg ctg gag tcg gag gcc aac agt gct gcc atc gtc agc cag tgg cag 484 Leu Leu Glu Ser Glu Ala Asn Ser Ala Ala Ile Val Ser Gln Trp Gln 60 65 70 cag gag tcc aaa gag aag gtg gtg tcc ctc ctg ctg tcc cac ctt ccc 532 Gln Glu Ser Lys Glu Lys Val Val Ser Leu Leu Leu Ser His Leu Pro 75 80 85 ctg ctt cag cca ggc aac aca gag gcc aag tcg gag tac atg agg cta 580 Leu Leu Gln Pro Gly Asn Thr Glu Ala Lys Ser Glu Tyr Met Arg Leu 90 95 100 ctg cag aaa gtg ctg gcc tac tca atc gag agc aat gct ttc atc gag 628 Leu Gln Lys Val Leu Ala Tyr Ser Ile Glu Ser Asn Ala Phe Ile Glu 105 110 115 120 gag agt cgc cag ctg ctt tcc tat gcc ctc atc cac cca gcc acc aca 676 Glu Ser Arg Gln Leu Leu Ser Tyr Ala Leu Ile His Pro Ala Thr Thr 125 130 135 ctg gag gac cgc aac gca ctg gcc ctc tgg ctg agc cac ctg gaa gag 724 Leu Glu Asp Arg Asn Ala Leu Ala Leu Trp Leu Ser His Leu Glu Glu 140 145 150 cgg ttg gct agt ggc ttc cgc tcc cgg cca gag ccc tcc tac cat tca 772 Arg Leu Ala Ser Gly Phe Arg Ser Arg Pro Glu Pro Ser Tyr His Ser 155 160 165 cgt caa ggc tca gat gag tgg ggg ggc cct gca gag cta ggc cct ggg 820 Arg Gln Gly Ser Asp Glu Trp Gly Gly Pro Ala Glu Leu Gly Pro Gly 170 175 180 gag gca ggg cca ggc tgg cag gac aag cca ccc cgg gaa aat gga cac 868 Glu Ala Gly Pro Gly Trp Gln Asp Lys Pro Pro Arg Glu Asn Gly His 185 190 195 200 gtg ccc ttc cac cca tcc agc tca gtg ccg cca gcc atc aac agt att 916 Val Pro Phe His Pro Ser Ser Ser Val Pro Pro Ala Ile Asn Ser Ile 205 210 215 ggg agc aat ttc agc tta tgaacccctg taaagcaatt tcagctttgc 964 Gly Ser Asn Phe Ser Leu 220 ttcatggtat atttgctttc tatccagagg ttaattcgtt agttttctta aaacaatgtt 1024 tttcttaatg gtcttattgt ttagaagtaa caagtggact ggaaaagtat atggggccta 1084 agtttataac attgtcttct cattatcagg gaaaaaggag aagccaaaga agttcactag 1144 acaaccaaaa aagcaggtat cttcaccctg tgcccagagg aaagaaaagg cattggagaa 1204 gtcagcttct agagatgtgt ctcctttcgt tatgagtatg cagaagaata agtgggatgc 1264 cacaagatcc ttgagattca accaggatgc acaaagagaa gacgatcaac ggcgaatgac 1324 tgaaattacg gggcacctaa taaaaatgag attgggggat ctggaccgag tcaagtcaaa 1384 ggaagcaaaa gaaacagaca aactgagacc cagagacggc actgtgtcta agagcaacag 1444 aaaaagtggt ttgagcagtg tgctcttgat gacagtgttg ctgtgttaaa cgaattaata 1504 catgaaagga cttggaatac tgcttgacat atctttccaa ggcaggaaag ataaagagac 1564 aaagaaagtg ccttgtacag atgcaaacgg aggtgtagac tgtgcagctg ccaaagtggt 1624 gacaagcgat ccagaggacc atgaaaggat cttaatgcaa gtcatgaact tgaatgtgcc 1684 gatgaggcct ggcattcttg tccagagaca gagtaaggaa gtgttggcca cacccttaga 1744 aaacagaagg gacatggagg cagaagagga gaaccaaata aatgagaagc aagagcctga 1804 gaatgctgga gaaactggtc aagaagagga tgatggtttg cagaaaatac acacatctgt 1864 cactagaact ccttcagttg ttgaaagcca aaaaagacct ttaaaaggag tgacattttc 1924 tagggaggta attgttgtgg atcttgggaa tgaataccct acacctcgaa gctatactcg 1984 agaacataaa gagaggaaat gaagctcaaa aaagggtaag agtgaaagaa aatgtaacgt 2044 ttgactaacg ttgaaagact gagggtacaa aatcatgttg aaacaacaaa acaatgggga 2104 attaagcaaa taaagatatt attttacctt tgtgcagaaa ggagtgagcc atgtgcaaaa 2164 ttctgtaagt aaaatactta gagcttgaat ataatttttt aaaaattcaa atctgagttc 2224 aagaaattga ttgtattgcc cttaaaacta tctactcaaa cactgttctg gcatgtgaat 2284 aaagtgattt ttgtttgtac aaat 2308 <210> 202 <211> 222 <212> PRT <213> Homo sapiens <400> 202 Met Met Phe Arg Asp Gln Val Gly Ile Leu Ala Gly Trp Phe Lys Gly 1 5 10 15 Trp Asn Glu Cys Glu Gln Thr Val Ala Leu Leu Ser Leu Leu Lys Arg 20 25 30 Val Thr Arg Thr Gln Ala Arg Phe Leu Gln Leu Cys Leu Glu His Ser 35 40 45 Leu Ala Asp Cys Asn Asp Ile His Leu Leu Glu Ser Glu Ala Asn Ser 50 55 60 Ala Ala Ile Val Ser Gln Trp Gln Gln Glu Ser Lys Glu Lys Val Val 65 70 75 80 Ser Leu Leu Leu Ser His Leu Pro Leu Leu Gln Pro Gly Asn Thr Glu 85 90 95 Ala Lys Ser Glu Tyr Met Arg Leu Leu Gln Lys Val Leu Ala Tyr Ser 100 105 110 Ile Glu Ser Asn Ala Phe Ile Glu Glu Ser Arg Gln Leu Leu Ser Tyr 115 120 125 Ala Leu Ile His Pro Ala Thr Thr Leu Glu Asp Arg Asn Ala Leu Ala 130 135 140 Leu Trp Leu Ser His Leu Glu Glu Arg Leu Ala Ser Gly Phe Arg Ser 145 150 155 160 Arg Pro Glu Pro Ser Tyr His Ser Arg Gln Gly Ser Asp Glu Trp Gly 165 170 175 Gly Pro Ala Glu Leu Gly Pro Gly Glu Ala Gly Pro Gly Trp Gln Asp 180 185 190 Lys Pro Pro Arg Glu Asn Gly His Val Pro Phe His Pro Ser Ser Ser 195 200 205 Val Pro Pro Ala Ile Asn Ser Ile Gly Ser Asn Phe Ser Leu 210 215 220 <210> 203 <211> 1890 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (274)..(768) <400> 203 ccttcagtct cagccgccaa ctccggaggc gcggtgctcg gcccgggagc gcgagcggga 60 ggagcagaga cccgcagccg ggagcccgag cgcgggcgat gcaggctccg cgagcggcac 120 ctgcggctcc tctaagctac gaccgtcgtc tccgcggcag cagcgcgggc cccagcagcc 180 tcggcagcca cagccgctgc agccggggca gcctccgctg ctgtcgcctc ctctgatgcg 240 cttgccctct cccggccccg ggactccggg aga atg tgg gtc cta ggc atc gcg 294 Met Trp Val Leu Gly Ile Ala 1 5 gca act ttt tgc gga ttg ttc ttg ctt cca ggc ttt gcg ctg caa atc 342 Ala Thr Phe Cys Gly Leu Phe Leu Leu Pro Gly Phe Ala Leu Gln Ile 10 15 20 cag tgc tac cag tgt gaa gaa ttc cag ctg aac aac gac tgc tcc tcc 390 Gln Cys Tyr Gln Cys Glu Glu Phe Gln Leu Asn Asn Asp Cys Ser Ser 25 30 35 ccc gag ttc att gtg aat tgc acg gtg aac gtt caa gac atg tgt cag 438 Pro Glu Phe Ile Val Asn Cys Thr Val Asn Val Gln Asp Met Cys Gln 40 45 50 55 aaa gaa gtg atg gag caa agt gcc ggg atc atg tac cgc aag tcc tgt 486 Lys Glu Val Met Glu Gln Ser Ala Gly Ile Met Tyr Arg Lys Ser Cys 60 65 70 gca tca tca gcg gcc tgt ctc atc gcc tct gcc ggg tac cag tcc ttc 534 Ala Ser Ser Ala Ala Cys Leu Ile Ala Ser Ala Gly Tyr Gln Ser Phe 75 80 85 tgc tcc cca ggg aaa ctg aac tca gtt tgc atc agc tgc tgc aac acc 582 Cys Ser Pro Gly Lys Leu Asn Ser Val Cys Ile Ser Cys Cys Asn Thr 90 95 100 cct ctt tgt aac ggg cca agg ccc aag aaa agg gga agt tct gcc tcg 630 Pro Leu Cys Asn Gly Pro Arg Pro Lys Lys Arg Gly Ser Ser Ala Ser 105 110 115 gcc ctc agg cca ggg ctc cgc acc acc atc ctg ttc ctc aaa tta gcc 678 Ala Leu Arg Pro Gly Leu Arg Thr Thr Ile Leu Phe Leu Lys Leu Ala 120 125 130 135 tct tct cgg cac act gct gaa ctg aag gag atg cca ccc cct cct gca 726 Ser Ser Arg His Thr Ala Glu Leu Lys Glu Met Pro Pro Pro Pro Ala 140 145 150 ttg ttc ttc cag ccc tcg ccc cca acc ccc cac ctc cct gag 768 Leu Phe Phe Gln Pro Ser Pro Pro Thr Pro His Leu Pro Glu 155 160 165 tgagtttctt ctgggtgtcc ttttattctg ggtagggagc gggagtccgt gttctctttt 828 gttcctgtgc aaataatgaa agagctcggt aaagcattct gaataaattc agcttgactg 888 aattttcagt atgtacttga aggaaggagg tggagtgaaa gttcaccccc atgtctgtgt 948 aaccggagtc aaggccaggc tggcagagtc agtccttaga agtcactgag gtgggcatct 1008 gccttttgta aagcctccag tgtccattcc atccctgatg ggggcatagt ttgagactgc 1068 agagtgagag tgacgttttc ttagggctgg agggccagtt cccactcaag gctccctcgc 1128 ttgacattca aacttcatgc tcctgaaaac cattctctgc agcagaattg gctggtttcg 1188 cgcctgagtt gggctctagt gactcgagac tcaatgactg ggacttagac tggggctcgg 1248 cctcgctctg aaaagtgctt aagaaaatct tctcagttct cccttgcaga ggactggcgc 1308 cgggacgcga agagcaacgg gcgctgcaca aagcgggcgc tgtcggtggt ggagtgcgca 1368 tgtacgcgca ggcgcttctc gtggttggcg tgctgcagcg acaggcggca gcacagcacc 1428 tgcacgaaca cccgccgaaa ctgctgcgag gacaccgtgt acaggagcgg gttgatgacc 1488 gagctgaggt agaaaaacgt ctccgagaag gggaggagga tcatgtacgc ccggaagtag 1548 gacctcgtcc agtcgtgctt gggtttggcc gcagccatga tcctccgaat ctggttgggc 1608 atccagcata cggccaatgt cacaacaatc agccctgggc agacacgagc aggagggaga 1668 gacagagaaa agaaaaacac agcatgagaa cacagtaaat aaataaaacc ataaaatatt 1728 tagcccctct gttctgtgct tactggccag gaaatggtac caatttttca gtgttggact 1788 tgacagcttc ttttgccaca agcaagagag aatttaacac tgtttcaaac ccgggggagt 1848 tggctgtgtt aaagaaagac cattaaatgc tttagacagt gt 1890 <210> 204 <211> 165 <212> PRT <213> Homo sapiens <400> 204 Met Trp Val Leu Gly Ile Ala Ala Thr Phe Cys Gly Leu Phe Leu Leu 1 5 10 15 Pro Gly Phe Ala Leu Gln Ile Gln Cys Tyr Gln Cys Glu Glu Phe Gln 20 25 30 Leu Asn Asn Asp Cys Ser Ser Pro Glu Phe Ile Val Asn Cys Thr Val 35 40 45 Asn Val Gln Asp Met Cys Gln Lys Glu Val Met Glu Gln Ser Ala Gly 50 55 60 Ile Met Tyr Arg Lys Ser Cys Ala Ser Ser Ala Ala Cys Leu Ile Ala 65 70 75 80 Ser Ala Gly Tyr Gln Ser Phe Cys Ser Pro Gly Lys Leu Asn Ser Val 85 90 95 Cys Ile Ser Cys Cys Asn Thr Pro Leu Cys Asn Gly Pro Arg Pro Lys 100 105 110 Lys Arg Gly Ser Ser Ala Ser Ala Leu Arg Pro Gly Leu Arg Thr Thr 115 120 125 Ile Leu Phe Leu Lys Leu Ala Ser Ser Arg His Thr Ala Glu Leu Lys 130 135 140 Glu Met Pro Pro Pro Pro Ala Leu Phe Phe Gln Pro Ser Pro Pro Thr 145 150 155 160 Pro His Leu Pro Glu 165 <210> 205 <211> 2153 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (176)..(2146) <400> 205 tatgcctggg cagggcgaag ccagaggaaa ctctggtgga ggtccgtagc ggtcctgacg 60 tgcaaatcgg tcgtccgacc tgggtatagg ggcgaaagac taatcgaacc atctagtagc 120 tggttccctc cgaagtttcc ctcaggatag ctggcgctct cgccgccgga ggaag atg 178 Met 1 agg ctg aag att gga ttc atc tta cgc agt ttg ctg gtg gtg gga agc 226 Arg Leu Lys Ile Gly Phe Ile Leu Arg Ser Leu Leu Val Val Gly Ser 5 10 15 ttc ctg ggg cta gtg gtc ctc tgg tct tcc ctg acc ccg cgg ccg gac 274 Phe Leu Gly Leu Val Val Leu Trp Ser Ser Leu Thr Pro Arg Pro Asp 20 25 30 gac cca agc ccg ctg agc agg atg agg gaa gac aga gat gtc aat gac 322 Asp Pro Ser Pro Leu Ser Arg Met Arg Glu Asp Arg Asp Val Asn Asp 35 40 45 ccc atg ccc aac cga ggc ggc aat gga cta gct cct ggg gag gac aga 370 Pro Met Pro Asn Arg Gly Gly Asn Gly Leu Ala Pro Gly Glu Asp Arg 50 55 60 65 ttc aaa cct gtg gta cca tgg cct cat gtt gaa gga gta gaa gtg gac 418 Phe Lys Pro Val Val Pro Trp Pro His Val Glu Gly Val Glu Val Asp 70 75 80 tta gag tct att aga aga ata aac aag gcc aaa aat gaa caa gag cac 466 Leu Glu Ser Ile Arg Arg Ile Asn Lys Ala Lys Asn Glu Gln Glu His 85 90 95 cat gct gga gga gat tcc cag aaa gat atc atg cag agg cag tat ctc 514 His Ala Gly Gly Asp Ser Gln Lys Asp Ile Met Gln Arg Gln Tyr Leu 100 105 110 aca ttt aag cct cag aca ttc acc tac cat gat cct gtg ctt cgc cca 562 Thr Phe Lys Pro Gln Thr Phe Thr Tyr His Asp Pro Val Leu Arg Pro 115 120 125 ggg atc ctc ggt aac ttt gaa ccc aaa gaa cct gag cct cct gga gtg 610 Gly Ile Leu Gly Asn Phe Glu Pro Lys Glu Pro Glu Pro Pro Gly Val 130 135 140 145 gtt ggt ggc cct gga gag aaa gcc aag cca ttg gtt ttg gga cca gaa 658 Val Gly Gly Pro Gly Glu Lys Ala Lys Pro Leu Val Leu Gly Pro Glu 150 155 160 ttc aaa caa gca att caa gcc agc att aaa gag ttt gga ttt aac atg 706 Phe Lys Gln Ala Ile Gln Ala Ser Ile Lys Glu Phe Gly Phe Asn Met 165 170 175 gtg gca agt gac atg atc tca ctg gac cgc agc gtc aat gac tta cgc 754 Val Ala Ser Asp Met Ile Ser Leu Asp Arg Ser Val Asn Asp Leu Arg 180 185 190 caa gaa gaa tgc aag tat tgg cat tat gat gaa aac ttg ctc act tcg 802 Gln Glu Glu Cys Lys Tyr Trp His Tyr Asp Glu Asn Leu Leu Thr Ser 195 200 205 agc gtt gtc att gtc ttc cat aat gaa gga tgg tca acc ctc atg aga 850 Ser Val Val Ile Val Phe His Asn Glu Gly Trp Ser Thr Leu Met Arg 210 215 220 225 aca gtc cac agt gta att aaa agg act cca agg aaa tat tta gca gaa 898 Thr Val His Ser Val Ile Lys Arg Thr Pro Arg Lys Tyr Leu Ala Glu 230 235 240 att gtg tta att gac gat ttc agt aat aaa gaa cac tta aaa gaa aaa 946 Ile Val Leu Ile Asp Asp Phe Ser Asn Lys Glu His Leu Lys Glu Lys 245 250 255 ctg gat gaa tat att aag ctg tgg aat ggc cta gtg aag gta ttt cga 994 Leu Asp Glu Tyr Ile Lys Leu Trp Asn Gly Leu Val Lys Val Phe Arg 260 265 270 aat gaa aga agg gaa ggt tta att caa gca cga agt att ggt gct cag 1042 Asn Glu Arg Arg Glu Gly Leu Ile Gln Ala Arg Ser Ile Gly Ala Gln 275 280 285 aag gct aaa ctt gga cag gtt ttg ata tac ctt gat gcc cac tgt gag 1090 Lys Ala Lys Leu Gly Gln Val Leu Ile Tyr Leu Asp Ala His Cys Glu 290 295 300 305 gtg gca gtt aac tgg tat gca cca ctt gta gct ccc ata tct aag gac 1138 Val Ala Val Asn Trp Tyr Ala Pro Leu Val Ala Pro Ile Ser Lys Asp 310 315 320 aga acc att tgc act gtg ccg ctt ata gat gtc ata aat ggc aac aca 1186 Arg Thr Ile Cys Thr Val Pro Leu Ile Asp Val Ile Asn Gly Asn Thr 325 330 335 tat gaa att ata ccc caa ggg ggt ggt gat gaa gat ggg tat gcc cga 1234 Tyr Glu Ile Ile Pro Gln Gly Gly Gly Asp Glu Asp Gly Tyr Ala Arg 340 345 350 gga gca tgg gat tgg agt atg ctc tgg aaa cgg gtg cct ctg acc cct 1282 Gly Ala Trp Asp Trp Ser Met Leu Trp Lys Arg Val Pro Leu Thr Pro 355 360 365 caa gag aag aga ctg aga aag aca aaa act gaa ccg tat cgg tcc cca 1330 Gln Glu Lys Arg Leu Arg Lys Thr Lys Thr Glu Pro Tyr Arg Ser Pro 370 375 380 385 gcc atg gct ggg gga tta ttt gcc att gaa cga gag ttc ttc ttt gaa 1378 Ala Met Ala Gly Gly Leu Phe Ala Ile Glu Arg Glu Phe Phe Phe Glu 390 395 400 ttg ggt ctc tat gat cca ggt ctc cag att tgg ggt ggt gaa aac ttt 1426 Leu Gly Leu Tyr Asp Pro Gly Leu Gln Ile Trp Gly Gly Glu Asn Phe 405 410 415 gag atc tca tac aag ata tgg cag tgt ggt ggc aaa tta tta ttt gtt 1474 Glu Ile Ser Tyr Lys Ile Trp Gln Cys Gly Gly Lys Leu Leu Phe Val 420 425 430 cct tgt tct cgt gtt gga cat atc tac cgt ctt gag ggc tgg caa gga 1522 Pro Cys Ser Arg Val Gly His Ile Tyr Arg Leu Glu Gly Trp Gln Gly 435 440 445 aat cct ccg ccc att tat gtt ggg tct tct cca act ctg aag aat tat 1570 Asn Pro Pro Pro Ile Tyr Val Gly Ser Ser Pro Thr Leu Lys Asn Tyr 450 455 460 465 gtt aga gtt gtg gag gtt tgg tgg gat gaa tat aaa gac tac ttc tat 1618 Val Arg Val Val Glu Val Trp Trp Asp Glu Tyr Lys Asp Tyr Phe Tyr 470 475 480 gct agt cgt cct gaa tcg cag gca tta cca tat ggg gat ata tcg gag 1666 Ala Ser Arg Pro Glu Ser Gln Ala Leu Pro Tyr Gly Asp Ile Ser Glu 485 490 495 ctg aaa aaa ttt cga gaa gat cac aac tgc aaa agt ttt aag tgg ttc 1714 Leu Lys Lys Phe Arg Glu Asp His Asn Cys Lys Ser Phe Lys Trp Phe 500 505 510 atg gaa gaa ata gct tat gat atc acc tca cac tac cct ttg cca ccc 1762 Met Glu Glu Ile Ala Tyr Asp Ile Thr Ser His Tyr Pro Leu Pro Pro 515 520 525 aaa aat gtt gac tgg gga gaa atc aga ggc ttc gaa act gct tac tgc 1810 Lys Asn Val Asp Trp Gly Glu Ile Arg Gly Phe Glu Thr Ala Tyr Cys 530 535 540 545 att gat agc atg gga aaa aca aat gga ggc ttt gtt gaa cta gga ccc 1858 Ile Asp Ser Met Gly Lys Thr Asn Gly Gly Phe Val Glu Leu Gly Pro 550 555 560 tgc cac agg atg gga ggg aat cag ctt ttc aga atc aat gaa gca aat 1906 Cys His Arg Met Gly Gly Asn Gln Leu Phe Arg Ile Asn Glu Ala Asn 565 570 575 caa ctc atg cag tat gac cag tgt ttg aca aag gga gct gat gga tca 1954 Gln Leu Met Gln Tyr Asp Gln Cys Leu Thr Lys Gly Ala Asp Gly Ser 580 585 590 aaa gtt atg att aca cac tgt aat cta aat gaa ttt aag gaa tgg cag 2002 Lys Val Met Ile Thr His Cys Asn Leu Asn Glu Phe Lys Glu Trp Gln 595 600 605 tac ttc aag aac ctg cac aga ttt act cat att cct tca gga aag tgt 2050 Tyr Phe Lys Asn Leu His Arg Phe Thr His Ile Pro Ser Gly Lys Cys 610 615 620 625 tta gat cgc tca gag gtc ctg cat caa gta ttc atc tcc aat tgt gac 2098 Leu Asp Arg Ser Glu Val Leu His Gln Val Phe Ile Ser Asn Cys Asp 630 635 640 tcc agt aaa acg act caa aaa tgg gaa atg aat aac atc cat agt gtt 2146 Ser Ser Lys Thr Thr Gln Lys Trp Glu Met Asn Asn Ile His Ser Val 645 650 655 tagagag 2153 <210> 206 <211> 657 <212> PRT <213> Homo sapiens <400> 206 Met Arg Leu Lys Ile Gly Phe Ile Leu Arg Ser Leu Leu Val Val Gly 1 5 10 15 Ser Phe Leu Gly Leu Val Val Leu Trp Ser Ser Leu Thr Pro Arg Pro 20 25 30 Asp Asp Pro Ser Pro Leu Ser Arg Met Arg Glu Asp Arg Asp Val Asn 35 40 45 Asp Pro Met Pro Asn Arg Gly Gly Asn Gly Leu Ala Pro Gly Glu Asp 50 55 60 Arg Phe Lys Pro Val Val Pro Trp Pro His Val Glu Gly Val Glu Val 65 70 75 80 Asp Leu Glu Ser Ile Arg Arg Ile Asn Lys Ala Lys Asn Glu Gln Glu 85 90 95 His His Ala Gly Gly Asp Ser Gln Lys Asp Ile Met Gln Arg Gln Tyr 100 105 110 Leu Thr Phe Lys Pro Gln Thr Phe Thr Tyr His Asp Pro Val Leu Arg 115 120 125 Pro Gly Ile Leu Gly Asn Phe Glu Pro Lys Glu Pro Glu Pro Pro Gly 130 135 140 Val Val Gly Gly Pro Gly Glu Lys Ala Lys Pro Leu Val Leu Gly Pro 145 150 155 160 Glu Phe Lys Gln Ala Ile Gln Ala Ser Ile Lys Glu Phe Gly Phe Asn 165 170 175 Met Val Ala Ser Asp Met Ile Ser Leu Asp Arg Ser Val Asn Asp Leu 180 185 190 Arg Gln Glu Glu Cys Lys Tyr Trp His Tyr Asp Glu Asn Leu Leu Thr 195 200 205 Ser Ser Val Val Ile Val Phe His Asn Glu Gly Trp Ser Thr Leu Met 210 215 220 Arg Thr Val His Ser Val Ile Lys Arg Thr Pro Arg Lys Tyr Leu Ala 225 230 235 240 Glu Ile Val Leu Ile Asp Asp Phe Ser Asn Lys Glu His Leu Lys Glu 245 250 255 Lys Leu Asp Glu Tyr Ile Lys Leu Trp Asn Gly Leu Val Lys Val Phe 260 265 270 Arg Asn Glu Arg Arg Glu Gly Leu Ile Gln Ala Arg Ser Ile Gly Ala 275 280 285 Gln Lys Ala Lys Leu Gly Gln Val Leu Ile Tyr Leu Asp Ala His Cys 290 295 300 Glu Val Ala Val Asn Trp Tyr Ala Pro Leu Val Ala Pro Ile Ser Lys 305 310 315 320 Asp Arg Thr Ile Cys Thr Val Pro Leu Ile Asp Val Ile Asn Gly Asn 325 330 335 Thr Tyr Glu Ile Ile Pro Gln Gly Gly Gly Asp Glu Asp Gly Tyr Ala 340 345 350 Arg Gly Ala Trp Asp Trp Ser Met Leu Trp Lys Arg Val Pro Leu Thr 355 360 365 Pro Gln Glu Lys Arg Leu Arg Lys Thr Lys Thr Glu Pro Tyr Arg Ser 370 375 380 Pro Ala Met Ala Gly Gly Leu Phe Ala Ile Glu Arg Glu Phe Phe Phe 385 390 395 400 Glu Leu Gly Leu Tyr Asp Pro Gly Leu Gln Ile Trp Gly Gly Glu Asn 405 410 415 Phe Glu Ile Ser Tyr Lys Ile Trp Gln Cys Gly Gly Lys Leu Leu Phe 420 425 430 Val Pro Cys Ser Arg Val Gly His Ile Tyr Arg Leu Glu Gly Trp Gln 435 440 445 Gly Asn Pro Pro Pro Ile Tyr Val Gly Ser Ser Pro Thr Leu Lys Asn 450 455 460 Tyr Val Arg Val Val Glu Val Trp Trp Asp Glu Tyr Lys Asp Tyr Phe 465 470 475 480 Tyr Ala Ser Arg Pro Glu Ser Gln Ala Leu Pro Tyr Gly Asp Ile Ser 485 490 495 Glu Leu Lys Lys Phe Arg Glu Asp His Asn Cys Lys Ser Phe Lys Trp 500 505 510 Phe Met Glu Glu Ile Ala Tyr Asp Ile Thr Ser His Tyr Pro Leu Pro 515 520 525 Pro Lys Asn Val Asp Trp Gly Glu Ile Arg Gly Phe Glu Thr Ala Tyr 530 535 540 Cys Ile Asp Ser Met Gly Lys Thr Asn Gly Gly Phe Val Glu Leu Gly 545 550 555 560 Pro Cys His Arg Met Gly Gly Asn Gln Leu Phe Arg Ile Asn Glu Ala 565 570 575 Asn Gln Leu Met Gln Tyr Asp Gln Cys Leu Thr Lys Gly Ala Asp Gly 580 585 590 Ser Lys Val Met Ile Thr His Cys Asn Leu Asn Glu Phe Lys Glu Trp 595 600 605 Gln Tyr Phe Lys Asn Leu His Arg Phe Thr His Ile Pro Ser Gly Lys 610 615 620 Cys Leu Asp Arg Ser Glu Val Leu His Gln Val Phe Ile Ser Asn Cys 625 630 635 640 Asp Ser Ser Lys Thr Thr Gln Lys Trp Glu Met Asn Asn Ile His Ser 645 650 655 Val <210> 207 <211> 2031 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (202)..(1554) <400> 207 ttggagcaag cggcggcggc ggagacagag gcagaggcag aagctggggc tccgtcctcg 60 cctcccacga gcgatccccg aggagagccg cggccctcgg cgaggcgaag aggccgacga 120 ggaagacccg ggtggctgcg cccctgcctc gcttcccagg cgccggcggc tgcagccttg 180 cccctcttgc tcgccttgaa a atg gaa aag atg ctc gca ggc tgc ttt ctg 231 Met Glu Lys Met Leu Ala Gly Cys Phe Leu 1 5 10 ctg atc ctc gga cag atc gtc ctc ctc cct gcc gag gcc agg gag cgg 279 Leu Ile Leu Gly Gln Ile Val Leu Leu Pro Ala Glu Ala Arg Glu Arg 15 20 25 tca cgt ggg agg tcc atc tct agg ggc aga cac gct cgg acc cac ccg 327 Ser Arg Gly Arg Ser Ile Ser Arg Gly Arg His Ala Arg Thr His Pro 30 35 40 cag acg gcc ctt ctg gag agt tcc tgt gag aac aag cgg gca gac ctg 375 Gln Thr Ala Leu Leu Glu Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu 45 50 55 gtt ttc atc att gac agc tct cgc agt gtc aac acc cat gac tat gca 423 Val Phe Ile Ile Asp Ser Ser Arg Ser Val Asn Thr His Asp Tyr Ala 60 65 70 aag gtc aag gag ttc atc gtg gac atc ttg caa ttc ttg gac att ggt 471 Lys Val Lys Glu Phe Ile Val Asp Ile Leu Gln Phe Leu Asp Ile Gly 75 80 85 90 cct gat gtc acc cga gtg ggc ctg ctc caa tat ggc agc act gtc aag 519 Pro Asp Val Thr Arg Val Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys 95 100 105 aat gag ttc tcc ctc aag acc ttc aag agg aag tcc gag gtg gag cgt 567 Asn Glu Phe Ser Leu Lys Thr Phe Lys Arg Lys Ser Glu Val Glu Arg 110 115 120 gct gtc aag agg atg cgg cat ccg tcc acg ggc acc atg act ggg ctg 615 Ala Val Lys Arg Met Arg His Pro Ser Thr Gly Thr Met Thr Gly Leu 125 130 135 gcc atc cag tat gcc ctg aac atc gca ttc tca gaa gca gag ggg gcc 663 Ala Ile Gln Tyr Ala Leu Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala 140 145 150 cgg ccc ctg agg gag aat gtg cca cgg gtc ata atg atc gtg aca gat 711 Arg Pro Leu Arg Glu Asn Val Pro Arg Val Ile Met Ile Val Thr Asp 155 160 165 170 ggg aga cct cag gac tcc gtg gcc gag gtg gct gct aag gca cgg gac 759 Gly Arg Pro Gln Asp Ser Val Ala Glu Val Ala Ala Lys Ala Arg Asp 175 180 185 acg ggc atc cta atc ttt gcc att ggt gtg ggc cag gta gac ttc aac 807 Thr Gly Ile Leu Ile Phe Ala Ile Gly Val Gly Gln Val Asp Phe Asn 190 195 200 acc ttg aag tcc att ggg agt gag ccc cat gag gac cat gtc ttc ctt 855 Thr Leu Lys Ser Ile Gly Ser Glu Pro His Glu Asp His Val Phe Leu 205 210 215 gtg gcc aat ttc agc cag att gag acg ctg acc tcc gtg ttc cag aag 903 Val Ala Asn Phe Ser Gln Ile Glu Thr Leu Thr Ser Val Phe Gln Lys 220 225 230 aag ttg tgc acg gcc cat atg tgc agc acc ctg gag cat aac tgt gcc 951 Lys Leu Cys Thr Ala His Met Cys Ser Thr Leu Glu His Asn Cys Ala 235 240 245 250 cac ttc tgc atc aac atc cct ggc tca tac gtc tgc agg tgc aaa caa 999 His Phe Cys Ile Asn Ile Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln 255 260 265 ggc tac att ctc aac tcg gat cag acg act tgc aga atc cag gat ctg 1047 Gly Tyr Ile Leu Asn Ser Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu 270 275 280 tgt gcc atg gag gac cac aac tgt gag cag ctc tgt gtg aat gtg ccg 1095 Cys Ala Met Glu Asp His Asn Cys Glu Gln Leu Cys Val Asn Val Pro 285 290 295 ggc tcc ttc gtc tgc cag tgc tac agt ggc tac gcc ctg gct gag gat 1143 Gly Ser Phe Val Cys Gln Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp 300 305 310 ggg aag agg tgt gtg gct gtg gac tac tgt gcc tca gaa aac cac gga 1191 Gly Lys Arg Cys Val Ala Val Asp Tyr Cys Ala Ser Glu Asn His Gly 315 320 325 330 tgt gaa cat gag tgt gta aat gct gat ggc tcc tac ctt tgc cag tgc 1239 Cys Glu His Glu Cys Val Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys 335 340 345 cat gag gga ttt gct ctt aac cca gat aaa aaa acg tgc aca aag ata 1287 His Glu Gly Phe Ala Leu Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile 350 355 360 gac tac tgt gcc tca tct aat cac gga tgt cag cac gag tgt gtt aac 1335 Asp Tyr Cys Ala Ser Ser Asn His Gly Cys Gln His Glu Cys Val Asn 365 370 375 aca gat gat tcc tat tcc tgc cac tgc ctg aaa ggc ttt acc ctg aat 1383 Thr Asp Asp Ser Tyr Ser Cys His Cys Leu Lys Gly Phe Thr Leu Asn 380 385 390 cca gat aag aaa acc tgc aga agg atc aac tac tgt gca ctg aac aaa 1431 Pro Asp Lys Lys Thr Cys Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys 395 400 405 410 ccg ggc tgt gag cat gag tgc gtc aac atg gag gag agc tac tac tgc 1479 Pro Gly Cys Glu His Glu Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys 415 420 425 cgc tgc cac cgt ggc tac act ctg gac ccc aat ggc aaa acc tgc agc 1527 Arg Cys His Arg Gly Tyr Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser 430 435 440 cgt gag tgt acc cta ggg gtg ggg tgc tgatggaagg tggggtccac 1574 Arg Glu Cys Thr Leu Gly Val Gly Cys 445 450 tcatgggggc gggcgggttc actagcaacc agttatttct ggagcccacc gggtttcctg 1634 atggtctgtc aggtgtatcc ttccttatcc tcagtttcat cacccataga atgtgactat 1694 taatgctatc ggcctagcca acttgggttg caaggattaa aagaattaat aggaataggc 1754 tgggcgcggt ggctcacgcc tgtaatccca gcacagggag gccaaggcgg gcagatcacc 1814 tgaggtcagg agttcaagac cagcctggcc aacatggtga aaccctatct ctactaaaaa 1874 tacaaaaaat tagctgggtg tggtggtggg tgcctataat cccagctact cgggaggctg 1934 aagcaggaga attactcgaa cctaggaggc agaggtgcag tgagctgaga ttgcgccatt 1994 gcactccaac ctgggcgaca aagcaaaact tcatctc 2031 <210> 208 <211> 451 <212> PRT <213> Homo sapiens <400> 208 Met Glu Lys Met Leu Ala Gly Cys Phe Leu Leu Ile Leu Gly Gln Ile 1 5 10 15 Val Leu Leu Pro Ala Glu Ala Arg Glu Arg Ser Arg Gly Arg Ser Ile 20 25 30 Ser Arg Gly Arg His Ala Arg Thr His Pro Gln Thr Ala Leu Leu Glu 35 40 45 Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser 50 55 60 Ser Arg Ser Val Asn Thr His Asp Tyr Ala Lys Val Lys Glu Phe Ile 65 70 75 80 Val Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val 85 90 95 Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys 100 105 110 Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg 115 120 125 His Pro Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu 130 135 140 Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn 145 150 155 160 Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser 165 170 175 Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe 180 185 190 Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly 195 200 205 Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln 210 215 220 Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His 225 230 235 240 Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile 245 250 255 Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser 260 265 270 Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu Asp His 275 280 285 Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln 290 295 300 Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala 305 310 315 320 Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val 325 330 335 Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu 340 345 350 Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser Ser 355 360 365 Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser Tyr Ser 370 375 380 Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys 385 390 395 400 Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu 405 410 415 Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg Gly Tyr 420 425 430 Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Glu Cys Thr Leu Gly 435 440 445 Val Gly Cys 450 <210> 209 <211> 1841 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (51)..(632) <400> 209 tgttttgttt ctttatttgg acttaacggc cactcatttc tgttggcgcc atg cga 56 Met Arg 1 ctg ttg ccg tgt gca gca ggg acc tct gcc ttc ctc tcc tcc cag ctc 104 Leu Leu Pro Cys Ala Ala Gly Thr Ser Ala Phe Leu Ser Ser Gln Leu 5 10 15 aca ata ggt gcc tct tcc tcc tcc cgg cca tcc acg ccg gcc tgg ttt 152 Thr Ile Gly Ala Ser Ser Ser Ser Arg Pro Ser Thr Pro Ala Trp Phe 20 25 30 tcg gtt ctg gaa tac atc caa ccc ttt cgt tcg tgt tct ttt ctc ctg 200 Ser Val Leu Glu Tyr Ile Gln Pro Phe Arg Ser Cys Ser Phe Leu Leu 35 40 45 50 tca tct tct ccg cct gga gct ctt cca tgt tct ctt tgc aca agc gac 248 Ser Ser Ser Pro Pro Gly Ala Leu Pro Cys Ser Leu Cys Thr Ser Asp 55 60 65 tct atc ctt cca gtt tca gat gat ttc acc tcc tca aag agg cct ttg 296 Ser Ile Leu Pro Val Ser Asp Asp Phe Thr Ser Ser Lys Arg Pro Leu 70 75 80 gga cca gcc ttt tct aaa gct ttc ctt gag aat gct ggt caa gat tta 344 Gly Pro Ala Phe Ser Lys Ala Phe Leu Glu Asn Ala Gly Gln Asp Leu 85 90 95 cct ttt aat ttt gtt ttt tct gtt tgt tct gtc tcc tct gcc ggc tgc 392 Pro Phe Asn Phe Val Phe Ser Val Cys Ser Val Ser Ser Ala Gly Cys 100 105 110 ttg agc tcc agg atc aca gag gac atg agt gtt ctg ttc cca ctg atg 440 Leu Ser Ser Arg Ile Thr Glu Asp Met Ser Val Leu Phe Pro Leu Met 115 120 125 130 cct ggt gcc aga ctg gga cac gtg tgc tca gcc atg gct aat gtg cgc 488 Pro Gly Ala Arg Leu Gly His Val Cys Ser Ala Met Ala Asn Val Arg 135 140 145 agg cag gga tgg tca cac agt ggc ctc ttg gcg ctc tgg ccg agt ggg 536 Arg Gln Gly Trp Ser His Ser Gly Leu Leu Ala Leu Trp Pro Ser Gly 150 155 160 agg agc aag ggg agg agc tgt cag aag gag acc tgc cta gtc aca ggc 584 Arg Ser Lys Gly Arg Ser Cys Gln Lys Glu Thr Cys Leu Val Thr Gly 165 170 175 agg tca cag ggc ttc cag aat ccc att cag gtg atc ccc tcc tgg tgg 632 Arg Ser Gln Gly Phe Gln Asn Pro Ile Gln Val Ile Pro Ser Trp Trp 180 185 190 taaacagcac acctcagaag tggtgttttg tcatagttgt tcttatggct cccacagcct 692 catctctgtt ttgtccattt gggattgagg agttgttgag tccagcgtca ccttcagagc 752 cagtgcactc cttatcaata gtgagggccg ctcgttttga ttgttccgtt tcgcttgata 812 aagctgagtg agaattatat tggccaacag aaacgtctct ctccatgtga acacagccac 872 tgggtcacca gggacgtggc ttacagttcc agcaggctcc tgtcacactg gtgcctttgg 932 gcagtacaga actgtgctgc tggtggtgac gtccggggct gtgcagtgtc gcttcctttt 992 gcatatgttg ctattggtgt catttcctct ctgagatcag tggaagtctc aggtcagtcc 1052 cgtggccctg tattgcttag tgggccatgt gtttaaactt ccaaaaggca tattttaaat 1112 agttattgga gtgttgatgt gaagagctcc tttgataatg tattttcttt gtagaaattt 1172 aaaagcctgt tgattcaaga actttctaaa gtatttccgg aagacatggc taagtatcga 1232 agcatccggg gggaggatca cccgccttct taaccagctc accctccctg tgtgaagatc 1292 ccctgggact gcgatgcggc gtgaggctgg gactgcgagt gctgacgcca ccttcctgct 1352 gaggtgggac tgggccctgg acacacccct cagcccctct gtcctcattg tttggcctca 1412 tgggaccgag gggctggagg agaggcggag ctgtgcccca gctgttccag cagcttgtct 1472 ggcgtcaact ggctttcaga gtgctgaccc ctcatcactg tggggatcat tctctctgag 1532 ggcagatgag gcgcaggaaa atagtcttgg aaatgttaaa tatgatgggt aaattaaaag 1592 ttttacaaca ttctacctaa tatttttctt ttaacatact ctttctgttc tattgtatta 1652 tggtgtccga aagctaaata acgactagga aaaatttttt taaaaaaaga aaaatcagtt 1712 taatgtggga agtacttaag tggtattata ttttacattt tcaagtatag tgcataaaga 1772 atgttttaaa tgtaactgtt ttcatggatt tcaattagac atgcctataa taaactaagt 1832 atgtggctt 1841 <210> 210 <211> 194 <212> PRT <213> Homo sapiens <400> 210 Met Arg Leu Leu Pro Cys Ala Ala Gly Thr Ser Ala Phe Leu Ser Ser 1 5 10 15 Gln Leu Thr Ile Gly Ala Ser Ser Ser Ser Arg Pro Ser Thr Pro Ala 20 25 30 Trp Phe Ser Val Leu Glu Tyr Ile Gln Pro Phe Arg Ser Cys Ser Phe 35 40 45 Leu Leu Ser Ser Ser Pro Pro Gly Ala Leu Pro Cys Ser Leu Cys Thr 50 55 60 Ser Asp Ser Ile Leu Pro Val Ser Asp Asp Phe Thr Ser Ser Lys Arg 65 70 75 80 Pro Leu Gly Pro Ala Phe Ser Lys Ala Phe Leu Glu Asn Ala Gly Gln 85 90 95 Asp Leu Pro Phe Asn Phe Val Phe Ser Val Cys Ser Val Ser Ser Ala 100 105 110 Gly Cys Leu Ser Ser Arg Ile Thr Glu Asp Met Ser Val Leu Phe Pro 115 120 125 Leu Met Pro Gly Ala Arg Leu Gly His Val Cys Ser Ala Met Ala Asn 130 135 140 Val Arg Arg Gln Gly Trp Ser His Ser Gly Leu Leu Ala Leu Trp Pro 145 150 155 160 Ser Gly Arg Ser Lys Gly Arg Ser Cys Gln Lys Glu Thr Cys Leu Val 165 170 175 Thr Gly Arg Ser Gln Gly Phe Gln Asn Pro Ile Gln Val Ile Pro Ser 180 185 190 Trp Trp <210> 211 <211> 1493 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (77)..(1492) <400> 211 acagccgacg aggcaacaat taggctttgg ggataaaacg aggtgcggag agcgggctgg 60 ggcatttctc cccgag atg gcg ggt ctg acg gcg gcg gcc ccg cgg ccc gga 112 Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly 1 5 10 gtc ctc ctg ctc ctg ctg tcc atc ctc cac ccc tct cgg cct gga ggg 160 Val Leu Leu Leu Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly 15 20 25 gtc cct ggg gcc att cct ggt gga gtt cct gga gga gtc ttt tat cca 208 Val Pro Gly Ala Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro 30 35 40 ggg gct ggt ctc gga gcc ctt gga gga gga gcg ctg ggg cct gga ggc 256 Gly Ala Gly Leu Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly 45 50 55 60 aaa cct ctt aag cca gtt ccc gga ggg ctt gcg ggt gct ggc ctt ggg 304 Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly 65 70 75 gca ggg ctc ggg gct ctc ggt gga gta ggc atc cca ggc ggt gtg gtg 352 Ala Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val 80 85 90 gga gcc gga ccc gcc gcc gcc gct gcc gca gcc gct aag gca gcc aag 400 Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys 95 100 105 tat gga gct gct gca ggc tta gtg cct ggt ggg cca ggc ttt ggc ccg 448 Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro 110 115 120 gga gta gtt ggt gtc cca gga gct ggc gtt cca ggt gtt ggt gtc cca 496 Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro 125 130 135 140 gga gct ggg att cca gtt gtc cca ggt gct ggg atc cca ggt gct gcg 544 Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala 145 150 155 gtt cca ggg gtt gtg tca cca gaa gca gct gct aag gca gct gca aag 592 Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys 160 165 170 gca gcc aaa tac ggg gcc agg ccc gga gtc gga gtt gga ggc att cct 640 Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro 175 180 185 act tac ggg gtt gga gct ggg ggc ttt ccc ggc ttt ggt gtc gga gtc 688 Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val 190 195 200 gga ggt atc cct gga gtc gca ggt gtc cct ggt gtc gga ggt gtt ccc 736 Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro 205 210 215 220 gga gtc gga ggt gtc ccg gga gtt ggc att tcc ccc gaa gct cag gca 784 Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala 225 230 235 gca gct gcc gcc aag gct gcc aag tac ggg tta gtt cct ggt gtc ggc 832 Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly 240 245 250 gtg gct cct gga gtt ggc gtg gct cct ggt gtc ggt gtg gct cct gga 880 Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 255 260 265 gtt ggc ttg gct cct gga gtt ggc gtg gct cct gga gtt ggt gtg gct 928 Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala 270 275 280 cct ggc gtt ggc gtg gct ccc ggc att ggc cct ggt gga gtt gca gct 976 Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala 285 290 295 300 gca gca aaa tcc gct gcc aag gtg gct gcc aaa gcc cag ctc cga gct 1024 Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala 305 310 315 gca gct ggg ctt ggt gct ggc atc cct gga ctt gga gtt ggt gtc ggc 1072 Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly 320 325 330 gtc cct gga ctt gga gtt ggt act ggt gtt cct gga ctt gga gtt ggt 1120 Val Pro Gly Leu Gly Val Gly Thr Gly Val Pro Gly Leu Gly Val Gly 335 340 345 gct ggt gtt cct ggc ttc ggg gca gta cct ggt gcc ctg gct gcc gct 1168 Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala 350 355 360 aaa gca gcc aaa tat gga gca gca gtg cct ggg gtc ctt gga ggg ctc 1216 Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu 365 370 375 380 ggg gct ctc ggt gga gta ggc atc aac ctg gtt gac ctg tca tgg ccg 1264 Gly Ala Leu Gly Gly Val Gly Ile Asn Leu Val Asp Leu Ser Trp Pro 385 390 395 cct gtg ccc tgc ctc cac ccc cat cct ata ctc ccc cag ggc gtg cgg 1312 Pro Val Pro Cys Leu His Pro His Pro Ile Leu Pro Gln Gly Val Arg 400 405 410 ggc tgt gca gac tgg ggt gcc agg cat ctc ctc ccc acc cgg ggt gtc 1360 Gly Cys Ala Asp Trp Gly Ala Arg His Leu Leu Pro Thr Arg Gly Val 415 420 425 ccc aca tgc agt act gta tac ccc cca tcc ctc cct cgg tcc act gaa 1408 Pro Thr Cys Ser Thr Val Tyr Pro Pro Ser Leu Pro Arg Ser Thr Glu 430 435 440 ctt cag agc agt tcc cat tcc tgc ccc gcc cat ctt ttt gtg tct cgc 1456 Leu Gln Ser Ser Ser His Ser Cys Pro Ala His Leu Phe Val Ser Arg 445 450 455 460 tgt gat aga tca ata aat att tta ttt ttt gtc ctg g 1493 Cys Asp Arg Ser Ile Asn Ile Leu Phe Phe Val Leu 465 470 <210> 212 <211> 472 <212> PRT <213> Homo sapiens <400> 212 Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 1 5 10 15 Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 20 25 30 Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 35 40 45 Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 50 55 60 Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 65 70 75 80 Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro 85 90 95 Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala 100 105 110 Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly 115 120 125 Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile 130 135 140 Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val 145 150 155 160 Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr 165 170 175 Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val 180 185 190 Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro 195 200 205 Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly 210 215 220 Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala 225 230 235 240 Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly Val Ala Pro Gly 245 250 255 Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu Ala 260 265 270 Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 275 280 285 Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala Lys Ser 290 295 300 Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala Gly Leu 305 310 315 320 Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro Gly Leu 325 330 335 Gly Val Gly Thr Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro 340 345 350 Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala Ala Lys 355 360 365 Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala Leu Gly 370 375 380 Gly Val Gly Ile Asn Leu Val Asp Leu Ser Trp Pro Pro Val Pro Cys 385 390 395 400 Leu His Pro His Pro Ile Leu Pro Gln Gly Val Arg Gly Cys Ala Asp 405 410 415 Trp Gly Ala Arg His Leu Leu Pro Thr Arg Gly Val Pro Thr Cys Ser 420 425 430 Thr Val Tyr Pro Pro Ser Leu Pro Arg Ser Thr Glu Leu Gln Ser Ser 435 440 445 Ser His Ser Cys Pro Ala His Leu Phe Val Ser Arg Cys Asp Arg Ser 450 455 460 Ile Asn Ile Leu Phe Phe Val Leu 465 470 <210> 213 <211> 1557 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (137)..(595) <400> 213 aactacacca gggccggtgc acctcggggc ggcggcgcag gactaggctc ggcctcccag 60 cgctcccaag ccgcagcggc cgcgcccctt cagctagctc gctcgctcgc tctgcttccc 120 tgctgccggc tgcgcc atg gcg ttg gcg ttg gcg gcg ctg gcg gcg gtc gag 172 Met Ala Leu Ala Leu Ala Ala Leu Ala Ala Val Glu 1 5 10 ccg gcc tgc ggc agc cgg tac cag cag ttg cag aat gaa gaa gag tct 220 Pro Ala Cys Gly Ser Arg Tyr Gln Gln Leu Gln Asn Glu Glu Glu Ser 15 20 25 gga gaa cct gaa cag gct gca ggt gat gct cct cca cct tac agc agc 268 Gly Glu Pro Glu Gln Ala Ala Gly Asp Ala Pro Pro Pro Tyr Ser Ser 30 35 40 att tct gca gag agc gca gca tat ttt gac tac aag gat gag tct ggg 316 Ile Ser Ala Glu Ser Ala Ala Tyr Phe Asp Tyr Lys Asp Glu Ser Gly 45 50 55 60 ttt cca aag ccc cca tct tac aat gta gct aca aca ctg ccc agt tgt 364 Phe Pro Lys Pro Pro Ser Tyr Asn Val Ala Thr Thr Leu Pro Ser Cys 65 70 75 ttt tat gat atc agc cat ttg att ttt ttc att ttc tat tta aga aat 412 Phe Tyr Asp Ile Ser His Leu Ile Phe Phe Ile Phe Tyr Leu Arg Asn 80 85 90 atg aag aaa aaa tac acc aag atg gtc aaa tta cta cac aaa tca gca 460 Met Lys Lys Lys Tyr Thr Lys Met Val Lys Leu Leu His Lys Ser Ala 95 100 105 cca gca cag tct gat agc tgc aaa tgt cca ttc atc tgc tgt gta tgt 508 Pro Ala Gln Ser Asp Ser Cys Lys Cys Pro Phe Ile Cys Cys Val Cys 110 115 120 ata tcc aga atc agc ata gga agt cgt tca gga tat cag tat ata atg 556 Ile Ser Arg Ile Ser Ile Gly Ser Arg Ser Gly Tyr Gln Tyr Ile Met 125 130 135 140 cac aga agt gtg ggt tgt ttg aaa gcc aaa cag gaa aat taggagcctc 605 His Arg Ser Val Gly Cys Leu Lys Ala Lys Gln Glu Asn 145 150 ctggattgac atttcagtga tccctctaac cagtttatgg attattatga ataatagtgt 665 agtatgttct ttttcagaag ttatatttga taatagagaa gggagtttta tggaagtttc 725 tttgaagatt tttttttttt ccatttcgaa tcagattata gcaacaatgg agtttggaag 785 tttgtatggc ctataatgtt ctaagttcca gaatgaaaag atctgtaaca atctgaatag 845 atgtggacac atatagcaga gagaactatg taaattatct tgcagaacaa aatagaaggg 905 tcctaaatca cgttaactca aacattgtag actagctttg tgtttattct tcaggtcctt 965 gcgccttatt tggttttgta tattcaacga actgaaatat ttggaattcc tatttctacg 1025 tatttggtgg tccataagac tttgtcaaat gtaaacctac agtttgataa gctttaaaat 1085 acctagttaa gaggatgatt tctctttaat cgtttaaatg ttctgaaaat taaaatcttt 1145 tgaggcacat gaagtgggca ccatatatca tctagagtcc ttactggtat tcaggatgaa 1205 aatgttcacg ctgcattaat tgtcattttt ctctcccatg ttctttctca ctttgatacg 1265 ttaatactga taatggataa agagtgagtt tttataataa atggttttgg aaaggtattc 1325 ataggaaccg cggttattta cttaaggtta tggagtaaac tagcttggac cttgggctgc 1385 aggacgacta ggattcaccc ataacgacac agtgccctat gtttcttaac ttcttgttgc 1445 catttgaagc tctgtactct tatgtttaaa gggttttgta tagccatttt ttttttcaga 1505 aagttacatt gctttgtata gaaataaaag gcattattaa aatttgcttg tt 1557 <210> 214 <211> 153 <212> PRT <213> Homo sapiens <400> 214 Met Ala Leu Ala Leu Ala Ala Leu Ala Ala Val Glu Pro Ala Cys Gly 1 5 10 15 Ser Arg Tyr Gln Gln Leu Gln Asn Glu Glu Glu Ser Gly Glu Pro Glu 20 25 30 Gln Ala Ala Gly Asp Ala Pro Pro Pro Tyr Ser Ser Ile Ser Ala Glu 35 40 45 Ser Ala Ala Tyr Phe Asp Tyr Lys Asp Glu Ser Gly Phe Pro Lys Pro 50 55 60 Pro Ser Tyr Asn Val Ala Thr Thr Leu Pro Ser Cys Phe Tyr Asp Ile 65 70 75 80 Ser His Leu Ile Phe Phe Ile Phe Tyr Leu Arg Asn Met Lys Lys Lys 85 90 95 Tyr Thr Lys Met Val Lys Leu Leu His Lys Ser Ala Pro Ala Gln Ser 100 105 110 Asp Ser Cys Lys Cys Pro Phe Ile Cys Cys Val Cys Ile Ser Arg Ile 115 120 125 Ser Ile Gly Ser Arg Ser Gly Tyr Gln Tyr Ile Met His Arg Ser Val 130 135 140 Gly Cys Leu Lys Ala Lys Gln Glu Asn 145 150 <210> 215 <211> 3555 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (271)..(1998) <400> 215 gaccccggcg cgcgcgcggc ggaggacgag gaagagttgt ggcgaggcag atcctgcccc 60 gtggccgcgg ccgtctcgtg tcccaccggc cttccgggtt ccagcgccag gcctggtgcc 120 tgccccagga ggatgagcat ttgcattgcc tgcaccttat cgtgcccttc cacctgctga 180 agcagctgtg cctgccgctc ttgtgaactg cgaacttccc cttacctcct ctctctggct 240 cgggagctgg ctcggccgcc tgtcagtgca atg ctg ccc cat gtg gtg ctc acc 294 Met Leu Pro His Val Val Leu Thr 1 5 ttc cgg cgc ctg ggc tgc gcc ttg gcg tcc tgc cgg ctg gcg cct gcg 342 Phe Arg Arg Leu Gly Cys Ala Leu Ala Ser Cys Arg Leu Ala Pro Ala 10 15 20 aga cac aga gga agt ggt ctt ctg cac aca gcc cca gtg gcc cgc tcg 390 Arg His Arg Gly Ser Gly Leu Leu His Thr Ala Pro Val Ala Arg Ser 25 30 35 40 gac agg agc gcc ccg gtg ttc acc cgt gcc ctg gcc ttt ggg gac aga 438 Asp Arg Ser Ala Pro Val Phe Thr Arg Ala Leu Ala Phe Gly Asp Arg 45 50 55 atc gcc ctg gtt gac cag cac ggc cgc cac acg tac agg gag ctt tat 486 Ile Ala Leu Val Asp Gln His Gly Arg His Thr Tyr Arg Glu Leu Tyr 60 65 70 tcc cgc agc ctt cgc ctg tcc cag gag atc tgc agg ctc tgc ggg tgt 534 Ser Arg Ser Leu Arg Leu Ser Gln Glu Ile Cys Arg Leu Cys Gly Cys 75 80 85 gtc ggc ggg gac ctc cgg gag gag agg gtc tcc ttc cta tgc gct aac 582 Val Gly Gly Asp Leu Arg Glu Glu Arg Val Ser Phe Leu Cys Ala Asn 90 95 100 gat gcc tcc tac gtc gtg gcc cag tgg gcg tca tgg atg agt ggc ggt 630 Asp Ala Ser Tyr Val Val Ala Gln Trp Ala Ser Trp Met Ser Gly Gly 105 110 115 120 gtg gca gtc ccc ctc tac agg aag cat ccc gcg gcc cag ctg gag tat 678 Val Ala Val Pro Leu Tyr Arg Lys His Pro Ala Ala Gln Leu Glu Tyr 125 130 135 gtc atc tgc gac tcc cag agc tct gtg gtc ctt gcc agc cag gag tac 726 Val Ile Cys Asp Ser Gln Ser Ser Val Val Leu Ala Ser Gln Glu Tyr 140 145 150 ctg gag ctc ctg agc ccg gtg gtc agg aag ctg ggg gtc ccg ctg ctg 774 Leu Glu Leu Leu Ser Pro Val Val Arg Lys Leu Gly Val Pro Leu Leu 155 160 165 ccg ctc aca cca gcc atc tac act gga gca gta gag gaa ccg gca gag 822 Pro Leu Thr Pro Ala Ile Tyr Thr Gly Ala Val Glu Glu Pro Ala Glu 170 175 180 gtc ccg gtc cca gag cag gga tgg agg aac aag ggc gcc atg atc atc 870 Val Pro Val Pro Glu Gln Gly Trp Arg Asn Lys Gly Ala Met Ile Ile 185 190 195 200 tac acc agt ggg acc acg ggg agg ccc aag ggc gtg ctg agc acg cac 918 Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Val Leu Ser Thr His 205 210 215 caa aac atc agg gct gtg gtg acc ggg ctg gtc cac aag tgg gca tgg 966 Gln Asn Ile Arg Ala Val Val Thr Gly Leu Val His Lys Trp Ala Trp 220 225 230 acc aaa gac gac gtg atc ctc cac gtg ctc ccg ctg cac cac gtc cat 1014 Thr Lys Asp Asp Val Ile Leu His Val Leu Pro Leu His His Val His 235 240 245 ggt gtg gtc aac gcg ctg ctc tgt cct ctc tgg gtg gga gcc acc tgt 1062 Gly Val Val Asn Ala Leu Leu Cys Pro Leu Trp Val Gly Ala Thr Cys 250 255 260 gtg atg atg cct gag ttc agc cct cag cag gtt tgg gaa gag ttc tta 1110 Val Met Met Pro Glu Phe Ser Pro Gln Gln Val Trp Glu Glu Phe Leu 265 270 275 280 agt tct gaa acg ccg cgg atc aat gtc ttt atg gca gtg cct aca ata 1158 Ser Ser Glu Thr Pro Arg Ile Asn Val Phe Met Ala Val Pro Thr Ile 285 290 295 tac acc aag ctg atg gag tac tac gac agg cat ttt acc cag ccg cac 1206 Tyr Thr Lys Leu Met Glu Tyr Tyr Asp Arg His Phe Thr Gln Pro His 300 305 310 gcc cag gat ttc ttg cgt gca gtt tgt gaa gaa aaa att agg ctg atg 1254 Ala Gln Asp Phe Leu Arg Ala Val Cys Glu Glu Lys Ile Arg Leu Met 315 320 325 gtc tca ggc tca gct gcc ctg ccc ctc cca gtg ctg gag aag tgg aag 1302 Val Ser Gly Ser Ala Ala Leu Pro Leu Pro Val Leu Glu Lys Trp Lys 330 335 340 aac atc acg ggc cac acc ctg ctg gag cgg tat ggc atg acc gag atc 1350 Asn Ile Thr Gly His Thr Leu Leu Glu Arg Tyr Gly Met Thr Glu Ile 345 350 355 360 ggc atg gct ctg tcc ggg ccc ctg acc act gcc gtg cgc ctg cca ggt 1398 Gly Met Ala Leu Ser Gly Pro Leu Thr Thr Ala Val Arg Leu Pro Gly 365 370 375 tcc gtg ggg acc cca ctg cct gga gta cag gtg cgc att gtc tca gaa 1446 Ser Val Gly Thr Pro Leu Pro Gly Val Gln Val Arg Ile Val Ser Glu 380 385 390 aac cca cag agg gaa gcc tgc tcc tac acc atc cac gca gag gga gac 1494 Asn Pro Gln Arg Glu Ala Cys Ser Tyr Thr Ile His Ala Glu Gly Asp 395 400 405 gag agg ggg acc aag gtg acc cca ggg ttt gaa gaa aag gag ggg gag 1542 Glu Arg Gly Thr Lys Val Thr Pro Gly Phe Glu Glu Lys Glu Gly Glu 410 415 420 ctg ctg gtg agg gga ccc tcc gtg ttt cga gaa tac tgg aat aaa cca 1590 Leu Leu Val Arg Gly Pro Ser Val Phe Arg Glu Tyr Trp Asn Lys Pro 425 430 435 440 gaa gaa act aag agt gca ttc acc ctg gat ggc tgg ttt aag aca ggg 1638 Glu Glu Thr Lys Ser Ala Phe Thr Leu Asp Gly Trp Phe Lys Thr Gly 445 450 455 gac acc gtg gtg ttt aag gat ggc cag tac tgg atc cga ggc cgg acc 1686 Asp Thr Val Val Phe Lys Asp Gly Gln Tyr Trp Ile Arg Gly Arg Thr 460 465 470 tca gtg gac atc atc aag act gga ggc tac aag gtc agc gcc ctg gag 1734 Ser Val Asp Ile Ile Lys Thr Gly Gly Tyr Lys Val Ser Ala Leu Glu 475 480 485 gtg gag tgg cac ctg ctg gcc cac ccc agc atc aca gat gtg gct gtg 1782 Val Glu Trp His Leu Leu Ala His Pro Ser Ile Thr Asp Val Ala Val 490 495 500 att gga gtt ccg gat atg aca tgg ggc cag cgg gtc act gct gtg gtg 1830 Ile Gly Val Pro Asp Met Thr Trp Gly Gln Arg Val Thr Ala Val Val 505 510 515 520 acc ctc cga gaa gga cac tca ctg tcc cac agg gag ctc aaa gag tgg 1878 Thr Leu Arg Glu Gly His Ser Leu Ser His Arg Glu Leu Lys Glu Trp 525 530 535 gcc aga aat gtc ctg gcc ccg tac gcg gtg ccc tcg gag ctg gtg ctg 1926 Ala Arg Asn Val Leu Ala Pro Tyr Ala Val Pro Ser Glu Leu Val Leu 540 545 550 gtg gag gag atc ccg cgg aac cag atg ggc aag att gac aag aag gcg 1974 Val Glu Glu Ile Pro Arg Asn Gln Met Gly Lys Ile Asp Lys Lys Ala 555 560 565 ctc atc agg cac ttc cac ccc tca tgacccggct gactgggact gcgggtctgg 2028 Leu Ile Arg His Phe His Pro Ser 570 575 tggggagcag cagacgtccc cttcacaccg agaaccacgg gggcccgtcc aagacctggc 2088 ctcccttaaa cctgaacccc ccaaatcagg tcacgtagaa tcaagaactg tttgggatga 2148 aatcaccatg tggggtcccc agcctcgggc cagttgttgc agctcaagga gaccgtccct 2208 ggtgtcacct ctgcctggtc accgccgacc tcatctgtgc agcgcggtgc agccagcccc 2268 tggccccacg tgctgaggca cctcccgccc cacagtgccc tgcagttgcc aggctctcca 2328 gggcaggtcc cagaggtttc ccacaaaaaa caaagactcc actggaggaa acaagcccct 2388 gtcccacgcc gtctgcacgt gcctgtgcct cacccagagc cagtgtctcc cagcccacat 2448 aggaggtctg ggcagccacc cagggggccc tcctgggagg agctgagggt tcacaagcct 2508 cccagaacca gccctgtccc atgggttccg tgcatttcct ggtgctgctc ttggaggaga 2568 gcagctccca ctgtggggac acctgccacc ctgcacacta ctgtgtgtcc atcagcatgt 2628 gtcacagaaa gtgcgtggac ggatggcccc ggagctgctc tgccctgacc ctgcctcacc 2688 ccccagcgca gggactttcc aggtcatctc cacaccagcc cctcagccgg tgaaccctct 2748 ctcccatcac cgtctccacc cagaccccca cctgccccat ggcccccatt tcatgtctgt 2808 ggctcaccag cttttcccca gacccagctc cggagcccac aggcgtggcc gatgcagaaa 2868 cctcaggaag gtgtgttgtg aatgttgggt gcacccacgt tgcatttact tagcggggcc 2928 aattcagatg cacaggggcc acatgcagaa tccagaagtt tctggacaat tttcagaaga 2988 ataggctgcc tcctccccac agcctggggg aagtaacagt catcgcccag cagtgtctgg 3048 cctgaactta cccagaacat tctgcccccg gaatgcacgt ctgaaagagt ggccagaaac 3108 gagtgtgccg ggcaggaggc cagccccatc tcaggctcac gtgcctctga caggagacca 3168 gccccatctc agactcacat gcctcgcgga cagttggacg tggcctgggg cccctgctca 3228 cttgagcatg tcgcccacca agcttgtctg aggccacaga gcagcgtccc agccctgttt 3288 tccaggactg gtgggtgccc cagtccacgg ccctgcccca cccgaactcc tgcctcacgg 3348 tgtggccttg tgcatcccca tggcctgacc ccgggaacag tcagaggaag gggtcccgcc 3408 ctcccgccag aggcctggac ccaagggaac ggcagtcaga gactacagtc cagacgtttg 3468 tgtctaggcc ttgctggtag ctaaggaaat gccttctgtt gggaaaaggt caaatttaac 3528 atagcaaaat ttttacttaa ttccact 3555 <210> 216 <211> 576 <212> PRT <213> Homo sapiens <400> 216 Met Leu Pro His Val Val Leu Thr Phe Arg Arg Leu Gly Cys Ala Leu 1 5 10 15 Ala Ser Cys Arg Leu Ala Pro Ala Arg His Arg Gly Ser Gly Leu Leu 20 25 30 His Thr Ala Pro Val Ala Arg Ser Asp Arg Ser Ala Pro Val Phe Thr 35 40 45 Arg Ala Leu Ala Phe Gly Asp Arg Ile Ala Leu Val Asp Gln His Gly 50 55 60 Arg His Thr Tyr Arg Glu Leu Tyr Ser Arg Ser Leu Arg Leu Ser Gln 65 70 75 80 Glu Ile Cys Arg Leu Cys Gly Cys Val Gly Gly Asp Leu Arg Glu Glu 85 90 95 Arg Val Ser Phe Leu Cys Ala Asn Asp Ala Ser Tyr Val Val Ala Gln 100 105 110 Trp Ala Ser Trp Met Ser Gly Gly Val Ala Val Pro Leu Tyr Arg Lys 115 120 125 His Pro Ala Ala Gln Leu Glu Tyr Val Ile Cys Asp Ser Gln Ser Ser 130 135 140 Val Val Leu Ala Ser Gln Glu Tyr Leu Glu Leu Leu Ser Pro Val Val 145 150 155 160 Arg Lys Leu Gly Val Pro Leu Leu Pro Leu Thr Pro Ala Ile Tyr Thr 165 170 175 Gly Ala Val Glu Glu Pro Ala Glu Val Pro Val Pro Glu Gln Gly Trp 180 185 190 Arg Asn Lys Gly Ala Met Ile Ile Tyr Thr Ser Gly Thr Thr Gly Arg 195 200 205 Pro Lys Gly Val Leu Ser Thr His Gln Asn Ile Arg Ala Val Val Thr 210 215 220 Gly Leu Val His Lys Trp Ala Trp Thr Lys Asp Asp Val Ile Leu His 225 230 235 240 Val Leu Pro Leu His His Val His Gly Val Val Asn Ala Leu Leu Cys 245 250 255 Pro Leu Trp Val Gly Ala Thr Cys Val Met Met Pro Glu Phe Ser Pro 260 265 270 Gln Gln Val Trp Glu Glu Phe Leu Ser Ser Glu Thr Pro Arg Ile Asn 275 280 285 Val Phe Met Ala Val Pro Thr Ile Tyr Thr Lys Leu Met Glu Tyr Tyr 290 295 300 Asp Arg His Phe Thr Gln Pro His Ala Gln Asp Phe Leu Arg Ala Val 305 310 315 320 Cys Glu Glu Lys Ile Arg Leu Met Val Ser Gly Ser Ala Ala Leu Pro 325 330 335 Leu Pro Val Leu Glu Lys Trp Lys Asn Ile Thr Gly His Thr Leu Leu 340 345 350 Glu Arg Tyr Gly Met Thr Glu Ile Gly Met Ala Leu Ser Gly Pro Leu 355 360 365 Thr Thr Ala Val Arg Leu Pro Gly Ser Val Gly Thr Pro Leu Pro Gly 370 375 380 Val Gln Val Arg Ile Val Ser Glu Asn Pro Gln Arg Glu Ala Cys Ser 385 390 395 400 Tyr Thr Ile His Ala Glu Gly Asp Glu Arg Gly Thr Lys Val Thr Pro 405 410 415 Gly Phe Glu Glu Lys Glu Gly Glu Leu Leu Val Arg Gly Pro Ser Val 420 425 430 Phe Arg Glu Tyr Trp Asn Lys Pro Glu Glu Thr Lys Ser Ala Phe Thr 435 440 445 Leu Asp Gly Trp Phe Lys Thr Gly Asp Thr Val Val Phe Lys Asp Gly 450 455 460 Gln Tyr Trp Ile Arg Gly Arg Thr Ser Val Asp Ile Ile Lys Thr Gly 465 470 475 480 Gly Tyr Lys Val Ser Ala Leu Glu Val Glu Trp His Leu Leu Ala His 485 490 495 Pro Ser Ile Thr Asp Val Ala Val Ile Gly Val Pro Asp Met Thr Trp 500 505 510 Gly Gln Arg Val Thr Ala Val Val Thr Leu Arg Glu Gly His Ser Leu 515 520 525 Ser His Arg Glu Leu Lys Glu Trp Ala Arg Asn Val Leu Ala Pro Tyr 530 535 540 Ala Val Pro Ser Glu Leu Val Leu Val Glu Glu Ile Pro Arg Asn Gln 545 550 555 560 Met Gly Lys Ile Asp Lys Lys Ala Leu Ile Arg His Phe His Pro Ser 565 570 575 <210> 217 <211> 2083 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (134)..(1162) <400> 217 atttcctttc tccacatcca ggtcaggtgg cgtttgctgt ggcggctagg cccgcgtgcg 60 ctggagacct ccgcgctggc ccccgcgagc ctcctgccct ggcccggcgc tgcggctctg 120 ccgcggcggc agc atg ggt ggc ccc cgg ggc gcg ggc tgg gtg gcg gcg 169 Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala 1 5 10 ggc ctg ctg ctc ggc gcg ggc gcc tgc tac tgc att tac agg ctg acc 217 Gly Leu Leu Leu Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr 15 20 25 cgg ggt cgg cgg cgg ggc gac cgc gag ctc ggg ata cgc tct tcg aag 265 Arg Gly Arg Arg Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys 30 35 40 tcc gca ggt gcc ctg gaa gaa ggg acg tca gag ggt cag ttg tgc ggg 313 Ser Ala Gly Ala Leu Glu Glu Gly Thr Ser Glu Gly Gln Leu Cys Gly 45 50 55 60 cgc tcg gcc cgg cct cag acg gga ggt acc tgg gag tca cag tgg tcc 361 Arg Ser Ala Arg Pro Gln Thr Gly Gly Thr Trp Glu Ser Gln Trp Ser 65 70 75 aag acc tcg cag cct gaa gac ttg act gat ggt tca tat gat gat gtt 409 Lys Thr Ser Gln Pro Glu Asp Leu Thr Asp Gly Ser Tyr Asp Asp Val 80 85 90 cta aat gct gaa caa ctt cag aaa ctc ctt tac ctg ctg gag tca acg 457 Leu Asn Ala Glu Gln Leu Gln Lys Leu Leu Tyr Leu Leu Glu Ser Thr 95 100 105 gag gat cct gta att att gaa aga gct ttg att act ttg ggt aac aat 505 Glu Asp Pro Val Ile Ile Glu Arg Ala Leu Ile Thr Leu Gly Asn Asn 110 115 120 gca gcc ttt tca gtt aac caa gct att att cgt gaa ttg ggt ggt att 553 Ala Ala Phe Ser Val Asn Gln Ala Ile Ile Arg Glu Leu Gly Gly Ile 125 130 135 140 cca att gtt gca aac aaa atc aac cat tcc aac cag agt att aaa gag 601 Pro Ile Val Ala Asn Lys Ile Asn His Ser Asn Gln Ser Ile Lys Glu 145 150 155 aaa gct tta aat gca cta aat aac ctg agt gtg aat gtt gaa aat caa 649 Lys Ala Leu Asn Ala Leu Asn Asn Leu Ser Val Asn Val Glu Asn Gln 160 165 170 atc aag ata aag ata tac atc agt caa gta tgt gag gat gtc ttc tct 697 Ile Lys Ile Lys Ile Tyr Ile Ser Gln Val Cys Glu Asp Val Phe Ser 175 180 185 ggt cct ctg aac tct gct gtg cag ctg gct gga ctg aca ttg ttg aca 745 Gly Pro Leu Asn Ser Ala Val Gln Leu Ala Gly Leu Thr Leu Leu Thr 190 195 200 aac atg act gtt acc aat gac cac cag cac atg ctt cac agt tac att 793 Asn Met Thr Val Thr Asn Asp His Gln His Met Leu His Ser Tyr Ile 205 210 215 220 aca gac ctg ttc cag gtg tta ctt act gga aat gga aac acg aag gtg 841 Thr Asp Leu Phe Gln Val Leu Leu Thr Gly Asn Gly Asn Thr Lys Val 225 230 235 caa gtt ttg aaa ctg ctt ttg aat ttg tct gaa aat cca gcc atg aca 889 Gln Val Leu Lys Leu Leu Leu Asn Leu Ser Glu Asn Pro Ala Met Thr 240 245 250 gaa gga ctt ctc cgt gcc caa gtg gat tca tca ttc ctt tcc ctt tat 937 Glu Gly Leu Leu Arg Ala Gln Val Asp Ser Ser Phe Leu Ser Leu Tyr 255 260 265 gac agc cac gta gca aag gag att ctt ctt cga gta ctt acg cta ttt 985 Asp Ser His Val Ala Lys Glu Ile Leu Leu Arg Val Leu Thr Leu Phe 270 275 280 cag aat ata aag aac tgc ctc aaa ata gaa ggc cat tta gct gtg cag 1033 Gln Asn Ile Lys Asn Cys Leu Lys Ile Glu Gly His Leu Ala Val Gln 285 290 295 300 cct act ttc act gaa ggt tca ttg ttt ttc ctg tta cat gga gaa gaa 1081 Pro Thr Phe Thr Glu Gly Ser Leu Phe Phe Leu Leu His Gly Glu Glu 305 310 315 tgt gcc cag aaa ata aga gct tta gtt gat cac cat gat gca gag gtg 1129 Cys Ala Gln Lys Ile Arg Ala Leu Val Asp His His Asp Ala Glu Val 320 325 330 aag gaa aag gtt gta aca ata ata ccc aaa atc tgattggtca tatttttcca 1182 Lys Glu Lys Val Val Thr Ile Ile Pro Lys Ile 335 340 aagagtaatg cagtctggat ataaatgtat tttctgtctt ccttataagg ggattctccc 1242 agctgctaaa tttaaacagt aaatatcaca ttttgtcatt aacacagcta taacttgccg 1302 tggttctcag atttattttg gactattttg atgccaagtg aatataagag cttgtactga 1362 aaccatttat ttctttctat tttgctattt gcaaatgctt gttatcttcc ctacatgaag 1422 tggcagtaac ctttttcaca tttaagctac ccttctacct tttgaagtga tttgcagtta 1482 ctcatctgag acagcatcag tatttgacta aatcattgtt tcacaactga atagtcttgt 1542 tcttttagta gcaatgaaat cctaagctct tgaggccatt cacctgccaa cctgaccata 1602 ctgctttcaa aagtcttttc tcatcagtag aatctatttt ggtcacttct agtcaatgaa 1662 aaatgtaaac ttttaggaga gaatgtttcc taggactcac ccactccatt caatgttaca 1722 tataaaatag tgtgatcaat cacaatgtcc atctttagac agttggttaa ataaattatc 1782 tggtctttga aaagaccgtg ctgggcgcgg tggctcttgc ctgtaatccc agcactttgg 1842 gaggctgagg cgggcagatc acctgagatc gggagtttga gaccaagcct gaccaatatg 1902 gagaaaccct gtctctacta agaatacaaa attagctggg catggtggtg catgcctgta 1962 atcccagcta cttgggaggc cgaggcagga gaattgcttg aacccgggag gcagaggttg 2022 cagtgaggtg agatagcgcc attgcactcc agcctgggca acaagagcaa aactctgtct 2082 c 2083 <210> 218 <211> 343 <212> PRT <213> Homo sapiens <400> 218 Met Gly Gly Pro Arg Gly Ala Gly Trp Val Ala Ala Gly Leu Leu Leu 1 5 10 15 Gly Ala Gly Ala Cys Tyr Cys Ile Tyr Arg Leu Thr Arg Gly Arg Arg 20 25 30 Arg Gly Asp Arg Glu Leu Gly Ile Arg Ser Ser Lys Ser Ala Gly Ala 35 40 45 Leu Glu Glu Gly Thr Ser Glu Gly Gln Leu Cys Gly Arg Ser Ala Arg 50 55 60 Pro Gln Thr Gly Gly Thr Trp Glu Ser Gln Trp Ser Lys Thr Ser Gln 65 70 75 80 Pro Glu Asp Leu Thr Asp Gly Ser Tyr Asp Asp Val Leu Asn Ala Glu 85 90 95 Gln Leu Gln Lys Leu Leu Tyr Leu Leu Glu Ser Thr Glu Asp Pro Val 100 105 110 Ile Ile Glu Arg Ala Leu Ile Thr Leu Gly Asn Asn Ala Ala Phe Ser 115 120 125 Val Asn Gln Ala Ile Ile Arg Glu Leu Gly Gly Ile Pro Ile Val Ala 130 135 140 Asn Lys Ile Asn His Ser Asn Gln Ser Ile Lys Glu Lys Ala Leu Asn 145 150 155 160 Ala Leu Asn Asn Leu Ser Val Asn Val Glu Asn Gln Ile Lys Ile Lys 165 170 175 Ile Tyr Ile Ser Gln Val Cys Glu Asp Val Phe Ser Gly Pro Leu Asn 180 185 190 Ser Ala Val Gln Leu Ala Gly Leu Thr Leu Leu Thr Asn Met Thr Val 195 200 205 Thr Asn Asp His Gln His Met Leu His Ser Tyr Ile Thr Asp Leu Phe 210 215 220 Gln Val Leu Leu Thr Gly Asn Gly Asn Thr Lys Val Gln Val Leu Lys 225 230 235 240 Leu Leu Leu Asn Leu Ser Glu Asn Pro Ala Met Thr Glu Gly Leu Leu 245 250 255 Arg Ala Gln Val Asp Ser Ser Phe Leu Ser Leu Tyr Asp Ser His Val 260 265 270 Ala Lys Glu Ile Leu Leu Arg Val Leu Thr Leu Phe Gln Asn Ile Lys 275 280 285 Asn Cys Leu Lys Ile Glu Gly His Leu Ala Val Gln Pro Thr Phe Thr 290 295 300 Glu Gly Ser Leu Phe Phe Leu Leu His Gly Glu Glu Cys Ala Gln Lys 305 310 315 320 Ile Arg Ala Leu Val Asp His His Asp Ala Glu Val Lys Glu Lys Val 325 330 335 Val Thr Ile Ile Pro Lys Ile 340 <210> 219 <211> 2586 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (54)..(902) <400> 219 attcggcggg agcacccagt cctgtacgcc aaggaactgg tcctgggggc acc atg 56 Met 1 gtt tcg gcg gca gcc ccc agc ctc ctc atc ctt ctg ttg ctg ctc ctg 104 Val Ser Ala Ala Ala Pro Ser Leu Leu Ile Leu Leu Leu Leu Leu Leu 5 10 15 ggg tct gtg cct gct acc gac gcc cgc tct gtg ccc ctg aag gcc acg 152 Gly Ser Val Pro Ala Thr Asp Ala Arg Ser Val Pro Leu Lys Ala Thr 20 25 30 ttc ctg gag gat gtg gcg ggt agt ggg gaa gcc gag ggc tcg tcg gcc 200 Phe Leu Glu Asp Val Ala Gly Ser Gly Glu Ala Glu Gly Ser Ser Ala 35 40 45 tcc tcc ccg agc ctc ccg cca ccc tgg acc ccg gcc ctc agc ccc aca 248 Ser Ser Pro Ser Leu Pro Pro Pro Trp Thr Pro Ala Leu Ser Pro Thr 50 55 60 65 tcg atg ggg ccc cag ccc aca acc ctg ggg ggc cca tca ccc ccc acc 296 Ser Met Gly Pro Gln Pro Thr Thr Leu Gly Gly Pro Ser Pro Pro Thr 70 75 80 aac ttc ctg gat ggg ata gtg gac ttc ttc cgc cag tac gtg atg ctg 344 Asn Phe Leu Asp Gly Ile Val Asp Phe Phe Arg Gln Tyr Val Met Leu 85 90 95 att gct gtg gtg ggc tcc ctg gcc ttt ctg ctg atg ttc atc gtc tgt 392 Ile Ala Val Val Gly Ser Leu Ala Phe Leu Leu Met Phe Ile Val Cys 100 105 110 gcc gcg gtc atc acc cgg cag aag cag aag gcc tcg gcc tat tac cca 440 Ala Ala Val Ile Thr Arg Gln Lys Gln Lys Ala Ser Ala Tyr Tyr Pro 115 120 125 tcg tcc ttc ccc aag aag aag tac gtg gac cag agt gac cgg gcc ggg 488 Ser Ser Phe Pro Lys Lys Lys Tyr Val Asp Gln Ser Asp Arg Ala Gly 130 135 140 145 ggc ccc cgg gcc ttc agt gag gtc ccc gac aga gcc ccc gac agc agg 536 Gly Pro Arg Ala Phe Ser Glu Val Pro Asp Arg Ala Pro Asp Ser Arg 150 155 160 ccc gag gaa gcc ctg gat tcc tcc cgg cag ctc cag gcc gac atc ttg 584 Pro Glu Glu Ala Leu Asp Ser Ser Arg Gln Leu Gln Ala Asp Ile Leu 165 170 175 gcc gcc acc cag aac ctc aag tcc ccc acc agg gct gca ctg ggc ggt 632 Ala Ala Thr Gln Asn Leu Lys Ser Pro Thr Arg Ala Ala Leu Gly Gly 180 185 190 ggg gac gga gcc agg atg gtg gag ggc agg ggc gca gag gaa gag gag 680 Gly Asp Gly Ala Arg Met Val Glu Gly Arg Gly Ala Glu Glu Glu Glu 195 200 205 aag ggc agc cag gag ggg gac cag gaa gtc cag gga cat ggg gtc cca 728 Lys Gly Ser Gln Glu Gly Asp Gln Glu Val Gln Gly His Gly Val Pro 210 215 220 225 gtg gag aca cca gag gcg cag gag gag ccg tgc tca ggg gtc ctt gag 776 Val Glu Thr Pro Glu Ala Gln Glu Glu Pro Cys Ser Gly Val Leu Glu 230 235 240 ggg gct gtg gtg gcc ggt gag ggc caa ggg gag ctg gaa ggg tct ctc 824 Gly Ala Val Val Ala Gly Glu Gly Gln Gly Glu Leu Glu Gly Ser Leu 245 250 255 ttg tta gcc cag ggt gcc cag gga cca gtg ggt ccc ccc gaa agc ccc 872 Leu Leu Ala Gln Gly Ala Gln Gly Pro Val Gly Pro Pro Glu Ser Pro 260 265 270 tgt gct tgc agc agt gtc cac ccc agt gtc taacagtcct cccgggctgc 922 Cys Ala Cys Ser Ser Val His Pro Ser Val 275 280 cagccctgac tgtcgggccc ccaagtggtc acctccccgt gtgtgaaaag gccttcagcc 982 ctgactgctt cctgacactc cctccttggc ctccctgtgg tgccaatccc agcatgtgct 1042 gattctacag caggcagaaa tgctggtccc cggtgccccg gaggaatctt accaagtgcc 1102 atcatccttc acctcagcag ccccaaaggg ctacatccta cagcacagct cccctgacaa 1162 agtgagggag ggcacgtgtc cctgtgacag ccaggataaa acatccctca aggctgggtg 1222 tggaggctcg cgcctgtaat ctcagcattt tgggaggcca agtgcggaca tcacttgaga 1282 ccaggagttc caaaccagcc ctggcaacat tgtgagaccc atctctataa aaacaaaaaa 1342 cagtccacta aatcagccac attaattggg aatcatatgt cacaggtcat ttgtggggca 1402 aacatcactg cttttccatc aagggagcaa agaataagtg ggagttttgg aagagtttgg 1462 atgagagacg ccaaggtgcc cagcgttcgt aaggcaacat gcagcctggc gtgaagcagt 1522 attttgaaac tgcaaatggt tcccttcttg tgtcctttca atgctgaata ttttagtgtc 1582 attctgcctg tgctcagagc tccagcagca gaagtgtgtg tggttaatta ggacacttct 1642 gtgagaggac ccctgcacac attacgacag gtccctaaat gagcattccc caaactaggt 1702 tccccgaggc actctacgga aacaagattt ttttttttga gacggagtct cggtctgtca 1762 cccaggctgg agtgcagtgg tgcaatcttg gtgcaatctt ggctcagtgc aatccgcctc 1822 ccaggttcaa gcgattctcc cgcctcagta gctgggatta caggtgccca ccactgcgcc 1882 cagctaaatt ttgtattttt agtagagatg gggcttcacc atgttggcca ggctggtctg 1942 gaactcctga ccttcaggtg atccacctgc ctctgcctcc caaggtgctg ggattacagg 2002 cgtgagccac cgtgcccggc ccaaactact ttttaaaaca gctacagggt aaaatcctgc 2062 agcacccact ctggaaaata ctgctcttaa ttttcctgaa ggtggccccc tgtttctagt 2122 tggtccagga ttagggatgt ggggtatagg gcatttaaat cctctcaagc gctctccaag 2182 cacccccggc ctgggggtga gtttctcatc ccgctactgc tgctgggatc aggttgaatg 2242 aatggaactc ttcctgtctg gcctccaaag cagcctagaa gctgaggggc tgtgtttgag 2302 gggacctcca ccctggggaa gtccgagggg ctggggaagg gtttctgacg cccagcctgg 2362 agcagggggg ccctggccac cccctgttgc tcacacattg tctggcagcc tgtgtccaca 2422 atattcgtca gtcctcgaca gggagcctgg gctccgtcct gctttaggga ggctctggca 2482 ggaggtcctc tcccccatcc ctccatctgg ggctccccca acctctgcac agctctccag 2542 gtgctgagat ataatgcacc agcacaataa acctttattc cggc 2586 <210> 220 <211> 283 <212> PRT <213> Homo sapiens <400> 220 Met Val Ser Ala Ala Ala Pro Ser Leu Leu Ile Leu Leu Leu Leu Leu 1 5 10 15 Leu Gly Ser Val Pro Ala Thr Asp Ala Arg Ser Val Pro Leu Lys Ala 20 25 30 Thr Phe Leu Glu Asp Val Ala Gly Ser Gly Glu Ala Glu Gly Ser Ser 35 40 45 Ala Ser Ser Pro Ser Leu Pro Pro Pro Trp Thr Pro Ala Leu Ser Pro 50 55 60 Thr Ser Met Gly Pro Gln Pro Thr Thr Leu Gly Gly Pro Ser Pro Pro 65 70 75 80 Thr Asn Phe Leu Asp Gly Ile Val Asp Phe Phe Arg Gln Tyr Val Met 85 90 95 Leu Ile Ala Val Val Gly Ser Leu Ala Phe Leu Leu Met Phe Ile Val 100 105 110 Cys Ala Ala Val Ile Thr Arg Gln Lys Gln Lys Ala Ser Ala Tyr Tyr 115 120 125 Pro Ser Ser Phe Pro Lys Lys Lys Tyr Val Asp Gln Ser Asp Arg Ala 130 135 140 Gly Gly Pro Arg Ala Phe Ser Glu Val Pro Asp Arg Ala Pro Asp Ser 145 150 155 160 Arg Pro Glu Glu Ala Leu Asp Ser Ser Arg Gln Leu Gln Ala Asp Ile 165 170 175 Leu Ala Ala Thr Gln Asn Leu Lys Ser Pro Thr Arg Ala Ala Leu Gly 180 185 190 Gly Gly Asp Gly Ala Arg Met Val Glu Gly Arg Gly Ala Glu Glu Glu 195 200 205 Glu Lys Gly Ser Gln Glu Gly Asp Gln Glu Val Gln Gly His Gly Val 210 215 220 Pro Val Glu Thr Pro Glu Ala Gln Glu Glu Pro Cys Ser Gly Val Leu 225 230 235 240 Glu Gly Ala Val Val Ala Gly Glu Gly Gln Gly Glu Leu Glu Gly Ser 245 250 255 Leu Leu Leu Ala Gln Gly Ala Gln Gly Pro Val Gly Pro Pro Glu Ser 260 265 270 Pro Cys Ala Cys Ser Ser Val His Pro Ser Val 275 280 <210> 221 <211> 1548 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (20)..(1348) <400> 221 tctgaggcag gtgcccgac atg gcg agt gta gtg ctg ccg agc gga tcc cag 52 Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln 1 5 10 tgt gcg gcg gca gcg gcg gcg gcg gcg cct ccc ggg ctc cgg ctc cgg 100 Cys Ala Ala Ala Ala Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg 15 20 25 ctt ctg ctg ttg ctc ttc tcc gcc gcg gca ctg atc ccc aca ggt gat 148 Leu Leu Leu Leu Leu Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp 30 35 40 ggg cag aat ctg ttt acg aaa gac gtg aca gtg atc gag gga gag gtt 196 Gly Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val 45 50 55 gcg acc atc agt tgc caa gtc aat aag agt gac gac tct gtg att cag 244 Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln 60 65 70 75 cta ctg aat ccc aac agg cag acc att tat ttc agg gac ttc agg cct 292 Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro 80 85 90 ttg aag gac agc agg ttt cag ttg ctg aat ttt tct agc agt gaa ctc 340 Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu 95 100 105 aaa gta tca ttg aca aac gtc tca att tct gat gaa gga aga tac ttt 388 Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe 110 115 120 tgc cag ctc tat acc gat ccc cca cag gaa agt tac acc acc atc aca 436 Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr 125 130 135 gtc ctg gtc cca cca cgt aat ctg atg atc gat atc cag aaa gac act 484 Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr 140 145 150 155 gcg gtg gaa ggt gag gag att gaa gtc aac tgc act gct atg gcc agc 532 Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser 160 165 170 aag cca gcc acg act atc agg tgg ttc aaa ggg aac aca gag cta aaa 580 Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys 175 180 185 ggc aaa tcg gag gtg gaa gag tgg tca gac atg tac act gtg acc agt 628 Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser 190 195 200 cag ctg atg ctg aag gtg cac aag gag gac gat ggg gtc cca gtg atc 676 Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro Val Ile 205 210 215 tgc cag gtg gag cac cct gcg gtc act gga aac ctg cag acc cag cgg 724 Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg 220 225 230 235 tat cta gaa gta cag tat aag cct caa gtg cac att cag atg act tat 772 Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr 240 245 250 cct cta caa ggc tta acc cgg gaa ggg gac gcg ctt gag tta aca tgt 820 Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys 255 260 265 gaa gcc atc ggg aag ccc cag cct gtg atg gta act tgg gtg aga gtc 868 Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val Arg Val 270 275 280 gat gat gaa atg cct caa cac gcc gta ctg tct ggg ccc aac ctg ttc 916 Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe 285 290 295 atc aat aac cta aac aaa aca gat aat ggt aca tac cgc tgt gaa gct 964 Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala 300 305 310 315 tca aac ata gtg ggg aaa gct cac tcg gat tat atg ctg tat gta tac 1012 Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr 320 325 330 gac aca acg gcg acg aca gaa cca gca gtt cac ggc ctt act cag ttg 1060 Asp Thr Thr Ala Thr Thr Glu Pro Ala Val His Gly Leu Thr Gln Leu 335 340 345 ccc aat tcc gca gaa gaa ctg gac agt gag gac ctc tca gat tcc cga 1108 Pro Asn Ser Ala Glu Glu Leu Asp Ser Glu Asp Leu Ser Asp Ser Arg 350 355 360 gca ggt gaa gaa ggc tcg atc agg gca gtg gat cat gcc gtg atc ggt 1156 Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp His Ala Val Ile Gly 365 370 375 ggc gtc gtg gcg gtg gtg gtg ttc gcc atg ctg tgc ttg ctc atc att 1204 Gly Val Val Ala Val Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile 380 385 390 395 ctg ggg cgc tat ttt gcc aga cat aaa ggt aca tac ttc act cat gaa 1252 Leu Gly Arg Tyr Phe Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu 400 405 410 gcc aaa gga gcc gat gac gca gca gac gca gac aca gct ata atc aat 1300 Ala Lys Gly Ala Asp Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn 415 420 425 gca gaa gga gga cag aac aac tcc gaa gaa aag aaa gag tac ttc atc 1348 Ala Glu Gly Gly Gln Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 430 435 440 tagatcagcc tttttgtttc aatgaggtgt ccaactggcc ctatttagat gataaagaga 1408 cagtgatatt ggaacttgcg agaaattcgt gtgttttttt atgaatgggt ggaaaggtgt 1468 gagactggga aggcttggga tttgctgtgt aaaaaaaaaa aaaatgttct ttggaaagta 1528 cactctgctg tttgacacct 1548 <210> 222 <211> 443 <212> PRT <213> Homo sapiens <400> 222 Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 1 5 10 15 Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 20 25 30 Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 35 40 45 Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 50 55 60 Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 65 70 75 80 Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 85 90 95 Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 100 105 110 Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 115 120 125 Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 130 135 140 Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 145 150 155 160 Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 165 170 175 Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 180 185 190 Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 195 200 205 Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 210 215 220 Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 225 230 235 240 Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 245 250 255 Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 260 265 270 Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 275 280 285 Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 290 295 300 Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 305 310 315 320 Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Thr Thr Ala Thr 325 330 335 Thr Glu Pro Ala Val His Gly Leu Thr Gln Leu Pro Asn Ser Ala Glu 340 345 350 Glu Leu Asp Ser Glu Asp Leu Ser Asp Ser Arg Ala Gly Glu Glu Gly 355 360 365 Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val 370 375 380 Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe 385 390 395 400 Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp 405 410 415 Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln 420 425 430 Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 435 440 <210> 223 <211> 1457 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (14)..(982) <400> 223 agaggggaac aag atg gcg gcg ccg aag ggg agc ctc tgg gtg agg acc 49 Met Ala Ala Pro Lys Gly Ser Leu Trp Val Arg Thr 1 5 10 caa ctg ggg ctc ccg ccg ctg ctg ctg ctg acc atg gcc ttg gcc gga 97 Gln Leu Gly Leu Pro Pro Leu Leu Leu Leu Thr Met Ala Leu Ala Gly 15 20 25 ggt tcg ggg acc gct tcg gct gaa gca ttt gac tcg gtc ttg ggt gat 145 Gly Ser Gly Thr Ala Ser Ala Glu Ala Phe Asp Ser Val Leu Gly Asp 30 35 40 acg gcg tct tgc cac cgg gcc tgt cag ttg acc tac ccc ttg cac acc 193 Thr Ala Ser Cys His Arg Ala Cys Gln Leu Thr Tyr Pro Leu His Thr 45 50 55 60 tac cct aag gaa gag gag ttg tac gca tgt cag aga ggt tgc agg ctg 241 Tyr Pro Lys Glu Glu Glu Leu Tyr Ala Cys Gln Arg Gly Cys Arg Leu 65 70 75 ttt tca att tgt cag ttt gtg gat gat gga att gac tta aat cga act 289 Phe Ser Ile Cys Gln Phe Val Asp Asp Gly Ile Asp Leu Asn Arg Thr 80 85 90 aaa ttg gaa tgt gaa tct gca tgt aca gaa gca tat tcc caa tct gat 337 Lys Leu Glu Cys Glu Ser Ala Cys Thr Glu Ala Tyr Ser Gln Ser Asp 95 100 105 gag caa tat gct tgc cat ctt ggt tgc cag aat cag ctg cca ttc gct 385 Glu Gln Tyr Ala Cys His Leu Gly Cys Gln Asn Gln Leu Pro Phe Ala 110 115 120 gaa ctg aga caa gaa caa ctt atg tcc ctg atg cca aaa atg cac cta 433 Glu Leu Arg Gln Glu Gln Leu Met Ser Leu Met Pro Lys Met His Leu 125 130 135 140 ctc ttt cct cta act ctg gtg agg tca ttc tgg agt gac atg atg gac 481 Leu Phe Pro Leu Thr Leu Val Arg Ser Phe Trp Ser Asp Met Met Asp 145 150 155 tcc gca cag agc ttc ata acc tct tca tgg act ttt tat ctt caa gcc 529 Ser Ala Gln Ser Phe Ile Thr Ser Ser Trp Thr Phe Tyr Leu Gln Ala 160 165 170 gat gac gga aaa ata gtt ata ttc cag tct aag cca gaa atc cag tac 577 Asp Asp Gly Lys Ile Val Ile Phe Gln Ser Lys Pro Glu Ile Gln Tyr 175 180 185 gca cca cat ttg gag cag gag cct aca aat ttg aga gaa tca tct cta 625 Ala Pro His Leu Glu Gln Glu Pro Thr Asn Leu Arg Glu Ser Ser Leu 190 195 200 agc aaa atg tcc tat ctg caa atg aga aat tca caa gcg cac agg aat 673 Ser Lys Met Ser Tyr Leu Gln Met Arg Asn Ser Gln Ala His Arg Asn 205 210 215 220 ttt ctt gaa gat gga gaa agt gat ggc ttt tta aga tgc ctc tct ctt 721 Phe Leu Glu Asp Gly Glu Ser Asp Gly Phe Leu Arg Cys Leu Ser Leu 225 230 235 aac tct ggg tgg att tta act aca act ctt gtc ctc tcg gtg atg gta 769 Asn Ser Gly Trp Ile Leu Thr Thr Thr Leu Val Leu Ser Val Met Val 240 245 250 ttg ctt tgg att tgt tgt gca act gtt gct aca gct gtg gag cag tat 817 Leu Leu Trp Ile Cys Cys Ala Thr Val Ala Thr Ala Val Glu Gln Tyr 255 260 265 gtt ccc tct gag aag ctg agt atc tat ggt gac ttg gag ttt atg aat 865 Val Pro Ser Glu Lys Leu Ser Ile Tyr Gly Asp Leu Glu Phe Met Asn 270 275 280 gaa caa aag cta aac aga tat cca gct tct tct ctt gtg gtt gtt aga 913 Glu Gln Lys Leu Asn Arg Tyr Pro Ala Ser Ser Leu Val Val Val Arg 285 290 295 300 tct aaa act gaa gat cat gaa gaa gca ggg cct cta cct aca aaa gtg 961 Ser Lys Thr Glu Asp His Glu Glu Ala Gly Pro Leu Pro Thr Lys Val 305 310 315 aat ctt gct cat tct gaa att taagcatttt tcttttaaaa gacaagtgta 1012 Asn Leu Ala His Ser Glu Ile 320 atagacatct aaaattccac tcctcataga gcttttaaaa tggtttcatt ggatataggc 1072 cttaagaaat cactataaaa tgcaaataaa gttactcaaa tctgtgaaga ctgtatttgc 1132 tataacttta ttggtattgt ttttgtagta atttaagagg tggatgtttg ggattgtatt 1192 attattttac taatatctgt agctattttg ttttttgctt tggttattgt ttttttccct 1252 tttcttagct atgagctgat cattgctcct tctcacctcc tgccatgata ctgtcagtta 1312 ccttagttaa caagctgaat atttagtaga aatgatgctt ctgctcagga atggcccaca 1372 aatctgtaat ttgaaattta gcaggaaatg acctttaatg acactacatt ttcaggaact 1432 gaaatcatta aaattttatt tgaat 1457 <210> 224 <211> 323 <212> PRT <213> Homo sapiens <400> 224 Met Ala Ala Pro Lys Gly Ser Leu Trp Val Arg Thr Gln Leu Gly Leu 1 5 10 15 Pro Pro Leu Leu Leu Leu Thr Met Ala Leu Ala Gly Gly Ser Gly Thr 20 25 30 Ala Ser Ala Glu Ala Phe Asp Ser Val Leu Gly Asp Thr Ala Ser Cys 35 40 45 His Arg Ala Cys Gln Leu Thr Tyr Pro Leu His Thr Tyr Pro Lys Glu 50 55 60 Glu Glu Leu Tyr Ala Cys Gln Arg Gly Cys Arg Leu Phe Ser Ile Cys 65 70 75 80 Gln Phe Val Asp Asp Gly Ile Asp Leu Asn Arg Thr Lys Leu Glu Cys 85 90 95 Glu Ser Ala Cys Thr Glu Ala Tyr Ser Gln Ser Asp Glu Gln Tyr Ala 100 105 110 Cys His Leu Gly Cys Gln Asn Gln Leu Pro Phe Ala Glu Leu Arg Gln 115 120 125 Glu Gln Leu Met Ser Leu Met Pro Lys Met His Leu Leu Phe Pro Leu 130 135 140 Thr Leu Val Arg Ser Phe Trp Ser Asp Met Met Asp Ser Ala Gln Ser 145 150 155 160 Phe Ile Thr Ser Ser Trp Thr Phe Tyr Leu Gln Ala Asp Asp Gly Lys 165 170 175 Ile Val Ile Phe Gln Ser Lys Pro Glu Ile Gln Tyr Ala Pro His Leu 180 185 190 Glu Gln Glu Pro Thr Asn Leu Arg Glu Ser Ser Leu Ser Lys Met Ser 195 200 205 Tyr Leu Gln Met Arg Asn Ser Gln Ala His Arg Asn Phe Leu Glu Asp 210 215 220 Gly Glu Ser Asp Gly Phe Leu Arg Cys Leu Ser Leu Asn Ser Gly Trp 225 230 235 240 Ile Leu Thr Thr Thr Leu Val Leu Ser Val Met Val Leu Leu Trp Ile 245 250 255 Cys Cys Ala Thr Val Ala Thr Ala Val Glu Gln Tyr Val Pro Ser Glu 260 265 270 Lys Leu Ser Ile Tyr Gly Asp Leu Glu Phe Met Asn Glu Gln Lys Leu 275 280 285 Asn Arg Tyr Pro Ala Ser Ser Leu Val Val Val Arg Ser Lys Thr Glu 290 295 300 Asp His Glu Glu Ala Gly Pro Leu Pro Thr Lys Val Asn Leu Ala His 305 310 315 320 Ser Glu Ile <210> 225 <211> 1484 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (225)..(650) <400> 225 atcaagtcag agttcgtggt ggcttaggat cttcggatcg gccaccctcg cccctcgcac 60 cccagcccag ggcggcgggg actccgagag ccccggagag aacgtggccc agccctggag 120 ggcaggcggc cactccccca gccagaagtc tttttttctt ttcttctttt ttattatttt 180 tttctttttt taaaaagttc tgaccgtggt ttcctggact cttc atg ggc ttt gct 236 Met Gly Phe Ala 1 tcc tac ctc ctt cac cct tca ctc ctg ccc tcc tct tcc tcc tcc tcc 284 Ser Tyr Leu Leu His Pro Ser Leu Leu Pro Ser Ser Ser Ser Ser Ser 5 10 15 20 tcc tcc tct gtc tgt ctc ctt tca cct ctg cgc cag gtc ggt cct ccc 332 Ser Ser Ser Val Cys Leu Leu Ser Pro Leu Arg Gln Val Gly Pro Pro 25 30 35 tgc caa cct tcc cca gct cca ata tgt agc agt ctc tct gga tgg cgg 380 Cys Gln Pro Ser Pro Ala Pro Ile Cys Ser Ser Leu Ser Gly Trp Arg 40 45 50 aga gtg aag gag acg gag aaa cgc gcc cca tcc ctt ccg ccg cct cct 428 Arg Val Lys Glu Thr Glu Lys Arg Ala Pro Ser Leu Pro Pro Pro Pro 55 60 65 ttc ccc ccc gac cct att cag gtt tta agt caa aaa tgt cga tat gtc 476 Phe Pro Pro Asp Pro Ile Gln Val Leu Ser Gln Lys Cys Arg Tyr Val 70 75 80 att atg cac ttt aca gat gag ggg agg ggc cgc agt gcg cag aac cca 524 Ile Met His Phe Thr Asp Glu Gly Arg Gly Arg Ser Ala Gln Asn Pro 85 90 95 100 ccc cac ccc cca gtg cag act tcg ggg tct cca ccc cag gcc agc agc 572 Pro His Pro Pro Val Gln Thr Ser Gly Ser Pro Pro Gln Ala Ser Ser 105 110 115 gcc cac tgg gct aca gca agc caa cag gtc aca gaa gcc aac gag ggg 620 Ala His Trp Ala Thr Ala Ser Gln Gln Val Thr Glu Ala Asn Glu Gly 120 125 130 act gtt tct ctt cca ctc cta tcc tct tct tgatcttttt ttttgcattt 670 Thr Val Ser Leu Pro Leu Leu Ser Ser Ser 135 140 tccttcattt ctttaacaag gagagcaaag ctgttttagc agaggctggg gctgaggtcc 730 ccatggggtt tgggtgcagg ggcatggcac cctttcctgt cgggaaggga gaggggaact 790 acccccccag cctgccctcc gccccgcccc agccggcgga ctgtgctgtt tcctccgccc 850 ccactcccgt gttttctgac ctcctgcctg agtttggggt atttatagac tattaatttt 910 ctgactgagc caatagtggt tggggaactc ttgaaaaagg ggagagaatg gctgggtgct 970 ggggagttcc cccctccgag ccctccttcc cggcccaacc tgagggatgt ggatttggga 1030 ctgtctgggg gcccctcctg cagcgaggat gggagggggt gctgagctgt gaatcccctg 1090 ggcagggggc gacaactccg tgtagcatta acccccgtgg cggggtccgc tgctggtcta 1150 atttggaccc cctgcctctc agtgcccctg ccctaggggt gtctgtctcc agaggggagg 1210 gacaaatccc ctactggggc catttcaatg gggtagtttt tggatttttt tccccaccca 1270 ctttttattt tttaatgata atggagatgt ctggaccctt cctcacccca cctgtcggtc 1330 ttgtcctggc tctgcctgtc ccccaccgtt gttctcgtag gtgaacccca ggtcctcaac 1390 tccccccctt tatgtatgaa aacataaaat tgaaaaaaaa aaaaaaacct acacgagcac 1450 cgtgatttca agtaataaac agaaaatgaa acac 1484 <210> 226 <211> 142 <212> PRT <213> Homo sapiens <400> 226 Met Gly Phe Ala Ser Tyr Leu Leu His Pro Ser Leu Leu Pro Ser Ser 1 5 10 15 Ser Ser Ser Ser Ser Ser Ser Val Cys Leu Leu Ser Pro Leu Arg Gln 20 25 30 Val Gly Pro Pro Cys Gln Pro Ser Pro Ala Pro Ile Cys Ser Ser Leu 35 40 45 Ser Gly Trp Arg Arg Val Lys Glu Thr Glu Lys Arg Ala Pro Ser Leu 50 55 60 Pro Pro Pro Pro Phe Pro Pro Asp Pro Ile Gln Val Leu Ser Gln Lys 65 70 75 80 Cys Arg Tyr Val Ile Met His Phe Thr Asp Glu Gly Arg Gly Arg Ser 85 90 95 Ala Gln Asn Pro Pro His Pro Pro Val Gln Thr Ser Gly Ser Pro Pro 100 105 110 Gln Ala Ser Ser Ala His Trp Ala Thr Ala Ser Gln Gln Val Thr Glu 115 120 125 Ala Asn Glu Gly Thr Val Ser Leu Pro Leu Leu Ser Ser Ser 130 135 140 <210> 227 <211> 1656 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (26)..(1330) <400> 227 tgggcgcgcg cccgccccag ttatc atg gcg gct ccc ttg gtc ctg gtg ctg 52 Met Ala Ala Pro Leu Val Leu Val Leu 1 5 gtg gtg gct gtg aca gtg cgg gcg gcc ttg ttc cgc tcc agt ctg gcc 100 Val Val Ala Val Thr Val Arg Ala Ala Leu Phe Arg Ser Ser Leu Ala 10 15 20 25 gag ttc att tcc gag cgg gtg gag gtg gtg tcc cca ctg agc tct tgg 148 Glu Phe Ile Ser Glu Arg Val Glu Val Val Ser Pro Leu Ser Ser Trp 30 35 40 aag aga gtg gtt gaa ggc ctt tca ctg ttg gac ttg gga gta tct ccg 196 Lys Arg Val Val Glu Gly Leu Ser Leu Leu Asp Leu Gly Val Ser Pro 45 50 55 tat tct gga gca gta ttt cat gaa act cca tta ata ata tac ctc ttt 244 Tyr Ser Gly Ala Val Phe His Glu Thr Pro Leu Ile Ile Tyr Leu Phe 60 65 70 cat ttc cta att gac tat gct gaa ttg gtg ttt atg ata act gat gca 292 His Phe Leu Ile Asp Tyr Ala Glu Leu Val Phe Met Ile Thr Asp Ala 75 80 85 ctc act gct att gcc ctg tat ttt gca atc cag gac ttc aat aaa gtt 340 Leu Thr Ala Ile Ala Leu Tyr Phe Ala Ile Gln Asp Phe Asn Lys Val 90 95 100 105 gtg ttt aaa aag cag aaa ctc ctc cta gaa ctg gac cag tat gcc cca 388 Val Phe Lys Lys Gln Lys Leu Leu Leu Glu Leu Asp Gln Tyr Ala Pro 110 115 120 gat gtg gcc gaa ctc atc cgg acc cct atg gaa atg cgt tac atc cct 436 Asp Val Ala Glu Leu Ile Arg Thr Pro Met Glu Met Arg Tyr Ile Pro 125 130 135 ttg aaa gtg gcc ctg ttc tat ctc tta aat cct tac acg att ttg tct 484 Leu Lys Val Ala Leu Phe Tyr Leu Leu Asn Pro Tyr Thr Ile Leu Ser 140 145 150 tgt gtt gcc aag tct acc tgt gcc atc aac aac acc ctc att gct ttc 532 Cys Val Ala Lys Ser Thr Cys Ala Ile Asn Asn Thr Leu Ile Ala Phe 155 160 165 ttc att ttg act acg ata aaa ggc agt gct ttc ctc agt gct att ttt 580 Phe Ile Leu Thr Thr Ile Lys Gly Ser Ala Phe Leu Ser Ala Ile Phe 170 175 180 185 ctt gcc tta gcg aca tac cag tct ctg tac cca ctc acc ttg ttt gtc 628 Leu Ala Leu Ala Thr Tyr Gln Ser Leu Tyr Pro Leu Thr Leu Phe Val 190 195 200 cca gga ctc ctc tat ctc ctc cag cgg cag tac ata cct gtg aaa atg 676 Pro Gly Leu Leu Tyr Leu Leu Gln Arg Gln Tyr Ile Pro Val Lys Met 205 210 215 aag agc aaa gcc ttc tgg atc ttt tct tgg gag tat gcc atg atg tat 724 Lys Ser Lys Ala Phe Trp Ile Phe Ser Trp Glu Tyr Ala Met Met Tyr 220 225 230 gtg gga agc cta gtg gta atc att tgc ctc tcc ttc ttc ctt ctc agc 772 Val Gly Ser Leu Val Val Ile Ile Cys Leu Ser Phe Phe Leu Leu Ser 235 240 245 tct tgg gat ttc atc ccc gca gtc tat ggc ttt ata ctt tct gtt cca 820 Ser Trp Asp Phe Ile Pro Ala Val Tyr Gly Phe Ile Leu Ser Val Pro 250 255 260 265 gat ctc act cca aac att ggt ctt ttc tgg tac ttc ttt gca gag atg 868 Asp Leu Thr Pro Asn Ile Gly Leu Phe Trp Tyr Phe Phe Ala Glu Met 270 275 280 ttt gag cac ttc agc ctc ttc ttt gta tgt gtg ttt cag atc aac gtc 916 Phe Glu His Phe Ser Leu Phe Phe Val Cys Val Phe Gln Ile Asn Val 285 290 295 ttc ttc tac acc atc ccc tta gcc ata aag cta aag gag cac ccc atc 964 Phe Phe Tyr Thr Ile Pro Leu Ala Ile Lys Leu Lys Glu His Pro Ile 300 305 310 ttc ttc atg ttt atc cag atc gct gtc atc gcc atc ttt aag tcc tac 1012 Phe Phe Met Phe Ile Gln Ile Ala Val Ile Ala Ile Phe Lys Ser Tyr 315 320 325 ccg aca gtg ggg gac gtg gcg ctc tac atg gcc ttc ttc ccc gtg tgg 1060 Pro Thr Val Gly Asp Val Ala Leu Tyr Met Ala Phe Phe Pro Val Trp 330 335 340 345 aac cat ctc tac aga ttc ctg aga aac atc ttt gtc ctc acc tgc atc 1108 Asn His Leu Tyr Arg Phe Leu Arg Asn Ile Phe Val Leu Thr Cys Ile 350 355 360 atc atc gtc tgt tcc ctg ctc ttc cct gtc ctg tgg cac ctc tgg att 1156 Ile Ile Val Cys Ser Leu Leu Phe Pro Val Leu Trp His Leu Trp Ile 365 370 375 tat gca gga agt gcc aac tct aat ttc ttt tat gcc atc aca ctg acc 1204 Tyr Ala Gly Ser Ala Asn Ser Asn Phe Phe Tyr Ala Ile Thr Leu Thr 380 385 390 ttc aac gtt ggg cag atc ctg ctc atc tct gat tac ttc aat gcc ttc 1252 Phe Asn Val Gly Gln Ile Leu Leu Ile Ser Asp Tyr Phe Asn Ala Phe 395 400 405 ctg cgg cgg gag tac tac ctc aca cat ggc ctc tac ttg acc gcc aag 1300 Leu Arg Arg Glu Tyr Tyr Leu Thr His Gly Leu Tyr Leu Thr Ala Lys 410 415 420 425 gat ggc aca gag gcc atg ctc gtg ctc aag taggcctggc tggcacaggg 1350 Asp Gly Thr Glu Ala Met Leu Val Leu Lys 430 435 ctgcatggac ctcagggggc tgtggggcca gaagctgggc caagccctcc agccagagtt 1410 gccagcaggc gagtgcttgg gcagaagagg ttcgagtcca gggtcacaag tctctggtac 1470 caaaagggac ccatggctga ctgacagcaa ggcctatggg gaagaactgg gagctcccca 1530 acttggaccc ccaccttgtg gctctgcaca ccaaggagcc ccctcccaga caggaaggag 1590 aagaggcagg tgagcagggc ttgttagatt gtggctactt aataaatgtt ttttgttatg 1650 aagtct 1656 <210> 228 <211> 435 <212> PRT <213> Homo sapiens <400> 228 Met Ala Ala Pro Leu Val Leu Val Leu Val Val Ala Val Thr Val Arg 1 5 10 15 Ala Ala Leu Phe Arg Ser Ser Leu Ala Glu Phe Ile Ser Glu Arg Val 20 25 30 Glu Val Val Ser Pro Leu Ser Ser Trp Lys Arg Val Val Glu Gly Leu 35 40 45 Ser Leu Leu Asp Leu Gly Val Ser Pro Tyr Ser Gly Ala Val Phe His 50 55 60 Glu Thr Pro Leu Ile Ile Tyr Leu Phe His Phe Leu Ile Asp Tyr Ala 65 70 75 80 Glu Leu Val Phe Met Ile Thr Asp Ala Leu Thr Ala Ile Ala Leu Tyr 85 90 95 Phe Ala Ile Gln Asp Phe Asn Lys Val Val Phe Lys Lys Gln Lys Leu 100 105 110 Leu Leu Glu Leu Asp Gln Tyr Ala Pro Asp Val Ala Glu Leu Ile Arg 115 120 125 Thr Pro Met Glu Met Arg Tyr Ile Pro Leu Lys Val Ala Leu Phe Tyr 130 135 140 Leu Leu Asn Pro Tyr Thr Ile Leu Ser Cys Val Ala Lys Ser Thr Cys 145 150 155 160 Ala Ile Asn Asn Thr Leu Ile Ala Phe Phe Ile Leu Thr Thr Ile Lys 165 170 175 Gly Ser Ala Phe Leu Ser Ala Ile Phe Leu Ala Leu Ala Thr Tyr Gln 180 185 190 Ser Leu Tyr Pro Leu Thr Leu Phe Val Pro Gly Leu Leu Tyr Leu Leu 195 200 205 Gln Arg Gln Tyr Ile Pro Val Lys Met Lys Ser Lys Ala Phe Trp Ile 210 215 220 Phe Ser Trp Glu Tyr Ala Met Met Tyr Val Gly Ser Leu Val Val Ile 225 230 235 240 Ile Cys Leu Ser Phe Phe Leu Leu Ser Ser Trp Asp Phe Ile Pro Ala 245 250 255 Val Tyr Gly Phe Ile Leu Ser Val Pro Asp Leu Thr Pro Asn Ile Gly 260 265 270 Leu Phe Trp Tyr Phe Phe Ala Glu Met Phe Glu His Phe Ser Leu Phe 275 280 285 Phe Val Cys Val Phe Gln Ile Asn Val Phe Phe Tyr Thr Ile Pro Leu 290 295 300 Ala Ile Lys Leu Lys Glu His Pro Ile Phe Phe Met Phe Ile Gln Ile 305 310 315 320 Ala Val Ile Ala Ile Phe Lys Ser Tyr Pro Thr Val Gly Asp Val Ala 325 330 335 Leu Tyr Met Ala Phe Phe Pro Val Trp Asn His Leu Tyr Arg Phe Leu 340 345 350 Arg Asn Ile Phe Val Leu Thr Cys Ile Ile Ile Val Cys Ser Leu Leu 355 360 365 Phe Pro Val Leu Trp His Leu Trp Ile Tyr Ala Gly Ser Ala Asn Ser 370 375 380 Asn Phe Phe Tyr Ala Ile Thr Leu Thr Phe Asn Val Gly Gln Ile Leu 385 390 395 400 Leu Ile Ser Asp Tyr Phe Asn Ala Phe Leu Arg Arg Glu Tyr Tyr Leu 405 410 415 Thr His Gly Leu Tyr Leu Thr Ala Lys Asp Gly Thr Glu Ala Met Leu 420 425 430 Val Leu Lys 435 <210> 229 <211> 1754 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (355)..(1140) <400> 229 aaatttgcca ttcttagcaa ctggccagtc aacaactcaa ctttataatg ggaaaactag 60 acgagctgag attcaaccca cgtgagcggc tgcagagccg ctacccttaa cagctctctc 120 tcgggattct aacattccct tctgtgacgg agagacagca ggccgggaca cgcatcccag 180 gacggatcca cagctggatg gggaaggctg cgccaggcgg gccggaagcc tggcggtggc 240 gtgcaggagc cccgccctcc tgggctggat tcagccgggg gcggggccgc gggcggggcc 300 tgtggcagcg ggaatcccga ccccgcccct ttccccaccc ctccatttct cgcc atg 357 Met 1 gcc cct gca ctg ctc ctg atc cct gct gcc ctc gcc cct ttc atc ctg 405 Ala Pro Ala Leu Leu Leu Ile Pro Ala Ala Leu Ala Pro Phe Ile Leu 5 10 15 gcc ttt ggc acc gga gtg gag ttc gtg cgc ttt acc tcc ctt cgg cca 453 Ala Phe Gly Thr Gly Val Glu Phe Val Arg Phe Thr Ser Leu Arg Pro 20 25 30 ctt ctt gga ggg atc ccg gag tct ggt ggt ccg gat gcc cgc cag gga 501 Leu Leu Gly Gly Ile Pro Glu Ser Gly Gly Pro Asp Ala Arg Gln Gly 35 40 45 tgg ctg gct gcc ctg cag gac cgc agc atc ctt gcc ccc ctg gca tgg 549 Trp Leu Ala Ala Leu Gln Asp Arg Ser Ile Leu Ala Pro Leu Ala Trp 50 55 60 65 gat ctg ggg ctc ctg ctt cta ttt gtt ggg cag cac agc ctc atg gca 597 Asp Leu Gly Leu Leu Leu Leu Phe Val Gly Gln His Ser Leu Met Ala 70 75 80 gct gaa aga gtg aag gca tgg aca tcc cgg tac ttt ggg gtc ctt cag 645 Ala Glu Arg Val Lys Ala Trp Thr Ser Arg Tyr Phe Gly Val Leu Gln 85 90 95 agg tca ctg tat gtg gcc tgc act gcc ctg gcc ttg cag ctg gtg atg 693 Arg Ser Leu Tyr Val Ala Cys Thr Ala Leu Ala Leu Gln Leu Val Met 100 105 110 cgg tac tgg gag ccc ata ccc aaa ggc cct gtg ttg tgg gag gct cgg 741 Arg Tyr Trp Glu Pro Ile Pro Lys Gly Pro Val Leu Trp Glu Ala Arg 115 120 125 gct gag cca tgg gcc acc tgg gtg ccg ctc ctc tgc ttt gtg ctc cat 789 Ala Glu Pro Trp Ala Thr Trp Val Pro Leu Leu Cys Phe Val Leu His 130 135 140 145 gtc atc tcc tgg ctc ctc atc ttt agc atc ctt ctc gtc ttt gac tat 837 Val Ile Ser Trp Leu Leu Ile Phe Ser Ile Leu Leu Val Phe Asp Tyr 150 155 160 gct gag ctc atg ggc ctc aaa cag gta tac tac cat gtg ctg ggg ctg 885 Ala Glu Leu Met Gly Leu Lys Gln Val Tyr Tyr His Val Leu Gly Leu 165 170 175 ggc gag cct ctg gcc ctg aag tct ccc cgg gct ctc aga ctc ttc tcc 933 Gly Glu Pro Leu Ala Leu Lys Ser Pro Arg Ala Leu Arg Leu Phe Ser 180 185 190 cac ctg cgc cac cca gtg tgt gtg gag ctg ctg aca gtg ctg tgg gtg 981 His Leu Arg His Pro Val Cys Val Glu Leu Leu Thr Val Leu Trp Val 195 200 205 gtg cct acc ctg ggc acg gac cgt ctc ctc ctt gct ttc ctc ctt acc 1029 Val Pro Thr Leu Gly Thr Asp Arg Leu Leu Leu Ala Phe Leu Leu Thr 210 215 220 225 ctc tac ctg ggc ctg gct cac ggg ctt gat cag caa gac ctc cgc tac 1077 Leu Tyr Leu Gly Leu Ala His Gly Leu Asp Gln Gln Asp Leu Arg Tyr 230 235 240 ctc cgg gcc cag cta caa aga aaa ctc cac ctg ctc tct cgg ccc cag 1125 Leu Arg Ala Gln Leu Gln Arg Lys Leu His Leu Leu Ser Arg Pro Gln 245 250 255 gat ggg gag gca gag tgaggagctc actctggtta caagccctgt tcttcctctc 1180 Asp Gly Glu Ala Glu 260 ccactgaatt ctaaatcctt aacatccagg ccctggctgc ttcatgccag aggcccaaat 1240 ccatggactg aaggagatgc cccttctact acttgagact ttattctctg ggtccagctc 1300 cataccctaa attctgagtt tcagccactg aactccaagg tccacttctc accagcaagg 1360 aagagtgggg tatggaagtc atctgtccct tcactgttta gagcatgaca ctctccccct 1420 caacagcctc ctgagaagga aaggatctgc cctgaccact cccctggcac tgttacttgc 1480 ctctgcgcct caggggtccc cttctgcacc gctggcttcc actccaagaa ggtggaccag 1540 ggtctgcaag ttcaacggtc atagctgtcc ctccaggccc caaccttgcc tcaccactcc 1600 cggccctagt ctctgcacct ccttaggccc tgcctctggg ctcagacccc aacctagtca 1660 aggggattct cctgctctta actcgatgac ttggggctcc ctgctctccc gaggaagatg 1720 ctctgcagga aaataaaagt cagccttttt ctac 1754 <210> 230 <211> 262 <212> PRT <213> Homo sapiens <400> 230 Met Ala Pro Ala Leu Leu Leu Ile Pro Ala Ala Leu Ala Pro Phe Ile 1 5 10 15 Leu Ala Phe Gly Thr Gly Val Glu Phe Val Arg Phe Thr Ser Leu Arg 20 25 30 Pro Leu Leu Gly Gly Ile Pro Glu Ser Gly Gly Pro Asp Ala Arg Gln 35 40 45 Gly Trp Leu Ala Ala Leu Gln Asp Arg Ser Ile Leu Ala Pro Leu Ala 50 55 60 Trp Asp Leu Gly Leu Leu Leu Leu Phe Val Gly Gln His Ser Leu Met 65 70 75 80 Ala Ala Glu Arg Val Lys Ala Trp Thr Ser Arg Tyr Phe Gly Val Leu 85 90 95 Gln Arg Ser Leu Tyr Val Ala Cys Thr Ala Leu Ala Leu Gln Leu Val 100 105 110 Met Arg Tyr Trp Glu Pro Ile Pro Lys Gly Pro Val Leu Trp Glu Ala 115 120 125 Arg Ala Glu Pro Trp Ala Thr Trp Val Pro Leu Leu Cys Phe Val Leu 130 135 140 His Val Ile Ser Trp Leu Leu Ile Phe Ser Ile Leu Leu Val Phe Asp 145 150 155 160 Tyr Ala Glu Leu Met Gly Leu Lys Gln Val Tyr Tyr His Val Leu Gly 165 170 175 Leu Gly Glu Pro Leu Ala Leu Lys Ser Pro Arg Ala Leu Arg Leu Phe 180 185 190 Ser His Leu Arg His Pro Val Cys Val Glu Leu Leu Thr Val Leu Trp 195 200 205 Val Val Pro Thr Leu Gly Thr Asp Arg Leu Leu Leu Ala Phe Leu Leu 210 215 220 Thr Leu Tyr Leu Gly Leu Ala His Gly Leu Asp Gln Gln Asp Leu Arg 225 230 235 240 Tyr Leu Arg Ala Gln Leu Gln Arg Lys Leu His Leu Leu Ser Arg Pro 245 250 255 Gln Asp Gly Glu Ala Glu 260 <210> 231 <211> 2144 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (97)..(654) <400> 231 aggaagagca gcggcgaggc ggcggtggtg gctgagtccg tggtggcaga ggcgaaggcg 60 acagctctag gggttggcac cggccccgag aggagg atg cgg gtc cgg ata ggg 114 Met Arg Val Arg Ile Gly 1 5 ctg acg ctg ctg ctg tgt gcg gtg ctg ctg agc ttg gcc tcg gcg tcc 162 Leu Thr Leu Leu Leu Cys Ala Val Leu Leu Ser Leu Ala Ser Ala Ser 10 15 20 tcg gat gaa gaa ggc agc cag gat gaa tcc tta gat tcc aag act act 210 Ser Asp Glu Glu Gly Ser Gln Asp Glu Ser Leu Asp Ser Lys Thr Thr 25 30 35 ttg aca tca gat gag tca gta aag gac cat act act gca ggc aga gta 258 Leu Thr Ser Asp Glu Ser Val Lys Asp His Thr Thr Ala Gly Arg Val 40 45 50 gtt gct ggt caa ata ttt ctt gat tca gaa gaa tct gaa tta gaa tcc 306 Val Ala Gly Gln Ile Phe Leu Asp Ser Glu Glu Ser Glu Leu Glu Ser 55 60 65 70 tct att caa gaa gag gaa gac agc ctc aag agc caa gag ggg gaa agt 354 Ser Ile Gln Glu Glu Glu Asp Ser Leu Lys Ser Gln Glu Gly Glu Ser 75 80 85 gtc aca gaa gat atc agc ttt cta gag tct cca aat cca gaa aac aag 402 Val Thr Glu Asp Ile Ser Phe Leu Glu Ser Pro Asn Pro Glu Asn Lys 90 95 100 gac tat gaa gag cca aag aaa gta cgg aaa cca gct ttg acc gcc att 450 Asp Tyr Glu Glu Pro Lys Lys Val Arg Lys Pro Ala Leu Thr Ala Ile 105 110 115 gaa ggc aca gca cat ggg gag ccc tgc cac ttc cct ttt ctt ttc cta 498 Glu Gly Thr Ala His Gly Glu Pro Cys His Phe Pro Phe Leu Phe Leu 120 125 130 gat aag gag tat gat gaa tgt aca tca gat ggg agg gaa gat ggc aga 546 Asp Lys Glu Tyr Asp Glu Cys Thr Ser Asp Gly Arg Glu Asp Gly Arg 135 140 145 150 ctg tgg tgt gct aca acc tat gac tac aaa gca gat gaa aag tgg ggc 594 Leu Trp Cys Ala Thr Thr Tyr Asp Tyr Lys Ala Asp Glu Lys Trp Gly 155 160 165 ttt tgt gaa act gaa gaa gag gct gct aag aga cgg cag atg cag gaa 642 Phe Cys Glu Thr Glu Glu Glu Ala Ala Lys Arg Arg Gln Met Gln Glu 170 175 180 gca gaa atg atg taacaaactg gaatgaaaat ccttaatgga agcaataaga 694 Ala Glu Met Met 185 aaagccaaaa aagagaagca tatcggtatc tccaaaaggc agcaagcatg aaccatacca 754 aagccctgga gagagtgtca tatgctcttt tatttggtga ttacttgcca cagaatatcc 814 aggcagcgag agagatgttt gagaagctga ctgaggaagg ctctcccaag ggacagactg 874 ctcttggctt tctgtatgcc tctggacttg gtgttaattc aagtcaggca aaggctcttg 934 tatattatac atttggagct cttgggggca atctaatagc ccacatggtt ttgggttaca 994 gatactgggc tggcatcggc gtcctccaga gttgtgaatc tgccctgact cactatcgtc 1054 ttgttgccaa tcatgttgct agtgatatct cgctaacagg aggctcagta gtacagagaa 1114 tacggctgcc tgatgaagtg gaaaatccag gaatgaacag tggaatgcta gaagaagatt 1174 tgattcaata ttaccagttc ctagctgaaa aaggtgatgt acaagcacag gttggtcttg 1234 gacaactgca cctgcacgga gggcgtggag tagaacagaa tcatcagaga gcatttgact 1294 acttcaattt agcagcaaat gctggcaatt cacatgccat ggcctttttg ggaaagatgt 1354 attcggaagg aagtgacatt gtacctcaga gtaatgagac agctctccac tactttaaga 1414 aagctgctga catgggcaac ccagttggac agagtgggct tggaatggcc tacctctatg 1474 ggagaggagt tcaagttaat tatgatctag cccttaagta tttccagaaa gctgctgaac 1534 aaggctgggt ggatgggcag ctacagcttg gttccatgta ctataatggc attggagtca 1594 agagagatta taaacaggcc ttgaagtatt ttaatttagc ttctcaggga ggccatatct 1654 tggctttcta taacctagct cagatgcatg ccagtggcac cggcgtgatg cgatcatgtc 1714 acactgcagt ggagttgttt aagaatgtat gtgaacgagg ccgttggtct gaaaggctta 1774 tgactgccta taacagctat aaagatggcg attacaatac tgctgtgtaa tgggctttgt 1834 acgttccttc tcatgtcact tacgtcacta cttcgccatc aaattgaaca agcttttaat 1894 tagatcctga aaattcacta tgctagtagt ttattggtag tattatattt tgagtagaac 1954 tctgattttc cctagaggcc aaattctttt tatctgggtt aatttctttt aaacataaca 2014 atgttaacgc tgaattgtat attaaatccc atttctaaaa accacacaat tttttctcat 2074 gtaagttgag tggaatgtgg ttagttaact gaatttggaa tgttcatata aataatttgt 2134 tgctgctcat 2144 <210> 232 <211> 186 <212> PRT <213> Homo sapiens <400> 232 Met Arg Val Arg Ile Gly Leu Thr Leu Leu Leu Cys Ala Val Leu Leu 1 5 10 15 Ser Leu Ala Ser Ala Ser Ser Asp Glu Glu Gly Ser Gln Asp Glu Ser 20 25 30 Leu Asp Ser Lys Thr Thr Leu Thr Ser Asp Glu Ser Val Lys Asp His 35 40 45 Thr Thr Ala Gly Arg Val Val Ala Gly Gln Ile Phe Leu Asp Ser Glu 50 55 60 Glu Ser Glu Leu Glu Ser Ser Ile Gln Glu Glu Glu Asp Ser Leu Lys 65 70 75 80 Ser Gln Glu Gly Glu Ser Val Thr Glu Asp Ile Ser Phe Leu Glu Ser 85 90 95 Pro Asn Pro Glu Asn Lys Asp Tyr Glu Glu Pro Lys Lys Val Arg Lys 100 105 110 Pro Ala Leu Thr Ala Ile Glu Gly Thr Ala His Gly Glu Pro Cys His 115 120 125 Phe Pro Phe Leu Phe Leu Asp Lys Glu Tyr Asp Glu Cys Thr Ser Asp 130 135 140 Gly Arg Glu Asp Gly Arg Leu Trp Cys Ala Thr Thr Tyr Asp Tyr Lys 145 150 155 160 Ala Asp Glu Lys Trp Gly Phe Cys Glu Thr Glu Glu Glu Ala Ala Lys 165 170 175 Arg Arg Gln Met Gln Glu Ala Glu Met Met 180 185 <210> 233 <211> 1689 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (113)..(1159) <400> 233 cattctgagt atccttgaag tcattatcat cttgctgctc atctttctcc ggaagagaat 60 tctcatcgcg attgcactca tcaaagaagc cagcagggct gtgggatacg tc atg tgc 118 Met Cys 1 tcc ttg ctc tac cca ctg gtc acc ttc ttc ttg ctg tgc ctc tgc atc 166 Ser Leu Leu Tyr Pro Leu Val Thr Phe Phe Leu Leu Cys Leu Cys Ile 5 10 15 gcc tac tgg gcc agc act gct gtc ttc ctg tcc act tcc aac gaa gcg 214 Ala Tyr Trp Ala Ser Thr Ala Val Phe Leu Ser Thr Ser Asn Glu Ala 20 25 30 gtc tat aag atc ttt gat gac agc ccc tgc cca ttt act gcg aaa acc 262 Val Tyr Lys Ile Phe Asp Asp Ser Pro Cys Pro Phe Thr Ala Lys Thr 35 40 45 50 tgc aac cca gag acc ttc ccc tcc tcc aat gag tcc cgc caa tgc ccc 310 Cys Asn Pro Glu Thr Phe Pro Ser Ser Asn Glu Ser Arg Gln Cys Pro 55 60 65 aat gcc cgt tgc cag ttc gcc ttc tac ggt ggt gag tcg ggc tac cac 358 Asn Ala Arg Cys Gln Phe Ala Phe Tyr Gly Gly Glu Ser Gly Tyr His 70 75 80 cgg gcc ctg ctg ggc ctg cag atc ttc aat gcc ttc atg ttc ttc tgg 406 Arg Ala Leu Leu Gly Leu Gln Ile Phe Asn Ala Phe Met Phe Phe Trp 85 90 95 ttg gcc aac ttc gtg ctg gcg ctg ggc cag gtc acg ctg gcc ggg gcc 454 Leu Ala Asn Phe Val Leu Ala Leu Gly Gln Val Thr Leu Ala Gly Ala 100 105 110 ttt gcc tcc tac tac tgg gcc ctg cgc aag ccg gac gac ctg ccg gcc 502 Phe Ala Ser Tyr Tyr Trp Ala Leu Arg Lys Pro Asp Asp Leu Pro Ala 115 120 125 130 ttc ccg ctc ttc tct gcc ttt ggc cgg gcg ctc agg tac cac aca ggc 550 Phe Pro Leu Phe Ser Ala Phe Gly Arg Ala Leu Arg Tyr His Thr Gly 135 140 145 tcc ctg gcc ttt ggc gcg ctc atc ctg gcc att gtg cag atc atc cgt 598 Ser Leu Ala Phe Gly Ala Leu Ile Leu Ala Ile Val Gln Ile Ile Arg 150 155 160 gtg ata ctc gag tac ctg gat cag cgg ctg aaa gct gca gag aac aag 646 Val Ile Leu Glu Tyr Leu Asp Gln Arg Leu Lys Ala Ala Glu Asn Lys 165 170 175 ttt gcc aag tgc ctc atg acc tgt ctc aaa tgc tgc ttc tgg tgc ctg 694 Phe Ala Lys Cys Leu Met Thr Cys Leu Lys Cys Cys Phe Trp Cys Leu 180 185 190 gag aag ttc atc aaa ttc ctt aat agg aat gcc tac atc atg att gcc 742 Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr Ile Met Ile Ala 195 200 205 210 atc tac ggc acc aat ttc tgc acc tcg gcc agg aat gcc ttc ttc ctg 790 Ile Tyr Gly Thr Asn Phe Cys Thr Ser Ala Arg Asn Ala Phe Phe Leu 215 220 225 ctc atg aga aac atc atc aga gtg gct gtc ctg gat aaa gtt act gac 838 Leu Met Arg Asn Ile Ile Arg Val Ala Val Leu Asp Lys Val Thr Asp 230 235 240 ttc ctc ttc ctg ttg ggc aaa ctt ctg atc gtt ggt agt gtg ggg atc 886 Phe Leu Phe Leu Leu Gly Lys Leu Leu Ile Val Gly Ser Val Gly Ile 245 250 255 ctg gct ttc ttc ttc ttc acc cac cgt atc agg atc gtg cag gat aca 934 Leu Ala Phe Phe Phe Phe Thr His Arg Ile Arg Ile Val Gln Asp Thr 260 265 270 gca cca ccc ctc aat tat tac tgg gtt cct ata ctg acg gtg atc gtt 982 Ala Pro Pro Leu Asn Tyr Tyr Trp Val Pro Ile Leu Thr Val Ile Val 275 280 285 290 ggc tcc tac ttg att gca cac ggt ttc ttc agc gtc tat ggc atg tgt 1030 Gly Ser Tyr Leu Ile Ala His Gly Phe Phe Ser Val Tyr Gly Met Cys 295 300 305 gtg gac acg ctg ttc ctc tgc ttc ttg gag gac ctg gag agg aat gac 1078 Val Asp Thr Leu Phe Leu Cys Phe Leu Glu Asp Leu Glu Arg Asn Asp 310 315 320 ggc tcg gcc gag agg cct tac ttc atg tct tcc acc ctc aag aaa ctc 1126 Gly Ser Ala Glu Arg Pro Tyr Phe Met Ser Ser Thr Leu Lys Lys Leu 325 330 335 ttg aac aag acc aac aag aag gca gcg gag tcc tgaaggcccc gtgctcccca 1179 Leu Asn Lys Thr Asn Lys Lys Ala Ala Glu Ser 340 345 cctctcaagg agtctcatgc cgcagggtgc tcagtagctg ggtctgttcc cccagcccct 1239 tgggctcacc tgaagtccta tcactgccgc tctgcccctc cccatgagcc agatcccacc 1299 agtttctgga cgtggagagt ctggggcatc tccttcttat gccaaggggc gcttggagtt 1359 ttcatggctg cccctccaga ctgcgagaaa caagtaaaaa cccattgggg cctcttgatg 1419 tctgggatgg cacgtggccc gacctccaca agctccctca tgcttcctgt cccccgctta 1479 cacgacaacg ggccagacca cgggaaggac ggtgtttgtg tctgagggag ctgctggccg 1539 cagtgaacac ccacgtttat tcctgcctgc tccggccagg actgaacccc ttctccacac 1599 ctgaacagtt ggctcaaggg ccaccagaag catttcttta ttattattat tttttaacct 1659 ggacatgcat taaagggtct attagctttc 1689 <210> 234 <211> 349 <212> PRT <213> Homo sapiens <400> 234 Met Cys Ser Leu Leu Tyr Pro Leu Val Thr Phe Phe Leu Leu Cys Leu 1 5 10 15 Cys Ile Ala Tyr Trp Ala Ser Thr Ala Val Phe Leu Ser Thr Ser Asn 20 25 30 Glu Ala Val Tyr Lys Ile Phe Asp Asp Ser Pro Cys Pro Phe Thr Ala 35 40 45 Lys Thr Cys Asn Pro Glu Thr Phe Pro Ser Ser Asn Glu Ser Arg Gln 50 55 60 Cys Pro Asn Ala Arg Cys Gln Phe Ala Phe Tyr Gly Gly Glu Ser Gly 65 70 75 80 Tyr His Arg Ala Leu Leu Gly Leu Gln Ile Phe Asn Ala Phe Met Phe 85 90 95 Phe Trp Leu Ala Asn Phe Val Leu Ala Leu Gly Gln Val Thr Leu Ala 100 105 110 Gly Ala Phe Ala Ser Tyr Tyr Trp Ala Leu Arg Lys Pro Asp Asp Leu 115 120 125 Pro Ala Phe Pro Leu Phe Ser Ala Phe Gly Arg Ala Leu Arg Tyr His 130 135 140 Thr Gly Ser Leu Ala Phe Gly Ala Leu Ile Leu Ala Ile Val Gln Ile 145 150 155 160 Ile Arg Val Ile Leu Glu Tyr Leu Asp Gln Arg Leu Lys Ala Ala Glu 165 170 175 Asn Lys Phe Ala Lys Cys Leu Met Thr Cys Leu Lys Cys Cys Phe Trp 180 185 190 Cys Leu Glu Lys Phe Ile Lys Phe Leu Asn Arg Asn Ala Tyr Ile Met 195 200 205 Ile Ala Ile Tyr Gly Thr Asn Phe Cys Thr Ser Ala Arg Asn Ala Phe 210 215 220 Phe Leu Leu Met Arg Asn Ile Ile Arg Val Ala Val Leu Asp Lys Val 225 230 235 240 Thr Asp Phe Leu Phe Leu Leu Gly Lys Leu Leu Ile Val Gly Ser Val 245 250 255 Gly Ile Leu Ala Phe Phe Phe Phe Thr His Arg Ile Arg Ile Val Gln 260 265 270 Asp Thr Ala Pro Pro Leu Asn Tyr Tyr Trp Val Pro Ile Leu Thr Val 275 280 285 Ile Val Gly Ser Tyr Leu Ile Ala His Gly Phe Phe Ser Val Tyr Gly 290 295 300 Met Cys Val Asp Thr Leu Phe Leu Cys Phe Leu Glu Asp Leu Glu Arg 305 310 315 320 Asn Asp Gly Ser Ala Glu Arg Pro Tyr Phe Met Ser Ser Thr Leu Lys 325 330 335 Lys Leu Leu Asn Lys Thr Asn Lys Lys Ala Ala Glu Ser 340 345 <210> 235 <211> 1824 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (10)..(978) <400> 235 ctcgcagcc atg gcg gcc gcc gcg ctc cca gca tgg ctg tct ctg cag tcg 51 Met Ala Ala Ala Ala Leu Pro Ala Trp Leu Ser Leu Gln Ser 1 5 10 agg gca agg act ctg cgt gca ttc tcc act gcc gtc tac tcg gcc act 99 Arg Ala Arg Thr Leu Arg Ala Phe Ser Thr Ala Val Tyr Ser Ala Thr 15 20 25 30 ccg gtc ccg aca cct agc ctg ccg gaa aga aca ccc gga aat gaa agg 147 Pro Val Pro Thr Pro Ser Leu Pro Glu Arg Thr Pro Gly Asn Glu Arg 35 40 45 cca cca aga aga aag gca cta cct cct agg aca gag aaa atg gct gtt 195 Pro Pro Arg Arg Lys Ala Leu Pro Pro Arg Thr Glu Lys Met Ala Val 50 55 60 gac cag gac tgg cct agt gtt tac cca gtt gca gca cca ttt aaa ccc 243 Asp Gln Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro Phe Lys Pro 65 70 75 tct gca gta cct ctt cct gtt cga atg ggt tat cca gta aaa aag ggc 291 Ser Ala Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val Lys Lys Gly 80 85 90 gtg ccc atg gca aag gag gga aat cta gaa ctt tta aag att ccc aat 339 Val Pro Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys Ile Pro Asn 95 100 105 110 ttt ctg cat ttg act cct gta gca att aaa aag cac tgt gaa gcc ctt 387 Phe Leu His Leu Thr Pro Val Ala Ile Lys Lys His Cys Glu Ala Leu 115 120 125 aaa gat ttt tgc act gag tgg cca gcc gca ctg gac agt gac gag aaa 435 Lys Asp Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser Asp Glu Lys 130 135 140 tgt gag aag cat ttt cca att gaa att gac agc act gat tat gtt tca 483 Cys Glu Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp Tyr Val Ser 145 150 155 tca gga cca tct gtt cgg aac ccc aga gca cga gta gta gtc tta aga 531 Ser Gly Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val Val Leu Arg 160 165 170 gta aag ctt tcc agt ttg aat tta gat gat cac gca aag aag aaa tta 579 Val Lys Leu Ser Ser Leu Asn Leu Asp Asp His Ala Lys Lys Lys Leu 175 180 185 190 att aaa ctt gta gga gag cga tac tgc aag acc aca gat gtg ctt acc 627 Ile Lys Leu Val Gly Glu Arg Tyr Cys Lys Thr Thr Asp Val Leu Thr 195 200 205 atc aaa aca gat agg tgc cct tta agg agg cag aat tac gat tat gca 675 Ile Lys Thr Asp Arg Cys Pro Leu Arg Arg Gln Asn Tyr Asp Tyr Ala 210 215 220 gtg tat cta cta aca gtg tta tac cat gag tct tgg aat act gaa gaa 723 Val Tyr Leu Leu Thr Val Leu Tyr His Glu Ser Trp Asn Thr Glu Glu 225 230 235 tgg gaa aaa agt aag act gaa gca gac atg gaa gag tat ata tgg gaa 771 Trp Glu Lys Ser Lys Thr Glu Ala Asp Met Glu Glu Tyr Ile Trp Glu 240 245 250 aat agc tca tca gaa aga aat atc ctg gaa acg ctt ctc cag atg aaa 819 Asn Ser Ser Ser Glu Arg Asn Ile Leu Glu Thr Leu Leu Gln Met Lys 255 260 265 270 gct gct gag aaa aat atg gaa ata aat aaa gaa gag ctc ctt ggt act 867 Ala Ala Glu Lys Asn Met Glu Ile Asn Lys Glu Glu Leu Leu Gly Thr 275 280 285 aaa gaa att gaa gag tac aaa aag tct gtt gtt agt ctt aaa aat gag 915 Lys Glu Ile Glu Glu Tyr Lys Lys Ser Val Val Ser Leu Lys Asn Glu 290 295 300 gag gaa aat gaa aat tcc att tct cag tac aaa gaa tcc gtg aag aga 963 Glu Glu Asn Glu Asn Ser Ile Ser Gln Tyr Lys Glu Ser Val Lys Arg 305 310 315 cta tta aat gtg aca tgaattatgg agtagaaaaa tctgcttgat ttattaattt 1018 Leu Leu Asn Val Thr 320 tatgatatat gtgatcagta tctaatttga tataaaattg aaaatgttaa aaaatcattt 1078 tttttcctca gagttaaaat tatttccctc atactaatgc ttaatggcaa tgattactcc 1138 agagtttttt aatttttaca ctggggcaat agactaggag gtctctgatt tcttcttggt 1198 ctaaagtgtt ttgattttat ttctacataa tagctttggt attcatgtat atacatgcat 1258 ttaattgtga ttttatcacc tttcccattt ctttccccac aagctggcat ttcagtagtt 1318 gcttttgaat aatggttttg gttacctggg aaggcaggcc cagaacccat ttccttgact 1378 tgcagttccg ggctgtgttc acatgactgc tgtctagctg atgcattttt cacatttgtc 1438 aactctggtt agaaacaggt cctcaggagt attctctaac ctgatatttt ctaaaaagat 1498 atgttgattc aactttgttt agcatcctac tttctagatt gtggggctca ttttgccagg 1558 gccaagctac cagaaaagta gaagtggaga ttacctggta tgtatctctc tgggtgcccc 1618 agttagagct gccacagctc aggaaaaaga tgaggcataa cgaccttgaa tgtaattgga 1678 gtaagtgaca aaataagaac taccctggga aaccctgcat tcaatgtagc tgtcaattca 1738 gtatttttaa gtacacctgt cagctgtttc ttaccacttc gatggttgtg attaatttaa 1798 aatcaaaata aaggaattac tgagtt 1824 <210> 236 <211> 323 <212> PRT <213> Homo sapiens <400> 236 Met Ala Ala Ala Ala Leu Pro Ala Trp Leu Ser Leu Gln Ser Arg Ala 1 5 10 15 Arg Thr Leu Arg Ala Phe Ser Thr Ala Val Tyr Ser Ala Thr Pro Val 20 25 30 Pro Thr Pro Ser Leu Pro Glu Arg Thr Pro Gly Asn Glu Arg Pro Pro 35 40 45 Arg Arg Lys Ala Leu Pro Pro Arg Thr Glu Lys Met Ala Val Asp Gln 50 55 60 Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro Phe Lys Pro Ser Ala 65 70 75 80 Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val Lys Lys Gly Val Pro 85 90 95 Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys Ile Pro Asn Phe Leu 100 105 110 His Leu Thr Pro Val Ala Ile Lys Lys His Cys Glu Ala Leu Lys Asp 115 120 125 Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser Asp Glu Lys Cys Glu 130 135 140 Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp Tyr Val Ser Ser Gly 145 150 155 160 Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val Val Leu Arg Val Lys 165 170 175 Leu Ser Ser Leu Asn Leu Asp Asp His Ala Lys Lys Lys Leu Ile Lys 180 185 190 Leu Val Gly Glu Arg Tyr Cys Lys Thr Thr Asp Val Leu Thr Ile Lys 195 200 205 Thr Asp Arg Cys Pro Leu Arg Arg Gln Asn Tyr Asp Tyr Ala Val Tyr 210 215 220 Leu Leu Thr Val Leu Tyr His Glu Ser Trp Asn Thr Glu Glu Trp Glu 225 230 235 240 Lys Ser Lys Thr Glu Ala Asp Met Glu Glu Tyr Ile Trp Glu Asn Ser 245 250 255 Ser Ser Glu Arg Asn Ile Leu Glu Thr Leu Leu Gln Met Lys Ala Ala 260 265 270 Glu Lys Asn Met Glu Ile Asn Lys Glu Glu Leu Leu Gly Thr Lys Glu 275 280 285 Ile Glu Glu Tyr Lys Lys Ser Val Val Ser Leu Lys Asn Glu Glu Glu 290 295 300 Asn Glu Asn Ser Ile Ser Gln Tyr Lys Glu Ser Val Lys Arg Leu Leu 305 310 315 320 Asn Val Thr <210> 237 <211> 1959 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (56)..(478) <400> 237 gcacttcagc ttcccctccc ccggcgccct ctggggctcc gagcccggcg ggacc atg 58 Met 1 ttc acc agc acc ggc tcc agt ggg ctc tac aag gcg cct ctg tcg aag 106 Phe Thr Ser Thr Gly Ser Ser Gly Leu Tyr Lys Ala Pro Leu Ser Lys 5 10 15 agc ctt ctg ctg gtc ccc agt gcc ctc tcc ctc ctg ctc gcc ctc ctc 154 Ser Leu Leu Leu Val Pro Ser Ala Leu Ser Leu Leu Leu Ala Leu Leu 20 25 30 ctg cct cac tgc cag aag ctc ttt gtg tat gac ctt cac gca gtc aag 202 Leu Pro His Cys Gln Lys Leu Phe Val Tyr Asp Leu His Ala Val Lys 35 40 45 aac gac ttc cag cct ggc acc tgt gtt tgc tct gtt tgt acc att tta 250 Asn Asp Phe Gln Pro Gly Thr Cys Val Cys Ser Val Cys Thr Ile Leu 50 55 60 65 ctg ctc cat acc aag agt cca agt ggc aca aat tct ggg tcc gtt gtc 298 Leu Leu His Thr Lys Ser Pro Ser Gly Thr Asn Ser Gly Ser Val Val 70 75 80 cat cac aaa caa gac att gat tta tat att ggg act gca gct ttt cac 346 His His Lys Gln Asp Ile Asp Leu Tyr Ile Gly Thr Ala Ala Phe His 85 90 95 ctc tgg ttc cta cat ctg gat tgt agc cat aag tgg act tat gtc cgg 394 Leu Trp Phe Leu His Leu Asp Cys Ser His Lys Trp Thr Tyr Val Arg 100 105 110 tct gtg cta cga cag caa aat gtt cca ggt gca tca ggt gct ctg cat 442 Ser Val Leu Arg Gln Gln Asn Val Pro Gly Ala Ser Gly Ala Leu His 115 120 125 ccc cag ctg gat ggc aaa att ctt ttc ttg gac act tgaacccatc 488 Pro Gln Leu Asp Gly Lys Ile Leu Phe Leu Asp Thr 130 135 140 ttctcttctt cagaacccac cagcgaagcc agaattggga tgggagccac gctggacatc 548 cagagacagc agagaatgga gctgctggac cggcagctga tgttctctca gtttgcacaa 608 gggaggcgac agagacagca gcagggagga atgatcaatt ggaatcgtct ttttcctcct 668 ttacgtcagc gacaaaacgt aaactatcag ggcggtcggc agtctgagcc agcagcgccc 728 cctctagaag tttctgagga acaggtcgcc cggctcatgg agatgggatt ttccaagagg 788 tgatgctttg gaagccctga gagcttcaaa caatgacctc aatgtcgcca ccaacttcct 848 gctgcagcac tgatagtccc aggccaacac tgggaccgga ccggcagccg agtgacagtg 908 cgtggtcccc accatcagat cagcccgggg accgagcatc tctggtgctg atgttcttgt 968 gggaagaggg aggttccacc gcacccctgc cctcaaccgc aagactgttg ccgttttagt 1028 gtggagataa gtttgccatt acattagcat gtattttcta tctatatttt tattgggcat 1088 tttccctagg ttggagagtc agcactcgtt ttgaatgtgt ttaaaatgca ttaaaatgga 1148 agatttctgc aggcagttga atggcactcc agatggggaa ttgctgtaac cctcttactg 1208 taacatgtca tctcctgcgt cgtgatgggg agagggtaat gttacttcac aaaggacatg 1268 tcagatcctt cttcatggac ttttttagtt actgtttttt ctctcaaact tgttttcgaa 1328 tctcctggga gtgagggaga aacagggagc tgaatcctcc cccaagctgt tccaggccag 1388 aggactctgc agtaccttct cctacatcta gtaacaaaga atggtgataa ccatgcactg 1448 gttcaaggtt ctggagttct ccatgaaact tgggttaatt ttgctcagag tatccagagt 1508 tagccactag gctgcgggtg aaatgggatg gagaagaaca acagcgggct tcctggagcc 1568 acatgggctg actagggcac tctgtggctg gcctggcatg ggctcagccc aggaagagga 1628 gaaacgatcc cttgcctgcc cctccctgtg gcagggctaa ctgcctggcc ctcctggctc 1688 gcagccagcc agccccctgg cagcaggttc tcctcagggc ttgggtcttc aacctgtggc 1748 gacaggaggc agggcagact gtggaggaca ggatgcaggt cagggagagg gaaggcaggg 1808 gtggaccgcc atgagcatga aaagacccga agcaagttga ctcttgcaat gtgcaactgt 1868 tatgttctgc aaaatgagca acgatgtatc aaattgatgc aaatttagat gttgatactt 1928 acaataaagt ttttaatgtg ttttactctt c 1959 <210> 238 <211> 141 <212> PRT <213> Homo sapiens <400> 238 Met Phe Thr Ser Thr Gly Ser Ser Gly Leu Tyr Lys Ala Pro Leu Ser 1 5 10 15 Lys Ser Leu Leu Leu Val Pro Ser Ala Leu Ser Leu Leu Leu Ala Leu 20 25 30 Leu Leu Pro His Cys Gln Lys Leu Phe Val Tyr Asp Leu His Ala Val 35 40 45 Lys Asn Asp Phe Gln Pro Gly Thr Cys Val Cys Ser Val Cys Thr Ile 50 55 60 Leu Leu Leu His Thr Lys Ser Pro Ser Gly Thr Asn Ser Gly Ser Val 65 70 75 80 Val His His Lys Gln Asp Ile Asp Leu Tyr Ile Gly Thr Ala Ala Phe 85 90 95 His Leu Trp Phe Leu His Leu Asp Cys Ser His Lys Trp Thr Tyr Val 100 105 110 Arg Ser Val Leu Arg Gln Gln Asn Val Pro Gly Ala Ser Gly Ala Leu 115 120 125 His Pro Gln Leu Asp Gly Lys Ile Leu Phe Leu Asp Thr 130 135 140 <210> 239 <211> 2112 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (425)..(2077) <400> 239 ggcaaagccc tgtcaccccc aggatccggt catcagggaa agaggacagg gagaccagaa 60 gagggccagc tgggacgagg gggcggacgc ccaggaggca acttctgaga cgcagctcct 120 gagaggggca gggaccaggc gcgggaggcc agagggggca cagagaacaa accccctcag 180 aagtgaagag gagagcggaa ggaaccgaga ggggacggac aggagctgag gaggaaagag 240 gaggggagag gggtcaggcc aggcagccaa ggagaagacg tgtggccggg ggctatcaga 300 aggaaactgg gacggacggg ccgggctcgg gctgtcctgt ggagcagcag catccccggg 360 gccggcagag gcgccagtgg ctgggcggga tgagtctctg agggccactg tggagcgccc 420 cgcc atg gcc ccc cgc acc ctc tgg agc tgc tac ctc tgc tgc ctg ctg 469 Met Ala Pro Arg Thr Leu Trp Ser Cys Tyr Leu Cys Cys Leu Leu 1 5 10 15 acg gca gct gca ggg gcc gcc agc tac cct cct cga ggt ttc agc ctc 517 Thr Ala Ala Ala Gly Ala Ala Ser Tyr Pro Pro Arg Gly Phe Ser Leu 20 25 30 tac aca ggt tcc agt ggg gcc ctc agc ccc ggg ggg ccc cag gcc cag 565 Tyr Thr Gly Ser Ser Gly Ala Leu Ser Pro Gly Gly Pro Gln Ala Gln 35 40 45 att gcc ccc cgg cca gcc agc cgc cac agg aac tgg tgt gcc tac gtg 613 Ile Ala Pro Arg Pro Ala Ser Arg His Arg Asn Trp Cys Ala Tyr Val 50 55 60 gtg acc cgg aca gtg agc tgt gtc ctt gag gat gga gtg gag aca tat 661 Val Thr Arg Thr Val Ser Cys Val Leu Glu Asp Gly Val Glu Thr Tyr 65 70 75 gtc aag tac cag cct tgt gcc tgg ggc cag ccc cag tgt ccc caa agc 709 Val Lys Tyr Gln Pro Cys Ala Trp Gly Gln Pro Gln Cys Pro Gln Ser 80 85 90 95 atc atg tac cgc cgc ttc ctc cgc cct cgc tac cgt gtg gcc tac aag 757 Ile Met Tyr Arg Arg Phe Leu Arg Pro Arg Tyr Arg Val Ala Tyr Lys 100 105 110 aca gtg acc gac atg gag tgg agg tgc tgt cag ggt tat ggg ggc gat 805 Thr Val Thr Asp Met Glu Trp Arg Cys Cys Gln Gly Tyr Gly Gly Asp 115 120 125 gac tgt gct gag agt ccc gct cca gcg ctg ggg cct gcg tct tcc aca 853 Asp Cys Ala Glu Ser Pro Ala Pro Ala Leu Gly Pro Ala Ser Ser Thr 130 135 140 cca cgg ccc ctg gcc cgg cct gcc cgc ccc aac ctc tct ggc tcc agt 901 Pro Arg Pro Leu Ala Arg Pro Ala Arg Pro Asn Leu Ser Gly Ser Ser 145 150 155 gca ggc agc ccc ctc agt gga ctg ggg gga gaa ggt cct ggg gag tca 949 Ala Gly Ser Pro Leu Ser Gly Leu Gly Gly Glu Gly Pro Gly Glu Ser 160 165 170 175 gag aag gtg cag cag ctg gag gaa cag gtg cag agc ctg acc aag gag 997 Glu Lys Val Gln Gln Leu Glu Glu Gln Val Gln Ser Leu Thr Lys Glu 180 185 190 ctg caa ggc ctg cgg ggc gtc ctg caa gga ctg agc ggg cgc ctg gca 1045 Leu Gln Gly Leu Arg Gly Val Leu Gln Gly Leu Ser Gly Arg Leu Ala 195 200 205 gag gat gtg cag agg gct gtg gag acg gcc ttc aac ggg agg cag cag 1093 Glu Asp Val Gln Arg Ala Val Glu Thr Ala Phe Asn Gly Arg Gln Gln 210 215 220 cca gct gac gcg gct gcc cgc cct ggg gtg cat gaa acc ctc aat gag 1141 Pro Ala Asp Ala Ala Ala Arg Pro Gly Val His Glu Thr Leu Asn Glu 225 230 235 atc cag cac cag ctg cag ctc ctg gac acc cgc gtc tcc acc cac gac 1189 Ile Gln His Gln Leu Gln Leu Leu Asp Thr Arg Val Ser Thr His Asp 240 245 250 255 ctg gag ctg ggt cac ctc aac aac cat cat ggc ggc agc agc agc agt 1237 Leu Glu Leu Gly His Leu Asn Asn His His Gly Gly Ser Ser Ser Ser 260 265 270 ggg ggc agc agg gcc cca gcc cca gcc tca gcc cct ccg ggc ccc agt 1285 Gly Gly Ser Arg Ala Pro Ala Pro Ala Ser Ala Pro Pro Gly Pro Ser 275 280 285 gag gag ctg ctg cgg cag ctg gag cag cgg ttg cag gag tcc tgc tcc 1333 Glu Glu Leu Leu Arg Gln Leu Glu Gln Arg Leu Gln Glu Ser Cys Ser 290 295 300 gtg tgc ctg gcc ggg cta gat ggc ttc cgc cgg cag cag cag gag gac 1381 Val Cys Leu Ala Gly Leu Asp Gly Phe Arg Arg Gln Gln Gln Glu Asp 305 310 315 agg gag cgg ctg cga gcg atg gag aag ctg ctg gcc tcg gtg gag gag 1429 Arg Glu Arg Leu Arg Ala Met Glu Lys Leu Leu Ala Ser Val Glu Glu 320 325 330 335 cgg caa cgg cac ctc gca ggg ctg gcg gtg ggc cgc agg ccc cct cag 1477 Arg Gln Arg His Leu Ala Gly Leu Ala Val Gly Arg Arg Pro Pro Gln 340 345 350 gaa tgc tgc tct cca gag ctg ggc cgg cga ctg gca gag ctg gag cgc 1525 Glu Cys Cys Ser Pro Glu Leu Gly Arg Arg Leu Ala Glu Leu Glu Arg 355 360 365 agg ctg gat gtc gtg gcc ggc tca gtg aca gtg ctg agt ggg cgg cga 1573 Arg Leu Asp Val Val Ala Gly Ser Val Thr Val Leu Ser Gly Arg Arg 370 375 380 ggc aca gag ctg gga gga gcc gcg ggg cag gga ggc cac ccc cca ggc 1621 Gly Thr Glu Leu Gly Gly Ala Ala Gly Gln Gly Gly His Pro Pro Gly 385 390 395 tac acc agc ttg gcc tcc cgc ctg tct cgc ctg gag gac cgc ttc aac 1669 Tyr Thr Ser Leu Ala Ser Arg Leu Ser Arg Leu Glu Asp Arg Phe Asn 400 405 410 415 tcc acc ctg ggc cct tcg gag gag cag gag gag agc tgg cct ggg gct 1717 Ser Thr Leu Gly Pro Ser Glu Glu Gln Glu Glu Ser Trp Pro Gly Ala 420 425 430 cct ggg ggg ctg agc cac tgg ctg cct gct gcc cgg ggc cga cta gag 1765 Pro Gly Gly Leu Ser His Trp Leu Pro Ala Ala Arg Gly Arg Leu Glu 435 440 445 cag ttg ggg ggg ctg ctg gcc aat gtg agc ggg gag ctg ggg ggg cgg 1813 Gln Leu Gly Gly Leu Leu Ala Asn Val Ser Gly Glu Leu Gly Gly Arg 450 455 460 ttg gat ctg ttg gag gag cag gtg gca ggg gcc atg cag cgg cac cgc 1861 Leu Asp Leu Leu Glu Glu Gln Val Ala Gly Ala Met Gln Arg His Arg 465 470 475 gcc cag agc ggc ctc tcc cca cgc ccg ggg cgc gcc ggc tca ggg agg 1909 Ala Gln Ser Gly Leu Ser Pro Arg Pro Gly Arg Ala Gly Ser Gly Arg 480 485 490 495 ctc ggg gcc gcc cat gca gac ttt tgg cct ggc gcg atc ccc caa gaa 1957 Leu Gly Ala Ala His Ala Asp Phe Trp Pro Gly Ala Ile Pro Gln Glu 500 505 510 ccc ctc cag ggc cgg cct gcg gag gag ccg atc ctc gca ccc tcc gct 2005 Pro Leu Gln Gly Arg Pro Ala Glu Glu Pro Ile Leu Ala Pro Ser Ala 515 520 525 ccc tcc act ggc cct cca ggt cga ttc cct ggg ctc cag gct ccc ccg 2053 Pro Ser Thr Gly Pro Pro Gly Arg Phe Pro Gly Leu Gln Ala Pro Pro 530 535 540 cgc ggg cgc cgc cca ccg cca tac taaacgatcg aggaataaag acacttggtt 2107 Arg Gly Arg Arg Pro Pro Pro Tyr 545 550 tttct 2112 <210> 240 <211> 551 <212> PRT <213> Homo sapiens <400> 240 Met Ala Pro Arg Thr Leu Trp Ser Cys Tyr Leu Cys Cys Leu Leu Thr 1 5 10 15 Ala Ala Ala Gly Ala Ala Ser Tyr Pro Pro Arg Gly Phe Ser Leu Tyr 20 25 30 Thr Gly Ser Ser Gly Ala Leu Ser Pro Gly Gly Pro Gln Ala Gln Ile 35 40 45 Ala Pro Arg Pro Ala Ser Arg His Arg Asn Trp Cys Ala Tyr Val Val 50 55 60 Thr Arg Thr Val Ser Cys Val Leu Glu Asp Gly Val Glu Thr Tyr Val 65 70 75 80 Lys Tyr Gln Pro Cys Ala Trp Gly Gln Pro Gln Cys Pro Gln Ser Ile 85 90 95 Met Tyr Arg Arg Phe Leu Arg Pro Arg Tyr Arg Val Ala Tyr Lys Thr 100 105 110 Val Thr Asp Met Glu Trp Arg Cys Cys Gln Gly Tyr Gly Gly Asp Asp 115 120 125 Cys Ala Glu Ser Pro Ala Pro Ala Leu Gly Pro Ala Ser Ser Thr Pro 130 135 140 Arg Pro Leu Ala Arg Pro Ala Arg Pro Asn Leu Ser Gly Ser Ser Ala 145 150 155 160 Gly Ser Pro Leu Ser Gly Leu Gly Gly Glu Gly Pro Gly Glu Ser Glu 165 170 175 Lys Val Gln Gln Leu Glu Glu Gln Val Gln Ser Leu Thr Lys Glu Leu 180 185 190 Gln Gly Leu Arg Gly Val Leu Gln Gly Leu Ser Gly Arg Leu Ala Glu 195 200 205 Asp Val Gln Arg Ala Val Glu Thr Ala Phe Asn Gly Arg Gln Gln Pro 210 215 220 Ala Asp Ala Ala Ala Arg Pro Gly Val His Glu Thr Leu Asn Glu Ile 225 230 235 240 Gln His Gln Leu Gln Leu Leu Asp Thr Arg Val Ser Thr His Asp Leu 245 250 255 Glu Leu Gly His Leu Asn Asn His His Gly Gly Ser Ser Ser Ser Gly 260 265 270 Gly Ser Arg Ala Pro Ala Pro Ala Ser Ala Pro Pro Gly Pro Ser Glu 275 280 285 Glu Leu Leu Arg Gln Leu Glu Gln Arg Leu Gln Glu Ser Cys Ser Val 290 295 300 Cys Leu Ala Gly Leu Asp Gly Phe Arg Arg Gln Gln Gln Glu Asp Arg 305 310 315 320 Glu Arg Leu Arg Ala Met Glu Lys Leu Leu Ala Ser Val Glu Glu Arg 325 330 335 Gln Arg His Leu Ala Gly Leu Ala Val Gly Arg Arg Pro Pro Gln Glu 340 345 350 Cys Cys Ser Pro Glu Leu Gly Arg Arg Leu Ala Glu Leu Glu Arg Arg 355 360 365 Leu Asp Val Val Ala Gly Ser Val Thr Val Leu Ser Gly Arg Arg Gly 370 375 380 Thr Glu Leu Gly Gly Ala Ala Gly Gln Gly Gly His Pro Pro Gly Tyr 385 390 395 400 Thr Ser Leu Ala Ser Arg Leu Ser Arg Leu Glu Asp Arg Phe Asn Ser 405 410 415 Thr Leu Gly Pro Ser Glu Glu Gln Glu Glu Ser Trp Pro Gly Ala Pro 420 425 430 Gly Gly Leu Ser His Trp Leu Pro Ala Ala Arg Gly Arg Leu Glu Gln 435 440 445 Leu Gly Gly Leu Leu Ala Asn Val Ser Gly Glu Leu Gly Gly Arg Leu 450 455 460 Asp Leu Leu Glu Glu Gln Val Ala Gly Ala Met Gln Arg His Arg Ala 465 470 475 480 Gln Ser Gly Leu Ser Pro Arg Pro Gly Arg Ala Gly Ser Gly Arg Leu 485 490 495 Gly Ala Ala His Ala Asp Phe Trp Pro Gly Ala Ile Pro Gln Glu Pro 500 505 510 Leu Gln Gly Arg Pro Ala Glu Glu Pro Ile Leu Ala Pro Ser Ala Pro 515 520 525 Ser Thr Gly Pro Pro Gly Arg Phe Pro Gly Leu Gln Ala Pro Pro Arg 530 535 540 Gly Arg Arg Pro Pro Pro Tyr 545 550 <210> 241 <211> 1765 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (440)..(1669) <400> 241 aaattggagg tcccgggagc gaagtccagc tgccgttagg cgctgggata gtcgcacgct 60 ggatgcatct acgtccgccg agcccctggg gcgaagaggc cgcgtccgcc ttcagttgtg 120 gccggtgctt cgccccctga cccttcgccc ccaaagacca gctctaacgt gagcgcctcg 180 gccgccctgc cccagcctcg tacacgccgc cagcctcgcc cagccggtgt ccggagaccc 240 tcgggccgtg tccatttgtg ggcaaagcca gcggggcagg cttggccaga gtgcaccact 300 cggcgccgtc ccaggcccga cgctctgggc gcgcccggaa ccccaggttc gcggcccgtg 360 tttccgaccg gcggaggggg ctcagcggcc cgatcccacg gaagcgcgct cggaggggtg 420 ggacccggcc ggaccggag atg gcg ccg cca gcg ggc ggg gcg gcg gcg gcg 472 Met Ala Pro Pro Ala Gly Gly Ala Ala Ala Ala 1 5 10 gcc tcg gac ttg ggc tcc gcc gca gtg ctc ttg gct gtg cac gcc gcg 520 Ala Ser Asp Leu Gly Ser Ala Ala Val Leu Leu Ala Val His Ala Ala 15 20 25 gtg agg ccg ctg ggc gcc ggg cca gac gcc gag gca cag ctg cgg agg 568 Val Arg Pro Leu Gly Ala Gly Pro Asp Ala Glu Ala Gln Leu Arg Arg 30 35 40 ctg cag ctg agc gcg gac cct gag agg cct ggg cgc ttc cgg ctg gag 616 Leu Gln Leu Ser Ala Asp Pro Glu Arg Pro Gly Arg Phe Arg Leu Glu 45 50 55 ctg ctg ggc gcg gga cct ggg gcg gtt aat ttg gag tgg ccc ctg gag 664 Leu Leu Gly Ala Gly Pro Gly Ala Val Asn Leu Glu Trp Pro Leu Glu 60 65 70 75 tca gtt tcc tac acc atc cga ggc ccc acc cag cac gag cta cag cct 712 Ser Val Ser Tyr Thr Ile Arg Gly Pro Thr Gln His Glu Leu Gln Pro 80 85 90 cca cca gga ggg cct gga acc ctc agc ctg cac ttc ctc aac cct cag 760 Pro Pro Gly Gly Pro Gly Thr Leu Ser Leu His Phe Leu Asn Pro Gln 95 100 105 gaa gct cag cgg tgg gca gtc cta gtc cga ggt gcc acc gtg gaa gga 808 Glu Ala Gln Arg Trp Ala Val Leu Val Arg Gly Ala Thr Val Glu Gly 110 115 120 cag aat ggc agc aag agc aac tca cca cca gcc ttg ggc cca gaa gca 856 Gln Asn Gly Ser Lys Ser Asn Ser Pro Pro Ala Leu Gly Pro Glu Ala 125 130 135 tgc cct gtc tcc ctg ccc agt ccc ccg gaa gcc tcc aca ctc aag ggc 904 Cys Pro Val Ser Leu Pro Ser Pro Pro Glu Ala Ser Thr Leu Lys Gly 140 145 150 155 cct cca cct gag gca gat ctt cct agg agc cct gga aac ttg acg gag 952 Pro Pro Pro Glu Ala Asp Leu Pro Arg Ser Pro Gly Asn Leu Thr Glu 160 165 170 aga gaa gag ctg gca ggg agc ctg gcc cgg gct att gca ggt gga gac 1000 Arg Glu Glu Leu Ala Gly Ser Leu Ala Arg Ala Ile Ala Gly Gly Asp 175 180 185 gag aag ggg gca gcc caa gtg gca gcc gtc ctg gcc cag cat cgt gtg 1048 Glu Lys Gly Ala Ala Gln Val Ala Ala Val Leu Ala Gln His Arg Val 190 195 200 gcc ctg agt gtt cag ctt cag gag gcc tgc ttc cca cct ggc ccc atc 1096 Ala Leu Ser Val Gln Leu Gln Glu Ala Cys Phe Pro Pro Gly Pro Ile 205 210 215 agg ctg cag gtc aca ctt gaa gac gct gcc tct gcc gca tcc gcc gcg 1144 Arg Leu Gln Val Thr Leu Glu Asp Ala Ala Ser Ala Ala Ser Ala Ala 220 225 230 235 tcc tct gca cac gtt gcc ctg cgg gtc cac ccc cac tgc act gtt gca 1192 Ser Ser Ala His Val Ala Leu Arg Val His Pro His Cys Thr Val Ala 240 245 250 gct ctc cag gag cag gtg ttc tca gag ctc ggt ttc ccg cca gcc gtg 1240 Ala Leu Gln Glu Gln Val Phe Ser Glu Leu Gly Phe Pro Pro Ala Val 255 260 265 caa cgc tgg gtc atc gga cgg tgc ctg tgt gtg cct gag cgc agc ctt 1288 Gln Arg Trp Val Ile Gly Arg Cys Leu Cys Val Pro Glu Arg Ser Leu 270 275 280 gcc tct tac ggg gtt cgg cag gat ggg gac cct gct ttc ctc tac ttg 1336 Ala Ser Tyr Gly Val Arg Gln Asp Gly Asp Pro Ala Phe Leu Tyr Leu 285 290 295 ctg tca gct cct cga gaa gcc cca gcc aca gga cct agc cct cag cac 1384 Leu Ser Ala Pro Arg Glu Ala Pro Ala Thr Gly Pro Ser Pro Gln His 300 305 310 315 ccc cag aag atg gac ggg gaa ctt gga cgc ttg ttt ccc cca tca ttg 1432 Pro Gln Lys Met Asp Gly Glu Leu Gly Arg Leu Phe Pro Pro Ser Leu 320 325 330 ggg cta ccc cag gcc ccc agc cag ctg cct cca gcc tgc cca gtc cac 1480 Gly Leu Pro Gln Ala Pro Ser Gln Leu Pro Pro Ala Cys Pro Val His 335 340 345 tcc agc cca gct ggt cct gtc ctt cct gca cct tca tca atg ccc cag 1528 Ser Ser Pro Ala Gly Pro Val Leu Pro Ala Pro Ser Ser Met Pro Gln 350 355 360 acc gcc ctg gct gtg aga tgt gta gca ccc aga ggc cct gca ctt ggg 1576 Thr Ala Leu Ala Val Arg Cys Val Ala Pro Arg Gly Pro Ala Leu Gly 365 370 375 acc ccc ttg ctg cag ctt cca cct agc agc cac cag agg tta caa ggg 1624 Thr Pro Leu Leu Gln Leu Pro Pro Ser Ser His Gln Arg Leu Gln Gly 380 385 390 395 gag agt ggc cct tcc ctc aca agt ccg aca tct cca ggc ccc cac 1669 Glu Ser Gly Pro Ser Leu Thr Ser Pro Thr Ser Pro Gly Pro His 400 405 410 tgaactccgg ggacctctac tgactgcttg ctgggacagt caccagggtt ggggggaagg 1729 gccacaaaat gaaaccatta aagaccctta agagcc 1765 <210> 242 <211> 410 <212> PRT <213> Homo sapiens <400> 242 Met Ala Pro Pro Ala Gly Gly Ala Ala Ala Ala Ala Ser Asp Leu Gly 1 5 10 15 Ser Ala Ala Val Leu Leu Ala Val His Ala Ala Val Arg Pro Leu Gly 20 25 30 Ala Gly Pro Asp Ala Glu Ala Gln Leu Arg Arg Leu Gln Leu Ser Ala 35 40 45 Asp Pro Glu Arg Pro Gly Arg Phe Arg Leu Glu Leu Leu Gly Ala Gly 50 55 60 Pro Gly Ala Val Asn Leu Glu Trp Pro Leu Glu Ser Val Ser Tyr Thr 65 70 75 80 Ile Arg Gly Pro Thr Gln His Glu Leu Gln Pro Pro Pro Gly Gly Pro 85 90 95 Gly Thr Leu Ser Leu His Phe Leu Asn Pro Gln Glu Ala Gln Arg Trp 100 105 110 Ala Val Leu Val Arg Gly Ala Thr Val Glu Gly Gln Asn Gly Ser Lys 115 120 125 Ser Asn Ser Pro Pro Ala Leu Gly Pro Glu Ala Cys Pro Val Ser Leu 130 135 140 Pro Ser Pro Pro Glu Ala Ser Thr Leu Lys Gly Pro Pro Pro Glu Ala 145 150 155 160 Asp Leu Pro Arg Ser Pro Gly Asn Leu Thr Glu Arg Glu Glu Leu Ala 165 170 175 Gly Ser Leu Ala Arg Ala Ile Ala Gly Gly Asp Glu Lys Gly Ala Ala 180 185 190 Gln Val Ala Ala Val Leu Ala Gln His Arg Val Ala Leu Ser Val Gln 195 200 205 Leu Gln Glu Ala Cys Phe Pro Pro Gly Pro Ile Arg Leu Gln Val Thr 210 215 220 Leu Glu Asp Ala Ala Ser Ala Ala Ser Ala Ala Ser Ser Ala His Val 225 230 235 240 Ala Leu Arg Val His Pro His Cys Thr Val Ala Ala Leu Gln Glu Gln 245 250 255 Val Phe Ser Glu Leu Gly Phe Pro Pro Ala Val Gln Arg Trp Val Ile 260 265 270 Gly Arg Cys Leu Cys Val Pro Glu Arg Ser Leu Ala Ser Tyr Gly Val 275 280 285 Arg Gln Asp Gly Asp Pro Ala Phe Leu Tyr Leu Leu Ser Ala Pro Arg 290 295 300 Glu Ala Pro Ala Thr Gly Pro Ser Pro Gln His Pro Gln Lys Met Asp 305 310 315 320 Gly Glu Leu Gly Arg Leu Phe Pro Pro Ser Leu Gly Leu Pro Gln Ala 325 330 335 Pro Ser Gln Leu Pro Pro Ala Cys Pro Val His Ser Ser Pro Ala Gly 340 345 350 Pro Val Leu Pro Ala Pro Ser Ser Met Pro Gln Thr Ala Leu Ala Val 355 360 365 Arg Cys Val Ala Pro Arg Gly Pro Ala Leu Gly Thr Pro Leu Leu Gln 370 375 380 Leu Pro Pro Ser Ser His Gln Arg Leu Gln Gly Glu Ser Gly Pro Ser 385 390 395 400 Leu Thr Ser Pro Thr Ser Pro Gly Pro His 405 410 <210> 243 <211> 1369 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (23)..(748) <400> 243 aacgagctcg ggcctcaccc gg atg gcg gct gcg acg cgc ggc tgc cgg ccc 52 Met Ala Ala Ala Thr Arg Gly Cys Arg Pro 1 5 10 tgg ggc tcg ctc ctc ggg ctg ctc ggg ctg gtc tcg gcc gcg gcc gcc 100 Trp Gly Ser Leu Leu Gly Leu Leu Gly Leu Val Ser Ala Ala Ala Ala 15 20 25 gcc tgg gac ctg gct tcc ctg cgc tgc acc ttg ggc gcc ttt tgc gaa 148 Ala Trp Asp Leu Ala Ser Leu Arg Cys Thr Leu Gly Ala Phe Cys Glu 30 35 40 tgc gac ttc cgg ccc gac ttg ccg ggt ctg gag tgt gac ctg gct cag 196 Cys Asp Phe Arg Pro Asp Leu Pro Gly Leu Glu Cys Asp Leu Ala Gln 45 50 55 cac ctg gcc ggc cag cat ctg gcc aag gcg ctg gtg gtg aag gcg ctg 244 His Leu Ala Gly Gln His Leu Ala Lys Ala Leu Val Val Lys Ala Leu 60 65 70 aag gcc ttt gtg cgg gac cca gcc ccc acc aag ccg ctg gtc ctc tcc 292 Lys Ala Phe Val Arg Asp Pro Ala Pro Thr Lys Pro Leu Val Leu Ser 75 80 85 90 ctg cac ggc tgg acc ggc acc ggc aaa tcc tat gtc agc tcc ctg ctg 340 Leu His Gly Trp Thr Gly Thr Gly Lys Ser Tyr Val Ser Ser Leu Leu 95 100 105 gcg cac tac ctc ttc cag ggc ggc ctc cgc agc ccc cgc gtg cac cac 388 Ala His Tyr Leu Phe Gln Gly Gly Leu Arg Ser Pro Arg Val His His 110 115 120 ttt tct ccc gtc ctc cac ttc ccc cac ccc agc cac atc gag cgc tac 436 Phe Ser Pro Val Leu His Phe Pro His Pro Ser His Ile Glu Arg Tyr 125 130 135 aag aag gat ctg aag agc tgg gtc caa ggg aac ctc act gcc tgt ggc 484 Lys Lys Asp Leu Lys Ser Trp Val Gln Gly Asn Leu Thr Ala Cys Gly 140 145 150 cgc tcc ctc ttc ctc ttc gat gag atg gac aag atg ccc cca ggc ctg 532 Arg Ser Leu Phe Leu Phe Asp Glu Met Asp Lys Met Pro Pro Gly Leu 155 160 165 170 atg gaa gtc ctg cgg cct ttc ctg ggc tcc tcc tgg gtg gta tac ggg 580 Met Glu Val Leu Arg Pro Phe Leu Gly Ser Ser Trp Val Val Tyr Gly 175 180 185 acc aat tac cgc aaa gcc atc ttc atc ttc atc aga tgg ctt ctc aaa 628 Thr Asn Tyr Arg Lys Ala Ile Phe Ile Phe Ile Arg Trp Leu Leu Lys 190 195 200 ctc ggg cat cat gga aga gcg cct cct aga cgc agt ggt gcc ctt cct 676 Leu Gly His His Gly Arg Ala Pro Pro Arg Arg Ser Gly Ala Leu Pro 205 210 215 ccc gct cca gcg gca cca cgt ccg gca ctg cgt gct caa cga gct ggc 724 Pro Ala Pro Ala Ala Pro Arg Pro Ala Leu Arg Ala Gln Arg Ala Gly 220 225 230 cca gct ggg cct gga gcc aag gga tgaggttgtc caggctgtgc tggacagcac 778 Pro Ala Gly Pro Gly Ala Lys Gly 235 240 caccttcttc cctgaagacg agcagctctt ctcctccaac ggctgcaaga ccgtggcctc 838 ccgaatcgcc ttcttcctct gactctctga gtggtgtcct cggcccccct gatggccagg 898 ccatgcagga aaggccaggg gcctctgtca caggaaccca gagcaccaag tgagatgaac 958 ggagtgtcgg ctaggccacg ggacagatgg ccaggaaggg ccctggcctc taaactggct 1018 cgagagcatc ttggccccgg ccaccttccc cagggaaacc cctggtcacc ccagaacctc 1078 actgagcctt gacctccccc tgcagcctga gccttcttac tgtgaattat aactcaggga 1138 ctgtggctcg tggcggtgct ccctcctcag tctgccaccc ttgccccttg cctccttggt 1198 cgggcaccat acctcctccc ctccacccca caccctgtgt ccatatcaag ccaggtggag 1258 ccttctcagt ttccagaaat ggagggactc aagctgccac ttgggcctgg ttttagatgt 1318 ttttaatttt gtaaaagaaa acaagtataa taaactcagc tgtgggacca g 1369 <210> 244 <211> 242 <212> PRT <213> Homo sapiens <400> 244 Met Ala Ala Ala Thr Arg Gly Cys Arg Pro Trp Gly Ser Leu Leu Gly 1 5 10 15 Leu Leu Gly Leu Val Ser Ala Ala Ala Ala Ala Trp Asp Leu Ala Ser 20 25 30 Leu Arg Cys Thr Leu Gly Ala Phe Cys Glu Cys Asp Phe Arg Pro Asp 35 40 45 Leu Pro Gly Leu Glu Cys Asp Leu Ala Gln His Leu Ala Gly Gln His 50 55 60 Leu Ala Lys Ala Leu Val Val Lys Ala Leu Lys Ala Phe Val Arg Asp 65 70 75 80 Pro Ala Pro Thr Lys Pro Leu Val Leu Ser Leu His Gly Trp Thr Gly 85 90 95 Thr Gly Lys Ser Tyr Val Ser Ser Leu Leu Ala His Tyr Leu Phe Gln 100 105 110 Gly Gly Leu Arg Ser Pro Arg Val His His Phe Ser Pro Val Leu His 115 120 125 Phe Pro His Pro Ser His Ile Glu Arg Tyr Lys Lys Asp Leu Lys Ser 130 135 140 Trp Val Gln Gly Asn Leu Thr Ala Cys Gly Arg Ser Leu Phe Leu Phe 145 150 155 160 Asp Glu Met Asp Lys Met Pro Pro Gly Leu Met Glu Val Leu Arg Pro 165 170 175 Phe Leu Gly Ser Ser Trp Val Val Tyr Gly Thr Asn Tyr Arg Lys Ala 180 185 190 Ile Phe Ile Phe Ile Arg Trp Leu Leu Lys Leu Gly His His Gly Arg 195 200 205 Ala Pro Pro Arg Arg Ser Gly Ala Leu Pro Pro Ala Pro Ala Ala Pro 210 215 220 Arg Pro Ala Leu Arg Ala Gln Arg Ala Gly Pro Ala Gly Pro Gly Ala 225 230 235 240 Lys Gly <210> 245 <211> 1584 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (100)..(1194) <400> 245 gcgctcgccg cgctcgcact gaagcccggg ccctcgcgcg ccgcggttcg ccccgcagcc 60 tcgccccctg cccacccggg cggccgtagg gcggtcacg atg ctg ccg ccc tta 114 Met Leu Pro Pro Leu 1 5 ccc tcc cgc ctc ggg ctg ctg ctg ctg ctg ctc ctg tgc ccg gcg cac 162 Pro Ser Arg Leu Gly Leu Leu Leu Leu Leu Leu Leu Cys Pro Ala His 10 15 20 gtc ggc gga ctg tgg tgg gct gtg ggc agc ccc ttg gtt atg gac cct 210 Val Gly Gly Leu Trp Trp Ala Val Gly Ser Pro Leu Val Met Asp Pro 25 30 35 acc agc atc tgc agg aag gca cgg cgg ctg gcc ggg cgg cag gcc gag 258 Thr Ser Ile Cys Arg Lys Ala Arg Arg Leu Ala Gly Arg Gln Ala Glu 40 45 50 ttg tgc cag gct gag ccg gaa gtg gtg gca gag cta gct cgg ggc gcc 306 Leu Cys Gln Ala Glu Pro Glu Val Val Ala Glu Leu Ala Arg Gly Ala 55 60 65 cgg ctc ggg gtg cga gag tgc cag ttc cag ttc cgc ttc cgc cgc tgg 354 Arg Leu Gly Val Arg Glu Cys Gln Phe Gln Phe Arg Phe Arg Arg Trp 70 75 80 85 aat tgc tcc agc cac agc aag gcc ttt gga cgc atc ctg caa cag gac 402 Asn Cys Ser Ser His Ser Lys Ala Phe Gly Arg Ile Leu Gln Gln Asp 90 95 100 att cgg gag acg gcc ttc gtg ttc gcc atc act gcg gcc ggc gcc agc 450 Ile Arg Glu Thr Ala Phe Val Phe Ala Ile Thr Ala Ala Gly Ala Ser 105 110 115 cac gcc gtc acg cag gcc tgt tct atg ggc gag ctg ctg cag tgc ggc 498 His Ala Val Thr Gln Ala Cys Ser Met Gly Glu Leu Leu Gln Cys Gly 120 125 130 tgc cag gcg ccc cgc tgg cgg gcc cct ccc cgg ccc tcc ggc ctg ccc 546 Cys Gln Ala Pro Arg Trp Arg Ala Pro Pro Arg Pro Ser Gly Leu Pro 135 140 145 ggc acc ccc gga ccc cct ggc ccc gcg ggc tcc ccg gaa ggc agc gcc 594 Gly Thr Pro Gly Pro Pro Gly Pro Ala Gly Ser Pro Glu Gly Ser Ala 150 155 160 165 gcc tgg gag tgg gga ggc tgc ggc gac gac gtg gac ttc ggg gac gag 642 Ala Trp Glu Trp Gly Gly Cys Gly Asp Asp Val Asp Phe Gly Asp Glu 170 175 180 aag tcg agg ctc ttt atg gac gcg cgg cac aag cgg gga cgc gga gac 690 Lys Ser Arg Leu Phe Met Asp Ala Arg His Lys Arg Gly Arg Gly Asp 185 190 195 atc cgc gcg ttg gtg caa ctg cac aac aac gag gcg ggc agg ctg gcc 738 Ile Arg Ala Leu Val Gln Leu His Asn Asn Glu Ala Gly Arg Leu Ala 200 205 210 gtg cgg agc cac acg cgc acc gag tgc aaa tgc cac ggg ctg tcg gga 786 Val Arg Ser His Thr Arg Thr Glu Cys Lys Cys His Gly Leu Ser Gly 215 220 225 tca tgc gcg ctg cgc acc tgc tgg cag aag ctg cct cca ttt cgc gag 834 Ser Cys Ala Leu Arg Thr Cys Trp Gln Lys Leu Pro Pro Phe Arg Glu 230 235 240 245 gtg ggc gcg cgg ctg ctg gag cgc ttc cac ggc gcc tca cgc gtc atg 882 Val Gly Ala Arg Leu Leu Glu Arg Phe His Gly Ala Ser Arg Val Met 250 255 260 ggc acc aac gac ggc aag gcc ctg ctg ccc gcc gtc cgc acg ctc aag 930 Gly Thr Asn Asp Gly Lys Ala Leu Leu Pro Ala Val Arg Thr Leu Lys 265 270 275 ccg ccg ggc cga gcg gac ctc ctc tac gcc gcc gat tcg ccc gac ttc 978 Pro Pro Gly Arg Ala Asp Leu Leu Tyr Ala Ala Asp Ser Pro Asp Phe 280 285 290 tgc gcc ccc aac cga cgc acc ggc tcc ccc ggc acg cgc ggt cgc gcc 1026 Cys Ala Pro Asn Arg Arg Thr Gly Ser Pro Gly Thr Arg Gly Arg Ala 295 300 305 tgc aat agc agc gcc ccg gac ctc agc ggc tgc gac ctg ctg tgc tgc 1074 Cys Asn Ser Ser Ala Pro Asp Leu Ser Gly Cys Asp Leu Leu Cys Cys 310 315 320 325 ggc cgc ggg cac cgc cag gag agc gtg cag ctc gaa gag aac tgc ctg 1122 Gly Arg Gly His Arg Gln Glu Ser Val Gln Leu Glu Glu Asn Cys Leu 330 335 340 tgc cgc ttc cac tgg tgc tgc gta gta cag tgc cac cgc tgc cgt gtg 1170 Cys Arg Phe His Trp Cys Cys Val Val Gln Cys His Arg Cys Arg Val 345 350 355 cgc aag gag ctc agc ctc tgc ctg tgacccgccg cccggccgct agactgactt 1224 Arg Lys Glu Leu Ser Leu Cys Leu 360 365 cgcgcagcgg tggctcgcac ctgtgggacc tcagggcacc ggcaccgggc gcctctcgcc 1284 gctcgagccc agcctctccc tgccaaagcc caactcccag ggctctggaa atggtgaggc 1344 gaggggcttg agaggaacgc ccacccacga aggcccaggg cgccagacgg ccccgaaaag 1404 gcgctcgggg agcgtttaaa ggacactgta caggccctcc ctccccttgg cctctaggag 1464 gaaacagttt tttagactgg aaaaaagcca gtctaaaggc ctctggatac tgggctcccc 1524 agaactgctg gccacaggat ggtgggtgag gttagtatca ataaagatat ttaaaccacc 1584 <210> 246 <211> 365 <212> PRT <213> Homo sapiens <400> 246 Met Leu Pro Pro Leu Pro Ser Arg Leu Gly Leu Leu Leu Leu Leu Leu 1 5 10 15 Leu Cys Pro Ala His Val Gly Gly Leu Trp Trp Ala Val Gly Ser Pro 20 25 30 Leu Val Met Asp Pro Thr Ser Ile Cys Arg Lys Ala Arg Arg Leu Ala 35 40 45 Gly Arg Gln Ala Glu Leu Cys Gln Ala Glu Pro Glu Val Val Ala Glu 50 55 60 Leu Ala Arg Gly Ala Arg Leu Gly Val Arg Glu Cys Gln Phe Gln Phe 65 70 75 80 Arg Phe Arg Arg Trp Asn Cys Ser Ser His Ser Lys Ala Phe Gly Arg 85 90 95 Ile Leu Gln Gln Asp Ile Arg Glu Thr Ala Phe Val Phe Ala Ile Thr 100 105 110 Ala Ala Gly Ala Ser His Ala Val Thr Gln Ala Cys Ser Met Gly Glu 115 120 125 Leu Leu Gln Cys Gly Cys Gln Ala Pro Arg Trp Arg Ala Pro Pro Arg 130 135 140 Pro Ser Gly Leu Pro Gly Thr Pro Gly Pro Pro Gly Pro Ala Gly Ser 145 150 155 160 Pro Glu Gly Ser Ala Ala Trp Glu Trp Gly Gly Cys Gly Asp Asp Val 165 170 175 Asp Phe Gly Asp Glu Lys Ser Arg Leu Phe Met Asp Ala Arg His Lys 180 185 190 Arg Gly Arg Gly Asp Ile Arg Ala Leu Val Gln Leu His Asn Asn Glu 195 200 205 Ala Gly Arg Leu Ala Val Arg Ser His Thr Arg Thr Glu Cys Lys Cys 210 215 220 His Gly Leu Ser Gly Ser Cys Ala Leu Arg Thr Cys Trp Gln Lys Leu 225 230 235 240 Pro Pro Phe Arg Glu Val Gly Ala Arg Leu Leu Glu Arg Phe His Gly 245 250 255 Ala Ser Arg Val Met Gly Thr Asn Asp Gly Lys Ala Leu Leu Pro Ala 260 265 270 Val Arg Thr Leu Lys Pro Pro Gly Arg Ala Asp Leu Leu Tyr Ala Ala 275 280 285 Asp Ser Pro Asp Phe Cys Ala Pro Asn Arg Arg Thr Gly Ser Pro Gly 290 295 300 Thr Arg Gly Arg Ala Cys Asn Ser Ser Ala Pro Asp Leu Ser Gly Cys 305 310 315 320 Asp Leu Leu Cys Cys Gly Arg Gly His Arg Gln Glu Ser Val Gln Leu 325 330 335 Glu Glu Asn Cys Leu Cys Arg Phe His Trp Cys Cys Val Val Gln Cys 340 345 350 His Arg Cys Arg Val Arg Lys Glu Leu Ser Leu Cys Leu 355 360 365 <210> 247 <211> 899 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (77)..(493) <400> 247 gtgcgcgttg gggcggccgg ccaatgccgg accgcttcgg caccgcccgc ccgatccctc 60 cacccgtggg ccggca atg gcg ggc gca gtt tcg ctc ttg ggt gtg gtg ggg 112 Met Ala Gly Ala Val Ser Leu Leu Gly Val Val Gly 1 5 10 ctg ctg ctt gtg tct gcg ctg tcc ggg gtc cta gga gac cgc gcc aat 160 Leu Leu Leu Val Ser Ala Leu Ser Gly Val Leu Gly Asp Arg Ala Asn 15 20 25 ccc gac ctc cgg gca cac cca ggg aac gca gcc cac ccc ggc tct gga 208 Pro Asp Leu Arg Ala His Pro Gly Asn Ala Ala His Pro Gly Ser Gly 30 35 40 gcc acg gaa ccc cgg cgg cga cca ccg ctc aag gat caa cgc gag cgg 256 Ala Thr Glu Pro Arg Arg Arg Pro Pro Leu Lys Asp Gln Arg Glu Arg 45 50 55 60 acc cgg gcc ggg tcg ctg cct ctg ggg gcg ctg tac acc gcg gcc gtc 304 Thr Arg Ala Gly Ser Leu Pro Leu Gly Ala Leu Tyr Thr Ala Ala Val 65 70 75 gcg gct ttt gtg ctg tac aag tgt ttg cag ggg aaa gat gaa act gcg 352 Ala Ala Phe Val Leu Tyr Lys Cys Leu Gln Gly Lys Asp Glu Thr Ala 80 85 90 gtt ctc cac gag gag gca agc aag cag cag cca ctg cag tca gag caa 400 Val Leu His Glu Glu Ala Ser Lys Gln Gln Pro Leu Gln Ser Glu Gln 95 100 105 cag ctg gcc cag ttg aca caa cag ctg gcc cag aca gag cag cac ctg 448 Gln Leu Ala Gln Leu Thr Gln Gln Leu Ala Gln Thr Glu Gln His Leu 110 115 120 aac aac ctg atg gcc cag ctg gac ccc ctt ttt gag cgg agc ttc 493 Asn Asn Leu Met Ala Gln Leu Asp Pro Leu Phe Glu Arg Ser Phe 125 130 135 tgaacatgaa gctatggacc atccacgagc tgctgcaaga tagcaagccg gacaaggata 553 tggaggcttc agaaccaggt gaaggctcgg gaggcgagtc tgctggaggt ggagacaaag 613 tctctgaaac tggaacattc ctgatctctc cccacacaga ggccagcaga cctcttcctg 673 aggacttctg tttaaaggag gacgaggagg aggttggtga cagtcaggcc tgggaggagc 733 ccacaaactg gagcacagag acatggaacc tagctacttc ctgggaggtg gggcggggac 793 tacggagaag gtgcagccag gctgtggcaa agggccccag tcacagcctt ggctgggaag 853 gagggacgac agctgaaggt cgactaaaac aaagtctgtt ttcatg 899 <210> 248 <211> 139 <212> PRT <213> Homo sapiens <400> 248 Met Ala Gly Ala Val Ser Leu Leu Gly Val Val Gly Leu Leu Leu Val 1 5 10 15 Ser Ala Leu Ser Gly Val Leu Gly Asp Arg Ala Asn Pro Asp Leu Arg 20 25 30 Ala His Pro Gly Asn Ala Ala His Pro Gly Ser Gly Ala Thr Glu Pro 35 40 45 Arg Arg Arg Pro Pro Leu Lys Asp Gln Arg Glu Arg Thr Arg Ala Gly 50 55 60 Ser Leu Pro Leu Gly Ala Leu Tyr Thr Ala Ala Val Ala Ala Phe Val 65 70 75 80 Leu Tyr Lys Cys Leu Gln Gly Lys Asp Glu Thr Ala Val Leu His Glu 85 90 95 Glu Ala Ser Lys Gln Gln Pro Leu Gln Ser Glu Gln Gln Leu Ala Gln 100 105 110 Leu Thr Gln Gln Leu Ala Gln Thr Glu Gln His Leu Asn Asn Leu Met 115 120 125 Ala Gln Leu Asp Pro Leu Phe Glu Arg Ser Phe 130 135 <210> 249 <211> 1874 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (156)..(818) <400> 249 agcctgagaa gagcgtctcg cccgggagcg gcggcggcca tcgagaccca cccaaggcgc 60 gtccccctcg gcctcccagc gctcccaagc cgcagcggcc gcgccccttc agctagctcg 120 ctcgctcgct ctgcttccct gctgccggct gcgcc atg gcg ttg gcg ttg gcg 173 Met Ala Leu Ala Leu Ala 1 5 gcg ctg gcg gcg gtc gag ccg gcc tgc ggc agc cgg tac tgg cag ttg 221 Ala Leu Ala Ala Val Glu Pro Ala Cys Gly Ser Arg Tyr Trp Gln Leu 10 15 20 cag aat gaa gaa gag tct gga gaa cct gaa cag gct gca ggt gat gct 269 Gln Asn Glu Glu Glu Ser Gly Glu Pro Glu Gln Ala Ala Gly Asp Ala 25 30 35 cct cca cct tac agc agc att tct gca gag agc gca gca tat ttt gac 317 Pro Pro Pro Tyr Ser Ser Ile Ser Ala Glu Ser Ala Ala Tyr Phe Asp 40 45 50 tac aag gat gag tct ggg ttt cca aag ccc cca tct tac aat gta gct 365 Tyr Lys Asp Glu Ser Gly Phe Pro Lys Pro Pro Ser Tyr Asn Val Ala 55 60 65 70 aca aca ctg ccc agt tat gat gaa gcg gag agg acc aag gct gaa gct 413 Thr Thr Leu Pro Ser Tyr Asp Glu Ala Glu Arg Thr Lys Ala Glu Ala 75 80 85 act atc cct ttg gtt cct ggg aga gat gag gat ttt gtg ggt cgg gat 461 Thr Ile Pro Leu Val Pro Gly Arg Asp Glu Asp Phe Val Gly Arg Asp 90 95 100 gat ctt gat gat gct gac cag ctg agg ata gga aat gat ggg att ttc 509 Asp Leu Asp Asp Ala Asp Gln Leu Arg Ile Gly Asn Asp Gly Ile Phe 105 110 115 atg tta act ttt ttc atg gca ttc ctc ttt aac tgg att ggg ttt ttc 557 Met Leu Thr Phe Phe Met Ala Phe Leu Phe Asn Trp Ile Gly Phe Phe 120 125 130 ctg tct ttt tgc ctg acc act tca gct gca gga agg tat ggg gcc att 605 Leu Ser Phe Cys Leu Thr Thr Ser Ala Ala Gly Arg Tyr Gly Ala Ile 135 140 145 150 tca gga ttt ggt ctc tct cta att aaa tgg atc ctg att gtc agg ttt 653 Ser Gly Phe Gly Leu Ser Leu Ile Lys Trp Ile Leu Ile Val Arg Phe 155 160 165 tcc acc tat ttc cct gga tat ttt gat ggt cag tac tgg ctc tgg tgg 701 Ser Thr Tyr Phe Pro Gly Tyr Phe Asp Gly Gln Tyr Trp Leu Trp Trp 170 175 180 gtg ttc ctt gtt tta ggc ttt ctc ctg ttt ctc aga gga ttt atc aat 749 Val Phe Leu Val Leu Gly Phe Leu Leu Phe Leu Arg Gly Phe Ile Asn 185 190 195 tat gca aaa gtt cgg aag atg cca gaa act ttc tca aat ctc ccc agg 797 Tyr Ala Lys Val Arg Lys Met Pro Glu Thr Phe Ser Asn Leu Pro Arg 200 205 210 acc aga gtt ctc ttt att tat taaagatgtt ttctggcaaa ggccttcctg 848 Thr Arg Val Leu Phe Ile Tyr 215 220 catttatgaa ttctctctca agaagcaaga gaacacctgc aggaagtgaa tcaagatgca 908 gaacacagag gaataatcac ctgctttaaa aaaataaagt actgttgaaa agatcatttc 968 tctctatttg ttcctaggtg taaaatttta atagttaatg cagaattctg taatcattga 1028 atcattagtg gttaatgttt gaaaaagctc ttgcaatcaa gtctgtgatg tattaataat 1088 gccttatata ttgtttgtag tcattttaag tagcatgagc catgtccctg tagtcggtag 1148 ggggcagtct tgctttattc atcctccatc tcaaaatgaa cttggaatta aatattgtaa 1208 gatatgtata atgctggcca ttttaaaggg gttttctcaa aagttaaact tttgttatga 1268 ctgtgttttt gcacataatc catatttgct gttcaagtta atctagaaat ttattcaatt 1328 ctgtatgaac acctggaagc aaaatcatag tgcaaaaata catttaaggt gtggtcaaaa 1388 ataagtcttt aattggtaaa taatgagcat taatttttta tagcctgtat tcacaattct 1448 gcggtacctt attgtaccta agggattcta aaggtgttgt cactgtataa aacagaaagc 1508 actaggatac aaatgaagct taattactaa aatgtaattc ttgacactct ttctataatt 1568 agcgttcttc acccccaccc ccacccccca ccccccttat tttccttttg tctcctggtg 1628 attaggccaa agtctgggag taaggagagg attaggtact taggagcaaa gaaagaagta 1688 gcttggaact tttgagatga tccctaacat actgtactac ttgcttttac aatgtgttag 1748 cagaaaccag tgggttataa tgtagaatga tgtgctttct gcccaagtgg taattcatct 1808 tggtttgcta tgttaaaact gtaaatacaa cagaacatta ataaatatct cttgtgtagc 1868 accttt 1874 <210> 250 <211> 221 <212> PRT <213> Homo sapiens <400> 250 Met Ala Leu Ala Leu Ala Ala Leu Ala Ala Val Glu Pro Ala Cys Gly 1 5 10 15 Ser Arg Tyr Trp Gln Leu Gln Asn Glu Glu Glu Ser Gly Glu Pro Glu 20 25 30 Gln Ala Ala Gly Asp Ala Pro Pro Pro Tyr Ser Ser Ile Ser Ala Glu 35 40 45 Ser Ala Ala Tyr Phe Asp Tyr Lys Asp Glu Ser Gly Phe Pro Lys Pro 50 55 60 Pro Ser Tyr Asn Val Ala Thr Thr Leu Pro Ser Tyr Asp Glu Ala Glu 65 70 75 80 Arg Thr Lys Ala Glu Ala Thr Ile Pro Leu Val Pro Gly Arg Asp Glu 85 90 95 Asp Phe Val Gly Arg Asp Asp Leu Asp Asp Ala Asp Gln Leu Arg Ile 100 105 110 Gly Asn Asp Gly Ile Phe Met Leu Thr Phe Phe Met Ala Phe Leu Phe 115 120 125 Asn Trp Ile Gly Phe Phe Leu Ser Phe Cys Leu Thr Thr Ser Ala Ala 130 135 140 Gly Arg Tyr Gly Ala Ile Ser Gly Phe Gly Leu Ser Leu Ile Lys Trp 145 150 155 160 Ile Leu Ile Val Arg Phe Ser Thr Tyr Phe Pro Gly Tyr Phe Asp Gly 165 170 175 Gln Tyr Trp Leu Trp Trp Val Phe Leu Val Leu Gly Phe Leu Leu Phe 180 185 190 Leu Arg Gly Phe Ile Asn Tyr Ala Lys Val Arg Lys Met Pro Glu Thr 195 200 205 Phe Ser Asn Leu Pro Arg Thr Arg Val Leu Phe Ile Tyr 210 215 220 <210> 251 <211> 1463 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (78)..(587) <400> 251 acgcgaaggc tctatcccac gaaaggactg ggtgcacccc agaacgagga cgcggagctt 60 ccctgttcca agcagcg atg cct ggc gga gcc tgc gtg ctg gtg atc gcg 110 Met Pro Gly Gly Ala Cys Val Leu Val Ile Ala 1 5 10 ctg atg ttc ctg gcc tgg ggg gaa gct cag gag tgc tct cct ggg gga 158 Leu Met Phe Leu Ala Trp Gly Glu Ala Gln Glu Cys Ser Pro Gly Gly 15 20 25 cac cag ttt ctt cgg agt cct tat aga agt gtc cgt ttt gac tca tgg 206 His Gln Phe Leu Arg Ser Pro Tyr Arg Ser Val Arg Phe Asp Ser Trp 30 35 40 cac ctc cag cag tca gct gtt caa gac cta ata tgt gac cat tcc ctc 254 His Leu Gln Gln Ser Ala Val Gln Asp Leu Ile Cys Asp His Ser Leu 45 50 55 tcc cct gga tgg tat aga ttt ctc atc ctt gac aga cct gcc gag atg 302 Ser Pro Gly Trp Tyr Arg Phe Leu Ile Leu Asp Arg Pro Ala Glu Met 60 65 70 75 cca acc aaa tgt gtt gag atg aac cat tgt gga act cag gcc ccc atc 350 Pro Thr Lys Cys Val Glu Met Asn His Cys Gly Thr Gln Ala Pro Ile 80 85 90 tgg ctg tct ctg aga gat tca gaa aca ctg cca tct cct ggg gag atc 398 Trp Leu Ser Leu Arg Asp Ser Glu Thr Leu Pro Ser Pro Gly Glu Ile 95 100 105 aag caa ttg aca gct tgt gca aca tgg cag ttt ttg ttc agc act aca 446 Lys Gln Leu Thr Ala Cys Ala Thr Trp Gln Phe Leu Phe Ser Thr Thr 110 115 120 aaa gac tgc tgt ctc ttt caa atc cca gtg tct gta aga aac tgt ggg 494 Lys Asp Cys Cys Leu Phe Gln Ile Pro Val Ser Val Arg Asn Cys Gly 125 130 135 aac ttt tct gta tac tta cta caa cca act cag gga tgt atg ggc tac 542 Asn Phe Ser Val Tyr Leu Leu Gln Pro Thr Gln Gly Cys Met Gly Tyr 140 145 150 155 tgt gcg gaa ggg ttc ttt gcc aag att gta aag tcc ccc cac acg 587 Cys Ala Glu Gly Phe Phe Ala Lys Ile Val Lys Ser Pro His Thr 160 165 170 tgaaagcatc aaaacagaca tctcacattt ttccactgga cataatgatt gagtgtgtta 647 aaaattcttt ggtttcctca agtccattcc tgttttaatt aaaggatgaa gaaggctatt 707 tctgatgcac gattacaccc atgtggttct gatgaaactg aaacaggagg tgattgtgtt 767 cgtcagctgg ctgcctcatt gccacctcca cctgcaggaa ggccagaggt tctggtggag 827 ttgattgagt ccaggctttt ctgtaggtgt tcttttgatg ttcccgctac aaaaaactca 887 gtgggatttc acatagcttg gtctaggctt tcttctcaag aagtcaaaga ggagctgaca 947 caagagacca cagttcaggc attctctctt ttagaacttg atggcataaa tctcagactt 1007 ggagacagga tattctgcag cgcttctgtc tttttcttgg agaatcctca tgtacaaagt 1067 gtagccatcg aaagccaaga attttttgca ggcattaagc tacagcctga attgagcact 1127 atatcagagg atgggaaaga atactacctg aggatagaaa gcacagttcc tattatttgt 1187 tctgaattta gtgagcttga tcaagaatgc aaaatctcat taaaactgaa aactattgat 1247 caaggtaata tactaacttt attttatctt attattagat tgcaaacaat aatgcttttt 1307 tttcctgtag gaaaagtcac tggagtgtac tcatataata aatcatgttg catgttgaca 1367 tcaaatttta gcccaatcat attactaata ctcggccaaa ctgacgattg ccaaagcaat 1427 tcacatttct tcttcttggc cgaaagcata catttt 1463 <210> 252 <211> 170 <212> PRT <213> Homo sapiens <400> 252 Met Pro Gly Gly Ala Cys Val Leu Val Ile Ala Leu Met Phe Leu Ala 1 5 10 15 Trp Gly Glu Ala Gln Glu Cys Ser Pro Gly Gly His Gln Phe Leu Arg 20 25 30 Ser Pro Tyr Arg Ser Val Arg Phe Asp Ser Trp His Leu Gln Gln Ser 35 40 45 Ala Val Gln Asp Leu Ile Cys Asp His Ser Leu Ser Pro Gly Trp Tyr 50 55 60 Arg Phe Leu Ile Leu Asp Arg Pro Ala Glu Met Pro Thr Lys Cys Val 65 70 75 80 Glu Met Asn His Cys Gly Thr Gln Ala Pro Ile Trp Leu Ser Leu Arg 85 90 95 Asp Ser Glu Thr Leu Pro Ser Pro Gly Glu Ile Lys Gln Leu Thr Ala 100 105 110 Cys Ala Thr Trp Gln Phe Leu Phe Ser Thr Thr Lys Asp Cys Cys Leu 115 120 125 Phe Gln Ile Pro Val Ser Val Arg Asn Cys Gly Asn Phe Ser Val Tyr 130 135 140 Leu Leu Gln Pro Thr Gln Gly Cys Met Gly Tyr Cys Ala Glu Gly Phe 145 150 155 160 Phe Ala Lys Ile Val Lys Ser Pro His Thr 165 170 <210> 253 <211> 2103 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (50)..(1480) <400> 253 gacccgccac ccgccgtagc ccgcgcgccc ctggcactca atccccgcc atg tgg ggg 58 Met Trp Gly 1 ctc ctg ctc gcc ctg gcc gcc ttc gcg ccg gcc gtc ggc ccg gct ctg 106 Leu Leu Leu Ala Leu Ala Ala Phe Ala Pro Ala Val Gly Pro Ala Leu 5 10 15 ggg gcg ccc agg aac tcg gtg ctg ggc ctc gcg cag ccc ggg acc acc 154 Gly Ala Pro Arg Asn Ser Val Leu Gly Leu Ala Gln Pro Gly Thr Thr 20 25 30 35 aag gtc cca ggc tcg acc ccg gcc ctg cat agc agc ccg gca cag ccg 202 Lys Val Pro Gly Ser Thr Pro Ala Leu His Ser Ser Pro Ala Gln Pro 40 45 50 ccg gcg gag aca gct aac ggg acc tca gaa cag cat gtc cgg att cga 250 Pro Ala Glu Thr Ala Asn Gly Thr Ser Glu Gln His Val Arg Ile Arg 55 60 65 gtc atc aag aag aaa aag gtc att atg aag aag cgg aag aag cta act 298 Val Ile Lys Lys Lys Lys Val Ile Met Lys Lys Arg Lys Lys Leu Thr 70 75 80 cta act cgc ccc acc cca ctg gtg act gcc ggg ccc ctt gtg acc ccc 346 Leu Thr Arg Pro Thr Pro Leu Val Thr Ala Gly Pro Leu Val Thr Pro 85 90 95 act cca gca ggg acc ctc gac ccc gct gag aaa caa gaa aca ggc tgt 394 Thr Pro Ala Gly Thr Leu Asp Pro Ala Glu Lys Gln Glu Thr Gly Cys 100 105 110 115 cct cct ttg ggt ctg gag tcc ctg cga gtt tca gat agc cgg ctt gag 442 Pro Pro Leu Gly Leu Glu Ser Leu Arg Val Ser Asp Ser Arg Leu Glu 120 125 130 gca tcc agc agc cag tcc ttt ggt ctt gga cca cac cga gga cgg ctc 490 Ala Ser Ser Ser Gln Ser Phe Gly Leu Gly Pro His Arg Gly Arg Leu 135 140 145 aac att cag tca ggc ctg gag gac ggc gat cta tat gat gga gcc tgg 538 Asn Ile Gln Ser Gly Leu Glu Asp Gly Asp Leu Tyr Asp Gly Ala Trp 150 155 160 tgt gct gag gag cag gac gcc gat cca tgg ttt cag gtg gac gct ggg 586 Cys Ala Glu Glu Gln Asp Ala Asp Pro Trp Phe Gln Val Asp Ala Gly 165 170 175 cac ccc acc cgc ttc tcg ggt gtt atc aca cag ggc agg aac tct gtc 634 His Pro Thr Arg Phe Ser Gly Val Ile Thr Gln Gly Arg Asn Ser Val 180 185 190 195 tgg agg tat gac tgg gtc aca tca tac aag gtc cag ttc agc aat gac 682 Trp Arg Tyr Asp Trp Val Thr Ser Tyr Lys Val Gln Phe Ser Asn Asp 200 205 210 agt cgg acc tgg tgg gga agt agg aac cac agc agt ggg atg gac gca 730 Ser Arg Thr Trp Trp Gly Ser Arg Asn His Ser Ser Gly Met Asp Ala 215 220 225 gta ttt cct gcc aat tca gac cca gaa act cca gtg ctg aac ctc ctg 778 Val Phe Pro Ala Asn Ser Asp Pro Glu Thr Pro Val Leu Asn Leu Leu 230 235 240 ccg gag ccc cag gtg gcc cgc ttc att cgc ctg ctg ccc cag acc tgg 826 Pro Glu Pro Gln Val Ala Arg Phe Ile Arg Leu Leu Pro Gln Thr Trp 245 250 255 ctc cag gga ggc gcg cct tgc ctc cgg gca gag atc ctg gcc tgc cca 874 Leu Gln Gly Gly Ala Pro Cys Leu Arg Ala Glu Ile Leu Ala Cys Pro 260 265 270 275 gtc tca gac ccc aat gac cta ttc ctt gag gcc cct gcg tcg gga tcc 922 Val Ser Asp Pro Asn Asp Leu Phe Leu Glu Ala Pro Ala Ser Gly Ser 280 285 290 tct gac cct cta gac ttt cag cat cac aat tac aag gcc atg agg aag 970 Ser Asp Pro Leu Asp Phe Gln His His Asn Tyr Lys Ala Met Arg Lys 295 300 305 ctg atg aag cag gta caa gag caa tgc ccc aac atc acc cgc atc tac 1018 Leu Met Lys Gln Val Gln Glu Gln Cys Pro Asn Ile Thr Arg Ile Tyr 310 315 320 agc att ggg aag agc tac cag ggc ctg aag ctg tat gtg atg gaa atg 1066 Ser Ile Gly Lys Ser Tyr Gln Gly Leu Lys Leu Tyr Val Met Glu Met 325 330 335 tcg gac aag cct ggg gag cat gag ctg ggg gag cct gag gtg cgc tac 1114 Ser Asp Lys Pro Gly Glu His Glu Leu Gly Glu Pro Glu Val Arg Tyr 340 345 350 355 gtg gct ggc atg cat ggg aac gag gcc ctg ggg cgg gag ttg ctt ctg 1162 Val Ala Gly Met His Gly Asn Glu Ala Leu Gly Arg Glu Leu Leu Leu 360 365 370 ctc ctg atg cag ttc ctg tgc cat gag ttc ctg cga ggg aac cca cgg 1210 Leu Leu Met Gln Phe Leu Cys His Glu Phe Leu Arg Gly Asn Pro Arg 375 380 385 gtg acc cgg ctg ctc tct gag atg cgc att cac ctg ctg ccc tcc atg 1258 Val Thr Arg Leu Leu Ser Glu Met Arg Ile His Leu Leu Pro Ser Met 390 395 400 aac cct gat ggc tat gag atc gcc tac cac cgg ggt tca gag ctg gtg 1306 Asn Pro Asp Gly Tyr Glu Ile Ala Tyr His Arg Gly Ser Glu Leu Val 405 410 415 ggc tgg gcc gag ggc cgc tgg aac aac cag agc atc gat ctt aac cat 1354 Gly Trp Ala Glu Gly Arg Trp Asn Asn Gln Ser Ile Asp Leu Asn His 420 425 430 435 aat ttt gct gac ctc aac aca cca ctg tgg gaa gca cag gac gat ggg 1402 Asn Phe Ala Asp Leu Asn Thr Pro Leu Trp Glu Ala Gln Asp Asp Gly 440 445 450 aag gtg ccc cac atc gtc ccc aac cat cac ctg cca cag cca gga ctt 1450 Lys Val Pro His Ile Val Pro Asn His His Leu Pro Gln Pro Gly Leu 455 460 465 ctc cgt gca cgg caa cat cat caa cgg ggc tgactggcac acggtccccg 1500 Leu Arg Ala Arg Gln His His Gln Arg Gly 470 475 ggagcatgaa tgacttcagc tacctacaca ccaactgctt tgaggtcact gtggagctgt 1560 cctgtgacaa gttccctcac gagaatgaat tgccccagga gtgggagaac aacaaagacg 1620 ccctcctcac ctacctggag caggtgcgca tgggcattgc aggagtggtg agggacaagg 1680 acacggagct tgggattgct gacgctgtca ttgccgtgga tgggattaac catgacgtga 1740 ccacggcgtg gggcggggat tattggcgtc tgctgacccc aggggactac atggtgactg 1800 ccagtgccga gggctaccat tcagtgacac ggaactgtcg ggtcaccttt gaagagggcc 1860 ccttcccctg caatttcgtg ctcaccaaga ctcccaaaca gaggctgcgc gagctgctgg 1920 cagctggggc caaggtgccc ccggaccttc gcaggcgcct ggagcggcta aggggacaga 1980 aggattgata cctgcggttt aagagcccta gggcaggctg gacctgtcaa gacgggaagg 2040 ggaagagtag tgagggaggg acaaagtgag gaaaaggtgc tcattaaagc taccgggcac 2100 ctt 2103 <210> 254 <211> 477 <212> PRT <213> Homo sapiens <400> 254 Met Trp Gly Leu Leu Leu Ala Leu Ala Ala Phe Ala Pro Ala Val Gly 1 5 10 15 Pro Ala Leu Gly Ala Pro Arg Asn Ser Val Leu Gly Leu Ala Gln Pro 20 25 30 Gly Thr Thr Lys Val Pro Gly Ser Thr Pro Ala Leu His Ser Ser Pro 35 40 45 Ala Gln Pro Pro Ala Glu Thr Ala Asn Gly Thr Ser Glu Gln His Val 50 55 60 Arg Ile Arg Val Ile Lys Lys Lys Lys Val Ile Met Lys Lys Arg Lys 65 70 75 80 Lys Leu Thr Leu Thr Arg Pro Thr Pro Leu Val Thr Ala Gly Pro Leu 85 90 95 Val Thr Pro Thr Pro Ala Gly Thr Leu Asp Pro Ala Glu Lys Gln Glu 100 105 110 Thr Gly Cys Pro Pro Leu Gly Leu Glu Ser Leu Arg Val Ser Asp Ser 115 120 125 Arg Leu Glu Ala Ser Ser Ser Gln Ser Phe Gly Leu Gly Pro His Arg 130 135 140 Gly Arg Leu Asn Ile Gln Ser Gly Leu Glu Asp Gly Asp Leu Tyr Asp 145 150 155 160 Gly Ala Trp Cys Ala Glu Glu Gln Asp Ala Asp Pro Trp Phe Gln Val 165 170 175 Asp Ala Gly His Pro Thr Arg Phe Ser Gly Val Ile Thr Gln Gly Arg 180 185 190 Asn Ser Val Trp Arg Tyr Asp Trp Val Thr Ser Tyr Lys Val Gln Phe 195 200 205 Ser Asn Asp Ser Arg Thr Trp Trp Gly Ser Arg Asn His Ser Ser Gly 210 215 220 Met Asp Ala Val Phe Pro Ala Asn Ser Asp Pro Glu Thr Pro Val Leu 225 230 235 240 Asn Leu Leu Pro Glu Pro Gln Val Ala Arg Phe Ile Arg Leu Leu Pro 245 250 255 Gln Thr Trp Leu Gln Gly Gly Ala Pro Cys Leu Arg Ala Glu Ile Leu 260 265 270 Ala Cys Pro Val Ser Asp Pro Asn Asp Leu Phe Leu Glu Ala Pro Ala 275 280 285 Ser Gly Ser Ser Asp Pro Leu Asp Phe Gln His His Asn Tyr Lys Ala 290 295 300 Met Arg Lys Leu Met Lys Gln Val Gln Glu Gln Cys Pro Asn Ile Thr 305 310 315 320 Arg Ile Tyr Ser Ile Gly Lys Ser Tyr Gln Gly Leu Lys Leu Tyr Val 325 330 335 Met Glu Met Ser Asp Lys Pro Gly Glu His Glu Leu Gly Glu Pro Glu 340 345 350 Val Arg Tyr Val Ala Gly Met His Gly Asn Glu Ala Leu Gly Arg Glu 355 360 365 Leu Leu Leu Leu Leu Met Gln Phe Leu Cys His Glu Phe Leu Arg Gly 370 375 380 Asn Pro Arg Val Thr Arg Leu Leu Ser Glu Met Arg Ile His Leu Leu 385 390 395 400 Pro Ser Met Asn Pro Asp Gly Tyr Glu Ile Ala Tyr His Arg Gly Ser 405 410 415 Glu Leu Val Gly Trp Ala Glu Gly Arg Trp Asn Asn Gln Ser Ile Asp 420 425 430 Leu Asn His Asn Phe Ala Asp Leu Asn Thr Pro Leu Trp Glu Ala Gln 435 440 445 Asp Asp Gly Lys Val Pro His Ile Val Pro Asn His His Leu Pro Gln 450 455 460 Pro Gly Leu Leu Arg Ala Arg Gln His His Gln Arg Gly 465 470 475 <210> 255 <211> 1410 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (130)..(1266) <400> 255 ggctaccttg tggtggttat tgggttagag aatgtgttgg tgctcaccaa gtctgtggtc 60 tcaaccccgg tagacctgga ggtgaagctg cggatcgccc aaggcctaag cagcgagagc 120 tggtccatc atg aag aac atg gcc acg gag ctg ggc atc atc ctc atc ggc 171 Met Lys Asn Met Ala Thr Glu Leu Gly Ile Ile Leu Ile Gly 1 5 10 tac ttc acc cta gtg ccc gcc atc cag gag ttc tgt ctc ttt gct gtc 219 Tyr Phe Thr Leu Val Pro Ala Ile Gln Glu Phe Cys Leu Phe Ala Val 15 20 25 30 gtg ggg ctg gtg act gac ttc ttc ctt cag atg ctg ttt ttc acc act 267 Val Gly Leu Val Thr Asp Phe Phe Leu Gln Met Leu Phe Phe Thr Thr 35 40 45 gtc ctg tcc att gac att cgc cgg atg gag cta gca gac ctg aac aag 315 Val Leu Ser Ile Asp Ile Arg Arg Met Glu Leu Ala Asp Leu Asn Lys 50 55 60 cga ctg ccc cct gag gcc tgc ctg ccc tca gcc aag cca gtg ggg cag 363 Arg Leu Pro Pro Glu Ala Cys Leu Pro Ser Ala Lys Pro Val Gly Gln 65 70 75 cca acg cgc tac gag cgg agc agc ggc cgg ctg gag gtg tgg gac tcc 411 Pro Thr Arg Tyr Glu Arg Ser Ser Gly Arg Leu Glu Val Trp Asp Ser 80 85 90 att gaa ggg gtg ctg tgc tgc agc agc gag gag gtc tcc tca ggc att 459 Ile Glu Gly Val Leu Cys Cys Ser Ser Glu Glu Val Ser Ser Gly Ile 95 100 105 110 acc gct ctg gtg ttc ttg gac aaa ggg att gtg gct gca cgg ctc aac 507 Thr Ala Leu Val Phe Leu Asp Lys Gly Ile Val Ala Ala Arg Leu Asn 115 120 125 ggt tcc ctt gat ttc ttc tcc ttg gag acc cac act gcc ctc agc ccc 555 Gly Ser Leu Asp Phe Phe Ser Leu Glu Thr His Thr Ala Leu Ser Pro 130 135 140 ctg cag ttt aga ggg acc cca ggg cgg ggc agt tcc cct gcc tct cca 603 Leu Gln Phe Arg Gly Thr Pro Gly Arg Gly Ser Ser Pro Ala Ser Pro 145 150 155 gtg tac agc agc agc gac aca gtg gcc tgt cac ctg acc cac aca gtg 651 Val Tyr Ser Ser Ser Asp Thr Val Ala Cys His Leu Thr His Thr Val 160 165 170 ccc tgt gca cac caa aaa ccc atc aca gcc ctg aaa gcc gct gct ggg 699 Pro Cys Ala His Gln Lys Pro Ile Thr Ala Leu Lys Ala Ala Ala Gly 175 180 185 190 cgc ttg gtg act ggg agc caa gac cac aca ctg aga gtg ttc cgt ctg 747 Arg Leu Val Thr Gly Ser Gln Asp His Thr Leu Arg Val Phe Arg Leu 195 200 205 gag gac tcg tgc tgc ctc ttc acc ctt cag ggc cac tca ggg gcc atc 795 Glu Asp Ser Cys Cys Leu Phe Thr Leu Gln Gly His Ser Gly Ala Ile 210 215 220 acg acc gtg tac att gac cag acc atg gtg ctg gcc agt gga gga caa 843 Thr Thr Val Tyr Ile Asp Gln Thr Met Val Leu Ala Ser Gly Gly Gln 225 230 235 gat ggg gcc atc tgc ctg tgg gat gta ctg act ggc agc cgg gtc agc 891 Asp Gly Ala Ile Cys Leu Trp Asp Val Leu Thr Gly Ser Arg Val Ser 240 245 250 cat gtg ttt gct cac cgt ggg gat gtc acc tcc ctt acc tgt acc acc 939 His Val Phe Ala His Arg Gly Asp Val Thr Ser Leu Thr Cys Thr Thr 255 260 265 270 tcc tgt gtc atc agc agt ggc ctg gat gac ctc atc agc atc tgg gac 987 Ser Cys Val Ile Ser Ser Gly Leu Asp Asp Leu Ile Ser Ile Trp Asp 275 280 285 cgc agc aca ggc atc aag ttc tac tcc att cag cag gac ctg ggc tgt 1035 Arg Ser Thr Gly Ile Lys Phe Tyr Ser Ile Gln Gln Asp Leu Gly Cys 290 295 300 ggt gca agc ttg ggt gtc atc tca gac aac ctg ctg gtg act ggc ggc 1083 Gly Ala Ser Leu Gly Val Ile Ser Asp Asn Leu Leu Val Thr Gly Gly 305 310 315 cag ggc tgt gtc tcc ttt tgg gac cta aac tac ggg gac ctg tta cag 1131 Gln Gly Cys Val Ser Phe Trp Asp Leu Asn Tyr Gly Asp Leu Leu Gln 320 325 330 aca gtc tac ctg ggg aag aac agt gag gcc cag cct gcc cgc cag atc 1179 Thr Val Tyr Leu Gly Lys Asn Ser Glu Ala Gln Pro Ala Arg Gln Ile 335 340 345 350 ctg gtg ctg gac aac gct gcc att gtc tgc aac ttt ggc agt gag ctc 1227 Leu Val Leu Asp Asn Ala Ala Ile Val Cys Asn Phe Gly Ser Glu Leu 355 360 365 agc ctg gtg tat gtg ccc tct gtg ctg gag aag ctg gac tgagcgcagg 1276 Ser Leu Val Tyr Val Pro Ser Val Leu Glu Lys Leu Asp 370 375 gcctccttgc ccaggcagga ggctggggtg ctgtgtgggg gccaatgcac tgaacctgga 1336 cttgggggaa agagccgagt atcttccagc cgctgcctcc tgactgtaat aatattaaac 1396 ttttttaaaa aacc 1410 <210> 256 <211> 379 <212> PRT <213> Homo sapiens <400> 256 Met Lys Asn Met Ala Thr Glu Leu Gly Ile Ile Leu Ile Gly Tyr Phe 1 5 10 15 Thr Leu Val Pro Ala Ile Gln Glu Phe Cys Leu Phe Ala Val Val Gly 20 25 30 Leu Val Thr Asp Phe Phe Leu Gln Met Leu Phe Phe Thr Thr Val Leu 35 40 45 Ser Ile Asp Ile Arg Arg Met Glu Leu Ala Asp Leu Asn Lys Arg Leu 50 55 60 Pro Pro Glu Ala Cys Leu Pro Ser Ala Lys Pro Val Gly Gln Pro Thr 65 70 75 80 Arg Tyr Glu Arg Ser Ser Gly Arg Leu Glu Val Trp Asp Ser Ile Glu 85 90 95 Gly Val Leu Cys Cys Ser Ser Glu Glu Val Ser Ser Gly Ile Thr Ala 100 105 110 Leu Val Phe Leu Asp Lys Gly Ile Val Ala Ala Arg Leu Asn Gly Ser 115 120 125 Leu Asp Phe Phe Ser Leu Glu Thr His Thr Ala Leu Ser Pro Leu Gln 130 135 140 Phe Arg Gly Thr Pro Gly Arg Gly Ser Ser Pro Ala Ser Pro Val Tyr 145 150 155 160 Ser Ser Ser Asp Thr Val Ala Cys His Leu Thr His Thr Val Pro Cys 165 170 175 Ala His Gln Lys Pro Ile Thr Ala Leu Lys Ala Ala Ala Gly Arg Leu 180 185 190 Val Thr Gly Ser Gln Asp His Thr Leu Arg Val Phe Arg Leu Glu Asp 195 200 205 Ser Cys Cys Leu Phe Thr Leu Gln Gly His Ser Gly Ala Ile Thr Thr 210 215 220 Val Tyr Ile Asp Gln Thr Met Val Leu Ala Ser Gly Gly Gln Asp Gly 225 230 235 240 Ala Ile Cys Leu Trp Asp Val Leu Thr Gly Ser Arg Val Ser His Val 245 250 255 Phe Ala His Arg Gly Asp Val Thr Ser Leu Thr Cys Thr Thr Ser Cys 260 265 270 Val Ile Ser Ser Gly Leu Asp Asp Leu Ile Ser Ile Trp Asp Arg Ser 275 280 285 Thr Gly Ile Lys Phe Tyr Ser Ile Gln Gln Asp Leu Gly Cys Gly Ala 290 295 300 Ser Leu Gly Val Ile Ser Asp Asn Leu Leu Val Thr Gly Gly Gln Gly 305 310 315 320 Cys Val Ser Phe Trp Asp Leu Asn Tyr Gly Asp Leu Leu Gln Thr Val 325 330 335 Tyr Leu Gly Lys Asn Ser Glu Ala Gln Pro Ala Arg Gln Ile Leu Val 340 345 350 Leu Asp Asn Ala Ala Ile Val Cys Asn Phe Gly Ser Glu Leu Ser Leu 355 360 365 Val Tyr Val Pro Ser Val Leu Glu Lys Leu Asp 370 375 <210> 257 <211> 1483 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (92)..(529) <400> 257 atcctcctag gacccggtcg gtagtcgtcg ccccagcccg ccgggggcgc agcgcccgag 60 ccgcggccct cgagacggga ccgagagcat c atg ggc agc act gtc ccg cgc 112 Met Gly Ser Thr Val Pro Arg 1 5 tcc gcc tcc gtg ctg ctt ctg ctg ctg ctc ctg cgc cgg gcc gag cag 160 Ser Ala Ser Val Leu Leu Leu Leu Leu Leu Leu Arg Arg Ala Glu Gln 10 15 20 ccc tgc ggg gcc gag ctc acc ttc gag ctg ccg gac aac gcc aag cag 208 Pro Cys Gly Ala Glu Leu Thr Phe Glu Leu Pro Asp Asn Ala Lys Gln 25 30 35 tgc ttc cac gag gag gtg gag cag ggc gtg aag ttc tcc ctg gat tac 256 Cys Phe His Glu Glu Val Glu Gln Gly Val Lys Phe Ser Leu Asp Tyr 40 45 50 55 cag gtc atc act gga ggc cac tac gat gtt gac tgc tat gta gag gac 304 Gln Val Ile Thr Gly Gly His Tyr Asp Val Asp Cys Tyr Val Glu Asp 60 65 70 ccc cag ggg aac acc atc tac aga gaa acg aag aag cag tac gac agc 352 Pro Gln Gly Asn Thr Ile Tyr Arg Glu Thr Lys Lys Gln Tyr Asp Ser 75 80 85 ttc acg tac cgg gct gaa gtc aag ggc gtt tat cag ttt tgc ttc agt 400 Phe Thr Tyr Arg Ala Glu Val Lys Gly Val Tyr Gln Phe Cys Phe Ser 90 95 100 aat ggg ttt tcc acc ttc tct cac aag acc gtc tac ttt gac ttt caa 448 Asn Gly Phe Ser Thr Phe Ser His Lys Thr Val Tyr Phe Asp Phe Gln 105 110 115 gtg ggc gat gag cct ccc att ctc cca gac atg ggg aac agg gtc aca 496 Val Gly Asp Glu Pro Pro Ile Leu Pro Asp Met Gly Asn Arg Val Thr 120 125 130 135 gct ctc acc cag ggc ttc agg gtc ttc tgc ctg tagctgccaa aggaagagag 549 Ala Leu Thr Gln Gly Phe Arg Val Phe Cys Leu 140 145 aatgagaaaa gcccatctac ctcttaaaag cccaggccca gtgggaatac gtatcacctg 609 ctcatgtccc atggatggag tccgcctgcg tgaccatcca tgaggctctg aaaacggtga 669 ttgactccca gacgcattac cggctgcggg aggcccagga ccgggcccga gcggaagacc 729 ttaatagccg agtctcttac tggtctgttg gcgagacgat tgccctgttc gtggtcagct 789 tcagtcaggt gctactgttg aaaagcttct tcacagaaaa acgacccatc agcagggcag 849 tccactccta gccccggcat cctgctctag ggcccctcat gccccaggct ggagcagctc 909 tcctaggtca cagcctgctg ggctgggtcg cgtagcccag ggtggaggca gaacgatgct 969 gctgtggtag ccctttgcct ttcatgccca tgcttgattc ttgcacctca gcagctgaag 1029 gtctcagaga ccagtaatca gaaggcatcc gactgcatta agtgtgcagc gctgaaaaga 1089 catttacaac taggccaggg attagccact gtgggagggt ggacaggcaa tggttcagtg 1149 gcctggctgt tggcaggaac tccaagtgcc caggcctctt gggcagctta gggccctgcc 1209 tctgtttcat gatgcatggg tcatttgtct tgggtgtcct atcccatatg gagaagaaag 1269 gggctctaag ttctggctct tctttctttg gggttctctg tacctgagga aaccaggccc 1329 tgggtgactt tgcagatctg ctcaccctcg gtgagcaaca gtgtcagcca tgcaagcagg 1389 acagaatggt gactgggtgc ccttggtgag ctgtgtattt cctaggaggt agaaaactgt 1449 gggaaactgt ggctaataaa aactaagtgt gagc 1483 <210> 258 <211> 146 <212> PRT <213> Homo sapiens <400> 258 Met Gly Ser Thr Val Pro Arg Ser Ala Ser Val Leu Leu Leu Leu Leu 1 5 10 15 Leu Leu Arg Arg Ala Glu Gln Pro Cys Gly Ala Glu Leu Thr Phe Glu 20 25 30 Leu Pro Asp Asn Ala Lys Gln Cys Phe His Glu Glu Val Glu Gln Gly 35 40 45 Val Lys Phe Ser Leu Asp Tyr Gln Val Ile Thr Gly Gly His Tyr Asp 50 55 60 Val Asp Cys Tyr Val Glu Asp Pro Gln Gly Asn Thr Ile Tyr Arg Glu 65 70 75 80 Thr Lys Lys Gln Tyr Asp Ser Phe Thr Tyr Arg Ala Glu Val Lys Gly 85 90 95 Val Tyr Gln Phe Cys Phe Ser Asn Gly Phe Ser Thr Phe Ser His Lys 100 105 110 Thr Val Tyr Phe Asp Phe Gln Val Gly Asp Glu Pro Pro Ile Leu Pro 115 120 125 Asp Met Gly Asn Arg Val Thr Ala Leu Thr Gln Gly Phe Arg Val Phe 130 135 140 Cys Leu 145 <210> 259 <211> 1784 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (55)..(867) <400> 259 gcagagtgca gggccacgtc gcttttgctg taccggggac cacgcgtctc atcc atg 57 Met 1 gct tcc gcg gac tcg cgc cgg gtg gca gat ggc ggc ggt gcc ggg ggc 105 Ala Ser Ala Asp Ser Arg Arg Val Ala Asp Gly Gly Gly Ala Gly Gly 5 10 15 acc ttc cag ccc tac cta gac acc ttg cgg cag gag ctg cag cag acg 153 Thr Phe Gln Pro Tyr Leu Asp Thr Leu Arg Gln Glu Leu Gln Gln Thr 20 25 30 gac cca acg ctg ttg tca gta gtg gtg gcg gtt ctt gcg gtg ctg ctg 201 Asp Pro Thr Leu Leu Ser Val Val Val Ala Val Leu Ala Val Leu Leu 35 40 45 acg cta gtc ttc tgg aag tta atc cgg agc aga agg agc agt cag aga 249 Thr Leu Val Phe Trp Lys Leu Ile Arg Ser Arg Arg Ser Ser Gln Arg 50 55 60 65 gct gtt ctt ctt gtt ggc ctt tgt gat tcc ggg aaa acg ttg ctc ttt 297 Ala Val Leu Leu Val Gly Leu Cys Asp Ser Gly Lys Thr Leu Leu Phe 70 75 80 gtc agg ttg tta aca ggc ctt tat aga gac act cag acg tcc att act 345 Val Arg Leu Leu Thr Gly Leu Tyr Arg Asp Thr Gln Thr Ser Ile Thr 85 90 95 gac agc tgt gct gta tac aga gtc aac aat aac agg ggc aat agt ctg 393 Asp Ser Cys Ala Val Tyr Arg Val Asn Asn Asn Arg Gly Asn Ser Leu 100 105 110 acc ttg att gac ctt ccc ggc cat gag agt ttg agg ctt cag ttc tta 441 Thr Leu Ile Asp Leu Pro Gly His Glu Ser Leu Arg Leu Gln Phe Leu 115 120 125 gag cgg ttt aag tct tca gcc agg gct att gtg ttt gtt gtg gat agt 489 Glu Arg Phe Lys Ser Ser Ala Arg Ala Ile Val Phe Val Val Asp Ser 130 135 140 145 gca gca ttc cag cga gag gtg aaa gat gtg gct gag ttt ctg tat caa 537 Ala Ala Phe Gln Arg Glu Val Lys Asp Val Ala Glu Phe Leu Tyr Gln 150 155 160 gtc ctc att gac agt atg ggt ctg aag aat aca cca tca ttc tta ata 585 Val Leu Ile Asp Ser Met Gly Leu Lys Asn Thr Pro Ser Phe Leu Ile 165 170 175 gcc tgc aat aag caa gat att gca atg gca aaa tca gca aag tta att 633 Ala Cys Asn Lys Gln Asp Ile Ala Met Ala Lys Ser Ala Lys Leu Ile 180 185 190 caa cag cag ctg gag aaa gaa ctc aac acc tta cga gtt acc cgt tct 681 Gln Gln Gln Leu Glu Lys Glu Leu Asn Thr Leu Arg Val Thr Arg Ser 195 200 205 gct gcc ccc agc aca ctg gac agt tcc agc act gcc cct gct cag ctg 729 Ala Ala Pro Ser Thr Leu Asp Ser Ser Ser Thr Ala Pro Ala Gln Leu 210 215 220 225 ggg aag aaa ggc aaa gag ttt gaa ttc tca cag ttg ccc ctc aaa gtg 777 Gly Lys Lys Gly Lys Glu Phe Glu Phe Ser Gln Leu Pro Leu Lys Val 230 235 240 gag ttc ctg gag tgc agt gcc aag ggt gga aga ggg gac gtg ggc tct 825 Glu Phe Leu Glu Cys Ser Ala Lys Gly Gly Arg Gly Asp Val Gly Ser 245 250 255 gct gac atc cag gac ttg gag aaa tgg ctg gct aaa att gcc 867 Ala Asp Ile Gln Asp Leu Glu Lys Trp Leu Ala Lys Ile Ala 260 265 270 tgagaggcag ctctaaagca caagacctgg atgtgtgaca cacagttttg gaaaaaggtc 927 tgtggtagtc tggagttgat gaggaagggg tacaagatgt ggttagaaac atttctttgt 987 tctggaaaca aagtactgtt gaaaccagct tggaattttt tttttttttt tttttaagtt 1047 cagttctccc ttatggctgc ctttcaaaca agtacctttt atctgatgcc tgtatcttcc 1107 ctttgttaag gtgtaacttg atgtagggtc aaggtttttg tgacaacagg cagactccac 1167 acagagagga tatgatgaga atatggccat cacctgaaaa gttttcttat cttctgtgct 1227 tttggtccct ggaaacaaat ccgcctatgt atgaagctag ttgatttcca gttgcactat 1287 ttccagttgc ctctgaagtt cacaggcaat acattgtcta gtcctttgcg aatttctctg 1347 atttgtgggc acagttatga agtttcccca catgtgaaga caggtacaaa atagcagagc 1407 caagcagaca gtgggtctat tcttcattag ctcagtgact tgtccacact cgtcttagca 1467 cttacgtttc aaaagcttgt cacaaaccct tggagtcatt cccagataat agaactggaa 1527 atgataaatc ccctaatgcc aagggtctag tgtgttctta gtggttatac tgggaagtgt 1587 gtggagattt aggtgctgct ctgctgctct ggatggctga aggctcctgg gccatcttca 1647 tgtgctgctt gaagagctcc tattttgtac tcctggctag aatgctgtgg aacaaataca 1707 aagtgaaaaa agttctctgt agatttctga agtgcatatt cattgatgcc aagaaaaaaa 1767 aaaaagttgc ctttttg 1784 <210> 260 <211> 271 <212> PRT <213> Homo sapiens <400> 260 Met Ala Ser Ala Asp Ser Arg Arg Val Ala Asp Gly Gly Gly Ala Gly 1 5 10 15 Gly Thr Phe Gln Pro Tyr Leu Asp Thr Leu Arg Gln Glu Leu Gln Gln 20 25 30 Thr Asp Pro Thr Leu Leu Ser Val Val Val Ala Val Leu Ala Val Leu 35 40 45 Leu Thr Leu Val Phe Trp Lys Leu Ile Arg Ser Arg Arg Ser Ser Gln 50 55 60 Arg Ala Val Leu Leu Val Gly Leu Cys Asp Ser Gly Lys Thr Leu Leu 65 70 75 80 Phe Val Arg Leu Leu Thr Gly Leu Tyr Arg Asp Thr Gln Thr Ser Ile 85 90 95 Thr Asp Ser Cys Ala Val Tyr Arg Val Asn Asn Asn Arg Gly Asn Ser 100 105 110 Leu Thr Leu Ile Asp Leu Pro Gly His Glu Ser Leu Arg Leu Gln Phe 115 120 125 Leu Glu Arg Phe Lys Ser Ser Ala Arg Ala Ile Val Phe Val Val Asp 130 135 140 Ser Ala Ala Phe Gln Arg Glu Val Lys Asp Val Ala Glu Phe Leu Tyr 145 150 155 160 Gln Val Leu Ile Asp Ser Met Gly Leu Lys Asn Thr Pro Ser Phe Leu 165 170 175 Ile Ala Cys Asn Lys Gln Asp Ile Ala Met Ala Lys Ser Ala Lys Leu 180 185 190 Ile Gln Gln Gln Leu Glu Lys Glu Leu Asn Thr Leu Arg Val Thr Arg 195 200 205 Ser Ala Ala Pro Ser Thr Leu Asp Ser Ser Ser Thr Ala Pro Ala Gln 210 215 220 Leu Gly Lys Lys Gly Lys Glu Phe Glu Phe Ser Gln Leu Pro Leu Lys 225 230 235 240 Val Glu Phe Leu Glu Cys Ser Ala Lys Gly Gly Arg Gly Asp Val Gly 245 250 255 Ser Ala Asp Ile Gln Asp Leu Glu Lys Trp Leu Ala Lys Ile Ala 260 265 270 <210> 261 <211> 1709 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (89)..(826) <400> 261 agctccagtc ctggcatctg cccgaggaga ccacgctccc ggagctctgc tgtcttctca 60 gggagactct gaggctctgt tgagaatc atg ctt tgg agg cag ctc atc tat 112 Met Leu Trp Arg Gln Leu Ile Tyr 1 5 tgg caa ctg ctg gct ttg ttt ttc ctc cct ttt tgc ctg tgt caa gat 160 Trp Gln Leu Leu Ala Leu Phe Phe Leu Pro Phe Cys Leu Cys Gln Asp 10 15 20 gaa tac atg gag tct cca caa acc gga gga cta ccc cca gac tgc agt 208 Glu Tyr Met Glu Ser Pro Gln Thr Gly Gly Leu Pro Pro Asp Cys Ser 25 30 35 40 aag tgt tgt cat gga gac tac agc ttt cga ggc tac caa ggc ccc cct 256 Lys Cys Cys His Gly Asp Tyr Ser Phe Arg Gly Tyr Gln Gly Pro Pro 45 50 55 ggg cca ccg ggc cct cct ggc att cca gga aac cat gga aac aat ggc 304 Gly Pro Pro Gly Pro Pro Gly Ile Pro Gly Asn His Gly Asn Asn Gly 60 65 70 aac aat gga gcc act ggt cat gaa gga gcc aaa ggt gag aag ggc gac 352 Asn Asn Gly Ala Thr Gly His Glu Gly Ala Lys Gly Glu Lys Gly Asp 75 80 85 aaa ggt gac ctg ggg cct cga ggg gag cgg ggg cag cat ggc ccc aaa 400 Lys Gly Asp Leu Gly Pro Arg Gly Glu Arg Gly Gln His Gly Pro Lys 90 95 100 gga gag aag ggc tac ccg ggg att cca cca gaa ctt cag att gca ttc 448 Gly Glu Lys Gly Tyr Pro Gly Ile Pro Pro Glu Leu Gln Ile Ala Phe 105 110 115 120 atg gct tct ctg gca acc cac ttc agc aat cag aac agt ggg att atc 496 Met Ala Ser Leu Ala Thr His Phe Ser Asn Gln Asn Ser Gly Ile Ile 125 130 135 ttc agc agt gtt gag acc aac att gga aac ttc ttt gat gtc atg act 544 Phe Ser Ser Val Glu Thr Asn Ile Gly Asn Phe Phe Asp Val Met Thr 140 145 150 ggt aga ttt ggg gcc cca gta tca ggt gtg tat ttc ttc acc ttc agc 592 Gly Arg Phe Gly Ala Pro Val Ser Gly Val Tyr Phe Phe Thr Phe Ser 155 160 165 atg atg aag cat gag gat gtt gag gaa gtg tat gtg tac ctt atg cac 640 Met Met Lys His Glu Asp Val Glu Glu Val Tyr Val Tyr Leu Met His 170 175 180 aat ggc aac aca gtc ttc agc atg tac agc tat gaa atg aag ggc aaa 688 Asn Gly Asn Thr Val Phe Ser Met Tyr Ser Tyr Glu Met Lys Gly Lys 185 190 195 200 tca gat aca tcc agc aat cat gct gtg ctg aag cta gcc aaa ggg gat 736 Ser Asp Thr Ser Ser Asn His Ala Val Leu Lys Leu Ala Lys Gly Asp 205 210 215 gag gtt tgg ctg cga atg ggc aat ggc gct ctc cat ggg gac cac caa 784 Glu Val Trp Leu Arg Met Gly Asn Gly Ala Leu His Gly Asp His Gln 220 225 230 cgc ttc tcc acc ttt gca gga ttc ctg ctc ttt gaa act aag 826 Arg Phe Ser Thr Phe Ala Gly Phe Leu Leu Phe Glu Thr Lys 235 240 245 taaatatatg actagaatag ctccactttg gggaagactt gtagctgagc tgatttgtta 886 cgatctgagg aacattaaag ttgagggttt tacattgctg tattcaaaaa attattggtt 946 gcaatgttgt tcacgctaca ggtacaccaa taatgttgga caattcaggg gctcagaaga 1006 atcaaccaca aaatagtctt ctcagatgac cttgactaat atactcagca tctttatcac 1066 tctttccttg gcacctaaaa gataattctc ctctgacgca ggttggaaat atttttttct 1126 atcacagaag tcatttgcaa agaattttga ctactctgct tttaatttaa taccagtttt 1186 caggaacccc tgaagtttta agttcattat tctttataac atttgagaga atcggatgta 1246 gtgatatgac agggctgggg caagaacagg ggcactagct gccttattag ctaatttagt 1306 gccctccgtg ttcagcttag cctttgaccc tttccttttg atccacaaaa tacattaaaa 1366 ctctgaattc acatacaatg ctattttaaa gtcaatagat tttagctata aagtgcttga 1426 ccagtaatgt ggttgtaatt ttgtgtatgt tcccccacat cgcccccaac ttcggatgtg 1486 gggtcaggag gttgaggttc actattaaca aatgtcataa atatctcata gaggtacagt 1546 gccaatagat attcaaatgt tgcatgttga ccagagggat tttatatctg aagaacatac 1606 actattaata aataccttag agaaagattt tgacctggct ttagataaaa ctgtggcaag 1666 aaaaatgtaa tgagcaatat atggaaataa acacaccttt gtt 1709 <210> 262 <211> 246 <212> PRT <213> Homo sapiens <400> 262 Met Leu Trp Arg Gln Leu Ile Tyr Trp Gln Leu Leu Ala Leu Phe Phe 1 5 10 15 Leu Pro Phe Cys Leu Cys Gln Asp Glu Tyr Met Glu Ser Pro Gln Thr 20 25 30 Gly Gly Leu Pro Pro Asp Cys Ser Lys Cys Cys His Gly Asp Tyr Ser 35 40 45 Phe Arg Gly Tyr Gln Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Ile 50 55 60 Pro Gly Asn His Gly Asn Asn Gly Asn Asn Gly Ala Thr Gly His Glu 65 70 75 80 Gly Ala Lys Gly Glu Lys Gly Asp Lys Gly Asp Leu Gly Pro Arg Gly 85 90 95 Glu Arg Gly Gln His Gly Pro Lys Gly Glu Lys Gly Tyr Pro Gly Ile 100 105 110 Pro Pro Glu Leu Gln Ile Ala Phe Met Ala Ser Leu Ala Thr His Phe 115 120 125 Ser Asn Gln Asn Ser Gly Ile Ile Phe Ser Ser Val Glu Thr Asn Ile 130 135 140 Gly Asn Phe Phe Asp Val Met Thr Gly Arg Phe Gly Ala Pro Val Ser 145 150 155 160 Gly Val Tyr Phe Phe Thr Phe Ser Met Met Lys His Glu Asp Val Glu 165 170 175 Glu Val Tyr Val Tyr Leu Met His Asn Gly Asn Thr Val Phe Ser Met 180 185 190 Tyr Ser Tyr Glu Met Lys Gly Lys Ser Asp Thr Ser Ser Asn His Ala 195 200 205 Val Leu Lys Leu Ala Lys Gly Asp Glu Val Trp Leu Arg Met Gly Asn 210 215 220 Gly Ala Leu His Gly Asp His Gln Arg Phe Ser Thr Phe Ala Gly Phe 225 230 235 240 Leu Leu Phe Glu Thr Lys 245 <210> 263 <211> 2499 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (208)..(1008) <400> 263 actccgtgct ggaagtagga ggagagtcag gactcccagg acagagagtg cacaaactac 60 ccagcacagc cccctccgcc ccctctggag gctgaagagg gattccagcc cctgccaccc 120 acagacacgg gctgactggg gtgtctgccc cccttggggg ggggcagcac agggcctcag 180 gcctgggtgc cacctggcac ctagaag atg cct gtg ccc tgg ttc ttg ctg tcc 234 Met Pro Val Pro Trp Phe Leu Leu Ser 1 5 ttg gca ctg ggc cga agc cca gtg gtc ctt tct ctg gag agg ctt gtg 282 Leu Ala Leu Gly Arg Ser Pro Val Val Leu Ser Leu Glu Arg Leu Val 10 15 20 25 ggg cct cag gac gct acc cac tgc tct ccg ggc ctc tcc tgc cgc ctc 330 Gly Pro Gln Asp Ala Thr His Cys Ser Pro Gly Leu Ser Cys Arg Leu 30 35 40 tgg gac agt gac ata ctc tgc ctg cct ggg gac atc gtg cct gct ccg 378 Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp Ile Val Pro Ala Pro 45 50 55 ggc ccc gtg ctg gcg cct acg cac ctg cag aca gag ctg gtg ctg agg 426 Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr Glu Leu Val Leu Arg 60 65 70 tgc cag aag gag acc gac tgt gac ctc tgt ctg cgt gtg gct gtc cac 474 Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu Arg Val Ala Val His 75 80 85 ttg gcc gtg cat ggg cac tgg gaa gag cct gaa gat gag gaa aag ttt 522 Leu Ala Val His Gly His Trp Glu Glu Pro Glu Asp Glu Glu Lys Phe 90 95 100 105 gga gga gca gct gac tca ggg gtg gag gag cct agg aat gcc tct ctc 570 Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg Asn Ala Ser Leu 110 115 120 cag gcc caa gtc gtg ctc tcc ttc cag gcc tac cct act gcc cgc tgc 618 Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 125 130 135 gtc ctg ctg gag gtg caa gtg cct gct gcc ctt gtg cag ttt ggt cag 666 Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 140 145 150 tct gtg ggc tct gtg gta tat gac tgc ttc gag gct gcc cta ggg agt 714 Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 155 160 165 gag gta cga atc tgg tcc tat act cag ccc agg tac gag aag gaa ctc 762 Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 170 175 180 185 aac cac aca cag cag ctg cct gcc ctg ccc tgg ctc aac gtg tca gca 810 Asn His Thr Gln Gln Leu Pro Ala Leu Pro Trp Leu Asn Val Ser Ala 190 195 200 gat ggt gac aac gtg cat ctg gtt ctg aat gtc tct gag gag cag cac 858 Asp Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His 205 210 215 ttc ggc ctc tcc ctg tac tgg aat cag gtc cag ggc ccc cca aaa ccc 906 Phe Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro 220 225 230 cgg tgg cac aaa aac ctg gtg agg cct ccc cct tcc caa gtc cat tcc 954 Arg Trp His Lys Asn Leu Val Arg Pro Pro Pro Ser Gln Val His Ser 235 240 245 cac tgt agg ccg atg cct gtg caa agg acg cag tgc cat atc aga gag 1002 His Cys Arg Pro Met Pro Val Gln Arg Thr Gln Cys His Ile Arg Glu 250 255 260 265 gat cct tgaagaggac tcaccccaag caagggaaaa ttggtggggg aacttctgcc 1058 Asp Pro ttcctggttt ccttgacttt ggcctcctcc tcttcctcct tatcttctcc aacctccttc 1118 ctttatttgt tccacagact ggaccgcaga tcattacctt gaaccacaca gacctagttc 1178 cctgcctctg tattcaggtg tggcctctgg aacctgactc cgttaggacg aacatctgcc 1238 ccttcaggga ggacccccgc gcacaccaga acctctggca agccgcccga ctgcgactgc 1298 tgaccctgca gagctggctg ctggacgcac cgtgctcgct gcccgcagaa gcggcactgt 1358 gctggcgggc tccgggtggg gacccctgcc agccactggt cccaccgctt tcctgggaga 1418 acgtcactgt ggacaaggtt ctcgagttcc cattgctgaa aggccaccct aacctctgtg 1478 ttcaggtgaa cagctcggag aagctgcagc tgcaggagtg cttgtgggct gactccctgg 1538 ggcctctcaa agacgatgtg ctactgttgg agacacgagg cccccaggac aacagatccc 1598 tctgtgcctt ggaacccagt ggctgtactt cactacccag caaagcctcc acgctatggg 1658 acgatgactt gggagcgcta tgggcctgcc ccatggacaa atacatccac aagcgctggg 1718 ccctcgtgtg gctggcctgc ctactctttg ccgctgcgct ttccctcatc ctccttctca 1778 aaaaggatca cgcgaaaggg tggctgaggc tcttgaaaca ggacgtccgc tcgggggcgg 1838 ccgccagggg ccgcgcggct ctgctcctct actcagccga tgactcgggt ttcgagcgcc 1898 tggtgggcgc cctggcgtcg gccctgtgcc agctgccgct gcgcgtggcc gtagacctgt 1958 ggagccgtcg tgaactgagc gcgcaggggc ccgtggcttg gtttcacgcg cagcggcgcc 2018 agaccctgca ggagggcggc gtggtggtct tgctcttctc tcccggtgcg gtggcgctgt 2078 gcagcgagtg gctacaggat ggggtgtccg ggcccggggc gcacggcccg cacgacgcct 2138 tccgcgcctc gctcagctgc gtgctgcccg acttcttgca gggccgggcg cccggcagct 2198 acgtgggggc ctgcttcgac aggctgctcc acccggacgc cgtacccgcc cttttccgca 2258 ccgtgcccgt cttcacactg ccctcccaac tgccagactt cctgggggcc ctgcagcagc 2318 ctcgcgcccc gcgttccggg cggctccaag agagagcgga gcaagtgtcc cgggcccttc 2378 agccagccct ggatagctac ttccatcccc cggggactcc cgcgccggga cgcggggtgg 2438 gaccaggggc gggacctggg gcgggggacg ggacttaaat aaaggcagac gctgtttttc 2498 t 2499 <210> 264 <211> 267 <212> PRT <213> Homo sapiens <400> 264 Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 1 5 10 15 Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 20 25 30 Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 35 40 45 Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 50 55 60 His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 65 70 75 80 Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 85 90 95 Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 100 105 110 Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 115 120 125 Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 130 135 140 Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 145 150 155 160 Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 165 170 175 Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 180 185 190 Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu 195 200 205 Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp 210 215 220 Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Val 225 230 235 240 Arg Pro Pro Pro Ser Gln Val His Ser His Cys Arg Pro Met Pro Val 245 250 255 Gln Arg Thr Gln Cys His Ile Arg Glu Asp Pro 260 265 <210> 265 <211> 1601 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (9)..(641) <400> 265 tatccaga atg gtg ttt ctg aag ttc ttc tgc atg agt ttc ttc tgc cac 50 Met Val Phe Leu Lys Phe Phe Cys Met Ser Phe Phe Cys His 1 5 10 ctg tgt caa ggc tac ttc gat ggc ccc ctc tac cca gag atg tcc aat 98 Leu Cys Gln Gly Tyr Phe Asp Gly Pro Leu Tyr Pro Glu Met Ser Asn 15 20 25 30 ggg act ctg cac cac tac ttc gtg ccc gat ggg gac tat gag gag aac 146 Gly Thr Leu His His Tyr Phe Val Pro Asp Gly Asp Tyr Glu Glu Asn 35 40 45 gat gac ccc gag aag tgc cag ctg ctc ttc agg gtg agt gac cac agg 194 Asp Asp Pro Glu Lys Cys Gln Leu Leu Phe Arg Val Ser Asp His Arg 50 55 60 cgc tgc tcc cag ggg gag ggg agc cag gtt ggc agc ctg ctg agc ctc 242 Arg Cys Ser Gln Gly Glu Gly Ser Gln Val Gly Ser Leu Leu Ser Leu 65 70 75 acc ctg cgg gag gag ttc acc gtg ctg ggc cgc cag gtg gag gat gct 290 Thr Leu Arg Glu Glu Phe Thr Val Leu Gly Arg Gln Val Glu Asp Ala 80 85 90 ggg cgc gtg ctg gag ggc atc agc aaa agc atc tcc tac gac cta gac 338 Gly Arg Val Leu Glu Gly Ile Ser Lys Ser Ile Ser Tyr Asp Leu Asp 95 100 105 110 ggg gaa gag agc tat ggc aag tac ctg cgg cgg gag tcc cac cag atc 386 Gly Glu Glu Ser Tyr Gly Lys Tyr Leu Arg Arg Glu Ser His Gln Ile 115 120 125 ggg gat gcc tac tcc aac tcg gac aaa tcc ctc act gag ctg gag agc 434 Gly Asp Ala Tyr Ser Asn Ser Asp Lys Ser Leu Thr Glu Leu Glu Ser 130 135 140 aag ttc aag cag ggc cag gaa cag gac agc cgg cag gag agc agg ctc 482 Lys Phe Lys Gln Gly Gln Glu Gln Asp Ser Arg Gln Glu Ser Arg Leu 145 150 155 aac gag gac ttt ctg gga atg ctg gtc cac acc agg tcc ctg ctg aag 530 Asn Glu Asp Phe Leu Gly Met Leu Val His Thr Arg Ser Leu Leu Lys 160 165 170 gag aca ctg gac atc tct gtg ggg ctc agg gac aaa tac gag ctg ctg 578 Glu Thr Leu Asp Ile Ser Val Gly Leu Arg Asp Lys Tyr Glu Leu Leu 175 180 185 190 gcc ctc acc att agg agc cat ggg acc cga cta ggt cgg ctg aaa aat 626 Ala Leu Thr Ile Arg Ser His Gly Thr Arg Leu Gly Arg Leu Lys Asn 195 200 205 gat tat ctt aaa gta taggtggaag gatacaaatg ctagaaagag ggaatcaaat 681 Asp Tyr Leu Lys Val 210 cagccccgtt ttggagggtg ggggacagaa gatggggcta catttccccc atacctacta 741 tttttttata tcccgatttg cactttgaga atacatctaa ggtcatcttt caaaagagaa 801 aaattggaca cttgagtgac tttgttttta gttttgtttt tgtacattat ttatgtgatt 861 gttatggaat tgtcacctgg aaagaacaat tttaagcaat gtcatttcta gatgggtttc 921 taattctgca gagacacccg tttcagccac atctaaaaga gcacagttta tgtggtgcgg 981 aattaaactt ccccatcctg cagattatgt ggaaataccc aaagataata gtgcatagct 1041 cctttcagcc tctagccttc actcctgggc tccaaaagct atcccagttg cctgtttttc 1101 aaatgaggtt caaggtgctg ctttgcatgc ctgccaaccc atggaagttg tttcttactt 1161 cttttctctc ttatttatta accatggtct gagagttgtt tttgttctat gtaacagtat 1221 tgccacaaaa ctataggcaa atcgtgtttg cagggagatt tctgatgcct ctgtgggcgt 1281 gtgtaagtta aagtggccac atttaagaag gccaagcttt gtagtggttg cacagtcaca 1341 ctgatatgct gatttgctct ttctcattgt atgtctatgc tttgtcatca gtgctatagt 1401 aaattacaaa gaaataggta gattgtatga acatacccac aaatgcctat gatttaggtt 1461 accaatgtat tctttctcat ttggggtttt gcttctgtct gtctgtttat tggaagcttg 1521 tacttcaagt agggggaatc gtaattctaa taactcctta gctaagtttt attattcagg 1581 caataaacat gttttcatgt 1601 <210> 266 <211> 211 <212> PRT <213> Homo sapiens <400> 266 Met Val Phe Leu Lys Phe Phe Cys Met Ser Phe Phe Cys His Leu Cys 1 5 10 15 Gln Gly Tyr Phe Asp Gly Pro Leu Tyr Pro Glu Met Ser Asn Gly Thr 20 25 30 Leu His His Tyr Phe Val Pro Asp Gly Asp Tyr Glu Glu Asn Asp Asp 35 40 45 Pro Glu Lys Cys Gln Leu Leu Phe Arg Val Ser Asp His Arg Arg Cys 50 55 60 Ser Gln Gly Glu Gly Ser Gln Val Gly Ser Leu Leu Ser Leu Thr Leu 65 70 75 80 Arg Glu Glu Phe Thr Val Leu Gly Arg Gln Val Glu Asp Ala Gly Arg 85 90 95 Val Leu Glu Gly Ile Ser Lys Ser Ile Ser Tyr Asp Leu Asp Gly Glu 100 105 110 Glu Ser Tyr Gly Lys Tyr Leu Arg Arg Glu Ser His Gln Ile Gly Asp 115 120 125 Ala Tyr Ser Asn Ser Asp Lys Ser Leu Thr Glu Leu Glu Ser Lys Phe 130 135 140 Lys Gln Gly Gln Glu Gln Asp Ser Arg Gln Glu Ser Arg Leu Asn Glu 145 150 155 160 Asp Phe Leu Gly Met Leu Val His Thr Arg Ser Leu Leu Lys Glu Thr 165 170 175 Leu Asp Ile Ser Val Gly Leu Arg Asp Lys Tyr Glu Leu Leu Ala Leu 180 185 190 Thr Ile Arg Ser His Gly Thr Arg Leu Gly Arg Leu Lys Asn Asp Tyr 195 200 205 Leu Lys Val 210 <210> 267 <211> 1906 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (42)..(1628) <400> 267 gagcggggcc ggcagagcgc gcggcgtcgg tgcccttgac c atg gcg gcg gct gcg 56 Met Ala Ala Ala Ala 1 5 ctt ctg ctg ggg ctg gcg ctg ctg gca ccg cgg gcg gcc ggc gcg ggc 104 Leu Leu Leu Gly Leu Ala Leu Leu Ala Pro Arg Ala Ala Gly Ala Gly 10 15 20 atg ggc gcg tgc tat gac ggc gca ggg cgc ccg cag cgc tgc ctg ccg 152 Met Gly Ala Cys Tyr Asp Gly Ala Gly Arg Pro Gln Arg Cys Leu Pro 25 30 35 gtg ttc gag aac gcg gcg ttt ggg cgg ctc gcc cag gcc tcg cac acg 200 Val Phe Glu Asn Ala Ala Phe Gly Arg Leu Ala Gln Ala Ser His Thr 40 45 50 tgc ggc agc ccg ccc gag gac ttc tgt ccc cac gtg ggc gcc gcg ggc 248 Cys Gly Ser Pro Pro Glu Asp Phe Cys Pro His Val Gly Ala Ala Gly 55 60 65 gcg ggg gct cat tgc cag cgc tgc gac gcc gcc gac ccc cag cgc cac 296 Ala Gly Ala His Cys Gln Arg Cys Asp Ala Ala Asp Pro Gln Arg His 70 75 80 85 cac aac gcc tcc tac ctc acc gac ttc cac agc cag gac gag agc acc 344 His Asn Ala Ser Tyr Leu Thr Asp Phe His Ser Gln Asp Glu Ser Thr 90 95 100 tgg tgg cag agc ccg tcc atg gcc ttc ggc gtg cag tac ccc acc tcg 392 Trp Trp Gln Ser Pro Ser Met Ala Phe Gly Val Gln Tyr Pro Thr Ser 105 110 115 gtc aac atc acc ctc cgc cta ggg aag gct tat gag atc acg tat gtg 440 Val Asn Ile Thr Leu Arg Leu Gly Lys Ala Tyr Glu Ile Thr Tyr Val 120 125 130 agg ctg aag ttc cac acc agt cgc cct gag agc ttt gcc atc tac aag 488 Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe Ala Ile Tyr Lys 135 140 145 cgc agc cgc gcc gac ggc cca tgg gag ccc tac cag ttc tac agc gcc 536 Arg Ser Arg Ala Asp Gly Pro Trp Glu Pro Tyr Gln Phe Tyr Ser Ala 150 155 160 165 tcc tgc cag aag acc tac ggc cgg ccc gag ggc cag tgc ctg cgc ccc 584 Ser Cys Gln Lys Thr Tyr Gly Arg Pro Glu Gly Gln Cys Leu Arg Pro 170 175 180 ggc gag gac gag cgc gtg gcc ttc tgc acc tct gag ttc agc gac atc 632 Gly Glu Asp Glu Arg Val Ala Phe Cys Thr Ser Glu Phe Ser Asp Ile 185 190 195 tcc ccg ctg agt ggc ggc aac gtg gcc ttc tcc acc ctg gag ggc cgg 680 Ser Pro Leu Ser Gly Gly Asn Val Ala Phe Ser Thr Leu Glu Gly Arg 200 205 210 ccc agc gcc tac aac ttc gag gag agc cct ggg ctg cag gag tgg gtc 728 Pro Ser Ala Tyr Asn Phe Glu Glu Ser Pro Gly Leu Gln Glu Trp Val 215 220 225 acc agc acc gaa ctc ctc atc tct cta gac cgg ctc aac acg ttt ggg 776 Thr Ser Thr Glu Leu Leu Ile Ser Leu Asp Arg Leu Asn Thr Phe Gly 230 235 240 245 gac gac atc ttc aag gac ccc aag gtg ctc cag tcc tac tat tat gcc 824 Asp Asp Ile Phe Lys Asp Pro Lys Val Leu Gln Ser Tyr Tyr Tyr Ala 250 255 260 gtg tcc gac ttc tct gtg ggc ggc agg tgc aag tgc aac ggg cat gcc 872 Val Ser Asp Phe Ser Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala 265 270 275 agc gag tgc ggc ccc gac gtg gcg ggc cag ttg gcc tgc cgg tgc cag 920 Ser Glu Cys Gly Pro Asp Val Ala Gly Gln Leu Ala Cys Arg Cys Gln 280 285 290 cac aac acc acc ggc aca gac tgt gag cgc tgc ctg ccc ttc ttc cag 968 His Asn Thr Thr Gly Thr Asp Cys Glu Arg Cys Leu Pro Phe Phe Gln 295 300 305 gac cgc ccg tgg gcc cgg ggc acc gcc gag gct gct cac gag tgt ctg 1016 Asp Arg Pro Trp Ala Arg Gly Thr Ala Glu Ala Ala His Glu Cys Leu 310 315 320 325 ccc tgc aac tgc agt ggc cgc tcc gag gaa tgc acg ttt gat cgg gag 1064 Pro Cys Asn Cys Ser Gly Arg Ser Glu Glu Cys Thr Phe Asp Arg Glu 330 335 340 ctc ttc cgc agc aca ggc cac ggc ggg cgc tgt cac cac tgc cgt gac 1112 Leu Phe Arg Ser Thr Gly His Gly Gly Arg Cys His His Cys Arg Asp 345 350 355 cac aca gct ggg cca cac tgt gag cgc tgt cag gag aat ttc tat cac 1160 His Thr Ala Gly Pro His Cys Glu Arg Cys Gln Glu Asn Phe Tyr His 360 365 370 tgg gac ccg cgg atg cca tgc cag ccc tgt gac tgc cag tcg gca ggc 1208 Trp Asp Pro Arg Met Pro Cys Gln Pro Cys Asp Cys Gln Ser Ala Gly 375 380 385 tcc cta cac ctc cag tgc gat gac aca ggc acc tgc gcc tgc aag ccc 1256 Ser Leu His Leu Gln Cys Asp Asp Thr Gly Thr Cys Ala Cys Lys Pro 390 395 400 405 acg gtg act ggc tgg aag tgt gac cgc tgt ctg ccc ggg ttc cac tcg 1304 Thr Val Thr Gly Trp Lys Cys Asp Arg Cys Leu Pro Gly Phe His Ser 410 415 420 ctc agt gag gga ggc tgc aga ccc tgc act tgc aat ccc gct ggc agc 1352 Leu Ser Glu Gly Gly Cys Arg Pro Cys Thr Cys Asn Pro Ala Gly Ser 425 430 435 ctg gac acc tgt gac ccc cgc agt ggg cgc tgc ccc tgc aaa gag aat 1400 Leu Asp Thr Cys Asp Pro Arg Ser Gly Arg Cys Pro Cys Lys Glu Asn 440 445 450 gtg gaa ggc aac cta tgt gac aga tgt cgc ccg ggg acc ttt aac ctg 1448 Val Glu Gly Asn Leu Cys Asp Arg Cys Arg Pro Gly Thr Phe Asn Leu 455 460 465 cag ccc cac aat ccc agc agc agg agc tgc aga tcc agg gct tcg aga 1496 Gln Pro His Asn Pro Ser Ser Arg Ser Cys Arg Ser Arg Ala Ser Arg 470 475 480 485 gtg acc tcg ccg aga tcc gcg ccg aca aac aga acc tgg agg cca ttc 1544 Val Thr Ser Pro Arg Ser Ala Pro Thr Asn Arg Thr Trp Arg Pro Phe 490 495 500 tgc aca gcc tgc ccg aga act gtg cca gct ggc agt gag ggc tgc cca 1592 Cys Thr Ala Cys Pro Arg Thr Val Pro Ala Gly Ser Glu Gly Cys Pro 505 510 515 gat ccc cgg cac aca ctc ccc cac ctg ctg ttt aca tgacccaggg 1638 Asp Pro Arg His Thr Leu Pro His Leu Leu Phe Thr 520 525 ggtgcacact accccacagg tgtgcccata cagacattcc ccggagccgg ctgctgtgaa 1698 ctcgaccccg tgtggatagt cacactccct gccgattctg tctgtggctt cttccctgcc 1758 agcaggactg agtgtgcgta cccagttcac ctggacatga gtgcacactc tcacccctgc 1818 acatgcataa acgggcacac cccagtgtca ataacataca cacgtgaggg tgcatgtctg 1878 tgtgtatgac ccacacgtgt tcaagtct 1906 <210> 268 <211> 529 <212> PRT <213> Homo sapiens <400> 268 Met Ala Ala Ala Ala Leu Leu Leu Gly Leu Ala Leu Leu Ala Pro Arg 1 5 10 15 Ala Ala Gly Ala Gly Met Gly Ala Cys Tyr Asp Gly Ala Gly Arg Pro 20 25 30 Gln Arg Cys Leu Pro Val Phe Glu Asn Ala Ala Phe Gly Arg Leu Ala 35 40 45 Gln Ala Ser His Thr Cys Gly Ser Pro Pro Glu Asp Phe Cys Pro His 50 55 60 Val Gly Ala Ala Gly Ala Gly Ala His Cys Gln Arg Cys Asp Ala Ala 65 70 75 80 Asp Pro Gln Arg His His Asn Ala Ser Tyr Leu Thr Asp Phe His Ser 85 90 95 Gln Asp Glu Ser Thr Trp Trp Gln Ser Pro Ser Met Ala Phe Gly Val 100 105 110 Gln Tyr Pro Thr Ser Val Asn Ile Thr Leu Arg Leu Gly Lys Ala Tyr 115 120 125 Glu Ile Thr Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser 130 135 140 Phe Ala Ile Tyr Lys Arg Ser Arg Ala Asp Gly Pro Trp Glu Pro Tyr 145 150 155 160 Gln Phe Tyr Ser Ala Ser Cys Gln Lys Thr Tyr Gly Arg Pro Glu Gly 165 170 175 Gln Cys Leu Arg Pro Gly Glu Asp Glu Arg Val Ala Phe Cys Thr Ser 180 185 190 Glu Phe Ser Asp Ile Ser Pro Leu Ser Gly Gly Asn Val Ala Phe Ser 195 200 205 Thr Leu Glu Gly Arg Pro Ser Ala Tyr Asn Phe Glu Glu Ser Pro Gly 210 215 220 Leu Gln Glu Trp Val Thr Ser Thr Glu Leu Leu Ile Ser Leu Asp Arg 225 230 235 240 Leu Asn Thr Phe Gly Asp Asp Ile Phe Lys Asp Pro Lys Val Leu Gln 245 250 255 Ser Tyr Tyr Tyr Ala Val Ser Asp Phe Ser Val Gly Gly Arg Cys Lys 260 265 270 Cys Asn Gly His Ala Ser Glu Cys Gly Pro Asp Val Ala Gly Gln Leu 275 280 285 Ala Cys Arg Cys Gln His Asn Thr Thr Gly Thr Asp Cys Glu Arg Cys 290 295 300 Leu Pro Phe Phe Gln Asp Arg Pro Trp Ala Arg Gly Thr Ala Glu Ala 305 310 315 320 Ala His Glu Cys Leu Pro Cys Asn Cys Ser Gly Arg Ser Glu Glu Cys 325 330 335 Thr Phe Asp Arg Glu Leu Phe Arg Ser Thr Gly His Gly Gly Arg Cys 340 345 350 His His Cys Arg Asp His Thr Ala Gly Pro His Cys Glu Arg Cys Gln 355 360 365 Glu Asn Phe Tyr His Trp Asp Pro Arg Met Pro Cys Gln Pro Cys Asp 370 375 380 Cys Gln Ser Ala Gly Ser Leu His Leu Gln Cys Asp Asp Thr Gly Thr 385 390 395 400 Cys Ala Cys Lys Pro Thr Val Thr Gly Trp Lys Cys Asp Arg Cys Leu 405 410 415 Pro Gly Phe His Ser Leu Ser Glu Gly Gly Cys Arg Pro Cys Thr Cys 420 425 430 Asn Pro Ala Gly Ser Leu Asp Thr Cys Asp Pro Arg Ser Gly Arg Cys 435 440 445 Pro Cys Lys Glu Asn Val Glu Gly Asn Leu Cys Asp Arg Cys Arg Pro 450 455 460 Gly Thr Phe Asn Leu Gln Pro His Asn Pro Ser Ser Arg Ser Cys Arg 465 470 475 480 Ser Arg Ala Ser Arg Val Thr Ser Pro Arg Ser Ala Pro Thr Asn Arg 485 490 495 Thr Trp Arg Pro Phe Cys Thr Ala Cys Pro Arg Thr Val Pro Ala Gly 500 505 510 Ser Glu Gly Cys Pro Asp Pro Arg His Thr Leu Pro His Leu Leu Phe 515 520 525 Thr <210> 269 <211> 1638 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (380)..(1138) <400> 269 agatcgcgcc aggagaggag gagagctcgg gcgagcggcg agcacaggcc acgggagctg 60 agcgcagcag agagcagccg gagtccgcgc ctgactccgc gcgggtcctg agccggccgc 120 agcttgccag gatccccggc gtccttctcg cgccgcttca cgaagagggc gccttcgccg 180 ctcgcccagc cggagtgcgc acgggcccgc tggaaaccgc actcgccgct ccctgggcag 240 gccggggcac ccgggcacgc agggcgcgcc tggcgagcgc cccgggaggc ggcgtgcagg 300 accagcggcg gccgtgcagg cggaggactt cggcgcggct cctcctgggt gtgaccccgg 360 gcgcgcccgc cgcgcgacg atg agg gcg cgg ccg cag gtc tgc gag gcg ctg 412 Met Arg Ala Arg Pro Gln Val Cys Glu Ala Leu 1 5 10 ctc ttc gcc ctg gcg ctc cag acc ggc gtg tgc tat ggc atc aag tgg 460 Leu Phe Ala Leu Ala Leu Gln Thr Gly Val Cys Tyr Gly Ile Lys Trp 15 20 25 ctg gcg ctg tcc aag aca cca tcg gcc ctg gca ctg aac cag acg caa 508 Leu Ala Leu Ser Lys Thr Pro Ser Ala Leu Ala Leu Asn Gln Thr Gln 30 35 40 cac tgc aag cag ctg gag ggt ctg gtg tct gca cag gtg cag ctg tgc 556 His Cys Lys Gln Leu Glu Gly Leu Val Ser Ala Gln Val Gln Leu Cys 45 50 55 cgc agc aac ctg gag ctc atg cac acg gtg gtg cac gcc gcc cgc gag 604 Arg Ser Asn Leu Glu Leu Met His Thr Val Val His Ala Ala Arg Glu 60 65 70 75 gtc atg aag gcc tgt cgc cgg gcc ttt gcc gac atg cgc tgg aac tgc 652 Val Met Lys Ala Cys Arg Arg Ala Phe Ala Asp Met Arg Trp Asn Cys 80 85 90 tcc tcc att gag ctc gcc ccc aac tat ttg ctt gac ctg gag aga ggg 700 Ser Ser Ile Glu Leu Ala Pro Asn Tyr Leu Leu Asp Leu Glu Arg Gly 95 100 105 acc cgg gag tcg gcc ttc gtg tat gcg ctg tcg gcc gcc gcc atc agc 748 Thr Arg Glu Ser Ala Phe Val Tyr Ala Leu Ser Ala Ala Ala Ile Ser 110 115 120 cac gcc atc gcc cgg gcc tgc acc tcc ggc gac ctg ccc ggc tgc tcc 796 His Ala Ile Ala Arg Ala Cys Thr Ser Gly Asp Leu Pro Gly Cys Ser 125 130 135 tgc ggc ccc gtc cca ggt gag cca ccc ggg ccc ggg aac cgc tgg gga 844 Cys Gly Pro Val Pro Gly Glu Pro Pro Gly Pro Gly Asn Arg Trp Gly 140 145 150 155 gga tgt gcg gac aac ctc agc tac ggg ctc ctc atg ggg gcc aag ttt 892 Gly Cys Ala Asp Asn Leu Ser Tyr Gly Leu Leu Met Gly Ala Lys Phe 160 165 170 tcc gat gct cct atg aag gtg aaa aaa aca gga tcc caa gcc aat aaa 940 Ser Asp Ala Pro Met Lys Val Lys Lys Thr Gly Ser Gln Ala Asn Lys 175 180 185 ctg atg cgt cta cac aac agt gaa gtg ggg aga cag gct ctg cgc gcc 988 Leu Met Arg Leu His Asn Ser Glu Val Gly Arg Gln Ala Leu Arg Ala 190 195 200 tct ctg ctt gtg aat tcc aga tgc cag gca tgg gag gcg gct tgt gct 1036 Ser Leu Leu Val Asn Ser Arg Cys Gln Ala Trp Glu Ala Ala Cys Ala 205 210 215 ttg cct tca ctt gga agc cac cag gaa cag aag gtc tgg cca ccc tgg 1084 Leu Pro Ser Leu Gly Ser His Gln Glu Gln Lys Val Trp Pro Pro Trp 220 225 230 235 aag gag ggc agg aca tca aag gaa acc gac aag att aaa aat aac ttg 1132 Lys Glu Gly Arg Thr Ser Lys Glu Thr Asp Lys Ile Lys Asn Asn Leu 240 245 250 gca gcc tgaggctctg gagtgcccac aggctggtgt aaggagcggg gcttgggatc 1188 Ala Ala ggtgagactg atacagactt gacctttcag ggccacagag accagcctcc gggaaggggt 1248 ctgcccgcct tcttcagaat gttctgcggg accccctggc ccaccctggg gtctgagcct 1308 gctgggccca ccacatggaa tcactagctt gggttgtaaa tgttttcttt tgttttttgc 1368 tttttcttcc tttgggatgt ggaagctaca gaaatattta taaaacatag ctttttcttt 1428 ggggtggcac ttctcaattc ctctttatat attttatata tataaatata tatgtatata 1488 tataatgatc tctattttaa aactagcttt ttaagcagct gtatgaaata aatgctgagt 1548 gagccccagc ccgcccctgc agttcccggc ctcgtcaagt gaactcggca gaccctgggg 1608 ctggcagagg gagctctcca gtttccaggc 1638 <210> 270 <211> 253 <212> PRT <213> Homo sapiens <400> 270 Met Arg Ala Arg Pro Gln Val Cys Glu Ala Leu Leu Phe Ala Leu Ala 1 5 10 15 Leu Gln Thr Gly Val Cys Tyr Gly Ile Lys Trp Leu Ala Leu Ser Lys 20 25 30 Thr Pro Ser Ala Leu Ala Leu Asn Gln Thr Gln His Cys Lys Gln Leu 35 40 45 Glu Gly Leu Val Ser Ala Gln Val Gln Leu Cys Arg Ser Asn Leu Glu 50 55 60 Leu Met His Thr Val Val His Ala Ala Arg Glu Val Met Lys Ala Cys 65 70 75 80 Arg Arg Ala Phe Ala Asp Met Arg Trp Asn Cys Ser Ser Ile Glu Leu 85 90 95 Ala Pro Asn Tyr Leu Leu Asp Leu Glu Arg Gly Thr Arg Glu Ser Ala 100 105 110 Phe Val Tyr Ala Leu Ser Ala Ala Ala Ile Ser His Ala Ile Ala Arg 115 120 125 Ala Cys Thr Ser Gly Asp Leu Pro Gly Cys Ser Cys Gly Pro Val Pro 130 135 140 Gly Glu Pro Pro Gly Pro Gly Asn Arg Trp Gly Gly Cys Ala Asp Asn 145 150 155 160 Leu Ser Tyr Gly Leu Leu Met Gly Ala Lys Phe Ser Asp Ala Pro Met 165 170 175 Lys Val Lys Lys Thr Gly Ser Gln Ala Asn Lys Leu Met Arg Leu His 180 185 190 Asn Ser Glu Val Gly Arg Gln Ala Leu Arg Ala Ser Leu Leu Val Asn 195 200 205 Ser Arg Cys Gln Ala Trp Glu Ala Ala Cys Ala Leu Pro Ser Leu Gly 210 215 220 Ser His Gln Glu Gln Lys Val Trp Pro Pro Trp Lys Glu Gly Arg Thr 225 230 235 240 Ser Lys Glu Thr Asp Lys Ile Lys Asn Asn Leu Ala Ala 245 250 <210> 271 <211> 3593 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (13)..(1878) <400> 271 acgcgtggcg cg atg gcg gcg gcc cca cgc gcg ggc cgg cgg cgc ggg cag 51 Met Ala Ala Ala Pro Arg Ala Gly Arg Arg Arg Gly Gln 1 5 10 ccg ctc ctg gcg ctg ctg ctt ctg ctg ctg gcg cca ctg ccg ccg ggg 99 Pro Leu Leu Ala Leu Leu Leu Leu Leu Leu Ala Pro Leu Pro Pro Gly 15 20 25 gcc ccg ccg ggc gcc gac gcc tac ttt ccc gag gag cgc tgg agc ccg 147 Ala Pro Pro Gly Ala Asp Ala Tyr Phe Pro Glu Glu Arg Trp Ser Pro 30 35 40 45 gag tcg ccc ctg cag gcg ccg cgc gtg ctc atc gcg ctg ttg gcg cga 195 Glu Ser Pro Leu Gln Ala Pro Arg Val Leu Ile Ala Leu Leu Ala Arg 50 55 60 aac gcg gcc cac gcg ttg ccc acc acg ctg ggc gca ctc gag cgg ctg 243 Asn Ala Ala His Ala Leu Pro Thr Thr Leu Gly Ala Leu Glu Arg Leu 65 70 75 cgg cac ccg cgg gag cgc acg gcg cta tgg gtg gct acg gac cac aac 291 Arg His Pro Arg Glu Arg Thr Ala Leu Trp Val Ala Thr Asp His Asn 80 85 90 atg gat aac acg tca act gtg ctg cgg gag tgg ctg gtg gcc gtg aag 339 Met Asp Asn Thr Ser Thr Val Leu Arg Glu Trp Leu Val Ala Val Lys 95 100 105 agt ttg tac cat tcc gtg gag tgg cgg cca gca gag gag ccc agg tcc 387 Ser Leu Tyr His Ser Val Glu Trp Arg Pro Ala Glu Glu Pro Arg Ser 110 115 120 125 tac ccg gac gag gaa ggc ccg aaa cac tgg tct gac tca cgc tac gag 435 Tyr Pro Asp Glu Glu Gly Pro Lys His Trp Ser Asp Ser Arg Tyr Glu 130 135 140 cat gtc atg aag ttg cgc cag gca gcc ctg aaa tca gct cga gac atg 483 His Val Met Lys Leu Arg Gln Ala Ala Leu Lys Ser Ala Arg Asp Met 145 150 155 tgg gct gat tac atc ctg ttt gta gat gcg gac aac ctg atc ctc aac 531 Trp Ala Asp Tyr Ile Leu Phe Val Asp Ala Asp Asn Leu Ile Leu Asn 160 165 170 cct gac aca ctg agc ctg ctc atc gct gag aac aag acg gtg gtc gcc 579 Pro Asp Thr Leu Ser Leu Leu Ile Ala Glu Asn Lys Thr Val Val Ala 175 180 185 ccc atg ctg gat tcc cgg gct gcg tac tcc aac ttc tgg tgt gga atg 627 Pro Met Leu Asp Ser Arg Ala Ala Tyr Ser Asn Phe Trp Cys Gly Met 190 195 200 205 act tcc cag ggc tac tac aag cgc aca cct gcc tac atc cct atc cgc 675 Thr Ser Gln Gly Tyr Tyr Lys Arg Thr Pro Ala Tyr Ile Pro Ile Arg 210 215 220 aag cga gac cgc cgg ggc tgc ttt gca gtt ccc atg gtg cac tcg acc 723 Lys Arg Asp Arg Arg Gly Cys Phe Ala Val Pro Met Val His Ser Thr 225 230 235 ttc ctg atc gac ctg cgg aag gcg gcg tcc agg aac ctg gcc ttc tac 771 Phe Leu Ile Asp Leu Arg Lys Ala Ala Ser Arg Asn Leu Ala Phe Tyr 240 245 250 cca cct cac cct gac tac acc tgg tcc ttt gac gac atc atc gtc ttt 819 Pro Pro His Pro Asp Tyr Thr Trp Ser Phe Asp Asp Ile Ile Val Phe 255 260 265 gcc ttc tcc tgc aag cag gca gag gtt cag atg tat gtg tgc aac aag 867 Ala Phe Ser Cys Lys Gln Ala Glu Val Gln Met Tyr Val Cys Asn Lys 270 275 280 285 gag gag tac gga ttc ttg cca gtg cca ttg cgc gcc cac agc acc ctc 915 Glu Glu Tyr Gly Phe Leu Pro Val Pro Leu Arg Ala His Ser Thr Leu 290 295 300 cag gat gag gcc gag agc ttc atg cat gtg cag ctg gag gtc atg gtg 963 Gln Asp Glu Ala Glu Ser Phe Met His Val Gln Leu Glu Val Met Val 305 310 315 aag cac ccg ccc gca gag ccc tcc cgc ttc atc tcg gct ccc acc aag 1011 Lys His Pro Pro Ala Glu Pro Ser Arg Phe Ile Ser Ala Pro Thr Lys 320 325 330 aca ccg gac aag atg ggc ttc gac gag gtc ttc atg atc aac ctg agg 1059 Thr Pro Asp Lys Met Gly Phe Asp Glu Val Phe Met Ile Asn Leu Arg 335 340 345 cgg cgg cag gac cgg cgg gag cgc atg ctg cgg gcg ctg cag gca cag 1107 Arg Arg Gln Asp Arg Arg Glu Arg Met Leu Arg Ala Leu Gln Ala Gln 350 355 360 365 gag atc gag tgc cgg ctg gtg gag gcc gtg gac ggc aaa gcc atg aac 1155 Glu Ile Glu Cys Arg Leu Val Glu Ala Val Asp Gly Lys Ala Met Asn 370 375 380 acc agc cag gtg gag gcg ctg ggg atc cag atg ctg cct ggc tac cgg 1203 Thr Ser Gln Val Glu Ala Leu Gly Ile Gln Met Leu Pro Gly Tyr Arg 385 390 395 gac ccc tac cac ggc cgg ccc ctc acc aag ggt gag ctg ggc tgc ttc 1251 Asp Pro Tyr His Gly Arg Pro Leu Thr Lys Gly Glu Leu Gly Cys Phe 400 405 410 ctg agc cac tac aac atc tgg aag gag gtg gtg gac cgg ggg ctg cag 1299 Leu Ser His Tyr Asn Ile Trp Lys Glu Val Val Asp Arg Gly Leu Gln 415 420 425 aaa tcg ctt gtg ttt gag gat gac ctg cgt ttt gag atc ttc ttc aag 1347 Lys Ser Leu Val Phe Glu Asp Asp Leu Arg Phe Glu Ile Phe Phe Lys 430 435 440 445 aga cgt ctg atg aac ctc atg cgg gat gtg gag cgg gag ggc ctg gac 1395 Arg Arg Leu Met Asn Leu Met Arg Asp Val Glu Arg Glu Gly Leu Asp 450 455 460 tgg gac ctc atc tat gtg ggc cgg aag cgg atg cag gtg gag cac ccc 1443 Trp Asp Leu Ile Tyr Val Gly Arg Lys Arg Met Gln Val Glu His Pro 465 470 475 gag aag gct gtg cct cgc gtg agg aac ctg gtg gag gcc gac tat tcc 1491 Glu Lys Ala Val Pro Arg Val Arg Asn Leu Val Glu Ala Asp Tyr Ser 480 485 490 tac tgg acc ctg gcc tac gtg atc tcc ctg caa ggc gcc cgc aaa ctg 1539 Tyr Trp Thr Leu Ala Tyr Val Ile Ser Leu Gln Gly Ala Arg Lys Leu 495 500 505 ctg gct gct gag ccg ctc tcc aag atg ctg cct gtg gac gag ttc ctg 1587 Leu Ala Ala Glu Pro Leu Ser Lys Met Leu Pro Val Asp Glu Phe Leu 510 515 520 525 ccc gtc atg ttc gac aaa cac cca gtg tcc gag tac aag gcc cac ttc 1635 Pro Val Met Phe Asp Lys His Pro Val Ser Glu Tyr Lys Ala His Phe 530 535 540 tcc ctc cgc aac ctg cat gcc ttc tct gtg gag ccg ctg ctc atc tac 1683 Ser Leu Arg Asn Leu His Ala Phe Ser Val Glu Pro Leu Leu Ile Tyr 545 550 555 ccc aca cac tac aca gga gac gat ggc tat gtg agt gac acc gag acc 1731 Pro Thr His Tyr Thr Gly Asp Asp Gly Tyr Val Ser Asp Thr Glu Thr 560 565 570 tca gtc gta tgg aac aat gag cac gtc aag acc gac tgg gac cgc gcc 1779 Ser Val Val Trp Asn Asn Glu His Val Lys Thr Asp Trp Asp Arg Ala 575 580 585 aag tcc cag aag atg cgg gag cag cag gca ctg agc cgt gag gcc aag 1827 Lys Ser Gln Lys Met Arg Glu Gln Gln Ala Leu Ser Arg Glu Ala Lys 590 595 600 605 aac tcg gac gtg ctc cag tcc cca ctg gac agt gct gcc cgg gat gaa 1875 Asn Ser Asp Val Leu Gln Ser Pro Leu Asp Ser Ala Ala Arg Asp Glu 610 615 620 ctc tgaggggtag cagccagaaa gccaaagcag ccatcggtgg cccaggctcc 1928 Leu acgtgcttac tgaggacatc agggccacct ctggacccct tggcaggcca cagagggctc 1988 tcgtgtgggg tggtgtccag ccagctcttg ctaagcaatc acgtgcacac aggcagcatt 2048 aatggagtgc ctactgcatg ccagcaacag ggcttggccc tggggaattg ggaggaacca 2108 agccctcttc atctgttcat gtgcccagca tttattaagc acctgctgta tgcaaggttc 2168 ccatgttacg gcagtgaatg aggcataatt gttccctcca tcagcgattg attcagtcat 2228 caagcagtta ctgatcagat taagaatcag gcactagtga tacacattca tttttaaaat 2288 tcattcaagg atttattgag tgcctactgt gtgttgggtg ccattccagg ctctgggatt 2348 tttttttttt tttttttaag agtagagtct gtctctgtca cccaggctgg agtgcagtgg 2408 tgtgacggct cactgcagcc tgcgcctccc agcgtccagc aattcttgtt tctcggcctc 2468 ccaagtagct gggactatag gtgcgtgcca tcacatctgg ctagtttttg tatttttagt 2528 agagacgggg tttcaccatg ttggccagac tggtctcgaa ctcctgacct caagtgatct 2588 gcccgccttg gccacccaaa gtgctagggt tacaggcatg agccactgtg cccagcccag 2648 gctctgggaa tattgagata aataagatgc ttctatccat ttattcaagc acatattggt 2708 cacctactgt gtgcctggca ctcatgtcac aaagataagt tcctgattcg gtacacttac 2768 tgagcacctg ctgtgtgcag ggagctgagc tatgggatgg gaatgggagt aaacaaggta 2828 cttttcactt ttttcttttt ttcctcactg ctagacggtg tgggaacttc tcactcattg 2888 gcttctttcc cacacacctg aagagcactg actgtgtgcc gggcactagt gatacaaaag 2948 agtgtgacag ttgttcagtc tgcattttcg atcatgggct acatgccgag tgctggggca 3008 cagagatgaa caagatcggt tccttcactt cttcatgcca caagtgttta ttgagcacct 3068 gtgtgccagg cctcacagac tcccagttgg gttgaagaat ggttgactga gtttgattct 3128 tcctgtaccc tcggtcgtct gagctgtgtg cggacaacat ccccccacca cccaagaggg 3188 agggtagctc ttccgccacc aggggcaagc acaggtcctg gtggccccac gccacatgtt 3248 agcccccctg gagggggcgc cagttggaga cgggggctgg gtgtccctgg cccactccca 3308 gtcccctgtg ctttacctcc ttgcccttgt gtctcaggtg tggtccctgc ctgcttgatg 3368 aagttgctct gttcaagcct ttggtgggat catgtgtttg ggggctttta ggggacccag 3428 ctgcactggg gcactgcccg tggcctgggt aggacatttc ccagcaaggg ctggaggagt 3488 tgccgtgcct tcagcctgaa tcgaatgtca gaaccagcca gcggtgcttc accctcttgg 3548 ggataacttg cttagttttt taataaatgt tcctggttgg ttttc 3593 <210> 272 <211> 622 <212> PRT <213> Homo sapiens <400> 272 Met Ala Ala Ala Pro Arg Ala Gly Arg Arg Arg Gly Gln Pro Leu Leu 1 5 10 15 Ala Leu Leu Leu Leu Leu Leu Ala Pro Leu Pro Pro Gly Ala Pro Pro 20 25 30 Gly Ala Asp Ala Tyr Phe Pro Glu Glu Arg Trp Ser Pro Glu Ser Pro 35 40 45 Leu Gln Ala Pro Arg Val Leu Ile Ala Leu Leu Ala Arg Asn Ala Ala 50 55 60 His Ala Leu Pro Thr Thr Leu Gly Ala Leu Glu Arg Leu Arg His Pro 65 70 75 80 Arg Glu Arg Thr Ala Leu Trp Val Ala Thr Asp His Asn Met Asp Asn 85 90 95 Thr Ser Thr Val Leu Arg Glu Trp Leu Val Ala Val Lys Ser Leu Tyr 100 105 110 His Ser Val Glu Trp Arg Pro Ala Glu Glu Pro Arg Ser Tyr Pro Asp 115 120 125 Glu Glu Gly Pro Lys His Trp Ser Asp Ser Arg Tyr Glu His Val Met 130 135 140 Lys Leu Arg Gln Ala Ala Leu Lys Ser Ala Arg Asp Met Trp Ala Asp 145 150 155 160 Tyr Ile Leu Phe Val Asp Ala Asp Asn Leu Ile Leu Asn Pro Asp Thr 165 170 175 Leu Ser Leu Leu Ile Ala Glu Asn Lys Thr Val Val Ala Pro Met Leu 180 185 190 Asp Ser Arg Ala Ala Tyr Ser Asn Phe Trp Cys Gly Met Thr Ser Gln 195 200 205 Gly Tyr Tyr Lys Arg Thr Pro Ala Tyr Ile Pro Ile Arg Lys Arg Asp 210 215 220 Arg Arg Gly Cys Phe Ala Val Pro Met Val His Ser Thr Phe Leu Ile 225 230 235 240 Asp Leu Arg Lys Ala Ala Ser Arg Asn Leu Ala Phe Tyr Pro Pro His 245 250 255 Pro Asp Tyr Thr Trp Ser Phe Asp Asp Ile Ile Val Phe Ala Phe Ser 260 265 270 Cys Lys Gln Ala Glu Val Gln Met Tyr Val Cys Asn Lys Glu Glu Tyr 275 280 285 Gly Phe Leu Pro Val Pro Leu Arg Ala His Ser Thr Leu Gln Asp Glu 290 295 300 Ala Glu Ser Phe Met His Val Gln Leu Glu Val Met Val Lys His Pro 305 310 315 320 Pro Ala Glu Pro Ser Arg Phe Ile Ser Ala Pro Thr Lys Thr Pro Asp 325 330 335 Lys Met Gly Phe Asp Glu Val Phe Met Ile Asn Leu Arg Arg Arg Gln 340 345 350 Asp Arg Arg Glu Arg Met Leu Arg Ala Leu Gln Ala Gln Glu Ile Glu 355 360 365 Cys Arg Leu Val Glu Ala Val Asp Gly Lys Ala Met Asn Thr Ser Gln 370 375 380 Val Glu Ala Leu Gly Ile Gln Met Leu Pro Gly Tyr Arg Asp Pro Tyr 385 390 395 400 His Gly Arg Pro Leu Thr Lys Gly Glu Leu Gly Cys Phe Leu Ser His 405 410 415 Tyr Asn Ile Trp Lys Glu Val Val Asp Arg Gly Leu Gln Lys Ser Leu 420 425 430 Val Phe Glu Asp Asp Leu Arg Phe Glu Ile Phe Phe Lys Arg Arg Leu 435 440 445 Met Asn Leu Met Arg Asp Val Glu Arg Glu Gly Leu Asp Trp Asp Leu 450 455 460 Ile Tyr Val Gly Arg Lys Arg Met Gln Val Glu His Pro Glu Lys Ala 465 470 475 480 Val Pro Arg Val Arg Asn Leu Val Glu Ala Asp Tyr Ser Tyr Trp Thr 485 490 495 Leu Ala Tyr Val Ile Ser Leu Gln Gly Ala Arg Lys Leu Leu Ala Ala 500 505 510 Glu Pro Leu Ser Lys Met Leu Pro Val Asp Glu Phe Leu Pro Val Met 515 520 525 Phe Asp Lys His Pro Val Ser Glu Tyr Lys Ala His Phe Ser Leu Arg 530 535 540 Asn Leu His Ala Phe Ser Val Glu Pro Leu Leu Ile Tyr Pro Thr His 545 550 555 560 Tyr Thr Gly Asp Asp Gly Tyr Val Ser Asp Thr Glu Thr Ser Val Val 565 570 575 Trp Asn Asn Glu His Val Lys Thr Asp Trp Asp Arg Ala Lys Ser Gln 580 585 590 Lys Met Arg Glu Gln Gln Ala Leu Ser Arg Glu Ala Lys Asn Ser Asp 595 600 605 Val Leu Gln Ser Pro Leu Asp Ser Ala Ala Arg Asp Glu Leu 610 615 620 <210> 273 <211> 2835 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (160)..(2388) <400> 273 aagcctccca ttacggagca cgagagagtc catgaaggtc cccgcgactc ccggactgga 60 gaaaacggct cttgcgatgg ggcgaagtcc gagctgcggc gggcgttggt ccgtgcaggg 120 aagtgggaat cgttaggttc gttctggacc cgccgcccc atg gcc cag gcg tct 174 Met Ala Gln Ala Ser 1 5 cgc tca ggt agc ctg cct cca ctc gtt atc gtg ccc ccg ctg agg gcg 222 Arg Ser Gly Ser Leu Pro Pro Leu Val Ile Val Pro Pro Leu Arg Ala 10 15 20 caa ccc ggg ggc act ggg gag gag cag tgg gag aga agt cga acg ggc 270 Gln Pro Gly Gly Thr Gly Glu Glu Gln Trp Glu Arg Ser Arg Thr Gly 25 30 35 ggt ctt cgc tgg gag gtt cac tgc tgg ccg agc gga act tct gga ggg 318 Gly Leu Arg Trp Glu Val His Cys Trp Pro Ser Gly Thr Ser Gly Gly 40 45 50 acg ccg tgg tgg ccg acg ccg gcg gat gtg agc gag gac tac gag gct 366 Thr Pro Trp Trp Pro Thr Pro Ala Asp Val Ser Glu Asp Tyr Glu Ala 55 60 65 gat gct gcg gcc tgg agg cgg ggg ccc gca ggt ggc ggc ccg atc cct 414 Asp Ala Ala Ala Trp Arg Arg Gly Pro Ala Gly Gly Gly Pro Ile Pro 70 75 80 85 ccc gcg ctg cag cgt ctc cgg gcg gtg ttg ctg cgg ctg cat cgc gag 462 Pro Ala Leu Gln Arg Leu Arg Ala Val Leu Leu Arg Leu His Arg Glu 90 95 100 cgg gag cag ctc ctc cag gcc cga gac tgc gcc tac cac cta cag tcg 510 Arg Glu Gln Leu Leu Gln Ala Arg Asp Cys Ala Tyr His Leu Gln Ser 105 110 115 gct gtg cga ctc atg aag acc ctg agt cct ggc tcg cca tcc ggc ggc 558 Ala Val Arg Leu Met Lys Thr Leu Ser Pro Gly Ser Pro Ser Gly Gly 120 125 130 cct agc ccc ttg ccc cag tgg tac cgc gac ctg cag ctg cac cct tcc 606 Pro Ser Pro Leu Pro Gln Trp Tyr Arg Asp Leu Gln Leu His Pro Ser 135 140 145 caa ggg gcg gtt ctg cga atc ggc cct ggg gag act ctc gag ccg ctg 654 Gln Gly Ala Val Leu Arg Ile Gly Pro Gly Glu Thr Leu Glu Pro Leu 150 155 160 165 ctg cta gcg cgc ccc atc gga cta gcc gcc cag tgc ctg gag gct gtc 702 Leu Leu Ala Arg Pro Ile Gly Leu Ala Ala Gln Cys Leu Glu Ala Val 170 175 180 atc gag atg cag ctt cgc gct ctc ggc cgg gag ccc gcc agc ccg ggc 750 Ile Glu Met Gln Leu Arg Ala Leu Gly Arg Glu Pro Ala Ser Pro Gly 185 190 195 ctg tcg tcc caa ctc gcc gag ctg ctc ttt gca ctt ccc gcc tac cac 798 Leu Ser Ser Gln Leu Ala Glu Leu Leu Phe Ala Leu Pro Ala Tyr His 200 205 210 aca cta cag aga aaa gcc ttg agc cac gtc cca ggg gcc gca cgt cct 846 Thr Leu Gln Arg Lys Ala Leu Ser His Val Pro Gly Ala Ala Arg Pro 215 220 225 ttc ccc acg tcc cgt gtg ctc cgc ctc ttg acg ggg gag cgg ggt tgc 894 Phe Pro Thr Ser Arg Val Leu Arg Leu Leu Thr Gly Glu Arg Gly Cys 230 235 240 245 cag gtg gca agt cgg ctg gac gag gcg ctc caa gga tcg gcg ttg agg 942 Gln Val Ala Ser Arg Leu Asp Glu Ala Leu Gln Gly Ser Ala Leu Arg 250 255 260 gac cag ctc cgc agg cgg tgc caa gag gag ggg gat ctg cta cca ggg 990 Asp Gln Leu Arg Arg Arg Cys Gln Glu Glu Gly Asp Leu Leu Pro Gly 265 270 275 ctg ctg ggc ctg gtc ggg ggc gtg gcg ggt tca gcc agc tgt gga cta 1038 Leu Leu Gly Leu Val Gly Gly Val Ala Gly Ser Ala Ser Cys Gly Leu 280 285 290 ggg ctc gga ggg gct ggg gcc ttg tgg tgc caa tac tgg acc ctg ctg 1086 Gly Leu Gly Gly Ala Gly Ala Leu Trp Cys Gln Tyr Trp Thr Leu Leu 295 300 305 tgg gca gcc tgt gct cag agt ctg gac cta aat ctg gga ccc tgg agg 1134 Trp Ala Ala Cys Ala Gln Ser Leu Asp Leu Asn Leu Gly Pro Trp Arg 310 315 320 325 gac ccc agg gca aca gcg caa cag ctg agt cag gca ctg ggt cag gca 1182 Asp Pro Arg Ala Thr Ala Gln Gln Leu Ser Gln Ala Leu Gly Gln Ala 330 335 340 tcc ctg cct cag gag tgt gag aag gag ctg gca tct ttg tgt cac aga 1230 Ser Leu Pro Gln Glu Cys Glu Lys Glu Leu Ala Ser Leu Cys His Arg 345 350 355 cta ctt cat cag tcg ctt atc tgg agc tgg gac caa ggt ttc tgc cag 1278 Leu Leu His Gln Ser Leu Ile Trp Ser Trp Asp Gln Gly Phe Cys Gln 360 365 370 gcc ttg gga tca gct ctt ggg ggt cag agc agc ctt ccc aca tcc tct 1326 Ala Leu Gly Ser Ala Leu Gly Gly Gln Ser Ser Leu Pro Thr Ser Ser 375 380 385 ggc act gct gaa ctt ttg cag cag ctc ttt cct cct ctc ttg gat gcc 1374 Gly Thr Ala Glu Leu Leu Gln Gln Leu Phe Pro Pro Leu Leu Asp Ala 390 395 400 405 ctt cga gag ccc agg tta cga cgg att ttc tgc cag cct gca ggt ctc 1422 Leu Arg Glu Pro Arg Leu Arg Arg Ile Phe Cys Gln Pro Ala Gly Leu 410 415 420 tgt acc ctt cag acc acc ttg ctc tgg ttc ctg ggc aga gct cag cag 1470 Cys Thr Leu Gln Thr Thr Leu Leu Trp Phe Leu Gly Arg Ala Gln Gln 425 430 435 tac ttg gca gca tgg gac cca gct tcc ttc ctg ctc ctg atc caa aag 1518 Tyr Leu Ala Ala Trp Asp Pro Ala Ser Phe Leu Leu Leu Ile Gln Lys 440 445 450 gac tta cct cct ctg ttg cat gag gca gaa gct ttg tat agc ctg gcc 1566 Asp Leu Pro Pro Leu Leu His Glu Ala Glu Ala Leu Tyr Ser Leu Ala 455 460 465 tca gag gaa agc tta gct ctg gaa gtg gag cag cag ctg ggc ctg gag 1614 Ser Glu Glu Ser Leu Ala Leu Glu Val Glu Gln Gln Leu Gly Leu Glu 470 475 480 485 atc cag aag ctg act gca cag atc cag ctc ctg cct gaa gag tca cta 1662 Ile Gln Lys Leu Thr Ala Gln Ile Gln Leu Leu Pro Glu Glu Ser Leu 490 495 500 agt gtc ttt tct caa gaa tgt cat aaa caa gcc atg caa ggt ttc aag 1710 Ser Val Phe Ser Gln Glu Cys His Lys Gln Ala Met Gln Gly Phe Lys 505 510 515 ctc tac atg cca cgg ggt cgg tac tgg cgg ctt cgt ctc tgt cct gaa 1758 Leu Tyr Met Pro Arg Gly Arg Tyr Trp Arg Leu Arg Leu Cys Pro Glu 520 525 530 cct ccc agt gct cct agt gag tat gct ggt tta gtg gtc cgc acc gta 1806 Pro Pro Ser Ala Pro Ser Glu Tyr Ala Gly Leu Val Val Arg Thr Val 535 540 545 ctg gag cct gtg ttg caa gga ttg caa ggg ttg cca cct caa gcc cag 1854 Leu Glu Pro Val Leu Gln Gly Leu Gln Gly Leu Pro Pro Gln Ala Gln 550 555 560 565 gcc cct gcc ctt ggt cag gct ctg acg gcc atc gtg ggt gcc tgg ctt 1902 Ala Pro Ala Leu Gly Gln Ala Leu Thr Ala Ile Val Gly Ala Trp Leu 570 575 580 gac cac att ctt acc cat ggg att cgg ttc agc ctg cag gga gcg ctg 1950 Asp His Ile Leu Thr His Gly Ile Arg Phe Ser Leu Gln Gly Ala Leu 585 590 595 cag ctc aaa caa gac ttt gga gtg gtc agg gag ttg ctg gaa gag gag 1998 Gln Leu Lys Gln Asp Phe Gly Val Val Arg Glu Leu Leu Glu Glu Glu 600 605 610 cag tgg agc ctg tcc cct gat ctc cgc cag acc ctg ctc atg ctc agc 2046 Gln Trp Ser Leu Ser Pro Asp Leu Arg Gln Thr Leu Leu Met Leu Ser 615 620 625 atc ttc cag cag ctg gat ggg gcc cta ctg tgt ctg ttg cag cag ccc 2094 Ile Phe Gln Gln Leu Asp Gly Ala Leu Leu Cys Leu Leu Gln Gln Pro 630 635 640 645 ctg ccc aag tct caa gtc cac agg agg ccc ccc tgt tgc tgt gct tgt 2142 Leu Pro Lys Ser Gln Val His Arg Arg Pro Pro Cys Cys Cys Ala Cys 650 655 660 cag gag gtc cag acc acg aaa ttg ccc agc agc tgc ctc aat agc ctg 2190 Gln Glu Val Gln Thr Thr Lys Leu Pro Ser Ser Cys Leu Asn Ser Leu 665 670 675 gag agc ttg gag ccc ccg ctc cag cct gga aca tct cca gcc cag aca 2238 Glu Ser Leu Glu Pro Pro Leu Gln Pro Gly Thr Ser Pro Ala Gln Thr 680 685 690 ggt cag ctg caa agc aca cta gga gga agg gga cct agc ccg gag ggc 2286 Gly Gln Leu Gln Ser Thr Leu Gly Gly Arg Gly Pro Ser Pro Glu Gly 695 700 705 tac ctg gtg gga aat cag cag gcc tgg ctt gcc ctc agg caa cac cag 2334 Tyr Leu Val Gly Asn Gln Gln Ala Trp Leu Ala Leu Arg Gln His Gln 710 715 720 725 cga ccc cgt tgg cac ctg ccg ttt ttt tcc tgc ctg gga acc agt cct 2382 Arg Pro Arg Trp His Leu Pro Phe Phe Ser Cys Leu Gly Thr Ser Pro 730 735 740 gaa tcc taaggagcct gggaccagga gccagaaagt taagagctcc ccatctctag 2438 Glu Ser ctggaaaatc cagacatttg gaattgcata ttaaggaagc ccagaactgg aagcttggag 2498 gaaagcatac tggagaataa gctacaaaga gcctgggctt aagaatccaa gattaggggc 2558 tgggcgaggt ggctcacgcc tgtaatccag cactttggga gaccgaggca ggcggatcat 2618 gaggtcagga gatcaagacc atcctggcta acacggtgaa accctgtttc cactaaaaat 2678 acaaaaaatt agccgggcgt ggtggcgggt gcctgtagtc ccagctactc gggaggctga 2738 ggcaggagaa tggtgtgaac ctgggaggcg gagcttgcag tgagctgaga tccagccaca 2798 gcactccagc ctgggtgaca gagcaagact ctgtctc 2835 <210> 274 <211> 743 <212> PRT <213> Homo sapiens <400> 274 Met Ala Gln Ala Ser Arg Ser Gly Ser Leu Pro Pro Leu Val Ile Val 1 5 10 15 Pro Pro Leu Arg Ala Gln Pro Gly Gly Thr Gly Glu Glu Gln Trp Glu 20 25 30 Arg Ser Arg Thr Gly Gly Leu Arg Trp Glu Val His Cys Trp Pro Ser 35 40 45 Gly Thr Ser Gly Gly Thr Pro Trp Trp Pro Thr Pro Ala Asp Val Ser 50 55 60 Glu Asp Tyr Glu Ala Asp Ala Ala Ala Trp Arg Arg Gly Pro Ala Gly 65 70 75 80 Gly Gly Pro Ile Pro Pro Ala Leu Gln Arg Leu Arg Ala Val Leu Leu 85 90 95 Arg Leu His Arg Glu Arg Glu Gln Leu Leu Gln Ala Arg Asp Cys Ala 100 105 110 Tyr His Leu Gln Ser Ala Val Arg Leu Met Lys Thr Leu Ser Pro Gly 115 120 125 Ser Pro Ser Gly Gly Pro Ser Pro Leu Pro Gln Trp Tyr Arg Asp Leu 130 135 140 Gln Leu His Pro Ser Gln Gly Ala Val Leu Arg Ile Gly Pro Gly Glu 145 150 155 160 Thr Leu Glu Pro Leu Leu Leu Ala Arg Pro Ile Gly Leu Ala Ala Gln 165 170 175 Cys Leu Glu Ala Val Ile Glu Met Gln Leu Arg Ala Leu Gly Arg Glu 180 185 190 Pro Ala Ser Pro Gly Leu Ser Ser Gln Leu Ala Glu Leu Leu Phe Ala 195 200 205 Leu Pro Ala Tyr His Thr Leu Gln Arg Lys Ala Leu Ser His Val Pro 210 215 220 Gly Ala Ala Arg Pro Phe Pro Thr Ser Arg Val Leu Arg Leu Leu Thr 225 230 235 240 Gly Glu Arg Gly Cys Gln Val Ala Ser Arg Leu Asp Glu Ala Leu Gln 245 250 255 Gly Ser Ala Leu Arg Asp Gln Leu Arg Arg Arg Cys Gln Glu Glu Gly 260 265 270 Asp Leu Leu Pro Gly Leu Leu Gly Leu Val Gly Gly Val Ala Gly Ser 275 280 285 Ala Ser Cys Gly Leu Gly Leu Gly Gly Ala Gly Ala Leu Trp Cys Gln 290 295 300 Tyr Trp Thr Leu Leu Trp Ala Ala Cys Ala Gln Ser Leu Asp Leu Asn 305 310 315 320 Leu Gly Pro Trp Arg Asp Pro Arg Ala Thr Ala Gln Gln Leu Ser Gln 325 330 335 Ala Leu Gly Gln Ala Ser Leu Pro Gln Glu Cys Glu Lys Glu Leu Ala 340 345 350 Ser Leu Cys His Arg Leu Leu His Gln Ser Leu Ile Trp Ser Trp Asp 355 360 365 Gln Gly Phe Cys Gln Ala Leu Gly Ser Ala Leu Gly Gly Gln Ser Ser 370 375 380 Leu Pro Thr Ser Ser Gly Thr Ala Glu Leu Leu Gln Gln Leu Phe Pro 385 390 395 400 Pro Leu Leu Asp Ala Leu Arg Glu Pro Arg Leu Arg Arg Ile Phe Cys 405 410 415 Gln Pro Ala Gly Leu Cys Thr Leu Gln Thr Thr Leu Leu Trp Phe Leu 420 425 430 Gly Arg Ala Gln Gln Tyr Leu Ala Ala Trp Asp Pro Ala Ser Phe Leu 435 440 445 Leu Leu Ile Gln Lys Asp Leu Pro Pro Leu Leu His Glu Ala Glu Ala 450 455 460 Leu Tyr Ser Leu Ala Ser Glu Glu Ser Leu Ala Leu Glu Val Glu Gln 465 470 475 480 Gln Leu Gly Leu Glu Ile Gln Lys Leu Thr Ala Gln Ile Gln Leu Leu 485 490 495 Pro Glu Glu Ser Leu Ser Val Phe Ser Gln Glu Cys His Lys Gln Ala 500 505 510 Met Gln Gly Phe Lys Leu Tyr Met Pro Arg Gly Arg Tyr Trp Arg Leu 515 520 525 Arg Leu Cys Pro Glu Pro Pro Ser Ala Pro Ser Glu Tyr Ala Gly Leu 530 535 540 Val Val Arg Thr Val Leu Glu Pro Val Leu Gln Gly Leu Gln Gly Leu 545 550 555 560 Pro Pro Gln Ala Gln Ala Pro Ala Leu Gly Gln Ala Leu Thr Ala Ile 565 570 575 Val Gly Ala Trp Leu Asp His Ile Leu Thr His Gly Ile Arg Phe Ser 580 585 590 Leu Gln Gly Ala Leu Gln Leu Lys Gln Asp Phe Gly Val Val Arg Glu 595 600 605 Leu Leu Glu Glu Glu Gln Trp Ser Leu Ser Pro Asp Leu Arg Gln Thr 610 615 620 Leu Leu Met Leu Ser Ile Phe Gln Gln Leu Asp Gly Ala Leu Leu Cys 625 630 635 640 Leu Leu Gln Gln Pro Leu Pro Lys Ser Gln Val His Arg Arg Pro Pro 645 650 655 Cys Cys Cys Ala Cys Gln Glu Val Gln Thr Thr Lys Leu Pro Ser Ser 660 665 670 Cys Leu Asn Ser Leu Glu Ser Leu Glu Pro Pro Leu Gln Pro Gly Thr 675 680 685 Ser Pro Ala Gln Thr Gly Gln Leu Gln Ser Thr Leu Gly Gly Arg Gly 690 695 700 Pro Ser Pro Glu Gly Tyr Leu Val Gly Asn Gln Gln Ala Trp Leu Ala 705 710 715 720 Leu Arg Gln His Gln Arg Pro Arg Trp His Leu Pro Phe Phe Ser Cys 725 730 735 Leu Gly Thr Ser Pro Glu Ser 740 <210> 275 <211> 2063 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (27)..(887) <400> 275 actctggcac cactctccag gctgcc atg ggg ccc agc acc cct ctc ctc atc 53 Met Gly Pro Ser Thr Pro Leu Leu Ile 1 5 ttg ttc ctt ttg tca tgg tcg gga ccc ctc caa gga cag cag cac cac 101 Leu Phe Leu Leu Ser Trp Ser Gly Pro Leu Gln Gly Gln Gln His His 10 15 20 25 ctt gtg gag tac atg gaa cgc cga cta gct gct tta gag gaa cgg ctg 149 Leu Val Glu Tyr Met Glu Arg Arg Leu Ala Ala Leu Glu Glu Arg Leu 30 35 40 gcc cag tgc cag gac cag agt agt cgg cat gct gct gag ctg cgg gac 197 Ala Gln Cys Gln Asp Gln Ser Ser Arg His Ala Ala Glu Leu Arg Asp 45 50 55 ttc aag aac aag atg ctg cca ctg ctg gag gtg gca gag aag gag cgg 245 Phe Lys Asn Lys Met Leu Pro Leu Leu Glu Val Ala Glu Lys Glu Arg 60 65 70 gag gca ctc aga act gag gcc gac acc atc tcc ggg aga gtg gat cgt 293 Glu Ala Leu Arg Thr Glu Ala Asp Thr Ile Ser Gly Arg Val Asp Arg 75 80 85 ctg gag cgg gag gta gac tat ctg gag acc cag aac cca gct ctg ccc 341 Leu Glu Arg Glu Val Asp Tyr Leu Glu Thr Gln Asn Pro Ala Leu Pro 90 95 100 105 tgt gta gag ttt gat gag aag gtg act gga ggc cct ggg acc aaa ggc 389 Cys Val Glu Phe Asp Glu Lys Val Thr Gly Gly Pro Gly Thr Lys Gly 110 115 120 aag gga aga agg aat gag aag tac gat atg gtg aca ggt aaa caa tct 437 Lys Gly Arg Arg Asn Glu Lys Tyr Asp Met Val Thr Gly Lys Gln Ser 125 130 135 gaa agc agg ccc cta act ctt ctc aga acc gat att ctt cct tcc ttg 485 Glu Ser Arg Pro Leu Thr Leu Leu Arg Thr Asp Ile Leu Pro Ser Leu 140 145 150 ctt ctt act ctt ttt ttc act ttg tcc cag tcc att gtg gct ctg tct 533 Leu Leu Thr Leu Phe Phe Thr Leu Ser Gln Ser Ile Val Ala Leu Ser 155 160 165 tct gga atc tgt ttt agg gaa acc tct gta atg cca ggt cta tta agg 581 Ser Gly Ile Cys Phe Arg Glu Thr Ser Val Met Pro Gly Leu Leu Arg 170 175 180 185 aga ggt tct ggg gat cca ggc cgc tgt ggt acc cgc tct ttc tca att 629 Arg Gly Ser Gly Asp Pro Gly Arg Cys Gly Thr Arg Ser Phe Ser Ile 190 195 200 ctc cct aag att gga ggc aac cgc tgg gca aat gct cac tat tct cca 677 Leu Pro Lys Ile Gly Gly Asn Arg Trp Ala Asn Ala His Tyr Ser Pro 205 210 215 gat cac cca ccc tgg ggg agt tcc tgc tgg agg cat cta att ctt gcc 725 Asp His Pro Pro Trp Gly Ser Ser Cys Trp Arg His Leu Ile Leu Ala 220 225 230 tct att tcc ttt tcc tgt gct ttt ctc atc aga ctg tgg cta cac aat 773 Ser Ile Ser Phe Ser Cys Ala Phe Leu Ile Arg Leu Trp Leu His Asn 235 240 245 ctc tca agt gag atc aat gaa gat tct gaa gcg att tgg tgg ccc agc 821 Leu Ser Ser Glu Ile Asn Glu Asp Ser Glu Ala Ile Trp Trp Pro Ser 250 255 260 265 tgg tct atg gac caa gga tcc act ggg gca aac aga gaa gat cta cgt 869 Trp Ser Met Asp Gln Gly Ser Thr Gly Ala Asn Arg Glu Asp Leu Arg 270 275 280 gtt aga tgg gac aca gaa tgacacagcc tttgtcttcc caaggctgcg 917 Val Arg Trp Asp Thr Glu 285 tgacttcacc cttgccatgg ctgcccggaa agcttcccga gtccgggtgc ccttcccctg 977 ggtaggcaca gggcagctgg tatatggtgg ctttctttat tttgctcgga ggcctcctgg 1037 aagacctggt ggaggtggtg agatggagaa cactttgcag ctaatcaaat tccacctggc 1097 aaaccgaaca gtggtggaca gctcagtatt cccagcagag gggctgatcc ccccctacgg 1157 cttgacagca gacacctaca tcgacctggc agctgatgag gaaggtcttt gggctgtcta 1217 tgccacccgg gaggatgaca ggcacttgtg tctggccaag ttagatccac agacactgga 1277 cacagagcag cagtgggaca caccatgtcc cagagagaat gctgaggctg cctttgtcat 1337 ctgtgggacc ctctatgtcg tctataacac ccgtcctgcc agtcgggccc gcatccagtg 1397 ctcctttgat gccagcggca ccctgacccc tgaacgggca gcactccctt attttccccg 1457 cagatatggt gcccatgcca gcctccgcta taacccccga gaacgccagc tctatgcctg 1517 ggatgatggc taccagattg tctataagct ggagatgagg aagaaagagg aggaggtttg 1577 aggagctagc cttgtctttt gcatctttct cactcccata catttatatt atatccccac 1637 taaatttctt gttcctcatt cttcaaatgt gggccagttg tggctcaaat cctctatatt 1697 tttagccaat ggcaatcaaa ttctttcagc tcctttgttt catacggaac tccagatcct 1757 gagtaatcct tttagagccc gaagagtcaa aaccctcaat gttccctcct gctctcctgc 1817 cccatgtcaa caaatttcag gctaaggatg ccccagaccc agggctctaa ccttgtatgc 1877 gggcaggccc agggagcagg cagcagtgtt cttcccctca gagtgacttg gggagggaga 1937 aataggagga gacgtccagc tctgtcctct cttcctcact cctcccttca gtgtcctgag 1997 gaacaggact ttctccacat tgttttgtat tgcaacattt tgcattaaaa ggaaaatcca 2057 ctgctc 2063 <210> 276 <211> 287 <212> PRT <213> Homo sapiens <400> 276 Met Gly Pro Ser Thr Pro Leu Leu Ile Leu Phe Leu Leu Ser Trp Ser 1 5 10 15 Gly Pro Leu Gln Gly Gln Gln His His Leu Val Glu Tyr Met Glu Arg 20 25 30 Arg Leu Ala Ala Leu Glu Glu Arg Leu Ala Gln Cys Gln Asp Gln Ser 35 40 45 Ser Arg His Ala Ala Glu Leu Arg Asp Phe Lys Asn Lys Met Leu Pro 50 55 60 Leu Leu Glu Val Ala Glu Lys Glu Arg Glu Ala Leu Arg Thr Glu Ala 65 70 75 80 Asp Thr Ile Ser Gly Arg Val Asp Arg Leu Glu Arg Glu Val Asp Tyr 85 90 95 Leu Glu Thr Gln Asn Pro Ala Leu Pro Cys Val Glu Phe Asp Glu Lys 100 105 110 Val Thr Gly Gly Pro Gly Thr Lys Gly Lys Gly Arg Arg Asn Glu Lys 115 120 125 Tyr Asp Met Val Thr Gly Lys Gln Ser Glu Ser Arg Pro Leu Thr Leu 130 135 140 Leu Arg Thr Asp Ile Leu Pro Ser Leu Leu Leu Thr Leu Phe Phe Thr 145 150 155 160 Leu Ser Gln Ser Ile Val Ala Leu Ser Ser Gly Ile Cys Phe Arg Glu 165 170 175 Thr Ser Val Met Pro Gly Leu Leu Arg Arg Gly Ser Gly Asp Pro Gly 180 185 190 Arg Cys Gly Thr Arg Ser Phe Ser Ile Leu Pro Lys Ile Gly Gly Asn 195 200 205 Arg Trp Ala Asn Ala His Tyr Ser Pro Asp His Pro Pro Trp Gly Ser 210 215 220 Ser Cys Trp Arg His Leu Ile Leu Ala Ser Ile Ser Phe Ser Cys Ala 225 230 235 240 Phe Leu Ile Arg Leu Trp Leu His Asn Leu Ser Ser Glu Ile Asn Glu 245 250 255 Asp Ser Glu Ala Ile Trp Trp Pro Ser Trp Ser Met Asp Gln Gly Ser 260 265 270 Thr Gly Ala Asn Arg Glu Asp Leu Arg Val Arg Trp Asp Thr Glu 275 280 285 <210> 277 <211> 2896 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (196)..(1449) <400> 277 actgtccact tccacgacaa ctctggagat gtcttccatg ctcacagttc ggtcctcaac 60 tttgccacta acagagacga ctttgtgcag atcgggaagg gccccaccaa caacacctgc 120 gttgtccgca cagtcagcgt gggcctgaca ctgctccgtg tgtgggacgc agagcacccg 180 ggcctctcgg acttc atg ccc ctg cct gtc cta cag gcc atc tcc cca gag 231 Met Pro Leu Pro Val Leu Gln Ala Ile Ser Pro Glu 1 5 10 ctg tct ggg gcc atg gtg gtg ggg gac gtg ctc tgt ctg gcc act gtt 279 Leu Ser Gly Ala Met Val Val Gly Asp Val Leu Cys Leu Ala Thr Val 15 20 25 ctg acc agc ctg gaa ggc ctc tca gga acc tgg agc tcc tca acc aac 327 Leu Thr Ser Leu Glu Gly Leu Ser Gly Thr Trp Ser Ser Ser Thr Asn 30 35 40 agc atc ctc cac atc gac ccc aag acg ggt gtg gct gtg gcc cgg gcc 375 Ser Ile Leu His Ile Asp Pro Lys Thr Gly Val Ala Val Ala Arg Ala 45 50 55 60 gtg gga tcc gtg acg gtt tac tat gag gtc gct ggg cac ctg agg acc 423 Val Gly Ser Val Thr Val Tyr Tyr Glu Val Ala Gly His Leu Arg Thr 65 70 75 tac aag gag gtg gtg gtc agc gtc cct cag agg atc atg gcc cgt cac 471 Tyr Lys Glu Val Val Val Ser Val Pro Gln Arg Ile Met Ala Arg His 80 85 90 ctc cac ccc atc cag aca agc ttc cag gag gct aca gcc tcc aaa gtg 519 Leu His Pro Ile Gln Thr Ser Phe Gln Glu Ala Thr Ala Ser Lys Val 95 100 105 att gtt gcc gtg gga gac aga agc tct aac ctg aga ggc gag tgc acc 567 Ile Val Ala Val Gly Asp Arg Ser Ser Asn Leu Arg Gly Glu Cys Thr 110 115 120 ccc acc cag agg gaa gtc atc cag gcc ttg cac cca gag acc ctc atc 615 Pro Thr Gln Arg Glu Val Ile Gln Ala Leu His Pro Glu Thr Leu Ile 125 130 135 140 agc tgc cag tcc cag ttc aag ccg gcc gtc ttt gat ttc cca tct caa 663 Ser Cys Gln Ser Gln Phe Lys Pro Ala Val Phe Asp Phe Pro Ser Gln 145 150 155 gat gtg ttc acc gtg gag cca cag ttt gac act gct ctc ggc cag tac 711 Asp Val Phe Thr Val Glu Pro Gln Phe Asp Thr Ala Leu Gly Gln Tyr 160 165 170 ttc tgc tca atc aca atg cac agg ctg acg gac aag cag cgg aag cac 759 Phe Cys Ser Ile Thr Met His Arg Leu Thr Asp Lys Gln Arg Lys His 175 180 185 ctg agc atg aag aag aca gct ctg gtg gtc agt gcc tcc ctc tcc agc 807 Leu Ser Met Lys Lys Thr Ala Leu Val Val Ser Ala Ser Leu Ser Ser 190 195 200 agc cac ttc tcc aca gag cag gtg ggg gcc gag gtg ccc ttc agc cca 855 Ser His Phe Ser Thr Glu Gln Val Gly Ala Glu Val Pro Phe Ser Pro 205 210 215 220 ggt ctc ttc gcc gac cag gct gaa atc ctt ttg agc aac cac tac acc 903 Gly Leu Phe Ala Asp Gln Ala Glu Ile Leu Leu Ser Asn His Tyr Thr 225 230 235 agt tcc gag atc agg gtc ttt ggt gcc ccg gag gtt ctg gag aac ttg 951 Ser Ser Glu Ile Arg Val Phe Gly Ala Pro Glu Val Leu Glu Asn Leu 240 245 250 gag gtg aaa tcc ggg tcc ccg gcc gtg ctg gca ttc gca aag gag aag 999 Glu Val Lys Ser Gly Ser Pro Ala Val Leu Ala Phe Ala Lys Glu Lys 255 260 265 tct ttt ggg tgg ccc agc ttc atc aca tac acg gtc ggc gtc tcg gac 1047 Ser Phe Gly Trp Pro Ser Phe Ile Thr Tyr Thr Val Gly Val Ser Asp 270 275 280 ccc gcg gct ggc agc caa ggg tct ctg tcc act acc ctg acc ttc tcc 1095 Pro Ala Ala Gly Ser Gln Gly Ser Leu Ser Thr Thr Leu Thr Phe Ser 285 290 295 300 agc cct gtg acc aac caa gcc att gcc atc cca gtg aca gtg gct ttt 1143 Ser Pro Val Thr Asn Gln Ala Ile Ala Ile Pro Val Thr Val Ala Phe 305 310 315 gtg atg gat cgc cgt ggg ccc ggt cct tat gga gcc agc ctc ttc cag 1191 Val Met Asp Arg Arg Gly Pro Gly Pro Tyr Gly Ala Ser Leu Phe Gln 320 325 330 cac ttc ctg gat tcc tac cag gtc atg ttc ttc acg ctc ttc gcc ctg 1239 His Phe Leu Asp Ser Tyr Gln Val Met Phe Phe Thr Leu Phe Ala Leu 335 340 345 ttg gct ggg aca gcg gtc atg atc ata gcc tac cac act gtc tgc acg 1287 Leu Ala Gly Thr Ala Val Met Ile Ile Ala Tyr His Thr Val Cys Thr 350 355 360 ccc cgg gat ctt gct gtg cct gca gcc ctc acg cct cga gcc agc cct 1335 Pro Arg Asp Leu Ala Val Pro Ala Ala Leu Thr Pro Arg Ala Ser Pro 365 370 375 380 gga cac agc ccc cac tat ttc gct gcc tca tca ccc aca tct ccc aat 1383 Gly His Ser Pro His Tyr Phe Ala Ala Ser Ser Pro Thr Ser Pro Asn 385 390 395 gca ttg cct cct gct cgc aaa gcc agc cct ccc tca ggg ctg tgg agc 1431 Ala Leu Pro Pro Ala Arg Lys Ala Ser Pro Pro Ser Gly Leu Trp Ser 400 405 410 cca gcc tat gcc tcc cac taggccgcgt gaaggttccc ggaggatggg 1479 Pro Ala Tyr Ala Ser His 415 tctcagccga gcctcgtgca cccccaagat ggaacatccc tgctgcattc acactggaac 1539 aagcccctcc agatgagtgc cccggcccca ggccagcttc actgccgtct cttcacacag 1599 agctgtagtt tcggctctgc ccattagctc attttatgta ggagttttaa atgtgtgttt 1659 ttttcctttc aagtcttaca aagctaagac tttttggctc attccttttt gcatggttgt 1719 ctagggtttc tggacaatgt gctgttgcat ttttattttc ctagccttgc taaaatcttt 1779 cccttctcaa gactttgagc agttagaagt gctctttaga agttgtctgt gggtgatgtt 1839 actgtagtgg tctcagggaa aggattgtcc agttacttta gggggttttt ggtggggttt 1899 ttccccctgt gaaaacttac tttgccccta gtctggctgc tgctaggact tctgaggagc 1959 aatgggacat gagtgtccct gtatctgcgc cactgccgca agggaagcct caggaaccag 2019 cacctggagg ccaggatagc caagccctgg gtgagcgaga ggctggagaa cacaggagct 2079 cacccagggc tgctgcccaa ccatgggcca ctgtgaacag acttcagtcc tctgtttttg 2139 tttcataagc cgttgagaca tctgatggac ttggcttagg ccctgctggg acatcccacg 2199 tgtgatccct ttcactccat caggacacca ggactgtcct taggaaaatg tccttgagat 2259 ggcagcagga gtcatatttt ctgtgtgtgt gtttcggaaa gccgctgtgt cctgcctcag 2319 cacaaagacc cagtgtcatt tgctcctcct gttcctgtgc cactccagaa cctcagcaga 2379 tctgagccac cgcctgccag tgtgagaggc ggccactttc atggcagctt atcaggcgca 2439 gggccccaga cagcttccca gccggcccta gagcccggcc tgggccaatg atggagggcg 2499 gccaccagcc cagggcctgc ccatccagaa gggactcccc agggcctggg ggaggagacc 2559 cttggaaaag tcctctcttc ccagctcctg attctggatc tgagattctc agatcacagg 2619 cccctgtgct ccaggccgag gctgggccac cctcagggag atccagagac tcatgcccat 2679 ggccatccat gcgtggacgc tgtgtggaga gtccaggatg acgggatccc gcacaagctc 2739 ccttcagtcc ttcagggctg ggccatgtgg ttgatttttc taaagctgga gaaaggaaga 2799 attgtgcctt gcatattact tgagcttaaa ctgacaacct ggatgtaaat aggagccttt 2859 ctactggttt atttaataaa gttctatgtg atttttt 2896 <210> 278 <211> 418 <212> PRT <213> Homo sapiens <400> 278 Met Pro Leu Pro Val Leu Gln Ala Ile Ser Pro Glu Leu Ser Gly Ala 1 5 10 15 Met Val Val Gly Asp Val Leu Cys Leu Ala Thr Val Leu Thr Ser Leu 20 25 30 Glu Gly Leu Ser Gly Thr Trp Ser Ser Ser Thr Asn Ser Ile Leu His 35 40 45 Ile Asp Pro Lys Thr Gly Val Ala Val Ala Arg Ala Val Gly Ser Val 50 55 60 Thr Val Tyr Tyr Glu Val Ala Gly His Leu Arg Thr Tyr Lys Glu Val 65 70 75 80 Val Val Ser Val Pro Gln Arg Ile Met Ala Arg His Leu His Pro Ile 85 90 95 Gln Thr Ser Phe Gln Glu Ala Thr Ala Ser Lys Val Ile Val Ala Val 100 105 110 Gly Asp Arg Ser Ser Asn Leu Arg Gly Glu Cys Thr Pro Thr Gln Arg 115 120 125 Glu Val Ile Gln Ala Leu His Pro Glu Thr Leu Ile Ser Cys Gln Ser 130 135 140 Gln Phe Lys Pro Ala Val Phe Asp Phe Pro Ser Gln Asp Val Phe Thr 145 150 155 160 Val Glu Pro Gln Phe Asp Thr Ala Leu Gly Gln Tyr Phe Cys Ser Ile 165 170 175 Thr Met His Arg Leu Thr Asp Lys Gln Arg Lys His Leu Ser Met Lys 180 185 190 Lys Thr Ala Leu Val Val Ser Ala Ser Leu Ser Ser Ser His Phe Ser 195 200 205 Thr Glu Gln Val Gly Ala Glu Val Pro Phe Ser Pro Gly Leu Phe Ala 210 215 220 Asp Gln Ala Glu Ile Leu Leu Ser Asn His Tyr Thr Ser Ser Glu Ile 225 230 235 240 Arg Val Phe Gly Ala Pro Glu Val Leu Glu Asn Leu Glu Val Lys Ser 245 250 255 Gly Ser Pro Ala Val Leu Ala Phe Ala Lys Glu Lys Ser Phe Gly Trp 260 265 270 Pro Ser Phe Ile Thr Tyr Thr Val Gly Val Ser Asp Pro Ala Ala Gly 275 280 285 Ser Gln Gly Ser Leu Ser Thr Thr Leu Thr Phe Ser Ser Pro Val Thr 290 295 300 Asn Gln Ala Ile Ala Ile Pro Val Thr Val Ala Phe Val Met Asp Arg 305 310 315 320 Arg Gly Pro Gly Pro Tyr Gly Ala Ser Leu Phe Gln His Phe Leu Asp 325 330 335 Ser Tyr Gln Val Met Phe Phe Thr Leu Phe Ala Leu Leu Ala Gly Thr 340 345 350 Ala Val Met Ile Ile Ala Tyr His Thr Val Cys Thr Pro Arg Asp Leu 355 360 365 Ala Val Pro Ala Ala Leu Thr Pro Arg Ala Ser Pro Gly His Ser Pro 370 375 380 His Tyr Phe Ala Ala Ser Ser Pro Thr Ser Pro Asn Ala Leu Pro Pro 385 390 395 400 Ala Arg Lys Ala Ser Pro Pro Ser Gly Leu Trp Ser Pro Ala Tyr Ala 405 410 415 Ser His <210> 279 <211> 2969 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (38)..(1072) <400> 279 agcaacgacg ccgggcagcg ggagcggcgg ccgcgcc atg tgg ctg ctg ggg ccg 55 Met Trp Leu Leu Gly Pro 1 5 ctg tgc ctg ctg ctg agc agc gcc gcg gag agc cag ctg ctc ccc ggg 103 Leu Cys Leu Leu Leu Ser Ser Ala Ala Glu Ser Gln Leu Leu Pro Gly 10 15 20 aac aac ttc acc aat gag tgc aac ata cca ggc aac ttc atg tgc agc 151 Asn Asn Phe Thr Asn Glu Cys Asn Ile Pro Gly Asn Phe Met Cys Ser 25 30 35 aat gga cgg tgc atc ccg ggc gcc tgg cag tgt gac ggg ctg cct gac 199 Asn Gly Arg Cys Ile Pro Gly Ala Trp Gln Cys Asp Gly Leu Pro Asp 40 45 50 tgc ttc gac aag agt gat gag aag gag tgc ccc aag gct aag tcg aaa 247 Cys Phe Asp Lys Ser Asp Glu Lys Glu Cys Pro Lys Ala Lys Ser Lys 55 60 65 70 tgt ggc cca acc ttc ttc ccc tgt gcc agc ggc atc cat tgc atc att 295 Cys Gly Pro Thr Phe Phe Pro Cys Ala Ser Gly Ile His Cys Ile Ile 75 80 85 ggt cgc ttc cgg tgc aat ggg ttt gag gac tgt ccc gat ggc agc gat 343 Gly Arg Phe Arg Cys Asn Gly Phe Glu Asp Cys Pro Asp Gly Ser Asp 90 95 100 gaa gag aac tgc aca gca aac cct ctg ctt tgc tcc acc gcc cgc tac 391 Glu Glu Asn Cys Thr Ala Asn Pro Leu Leu Cys Ser Thr Ala Arg Tyr 105 110 115 cac tgc aag aac ggc ctc tgt att gac aag agc ttc atc tgc gat gga 439 His Cys Lys Asn Gly Leu Cys Ile Asp Lys Ser Phe Ile Cys Asp Gly 120 125 130 cag aat aac tgt caa gac aac agt gat gag gaa agc tgt gaa agt tct 487 Gln Asn Asn Cys Gln Asp Asn Ser Asp Glu Glu Ser Cys Glu Ser Ser 135 140 145 150 caa gaa ccc ggc agt ggg cag gtg ttt gtg act tca gag aac caa ctt 535 Gln Glu Pro Gly Ser Gly Gln Val Phe Val Thr Ser Glu Asn Gln Leu 155 160 165 gtg tat tac ccc agc atc acc tat gcc atc atc ggc agc tcc gtc att 583 Val Tyr Tyr Pro Ser Ile Thr Tyr Ala Ile Ile Gly Ser Ser Val Ile 170 175 180 ttt gtg ctg gtg gtg gcc ctg ctg gca ctg gtc ttg cac cac cag cgg 631 Phe Val Leu Val Val Ala Leu Leu Ala Leu Val Leu His His Gln Arg 185 190 195 aag cgg aac aac ctc atg acg ctg ccc gtg cac cgg ctg cag cac cct 679 Lys Arg Asn Asn Leu Met Thr Leu Pro Val His Arg Leu Gln His Pro 200 205 210 gtg ctg ctg tcc cgc ctg gtg gtc ctg gac cac ccc cac cac tgc aac 727 Val Leu Leu Ser Arg Leu Val Val Leu Asp His Pro His His Cys Asn 215 220 225 230 gtc acc tac aac gtc aat aat ggc atc cag tat gtg gcc agc cag gcg 775 Val Thr Tyr Asn Val Asn Asn Gly Ile Gln Tyr Val Ala Ser Gln Ala 235 240 245 gag cag aat gcg tcg gaa gta ggc tcc cca ccc tcc tac tcc gag gcc 823 Glu Gln Asn Ala Ser Glu Val Gly Ser Pro Pro Ser Tyr Ser Glu Ala 250 255 260 ttg ctg gac cag agg cct gcg tgg tat gac ctt cct cca ccg ccc tac 871 Leu Leu Asp Gln Arg Pro Ala Trp Tyr Asp Leu Pro Pro Pro Pro Tyr 265 270 275 tct tct gac acg gaa tct ctg aac caa gcc gac ctg ccc ccc tac cgc 919 Ser Ser Asp Thr Glu Ser Leu Asn Gln Ala Asp Leu Pro Pro Tyr Arg 280 285 290 tcc cgg tcc ggg agt gcc aac agt gcc agc tcc cag gca gcc agc agc 967 Ser Arg Ser Gly Ser Ala Asn Ser Ala Ser Ser Gln Ala Ala Ser Ser 295 300 305 310 ctc ctg agc gtg gaa gac acc agc cac agc ccg ggg cag cct ggc ccc 1015 Leu Leu Ser Val Glu Asp Thr Ser His Ser Pro Gly Gln Pro Gly Pro 315 320 325 cag gag ggc act gct gag ccc agg gac tct gag ccc agc cag ggc act 1063 Gln Glu Gly Thr Ala Glu Pro Arg Asp Ser Glu Pro Ser Gln Gly Thr 330 335 340 gaa gaa gta taagtcccag ttattccaaa gtccatatgg gttaatctgc 1112 Glu Glu Val 345 tctgacttgt tgccattcta acaatttgtg ctcatgggaa gctctttaag cacctgtaag 1172 gatgtctcaa gttacagttt gggatattaa ctatctctgc attcccctcc tcccccagac 1232 ttcagagatg tttttctggc gtctcagttg acatgatctg ttgtgcgtct tttctgtcag 1292 gtcactcttc ccttgggacc cgagatcaca ccctcatttt tcacattatt ctgtttctgt 1352 tggagagaca gcatataaaa cagtattgaa ataggctggg agagagcaat gtttctgtgc 1412 tatattggat gctcagaagt gcaggagacg ctggacccaa ttctctctgc tgggtagtta 1472 ccttatagca tttggggatt tgggttagat gatctaacca ggaggccatc actggatggt 1532 caccccccca aaaaaattcc atttgagcat caaaacctgc tttgcacaat cctatttgat 1592 gcccccagtt cagcagagtc agtggccaaa gaaaactttg gacgtgagta acacccttca 1652 gcagtcgcaa cgttattttg gttttgtgaa ggactctgaa accatctacc ctgtataaat 1712 tctggcttta gaaatttgcc caagaatgct cattctgaga gctttcctca gcagcatata 1772 tcatcagcct catcctaaaa taggcaggga gcccctccca tgagtttatc caagttctca 1832 gctcctaaaa tgcaggctgc caagacccta cacctgccct ggctctacag ccacttacct 1892 ggtttctgga ctgtcaccct cccagctgac ctgcccgtag ccaaggaatg aggacctaac 1952 ttgagttggc ccaaagtctg acctggctgt atgtccctgt ggcccacacc cagcctgtct 2012 tgctcattca tgcagcctca acactggcct ccaaagttcc cttaacactt gcaaagtcct 2072 ttttacctgt gcatttggac ttgaggacac tggtttctat cacaggtgag agccatgttc 2132 aatacctcca gcaagctctc ctggctccct gcactgtgca cgctcctctt cccaaggtcc 2192 caataccagc acctctagtt agagttaggg tcagggtcag gcctctccca acatcccagt 2252 agtttctcct ctgagacaca tgggcaagag acaatttgga gtcaagattt tccatttgga 2312 tctattttaa atcttttaga aatgcatttg aaacagtgtg tttgtttttt cccttctagt 2372 taagggacta tttatatgtg tataggaaag ctgtctcttt ttttgttttt cctttaacaa 2432 ggtccaaaga aagatgcaaa aggagatcac acccttgccc cgctgagccc cgtgataaca 2492 agtcactcca gactaacctg tgtgccagac atttgtgcat tgttgcactt tgaggttatt 2552 atttatcaag ttcttgaagg aagcagaaag agggactcct ctctccctcc gtgtatagtc 2612 tctatgtttg tgctagtttt tctttttttt ctctgtgtcc agtcagccac agggcccgcc 2672 tccctgcagg aataaggggt aaaacgttag gtgttgtttg gcaagaaacc acactgactg 2732 atgaggggta aaatggaacc aggtagagcc actccgggca gctgtcaccc attcagaact 2792 tctttccgca gctgaagaaa tgttcagtaa cctgtttgac gctaattaaa acagagcctg 2852 caggaagtgg ggctaaagtg gcattcagtg atcctgttct gtagactttt ctttcttttt 2912 ttaaccaaat ccaaaggatg ttacagaaaa gctagccact ggtattttgt tttgttt 2969 <210> 280 <211> 345 <212> PRT <213> Homo sapiens <400> 280 Met Trp Leu Leu Gly Pro Leu Cys Leu Leu Leu Ser Ser Ala Ala Glu 1 5 10 15 Ser Gln Leu Leu Pro Gly Asn Asn Phe Thr Asn Glu Cys Asn Ile Pro 20 25 30 Gly Asn Phe Met Cys Ser Asn Gly Arg Cys Ile Pro Gly Ala Trp Gln 35 40 45 Cys Asp Gly Leu Pro Asp Cys Phe Asp Lys Ser Asp Glu Lys Glu Cys 50 55 60 Pro Lys Ala Lys Ser Lys Cys Gly Pro Thr Phe Phe Pro Cys Ala Ser 65 70 75 80 Gly Ile His Cys Ile Ile Gly Arg Phe Arg Cys Asn Gly Phe Glu Asp 85 90 95 Cys Pro Asp Gly Ser Asp Glu Glu Asn Cys Thr Ala Asn Pro Leu Leu 100 105 110 Cys Ser Thr Ala Arg Tyr His Cys Lys Asn Gly Leu Cys Ile Asp Lys 115 120 125 Ser Phe Ile Cys Asp Gly Gln Asn Asn Cys Gln Asp Asn Ser Asp Glu 130 135 140 Glu Ser Cys Glu Ser Ser Gln Glu Pro Gly Ser Gly Gln Val Phe Val 145 150 155 160 Thr Ser Glu Asn Gln Leu Val Tyr Tyr Pro Ser Ile Thr Tyr Ala Ile 165 170 175 Ile Gly Ser Ser Val Ile Phe Val Leu Val Val Ala Leu Leu Ala Leu 180 185 190 Val Leu His His Gln Arg Lys Arg Asn Asn Leu Met Thr Leu Pro Val 195 200 205 His Arg Leu Gln His Pro Val Leu Leu Ser Arg Leu Val Val Leu Asp 210 215 220 His Pro His His Cys Asn Val Thr Tyr Asn Val Asn Asn Gly Ile Gln 225 230 235 240 Tyr Val Ala Ser Gln Ala Glu Gln Asn Ala Ser Glu Val Gly Ser Pro 245 250 255 Pro Ser Tyr Ser Glu Ala Leu Leu Asp Gln Arg Pro Ala Trp Tyr Asp 260 265 270 Leu Pro Pro Pro Pro Tyr Ser Ser Asp Thr Glu Ser Leu Asn Gln Ala 275 280 285 Asp Leu Pro Pro Tyr Arg Ser Arg Ser Gly Ser Ala Asn Ser Ala Ser 290 295 300 Ser Gln Ala Ala Ser Ser Leu Leu Ser Val Glu Asp Thr Ser His Ser 305 310 315 320 Pro Gly Gln Pro Gly Pro Gln Glu Gly Thr Ala Glu Pro Arg Asp Ser 325 330 335 Glu Pro Ser Gln Gly Thr Glu Glu Val 340 345 <210> 281 <211> 2872 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (9)..(716) <400> 281 aaaaactg atg ttt gta ttc aat ttc ttc ata ttt ctg ggc ggg gcc tgc 50 Met Phe Val Phe Asn Phe Phe Ile Phe Leu Gly Gly Ala Cys 1 5 10 ctg ctg gcc atc ggc atc tgg gtc atg gtg gac ccc acc ggc ttc cgg 98 Leu Leu Ala Ile Gly Ile Trp Val Met Val Asp Pro Thr Gly Phe Arg 15 20 25 30 gag atc gtg gct gcc aat cct ctg ctc ctc acg ggc gcc tac atc ctc 146 Glu Ile Val Ala Ala Asn Pro Leu Leu Leu Thr Gly Ala Tyr Ile Leu 35 40 45 ctg gcc atg ggg ggc ctg ctc ttt ctg ctc ggc ttc ctg ggc tgc tgc 194 Leu Ala Met Gly Gly Leu Leu Phe Leu Leu Gly Phe Leu Gly Cys Cys 50 55 60 ggg gcc gtc cgt gag aac aag tgt ctg ctg cta ttt ttc ttc ctg ttc 242 Gly Ala Val Arg Glu Asn Lys Cys Leu Leu Leu Phe Phe Phe Leu Phe 65 70 75 atc ctg atc atc ttc ctg gca gag ctc tca gca gcc atc ctg gcc ttc 290 Ile Leu Ile Ile Phe Leu Ala Glu Leu Ser Ala Ala Ile Leu Ala Phe 80 85 90 atc ttc agg gaa aat ctc acc cga gaa ttc ttc acc aag gag ctc acc 338 Ile Phe Arg Glu Asn Leu Thr Arg Glu Phe Phe Thr Lys Glu Leu Thr 95 100 105 110 aag cac tac cag ggc aat aac gac aca gac gtc ttc tct gcc acc tgg 386 Lys His Tyr Gln Gly Asn Asn Asp Thr Asp Val Phe Ser Ala Thr Trp 115 120 125 aac tcg gtc atg atc aca ttt ggt tgc tgc ggg gtc aac ggg cct gaa 434 Asn Ser Val Met Ile Thr Phe Gly Cys Cys Gly Val Asn Gly Pro Glu 130 135 140 gac ttt aag ttt gca tct gtg ttt cga ctc ctg acc ctg gat agt gaa 482 Asp Phe Lys Phe Ala Ser Val Phe Arg Leu Leu Thr Leu Asp Ser Glu 145 150 155 gag gtg ccg gag gcc tgc tgc cgg agg gaa ccc caa agt cgg gac ggg 530 Glu Val Pro Glu Ala Cys Cys Arg Arg Glu Pro Gln Ser Arg Asp Gly 160 165 170 gtc ctg ctg agc cgg gag gag tgc ctc ctg gga agg agc cta ttc cta 578 Val Leu Leu Ser Arg Glu Glu Cys Leu Leu Gly Arg Ser Leu Phe Leu 175 180 185 190 aac aag cag ggc tgt tac acg gtg atc ctc aac acc ttc gag acc tac 626 Asn Lys Gln Gly Cys Tyr Thr Val Ile Leu Asn Thr Phe Glu Thr Tyr 195 200 205 gtc tac ttg gcc gga gcc ctt gcc atc ggg gta ctg gcc atc gag ctt 674 Val Tyr Leu Ala Gly Ala Leu Ala Ile Gly Val Leu Ala Ile Glu Leu 210 215 220 ttc gcc atg atc ttt gcc atg tgc ctc ttc cgg ggc atc cag 716 Phe Ala Met Ile Phe Ala Met Cys Leu Phe Arg Gly Ile Gln 225 230 235 tagagggtat ggcctgaagc ctgaagactc gccccaccca ccactgccca gcacccaatg 776 tcctcccgtg cccctccccg ctgtcctctt ggccccaggg gagaagatga ggccatcaga 836 gatggccagg agaagggcca ggggaataga gctatttttt taacaaaaca aaatgaagac 896 aaaaatatgg actgatgtat cctcgcctgg actcagggca ggtgccgtgg gttctccaga 956 gaccccagca cctggcccag gatgcaggct gctctagaga ccaaaggaac accaggccca 1016 gcgccctctt tggtccagcc agaccctggg ccctctctcc tcactgcacc aggacctgat 1076 gccaagaaag tgaggattta ggcaacaagg aggcaaaagc aaatctcaga gaagtcatca 1136 aagcccaggg gctgcacgga gattcagctg ccatgtcttt gaggactcgg aacccacagc 1196 gcaatccctg gtccactgga ggatggactg ttcccccctt caggccgggg ccaagagtga 1256 gctgctaaca cggcatccaa gaatggccca gctggtagga tccttgcttt ccccatctgt 1316 tggaccaaat aatctcaaag gcccagagag gacagtgacc atccacagac acacagcaca 1376 ggcgtgacag ttctgaaaag aagctgagtt gtctccaggc tgctgtcact gcatccagga 1436 ctctgtcagc tctgctgccc acatgcaccc ctggcctcag catcccggtt cccccagaca 1496 agagagggca agtcagccag gaactgcctc ctccctgctc tacagctaag aaaacaccat 1556 tccatgactt cccaccgcgc cctcgctcct acctccccac acctctctct cagtccccag 1616 gaacacacag aggtgcacat cacattccct tgtccacact gcccgcctct cccacatgcc 1676 acccccttcc ctgtccttcc ccaactcccc agctccaaga gtggaagaaa tccccaagat 1736 catctgggtc tccctctcca cacccagaac tgaggcttgg atatcttctt caacatcctt 1796 gccaagactt ctccaccctc ttgcatacct ccagggacag agagcttact acctcccaag 1856 gcagcctcct gcctttggac tgctctgact ttagcatcag cttaatacac agaagaggtt 1916 tctgtttttc tgtggctctg tccatggcat cccacttgcc cactctcctt cctggagtgt 1976 tgaggtcaca cattgactcc cctgagccct cttctctcca ggctaaagaa tcccgaaggc 2036 atcgaggcca tttctgctgc aacaaggttt cctgtctctt cactgtccgc acatttctta 2096 gtattccctc caggcttggg cagggagact cgcagatgca cacccacaag tattcagttc 2156 tcaaactcta gacgagtgtt ggcaactgga ttgcaagatg ctcctaccct gatagatcag 2216 gggtggctgc tggaggctgt gctggggatc tgaggtttgg tctgggctca gtgggagatg 2276 gcagtgcaat cctgatgagt gatgtctgcc aggcaccgta agtttgatta gtgatgtctg 2336 ccacgggcag ggatggaagg agcagtgtga tgtctgctct cttctctccc ctctgtccct 2396 cttcaggaag aaagagctca ttctgtctca caagccaccg gcatcctgta tcagcttcca 2456 gcctcccctc aggctttcca gtcaccaggg acactcggag ccacagccta gagccccgtg 2516 ttccctggcc tgtgcgtctg cccccttctg agatgcagcc agaagctctg tgcctgctgc 2576 aaagattcag gtggaccctc ctctaatctc ctcctgctgt gcccgccagt ccttgccctc 2636 ccaccaggtc tctgagctca gtcttaccaa attcgccctt taacagcttg ctctggcaac 2696 cccataaatg acacctgagc tccgtagaag ctaagctcct gagacccagg gggacctgcc 2756 actggtaccg cggcccagcc tggggcctgg gggctgcccc tcttgaacca cccacatgct 2816 tagccccagc tttttggaag aggcaaatgg ctggtctgag gatgacacac aaaaac 2872 <210> 282 <211> 236 <212> PRT <213> Homo sapiens <400> 282 Met Phe Val Phe Asn Phe Phe Ile Phe Leu Gly Gly Ala Cys Leu Leu 1 5 10 15 Ala Ile Gly Ile Trp Val Met Val Asp Pro Thr Gly Phe Arg Glu Ile 20 25 30 Val Ala Ala Asn Pro Leu Leu Leu Thr Gly Ala Tyr Ile Leu Leu Ala 35 40 45 Met Gly Gly Leu Leu Phe Leu Leu Gly Phe Leu Gly Cys Cys Gly Ala 50 55 60 Val Arg Glu Asn Lys Cys Leu Leu Leu Phe Phe Phe Leu Phe Ile Leu 65 70 75 80 Ile Ile Phe Leu Ala Glu Leu Ser Ala Ala Ile Leu Ala Phe Ile Phe 85 90 95 Arg Glu Asn Leu Thr Arg Glu Phe Phe Thr Lys Glu Leu Thr Lys His 100 105 110 Tyr Gln Gly Asn Asn Asp Thr Asp Val Phe Ser Ala Thr Trp Asn Ser 115 120 125 Val Met Ile Thr Phe Gly Cys Cys Gly Val Asn Gly Pro Glu Asp Phe 130 135 140 Lys Phe Ala Ser Val Phe Arg Leu Leu Thr Leu Asp Ser Glu Glu Val 145 150 155 160 Pro Glu Ala Cys Cys Arg Arg Glu Pro Gln Ser Arg Asp Gly Val Leu 165 170 175 Leu Ser Arg Glu Glu Cys Leu Leu Gly Arg Ser Leu Phe Leu Asn Lys 180 185 190 Gln Gly Cys Tyr Thr Val Ile Leu Asn Thr Phe Glu Thr Tyr Val Tyr 195 200 205 Leu Ala Gly Ala Leu Ala Ile Gly Val Leu Ala Ile Glu Leu Phe Ala 210 215 220 Met Ile Phe Ala Met Cys Leu Phe Arg Gly Ile Gln 225 230 235 <210> 283 <211> 2694 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (71)..(586) <400> 283 gcgccggctc ggacgcggcc ggctaccgag ccctttgtga gggctgtgag ctgcgcctga 60 cggtggcacc atg agc agc tca ggt ggg gcg ccc ggg gcg tcc gcc agc 109 Met Ser Ser Ser Gly Gly Ala Pro Gly Ala Ser Ala Ser 1 5 10 tct gcg ccg ccc gcg cag gaa gag ggc atg acg tgg tgg tac cgc tgg 157 Ser Ala Pro Pro Ala Gln Glu Glu Gly Met Thr Trp Trp Tyr Arg Trp 15 20 25 ctg tgt cgc ctg tct ggg gtg ctg ggg gca gtc tct tgc gcg atc tct 205 Leu Cys Arg Leu Ser Gly Val Leu Gly Ala Val Ser Cys Ala Ile Ser 30 35 40 45 ggc ctc ttc aac tgc atc acc atc cac cct ctg aac att gcg gcc ggc 253 Gly Leu Phe Asn Cys Ile Thr Ile His Pro Leu Asn Ile Ala Ala Gly 50 55 60 gtg tgg atg atc atg aat gcc ttc atc ttg ttg ctg tgt gag gcg ccc 301 Val Trp Met Ile Met Asn Ala Phe Ile Leu Leu Leu Cys Glu Ala Pro 65 70 75 ttc tgc tgc cag ttc atc gag ttt gca aac aca gtg gcg gag aag gtg 349 Phe Cys Cys Gln Phe Ile Glu Phe Ala Asn Thr Val Ala Glu Lys Val 80 85 90 gac cgg ctg cgc tcc tgg cag aag gct gtc ttc tac tgc ggg atg gcg 397 Asp Arg Leu Arg Ser Trp Gln Lys Ala Val Phe Tyr Cys Gly Met Ala 95 100 105 gtc gtt ccc atc gtc atc agc ctg acc ctg acc acg ctg ctg ggc aac 445 Val Val Pro Ile Val Ile Ser Leu Thr Leu Thr Thr Leu Leu Gly Asn 110 115 120 125 gcc atc gcc ttt gct acg ggg gtg ctg tac gga ctc tct gct ctg ggc 493 Ala Ile Ala Phe Ala Thr Gly Val Leu Tyr Gly Leu Ser Ala Leu Gly 130 135 140 aaa aag ggc gat gcg atc tcc tat gcc agg atc cag cag cag agg cag 541 Lys Lys Gly Asp Ala Ile Ser Tyr Ala Arg Ile Gln Gln Gln Arg Gln 145 150 155 cag gcg gat gag gag aag ctc gcg gag acc ctg gag ggg gag ctg 586 Gln Ala Asp Glu Glu Lys Leu Ala Glu Thr Leu Glu Gly Glu Leu 160 165 170 tgaagggctg ggcgcccctc cctccctgtc ccctcttctg gctctgtgtg ggtccaagtg 646 aggcctggac tgtccacgct gaggcacagc ctggagaggg gcctttgcac gtgtccctac 706 acctggagtc ctctgctcct ttctccagac tggcttaagc caggagccac tggctgctgg 766 tgtgagggtc tgggctgctg gacttgaggc agagcctgca gcagctgtgt ggacactacc 826 cagccctact cctctgctgg gtgggtctgc agatctcaca ccacagacag ggctgcctgt 886 gacctgctgt gacctgggag cagcttcccc tggagatgct ggtcctggct tgaggggagg 946 ggcaagtggg accctgccac ctgggcactg agcagaggga cctcccccag ctctcttagc 1006 aggtggagcc ccagggcctg ggacagcctg ccgctgccag caacctccca ctgctgccta 1066 gggtgcagcg cccactgtca ccctgccttc tgaagaagcc cacagggctc ctaaggtgca 1126 ccccggtacc tggaactgca gccttggcag tgactggaca gctgggtggg ggatgctccc 1186 tgctggccct gggaaccttg gacaggccac ctcaaggccc ctcggctgcc cctcctccct 1246 gggcctgctg gggcccctag gttctgccca ccaccccccg cccctgctgg ccttggtgct 1306 aaggaagtgg ggagagcagg ctctccctgc accgagggtg cccaccctct ccctggtgtg 1366 gccccgtcaa catcagccac agcccagccc cattagtggg ttagtgggtc tgacctcagc 1426 cccactcagg tgctcctgct ggcctgccca agccctgccc tcagggagct tctgcctttt 1486 aagaactggg cagaggccac agtcacctcc ccacacagag ctgtccccac tgccctgggt 1546 gccaggctgt ccggagccag gcctacccag ggaggatgca gagagctggt gcccaggatg 1606 tgcaccccca tattccctct gccctgtggc ctcagcccgc tggcctctct gaccgtgagg 1666 ctggctctca gccatcgggc aggtgcctgg tcgggcctgg cttagcccag gtggggtttg 1726 gcagaagcgg gcgggtgtgg aagatattcc atctggggcc aaccccaggc tgggcctgcg 1786 ctgagcttct ggagcgcagg tactgggtct tgctaagtga actgtttccc aggaacacct 1846 ctcgggccca tctgcgtctg aggctgggag tggcatctga ggccgggagt ggcatctgag 1906 gccaggagtg gcaggctggt gggctgggcg tggggttttc tgggccctgc ccagtactgc 1966 cctggggact tggtgggctc ctgggtcagc agcatcccac ccctgggagt ctggccagct 2026 gagccccagg gtggcagggg cattatagcc tggtggacat gtgccttcag ggttcctccg 2086 gggccacctt cctcaggcca gtgctgggtt caaagggctg tgtgtgtgtg tgtgtgtgtg 2146 tgtgtgtgtg tatgtatatg tgtgtgggtg cacacatctg tcccatgtat gcagtgagac 2206 ctgtctacct cccacaagga gcaagggctc tgcccgccct ctgctcattc ctacccaggt 2266 agtgggaccc cgggccccct tctgcctggc ttgcctgctt ctgccctttc cagaggggtc 2326 tcactgacag ccagagacag caggagaagg gttggctgtg gatcaaggaa ggctgcccct 2386 gtaccctgtg gggaaatggt gggtgcatgg ctggatgcag aggtggaagg ccctgggcca 2446 caggcgagag tgggcgtgtc acctgtccca ggttcccagc aagtctgcag ctgtgcagtc 2506 ctggggtccc tgaccctgtc gcccaggggg cgtgctgtcc agcaggggcc ctgccttgca 2566 aggaacgtct cttccggcgg ctgggccgct cctgcctggt ctgggctgtg tgtggcgccc 2626 tttcctcctt gtttgttcct ctgtgttctg tgtgcgtctt aagcaataaa gcgtggccgt 2686 ggctcgcg 2694 <210> 284 <211> 172 <212> PRT <213> Homo sapiens <400> 284 Met Ser Ser Ser Gly Gly Ala Pro Gly Ala Ser Ala Ser Ser Ala Pro 1 5 10 15 Pro Ala Gln Glu Glu Gly Met Thr Trp Trp Tyr Arg Trp Leu Cys Arg 20 25 30 Leu Ser Gly Val Leu Gly Ala Val Ser Cys Ala Ile Ser Gly Leu Phe 35 40 45 Asn Cys Ile Thr Ile His Pro Leu Asn Ile Ala Ala Gly Val Trp Met 50 55 60 Ile Met Asn Ala Phe Ile Leu Leu Leu Cys Glu Ala Pro Phe Cys Cys 65 70 75 80 Gln Phe Ile Glu Phe Ala Asn Thr Val Ala Glu Lys Val Asp Arg Leu 85 90 95 Arg Ser Trp Gln Lys Ala Val Phe Tyr Cys Gly Met Ala Val Val Pro 100 105 110 Ile Val Ile Ser Leu Thr Leu Thr Thr Leu Leu Gly Asn Ala Ile Ala 115 120 125 Phe Ala Thr Gly Val Leu Tyr Gly Leu Ser Ala Leu Gly Lys Lys Gly 130 135 140 Asp Ala Ile Ser Tyr Ala Arg Ile Gln Gln Gln Arg Gln Gln Ala Asp 145 150 155 160 Glu Glu Lys Leu Ala Glu Thr Leu Glu Gly Glu Leu 165 170 <210> 285 <211> 3320 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (163)..(1764) <400> 285 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa attcgggccg ggcctcgctg cggcggcgac 60 tgagccaggc tgggccgcgt ccctgagtcc cagagtcggc gcggcgcggc aggggcagcc 120 ttccaccacg gggagcccag ctgtcagccg cctcacagga ag atg ctg cgt cgg 174 Met Leu Arg Arg 1 cgg ggc agc cct ggc atg ggt gtg cat gtg ggt gca gcc ctg gga gca 222 Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala Ala Leu Gly Ala 5 10 15 20 ctg tgg ttc tgc ctc aca gga gcc ctg gag gtc cag gtc cct gaa gac 270 Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln Val Pro Glu Asp 25 30 35 cca gtg gtg gca ctg gtg ggc acc gat gcc acc ctg tgc tgc tcc ttc 318 Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Cys Cys Ser Phe 40 45 50 tcc cct gag cct ggc ttc agc ctg gca cag ctc aac ctc atc tgg cag 366 Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln 55 60 65 ctg aca gat acc aaa cag ctg gtg cac agc ttt gct gag ggc cag gac 414 Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala Glu Gly Gln Asp 70 75 80 cag ggc agc gcc tat gcc aac cgc acg gcc ctc ttc ccg gac ctg ctg 462 Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu 85 90 95 100 gca cag ggc aac gca tcc ctg agg ctg cag cgc gtg cgt gtg gcg gac 510 Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp 105 110 115 gag ggc agc ttc acc tgc ttc gtg agc atc cgg gat ttc ggc agc gct 558 Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala 120 125 130 gcc gtc agc ctg cag gtg gcc gct ccc tac tcg aag ccc agc atg acc 606 Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr 135 140 145 ctg gag ccc aac aag gac ctg cgg cca ggg gac atg gtg acc atc acg 654 Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Met Val Thr Ile Thr 150 155 160 tgc tcc agc tac cag ggc tac cct gag gct gag gtg ttc tgg cag gat 702 Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp 165 170 175 180 ggg cag ggt gtg ccc ctg act ggc aac gtg acc acg tcg cag atg gcc 750 Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala 185 190 195 aac gag cag ggc ttg ttt gat gtg cac agc atc ctg cgg gtg gtg ctg 798 Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu Arg Val Val Leu 200 205 210 ggt gca aat ggc acc tac agc tgc ctg gtg cgc aac ccc gtg ctg cag 846 Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln 215 220 225 cag gat gcg cac agc tct gtc acc atc aca ccc cag aga agc ccc aca 894 Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln Arg Ser Pro Thr 230 235 240 gga gcc gtg gag gtc cag gtc cct gag gac ccg gtg gtg gcc cta gtg 942 Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val 245 250 255 260 ggc acc gat gcc acc ctg cgc tgc tcc ttc tcc ccc gag cct ggc ttc 990 Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro Glu Pro Gly Phe 265 270 275 agc ctg gca cag ctc aac ctc atc tgg cag ctg aca gac acc aaa cag 1038 Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln 280 285 290 ctg gtg cac agt ttc acc gaa ggc cgg gac cag ggc agc gcc tat gcc 1086 Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly Ser Ala Tyr Ala 295 300 305 aac cgc acg gcc ctc ttc ccg gac ctg ctg gca caa ggc aat gca tcc 1134 Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser 310 315 320 ctg agg ctg cag cgc gtg cgt gtg gcg gac gag ggc agc ttc acc tgc 1182 Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys 325 330 335 340 ttc gtg agc atc cgg gat ttc ggc agc gct gcc gtc agc ctg cag gtg 1230 Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val 345 350 355 gcc gct ccc tac tcg aag ccc agc atg acc ctg gag ccc aac aag gac 1278 Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp 360 365 370 ctg cgg cca ggg gac acg gtg acc atc acg tgc tcc agc tac cgg ggc 1326 Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly 375 380 385 tac cct gag gct gag gtg ttc tgg cag gat ggg cag ggt gtg ccc ctg 1374 Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu 390 395 400 act ggc aac gtg acc acg tcg cag atg gcc aac gag cag ggc ttg ttt 1422 Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe 405 410 415 420 gat gtg cac agc gtc ctg cgg gtg gtg ctg ggt gcg aat ggc acc tac 1470 Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr 425 430 435 agc tgc ctg gtg cgc aac ccc gtg ctg cag cag gat gcg cac ggc tct 1518 Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Gly Ser 440 445 450 gtc acc atc aca ggg cag cct atg aca ttc ccc cca gag gcc ctg tgg 1566 Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro Glu Ala Leu Trp 455 460 465 gtg acc gtg ggg ctg tct gtc tgt ctc att gca ctg ctg gtg gcc ctg 1614 Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu Leu Val Ala Leu 470 475 480 gct ttc gtg tgc tgg aga aag atc aaa cag agc tgt gag gag gag aat 1662 Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn 485 490 495 500 gca gga gct gag gac cag gat ggg gag gga gaa ggc tcc aag aca gcc 1710 Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala 505 510 515 ctg cag cct ctg aaa cac tct gac agc aaa gaa gat gat gga caa gaa 1758 Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu 520 525 530 ata gcc tgaccatgag gaccagggag ctgctacccc tccctacagc tcctaccctc 1814 Ile Ala tggctgcaat ggggctgcac tgtgagccct gcccccaaca gatgcatcct gctctgacag 1874 gtgggctcct tctccaaagg atgcgataca cagaccactg tgcagcctta tttctccaat 1934 ggacatgatt cccaagtcat cctgctgcct tttttcttat agacacaatg aacagaccac 1994 ccacaacctt agttctctaa gtcatcctgc ctgctgcctt atttcacagt acatacattt 2054 cttagggaca cagtacactg accacatcac caccctcttc ttccagtgct gcgtggacca 2114 tctggctgcc ttttttctcc aaaagatgca atattcagac tgactgaccc cctgccttat 2174 ttcaccaaag acacgatgca tagtcacccc ggccttgttt ctccaatggc cgtgatacac 2234 tagtgatcat gttcagccct gcttccacct gcatagaatc ttttcttctc agacagggac 2294 agtgcggcct caacatctcc tggagtctag aagctgtttc ctttcccctc cttcctcctc 2354 ttgctctagc cttaatactg gccttttccc tccctgcccc aagtgaagac agggcactct 2414 gcgcccacca catgcacagc tgtgcatgga gacctgcagg tgcacgtgct ggaacacgtg 2474 tggttccccc ctggcccagc ctcctctgca gtgcccctct cccctgccca tcctccccac 2534 ggaagcatgt gctggtcaca ctggttctcc aggggtctgt gatggggccc ctgggggtca 2594 gcttctgtcc ctctgccttc tcacctcttt gttcctttct tttcatgtat ccattcagtt 2654 gatgtttatt gagcaactac agatgtcagc actgtgttag gtgctggggg ccctgcgtgg 2714 gaagataaag ttcctccctc aaggactccc catccagctg ggagacagac aactaactac 2774 actgcaccct gcggtttgca gggggctcct gcctggctcc ctgctccaca cctcctctgt 2834 ggctcaaggc ttcctggata cctcaccccc atcccaccca taattcttac ccagagcatg 2894 gggttggggc ggaaacctgg agagagggac atagcccctc gccacggcta gagaatctgg 2954 tggtgtccaa aatgtctgtc caggtgtggg caggtgggca ggcaccaagg ccctctggac 3014 ctttcatagc agcagaaaag gcagagcctg gggcagggca gggccaggaa tgctttgggg 3074 acaccgaggg gactgccccc cacccccacc atggtgctat tctggggctg gggcagtctt 3134 ttcctggctt gcctctggcc agctcctggc ctctggtaga gtgagacttc agacgttctg 3194 atgccttccg gatgtcatct ctccctgccc caggaatgga agatgtgagg acttctaatt 3254 taaatgtggg actcggaggg attttgtaaa ctgggggtat attttgggga aaataaatgt 3314 ctttgt 3320 <210> 286 <211> 534 <212> PRT <213> Homo sapiens <400> 286 Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 1 5 10 15 Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 20 25 30 Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 35 40 45 Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 50 55 60 Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 65 70 75 80 Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 85 90 95 Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 100 105 110 Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 115 120 125 Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 130 135 140 Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Met 145 150 155 160 Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 165 170 175 Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 180 185 190 Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 195 200 205 Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 210 215 220 Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 225 230 235 240 Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 245 250 255 Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 260 265 270 Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 275 280 285 Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 290 295 300 Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 305 310 315 320 Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 325 330 335 Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 340 345 350 Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 355 360 365 Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 370 375 380 Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 385 390 395 400 Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 405 410 415 Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 420 425 430 Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 435 440 445 Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 450 455 460 Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 465 470 475 480 Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 485 490 495 Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 500 505 510 Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 515 520 525 Asp Gly Gln Glu Ile Ala 530 <210> 287 <211> 2179 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (192)..(860) <400> 287 ctctttaagg tgcccgaggc tcgcgggcgc tgcgctgagg ggacggcggg aggcgcggcc 60 tggcctcgca ctcaaagccg ccgcagcgcg ccccgggctc ggccgacccg gcggggatct 120 aggggtgggc gacttcgcgg gaccgtggcg catgtttcct gggagttact gatcatcttc 180 tttgaagaaa c atg aag tta cac tat gtt gct gtg ctt act cta gcc atc 230 Met Lys Leu His Tyr Val Ala Val Leu Thr Leu Ala Ile 1 5 10 ctg atg ttc ctg aca tgg ctt cca gaa tca ctg agc tgt aac aaa gca 278 Leu Met Phe Leu Thr Trp Leu Pro Glu Ser Leu Ser Cys Asn Lys Ala 15 20 25 ctc tgt gct agt gat gag agc aaa tgc ctc att cag gag ctc tgc cag 326 Leu Cys Ala Ser Asp Glu Ser Lys Cys Leu Ile Gln Glu Leu Cys Gln 30 35 40 45 tgc cgg ccg gga gaa ggc aat tgc tcc tgc tgt aag gag tgc atg ctg 374 Cys Arg Pro Gly Glu Gly Asn Cys Ser Cys Cys Lys Glu Cys Met Leu 50 55 60 tgt ctt ggg gcc ctt tgg gac gag tgc tgt gac tgt gtt ggt atg tgt 422 Cys Leu Gly Ala Leu Trp Asp Glu Cys Cys Asp Cys Val Gly Met Cys 65 70 75 aat cct cga aat tat agt gac aca cct cca act tca aag agc aca gtg 470 Asn Pro Arg Asn Tyr Ser Asp Thr Pro Pro Thr Ser Lys Ser Thr Val 80 85 90 gag gag ctg cat gaa ccg atc cct tct ctc ttc cgg gca ctc aca gaa 518 Glu Glu Leu His Glu Pro Ile Pro Ser Leu Phe Arg Ala Leu Thr Glu 95 100 105 gga gat act cag ttg aat tgg aac atc gtt tct ttc cct gtt gca gaa 566 Gly Asp Thr Gln Leu Asn Trp Asn Ile Val Ser Phe Pro Val Ala Glu 110 115 120 125 gaa ctt tca cat cat gag aat ctg gtt tca ttt tta gaa act gtg aac 614 Glu Leu Ser His His Glu Asn Leu Val Ser Phe Leu Glu Thr Val Asn 130 135 140 cag cca cac cac cag aat gtg tct gtc ccc agc aat aat gtt cac gcg 662 Gln Pro His His Gln Asn Val Ser Val Pro Ser Asn Asn Val His Ala 145 150 155 cct tat tcc agt gac aaa gaa cac atg tgt act gtg gtt tat ttt gat 710 Pro Tyr Ser Ser Asp Lys Glu His Met Cys Thr Val Val Tyr Phe Asp 160 165 170 gac tgc atg tcc ata cat cag tgt aaa ata tcc tgt gag tcc atg gga 758 Asp Cys Met Ser Ile His Gln Cys Lys Ile Ser Cys Glu Ser Met Gly 175 180 185 gca tcc aaa tat cgc tgg ttt cat aat gcc tgc tgc gag tgc att ggt 806 Ala Ser Lys Tyr Arg Trp Phe His Asn Ala Cys Cys Glu Cys Ile Gly 190 195 200 205 cca gaa tgt att gac tat ggt agt aaa act gtc aaa tgt atg aac tgc 854 Pro Glu Cys Ile Asp Tyr Gly Ser Lys Thr Val Lys Cys Met Asn Cys 210 215 220 atg ttt taaagaagac aaatgcaaac caaagcaact tagtaaaata ataggtataa 910 Met Phe agagttattc tgtaagtctg ttggttgtat cttgtatcag aatcccagta agttaagttg 970 taaagacttt ggaataagtt tcttttaaaa atatgacata gccagtgatg tgtttaatta 1030 tataactgtt cttactgatt ttattgcccc ctagcaataa gccctttcct ttgaatacat 1090 gtacaacttt ggtcatatga gaagcaggtg cgcagagaat tccttgaaag atctgaggtt 1150 tttaacataa agtctgatgt ggttttcctc tagcattcca aaaggttttt gctttgaaag 1210 tgttagcaga agcatgttga tgtgaattat gatttcttca tgtgctactg ttagcacact 1270 gagtttttat agttgcacat cattcctcat tgtgccttgt tttatccatt ttataaatag 1330 agtagatatt tgatatacca ctctgataac tcatataaaa atatcatcat aaaaaactta 1390 atttcatccc ttttatgttg gttttaaaag gtaaatgctt accatatttt ataattgaga 1450 actcttacat agtagaatcc attctataat acatgtgttg acaaagcttt agagaaagtt 1510 tcctattctc ttccatttcc cctgcccaaa gtgctgacat aggcagtgat gaagaatctt 1570 taccaagatt ttcagggtgt acctatgaaa ttgctttaaa tgcactgctg gtgtaaataa 1630 ttagcaagca aaagcgtttc tgtgacttca ggtaccagct taaagagcac tagggatggg 1690 gaacgaatgc caaatcagac tccacctaga gcaccaggaa acagcttgta ccctggtagg 1750 gaaatggtgt cgctgaaagg ggaggctgag ccagtgcgag actgaacttg tgcagcctta 1810 gccaagacaa agcagtgttt ttcagcagac ggctgatggg acaggaattg aagaagagaa 1870 ttgactcgta tgaacaggac agggtgaaaa tgctgggaat tataatggga aacaaaacta 1930 tctatgttca tattttgtaa tatttcattt gttaagttta tatctggata taatgttctt 1990 tttaaacaag tataatcata tcgtcggagg ttaagattat gaaattttaa aatctctatt 2050 caagatgatg ttcactccaa atacactaca gaatttagtc aacattttat ataatgtttc 2110 aataaatgtt tctttcaata aagatactat gtgcccttca tagtaataaa atctcaatct 2170 taaagcatg 2179 <210> 288 <211> 223 <212> PRT <213> Homo sapiens <400> 288 Met Lys Leu His Tyr Val Ala Val Leu Thr Leu Ala Ile Leu Met Phe 1 5 10 15 Leu Thr Trp Leu Pro Glu Ser Leu Ser Cys Asn Lys Ala Leu Cys Ala 20 25 30 Ser Asp Glu Ser Lys Cys Leu Ile Gln Glu Leu Cys Gln Cys Arg Pro 35 40 45 Gly Glu Gly Asn Cys Ser Cys Cys Lys Glu Cys Met Leu Cys Leu Gly 50 55 60 Ala Leu Trp Asp Glu Cys Cys Asp Cys Val Gly Met Cys Asn Pro Arg 65 70 75 80 Asn Tyr Ser Asp Thr Pro Pro Thr Ser Lys Ser Thr Val Glu Glu Leu 85 90 95 His Glu Pro Ile Pro Ser Leu Phe Arg Ala Leu Thr Glu Gly Asp Thr 100 105 110 Gln Leu Asn Trp Asn Ile Val Ser Phe Pro Val Ala Glu Glu Leu Ser 115 120 125 His His Glu Asn Leu Val Ser Phe Leu Glu Thr Val Asn Gln Pro His 130 135 140 His Gln Asn Val Ser Val Pro Ser Asn Asn Val His Ala Pro Tyr Ser 145 150 155 160 Ser Asp Lys Glu His Met Cys Thr Val Val Tyr Phe Asp Asp Cys Met 165 170 175 Ser Ile His Gln Cys Lys Ile Ser Cys Glu Ser Met Gly Ala Ser Lys 180 185 190 Tyr Arg Trp Phe His Asn Ala Cys Cys Glu Cys Ile Gly Pro Glu Cys 195 200 205 Ile Asp Tyr Gly Ser Lys Thr Val Lys Cys Met Asn Cys Met Phe 210 215 220 <210> 289 <211> 2617 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (306)..(1778) <400> 289 gcgaatgcga acctggcccg tgcggaaagg gcgcggagag ccccggcgcg gagcaggcgg 60 gggacggtat tcagaattcg agcgcaggag ctccgcttct ccacctgctc ccggggagct 120 attgggatcc agagaatcac ccgctgatgg tttttgccca ggcctgaaac aaccagagag 180 ctacgggaaa ggaagggctt ggcttgccag aggaattttc caagtgctca aacgccaggc 240 ttacggcgcc tgtgatccgt ccaggaggac aaagtgggat ttgaaggtcc actccacttc 300 tgctc atg gcg ggc cag ggc ctg ccc ctg cac gtg gcc aca ctg ctg act 350 Met Ala Gly Gln Gly Leu Pro Leu His Val Ala Thr Leu Leu Thr 1 5 10 15 ggg ctg ctg gaa tgc ctg ggc ttt gct ggc gtc ctc ttt ggc tgg cct 398 Gly Leu Leu Glu Cys Leu Gly Phe Ala Gly Val Leu Phe Gly Trp Pro 20 25 30 tca cta gtg ttt gtc ttc aag aat gaa gat tac ttt aag gat ctg tgt 446 Ser Leu Val Phe Val Phe Lys Asn Glu Asp Tyr Phe Lys Asp Leu Cys 35 40 45 gga cca gat gct ggg ccg att ggc aat gcc aca ggg cag gct gac tgc 494 Gly Pro Asp Ala Gly Pro Ile Gly Asn Ala Thr Gly Gln Ala Asp Cys 50 55 60 aaa gcc cag gat gag agg ttc tca ctc atc ttc acc ctg ggg tcc ttc 542 Lys Ala Gln Asp Glu Arg Phe Ser Leu Ile Phe Thr Leu Gly Ser Phe 65 70 75 atg aac aac ttc atg aca ttc ccc act ggc tac atc ttt gac cgg ttc 590 Met Asn Asn Phe Met Thr Phe Pro Thr Gly Tyr Ile Phe Asp Arg Phe 80 85 90 95 aag acc acc gtg gca cgc ctc ata gcc ata ttt ttc tac acc acc gcc 638 Lys Thr Thr Val Ala Arg Leu Ile Ala Ile Phe Phe Tyr Thr Thr Ala 100 105 110 aca ctc atc ata gcc ttc acc tct gca ggc tca gcc gtg ctg ctc ttc 686 Thr Leu Ile Ile Ala Phe Thr Ser Ala Gly Ser Ala Val Leu Leu Phe 115 120 125 ctg gcc atg cca atg ctc acc att ggg gga atc ctg ttt ctc atc acc 734 Leu Ala Met Pro Met Leu Thr Ile Gly Gly Ile Leu Phe Leu Ile Thr 130 135 140 aac ctg cag att ggg aac cta ttt ggc caa cac cgt tcg acc atc atc 782 Asn Leu Gln Ile Gly Asn Leu Phe Gly Gln His Arg Ser Thr Ile Ile 145 150 155 act ctg tac aat gga gca ttt gac tct tcc tcg gca gtc ttc ctt att 830 Thr Leu Tyr Asn Gly Ala Phe Asp Ser Ser Ser Ala Val Phe Leu Ile 160 165 170 175 att aag ctt ctt tat gaa aaa ggc atc agc ctc agg gcc tcc ttc atc 878 Ile Lys Leu Leu Tyr Glu Lys Gly Ile Ser Leu Arg Ala Ser Phe Ile 180 185 190 ttc atc tct gtc tgc agt acc tgg cat gta gca cgc act ttc ctc ctg 926 Phe Ile Ser Val Cys Ser Thr Trp His Val Ala Arg Thr Phe Leu Leu 195 200 205 atg ccc cgg ggg cac atc cca tac cca ctg ccc ccc aac tac agc tat 974 Met Pro Arg Gly His Ile Pro Tyr Pro Leu Pro Pro Asn Tyr Ser Tyr 210 215 220 ggc ctg tgc cct ggg aat ggc acc aca aag gaa gag aag gaa aca gct 1022 Gly Leu Cys Pro Gly Asn Gly Thr Thr Lys Glu Glu Lys Glu Thr Ala 225 230 235 gag cat gaa aac agg gag cta cag tca aag gag ttc ctt tca gcg aag 1070 Glu His Glu Asn Arg Glu Leu Gln Ser Lys Glu Phe Leu Ser Ala Lys 240 245 250 255 gaa gag acc cca ggg gca ggg cag aag cag gaa ctc cgc tcc ttc tgg 1118 Glu Glu Thr Pro Gly Ala Gly Gln Lys Gln Glu Leu Arg Ser Phe Trp 260 265 270 agc tac gct ttc tct cgg cgc ttt gcc tgg cac ctg gtg tgg ctg tct 1166 Ser Tyr Ala Phe Ser Arg Arg Phe Ala Trp His Leu Val Trp Leu Ser 275 280 285 gtg ata cag ttg tgg cac tac ctc ttc att ggc act ctc aac tcc ttg 1214 Val Ile Gln Leu Trp His Tyr Leu Phe Ile Gly Thr Leu Asn Ser Leu 290 295 300 ctg acc aac atg gcc ggt ggg gac atg gca cga gtc agc acc tac aca 1262 Leu Thr Asn Met Ala Gly Gly Asp Met Ala Arg Val Ser Thr Tyr Thr 305 310 315 aat gcc ttt gcc ttc act cag ttc gga gtg ctg tgt gcc ccc tgg aat 1310 Asn Ala Phe Ala Phe Thr Gln Phe Gly Val Leu Cys Ala Pro Trp Asn 320 325 330 335 ggc ctg ctc atg gac cgg ctt aaa cag aag tac cag aag gaa gca aga 1358 Gly Leu Leu Met Asp Arg Leu Lys Gln Lys Tyr Gln Lys Glu Ala Arg 340 345 350 aag aca ggt tcc tcc act ttg gcg gtg gcc ctc tgc tcg acg gtg cct 1406 Lys Thr Gly Ser Ser Thr Leu Ala Val Ala Leu Cys Ser Thr Val Pro 355 360 365 tcg ctg gcc ctg aca tcc ctg ctg tgc ctg ggc ttc gcc ctc tgt gcc 1454 Ser Leu Ala Leu Thr Ser Leu Leu Cys Leu Gly Phe Ala Leu Cys Ala 370 375 380 tca gtc ccc atc ctc cct ctc cag tac ctc acc ttc atc ctg caa gtg 1502 Ser Val Pro Ile Leu Pro Leu Gln Tyr Leu Thr Phe Ile Leu Gln Val 385 390 395 atc agc cgc tcc ttc ctc tat ggg agc aac gcg gcc ttc ctc acc ctt 1550 Ile Ser Arg Ser Phe Leu Tyr Gly Ser Asn Ala Ala Phe Leu Thr Leu 400 405 410 415 gct ttc cct tca gag cac ttt ggc aag ctc ttt ggg ctg gtg atg gcc 1598 Ala Phe Pro Ser Glu His Phe Gly Lys Leu Phe Gly Leu Val Met Ala 420 425 430 ttg tcg gct gtg gtg tct ctg ctc cag ttc ccc atc ttc acc ctc atc 1646 Leu Ser Ala Val Val Ser Leu Leu Gln Phe Pro Ile Phe Thr Leu Ile 435 440 445 aaa ggc tcc ctt cag aat gac cca ttt tac gtg gat gtg atg ttc atg 1694 Lys Gly Ser Leu Gln Asn Asp Pro Phe Tyr Val Asp Val Met Phe Met 450 455 460 ctt gcc att ctt ctg aca ttc ttc cac ccc ttt ctg gta tat cgg gaa 1742 Leu Ala Ile Leu Leu Thr Phe Phe His Pro Phe Leu Val Tyr Arg Glu 465 470 475 tgc cgt act tgg aaa gaa agt ccc tct gca att gca tagttcagaa 1788 Cys Arg Thr Trp Lys Glu Ser Pro Ser Ala Ile Ala 480 485 490 gccctcactt ttcagccccg aggatggttt tgttcatctt ccaccacctt tgaggacctc 1848 gtgtcccaaa agactttgcc tatcccagca aaacacacac acacacacac acacacacaa 1908 aataaagaca cacaaggacg tctgcgcagc aagaaaagaa tctcagttgc caagcagatt 1968 gatatcacac agactcaaag caaaggcatg tggaacttct ttatttcaaa acagaagtgt 2028 ctccttgcac ttagccttgg cagacccttg actccagggg agatgacctg ggggaggaag 2088 tgtgtcaact atttctttag gcctgtttgg ctccgaagcc tatatgtgcc tggatcctct 2148 gccacgggtt aaattttcag gtgaagagtg aggttgtcat ggcctcagct atgcttcctg 2208 gctctccctc aagagtgcag ccttggctag agaactcaca gctctgggaa aaagaggagc 2268 agacagggtt ccctgggccc agtctcagcc cagccactga tgctggatga ccttggcctg 2328 accctggtct ggtctcagaa tcacttttcc catctgtaaa attgagatga attttggtgt 2388 tgaaagttct tcctggagca gatgtcctag aaggttttag gaatagtgac agagtcaggc 2448 caccccaagg gccatgggag ccagctgacc tgcttgaccg aaggatttct gacagactat 2508 ctttggggat gttttcaaga agggatataa gttatttact ttgggcattt aaaagaaaat 2568 ttctctcggg aataatttta tagaaaaata aagcttctgt gtctaaggc 2617 <210> 290 <211> 491 <212> PRT <213> Homo sapiens <400> 290 Met Ala Gly Gln Gly Leu Pro Leu His Val Ala Thr Leu Leu Thr Gly 1 5 10 15 Leu Leu Glu Cys Leu Gly Phe Ala Gly Val Leu Phe Gly Trp Pro Ser 20 25 30 Leu Val Phe Val Phe Lys Asn Glu Asp Tyr Phe Lys Asp Leu Cys Gly 35 40 45 Pro Asp Ala Gly Pro Ile Gly Asn Ala Thr Gly Gln Ala Asp Cys Lys 50 55 60 Ala Gln Asp Glu Arg Phe Ser Leu Ile Phe Thr Leu Gly Ser Phe Met 65 70 75 80 Asn Asn Phe Met Thr Phe Pro Thr Gly Tyr Ile Phe Asp Arg Phe Lys 85 90 95 Thr Thr Val Ala Arg Leu Ile Ala Ile Phe Phe Tyr Thr Thr Ala Thr 100 105 110 Leu Ile Ile Ala Phe Thr Ser Ala Gly Ser Ala Val Leu Leu Phe Leu 115 120 125 Ala Met Pro Met Leu Thr Ile Gly Gly Ile Leu Phe Leu Ile Thr Asn 130 135 140 Leu Gln Ile Gly Asn Leu Phe Gly Gln His Arg Ser Thr Ile Ile Thr 145 150 155 160 Leu Tyr Asn Gly Ala Phe Asp Ser Ser Ser Ala Val Phe Leu Ile Ile 165 170 175 Lys Leu Leu Tyr Glu Lys Gly Ile Ser Leu Arg Ala Ser Phe Ile Phe 180 185 190 Ile Ser Val Cys Ser Thr Trp His Val Ala Arg Thr Phe Leu Leu Met 195 200 205 Pro Arg Gly His Ile Pro Tyr Pro Leu Pro Pro Asn Tyr Ser Tyr Gly 210 215 220 Leu Cys Pro Gly Asn Gly Thr Thr Lys Glu Glu Lys Glu Thr Ala Glu 225 230 235 240 His Glu Asn Arg Glu Leu Gln Ser Lys Glu Phe Leu Ser Ala Lys Glu 245 250 255 Glu Thr Pro Gly Ala Gly Gln Lys Gln Glu Leu Arg Ser Phe Trp Ser 260 265 270 Tyr Ala Phe Ser Arg Arg Phe Ala Trp His Leu Val Trp Leu Ser Val 275 280 285 Ile Gln Leu Trp His Tyr Leu Phe Ile Gly Thr Leu Asn Ser Leu Leu 290 295 300 Thr Asn Met Ala Gly Gly Asp Met Ala Arg Val Ser Thr Tyr Thr Asn 305 310 315 320 Ala Phe Ala Phe Thr Gln Phe Gly Val Leu Cys Ala Pro Trp Asn Gly 325 330 335 Leu Leu Met Asp Arg Leu Lys Gln Lys Tyr Gln Lys Glu Ala Arg Lys 340 345 350 Thr Gly Ser Ser Thr Leu Ala Val Ala Leu Cys Ser Thr Val Pro Ser 355 360 365 Leu Ala Leu Thr Ser Leu Leu Cys Leu Gly Phe Ala Leu Cys Ala Ser 370 375 380 Val Pro Ile Leu Pro Leu Gln Tyr Leu Thr Phe Ile Leu Gln Val Ile 385 390 395 400 Ser Arg Ser Phe Leu Tyr Gly Ser Asn Ala Ala Phe Leu Thr Leu Ala 405 410 415 Phe Pro Ser Glu His Phe Gly Lys Leu Phe Gly Leu Val Met Ala Leu 420 425 430 Ser Ala Val Val Ser Leu Leu Gln Phe Pro Ile Phe Thr Leu Ile Lys 435 440 445 Gly Ser Leu Gln Asn Asp Pro Phe Tyr Val Asp Val Met Phe Met Leu 450 455 460 Ala Ile Leu Leu Thr Phe Phe His Pro Phe Leu Val Tyr Arg Glu Cys 465 470 475 480 Arg Thr Trp Lys Glu Ser Pro Ser Ala Ile Ala 485 490 <210> 291 <211> 2872 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (88)..(882) <400> 291 agcagcgcag gtgagcgccg cttccggggt cgggcgcctg gatagctgcc ggctccggct 60 tccacttggt cggttgcgcg ggagact atg gcg tcc tcc tcg gtc cca cca gcc 114 Met Ala Ser Ser Ser Val Pro Pro Ala 1 5 acg gta tcg gcg gcg aca gca ggc ccc ggc cca ggt ttc ggc ttc gcc 162 Thr Val Ser Ala Ala Thr Ala Gly Pro Gly Pro Gly Phe Gly Phe Ala 10 15 20 25 tcc aag acc aag aag aag cat ttc gtg cag cag aag gtg aag gtg ttc 210 Ser Lys Thr Lys Lys Lys His Phe Val Gln Gln Lys Val Lys Val Phe 30 35 40 cgg gcg gcc gac ccg ctg gtg ggt gtg ttc ctg tgg ggc gta gcc cac 258 Arg Ala Ala Asp Pro Leu Val Gly Val Phe Leu Trp Gly Val Ala His 45 50 55 tcg atc aat gag ctc agc cag gtg cct ccc ccg gtg atg ctg ctg cca 306 Ser Ile Asn Glu Leu Ser Gln Val Pro Pro Pro Val Met Leu Leu Pro 60 65 70 gat gac ttt aag gcc agc tcc aag atc aag gtc aac aat cac ctt ttc 354 Asp Asp Phe Lys Ala Ser Ser Lys Ile Lys Val Asn Asn His Leu Phe 75 80 85 cac agg gaa aat ctg ccc agt cat ttc aag ttc aag gag tat tgt ccc 402 His Arg Glu Asn Leu Pro Ser His Phe Lys Phe Lys Glu Tyr Cys Pro 90 95 100 105 cag gtc ttc agg aac ctc cgt gat cga ttt ggc att gat gac caa gat 450 Gln Val Phe Arg Asn Leu Arg Asp Arg Phe Gly Ile Asp Asp Gln Asp 110 115 120 tac ttg gtg tcc ctt acc cga aac ccc ccc agc gaa agt gaa ggc agt 498 Tyr Leu Val Ser Leu Thr Arg Asn Pro Pro Ser Glu Ser Glu Gly Ser 125 130 135 gat ggt cgc ttc ctt atc tcc tac gat cgg act ctg gtc atc aaa gaa 546 Asp Gly Arg Phe Leu Ile Ser Tyr Asp Arg Thr Leu Val Ile Lys Glu 140 145 150 gta tcc agt gag gac att gct gac atg cat agc aac ctc tcc aac tat 594 Val Ser Ser Glu Asp Ile Ala Asp Met His Ser Asn Leu Ser Asn Tyr 155 160 165 cac cag tac att gtg aag tgc cat ggc aac acg ctt ctg ccc cag ttc 642 His Gln Tyr Ile Val Lys Cys His Gly Asn Thr Leu Leu Pro Gln Phe 170 175 180 185 ctg ggg atg tac cga gtc agt gtg gac aac gaa gac agc tac atg ctt 690 Leu Gly Met Tyr Arg Val Ser Val Asp Asn Glu Asp Ser Tyr Met Leu 190 195 200 gtg atg cgc aat atg ttt agc cac cgt ctt cct gtg cac agg aag tat 738 Val Met Arg Asn Met Phe Ser His Arg Leu Pro Val His Arg Lys Tyr 205 210 215 gac ctc aag ggt tcc cta gtg tcc cgg gag cca gcg ata agg aaa agg 786 Asp Leu Lys Gly Ser Leu Val Ser Arg Glu Pro Ala Ile Arg Lys Arg 220 225 230 tta aag aat tgc cca ccc tta agg ata tgg act ttc tca aca aga acc 834 Leu Lys Asn Cys Pro Pro Leu Arg Ile Trp Thr Phe Ser Thr Arg Thr 235 240 245 aga aag tat ata ttg gtg aag agg aga aga aaa tat ttc tgg aga agc 882 Arg Lys Tyr Ile Leu Val Lys Arg Arg Arg Lys Tyr Phe Trp Arg Ser 250 255 260 265 tgaagagaga tgtggagttt ctagtgcagc tgaagatcac ggactacagc cttctgctag 942 gcatccacga catcattcgg ggctctgaac cagaggagga agcgcccgtg cgggaggatg 1002 agtcagaggt ggatggggac tgcagcctga ctggacctcc tgctctggtg ggctcctatg 1062 gcacctcccc agagggtatc ggaggctaca tccattccca tcggcccctg ggcccaggag 1122 agtttgagtc cttcattgat gtctatgcca tccggagtgc tgaaggagcc ccccagaagg 1182 aggtctactt catgggcctc attgatatcc ttacacagta tgatgccaag aagaaagcag 1242 ctcatgcagc caaaactgtc aagcatgggg ctggggcaga gatctctact gtccatccgg 1302 agcagtatgc taagcgattc ctggatttta ttaccaacat ctttgcctaa gagactgcct 1362 ggttctctct gatgttcaag gagctagggg aagggggttg tttgccttct tcaggacctg 1422 actggacaga tggacctggc tcaagcaact actctggatg cactttgctg tgtgggatga 1482 actaaaagtg tctgaatttt gctgataact ttataaaact cactatggca tgcttccctc 1542 ctggtgggcc ctaggatgga tgacactcaa gatactacag atgtgggtgc aggcatgcac 1602 acacacgatg gaatatggcc attcctacac aggtggggta gagagtgggt cagcagcctg 1662 gcacctcaca gaggtgggac ctaagaggac tcatgattat gcagagaatt ggattgggtc 1722 tctgtcatag attgagtaat ctcttccctt acctcaattc catctccacc catctctaca 1782 tctgggcaca gcaacccaga gatggccaaa agcattcaag cctgggggaa gatgtttgac 1842 tattgctgct cttcaccaga acctcacacc tctcctggga ctggaaccct tcagtgggtg 1902 tgtggccagt tttggaggct ggaatgatgg gccagggtgt aggattcatt ctccatgtaa 1962 agtttccttt catcctgcct agccatcccc aaggtttatt tccagaagaa aggaatatct 2022 ctacttggat caattctggt catttcaaga ggatggaggc ctcaagtgtg ggaacttccc 2082 ctactccctg gatgtgtgta cctagcacac ttccttctcc cacccctttt tccagttgga 2142 tttgtttttc tgttctcttc tgtcctgtct tatactgcaa ctgtgtctcc taggggacag 2202 atggccttct ttgtcatctt cactctccac ccccagaggg gagtcagagc cataactcaa 2262 tcactcagcc cctccaaaga tagttgatgt gtgataatct cataatgttg agaaccctga 2322 tgagatacat tgtcttcctc tccctacaat gcctctgggg ccaaggcacc cattcttctt 2382 gctatcctcc atcccccttg aggcttccac tttttttttt tttagacata aagctgggca 2442 tcagcaactg gcctgtggtg atgcaaagct gctttgctct gtatctggct ggactgatct 2502 gtctcacaag aagccatgag gccataggga gaagctccct ctccccttca tcttctgctc 2562 caaaggtggt agcaagagga gtacccagtt aggggttgga gcccccatat aacatcttcc 2622 tgtcagaaga ctgatggatc tttttcattc caaccatctc cctttccccc gatgaatgca 2682 ataaaactct gtgacaccag caaccattgc tctttagaaa tgggttttct gatcatatgg 2742 ctgatgtgtt atgggcagta tggatgtctt catttgttgc ttctgttttt catctttttt 2802 gttttattaa taaaaattta tgtatttgct cctgttacta taataataca gggaataaat 2862 tattcaatcc 2872 <210> 292 <211> 265 <212> PRT <213> Homo sapiens <400> 292 Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 1 5 10 15 Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 20 25 30 Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 35 40 45 Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 50 55 60 Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 65 70 75 80 Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser 85 90 95 His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg 100 105 110 Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg 115 120 125 Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser 130 135 140 Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala 145 150 155 160 Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys 165 170 175 His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser 180 185 190 Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser 195 200 205 His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val 210 215 220 Ser Arg Glu Pro Ala Ile Arg Lys Arg Leu Lys Asn Cys Pro Pro Leu 225 230 235 240 Arg Ile Trp Thr Phe Ser Thr Arg Thr Arg Lys Tyr Ile Leu Val Lys 245 250 255 Arg Arg Arg Lys Tyr Phe Trp Arg Ser 260 265 <210> 293 <211> 3774 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (268)..(2328) <400> 293 ggactcggca ggcagcgggg accagggctg gcaggttaag cctctggggg tggatcctga 60 aaggtggtcc agccgcctgg ccctgcgtgg gaccctccac ctggcagcag acagggtctc 120 gctctgtcac acaggctgga gtgcagtggt gtgatcttgg ctcatcgtaa cctccacctc 180 ccgggttcaa gtgattctca tgcctcagcc tcccgagtag ctgggattac aggtggtgac 240 ttccaagagt gactccgtcg gaggaaa atg act ccc cag tcg ctg ctg cag acg 294 Met Thr Pro Gln Ser Leu Leu Gln Thr 1 5 aca ctg ttc ctg ctg agt ctg ctc ttc ctg gtc caa ggt gcc cac ggc 342 Thr Leu Phe Leu Leu Ser Leu Leu Phe Leu Val Gln Gly Ala His Gly 10 15 20 25 agg ggc cac agg gaa gac ttt cgc ttc tgc agc cag cgg aac cag aca 390 Arg Gly His Arg Glu Asp Phe Arg Phe Cys Ser Gln Arg Asn Gln Thr 30 35 40 cac agg agc agc ctc cac tac aaa ccc aca cca gac ctg cgc atc tcc 438 His Arg Ser Ser Leu His Tyr Lys Pro Thr Pro Asp Leu Arg Ile Ser 45 50 55 atc gag aac tcc gaa gag gcc ctc aca gtc cat gcc cct ttc cct gca 486 Ile Glu Asn Ser Glu Glu Ala Leu Thr Val His Ala Pro Phe Pro Ala 60 65 70 gcc cac cct gct tcc cga tcc ttc cct gac ccc agg ggc ctc tac cac 534 Ala His Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His 75 80 85 ttc tgc ctc tac tgg aac cga cat gct ggg aga tta cat ctt ctc tat 582 Phe Cys Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr 90 95 100 105 ggc aag cgt gac ttc ttg ctg agt gac aaa gcc tct agc ctc ctc tgc 630 Gly Lys Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu Cys 110 115 120 ttc cag cac cag gag gag agc ctg gct cag ggc ccc ccg ctg tta gcc 678 Phe Gln His Gln Glu Glu Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala 125 130 135 act tct gtc acc tcc tgg tgg agc cct cag aac atc agc ctg ccc agt 726 Thr Ser Val Thr Ser Trp Trp Ser Pro Gln Asn Ile Ser Leu Pro Ser 140 145 150 gcc gcc agc ttc acc ttc tcc ttc cac agt cct ccc cac acg gcc gct 774 Ala Ala Ser Phe Thr Phe Ser Phe His Ser Pro Pro His Thr Ala Ala 155 160 165 cac aat gcc tcg gtg gac atg tgc gag ctc aaa agg gac ctc cag ctg 822 His Asn Ala Ser Val Asp Met Cys Glu Leu Lys Arg Asp Leu Gln Leu 170 175 180 185 ctc agc cag ttc ctg aag cat ccc cag aag gcc tca agg agg ccc tcg 870 Leu Ser Gln Phe Leu Lys His Pro Gln Lys Ala Ser Arg Arg Pro Ser 190 195 200 gct gcc ccc gcc agc cag cag ttg cag agc ctg gag tcg aaa ctg acc 918 Ala Ala Pro Ala Ser Gln Gln Leu Gln Ser Leu Glu Ser Lys Leu Thr 205 210 215 tct gtg aga ttc atg ggg gac atg gtg tcc ttc gag gag gac cgg atc 966 Ser Val Arg Phe Met Gly Asp Met Val Ser Phe Glu Glu Asp Arg Ile 220 225 230 aac gcc acg gtg tgg aag ctc cag ccc aca gcc ggc ctc cag gac ctg 1014 Asn Ala Thr Val Trp Lys Leu Gln Pro Thr Ala Gly Leu Gln Asp Leu 235 240 245 cac atc cac tcc cgg cag gag gag gag cag agc gag atc atg gag tac 1062 His Ile His Ser Arg Gln Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr 250 255 260 265 tcg gtg ctg ctg cct cga aca ctc ttc cag agg acg aaa ggc cgg agc 1110 Ser Val Leu Leu Pro Arg Thr Leu Phe Gln Arg Thr Lys Gly Arg Ser 270 275 280 ggg gag gct gag aag aga ctc ctc ctg gtg gac ttc agc agc caa gcc 1158 Gly Glu Ala Glu Lys Arg Leu Leu Leu Val Asp Phe Ser Ser Gln Ala 285 290 295 ctg ttc cag gac aag aat tcc agc cac gtc ctg ggt gag aag gtc ttg 1206 Leu Phe Gln Asp Lys Asn Ser Ser His Val Leu Gly Glu Lys Val Leu 300 305 310 ggg att gtg gta cag aac acc aaa gta gcc aac ctc acg gag ccc gtg 1254 Gly Ile Val Val Gln Asn Thr Lys Val Ala Asn Leu Thr Glu Pro Val 315 320 325 gtg ctc acc ttc cag cac cag cta cag ccg aag aat gtg act ctg caa 1302 Val Leu Thr Phe Gln His Gln Leu Gln Pro Lys Asn Val Thr Leu Gln 330 335 340 345 tgt gtg ttc tgg gtt gaa gac ccc aca ttg agc agc ccg ggg cat tgg 1350 Cys Val Phe Trp Val Glu Asp Pro Thr Leu Ser Ser Pro Gly His Trp 350 355 360 agc agt gct ggg tgt gag acc gtc agg agt gaa acc caa aca tcc tgc 1398 Ser Ser Ala Gly Cys Glu Thr Val Arg Ser Glu Thr Gln Thr Ser Cys 365 370 375 ttc tgc aac cac ttg acc tac ttt gca gtg ctg atg gtc tcc tcg gtg 1446 Phe Cys Asn His Leu Thr Tyr Phe Ala Val Leu Met Val Ser Ser Val 380 385 390 gag gtg gac gcc gtg cac aag cac tac ctg agc ctc ctc tcc tac gtg 1494 Glu Val Asp Ala Val His Lys His Tyr Leu Ser Leu Leu Ser Tyr Val 395 400 405 ggc tgt gtc gtc tct gcc ctg gcc tgc ctt gtc acc att gcc gcc tac 1542 Gly Cys Val Val Ser Ala Leu Ala Cys Leu Val Thr Ile Ala Ala Tyr 410 415 420 425 ctc tgc tcc agg agg aaa cct cgg gac tac acc atc aag gtg cac atg 1590 Leu Cys Ser Arg Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val His Met 430 435 440 aac ctg ctg ctg gcc gtc ttc ctg ctg gac acg agc ttc ctg ctc agc 1638 Asn Leu Leu Leu Ala Val Phe Leu Leu Asp Thr Ser Phe Leu Leu Ser 445 450 455 gag ccg gtg gcc ctg aca ggc tct gag gct ggc tgc cga gcc agt gcc 1686 Glu Pro Val Ala Leu Thr Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala 460 465 470 atc ttc ctg cac ttc tcc ctg ctc acc tgc ctt tcc tgg atg ggc ctc 1734 Ile Phe Leu His Phe Ser Leu Leu Thr Cys Leu Ser Trp Met Gly Leu 475 480 485 gag ggg tac aac ctc tac cga ctc gtg gta gag gtc ttt ggc acc tat 1782 Glu Gly Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr Tyr 490 495 500 505 gtc cct ggc tac cta ctc aag ctg agc gcc atg ggc tgg ggc ttc ccc 1830 Val Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro 510 515 520 atc ttt ctg gtg acg ctg gtg gcc ctg gtg gat gtg gac aac tat ggc 1878 Ile Phe Leu Val Thr Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly 525 530 535 ccc atc atc ttg gct gtg cat agg act cca gag ggc gtc atc tac cct 1926 Pro Ile Ile Leu Ala Val His Arg Thr Pro Glu Gly Val Ile Tyr Pro 540 545 550 tcc atg tgc tgg atc cgg gac tcc ctg gtc agc tac atc acc aac ctg 1974 Ser Met Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Thr Asn Leu 555 560 565 ggc ctc ttc agc ctg gtg ttt ctg ttc aac atg gcc atg cta gcc acc 2022 Gly Leu Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Thr 570 575 580 585 atg gtg gtg cag atc ctg cgg ctg cgc ccc cac acc caa aag tgg tca 2070 Met Val Val Gln Ile Leu Arg Leu Arg Pro His Thr Gln Lys Trp Ser 590 595 600 cat gtg ctg aca ctg ctg ggc ctc agc ctg gtc ctt ggc ctg ccc tgg 2118 His Val Leu Thr Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp 605 610 615 gcc ttg atc ttc ttc tcc ttt gct tct ggc acc ttc cag ctt gtc gtc 2166 Ala Leu Ile Phe Phe Ser Phe Ala Ser Gly Thr Phe Gln Leu Val Val 620 625 630 ctc tac ctt ttc agc atc atc acc tcc ttc caa ggc ttc ctc atc ttc 2214 Leu Tyr Leu Phe Ser Ile Ile Thr Ser Phe Gln Gly Phe Leu Ile Phe 635 640 645 atc tgg tac tgg tcc atg cgg ctg cag gcc cgg ggt ggc ccc tcc cct 2262 Ile Trp Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro 650 655 660 665 ctg aag agc aac tca gac agc gcc agg ctc ccc atc agc tcg ggc agc 2310 Leu Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser 670 675 680 acc tcg tcc agc cgc atc taggcctcca gcccacctgc ccatgtgatg 2358 Thr Ser Ser Ser Arg Ile 685 aagcagagat tcggcctcgt cgcacactgc ctgtggcccc cgagcccggc ccagccccag 2418 gccagtcagc cgcagacttt ggaaagccca acgaccatgg agagatgggc cgttgccatg 2478 gtggacggac tcccgggctg ggcttttgaa ttggccttgg ggactactcg gctctcactc 2538 agctcccacg ggactcagaa gtgcgccgcc atgctgccta gggtactgtc cccacatctg 2598 tcccaaccca gctggaggcc tggtctctcc ttacaacccc tgggcccagc cctcattgct 2658 gggggccagg ccttggatct tgagggtctg gcacatcctt aatcctgtgc ccctgcctgg 2718 gacagaaatg tggctccagt tgctctgtct ctcgtggtca ccctgagggc actctgcatc 2778 ctctgtcatt ttaacctcag gtggcaccca gggcgaatgg ggcccagggc agaccttcag 2838 ggccagagcc ctggcggagg agaggccctt tgccaggagc acagcagcag ctcgcctacc 2898 tctgagccca ggccccctcc ctccctcagc cccccagtcc tccctccatc ttccctgggg 2958 ttctcctcct ctcccagggc ctccttgctc cttcgttcac agctgggggt ccccgattcc 3018 aatgctgttt tttggggagt ggtttccagg agctgcctgg tgtctgctgt aaatgtttgt 3078 ctactgcaca agcctcggcc tgcccctgag ccaggctcgg taccgatgcg tgggctgggc 3138 taggtccctc tgtccatctg ggcctttgta tgagctgcat tgcccttgct caccctgacc 3198 aagcacacgc ctcagagggg ccctcagcct ctcctgaagc cctcttgtgg taagaactgt 3258 ggaccatgcc agtcccgtct ggtttccatc ccaccactcc aaggactgag actgacctcc 3318 tctggtgaca ctggcctagg gcctgacact ctcctaagag gttctctcca agcccccaaa 3378 tagctccagg cgccctcggc cgcccatcat ggttaattct gtccaacaaa cacacacggg 3438 tagattgctg gcctgttgta ggtggtaggg acacagatga ccgacctggt cactcctcct 3498 gccaacattc agtctggtat gtgaggcgtg cgtgaagcaa gaactcctgg agctacaggg 3558 acagggagcc atcattcctg cctgggaatc ctggaagact tcctgcagga gtcagcgttc 3618 aatcttgacc ttgaagatgg gaaggatgtt ctttttacgt accaattctt ttgtcttttg 3678 atattaaaaa gaagtacatg ttcattgtag agaatttgga aactgtagaa gagaatcaag 3738 aagaaaaata aaaatcagct gttgtaatca cctagc 3774 <210> 294 <211> 687 <212> PRT <213> Homo sapiens <400> 294 Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 1 5 10 15 Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 20 25 30 Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 35 40 45 Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 50 55 60 Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 65 70 75 80 Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 85 90 95 His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 100 105 110 Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 115 120 125 Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 130 135 140 Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 145 150 155 160 Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 165 170 175 Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 180 185 190 Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 195 200 205 Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 210 215 220 Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 225 230 235 240 Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 245 250 255 Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 260 265 270 Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 275 280 285 Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 290 295 300 Ser His Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 305 310 315 320 Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 325 330 335 Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 340 345 350 Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 355 360 365 Val Arg Ser Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 370 375 380 Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 385 390 395 400 His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 405 410 415 Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Arg Lys Pro 420 425 430 Arg Asp Tyr Thr Ile Lys Val His Met Asn Leu Leu Leu Ala Val Phe 435 440 445 Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu Pro Val Ala Leu Thr Gly 450 455 460 Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile Phe Leu His Phe Ser Leu 465 470 475 480 Leu Thr Cys Leu Ser Trp Met Gly Leu Glu Gly Tyr Asn Leu Tyr Arg 485 490 495 Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu Leu Lys 500 505 510 Leu Ser Ala Met Gly Trp Gly Phe Pro Ile Phe Leu Val Thr Leu Val 515 520 525 Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile Leu Ala Val His 530 535 540 Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser Met Cys Trp Ile Arg Asp 545 550 555 560 Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe 565 570 575 Leu Phe Asn Met Ala Met Leu Ala Thr Met Val Val Gln Ile Leu Arg 580 585 590 Leu Arg Pro His Thr Gln Lys Trp Ser His Val Leu Thr Leu Leu Gly 595 600 605 Leu Ser Leu Val Leu Gly Leu Pro Trp Ala Leu Ile Phe Phe Ser Phe 610 615 620 Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile Ile 625 630 635 640 Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile Trp Tyr Trp Ser Met Arg 645 650 655 Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser 660 665 670 Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile 675 680 685 <210> 295 <211> 3791 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (136)..(1182) <400> 295 acatcctccg gctgcccgcg cacctctcca cgccggcccc gttccgcggc tcgccctcgg 60 ctgcgctcgg ctcccgcggg cgctcggccc cgagcccctc ctccccctac ccgccggccg 120 gacagggagg agcca atg gct ggg cct gcc atc cac acc gct ccc atg ctg 171 Met Ala Gly Pro Ala Ile His Thr Ala Pro Met Leu 1 5 10 ttc ctc gtc ctc ctg ctg ccc ctg gag ctg agc ctg gca ggc gcc ctt 219 Phe Leu Val Leu Leu Leu Pro Leu Glu Leu Ser Leu Ala Gly Ala Leu 15 20 25 gca cct ggg acc cct gcc cgg aac ttc cct gag aat cac att gac ctc 267 Ala Pro Gly Thr Pro Ala Arg Asn Phe Pro Glu Asn His Ile Asp Leu 30 35 40 cca ggc cca gcg ctg tgg acg cct cag gcc agc cac cac cgc cgg cgg 315 Pro Gly Pro Ala Leu Trp Thr Pro Gln Ala Ser His His Arg Arg Arg 45 50 55 60 ggc ccg ggc aag aag gag tgg ggc cca ggc ctg ccc agc cag gcc cag 363 Gly Pro Gly Lys Lys Glu Trp Gly Pro Gly Leu Pro Ser Gln Ala Gln 65 70 75 gat ggg gct gtg gtc acc gcc acc agg cag gcc tcc agg ctg cca gag 411 Asp Gly Ala Val Val Thr Ala Thr Arg Gln Ala Ser Arg Leu Pro Glu 80 85 90 gct gag ggg ctg ctg cct gag cag agt cct gca ggc ctg ctg cag gac 459 Ala Glu Gly Leu Leu Pro Glu Gln Ser Pro Ala Gly Leu Leu Gln Asp 95 100 105 aag gac ctg ctc ctg gga ctg gca ttg ccc tac ccc gag aag gag aac 507 Lys Asp Leu Leu Leu Gly Leu Ala Leu Pro Tyr Pro Glu Lys Glu Asn 110 115 120 cga cct cca ggt tgg gag agg acc agg aaa cgc agc agg gag cac aag 555 Arg Pro Pro Gly Trp Glu Arg Thr Arg Lys Arg Ser Arg Glu His Lys 125 130 135 140 aga cgc agg gac agg ttg agg ctg cac caa ggc cga gcc ttg gtc cga 603 Arg Arg Arg Asp Arg Leu Arg Leu His Gln Gly Arg Ala Leu Val Arg 145 150 155 ggt ccc agc tcc ctg atg aag aag gca gag ctc tcc gaa gcc cag gtg 651 Gly Pro Ser Ser Leu Met Lys Lys Ala Glu Leu Ser Glu Ala Gln Val 160 165 170 ctg gat gca gcc atg gag gaa tcc tcc acc agc ctg gcg ccc acc atg 699 Leu Asp Ala Ala Met Glu Glu Ser Ser Thr Ser Leu Ala Pro Thr Met 175 180 185 ttc ttt ctc acc acc ttt gag gca gca cct gcc aca gaa gag tcc ctg 747 Phe Phe Leu Thr Thr Phe Glu Ala Ala Pro Ala Thr Glu Glu Ser Leu 190 195 200 atc ctg ccc gtc acc tcc ctg cgg ccc cag cag gca cag ccc agg tct 795 Ile Leu Pro Val Thr Ser Leu Arg Pro Gln Gln Ala Gln Pro Arg Ser 205 210 215 220 gac ggg gag gtg atg ccc acg ctg gac atg gcc ttg ttc gac tgg acc 843 Asp Gly Glu Val Met Pro Thr Leu Asp Met Ala Leu Phe Asp Trp Thr 225 230 235 gat tat gaa gac tta aaa cct gat ggt tgg ccc tct gca aag aag aaa 891 Asp Tyr Glu Asp Leu Lys Pro Asp Gly Trp Pro Ser Ala Lys Lys Lys 240 245 250 gag aaa cac cgc ggt aaa ctc tcc agt gat ggt aac gaa aca tca cca 939 Glu Lys His Arg Gly Lys Leu Ser Ser Asp Gly Asn Glu Thr Ser Pro 255 260 265 gcc gaa ggg gaa cca tgc gac cat cac caa gac tgc ctg cca ggg act 987 Ala Glu Gly Glu Pro Cys Asp His His Gln Asp Cys Leu Pro Gly Thr 270 275 280 tgc tgc gac ctg cgg gag cat ctc tgc aca ccc cac aac cga ggc ctc 1035 Cys Cys Asp Leu Arg Glu His Leu Cys Thr Pro His Asn Arg Gly Leu 285 290 295 300 aac aac aaa tgc ttc gat gac tgc atg tgt gtg gaa ggg ctg cgc tgc 1083 Asn Asn Lys Cys Phe Asp Asp Cys Met Cys Val Glu Gly Leu Arg Cys 305 310 315 tat gcc aaa ttc cac cgg aac cgc agg gtt aca cgg agg aaa ggg cgc 1131 Tyr Ala Lys Phe His Arg Asn Arg Arg Val Thr Arg Arg Lys Gly Arg 320 325 330 tgt gtg gag ccc gag acg gcc aac ggc gac cag gga tcc ttc atc aac 1179 Cys Val Glu Pro Glu Thr Ala Asn Gly Asp Gln Gly Ser Phe Ile Asn 335 340 345 gtc tagcggcccc gcgggactgg ggactgagcc caggaggttt gcacaagccg 1232 Val ggcgatttgt ttgtaactag cagtgggaga tcaagttggg gaacagatgg ctgaggctgc 1292 agactcaggc ccaggacact caaccccagg aggggagccg ctcggcgaat gagctgggtg 1352 ggtgcccagg agccggcccg cagcacctgc acacacgaag tccggaccca cgcagcctcc 1412 atcccgcgtg tcttgctctc cgcgatggca atgccgagag tgccctctac tgtccgactc 1472 cagcactgca acagcttcaa gttcaaaacc aagaggcgtt tttgagagtg gaaaagaaat 1532 ttaaacttcc cgaaagaagg tccaccatca ggagatgaat atggaacatc tcctatgtac 1592 caggcactgt gctaagtgct ggaatacatt atctcattga attatcacaa cgaccttttc 1652 aagtaggcat ttcaccatgc gacaggttga ggaccgtgag gcacgctgga gttatttgac 1712 tcgacttgcc cagggtccca ggtcagtgct tctcaaactc ctgacctcag gtgatccccc 1772 cgtctcagcc tcccaaagtg ctgggattac aggcatgagc cagcatgcct ggcctgtgaa 1832 cgcagaattc ttataaggtg tttagaacag tgcctagcac ctaataaacc tccagtgtta 1892 gctaatttgt tattctagga gaattttaga tgtcggttct ttgacaatga cccatcacat 1952 actctgagat catttctaag tcaccattca agctccttcc ccgaagtgtg ttccatagaa 2012 cactgggacc atgagatgct ctattagaaa gggtcagggt acggttccat ggtcagagag 2072 gtttggaaaa ctgttccggc ctcagccctt ggcagcatgt gcagattcca ggcaccgagg 2132 cagggctgga ggagtaagtg gctttgcaat aaaatgggtg ctggagtcta aaatgatacc 2192 ctgggtggag tgggggagct gagcaggagg ccaggtggca accagtagct gctgggcccg 2252 tggcctgaac cctcctgcac tcctccagct ggagtctcac cgcggatccc aggaatacct 2312 gctgttccca cagggctgcc tttccgtagt ttgtctggag acaccaagag tggtttccat 2372 gcctgctggg aataggctga gcatgcaatg acatgagggc caaggcttgt gggaaaatga 2432 cagcttcaca gccccttgag gagtgaccaa gccacaaagt aaatcctaaa gccacaaccc 2492 cttctaccac tgagctgctg gaggtgggtc cttatttcaa gccatattca acccacccaa 2552 caaaacctaa cattgaggtg gtgggcacac ggcccctgcc gtggggctca ctctgcagct 2612 ggagagacag catacctgaa acctgcaagg aaccggttta taaaacaaca gaacagccag 2672 gaaaatggtg ctaggagaga cagtggagag gccagagaag caaaccactg tggctcctca 2732 ctgggggttt cacggggttg gactgagccc tgtcacctct gtgatagtct tcactctgac 2792 aggcaatggt gactgtgtgt gtttcctggg gaggaggtta gcagggacgg ttgcctttcc 2852 tgggaagggc ggtttgcaga accaggggtt tatattgcag ggagtgtatt ttctgaattc 2912 taagtcagaa caagcagtct gatacaggat ccatggctgg gtcacttctg ggtgcaagag 2972 gctttctaga ccttagacac tcaagattac ggtcccgggc cagtaacagc acctgggagc 3032 ttggtagaaa tgcagaatct tagcctaggc aacataggga gacctcatct ctgcaaaaaa 3092 taacaaaatt agccgggcat ggtggtgcac acctgtagtc ccagctattc tccaggctga 3152 ggtgggagga tcgcttgagc ccaagaggtt gaggctgcag tgagccatga tcgcaccact 3212 gcactccagc ttaggcaata cagcgagacc ttgtctcaaa aaaagacaaa aaaaacaaaa 3272 agaaatgcag attcttgggc cccaccaccc cacgcctact gagccagaat ctctgggggt 3332 ggggcccagc catttggctt ttcacaagtt ctccaggtca ttcttgggca cgatcaaatt 3392 tgagaatcac aggtctagga tacgacgggg aaaacagaaa tgtggggtgg tcagggacat 3452 tcggataatt cgggctattt gtattcaggt gtgagctggc aaatccgaga cctgttttgc 3512 gtagctaatt accagcaatg acaaactccc aggctctgag gcccaagcct cctgggctgc 3572 aactggtctt tatttttgga ggcaatgaat ggagcacctc ggcctgggac cctcagtgta 3632 gggttttctg actcttaggc aacttcctag ggtgctgtac ttccttttta aagttgggga 3692 gcggcagggg gagggggaag tgccacgccc ttgtagtttc atgatgtcat gttgcatgtg 3752 ctcttgagct gtaaataaag agacgatggt taaaaagcc 3791 <210> 296 <211> 349 <212> PRT <213> Homo sapiens <400> 296 Met Ala Gly Pro Ala Ile His Thr Ala Pro Met Leu Phe Leu Val Leu 1 5 10 15 Leu Leu Pro Leu Glu Leu Ser Leu Ala Gly Ala Leu Ala Pro Gly Thr 20 25 30 Pro Ala Arg Asn Phe Pro Glu Asn His Ile Asp Leu Pro Gly Pro Ala 35 40 45 Leu Trp Thr Pro Gln Ala Ser His His Arg Arg Arg Gly Pro Gly Lys 50 55 60 Lys Glu Trp Gly Pro Gly Leu Pro Ser Gln Ala Gln Asp Gly Ala Val 65 70 75 80 Val Thr Ala Thr Arg Gln Ala Ser Arg Leu Pro Glu Ala Glu Gly Leu 85 90 95 Leu Pro Glu Gln Ser Pro Ala Gly Leu Leu Gln Asp Lys Asp Leu Leu 100 105 110 Leu Gly Leu Ala Leu Pro Tyr Pro Glu Lys Glu Asn Arg Pro Pro Gly 115 120 125 Trp Glu Arg Thr Arg Lys Arg Ser Arg Glu His Lys Arg Arg Arg Asp 130 135 140 Arg Leu Arg Leu His Gln Gly Arg Ala Leu Val Arg Gly Pro Ser Ser 145 150 155 160 Leu Met Lys Lys Ala Glu Leu Ser Glu Ala Gln Val Leu Asp Ala Ala 165 170 175 Met Glu Glu Ser Ser Thr Ser Leu Ala Pro Thr Met Phe Phe Leu Thr 180 185 190 Thr Phe Glu Ala Ala Pro Ala Thr Glu Glu Ser Leu Ile Leu Pro Val 195 200 205 Thr Ser Leu Arg Pro Gln Gln Ala Gln Pro Arg Ser Asp Gly Glu Val 210 215 220 Met Pro Thr Leu Asp Met Ala Leu Phe Asp Trp Thr Asp Tyr Glu Asp 225 230 235 240 Leu Lys Pro Asp Gly Trp Pro Ser Ala Lys Lys Lys Glu Lys His Arg 245 250 255 Gly Lys Leu Ser Ser Asp Gly Asn Glu Thr Ser Pro Ala Glu Gly Glu 260 265 270 Pro Cys Asp His His Gln Asp Cys Leu Pro Gly Thr Cys Cys Asp Leu 275 280 285 Arg Glu His Leu Cys Thr Pro His Asn Arg Gly Leu Asn Asn Lys Cys 290 295 300 Phe Asp Asp Cys Met Cys Val Glu Gly Leu Arg Cys Tyr Ala Lys Phe 305 310 315 320 His Arg Asn Arg Arg Val Thr Arg Arg Lys Gly Arg Cys Val Glu Pro 325 330 335 Glu Thr Ala Asn Gly Asp Gln Gly Ser Phe Ile Asn Val 340 345 <210> 297 <211> 2583 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (264)..(989) <400> 297 ctgctctggg gcggcattgc cagccggctg taggcattca gggcagtgtc ttctgcatct 60 cctaggaacc tcgggagcgg cagctccggc gcctggtagc gagaggcggg ttccggagat 120 cccggcctca cttcgtccca ctgtggttag gggtgagtcc tgcaaatgtt aagtgatttg 180 ctcaaggtgc ccatttcgca ggaattggag cccaggccag ttctctgagc ctatcattag 240 ggctaaagga gtgcgtgatc aga atg gtg tct gga cgg ttc tac ttg tcc tgc 293 Met Val Ser Gly Arg Phe Tyr Leu Ser Cys 1 5 10 ctg ctg ctg ggg tcc ctg ggc tct atg tgc atc ctc ttc act atc tac 341 Leu Leu Leu Gly Ser Leu Gly Ser Met Cys Ile Leu Phe Thr Ile Tyr 15 20 25 tgg atg cag tac tgg cgt ggt ggc ttt gcc tgg aat ggc agc atc tac 389 Trp Met Gln Tyr Trp Arg Gly Gly Phe Ala Trp Asn Gly Ser Ile Tyr 30 35 40 atg ttc aac tgg cac cca gtg ctt atg gtt gct ggc atg gtg gta ttc 437 Met Phe Asn Trp His Pro Val Leu Met Val Ala Gly Met Val Val Phe 45 50 55 tat gga ggt gcg tca ctg gtg tac cgc ctg ccc cag tcg tgg gtg ggg 485 Tyr Gly Gly Ala Ser Leu Val Tyr Arg Leu Pro Gln Ser Trp Val Gly 60 65 70 ccc aaa ctg ccc tgg aaa ctc ctc cat gca gcg ctg cac ctg atg gcc 533 Pro Lys Leu Pro Trp Lys Leu Leu His Ala Ala Leu His Leu Met Ala 75 80 85 90 ttc gtc ctc act gtt gtg ggg ctg gtt gct gtc ttt acg ttt cac aac 581 Phe Val Leu Thr Val Val Gly Leu Val Ala Val Phe Thr Phe His Asn 95 100 105 cat gga agg act gcc aac ctc tac tcc ctt cac agc tgg ctg ggc atc 629 His Gly Arg Thr Ala Asn Leu Tyr Ser Leu His Ser Trp Leu Gly Ile 110 115 120 acc act gtc ttc ctc ttc gcc tgc cag tgg ttc ctg ggc ttt gct gtc 677 Thr Thr Val Phe Leu Phe Ala Cys Gln Trp Phe Leu Gly Phe Ala Val 125 130 135 ttc ctc ctg ccc tgg gcg tcc atg tgg ctg cgc agc ctc cta aaa cct 725 Phe Leu Leu Pro Trp Ala Ser Met Trp Leu Arg Ser Leu Leu Lys Pro 140 145 150 atc cac gtc ttt ttt gga gcc gcc atc ctc tct ctg tcc atc gca tcc 773 Ile His Val Phe Phe Gly Ala Ala Ile Leu Ser Leu Ser Ile Ala Ser 155 160 165 170 gtc att tcg ggc att aat gag aag ctt ttc ttc agt ttg aaa aac acc 821 Val Ile Ser Gly Ile Asn Glu Lys Leu Phe Phe Ser Leu Lys Asn Thr 175 180 185 acc agg cca tac cac agc ctg ccc agt gag gcg gtc ttt gcc aac agc 869 Thr Arg Pro Tyr His Ser Leu Pro Ser Glu Ala Val Phe Ala Asn Ser 190 195 200 acc ggg atg ctg gtg gtg gcc ttt ggg ctg ctg gtg ctc tac atc ctt 917 Thr Gly Met Leu Val Val Ala Phe Gly Leu Leu Val Leu Tyr Ile Leu 205 210 215 ctg gct tca tct tgg aag cgc cca gag ccg ggg atc ctg acc gac aga 965 Leu Ala Ser Ser Trp Lys Arg Pro Glu Pro Gly Ile Leu Thr Asp Arg 220 225 230 cag ccc ctg ctg cat gat ggg gag tgaagcagca ggaaggggct cccaagagct 1019 Gln Pro Leu Leu His Asp Gly Glu 235 240 cctggtggtg cagcctgtgc tcccctcaga agctctgctc ttcccagggc tcccggctgg 1079 tttcagcagg cgactttctt ccaatgctgg gcccagactt cttgcctggg tgctggcctg 1139 ccctctccgg ccgcttgctg cctgtctgct ttccttggtg gctttgcctg ggtgctgggc 1199 ctgccctctc cggccgcttg ctgcctgtct gctttccttg gtggctttgc ctgggtgctg 1259 ggcctgcctt ctctggctgc ttgctgcctg tctgctttcc ttggtggctt tggcttctgc 1319 actccttggc gtcagcctct caggtcctcc attcacacga ggtcctcctc gctctggccg 1379 ctcttgctgc tcctgtctga agaaatcaga ctgatttcct cttaagactc ctagggatgt 1439 ggtgaagagc tgggactcaa gtgcagtcca cggtgtgaaa catgagggag gtgaggtgtc 1499 cgtccacttc ccccataaag gtgtgcattt cagttaggct gccccgccac agagcaggct 1559 tcatctgctc tgccatccag ccccatctgg atgtgaggtg gggtggagac atcatggggt 1619 gattgcagaa agggggagtg gcggcccacg cagcttctgc tgaggagctg accgctctga 1679 gctgttctgt ttcgtattgc tgctctgtgt ctgcatgtat tgtgaccgtg cggctccacc 1739 tcttccagct gctgctacag ctgaggcctg gatcccggcc tttccctgtg acttacgtgt 1799 ctgtcaccgg caggcagccc tacaaatcct ggtgacctgc tctcccaaga acagagcctg 1859 tccccagatg tcccagtagc gatgagtaac agaggtggct gtggacttcc tctacttctc 1919 cttgctggat cagggccttc ctgcctcccg ctgggcaggt ctggccttgc tctcttggca 1979 gggccccagc ccctctgacc actctgcagc tcaccatgca gctgatgcca aagttgtggt 2039 gtccagtgtg cagcagccct gggagccact gccaccttca gaggggttcc ttgctgagac 2099 ccacattgct tcacctggcc ccaccatggc tgcttgcctg gcccaaccta gcgttctgtg 2159 ccatgctaga gcttgagctg ttgctcttct tcaggggagg aaatagggtg gagagcggga 2219 agggtcttgc tcctaagtgt tgctgctgtg gcttttttgc cttctccaaa gacgcactgc 2279 caggtcccaa gcttcagact gctgtgctta gtaagcaagt gagaagcctg gggtttggag 2339 cccacctact ctctggcagc atcagcatcc tactcctggc aacatcaggc caacgtccac 2399 cccagcctca cattgccaga tgttggcaga agggctaata ttgaccgtct tgactggctg 2459 gagccttcaa agccactggg atgtcctcca ggcacctggg tcccatgacc agctccccgt 2519 ctccataggg gtaggcattt cactggttta tgaagctcga gtttcattaa atatgttaag 2579 aatc 2583 <210> 298 <211> 242 <212> PRT <213> Homo sapiens <400> 298 Met Val Ser Gly Arg Phe Tyr Leu Ser Cys Leu Leu Leu Gly Ser Leu 1 5 10 15 Gly Ser Met Cys Ile Leu Phe Thr Ile Tyr Trp Met Gln Tyr Trp Arg 20 25 30 Gly Gly Phe Ala Trp Asn Gly Ser Ile Tyr Met Phe Asn Trp His Pro 35 40 45 Val Leu Met Val Ala Gly Met Val Val Phe Tyr Gly Gly Ala Ser Leu 50 55 60 Val Tyr Arg Leu Pro Gln Ser Trp Val Gly Pro Lys Leu Pro Trp Lys 65 70 75 80 Leu Leu His Ala Ala Leu His Leu Met Ala Phe Val Leu Thr Val Val 85 90 95 Gly Leu Val Ala Val Phe Thr Phe His Asn His Gly Arg Thr Ala Asn 100 105 110 Leu Tyr Ser Leu His Ser Trp Leu Gly Ile Thr Thr Val Phe Leu Phe 115 120 125 Ala Cys Gln Trp Phe Leu Gly Phe Ala Val Phe Leu Leu Pro Trp Ala 130 135 140 Ser Met Trp Leu Arg Ser Leu Leu Lys Pro Ile His Val Phe Phe Gly 145 150 155 160 Ala Ala Ile Leu Ser Leu Ser Ile Ala Ser Val Ile Ser Gly Ile Asn 165 170 175 Glu Lys Leu Phe Phe Ser Leu Lys Asn Thr Thr Arg Pro Tyr His Ser 180 185 190 Leu Pro Ser Glu Ala Val Phe Ala Asn Ser Thr Gly Met Leu Val Val 195 200 205 Ala Phe Gly Leu Leu Val Leu Tyr Ile Leu Leu Ala Ser Ser Trp Lys 210 215 220 Arg Pro Glu Pro Gly Ile Leu Thr Asp Arg Gln Pro Leu Leu His Asp 225 230 235 240 Gly Glu <210> 299 <211> 2492 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (30)..(1517) <400> 299 gttcgcgcag gtgcggcgcc tgggtcccc atg gcg ctg tgg cgc ggc tcc gcg 53 Met Ala Leu Trp Arg Gly Ser Ala 1 5 tac gcg ggc ttc ctg gcg ctg gcc gtg ggc tgc gtc ttc ctg ctg gag 101 Tyr Ala Gly Phe Leu Ala Leu Ala Val Gly Cys Val Phe Leu Leu Glu 10 15 20 cca gag ctg cca ggc tcg gcg ctg cgc tct ctc tgg agc tcg ctg tgt 149 Pro Glu Leu Pro Gly Ser Ala Leu Arg Ser Leu Trp Ser Ser Leu Cys 25 30 35 40 ctg ggg ccc gcg cct gcg ccc ccg gga ccc gtc tcc ccc gag ggc cgg 197 Leu Gly Pro Ala Pro Ala Pro Pro Gly Pro Val Ser Pro Glu Gly Arg 45 50 55 ttg gcg gca gcc tgg gac gcg ctt atc gtg cgg cca gtc cgg cgc tgg 245 Leu Ala Ala Ala Trp Asp Ala Leu Ile Val Arg Pro Val Arg Arg Trp 60 65 70 cgc cgc gtg gca gtg gga gtc aat gca tgt gtt gat gtg gtg ctc tca 293 Arg Arg Val Ala Val Gly Val Asn Ala Cys Val Asp Val Val Leu Ser 75 80 85 ggg gtg aag ctc ttg cag gca ctt ggc ctt agt cct ggg aat ggg aaa 341 Gly Val Lys Leu Leu Gln Ala Leu Gly Leu Ser Pro Gly Asn Gly Lys 90 95 100 gat cac agc att ctg cat tca agg aat gat ctg gaa gaa gcc ttc att 389 Asp His Ser Ile Leu His Ser Arg Asn Asp Leu Glu Glu Ala Phe Ile 105 110 115 120 cac ttc atg ggg aag gga gca gct gct gag cgc ttc ttc agt gat aag 437 His Phe Met Gly Lys Gly Ala Ala Ala Glu Arg Phe Phe Ser Asp Lys 125 130 135 gaa act ttt cac gac att gcc cag gtt gcg tca gag ttc cca gga gcc 485 Glu Thr Phe His Asp Ile Ala Gln Val Ala Ser Glu Phe Pro Gly Ala 140 145 150 cag cac tat gta gga gga aat gca gct tta att gga cag aaa ttt gca 533 Gln His Tyr Val Gly Gly Asn Ala Ala Leu Ile Gly Gln Lys Phe Ala 155 160 165 gcc aac tca gat tta aag gtt ctt ctt tgc ggt cca gtt ggt cca aag 581 Ala Asn Ser Asp Leu Lys Val Leu Leu Cys Gly Pro Val Gly Pro Lys 170 175 180 cta cat gag ctt ctt gat gac aat gtc ttt gtt cca cca gag tca ttg 629 Leu His Glu Leu Leu Asp Asp Asn Val Phe Val Pro Pro Glu Ser Leu 185 190 195 200 cag gaa gtg gat gag ttc cac ctc att tta gag tat caa gca ggg gag 677 Gln Glu Val Asp Glu Phe His Leu Ile Leu Glu Tyr Gln Ala Gly Glu 205 210 215 gag tgg ggc cag tta aaa gct ccc cat gcc aac cga ttc atc ttc tct 725 Glu Trp Gly Gln Leu Lys Ala Pro His Ala Asn Arg Phe Ile Phe Ser 220 225 230 cac gac ctc tcc aac ggg gcc atg aat atg ctg gag gtg ttt gtg tct 773 His Asp Leu Ser Asn Gly Ala Met Asn Met Leu Glu Val Phe Val Ser 235 240 245 agc ctg gag gag ttt cag cca gac ctg gtg gtc ctc tct gga ttg cac 821 Ser Leu Glu Glu Phe Gln Pro Asp Leu Val Val Leu Ser Gly Leu His 250 255 260 atg atg gag gga caa agc aag gag ctc cag agg aag aga ctc ttg gag 869 Met Met Glu Gly Gln Ser Lys Glu Leu Gln Arg Lys Arg Leu Leu Glu 265 270 275 280 gtt gta acc tcc att tct gac atc ccc act ggt att cca gtt cac cta 917 Val Val Thr Ser Ile Ser Asp Ile Pro Thr Gly Ile Pro Val His Leu 285 290 295 gag ctg gcc agt atg act aac agg gag ctc atg agc agc att gtc cat 965 Glu Leu Ala Ser Met Thr Asn Arg Glu Leu Met Ser Ser Ile Val His 300 305 310 cag gtc ttt ccc gcg gtg act tcc ctt ggg ctg aat gaa cag gag ctg 1013 Gln Val Phe Pro Ala Val Thr Ser Leu Gly Leu Asn Glu Gln Glu Leu 315 320 325 tta ttt ctc acc cag tca gcc tct gga cct cac tct tct ctc tct tcc 1061 Leu Phe Leu Thr Gln Ser Ala Ser Gly Pro His Ser Ser Leu Ser Ser 330 335 340 tgg aac ggt gtt cct gat gtg ggc atg gtc agt gac atc ctc ttc tgg 1109 Trp Asn Gly Val Pro Asp Val Gly Met Val Ser Asp Ile Leu Phe Trp 345 350 355 360 atc ttg aaa gaa cat ggg agg agt aaa agc aga gcc tcg gat ctc acc 1157 Ile Leu Lys Glu His Gly Arg Ser Lys Ser Arg Ala Ser Asp Leu Thr 365 370 375 agg atc cat ttc cac acg ctg gtc tac cac atc ctg gca act gtg gat 1205 Arg Ile His Phe His Thr Leu Val Tyr His Ile Leu Ala Thr Val Asp 380 385 390 gga cac tgg gcc aac cag ctg gca gcc gtg gct gca gga gct cgt gtg 1253 Gly His Trp Ala Asn Gln Leu Ala Ala Val Ala Ala Gly Ala Arg Val 395 400 405 gct ggg aca cag gcc tgc gcc aca gaa acc ata gac acc agc cga gtg 1301 Ala Gly Thr Gln Ala Cys Ala Thr Glu Thr Ile Asp Thr Ser Arg Val 410 415 420 tct ctg agg gca ccc caa gag ttc atg act tcc cat tcg gag gca ggc 1349 Ser Leu Arg Ala Pro Gln Glu Phe Met Thr Ser His Ser Glu Ala Gly 425 430 435 440 tcc agg att gta tta aac cca aac aag cca gta gta gaa tgg cac aga 1397 Ser Arg Ile Val Leu Asn Pro Asn Lys Pro Val Val Glu Trp His Arg 445 450 455 gag gga ata tcc ttc cac ttc aca cca gta ttg gtg tgt aaa gac ccc 1445 Glu Gly Ile Ser Phe His Phe Thr Pro Val Leu Val Cys Lys Asp Pro 460 465 470 att cga act gta ggc ctt gga gat gcc att tca gcc gaa gga ctc ttc 1493 Ile Arg Thr Val Gly Leu Gly Asp Ala Ile Ser Ala Glu Gly Leu Phe 475 480 485 tat tcg gaa gta cac cct cac tat taggaagatt cttaggggta atttttctga 1547 Tyr Ser Glu Val His Pro His Tyr 490 495 ggaaggagaa ctagccaact taagaattac aggaagaaag tggtttggaa gacagccaaa 1607 gaaataaaag cagattaaac tgtatcaggt acattccagc ctgttggcaa ctccataaaa 1667 acatttcaga ttttaatccg aatttagcta atgagactgg atttttgttt tttatgttgt 1727 gtgtcacaga gctaaaaact cagttcccaa atccccagtt tatgcagcgc catcaggtat 1787 tttaagctaa acttcttcac ccctgagagc atgtcagctg gagaaaagca gttcttcctt 1847 gcccacttga gaagtgcacg cccactcacc caacatcctg gtctctagga aagcctcatg 1907 tgaggttcct ctttctttca gctcagtgcc catgggcaag gatcatgatt tccattccgt 1967 gttacaatga caatatttaa tgagcataac cttctcagtc tcctgctctc aaatttagga 2027 cagagccgct aaggacaaaa caatccctcc cgtgctttat gatggcagca ggggctgggg 2087 agcctctgag ggactctttc attctgcagt tgtctggaag cctgggtggc gtcatgagct 2147 gaaggatcat gctttcctgt cctggctcca taggttatag gctggctggt gaaaggttca 2207 cgtggcccag gctgaacttc attgcctagc tttggatgtg ctttctgcca taaagactga 2267 tttttgttcg ttctgagcct tcaaggaatt tgttttttac aactggaata tgctcctgtg 2327 tgtgttaaca gatcatggat gttttatgtt ttcactgatc atttaaagag tttgacctca 2387 gagctccagg atcatcagta aatttgtcat gttatatatt tattttttta taaatcaaga 2447 cttctgtgtg ctcttaaata tattaaaaac aatttacatt tcagg 2492 <210> 300 <211> 496 <212> PRT <213> Homo sapiens <400> 300 Met Ala Leu Trp Arg Gly Ser Ala Tyr Ala Gly Phe Leu Ala Leu Ala 1 5 10 15 Val Gly Cys Val Phe Leu Leu Glu Pro Glu Leu Pro Gly Ser Ala Leu 20 25 30 Arg Ser Leu Trp Ser Ser Leu Cys Leu Gly Pro Ala Pro Ala Pro Pro 35 40 45 Gly Pro Val Ser Pro Glu Gly Arg Leu Ala Ala Ala Trp Asp Ala Leu 50 55 60 Ile Val Arg Pro Val Arg Arg Trp Arg Arg Val Ala Val Gly Val Asn 65 70 75 80 Ala Cys Val Asp Val Val Leu Ser Gly Val Lys Leu Leu Gln Ala Leu 85 90 95 Gly Leu Ser Pro Gly Asn Gly Lys Asp His Ser Ile Leu His Ser Arg 100 105 110 Asn Asp Leu Glu Glu Ala Phe Ile His Phe Met Gly Lys Gly Ala Ala 115 120 125 Ala Glu Arg Phe Phe Ser Asp Lys Glu Thr Phe His Asp Ile Ala Gln 130 135 140 Val Ala Ser Glu Phe Pro Gly Ala Gln His Tyr Val Gly Gly Asn Ala 145 150 155 160 Ala Leu Ile Gly Gln Lys Phe Ala Ala Asn Ser Asp Leu Lys Val Leu 165 170 175 Leu Cys Gly Pro Val Gly Pro Lys Leu His Glu Leu Leu Asp Asp Asn 180 185 190 Val Phe Val Pro Pro Glu Ser Leu Gln Glu Val Asp Glu Phe His Leu 195 200 205 Ile Leu Glu Tyr Gln Ala Gly Glu Glu Trp Gly Gln Leu Lys Ala Pro 210 215 220 His Ala Asn Arg Phe Ile Phe Ser His Asp Leu Ser Asn Gly Ala Met 225 230 235 240 Asn Met Leu Glu Val Phe Val Ser Ser Leu Glu Glu Phe Gln Pro Asp 245 250 255 Leu Val Val Leu Ser Gly Leu His Met Met Glu Gly Gln Ser Lys Glu 260 265 270 Leu Gln Arg Lys Arg Leu Leu Glu Val Val Thr Ser Ile Ser Asp Ile 275 280 285 Pro Thr Gly Ile Pro Val His Leu Glu Leu Ala Ser Met Thr Asn Arg 290 295 300 Glu Leu Met Ser Ser Ile Val His Gln Val Phe Pro Ala Val Thr Ser 305 310 315 320 Leu Gly Leu Asn Glu Gln Glu Leu Leu Phe Leu Thr Gln Ser Ala Ser 325 330 335 Gly Pro His Ser Ser Leu Ser Ser Trp Asn Gly Val Pro Asp Val Gly 340 345 350 Met Val Ser Asp Ile Leu Phe Trp Ile Leu Lys Glu His Gly Arg Ser 355 360 365 Lys Ser Arg Ala Ser Asp Leu Thr Arg Ile His Phe His Thr Leu Val 370 375 380 Tyr His Ile Leu Ala Thr Val Asp Gly His Trp Ala Asn Gln Leu Ala 385 390 395 400 Ala Val Ala Ala Gly Ala Arg Val Ala Gly Thr Gln Ala Cys Ala Thr 405 410 415 Glu Thr Ile Asp Thr Ser Arg Val Ser Leu Arg Ala Pro Gln Glu Phe 420 425 430 Met Thr Ser His Ser Glu Ala Gly Ser Arg Ile Val Leu Asn Pro Asn 435 440 445 Lys Pro Val Val Glu Trp His Arg Glu Gly Ile Ser Phe His Phe Thr 450 455 460 Pro Val Leu Val Cys Lys Asp Pro Ile Arg Thr Val Gly Leu Gly Asp 465 470 475 480 Ala Ile Ser Ala Glu Gly Leu Phe Tyr Ser Glu Val His Pro His Tyr 485 490 495 <210> 301 <211> 3080 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (22)..(2439) <400> 301 gcacatgcgc cttgagggaa g atg gca cct gcc ggc tgc tgc tgc tgc tgc 51 Met Ala Pro Ala Gly Cys Cys Cys Cys Cys 1 5 10 tgc ttc tgg ggc ggc gct gtg gcc gcc gcg ggc gcc gcc cgg cgt gtc 99 Cys Phe Trp Gly Gly Ala Val Ala Ala Ala Gly Ala Ala Arg Arg Val 15 20 25 ctg ctg ctg ctg ctg ctg ggg gtc ctg tcc gcc cgg ctg cgg cca ggc 147 Leu Leu Leu Leu Leu Leu Gly Val Leu Ser Ala Arg Leu Arg Pro Gly 30 35 40 gcc ctg gcc acc gag cac tac tcg ccg ctc tcc ctg ctc aag cag gag 195 Ala Leu Ala Thr Glu His Tyr Ser Pro Leu Ser Leu Leu Lys Gln Glu 45 50 55 ctg cag cac cgg cag cag cag gag gcc ccg gcg ggc ggc ggc ggc tgc 243 Leu Gln His Arg Gln Gln Gln Glu Ala Pro Ala Gly Gly Gly Gly Cys 60 65 70 agc ccg cag tcc ggg gac tgg ggg gac cag tac tct gcc gag tgc ggc 291 Ser Pro Gln Ser Gly Asp Trp Gly Asp Gln Tyr Ser Ala Glu Cys Gly 75 80 85 90 gag tca tcc ttt ttg aac ttc cat gac tca gac tgc gaa ccc aag gga 339 Glu Ser Ser Phe Leu Asn Phe His Asp Ser Asp Cys Glu Pro Lys Gly 95 100 105 tca tca ccc tgt gac tcc ttg ctt tcc ctc aac act gag aag att ctg 387 Ser Ser Pro Cys Asp Ser Leu Leu Ser Leu Asn Thr Glu Lys Ile Leu 110 115 120 agc cag gcc aag tct att gca gaa cag aag aga ttc ccg ttt gcc act 435 Ser Gln Ala Lys Ser Ile Ala Glu Gln Lys Arg Phe Pro Phe Ala Thr 125 130 135 gat aat gac agc aca aat gaa gag tta gct att gct tat gtc ttg att 483 Asp Asn Asp Ser Thr Asn Glu Glu Leu Ala Ile Ala Tyr Val Leu Ile 140 145 150 ggc agt ggt ctg tat gat gaa gca ata cgg cat ttt tca aca atg ctt 531 Gly Ser Gly Leu Tyr Asp Glu Ala Ile Arg His Phe Ser Thr Met Leu 155 160 165 170 cag att ctg tcc cct ctg gga cga att aat gaa gca gtg aat gac ctc 579 Gln Ile Leu Ser Pro Leu Gly Arg Ile Asn Glu Ala Val Asn Asp Leu 175 180 185 act aaa gct atc caa ctg cag ccc tca gca cgg ctg tac aga cat cgg 627 Thr Lys Ala Ile Gln Leu Gln Pro Ser Ala Arg Leu Tyr Arg His Arg 190 195 200 gga acc ctg tac ttc ata tca gag gac tat gca aca gcc cat gaa gac 675 Gly Thr Leu Tyr Phe Ile Ser Glu Asp Tyr Ala Thr Ala His Glu Asp 205 210 215 ttt cag cag tcc tta gaa ctg aac aaa aac cag cct ata gct atg cta 723 Phe Gln Gln Ser Leu Glu Leu Asn Lys Asn Gln Pro Ile Ala Met Leu 220 225 230 tac aaa ggt tta act ttc ttt cac aga gga ctt ctg aag gaa gct att 771 Tyr Lys Gly Leu Thr Phe Phe His Arg Gly Leu Leu Lys Glu Ala Ile 235 240 245 250 gaa tcc ttc aaa gaa gct ttg aag cag aaa gtt gac ttt att gat gca 819 Glu Ser Phe Lys Glu Ala Leu Lys Gln Lys Val Asp Phe Ile Asp Ala 255 260 265 tat aaa agt cta ggg cag gca tat aga gaa ctg ggc aat ttt gaa gca 867 Tyr Lys Ser Leu Gly Gln Ala Tyr Arg Glu Leu Gly Asn Phe Glu Ala 270 275 280 gcc act gag agc ttt caa aag gca ctg ttg ctc aac caa aat cat gtg 915 Ala Thr Glu Ser Phe Gln Lys Ala Leu Leu Leu Asn Gln Asn His Val 285 290 295 caa acc ctc cag ctc cgg gga atg atg ctc tac cac cac ggc agc tta 963 Gln Thr Leu Gln Leu Arg Gly Met Met Leu Tyr His His Gly Ser Leu 300 305 310 cag gaa gcc ctt aag aac ttt aag cgg tgt ctg cag cta gag cca tat 1011 Gln Glu Ala Leu Lys Asn Phe Lys Arg Cys Leu Gln Leu Glu Pro Tyr 315 320 325 330 aat gaa gtg tgc cag tat atg aaa ggg ctc agc cat gtt gcc atg gga 1059 Asn Glu Val Cys Gln Tyr Met Lys Gly Leu Ser His Val Ala Met Gly 335 340 345 cag ttt tat gaa ggg ata aaa gca caa aca aaa gtt atg ctg aat gat 1107 Gln Phe Tyr Glu Gly Ile Lys Ala Gln Thr Lys Val Met Leu Asn Asp 350 355 360 cct ctc cca ggc cag aag gct agc cct gag tat ctt aaa gta aag tat 1155 Pro Leu Pro Gly Gln Lys Ala Ser Pro Glu Tyr Leu Lys Val Lys Tyr 365 370 375 ctc cga gag tat tct cga tat ctt cat gca cac ctt gat acc ccc ctt 1203 Leu Arg Glu Tyr Ser Arg Tyr Leu His Ala His Leu Asp Thr Pro Leu 380 385 390 acg gaa tat aac att gat gtg gat ctg cct gga agc ttt aag gac cac 1251 Thr Glu Tyr Asn Ile Asp Val Asp Leu Pro Gly Ser Phe Lys Asp His 395 400 405 410 tgg gct aaa aat ttg cct ttc ctc ata gaa gac tac gaa gag cag cca 1299 Trp Ala Lys Asn Leu Pro Phe Leu Ile Glu Asp Tyr Glu Glu Gln Pro 415 420 425 ggg ttg caa ccc cac ata aaa gat gtg tta cat cag aat ttt gag agt 1347 Gly Leu Gln Pro His Ile Lys Asp Val Leu His Gln Asn Phe Glu Ser 430 435 440 tat aag cct gaa gta cag gag ctg att tgt gtg gct gat cgt ttg gga 1395 Tyr Lys Pro Glu Val Gln Glu Leu Ile Cys Val Ala Asp Arg Leu Gly 445 450 455 tcc ctg atg caa tat gaa aca cct ggt ttc ctg cca aac aag aga ata 1443 Ser Leu Met Gln Tyr Glu Thr Pro Gly Phe Leu Pro Asn Lys Arg Ile 460 465 470 cac aga gct atg ggt ttg gcc gca ttg gag gtc atg caa gcc gtg cag 1491 His Arg Ala Met Gly Leu Ala Ala Leu Glu Val Met Gln Ala Val Gln 475 480 485 490 cgt aca tgg acc aac tcg aaa gtt cga atg aat ggg aag aca cgg ttg 1539 Arg Thr Trp Thr Asn Ser Lys Val Arg Met Asn Gly Lys Thr Arg Leu 495 500 505 atg cag tgg aga gac atg ttt gac att gca gtt aaa tgg aga agg att 1587 Met Gln Trp Arg Asp Met Phe Asp Ile Ala Val Lys Trp Arg Arg Ile 510 515 520 gct gac cca gac cag ccc gtg ctg tgg tta gat caa atg cca gca cga 1635 Ala Asp Pro Asp Gln Pro Val Leu Trp Leu Asp Gln Met Pro Ala Arg 525 530 535 agt ctt agc aga ggt ttt aac aac cac att aat tta atc agg gga cag 1683 Ser Leu Ser Arg Gly Phe Asn Asn His Ile Asn Leu Ile Arg Gly Gln 540 545 550 gtg atc aac atg aga tac cta gaa tat ttt gag aaa ata ctt cat ttt 1731 Val Ile Asn Met Arg Tyr Leu Glu Tyr Phe Glu Lys Ile Leu His Phe 555 560 565 570 att aaa gac aga att ctt gtt tat cat gga gct aat aat cct aaa gga 1779 Ile Lys Asp Arg Ile Leu Val Tyr His Gly Ala Asn Asn Pro Lys Gly 575 580 585 ttg ctg gaa gtt cgg gaa gcc ctg gaa aag gta cac aaa gta gaa gac 1827 Leu Leu Glu Val Arg Glu Ala Leu Glu Lys Val His Lys Val Glu Asp 590 595 600 ctt ctt ccg att atg aag ttt aat act aaa acg aag gat ggg ttc acc 1875 Leu Leu Pro Ile Met Lys Phe Asn Thr Lys Thr Lys Asp Gly Phe Thr 605 610 615 gtg aac aca aaa gtt ccc agc ctt aaa gac caa ggg aag gaa tat gat 1923 Val Asn Thr Lys Val Pro Ser Leu Lys Asp Gln Gly Lys Glu Tyr Asp 620 625 630 gga ttc aca atc acg att aca gga gac aaa gtt ggc aat ata tta ttt 1971 Gly Phe Thr Ile Thr Ile Thr Gly Asp Lys Val Gly Asn Ile Leu Phe 635 640 645 650 tct gtg gaa act caa acc acg gaa gaa agg aca caa tta tat cat gct 2019 Ser Val Glu Thr Gln Thr Thr Glu Glu Arg Thr Gln Leu Tyr His Ala 655 660 665 gaa ata gat gca ctt tat aaa gat ttg aca gca aaa gga aaa gta ttg 2067 Glu Ile Asp Ala Leu Tyr Lys Asp Leu Thr Ala Lys Gly Lys Val Leu 670 675 680 att ctt tca tca gaa ttt ggg gag gct gat gct gtc tgc aac tta atc 2115 Ile Leu Ser Ser Glu Phe Gly Glu Ala Asp Ala Val Cys Asn Leu Ile 685 690 695 tta tcc tta gtt tat tac ttt tat aat tta atg cca ctc tct cga gga 2163 Leu Ser Leu Val Tyr Tyr Phe Tyr Asn Leu Met Pro Leu Ser Arg Gly 700 705 710 tcc agt gta att gct tac tcg gtc atc gtg gga gca ctg atg gca agt 2211 Ser Ser Val Ile Ala Tyr Ser Val Ile Val Gly Ala Leu Met Ala Ser 715 720 725 730 gga aaa gaa gta gca gga aaa att ccc aaa ggg aag tta gtc gac ttt 2259 Gly Lys Glu Val Ala Gly Lys Ile Pro Lys Gly Lys Leu Val Asp Phe 735 740 745 gaa gct atg aca gcc cct ggt tca gag gcc ttt agc aaa gtc gcc aaa 2307 Glu Ala Met Thr Ala Pro Gly Ser Glu Ala Phe Ser Lys Val Ala Lys 750 755 760 agc tgg atg aac ttg aaa agt att tca cct tct tat aag act ctt cca 2355 Ser Trp Met Asn Leu Lys Ser Ile Ser Pro Ser Tyr Lys Thr Leu Pro 765 770 775 tca gta tca gaa acg ttt cca acg tta aga tcg atg att gag gtg cta 2403 Ser Val Ser Glu Thr Phe Pro Thr Leu Arg Ser Met Ile Glu Val Leu 780 785 790 aac aca gac tct tct cca cgt tgt ctt aag aaa ctc tagttctgct 2449 Asn Thr Asp Ser Ser Pro Arg Cys Leu Lys Lys Leu 795 800 805 gctgtattta tacaagtaaa gggccggacc tcttgcttct taagttattt tttaaaacat 2509 ggaattataa agaaattagg tcctctatta cttttgatac caatttttat aggaattgaa 2569 tacttgaaat cattttcttt acttttctga accataatga aaatcatgaa agaggctttc 2629 ggggggaaaa agctacttga cttggaggga aagcgtatgt attagccggc agcctgttgg 2689 ttcccactta taaagtcata taactccttc cttacagtaa aaaaaatttt cctcaacaac 2749 taaaatataa tactgaagat gaacaaaaac aaaaccaaat aggagtgttt gtattccttt 2809 agagatctgg atatttttca aagacttgct ttttacgcac attgtgatag agcatctttt 2869 gttgactcac gtaacctcca tgtgtgggtc ctttgtttta ttagaaccat ggaagaaggt 2929 tcctgggcca tcagtatgtg ttgcagagct cacagccagg aacacttatt ttgaacaatg 2989 cagacagtac ttgccagagt cccaaatgct gaattattga accatgtttt tttttccttt 3049 gttgaaaaaa ataaaccagg gtgatttcta t 3080 <210> 302 <211> 806 <212> PRT <213> Homo sapiens <400> 302 Met Ala Pro Ala Gly Cys Cys Cys Cys Cys Cys Phe Trp Gly Gly Ala 1 5 10 15 Val Ala Ala Ala Gly Ala Ala Arg Arg Val Leu Leu Leu Leu Leu Leu 20 25 30 Gly Val Leu Ser Ala Arg Leu Arg Pro Gly Ala Leu Ala Thr Glu His 35 40 45 Tyr Ser Pro Leu Ser Leu Leu Lys Gln Glu Leu Gln His Arg Gln Gln 50 55 60 Gln Glu Ala Pro Ala Gly Gly Gly Gly Cys Ser Pro Gln Ser Gly Asp 65 70 75 80 Trp Gly Asp Gln Tyr Ser Ala Glu Cys Gly Glu Ser Ser Phe Leu Asn 85 90 95 Phe His Asp Ser Asp Cys Glu Pro Lys Gly Ser Ser Pro Cys Asp Ser 100 105 110 Leu Leu Ser Leu Asn Thr Glu Lys Ile Leu Ser Gln Ala Lys Ser Ile 115 120 125 Ala Glu Gln Lys Arg Phe Pro Phe Ala Thr Asp Asn Asp Ser Thr Asn 130 135 140 Glu Glu Leu Ala Ile Ala Tyr Val Leu Ile Gly Ser Gly Leu Tyr Asp 145 150 155 160 Glu Ala Ile Arg His Phe Ser Thr Met Leu Gln Ile Leu Ser Pro Leu 165 170 175 Gly Arg Ile Asn Glu Ala Val Asn Asp Leu Thr Lys Ala Ile Gln Leu 180 185 190 Gln Pro Ser Ala Arg Leu Tyr Arg His Arg Gly Thr Leu Tyr Phe Ile 195 200 205 Ser Glu Asp Tyr Ala Thr Ala His Glu Asp Phe Gln Gln Ser Leu Glu 210 215 220 Leu Asn Lys Asn Gln Pro Ile Ala Met Leu Tyr Lys Gly Leu Thr Phe 225 230 235 240 Phe His Arg Gly Leu Leu Lys Glu Ala Ile Glu Ser Phe Lys Glu Ala 245 250 255 Leu Lys Gln Lys Val Asp Phe Ile Asp Ala Tyr Lys Ser Leu Gly Gln 260 265 270 Ala Tyr Arg Glu Leu Gly Asn Phe Glu Ala Ala Thr Glu Ser Phe Gln 275 280 285 Lys Ala Leu Leu Leu Asn Gln Asn His Val Gln Thr Leu Gln Leu Arg 290 295 300 Gly Met Met Leu Tyr His His Gly Ser Leu Gln Glu Ala Leu Lys Asn 305 310 315 320 Phe Lys Arg Cys Leu Gln Leu Glu Pro Tyr Asn Glu Val Cys Gln Tyr 325 330 335 Met Lys Gly Leu Ser His Val Ala Met Gly Gln Phe Tyr Glu Gly Ile 340 345 350 Lys Ala Gln Thr Lys Val Met Leu Asn Asp Pro Leu Pro Gly Gln Lys 355 360 365 Ala Ser Pro Glu Tyr Leu Lys Val Lys Tyr Leu Arg Glu Tyr Ser Arg 370 375 380 Tyr Leu His Ala His Leu Asp Thr Pro Leu Thr Glu Tyr Asn Ile Asp 385 390 395 400 Val Asp Leu Pro Gly Ser Phe Lys Asp His Trp Ala Lys Asn Leu Pro 405 410 415 Phe Leu Ile Glu Asp Tyr Glu Glu Gln Pro Gly Leu Gln Pro His Ile 420 425 430 Lys Asp Val Leu His Gln Asn Phe Glu Ser Tyr Lys Pro Glu Val Gln 435 440 445 Glu Leu Ile Cys Val Ala Asp Arg Leu Gly Ser Leu Met Gln Tyr Glu 450 455 460 Thr Pro Gly Phe Leu Pro Asn Lys Arg Ile His Arg Ala Met Gly Leu 465 470 475 480 Ala Ala Leu Glu Val Met Gln Ala Val Gln Arg Thr Trp Thr Asn Ser 485 490 495 Lys Val Arg Met Asn Gly Lys Thr Arg Leu Met Gln Trp Arg Asp Met 500 505 510 Phe Asp Ile Ala Val Lys Trp Arg Arg Ile Ala Asp Pro Asp Gln Pro 515 520 525 Val Leu Trp Leu Asp Gln Met Pro Ala Arg Ser Leu Ser Arg Gly Phe 530 535 540 Asn Asn His Ile Asn Leu Ile Arg Gly Gln Val Ile Asn Met Arg Tyr 545 550 555 560 Leu Glu Tyr Phe Glu Lys Ile Leu His Phe Ile Lys Asp Arg Ile Leu 565 570 575 Val Tyr His Gly Ala Asn Asn Pro Lys Gly Leu Leu Glu Val Arg Glu 580 585 590 Ala Leu Glu Lys Val His Lys Val Glu Asp Leu Leu Pro Ile Met Lys 595 600 605 Phe Asn Thr Lys Thr Lys Asp Gly Phe Thr Val Asn Thr Lys Val Pro 610 615 620 Ser Leu Lys Asp Gln Gly Lys Glu Tyr Asp Gly Phe Thr Ile Thr Ile 625 630 635 640 Thr Gly Asp Lys Val Gly Asn Ile Leu Phe Ser Val Glu Thr Gln Thr 645 650 655 Thr Glu Glu Arg Thr Gln Leu Tyr His Ala Glu Ile Asp Ala Leu Tyr 660 665 670 Lys Asp Leu Thr Ala Lys Gly Lys Val Leu Ile Leu Ser Ser Glu Phe 675 680 685 Gly Glu Ala Asp Ala Val Cys Asn Leu Ile Leu Ser Leu Val Tyr Tyr 690 695 700 Phe Tyr Asn Leu Met Pro Leu Ser Arg Gly Ser Ser Val Ile Ala Tyr 705 710 715 720 Ser Val Ile Val Gly Ala Leu Met Ala Ser Gly Lys Glu Val Ala Gly 725 730 735 Lys Ile Pro Lys Gly Lys Leu Val Asp Phe Glu Ala Met Thr Ala Pro 740 745 750 Gly Ser Glu Ala Phe Ser Lys Val Ala Lys Ser Trp Met Asn Leu Lys 755 760 765 Ser Ile Ser Pro Ser Tyr Lys Thr Leu Pro Ser Val Ser Glu Thr Phe 770 775 780 Pro Thr Leu Arg Ser Met Ile Glu Val Leu Asn Thr Asp Ser Ser Pro 785 790 795 800 Arg Cys Leu Lys Lys Leu 805 <210> 303 <211> 4144 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (14)..(2926) <400> 303 atgcgctcgc atc atg gcg gct gag tgg gct tct cgt ttc tgg ctt tgg 49 Met Ala Ala Glu Trp Ala Ser Arg Phe Trp Leu Trp 1 5 10 gct acg ctg ctg att cct gcg gcc gcg gtc tac gaa gac caa gtg ggc 97 Ala Thr Leu Leu Ile Pro Ala Ala Ala Val Tyr Glu Asp Gln Val Gly 15 20 25 aag ttt gat tgg aga cag caa tat gtt ggg aag gtc aag ttt gcc tcc 145 Lys Phe Asp Trp Arg Gln Gln Tyr Val Gly Lys Val Lys Phe Ala Ser 30 35 40 ttg gaa ttt tcc cct gga tcc aag aag ttg gtt gta gcc aca gag aag 193 Leu Glu Phe Ser Pro Gly Ser Lys Lys Leu Val Val Ala Thr Glu Lys 45 50 55 60 aat gtg att gca gca tta aat tcc cga act ggg gag atc tat gtg atc 241 Asn Val Ile Ala Ala Leu Asn Ser Arg Thr Gly Glu Ile Tyr Val Ile 65 70 75 act gtg tcc aat gga ggc cga atc atg cgt tcc tgg gag act aac atc 289 Thr Val Ser Asn Gly Gly Arg Ile Met Arg Ser Trp Glu Thr Asn Ile 80 85 90 ggg ggc ctg aac tgg gag ata acc ctg gac agt ggc agt ttc cag gca 337 Gly Gly Leu Asn Trp Glu Ile Thr Leu Asp Ser Gly Ser Phe Gln Ala 95 100 105 ctt ggg ctg gtt ggc ctg cag gag tct gta agg tac atc gca gtc ctg 385 Leu Gly Leu Val Gly Leu Gln Glu Ser Val Arg Tyr Ile Ala Val Leu 110 115 120 aag aag act aca ctt gcc ctc cat cac ctc tcc agt ggg cac ctc aag 433 Lys Lys Thr Thr Leu Ala Leu His His Leu Ser Ser Gly His Leu Lys 125 130 135 140 tgg gtg gaa cat ctc cca gaa agt gac agc atc cac tac cag atg gtg 481 Trp Val Glu His Leu Pro Glu Ser Asp Ser Ile His Tyr Gln Met Val 145 150 155 tat tct tac ggc tct ggg gtg gtg tgg gcc ctc gga gtt gtt ccc ttc 529 Tyr Ser Tyr Gly Ser Gly Val Val Trp Ala Leu Gly Val Val Pro Phe 160 165 170 agc cat gtg aac att gtc aag ttt aat gtg gaa gat gga gag att gtt 577 Ser His Val Asn Ile Val Lys Phe Asn Val Glu Asp Gly Glu Ile Val 175 180 185 cag cag gtt agg gtt tca act ccg tgg ctg cag cac ctg tct gga gcc 625 Gln Gln Val Arg Val Ser Thr Pro Trp Leu Gln His Leu Ser Gly Ala 190 195 200 tgt ggt gtg gtg gat gag gct gtc ctg gtg tgt cct gac ccg agc tca 673 Cys Gly Val Val Asp Glu Ala Val Leu Val Cys Pro Asp Pro Ser Ser 205 210 215 220 cgt tcc ctc caa act ttg gct ctg gag acg gaa tgg gag ttg aga cag 721 Arg Ser Leu Gln Thr Leu Ala Leu Glu Thr Glu Trp Glu Leu Arg Gln 225 230 235 atc cca ctg cag tct ctc gac tta gaa ttt gga agt gga ttc caa ccc 769 Ile Pro Leu Gln Ser Leu Asp Leu Glu Phe Gly Ser Gly Phe Gln Pro 240 245 250 cgg gtc ctg cct acc cag ccc aac cca gtg gac gct tcc cgg gcc cag 817 Arg Val Leu Pro Thr Gln Pro Asn Pro Val Asp Ala Ser Arg Ala Gln 255 260 265 ttc ttc ctg cac ttg tcc cca agc cac tat gct ctg ctg cag tac cat 865 Phe Phe Leu His Leu Ser Pro Ser His Tyr Ala Leu Leu Gln Tyr His 270 275 280 tat gga acg ctg agt ttg ctt aaa aac ttc cca cag act gcc cta gtg 913 Tyr Gly Thr Leu Ser Leu Leu Lys Asn Phe Pro Gln Thr Ala Leu Val 285 290 295 300 agc ttt gcc acc act ggg gag aag acg gtg gct gca gtc atg gcc tgt 961 Ser Phe Ala Thr Thr Gly Glu Lys Thr Val Ala Ala Val Met Ala Cys 305 310 315 cgg aat gaa gtg cag aaa act agc aat tct gaa gat ggg tca atg ggg 1009 Arg Asn Glu Val Gln Lys Thr Ser Asn Ser Glu Asp Gly Ser Met Gly 320 325 330 agc ttt tcg gag aag tct agt tca aag gac tct ctg gct tgc ttc aat 1057 Ser Phe Ser Glu Lys Ser Ser Ser Lys Asp Ser Leu Ala Cys Phe Asn 335 340 345 cag acc tac acc att aac cta tac ctc gtg gag aca ggt cgg cgg ctg 1105 Gln Thr Tyr Thr Ile Asn Leu Tyr Leu Val Glu Thr Gly Arg Arg Leu 350 355 360 ctg gac acc acg ata aca ttt agc ctg gaa cag agc ggc act cgg cct 1153 Leu Asp Thr Thr Ile Thr Phe Ser Leu Glu Gln Ser Gly Thr Arg Pro 365 370 375 380 gag cgg ctg tat atc cag gtg ttc ttg aag aag gat gac tca gtg ggc 1201 Glu Arg Leu Tyr Ile Gln Val Phe Leu Lys Lys Asp Asp Ser Val Gly 385 390 395 tac cgg gct ttg gtg cag aca gag gat cat ctg cta ctt ttc ctg cag 1249 Tyr Arg Ala Leu Val Gln Thr Glu Asp His Leu Leu Leu Phe Leu Gln 400 405 410 cag ttg gca ggg aag gtg gtg ctg tgg agc cgt gag gag tcc ctg gca 1297 Gln Leu Ala Gly Lys Val Val Leu Trp Ser Arg Glu Glu Ser Leu Ala 415 420 425 gaa gtg gtg tgc cta gag atg gtg gac ctc ccc ctg act ggg gca cag 1345 Glu Val Val Cys Leu Glu Met Val Asp Leu Pro Leu Thr Gly Ala Gln 430 435 440 gcc gag ctg gaa gga gaa ttt ggc aaa aag gca gat ggc ttg ctg ggg 1393 Ala Glu Leu Glu Gly Glu Phe Gly Lys Lys Ala Asp Gly Leu Leu Gly 445 450 455 460 atg ttc ctg aaa cgc ctc tcg tct cag ctt atc ctg ctg caa gca tgg 1441 Met Phe Leu Lys Arg Leu Ser Ser Gln Leu Ile Leu Leu Gln Ala Trp 465 470 475 act tcc cac ctc tgg aaa atg ttt tat gat gct cgg aag ccc cgg agt 1489 Thr Ser His Leu Trp Lys Met Phe Tyr Asp Ala Arg Lys Pro Arg Ser 480 485 490 cag att aag aat gag atc aac att gac acc ctg gcc aga gat gaa ttc 1537 Gln Ile Lys Asn Glu Ile Asn Ile Asp Thr Leu Ala Arg Asp Glu Phe 495 500 505 aac ctc cag aag atg atg gtg atg gta aca gcc tca ggc aag ctt ttt 1585 Asn Leu Gln Lys Met Met Val Met Val Thr Ala Ser Gly Lys Leu Phe 510 515 520 ggc att gag agc agc tct ggc acc atc ctg tgg aaa cag tat cta ccc 1633 Gly Ile Glu Ser Ser Ser Gly Thr Ile Leu Trp Lys Gln Tyr Leu Pro 525 530 535 540 aat gtc aag ccc gac tcc tcc tat aaa ctg atg gtc cag aga act act 1681 Asn Val Lys Pro Asp Ser Ser Tyr Lys Leu Met Val Gln Arg Thr Thr 545 550 555 gct cat ttc ccc cat ccc cca cag tgc acc ctg ctg gtg aag gac aag 1729 Ala His Phe Pro His Pro Pro Gln Cys Thr Leu Leu Val Lys Asp Lys 560 565 570 gag tcg gga atg agt tct ctg tat gtc ttc aat ccc att ttt ggg aag 1777 Glu Ser Gly Met Ser Ser Leu Tyr Val Phe Asn Pro Ile Phe Gly Lys 575 580 585 tgg agt cag gta gct ccc cca gtg ctg aag cgc ccc atc ttg cag tcc 1825 Trp Ser Gln Val Ala Pro Pro Val Leu Lys Arg Pro Ile Leu Gln Ser 590 595 600 ttg ctt ctc cca gtc atg gat caa gac tac gcc aag gtg ttg ctg ttg 1873 Leu Leu Leu Pro Val Met Asp Gln Asp Tyr Ala Lys Val Leu Leu Leu 605 610 615 620 ata gat gat gaa tac aag gtc aca gct ttt cca gcc act cgg aat gtc 1921 Ile Asp Asp Glu Tyr Lys Val Thr Ala Phe Pro Ala Thr Arg Asn Val 625 630 635 ttg cga cag cta cat gag ctt gcc cct tcc atc ttc ttc tat ttg gtg 1969 Leu Arg Gln Leu His Glu Leu Ala Pro Ser Ile Phe Phe Tyr Leu Val 640 645 650 gat gca gag cag gga cgg ctg tgt gga tat cgg ctt cga aag gat ctc 2017 Asp Ala Glu Gln Gly Arg Leu Cys Gly Tyr Arg Leu Arg Lys Asp Leu 655 660 665 acc act gag ctg agt tgg gag ctg acc att ccc cca gaa gta cag cgg 2065 Thr Thr Glu Leu Ser Trp Glu Leu Thr Ile Pro Pro Glu Val Gln Arg 670 675 680 atc gtc aag gtg aag ggg aaa cgc agc agt gag cac gtt cat tcc cag 2113 Ile Val Lys Val Lys Gly Lys Arg Ser Ser Glu His Val His Ser Gln 685 690 695 700 ggc cat gtg atg ggg gac cgc agt gtg ctc tac aag agc ctg aac ccc 2161 Gly His Val Met Gly Asp Arg Ser Val Leu Tyr Lys Ser Leu Asn Pro 705 710 715 aac ctg ctg gcc gtg gtg aca gag agc acg gac gcg cac cat gag cgc 2209 Asn Leu Leu Ala Val Val Thr Glu Ser Thr Asp Ala His His Glu Arg 720 725 730 acc ttt att ggc atc ttc ctc att gat ggc gtc act ggg cgt atc att 2257 Thr Phe Ile Gly Ile Phe Leu Ile Asp Gly Val Thr Gly Arg Ile Ile 735 740 745 cac tcc tct gtg cag aag aaa gcc aaa ggc cct gtc cat atc gtg cat 2305 His Ser Ser Val Gln Lys Lys Ala Lys Gly Pro Val His Ile Val His 750 755 760 tca gag aac tgg gtg gtg tac cag tac tgg aac acc aag gct cgg cgc 2353 Ser Glu Asn Trp Val Val Tyr Gln Tyr Trp Asn Thr Lys Ala Arg Arg 765 770 775 780 aac gag ttt acc gta ctg gag ctc tat gag ggc act gag caa tac aac 2401 Asn Glu Phe Thr Val Leu Glu Leu Tyr Glu Gly Thr Glu Gln Tyr Asn 785 790 795 gcc acc gcc ttc agc ttc ctg gac cgc ccc cag ctg ccc cag gtc ctc 2449 Ala Thr Ala Phe Ser Phe Leu Asp Arg Pro Gln Leu Pro Gln Val Leu 800 805 810 cag cag tcc tat atc ttc ccg tcc tcc atc agt gcc atg gag gcc acc 2497 Gln Gln Ser Tyr Ile Phe Pro Ser Ser Ile Ser Ala Met Glu Ala Thr 815 820 825 atc acc gaa cgg ggc atc acc agc cga cac ctg ctg att gga cta cct 2545 Ile Thr Glu Arg Gly Ile Thr Ser Arg His Leu Leu Ile Gly Leu Pro 830 835 840 tct gga gca att ctt tcc ctt cct aag gct ttg ctg gat ccc cgc cgc 2593 Ser Gly Ala Ile Leu Ser Leu Pro Lys Ala Leu Leu Asp Pro Arg Arg 845 850 855 860 ccc gag atc cca aca gaa caa agc aga gag gag aac tta atc ccg tat 2641 Pro Glu Ile Pro Thr Glu Gln Ser Arg Glu Glu Asn Leu Ile Pro Tyr 865 870 875 tct cca gat gta cag ata cac gca gag cga ttc atc aac tat aac cag 2689 Ser Pro Asp Val Gln Ile His Ala Glu Arg Phe Ile Asn Tyr Asn Gln 880 885 890 aca gtt tct cga atg cga ggt atc tac aca gct ccc tcg ggt ctg gag 2737 Thr Val Ser Arg Met Arg Gly Ile Tyr Thr Ala Pro Ser Gly Leu Glu 895 900 905 tcc act tgt ttg gtt gtg gcc tat ggt ttg gac att tac caa act cga 2785 Ser Thr Cys Leu Val Val Ala Tyr Gly Leu Asp Ile Tyr Gln Thr Arg 910 915 920 gtc tac cca tcc aag cag ttt gac gtt ctg aag gat gac tat gac tac 2833 Val Tyr Pro Ser Lys Gln Phe Asp Val Leu Lys Asp Asp Tyr Asp Tyr 925 930 935 940 gtg tta atc agc agc gtc ctc ttt ggc ctg gtt ttt gcc acc atg atc 2881 Val Leu Ile Ser Ser Val Leu Phe Gly Leu Val Phe Ala Thr Met Ile 945 950 955 act aag aga ctg gca cag gtg aag ctc ctg aat cgg gcc tgg cga 2926 Thr Lys Arg Leu Ala Gln Val Lys Leu Leu Asn Arg Ala Trp Arg 960 965 970 taaagaacaa agactgtgcc taaaagtgga gagccagggg agtgtgggtc agataagcag 2986 ctacagctgc agtttggtgg attggtggag tatgtgtgtg tgtcagtgct cagctaagaa 3046 ctgtagggaa gatggatgac cttcacgcag aactcctttt gggatataca tgatgcagaa 3106 aggatcctac atggagagag acagaactct ctcagctgac actctcagag attcctgatg 3166 ggctttctct tgaagtccaa aggcgtctgc attgtttcct ttctttgccc atccatgaat 3226 gttctgtttt gttttgtttt ttttaataag aattccggct gatttttgtg aggcctgttt 3286 aaattgactt tactttgcct tttgtgtttc tcaattttat ctagaaatct ttctgacttt 3346 ttccatctct tgcttcaaag taagagggga actctccttg ccgactccac cttataggta 3406 catttggtgt tttgcactgg gaagaaatag gatccatcct tagctgaggc ttgaggactg 3466 atccagcctc tcatggcttc cctccaaagt aacttagggt tgagggatct atatgtgatg 3526 tcaaaactta ctttaaacct ctagtttcgt gctgtcattt attaggctgg gccaccaaat 3586 ctgtttcaat ttatcagaag ccaagtgcat actagcgtct tgtttgttgc ccattgccta 3646 tacttttcac ctgagatgtg tgagttggga ccttttaaaa actactgaat tgtctgagcc 3706 ttgaagacat ttccagggag aagagataat ctctcatttc acccacaggc tggtctaatc 3766 ataacctagt taaagatgtc cttgtttaag aaccccatta tttattttta gtttttaata 3826 taaattaaca tgtgggtcat tatatttctc cttaaatgag gaaattttaa attttattga 3886 tctaaccttt gaagctttaa aaaaggagaa agagggtagg ggtgggaaac tggcatactg 3946 tgtgtatagc actgccgatt ggctaggcca ctgtgtctct gctacaaatt aaagaaatcc 4006 taaaagtttt ccttggtcat agagttgggg aatgacagaa tttttctttg ttgtgaaatg 4066 tatgtacaga gtagaccatc tctagccctg tggtgaaaga ggtacactcg aatgtttgca 4126 taaagcaagt gacaaatg 4144 <210> 304 <211> 971 <212> PRT <213> Homo sapiens <400> 304 Met Ala Ala Glu Trp Ala Ser Arg Phe Trp Leu Trp Ala Thr Leu Leu 1 5 10 15 Ile Pro Ala Ala Ala Val Tyr Glu Asp Gln Val Gly Lys Phe Asp Trp 20 25 30 Arg Gln Gln Tyr Val Gly Lys Val Lys Phe Ala Ser Leu Glu Phe Ser 35 40 45 Pro Gly Ser Lys Lys Leu Val Val Ala Thr Glu Lys Asn Val Ile Ala 50 55 60 Ala Leu Asn Ser Arg Thr Gly Glu Ile Tyr Val Ile Thr Val Ser Asn 65 70 75 80 Gly Gly Arg Ile Met Arg Ser Trp Glu Thr Asn Ile Gly Gly Leu Asn 85 90 95 Trp Glu Ile Thr Leu Asp Ser Gly Ser Phe Gln Ala Leu Gly Leu Val 100 105 110 Gly Leu Gln Glu Ser Val Arg Tyr Ile Ala Val Leu Lys Lys Thr Thr 115 120 125 Leu Ala Leu His His Leu Ser Ser Gly His Leu Lys Trp Val Glu His 130 135 140 Leu Pro Glu Ser Asp Ser Ile His Tyr Gln Met Val Tyr Ser Tyr Gly 145 150 155 160 Ser Gly Val Val Trp Ala Leu Gly Val Val Pro Phe Ser His Val Asn 165 170 175 Ile Val Lys Phe Asn Val Glu Asp Gly Glu Ile Val Gln Gln Val Arg 180 185 190 Val Ser Thr Pro Trp Leu Gln His Leu Ser Gly Ala Cys Gly Val Val 195 200 205 Asp Glu Ala Val Leu Val Cys Pro Asp Pro Ser Ser Arg Ser Leu Gln 210 215 220 Thr Leu Ala Leu Glu Thr Glu Trp Glu Leu Arg Gln Ile Pro Leu Gln 225 230 235 240 Ser Leu Asp Leu Glu Phe Gly Ser Gly Phe Gln Pro Arg Val Leu Pro 245 250 255 Thr Gln Pro Asn Pro Val Asp Ala Ser Arg Ala Gln Phe Phe Leu His 260 265 270 Leu Ser Pro Ser His Tyr Ala Leu Leu Gln Tyr His Tyr Gly Thr Leu 275 280 285 Ser Leu Leu Lys Asn Phe Pro Gln Thr Ala Leu Val Ser Phe Ala Thr 290 295 300 Thr Gly Glu Lys Thr Val Ala Ala Val Met Ala Cys Arg Asn Glu Val 305 310 315 320 Gln Lys Thr Ser Asn Ser Glu Asp Gly Ser Met Gly Ser Phe Ser Glu 325 330 335 Lys Ser Ser Ser Lys Asp Ser Leu Ala Cys Phe Asn Gln Thr Tyr Thr 340 345 350 Ile Asn Leu Tyr Leu Val Glu Thr Gly Arg Arg Leu Leu Asp Thr Thr 355 360 365 Ile Thr Phe Ser Leu Glu Gln Ser Gly Thr Arg Pro Glu Arg Leu Tyr 370 375 380 Ile Gln Val Phe Leu Lys Lys Asp Asp Ser Val Gly Tyr Arg Ala Leu 385 390 395 400 Val Gln Thr Glu Asp His Leu Leu Leu Phe Leu Gln Gln Leu Ala Gly 405 410 415 Lys Val Val Leu Trp Ser Arg Glu Glu Ser Leu Ala Glu Val Val Cys 420 425 430 Leu Glu Met Val Asp Leu Pro Leu Thr Gly Ala Gln Ala Glu Leu Glu 435 440 445 Gly Glu Phe Gly Lys Lys Ala Asp Gly Leu Leu Gly Met Phe Leu Lys 450 455 460 Arg Leu Ser Ser Gln Leu Ile Leu Leu Gln Ala Trp Thr Ser His Leu 465 470 475 480 Trp Lys Met Phe Tyr Asp Ala Arg Lys Pro Arg Ser Gln Ile Lys Asn 485 490 495 Glu Ile Asn Ile Asp Thr Leu Ala Arg Asp Glu Phe Asn Leu Gln Lys 500 505 510 Met Met Val Met Val Thr Ala Ser Gly Lys Leu Phe Gly Ile Glu Ser 515 520 525 Ser Ser Gly Thr Ile Leu Trp Lys Gln Tyr Leu Pro Asn Val Lys Pro 530 535 540 Asp Ser Ser Tyr Lys Leu Met Val Gln Arg Thr Thr Ala His Phe Pro 545 550 555 560 His Pro Pro Gln Cys Thr Leu Leu Val Lys Asp Lys Glu Ser Gly Met 565 570 575 Ser Ser Leu Tyr Val Phe Asn Pro Ile Phe Gly Lys Trp Ser Gln Val 580 585 590 Ala Pro Pro Val Leu Lys Arg Pro Ile Leu Gln Ser Leu Leu Leu Pro 595 600 605 Val Met Asp Gln Asp Tyr Ala Lys Val Leu Leu Leu Ile Asp Asp Glu 610 615 620 Tyr Lys Val Thr Ala Phe Pro Ala Thr Arg Asn Val Leu Arg Gln Leu 625 630 635 640 His Glu Leu Ala Pro Ser Ile Phe Phe Tyr Leu Val Asp Ala Glu Gln 645 650 655 Gly Arg Leu Cys Gly Tyr Arg Leu Arg Lys Asp Leu Thr Thr Glu Leu 660 665 670 Ser Trp Glu Leu Thr Ile Pro Pro Glu Val Gln Arg Ile Val Lys Val 675 680 685 Lys Gly Lys Arg Ser Ser Glu His Val His Ser Gln Gly His Val Met 690 695 700 Gly Asp Arg Ser Val Leu Tyr Lys Ser Leu Asn Pro Asn Leu Leu Ala 705 710 715 720 Val Val Thr Glu Ser Thr Asp Ala His His Glu Arg Thr Phe Ile Gly 725 730 735 Ile Phe Leu Ile Asp Gly Val Thr Gly Arg Ile Ile His Ser Ser Val 740 745 750 Gln Lys Lys Ala Lys Gly Pro Val His Ile Val His Ser Glu Asn Trp 755 760 765 Val Val Tyr Gln Tyr Trp Asn Thr Lys Ala Arg Arg Asn Glu Phe Thr 770 775 780 Val Leu Glu Leu Tyr Glu Gly Thr Glu Gln Tyr Asn Ala Thr Ala Phe 785 790 795 800 Ser Phe Leu Asp Arg Pro Gln Leu Pro Gln Val Leu Gln Gln Ser Tyr 805 810 815 Ile Phe Pro Ser Ser Ile Ser Ala Met Glu Ala Thr Ile Thr Glu Arg 820 825 830 Gly Ile Thr Ser Arg His Leu Leu Ile Gly Leu Pro Ser Gly Ala Ile 835 840 845 Leu Ser Leu Pro Lys Ala Leu Leu Asp Pro Arg Arg Pro Glu Ile Pro 850 855 860 Thr Glu Gln Ser Arg Glu Glu Asn Leu Ile Pro Tyr Ser Pro Asp Val 865 870 875 880 Gln Ile His Ala Glu Arg Phe Ile Asn Tyr Asn Gln Thr Val Ser Arg 885 890 895 Met Arg Gly Ile Tyr Thr Ala Pro Ser Gly Leu Glu Ser Thr Cys Leu 900 905 910 Val Val Ala Tyr Gly Leu Asp Ile Tyr Gln Thr Arg Val Tyr Pro Ser 915 920 925 Lys Gln Phe Asp Val Leu Lys Asp Asp Tyr Asp Tyr Val Leu Ile Ser 930 935 940 Ser Val Leu Phe Gly Leu Val Phe Ala Thr Met Ile Thr Lys Arg Leu 945 950 955 960 Ala Gln Val Lys Leu Leu Asn Arg Ala Trp Arg 965 970 <210> 305 <211> 1085 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(813) <400> 305 atg tcg ccg ctg ctg ggg ctc cgg tcc gag ctg cag gac acc tgc acc 48 Met Ser Pro Leu Leu Gly Leu Arg Ser Glu Leu Gln Asp Thr Cys Thr 1 5 10 15 tcg ctg gga ctg atg ctg tcg gtg gtg ctg ctc atg ggg ctg gcc cgc 96 Ser Leu Gly Leu Met Leu Ser Val Val Leu Leu Met Gly Leu Ala Arg 20 25 30 gta gtc gcc cgg cag cag ctg cac agg ccg gtg gcc cac gcc ttc gtc 144 Val Val Ala Arg Gln Gln Leu His Arg Pro Val Ala His Ala Phe Val 35 40 45 ctg gag ttt cta gcc acc ttc cag ctc tgc tgc tgc acc cac gag ctg 192 Leu Glu Phe Leu Ala Thr Phe Gln Leu Cys Cys Cys Thr His Glu Leu 50 55 60 caa ctg ctg agc gaa cag cac ccc gcg cac ccc acc tgg acg ctg acg 240 Gln Leu Leu Ser Glu Gln His Pro Ala His Pro Thr Trp Thr Leu Thr 65 70 75 80 ctc gtc tac ttc ttc tcg ctt gtg cat ggc ctg act ctg gtg ggc acg 288 Leu Val Tyr Phe Phe Ser Leu Val His Gly Leu Thr Leu Val Gly Thr 85 90 95 tcc agc aac ccg tgc ggc gtg atg atg cag atg atg ctg ggg ggc atg 336 Ser Ser Asn Pro Cys Gly Val Met Met Gln Met Met Leu Gly Gly Met 100 105 110 tcc ccc gag acg ggt gcg gtg agg cta ttg gct cag ctg gtt agt gcc 384 Ser Pro Glu Thr Gly Ala Val Arg Leu Leu Ala Gln Leu Val Ser Ala 115 120 125 ctg tgc agc agg tac tgc aca agc gcc ttg tgg agc ttg ggt ctg acc 432 Leu Cys Ser Arg Tyr Cys Thr Ser Ala Leu Trp Ser Leu Gly Leu Thr 130 135 140 cag tat cac gtc agc gag agg agc ttc gct tgc aag aat ccc atc cga 480 Gln Tyr His Val Ser Glu Arg Ser Phe Ala Cys Lys Asn Pro Ile Arg 145 150 155 160 gtc gac ttg ctc aaa gcg gtc atc aca gag gcc gtc tgc tcc ttt ctc 528 Val Asp Leu Leu Lys Ala Val Ile Thr Glu Ala Val Cys Ser Phe Leu 165 170 175 ttc cac agc gct ctg ctg cac ttc cag gaa gtc cga acc aag ctt cgt 576 Phe His Ser Ala Leu Leu His Phe Gln Glu Val Arg Thr Lys Leu Arg 180 185 190 atc cac ctg ctg gct gca ctc atc acc ttt ttg gtc tat gca gga gga 624 Ile His Leu Leu Ala Ala Leu Ile Thr Phe Leu Val Tyr Ala Gly Gly 195 200 205 agt cta aca gga gct gta ttt aat cca gct ttg gca ctt tcg cta cat 672 Ser Leu Thr Gly Ala Val Phe Asn Pro Ala Leu Ala Leu Ser Leu His 210 215 220 ttc atg tgt ttt gat gaa gca ttc cct cag ttt ttt ata gta tac tgg 720 Phe Met Cys Phe Asp Glu Ala Phe Pro Gln Phe Phe Ile Val Tyr Trp 225 230 235 240 ctg gct cct tct tta ggt ata ttg ttg atg att ttg atg ttc agc ttt 768 Leu Ala Pro Ser Leu Gly Ile Leu Leu Met Ile Leu Met Phe Ser Phe 245 250 255 ttc ctt cca tgg ctg cat aac aac cat aca att aat aaa aag gaa 813 Phe Leu Pro Trp Leu His Asn Asn His Thr Ile Asn Lys Lys Glu 260 265 270 taactgttcc aaagactcag actaacatac aggacagtcc agctggatgt gataaagatt 873 ttatcacctc atatggaaaa caccggctgc actggattca tcagtgttaa cttcctttga 933 ggaagctgcc ttatagtttt catcactggg actttaaaaa aaaattactg tgaaaatgag 993 gtattctgta cttctcagtt aagacttgtt ctttgagtga tgtattaaat gctgctagaa 1053 aagcctcatt acattaaata taaatcaatc tt 1085 <210> 306 <211> 271 <212> PRT <213> Homo sapiens <400> 306 Met Ser Pro Leu Leu Gly Leu Arg Ser Glu Leu Gln Asp Thr Cys Thr 1 5 10 15 Ser Leu Gly Leu Met Leu Ser Val Val Leu Leu Met Gly Leu Ala Arg 20 25 30 Val Val Ala Arg Gln Gln Leu His Arg Pro Val Ala His Ala Phe Val 35 40 45 Leu Glu Phe Leu Ala Thr Phe Gln Leu Cys Cys Cys Thr His Glu Leu 50 55 60 Gln Leu Leu Ser Glu Gln His Pro Ala His Pro Thr Trp Thr Leu Thr 65 70 75 80 Leu Val Tyr Phe Phe Ser Leu Val His Gly Leu Thr Leu Val Gly Thr 85 90 95 Ser Ser Asn Pro Cys Gly Val Met Met Gln Met Met Leu Gly Gly Met 100 105 110 Ser Pro Glu Thr Gly Ala Val Arg Leu Leu Ala Gln Leu Val Ser Ala 115 120 125 Leu Cys Ser Arg Tyr Cys Thr Ser Ala Leu Trp Ser Leu Gly Leu Thr 130 135 140 Gln Tyr His Val Ser Glu Arg Ser Phe Ala Cys Lys Asn Pro Ile Arg 145 150 155 160 Val Asp Leu Leu Lys Ala Val Ile Thr Glu Ala Val Cys Ser Phe Leu 165 170 175 Phe His Ser Ala Leu Leu His Phe Gln Glu Val Arg Thr Lys Leu Arg 180 185 190 Ile His Leu Leu Ala Ala Leu Ile Thr Phe Leu Val Tyr Ala Gly Gly 195 200 205 Ser Leu Thr Gly Ala Val Phe Asn Pro Ala Leu Ala Leu Ser Leu His 210 215 220 Phe Met Cys Phe Asp Glu Ala Phe Pro Gln Phe Phe Ile Val Tyr Trp 225 230 235 240 Leu Ala Pro Ser Leu Gly Ile Leu Leu Met Ile Leu Met Phe Ser Phe 245 250 255 Phe Leu Pro Trp Leu His Asn Asn His Thr Ile Asn Lys Lys Glu 260 265 270 <210> 307 <211> 2048 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (97)..(897) <400> 307 aaaacttccg gtgcctgcag agctcggagc ggcggaggca gagaccgagg ctgcaccggc 60 agaggctgcg gggcggacgc gcgggccggc gcagcc atg gtg aag att agc ttc 114 Met Val Lys Ile Ser Phe 1 5 cag ccc gcc gtg gct ggc atc aag ggc gac aag gct gac aag gcg tcg 162 Gln Pro Ala Val Ala Gly Ile Lys Gly Asp Lys Ala Asp Lys Ala Ser 10 15 20 gcg tcg gcc cct gcg ccg gcc tcg gcc acc gag atc ctg ctg acg ccg 210 Ala Ser Ala Pro Ala Pro Ala Ser Ala Thr Glu Ile Leu Leu Thr Pro 25 30 35 gct agg gag gag cag ccc cca caa cat cga tcc aag agg ggg ggc tca 258 Ala Arg Glu Glu Gln Pro Pro Gln His Arg Ser Lys Arg Gly Gly Ser 40 45 50 gtg ggc ggc gtg tgc tac ctg tcg atg ggc atg gtc gtg ctg ctc atg 306 Val Gly Gly Val Cys Tyr Leu Ser Met Gly Met Val Val Leu Leu Met 55 60 65 70 ggc ctc gtg ttc gcc tct gtc tac atc tac aga tac ttc ttc ctt gcg 354 Gly Leu Val Phe Ala Ser Val Tyr Ile Tyr Arg Tyr Phe Phe Leu Ala 75 80 85 cag ctg gcc cga gat aac ttc ttc cgc tgt ggt gtg ctg tat gag gac 402 Gln Leu Ala Arg Asp Asn Phe Phe Arg Cys Gly Val Leu Tyr Glu Asp 90 95 100 tcc ctg tcc tcc cag gtc cgg act cag atg gag ctg gaa gag gat gtg 450 Ser Leu Ser Ser Gln Val Arg Thr Gln Met Glu Leu Glu Glu Asp Val 105 110 115 aaa atc tac ctc gac gag aac tac gag cgc atc aac gtg cct gtg ccc 498 Lys Ile Tyr Leu Asp Glu Asn Tyr Glu Arg Ile Asn Val Pro Val Pro 120 125 130 cag ttt ggc ggc ggt gac cct gca gac atc atc cat gac ttc cag cgg 546 Gln Phe Gly Gly Gly Asp Pro Ala Asp Ile Ile His Asp Phe Gln Arg 135 140 145 150 ggt ctg act gcg tac cat gat atc tcc ctg gac aag tgc tat gtc atc 594 Gly Leu Thr Ala Tyr His Asp Ile Ser Leu Asp Lys Cys Tyr Val Ile 155 160 165 gaa ctc aac acc acc att gtg ctg ccc cct cgc aac ttc tgg gag ctc 642 Glu Leu Asn Thr Thr Ile Val Leu Pro Pro Arg Asn Phe Trp Glu Leu 170 175 180 ctc atg aac gtg aag agg ggg acc tac ctg ccg cag acg tac atc atc 690 Leu Met Asn Val Lys Arg Gly Thr Tyr Leu Pro Gln Thr Tyr Ile Ile 185 190 195 cag gag gag atg gtg gtc acg gag cat gtc agt gac aag gag gcc ctg 738 Gln Glu Glu Met Val Val Thr Glu His Val Ser Asp Lys Glu Ala Leu 200 205 210 ggg tcc ttc atc tac cac ctg tgc aac ggg aaa gac acc tac cgg ctc 786 Gly Ser Phe Ile Tyr His Leu Cys Asn Gly Lys Asp Thr Tyr Arg Leu 215 220 225 230 cgg cgc cgg gca acg cgg agg cgg atc aac aag cgt ggg gcc aag aac 834 Arg Arg Arg Ala Thr Arg Arg Arg Ile Asn Lys Arg Gly Ala Lys Asn 235 240 245 tgc aat gcc atc cgc cac ttc gag aac acc ttc gtg gtg gag acg ctc 882 Cys Asn Ala Ile Arg His Phe Glu Asn Thr Phe Val Val Glu Thr Leu 250 255 260 atc tgc ggg gtg gtg tgaggccctc ctcccccaga accccctgcc gtgttcctct 937 Ile Cys Gly Val Val 265 tttcttcttt ccggctgctc tctggccctc ctccttcccc ctgcttagct tgtactttgg 997 acgcgtttct atagaggtga catgtctctc cattcctctc caaccctgcc cacctccctg 1057 taccagagct gtgatctctc ggtggggggc ccatctctgc tgacctgggt gtggcggagg 1117 gagaggcgat gctgcaaagt gttttctgtg tcccactgtc ttgaagctgg gcctgccaaa 1177 gcctgggccc acagctgcac cggcagccca aggggaagga ccggttgggg gagccgggca 1237 tgtgaggccc tgggcaaggg gatggggctg tgggggcggg gcggcatggg cttcagaagt 1297 atctgcacaa ttagaaaagt cctcagaagc tttttcttgg agggtacact ttcttcactg 1357 tccctattcc tagacctggg gcttgagctg aggatgggac gatgtgccca gggagggacc 1417 caccagagca caagagaagg tggctacctg ggggtgtccc agggactctg tcagtgcctt 1477 cagcccacca gcaggagctt ggagtttggg gagtggggat gagtccgtca agcacaactg 1537 ttctctgagt ggaaccaaag aagcaaggag ctaggacccc cagtcctgcc ccccaggagc 1597 acaagcaggg tcccctcagt caaggcagtg ggatgggcgg ctgaggaacg gggcaggcaa 1657 ggtcactgct cagtcacgtc cacgggggac gagccgtggg ttctgctgag taggtggagc 1717 tcattgcttt ctccaagctt ggaactgttt tgaaagataa cacagaggga aagggagagc 1777 cacctggtac ttgtccaccc tgcctcctct gttctgaaat tccatccccc tcagcttagg 1837 ggaatgcacc tttttccctt tccttctcac ttttgcatgt ttttactgat cattcgatat 1897 gctaaccgtt ctcagccctg agccttggag aggagggctg taacgccttc agtcagtctc 1957 tggggatgaa actcttaaat gctttgtata ttttctcaat tagatctctt ttcagaagtg 2017 tctatagaac aataaaaatc ttttacttct g 2048 <210> 308 <211> 267 <212> PRT <213> Homo sapiens <400> 308 Met Val Lys Ile Ser Phe Gln Pro Ala Val Ala Gly Ile Lys Gly Asp 1 5 10 15 Lys Ala Asp Lys Ala Ser Ala Ser Ala Pro Ala Pro Ala Ser Ala Thr 20 25 30 Glu Ile Leu Leu Thr Pro Ala Arg Glu Glu Gln Pro Pro Gln His Arg 35 40 45 Ser Lys Arg Gly Gly Ser Val Gly Gly Val Cys Tyr Leu Ser Met Gly 50 55 60 Met Val Val Leu Leu Met Gly Leu Val Phe Ala Ser Val Tyr Ile Tyr 65 70 75 80 Arg Tyr Phe Phe Leu Ala Gln Leu Ala Arg Asp Asn Phe Phe Arg Cys 85 90 95 Gly Val Leu Tyr Glu Asp Ser Leu Ser Ser Gln Val Arg Thr Gln Met 100 105 110 Glu Leu Glu Glu Asp Val Lys Ile Tyr Leu Asp Glu Asn Tyr Glu Arg 115 120 125 Ile Asn Val Pro Val Pro Gln Phe Gly Gly Gly Asp Pro Ala Asp Ile 130 135 140 Ile His Asp Phe Gln Arg Gly Leu Thr Ala Tyr His Asp Ile Ser Leu 145 150 155 160 Asp Lys Cys Tyr Val Ile Glu Leu Asn Thr Thr Ile Val Leu Pro Pro 165 170 175 Arg Asn Phe Trp Glu Leu Leu Met Asn Val Lys Arg Gly Thr Tyr Leu 180 185 190 Pro Gln Thr Tyr Ile Ile Gln Glu Glu Met Val Val Thr Glu His Val 195 200 205 Ser Asp Lys Glu Ala Leu Gly Ser Phe Ile Tyr His Leu Cys Asn Gly 210 215 220 Lys Asp Thr Tyr Arg Leu Arg Arg Arg Ala Thr Arg Arg Arg Ile Asn 225 230 235 240 Lys Arg Gly Ala Lys Asn Cys Asn Ala Ile Arg His Phe Glu Asn Thr 245 250 255 Phe Val Val Glu Thr Leu Ile Cys Gly Val Val 260 265 <210> 309 <211> 2682 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (45)..(1466) <400> 309 aggtccgcgg ctgctgctgc gtccgacccc cggccggcgc gggt atg gag ctt ggg 56 Met Glu Leu Gly 1 ggt cac tgg gac atg aac tcg gcc ccg agg ctg gtc tcg gag acc gca 104 Gly His Trp Asp Met Asn Ser Ala Pro Arg Leu Val Ser Glu Thr Ala 5 10 15 20 gag cgg aaa cag gag cag aag aca gga acc gag gcg gag gct gcc gac 152 Glu Arg Lys Gln Glu Gln Lys Thr Gly Thr Glu Ala Glu Ala Ala Asp 25 30 35 tcc ggt gcc gtc gga gcc cgc cgc ttc ctg ctc tgt ctc tac ttg gtg 200 Ser Gly Ala Val Gly Ala Arg Arg Phe Leu Leu Cys Leu Tyr Leu Val 40 45 50 ggc ttc ttg gat ttg ttt ggt gtc agc atg gtt gtg cct tta ttg agc 248 Gly Phe Leu Asp Leu Phe Gly Val Ser Met Val Val Pro Leu Leu Ser 55 60 65 ctt cat gtc aag tcc ctt gga gca agt cca aca gtt gct gga ata gta 296 Leu His Val Lys Ser Leu Gly Ala Ser Pro Thr Val Ala Gly Ile Val 70 75 80 ggc tcc tcc tat ggc att ttg caa ctc ttt tct agc aca ttg gtg ggc 344 Gly Ser Ser Tyr Gly Ile Leu Gln Leu Phe Ser Ser Thr Leu Val Gly 85 90 95 100 tgc tgg agc gat gta gtg gga aga cgg tct tcc ttg ctg gca tgc att 392 Cys Trp Ser Asp Val Val Gly Arg Arg Ser Ser Leu Leu Ala Cys Ile 105 110 115 cta ctc agt gct ctg ggc tat ctc ctt ctc gga gca gcc acc aat gtg 440 Leu Leu Ser Ala Leu Gly Tyr Leu Leu Leu Gly Ala Ala Thr Asn Val 120 125 130 ttt ctg ttt gtc ctg gct aga gtc ccg gca ggt att ttt aaa cac act 488 Phe Leu Phe Val Leu Ala Arg Val Pro Ala Gly Ile Phe Lys His Thr 135 140 145 ctc tcc atc tca agg gct cta ctt tct gat gtg gtt cca gag aag gaa 536 Leu Ser Ile Ser Arg Ala Leu Leu Ser Asp Val Val Pro Glu Lys Glu 150 155 160 cgg ccg ctt gta atc gga cac ttc aac aca gcc tcc ggt gtg ggc ttc 584 Arg Pro Leu Val Ile Gly His Phe Asn Thr Ala Ser Gly Val Gly Phe 165 170 175 180 atc ttg ggc ccc gtg gtc ggt ggc tat ccc act gaa tta gag gat ggg 632 Ile Leu Gly Pro Val Val Gly Gly Tyr Pro Thr Glu Leu Glu Asp Gly 185 190 195 ttt tat ctc aca gcc ttc atc tgc ttt ttg gtc ttc att ctc aat gct 680 Phe Tyr Leu Thr Ala Phe Ile Cys Phe Leu Val Phe Ile Leu Asn Ala 200 205 210 ggt ctc gtt tgg ttc ttt cca tgg agg gaa gca aaa ccg ggc agt aca 728 Gly Leu Val Trp Phe Phe Pro Trp Arg Glu Ala Lys Pro Gly Ser Thr 215 220 225 gag aag ggc ctg cca ttg cga aag acc cat gtg ctg ttg gga agg agc 776 Glu Lys Gly Leu Pro Leu Arg Lys Thr His Val Leu Leu Gly Arg Ser 230 235 240 cat gac aca gtg cag gag gca gcc acc agc cgc aga gcc agg gcc agc 824 His Asp Thr Val Gln Glu Ala Ala Thr Ser Arg Arg Ala Arg Ala Ser 245 250 255 260 aag aag act gcc cag ccc tgg gtc gaa gta gtg ttg gcc ttg cgg aac 872 Lys Lys Thr Ala Gln Pro Trp Val Glu Val Val Leu Ala Leu Arg Asn 265 270 275 atg agg aac ctg ctg ttt tcc gaa atg tgg gac ata ttt ctg gtg cgc 920 Met Arg Asn Leu Leu Phe Ser Glu Met Trp Asp Ile Phe Leu Val Arg 280 285 290 ttg ctg atg gcc atg gca gtc atg ctg tac tac agt aac ttt gtc ctg 968 Leu Leu Met Ala Met Ala Val Met Leu Tyr Tyr Ser Asn Phe Val Leu 295 300 305 gcc ctg gag gag cgc ttt ggg gtg cgg ccc aag gtg aca ggc tac ctc 1016 Ala Leu Glu Glu Arg Phe Gly Val Arg Pro Lys Val Thr Gly Tyr Leu 310 315 320 atc agt tac agc agc atg ctg ggg gcc gtg gcc ggc ctt gcc ctg ggg 1064 Ile Ser Tyr Ser Ser Met Leu Gly Ala Val Ala Gly Leu Ala Leu Gly 325 330 335 340 cca atc cta cgg ctg tac aag cac aac tcg cag gca ctg ctg ctg cat 1112 Pro Ile Leu Arg Leu Tyr Lys His Asn Ser Gln Ala Leu Leu Leu His 345 350 355 tcc agc ata ctc acc tgc aca ctg ctg ctg ctc tac tcc ttg gcc ccc 1160 Ser Ser Ile Leu Thr Cys Thr Leu Leu Leu Leu Tyr Ser Leu Ala Pro 360 365 370 acc atg ggt gca gtt gtc ctc tcc tcc act ctc ctg tcc ttc tcc act 1208 Thr Met Gly Ala Val Val Leu Ser Ser Thr Leu Leu Ser Phe Ser Thr 375 380 385 gcc att ggc agg acg tgc atc acg gac ctc cag ctg act gtg ggc ggg 1256 Ala Ile Gly Arg Thr Cys Ile Thr Asp Leu Gln Leu Thr Val Gly Gly 390 395 400 gcc cag gcc agc ggc acc ctt att ggc gtg ggg cag tct gtg act gca 1304 Ala Gln Ala Ser Gly Thr Leu Ile Gly Val Gly Gln Ser Val Thr Ala 405 410 415 420 gtg ggc cgc atc atc gcc cct ctc ctc tcg ggg gtt gcc cag gag gtc 1352 Val Gly Arg Ile Ile Ala Pro Leu Leu Ser Gly Val Ala Gln Glu Val 425 430 435 agc cct tgc ggc ccc ccc agc ctg ggt gct gtg tta gcc tta gtg gcc 1400 Ser Pro Cys Gly Pro Pro Ser Leu Gly Ala Val Leu Ala Leu Val Ala 440 445 450 att ttc ata atg tct cta aac aag cga cac tct agt ggt gat ggg aat 1448 Ile Phe Ile Met Ser Leu Asn Lys Arg His Ser Ser Gly Asp Gly Asn 455 460 465 agt aaa tta aaa agt gag tagatggatt tggacaacat aaagcaacaa 1496 Ser Lys Leu Lys Ser Glu 470 aatttgagat ggttgaatga gggccggagg ccatgatgaa aagggcactt tggaaagggt 1556 tggggtggaa gggaaatatt tccgggtggg tgtgagctgt tgggcttcca ggtcagctct 1616 tggccatgca gccatgcctg caggatgatc agaagtcacg gcacctcatg ggaaggttaa 1676 gactggagca aagcttttcc aaggtgagca tattcagcgt ttacctggaa gtctcttctt 1736 cccacctggg ctaatcaggt tacaattttc aagggtaaac aaactaccag ctacaggata 1796 gggaagtggt ggtggaataa aagaacatga tacctggagg aagggaagaa accacaagca 1856 ttttcctact gaaaaatagg gtgacatgtc agtcaaattc tgatcaactg gaacttgagt 1916 ttccagttaa attccataca ctaggaggga gttttctatc aaaatcctgc agattgaaga 1976 agctggttta ttagaaccag cctgtcgctt ttcaaagctg gttaaaaata agatactgac 2036 ctcaccccta gagatgattc agtgggcctg ggtggggcca agaaatccgt ggtgttttgt 2096 aagcactgct ggcgatttct catggcagta aagaccacac tgagactgca ctgattttga 2156 ttaaagtaca taggcttggc tgtttttaca cagctaacta aatttggact cttaaaattg 2216 tgtttgtaat cacagtgtgt tacacctttc ccagctctca gcagttgtac tgcatgatgg 2276 agcagcgggc ccctgggacc tgttccctgt gctccctgcc tctgagagcc cagcttgctc 2336 tgaagttgga ctaaaccact tagatgctgg ggttgccaca gcctgctcct ggaagcctgc 2396 attccagtca ggttgcatcc ttctggtgct gacagaaccc agtggtgaag ccaaagcaca 2456 ggaatgcttt aaaaatgaac agtttatgca gaataagggt caggagtcat gccagaccag 2516 aacttgatgc tactgcgtct tgtgttaaga atcatttcct ggccaggctc ggtggctcag 2576 gcctgtaatc ccagcacttt gggaggctga ggcaggtgaa tcacttggtc aggagatgga 2636 gaccatcctg gctaacatgg tgaaaccccg tctctactaa aaatac 2682 <210> 310 <211> 474 <212> PRT <213> Homo sapiens <400> 310 Met Glu Leu Gly Gly His Trp Asp Met Asn Ser Ala Pro Arg Leu Val 1 5 10 15 Ser Glu Thr Ala Glu Arg Lys Gln Glu Gln Lys Thr Gly Thr Glu Ala 20 25 30 Glu Ala Ala Asp Ser Gly Ala Val Gly Ala Arg Arg Phe Leu Leu Cys 35 40 45 Leu Tyr Leu Val Gly Phe Leu Asp Leu Phe Gly Val Ser Met Val Val 50 55 60 Pro Leu Leu Ser Leu His Val Lys Ser Leu Gly Ala Ser Pro Thr Val 65 70 75 80 Ala Gly Ile Val Gly Ser Ser Tyr Gly Ile Leu Gln Leu Phe Ser Ser 85 90 95 Thr Leu Val Gly Cys Trp Ser Asp Val Val Gly Arg Arg Ser Ser Leu 100 105 110 Leu Ala Cys Ile Leu Leu Ser Ala Leu Gly Tyr Leu Leu Leu Gly Ala 115 120 125 Ala Thr Asn Val Phe Leu Phe Val Leu Ala Arg Val Pro Ala Gly Ile 130 135 140 Phe Lys His Thr Leu Ser Ile Ser Arg Ala Leu Leu Ser Asp Val Val 145 150 155 160 Pro Glu Lys Glu Arg Pro Leu Val Ile Gly His Phe Asn Thr Ala Ser 165 170 175 Gly Val Gly Phe Ile Leu Gly Pro Val Val Gly Gly Tyr Pro Thr Glu 180 185 190 Leu Glu Asp Gly Phe Tyr Leu Thr Ala Phe Ile Cys Phe Leu Val Phe 195 200 205 Ile Leu Asn Ala Gly Leu Val Trp Phe Phe Pro Trp Arg Glu Ala Lys 210 215 220 Pro Gly Ser Thr Glu Lys Gly Leu Pro Leu Arg Lys Thr His Val Leu 225 230 235 240 Leu Gly Arg Ser His Asp Thr Val Gln Glu Ala Ala Thr Ser Arg Arg 245 250 255 Ala Arg Ala Ser Lys Lys Thr Ala Gln Pro Trp Val Glu Val Val Leu 260 265 270 Ala Leu Arg Asn Met Arg Asn Leu Leu Phe Ser Glu Met Trp Asp Ile 275 280 285 Phe Leu Val Arg Leu Leu Met Ala Met Ala Val Met Leu Tyr Tyr Ser 290 295 300 Asn Phe Val Leu Ala Leu Glu Glu Arg Phe Gly Val Arg Pro Lys Val 305 310 315 320 Thr Gly Tyr Leu Ile Ser Tyr Ser Ser Met Leu Gly Ala Val Ala Gly 325 330 335 Leu Ala Leu Gly Pro Ile Leu Arg Leu Tyr Lys His Asn Ser Gln Ala 340 345 350 Leu Leu Leu His Ser Ser Ile Leu Thr Cys Thr Leu Leu Leu Leu Tyr 355 360 365 Ser Leu Ala Pro Thr Met Gly Ala Val Val Leu Ser Ser Thr Leu Leu 370 375 380 Ser Phe Ser Thr Ala Ile Gly Arg Thr Cys Ile Thr Asp Leu Gln Leu 385 390 395 400 Thr Val Gly Gly Ala Gln Ala Ser Gly Thr Leu Ile Gly Val Gly Gln 405 410 415 Ser Val Thr Ala Val Gly Arg Ile Ile Ala Pro Leu Leu Ser Gly Val 420 425 430 Ala Gln Glu Val Ser Pro Cys Gly Pro Pro Ser Leu Gly Ala Val Leu 435 440 445 Ala Leu Val Ala Ile Phe Ile Met Ser Leu Asn Lys Arg His Ser Ser 450 455 460 Gly Asp Gly Asn Ser Lys Leu Lys Ser Glu 465 470 <210> 311 <211> 2405 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (59)..(2248) <400> 311 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnn 58 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 106 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1 5 10 15 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 154 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 20 25 30 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 202 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 35 40 45 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 250 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 50 55 60 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 298 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 65 70 75 80 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 346 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 85 90 95 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 394 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 100 105 110 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 442 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 115 120 125 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 490 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 130 135 140 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 538 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 145 150 155 160 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 586 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 165 170 175 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 634 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 180 185 190 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 682 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 195 200 205 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 730 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 210 215 220 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 778 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 225 230 235 240 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 826 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 245 250 255 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 874 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 260 265 270 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 922 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 275 280 285 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 970 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 290 295 300 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1018 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 305 310 315 320 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1066 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 325 330 335 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1114 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 340 345 350 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1162 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 355 360 365 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1210 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 370 375 380 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1258 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 385 390 395 400 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1306 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 405 410 415 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1354 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 420 425 430 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1402 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 435 440 445 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1450 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 450 455 460 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1498 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 465 470 475 480 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1546 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 485 490 495 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1594 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 500 505 510 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1642 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 515 520 525 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1690 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 530 535 540 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1738 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 545 550 555 560 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1786 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 565 570 575 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1834 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 580 585 590 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1882 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 595 600 605 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1930 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 610 615 620 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1978 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 625 630 635 640 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 2026 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 645 650 655 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 2074 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 660 665 670 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 2122 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 675 680 685 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 2170 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 690 695 700 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 2218 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 705 710 715 720 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnnnnnnnnn nnnnnnnnnn 2268 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 725 730 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2328 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2388 nnnnnnnnnn nnnnnnn 2405 <210> 312 <211> 730 <212> PRT <213> Homo sapiens <400> 312 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1 5 10 15 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 20 25 30 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 35 40 45 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 50 55 60 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 65 70 75 80 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 85 90 95 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 100 105 110 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 115 120 125 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 130 135 140 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 145 150 155 160 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 165 170 175 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 180 185 190 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 195 200 205 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 210 215 220 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 225 230 235 240 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 245 250 255 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 260 265 270 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 275 280 285 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 290 295 300 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 305 310 315 320 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 325 330 335 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 340 345 350 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 355 360 365 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 370 375 380 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 385 390 395 400 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 405 410 415 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 420 425 430 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 435 440 445 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 450 455 460 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 465 470 475 480 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 485 490 495 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 500 505 510 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 515 520 525 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 530 535 540 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 545 550 555 560 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 565 570 575 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 580 585 590 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 595 600 605 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 610 615 620 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 625 630 635 640 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 645 650 655 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 660 665 670 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 675 680 685 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 690 695 700 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 705 710 715 720 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 725 730 <210> 313 <211> 2568 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (382)..(1680) <400> 313 tccgatccca ttccatccgt tcctcgtctc ctcccggtct gacccgttgc ccggccgtgg 60 ttcgccacac caggcatcca aagctgaggt cgctcctacg gcctgggctc gccttcgctt 120 tagagatgtt tggcctcttc cctcccaaac agcccatctt caaaacctgg actcttggac 180 tggcacctgg ccacctttcc ctctaccaag actccacttc cgtcttaccc acttcttcct 240 cagattcttg gtaccccctg ggttggagac tgctcatttt cctcccaaat taatcccaga 300 ccccctaaaa tattgacaac cttgacaacc ccccaaccga ggagccagac tttgttttgg 360 actaacttcc atagccctgt c atg gag gca gtg tac ctg gta gtg aat ggg 411 Met Glu Ala Val Tyr Leu Val Val Asn Gly 1 5 10 ttg ggc ctg gtg ctg gac gtg ctg acc ttg gtg ttg gac ctc aac ttc 459 Leu Gly Leu Val Leu Asp Val Leu Thr Leu Val Leu Asp Leu Asn Phe 15 20 25 ctg ctg gtg tcc tcc ctc ctg gct tcc ctg gcc tgg ctc ctg gcc ttc 507 Leu Leu Val Ser Ser Leu Leu Ala Ser Leu Ala Trp Leu Leu Ala Phe 30 35 40 gtc tac aac ctg ccg cac acg gta ctg act agt ctt ctg cac ttg ggc 555 Val Tyr Asn Leu Pro His Thr Val Leu Thr Ser Leu Leu His Leu Gly 45 50 55 cgc gga gtc ttg ctt tca ttg ctg gcc ttg atc gaa gcc gtg gtc cgg 603 Arg Gly Val Leu Leu Ser Leu Leu Ala Leu Ile Glu Ala Val Val Arg 60 65 70 ttc aca tgt ggg ggc ttg cag gcc ttg tgt act ctg ctg tat agc tgc 651 Phe Thr Cys Gly Gly Leu Gln Ala Leu Cys Thr Leu Leu Tyr Ser Cys 75 80 85 90 tgc tct ggc cta gag agc cta aag ctc ctg ggg cac ctg gcc tct cat 699 Cys Ser Gly Leu Glu Ser Leu Lys Leu Leu Gly His Leu Ala Ser His 95 100 105 ggg gca ctg cgg agc agg gag ata ctg cac cgg ggc gtc ctc aat gtg 747 Gly Ala Leu Arg Ser Arg Glu Ile Leu His Arg Gly Val Leu Asn Val 110 115 120 gtc tcc agt ggc cat gct ttg ctg cgc cag gcc tgt gac atc tgt gcc 795 Val Ser Ser Gly His Ala Leu Leu Arg Gln Ala Cys Asp Ile Cys Ala 125 130 135 att gcc atg agc ctg gtg gct tat gtg atc aac agc ctg gtc aac atc 843 Ile Ala Met Ser Leu Val Ala Tyr Val Ile Asn Ser Leu Val Asn Ile 140 145 150 tgc ctc atc ggc act cag aac ctc ttt tcc ctg gtg ctg gcc ctg tgg 891 Cys Leu Ile Gly Thr Gln Asn Leu Phe Ser Leu Val Leu Ala Leu Trp 155 160 165 170 gat gca gtg acc ggg cct ctg tgg agg atg aca gac gta gtg gct gcc 939 Asp Ala Val Thr Gly Pro Leu Trp Arg Met Thr Asp Val Val Ala Ala 175 180 185 ttc cta gcc cac att tcc agc agt gct gtg gcc atg gcc atc ctc ctt 987 Phe Leu Ala His Ile Ser Ser Ser Ala Val Ala Met Ala Ile Leu Leu 190 195 200 tgg aca ccc tgc caa cta gcc ctg gag ctg ctg gcc tca gct gcc cgc 1035 Trp Thr Pro Cys Gln Leu Ala Leu Glu Leu Leu Ala Ser Ala Ala Arg 205 210 215 ctc ctg gcc agc ttt gtg ctt gtc aat ctc act ggc ttg gtg ttg cta 1083 Leu Leu Ala Ser Phe Val Leu Val Asn Leu Thr Gly Leu Val Leu Leu 220 225 230 gct tgt gtg ctg gca gtg acg gtg act gtg ttg cat ccg gac ttc acc 1131 Ala Cys Val Leu Ala Val Thr Val Thr Val Leu His Pro Asp Phe Thr 235 240 245 250 ctg agg ctg gct acc cag gca ctc agc cag ctc cat gcc cgg cca tcc 1179 Leu Arg Leu Ala Thr Gln Ala Leu Ser Gln Leu His Ala Arg Pro Ser 255 260 265 tac cac cgt ctt cga gag gat gtc atg cgg ctc tct cgc cta gca ctg 1227 Tyr His Arg Leu Arg Glu Asp Val Met Arg Leu Ser Arg Leu Ala Leu 270 275 280 ggc tca gag gcc tgg cgc cga gtc tgg agc cgc agt ctg cag ctg gcg 1275 Gly Ser Glu Ala Trp Arg Arg Val Trp Ser Arg Ser Leu Gln Leu Ala 285 290 295 agt tgg cca aac cgg gga ggg gca cct gga gct ccc cag ggt gac cct 1323 Ser Trp Pro Asn Arg Gly Gly Ala Pro Gly Ala Pro Gln Gly Asp Pro 300 305 310 atg agg gta ttc tca gtt agg acc cgg aga cag gac act ctt cct gaa 1371 Met Arg Val Phe Ser Val Arg Thr Arg Arg Gln Asp Thr Leu Pro Glu 315 320 325 330 gcg ggg cgc aga tca gag gca gaa gag gag gag gcc agg acc atc aga 1419 Ala Gly Arg Arg Ser Glu Ala Glu Glu Glu Glu Ala Arg Thr Ile Arg 335 340 345 gtg aca cct gtc agg ggc cga gag agg ctc aat gag gag gag cct cca 1467 Val Thr Pro Val Arg Gly Arg Glu Arg Leu Asn Glu Glu Glu Pro Pro 350 355 360 ggt ggg caa gac cct tgg aaa ttg ctg aag gag caa gag gag cgg aag 1515 Gly Gly Gln Asp Pro Trp Lys Leu Leu Lys Glu Gln Glu Glu Arg Lys 365 370 375 aag tgt gtc atc tgc cag gac cag agc aag aca gtg ttg ctc ctg ccc 1563 Lys Cys Val Ile Cys Gln Asp Gln Ser Lys Thr Val Leu Leu Leu Pro 380 385 390 tgc cgg cat ctg tgc ctg tgc cag gcc tgc act gaa atc ctg atg cgc 1611 Cys Arg His Leu Cys Leu Cys Gln Ala Cys Thr Glu Ile Leu Met Arg 395 400 405 410 cac ccc gtc tac cac cgc aat tgc ccg ctc tgc cgc cgg ggc atc ctg 1659 His Pro Val Tyr His Arg Asn Cys Pro Leu Cys Arg Arg Gly Ile Leu 415 420 425 cag acc ctc aat gtc tac ctc tgaagcctcc ttccctgcct gcccacccct 1710 Gln Thr Leu Asn Val Tyr Leu 430 ccatgctcca cgcaggcact cacgctagga cagcattaac acctcatctc cgggtcctgg 1770 tctgaatccc ctcctacccc tgtggccatc ctgccataca tccaggacat tgagttggaa 1830 gactatgatc tgggtggggg caggataaca tggcttctct ttacccagtg ggtcccttcg 1890 atgctgaggg tggtgagtat gtcactatgc aagggccctg agactatttg ctgtgggctc 1950 tcctccagcc tgcccagggc ccacccagat gcctctgggg ttacccctgt ctgcttctgg 2010 tttttctgtt ggagatctat aggtcctttt cctgcctcct tcacatttcc tccccagctt 2070 ttgcggccac aacacatcag tgtcatttgg gtgttttggc aactcagggg ccttcggatg 2130 atcttaaacc tttgtgttca gccagagccc ctgtgccctg gtaggcgttg gggttagtat 2190 ctctcgggtg ccctcagagc cacctctgcc tgtgatcgtc tgatgaggct ccctcccaac 2250 ctgatccaaa agccagtctc aggagtttac ccctgggatg ggggatgcat ctgcacctga 2310 ctttggggcc acgtgccctg tggcacccca gctcactggg agtctcagga gggataaccg 2370 gatttctgct ctttcccctg tcactcccac atcacacaga aaaatggcat tcctctctgt 2430 ctctccctgg catggagagg gcagactgtg cacatttcac tagggttcaa atacagaagg 2490 gcccagggcc caggggcttg cagcttcgtg aggggtctcc ggcccagttt ccaatgaata 2550 aagttctctt gacagctc 2568 <210> 314 <211> 433 <212> PRT <213> Homo sapiens <400> 314 Met Glu Ala Val Tyr Leu Val Val Asn Gly Leu Gly Leu Val Leu Asp 1 5 10 15 Val Leu Thr Leu Val Leu Asp Leu Asn Phe Leu Leu Val Ser Ser Leu 20 25 30 Leu Ala Ser Leu Ala Trp Leu Leu Ala Phe Val Tyr Asn Leu Pro His 35 40 45 Thr Val Leu Thr Ser Leu Leu His Leu Gly Arg Gly Val Leu Leu Ser 50 55 60 Leu Leu Ala Leu Ile Glu Ala Val Val Arg Phe Thr Cys Gly Gly Leu 65 70 75 80 Gln Ala Leu Cys Thr Leu Leu Tyr Ser Cys Cys Ser Gly Leu Glu Ser 85 90 95 Leu Lys Leu Leu Gly His Leu Ala Ser His Gly Ala Leu Arg Ser Arg 100 105 110 Glu Ile Leu His Arg Gly Val Leu Asn Val Val Ser Ser Gly His Ala 115 120 125 Leu Leu Arg Gln Ala Cys Asp Ile Cys Ala Ile Ala Met Ser Leu Val 130 135 140 Ala Tyr Val Ile Asn Ser Leu Val Asn Ile Cys Leu Ile Gly Thr Gln 145 150 155 160 Asn Leu Phe Ser Leu Val Leu Ala Leu Trp Asp Ala Val Thr Gly Pro 165 170 175 Leu Trp Arg Met Thr Asp Val Val Ala Ala Phe Leu Ala His Ile Ser 180 185 190 Ser Ser Ala Val Ala Met Ala Ile Leu Leu Trp Thr Pro Cys Gln Leu 195 200 205 Ala Leu Glu Leu Leu Ala Ser Ala Ala Arg Leu Leu Ala Ser Phe Val 210 215 220 Leu Val Asn Leu Thr Gly Leu Val Leu Leu Ala Cys Val Leu Ala Val 225 230 235 240 Thr Val Thr Val Leu His Pro Asp Phe Thr Leu Arg Leu Ala Thr Gln 245 250 255 Ala Leu Ser Gln Leu His Ala Arg Pro Ser Tyr His Arg Leu Arg Glu 260 265 270 Asp Val Met Arg Leu Ser Arg Leu Ala Leu Gly Ser Glu Ala Trp Arg 275 280 285 Arg Val Trp Ser Arg Ser Leu Gln Leu Ala Ser Trp Pro Asn Arg Gly 290 295 300 Gly Ala Pro Gly Ala Pro Gln Gly Asp Pro Met Arg Val Phe Ser Val 305 310 315 320 Arg Thr Arg Arg Gln Asp Thr Leu Pro Glu Ala Gly Arg Arg Ser Glu 325 330 335 Ala Glu Glu Glu Glu Ala Arg Thr Ile Arg Val Thr Pro Val Arg Gly 340 345 350 Arg Glu Arg Leu Asn Glu Glu Glu Pro Pro Gly Gly Gln Asp Pro Trp 355 360 365 Lys Leu Leu Lys Glu Gln Glu Glu Arg Lys Lys Cys Val Ile Cys Gln 370 375 380 Asp Gln Ser Lys Thr Val Leu Leu Leu Pro Cys Arg His Leu Cys Leu 385 390 395 400 Cys Gln Ala Cys Thr Glu Ile Leu Met Arg His Pro Val Tyr His Arg 405 410 415 Asn Cys Pro Leu Cys Arg Arg Gly Ile Leu Gln Thr Leu Asn Val Tyr 420 425 430 Leu <210> 315 <211> 3624 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (16)..(1410) <400> 315 aagattttcg gcccc atg gcc agc gtc ggg aac atg gat gag aaa tcc aac 51 Met Ala Ser Val Gly Asn Met Asp Glu Lys Ser Asn 1 5 10 aag ctg ctg cta gct ttg gtg atg ctc ttc cta ttt gcc gtg atc gtc 99 Lys Leu Leu Leu Ala Leu Val Met Leu Phe Leu Phe Ala Val Ile Val 15 20 25 ctc caa tac gtg tgc ccc ggc aca gaa tgc cag ctc ctc cgc ctg cag 147 Leu Gln Tyr Val Cys Pro Gly Thr Glu Cys Gln Leu Leu Arg Leu Gln 30 35 40 gcg ttc agc tcc ccg gtg ccg gac ccg tac cgc tcg gag gat gag agc 195 Ala Phe Ser Ser Pro Val Pro Asp Pro Tyr Arg Ser Glu Asp Glu Ser 45 50 55 60 tcc gcc agg ttc gtg ccc cgc tac aat ttc acc cgc ggc gac ctc ctg 243 Ser Ala Arg Phe Val Pro Arg Tyr Asn Phe Thr Arg Gly Asp Leu Leu 65 70 75 cgc aag gta gac ttc gac atc aag ggc gat gac ctg atc gtg ttc ctg 291 Arg Lys Val Asp Phe Asp Ile Lys Gly Asp Asp Leu Ile Val Phe Leu 80 85 90 cac atc cag aag acc ggg ggc acc act ttc ggc cgc cac ttg gtg cgt 339 His Ile Gln Lys Thr Gly Gly Thr Thr Phe Gly Arg His Leu Val Arg 95 100 105 aac atc cag ctg gag cag ccg tgc gag tgc cgc gtg ggt cag aag aaa 387 Asn Ile Gln Leu Glu Gln Pro Cys Glu Cys Arg Val Gly Gln Lys Lys 110 115 120 tgc act tgc cac cgg ccg ggt aag cgg gaa acc tgg ctc ttc tcc agg 435 Cys Thr Cys His Arg Pro Gly Lys Arg Glu Thr Trp Leu Phe Ser Arg 125 130 135 140 ttc tcc acg ggc tgg agc tgc ggg ttg cac gcc gac tgg acc gag ctc 483 Phe Ser Thr Gly Trp Ser Cys Gly Leu His Ala Asp Trp Thr Glu Leu 145 150 155 acc agc tgt gtg ccc tcc gtg gtg gac ggc aag cgc gac gcc agg ctg 531 Thr Ser Cys Val Pro Ser Val Val Asp Gly Lys Arg Asp Ala Arg Leu 160 165 170 aga ccg tcc agg aac ttc cac tac atc acc atc ctc cga gac cca gtg 579 Arg Pro Ser Arg Asn Phe His Tyr Ile Thr Ile Leu Arg Asp Pro Val 175 180 185 tcc cgg tac ttg agt gag tgg agg cat gtc cag aga ggg gca aca tgg 627 Ser Arg Tyr Leu Ser Glu Trp Arg His Val Gln Arg Gly Ala Thr Trp 190 195 200 aaa gca tcc ctg cat gtc tgc gat gga agg cct cca acc tcc gaa gag 675 Lys Ala Ser Leu His Val Cys Asp Gly Arg Pro Pro Thr Ser Glu Glu 205 210 215 220 ctg ccc agc tgc tac act ggc gat gac tgg tct ggc tgc ccc ctc aaa 723 Leu Pro Ser Cys Tyr Thr Gly Asp Asp Trp Ser Gly Cys Pro Leu Lys 225 230 235 gag ttt atg gac tgt ccc tac aat cta gcc aac aac cgc cag gtg cgc 771 Glu Phe Met Asp Cys Pro Tyr Asn Leu Ala Asn Asn Arg Gln Val Arg 240 245 250 atg ctc tcc gac ctg acc ctg gta ggc tgc tac aac ctc tct gtc atg 819 Met Leu Ser Asp Leu Thr Leu Val Gly Cys Tyr Asn Leu Ser Val Met 255 260 265 cct gaa aag caa aga aac aag gtc ctt ctg gaa agt gcc aag tca aat 867 Pro Glu Lys Gln Arg Asn Lys Val Leu Leu Glu Ser Ala Lys Ser Asn 270 275 280 ctg agg cac atg gcg ttc ttc ggc ctc act gag ttt cag cgg aag acc 915 Leu Arg His Met Ala Phe Phe Gly Leu Thr Glu Phe Gln Arg Lys Thr 285 290 295 300 caa tat ctg ttt gag aaa acc ttc aac atg aac ttt att tcg cca ttt 963 Gln Tyr Leu Phe Glu Lys Thr Phe Asn Met Asn Phe Ile Ser Pro Phe 305 310 315 acc cag tat aat acc act agg gcc tct agt gta gag atc aat gag gaa 1011 Thr Gln Tyr Asn Thr Thr Arg Ala Ser Ser Val Glu Ile Asn Glu Glu 320 325 330 att caa aag cgt att gag gga ctg aat ttt ctg gat atg gag ttg tac 1059 Ile Gln Lys Arg Ile Glu Gly Leu Asn Phe Leu Asp Met Glu Leu Tyr 335 340 345 agc tat gcc aaa gac ctt ttt ttg cag agg tat cag ttt atg agg cag 1107 Ser Tyr Ala Lys Asp Leu Phe Leu Gln Arg Tyr Gln Phe Met Arg Gln 350 355 360 aaa gag cat cag gag gcc agg cga aag cgt cag gaa caa cgc aaa ttt 1155 Lys Glu His Gln Glu Ala Arg Arg Lys Arg Gln Glu Gln Arg Lys Phe 365 370 375 380 ctg aag gga agg ctc ctt cag acc cat ttc cag agc cag ggt cag ggc 1203 Leu Lys Gly Arg Leu Leu Gln Thr His Phe Gln Ser Gln Gly Gln Gly 385 390 395 cag agc cag aat ccg aat cag aat cag agt cag aac cca aat ccg aat 1251 Gln Ser Gln Asn Pro Asn Gln Asn Gln Ser Gln Asn Pro Asn Pro Asn 400 405 410 gcc aat cag aac ctg act cag aat ctg atg cag aat ctg act cag agt 1299 Ala Asn Gln Asn Leu Thr Gln Asn Leu Met Gln Asn Leu Thr Gln Ser 415 420 425 ttg agc cag aag gag aac cgg gaa agc ccg aag cgg aac tca ggc aag 1347 Leu Ser Gln Lys Glu Asn Arg Glu Ser Pro Lys Arg Asn Ser Gly Lys 430 435 440 ggg cag aat gat aac acc agc aat ggc act aac gac tac ata ggc agt 1395 Gly Gln Asn Asp Asn Thr Ser Asn Gly Thr Asn Asp Tyr Ile Gly Ser 445 450 455 460 gta gag aaa tgg cgt taaatggctc aaaaaggcct gtacatactt ctcccaaagc 1450 Val Glu Lys Trp Arg 465 gccactgaaa agatggcata gcttaaaaga tggaagtgtc caaacacatc ctgcttcctt 1510 cattggggaa gttttaaaaa aaagtttaga tgttgccttt acagttgcct ttcaattcag 1570 tgttatactg tgtgtaggta aaacaaatct caatatggaa ttaaattgtc tttttggggt 1630 tggactaaat atgaaatccg aaagccaaac cagactcacc agaaattgct gtttagatat 1690 tttaagaagt tcttaaatta gttatggaga caaagtgaaa acataaaatg tgaccattta 1750 acttatggct aagaaatgga ctttaaatta ttcatgatac actgttaaaa cccaatcttg 1810 gaatcaaata ttttttccag gggtgagaat aagtataaac ataaagcaac taaaatgaaa 1870 cataaaacct tttattttct tctgatttta acaaggaatc tatttaaata gaataacaac 1930 tgatggtgaa tcttaccgag ctgtagaaaa taaaaaattc ctctccaaac atgggtagtt 1990 ttatgtcaaa atattggctt ttcaagaaca ggactcatat cttgatattt aagagatgtt 2050 taaaatttta aactttttct accttctact gtttaaaggt tttacacagg gtgtatctca 2110 cattaaacaa aacacctttt tttcaaaatg aaataccaat gtaaagatct aatttccagg 2170 cgctttcagg gcactgtaat ttcaacaata ctggaatcat tttggcgctg cttctcattc 2230 attttaaggc ttctctgaat tgtgctcatt ccaaattaac ccatgtatag aatctttctt 2290 catcatctaa atggtgtgtt gctgaagtta ttgtggtata taatcctgga ttaaagtcag 2350 gactttcttt ctatagaatt attttatcaa tatttgtgta gtgaggtcct aatcaagaaa 2410 cttgaacagg ataatgtgtc taaaaatatt gctgaagtta ttcttgatca gatagaattt 2470 aacctaaaat gtgaactctt acttactttt tgtacatctc tattgtaatg tttccagttg 2530 ggccaactat ttctagccct ttagttcttt ttcatgttga cagatttgta gacaattaca 2590 aaagccaaaa aaggataaaa taagcattag gaaggctagc cagttattca atagcacctt 2650 gataatgtgg gcaaaccctt ctacaaagtt tttgttttga aaagagcaaa agtaaaaagt 2710 gttctgtagt gaggttacat atcaggaaca tatgagttga gcagagtaat ttggtagtgt 2770 aagtcgatgc aaaaatactt ctatggtacc tattacaagc tgaccaagat aaaaagaagt 2830 atgtaaccca ctgtgctgtc aagcatcatg attccgggca gttttcattt tactgtggat 2890 tttgctatac ttatgcaagg acttacacta acctcctggc tgtaaatcaa acaaggtgac 2950 tgaaagtggc atttatgttt tcacaaggga catgcttaga agtgtgacca taaagtcaca 3010 tcttgtacaa tctgctcatg tgtttcatct gtagtaatat agccacaaac tggacaagaa 3070 gctgggtatt tgggtttaaa atagattttc ttgactctga gcttgtatca gtatttctag 3130 cttttgtttt gtctgacagt attgcagtct tgaaaatcct gagagctaaa aaactgaaag 3190 gaatttttcc acaccttgaa gtcacagtgt tttagagtaa aactattttg tgtacaattg 3250 tgtttttaaa atagttagta gatcactatg gtatttcaat tttctttagt tttaattgaa 3310 aatgtttgct tttaaaactg ataggtattg ttggaaagca ggatgaagcc tgagccagtg 3370 gaaaagcttg ttacagaaaa aacattttgt gttattgctg tggtgtgcat gatttgcaaa 3430 gattaagtgc attttctctg tctatactga ttattgtata tagaggatgt tataaatata 3490 catatacatt tttgccatta tgtaaatccc atgatttcaa ctgtaaacat ctgtccattg 3550 gtgtagcttt acaaaccatt cactgatttt gtgtaattta acaatagata tgaaataaag 3610 tttaaattac aggc 3624 <210> 316 <211> 465 <212> PRT <213> Homo sapiens <400> 316 Met Ala Ser Val Gly Asn Met Asp Glu Lys Ser Asn Lys Leu Leu Leu 1 5 10 15 Ala Leu Val Met Leu Phe Leu Phe Ala Val Ile Val Leu Gln Tyr Val 20 25 30 Cys Pro Gly Thr Glu Cys Gln Leu Leu Arg Leu Gln Ala Phe Ser Ser 35 40 45 Pro Val Pro Asp Pro Tyr Arg Ser Glu Asp Glu Ser Ser Ala Arg Phe 50 55 60 Val Pro Arg Tyr Asn Phe Thr Arg Gly Asp Leu Leu Arg Lys Val Asp 65 70 75 80 Phe Asp Ile Lys Gly Asp Asp Leu Ile Val Phe Leu His Ile Gln Lys 85 90 95 Thr Gly Gly Thr Thr Phe Gly Arg His Leu Val Arg Asn Ile Gln Leu 100 105 110 Glu Gln Pro Cys Glu Cys Arg Val Gly Gln Lys Lys Cys Thr Cys His 115 120 125 Arg Pro Gly Lys Arg Glu Thr Trp Leu Phe Ser Arg Phe Ser Thr Gly 130 135 140 Trp Ser Cys Gly Leu His Ala Asp Trp Thr Glu Leu Thr Ser Cys Val 145 150 155 160 Pro Ser Val Val Asp Gly Lys Arg Asp Ala Arg Leu Arg Pro Ser Arg 165 170 175 Asn Phe His Tyr Ile Thr Ile Leu Arg Asp Pro Val Ser Arg Tyr Leu 180 185 190 Ser Glu Trp Arg His Val Gln Arg Gly Ala Thr Trp Lys Ala Ser Leu 195 200 205 His Val Cys Asp Gly Arg Pro Pro Thr Ser Glu Glu Leu Pro Ser Cys 210 215 220 Tyr Thr Gly Asp Asp Trp Ser Gly Cys Pro Leu Lys Glu Phe Met Asp 225 230 235 240 Cys Pro Tyr Asn Leu Ala Asn Asn Arg Gln Val Arg Met Leu Ser Asp 245 250 255 Leu Thr Leu Val Gly Cys Tyr Asn Leu Ser Val Met Pro Glu Lys Gln 260 265 270 Arg Asn Lys Val Leu Leu Glu Ser Ala Lys Ser Asn Leu Arg His Met 275 280 285 Ala Phe Phe Gly Leu Thr Glu Phe Gln Arg Lys Thr Gln Tyr Leu Phe 290 295 300 Glu Lys Thr Phe Asn Met Asn Phe Ile Ser Pro Phe Thr Gln Tyr Asn 305 310 315 320 Thr Thr Arg Ala Ser Ser Val Glu Ile Asn Glu Glu Ile Gln Lys Arg 325 330 335 Ile Glu Gly Leu Asn Phe Leu Asp Met Glu Leu Tyr Ser Tyr Ala Lys 340 345 350 Asp Leu Phe Leu Gln Arg Tyr Gln Phe Met Arg Gln Lys Glu His Gln 355 360 365 Glu Ala Arg Arg Lys Arg Gln Glu Gln Arg Lys Phe Leu Lys Gly Arg 370 375 380 Leu Leu Gln Thr His Phe Gln Ser Gln Gly Gln Gly Gln Ser Gln Asn 385 390 395 400 Pro Asn Gln Asn Gln Ser Gln Asn Pro Asn Pro Asn Ala Asn Gln Asn 405 410 415 Leu Thr Gln Asn Leu Met Gln Asn Leu Thr Gln Ser Leu Ser Gln Lys 420 425 430 Glu Asn Arg Glu Ser Pro Lys Arg Asn Ser Gly Lys Gly Gln Asn Asp 435 440 445 Asn Thr Ser Asn Gly Thr Asn Asp Tyr Ile Gly Ser Val Glu Lys Trp 450 455 460 Arg 465 <210> 317 <211> 2530 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (138)..(845) <400> 317 agtctgtcgg agtctgtcct cggagcaggc ggagtaaagg gacttgagcg agccagttgc 60 cggattattc tatttcccct ccctctctcc cgccccgtat ctcttttcac ccttctccca 120 ccctcgctcg cgtagcc atg gcg gag ccg tcg gcg gcc act cag tcc cat 170 Met Ala Glu Pro Ser Ala Ala Thr Gln Ser His 1 5 10 tcc atc tcc tcg tcg tcc ttc gga gcc gag ccg tcc gcg ccc ggc ggc 218 Ser Ile Ser Ser Ser Ser Phe Gly Ala Glu Pro Ser Ala Pro Gly Gly 15 20 25 ggc ggg agc cca gga gcc tgc ccc gcc ctg ggg acg aag agc tgc agc 266 Gly Gly Ser Pro Gly Ala Cys Pro Ala Leu Gly Thr Lys Ser Cys Ser 30 35 40 tcc tcc tgt gcg gtg cac gat ctg att ttc tgg aga gat gtg aag aag 314 Ser Ser Cys Ala Val His Asp Leu Ile Phe Trp Arg Asp Val Lys Lys 45 50 55 act ggg ttt gtc ttt ggc acc acg ctg atc atg ctg ctt tcc ctg gca 362 Thr Gly Phe Val Phe Gly Thr Thr Leu Ile Met Leu Leu Ser Leu Ala 60 65 70 75 gct ttc agt gtc atc agt gtg gtt tct tac ctc atc ctg gct ctt ctc 410 Ala Phe Ser Val Ile Ser Val Val Ser Tyr Leu Ile Leu Ala Leu Leu 80 85 90 tct gtc acc atc agc ttc agg atc tac aag tcc gtc atc caa gct gta 458 Ser Val Thr Ile Ser Phe Arg Ile Tyr Lys Ser Val Ile Gln Ala Val 95 100 105 cag aag tca gaa gaa ggc cat cca ttc aaa gcc tac ctg gac gta gac 506 Gln Lys Ser Glu Glu Gly His Pro Phe Lys Ala Tyr Leu Asp Val Asp 110 115 120 att act ctg tcc tca gaa gct ttc cat aat tac atg aat gct gcc atg 554 Ile Thr Leu Ser Ser Glu Ala Phe His Asn Tyr Met Asn Ala Ala Met 125 130 135 gtg cac atc aac agg gcc ctg aaa ctc att att cgt ctc ttt ctg gta 602 Val His Ile Asn Arg Ala Leu Lys Leu Ile Ile Arg Leu Phe Leu Val 140 145 150 155 gaa gat ctg gtt gac tcc ttg aag ctg gct gtc ttc atg tgg ctg atg 650 Glu Asp Leu Val Asp Ser Leu Lys Leu Ala Val Phe Met Trp Leu Met 160 165 170 acc tat gtt ggt gct gtt ttt aac gga atc acc ctt cta att ctt gct 698 Thr Tyr Val Gly Ala Val Phe Asn Gly Ile Thr Leu Leu Ile Leu Ala 175 180 185 gaa ctg ctc att ttc agt gtc ccg att gtc tat gag aag tac aag acc 746 Glu Leu Leu Ile Phe Ser Val Pro Ile Val Tyr Glu Lys Tyr Lys Thr 190 195 200 cag att gat cac tat gtt ggc atc gcc cga gat cag acc aag tca att 794 Gln Ile Asp His Tyr Val Gly Ile Ala Arg Asp Gln Thr Lys Ser Ile 205 210 215 gtt gaa aag atc caa gca aaa ctc cct gga atc gcc aaa aaa aag gca 842 Val Glu Lys Ile Gln Ala Lys Leu Pro Gly Ile Ala Lys Lys Lys Ala 220 225 230 235 gaa taagtacatg gaaaccagaa atgcaacagt tactaaaaca ccatttaata 895 Glu gttataacgt cgttacttgt actatgaagg aaaatactca gtgtcagctt gagcctgcat 955 tccaagcttt tttttaattt ggtgttttct cccatccttt ccctttaacc ctcagtatca 1015 agcacaaaaa ttgatggact gataaaagaa ctatcttaga actcagaaga agaaagaatc 1075 aaattcatag gataagtcaa taccttaatg gtggtagagc ctttacctgt agcttgaaag 1135 gggaaagatt ggaggtaaga gagaaaatga aagaacacct ctgggtcctt ctgtccagtt 1195 ttcagcacta gtcttactca gctatccatt atagttttgc ccttaagaag tcatgattaa 1255 cttatgaaaa aattatttgg ggacaggagt gtgatacctt ccttggtttt tttttgcagc 1315 cctcaaatcc tatcttcctg ccccacaatg tgagcagcta cccctgatac tccttttctt 1375 taatgattta actatcaact tgataaataa cttataggtg atagtgataa ttcctgattc 1435 caagaatgcc atctgataaa aaagaataga aatggaaagt gggactgaga gggagtcagc 1495 aggcatgctg cggtggcggt cactccctct gccactatcc ccagggaagg aaaggctccg 1555 ccatttggga aagtggtttc tacgtcactg gacaccggtt ctgagcatta gtttgagaac 1615 tcgttcccga atgtgctttc ctccctctcc cctgcccacc tcaagtttaa taaataaggt 1675 tgtacttttc ttactataaa ataaatgtct gtaactgctg tgcactgctg taaacttgtt 1735 agagaaaaaa ataacctgca tgtgggctcc tcagttattg agtttttgtg atcctatctc 1795 agtctggggg ggaacattct caagaggtga aatacagaaa gccttttttt cttgatcttt 1855 tcccgagatt caaatctccg attcccattt gtgggcaagt ttttttcttc accttcaata 1915 tgagaattca gcgaacttga aagaaaaatc atctgtgagt tccttcaggt tctcactcat 1975 agtcatgatc cttcagaggg aatatgcact ggcgagttta aagtaagggc tatgatattt 2035 gatggtccca aagtacggca gctgcaaaaa gtagtggaag gaaattgtct acgtgtcttg 2095 gaaaaattag ttaggaattt ggatgggtaa aaggtaccct tgccttactc catcttattt 2155 tcttagcccc ctttgagtgt tttaactggt ttcatgtcct agtaggaagt gcattctcca 2215 tcctcatcct ctgccctccc aggaagtcag tgattgtctt tttgggcttc ccctccaaag 2275 gaccttctgc agtggaagtg ccacatccag ttcttttctt ttgttgctgc tgtgtttaga 2335 taattgaaga gatctttgtg ccacacagga tttttttttt ttttaagaaa aacctataga 2395 tgaaaaatta ctaatgaaac tgtgtgtacg tgtctgtgcg tgcaacataa aaatacagta 2455 gcacctaagg agcttgaatc ttggttcctg taaaatttca aattgatgtg gtattaataa 2515 aaaaaaaaaa aacac 2530 <210> 318 <211> 236 <212> PRT <213> Homo sapiens <400> 318 Met Ala Glu Pro Ser Ala Ala Thr Gln Ser His Ser Ile Ser Ser Ser 1 5 10 15 Ser Phe Gly Ala Glu Pro Ser Ala Pro Gly Gly Gly Gly Ser Pro Gly 20 25 30 Ala Cys Pro Ala Leu Gly Thr Lys Ser Cys Ser Ser Ser Cys Ala Val 35 40 45 His Asp Leu Ile Phe Trp Arg Asp Val Lys Lys Thr Gly Phe Val Phe 50 55 60 Gly Thr Thr Leu Ile Met Leu Leu Ser Leu Ala Ala Phe Ser Val Ile 65 70 75 80 Ser Val Val Ser Tyr Leu Ile Leu Ala Leu Leu Ser Val Thr Ile Ser 85 90 95 Phe Arg Ile Tyr Lys Ser Val Ile Gln Ala Val Gln Lys Ser Glu Glu 100 105 110 Gly His Pro Phe Lys Ala Tyr Leu Asp Val Asp Ile Thr Leu Ser Ser 115 120 125 Glu Ala Phe His Asn Tyr Met Asn Ala Ala Met Val His Ile Asn Arg 130 135 140 Ala Leu Lys Leu Ile Ile Arg Leu Phe Leu Val Glu Asp Leu Val Asp 145 150 155 160 Ser Leu Lys Leu Ala Val Phe Met Trp Leu Met Thr Tyr Val Gly Ala 165 170 175 Val Phe Asn Gly Ile Thr Leu Leu Ile Leu Ala Glu Leu Leu Ile Phe 180 185 190 Ser Val Pro Ile Val Tyr Glu Lys Tyr Lys Thr Gln Ile Asp His Tyr 195 200 205 Val Gly Ile Ala Arg Asp Gln Thr Lys Ser Ile Val Glu Lys Ile Gln 210 215 220 Ala Lys Leu Pro Gly Ile Ala Lys Lys Lys Ala Glu 225 230 235 <210> 319 <211> 1873 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (20)..(1768) <400> 319 acgcgcccag acggccgcg atg gcg ctg ttg gcc ggc ggg ctc tcc aga ggg 52 Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly 1 5 10 ctg ggc tcc cac ccg gcc gcc gca ggc cgg gac gcg gtc gtc ttc gtg 100 Leu Gly Ser His Pro Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val 15 20 25 tgg ctt ctg ctt agc acc tgg tgc aca gct cct gcc agg gcc atc cag 148 Trp Leu Leu Leu Ser Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln 30 35 40 gtg acc gtg tcc aac ccc tac cac gtg gtg atc ctc ttc cag cct gtg 196 Val Thr Val Ser Asn Pro Tyr His Val Val Ile Leu Phe Gln Pro Val 45 50 55 acc ctg ccc tgt acc tac cag atg acc tcg acc ccc acg caa ccc atc 244 Thr Leu Pro Cys Thr Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile 60 65 70 75 gtc atc tgg aag tac aag tct ttc tgc cgg gac cgc atc gcc gat gcc 292 Val Ile Trp Lys Tyr Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala 80 85 90 ttc tcc ccg gcc agc gtc gac aac cag ctc aat gcc cag ctg gca gcc 340 Phe Ser Pro Ala Ser Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala 95 100 105 ggg aac cca ggc tac aac ccc tac gtt gag tgc cag gac agc gtg cgc 388 Gly Asn Pro Gly Tyr Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg 110 115 120 acc gtc agg gtc gtg gcc acc aag cag ggc aac gct gtg acc ctg gga 436 Thr Val Arg Val Val Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly 125 130 135 gat tac tac cag ggc cgg agg att acc atc acc gga aat gct gac ctg 484 Asp Tyr Tyr Gln Gly Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu 140 145 150 155 acc ttt gac cag acg gcg tgg ggg gac agt ggt gtg tat tac tgc tcc 532 Thr Phe Asp Gln Thr Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser 160 165 170 gtg gtc tca gcc cag gac ctc cag ggg aac aat gag gcc tac gca gag 580 Val Val Ser Ala Gln Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu 175 180 185 ctc atc gtc ctt gac tgg ctc ttc gtg gtt gtg gta tgc ctg gct gcc 628 Leu Ile Val Leu Asp Trp Leu Phe Val Val Val Val Cys Leu Ala Ala 190 195 200 ttc ctc atc ttc ctc ctc ctg ggc atc tgc tgg tgc cag tgc tgc ccg 676 Phe Leu Ile Phe Leu Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro 205 210 215 cac act tgc tgc tgc tac gtc agg tgc ccc tgc tgc cca gac aag tgc 724 His Thr Cys Cys Cys Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys 220 225 230 235 tgc tgc ccc gag gcc ctg tat gcc gcc ggc aaa gca gcc acc tca ggt 772 Cys Cys Pro Glu Ala Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly 240 245 250 gtt ccc agc att tat gcc ccc agc acc tat gcc cac ctg tct ccc gcc 820 Val Pro Ser Ile Tyr Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala 255 260 265 aag acc cca ccc cca cca gct atg att ccc atg ggc cct gcc tac aac 868 Lys Thr Pro Pro Pro Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn 270 275 280 ggg tac cct gga gga tac cct gga gac gtt gac agg aat agc tcg gct 916 Gly Tyr Pro Gly Gly Tyr Pro Gly Asp Val Asp Arg Asn Ser Ser Ala 285 290 295 ggt ggc caa ggc tcc tat gta ccc ctg ctt cgg gac acg gac agc agt 964 Gly Gly Gln Gly Ser Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser 300 305 310 315 gtg gcc tct gaa gtc cgc agt ggc tac agg att cag gcc agc cag cag 1012 Val Ala Ser Glu Val Arg Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln 320 325 330 gac gac tcc atg cgg gtc ctg tac tac atg gag aag gag ctg gcc aac 1060 Asp Asp Ser Met Arg Val Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn 335 340 345 ttc gac cct tct cga cct ggc ccc ccc agt ggc cgt gtg gag cgg gcc 1108 Phe Asp Pro Ser Arg Pro Gly Pro Pro Ser Gly Arg Val Glu Arg Ala 350 355 360 atg agt gaa gtc acc tcc ctc cac gag gac gac tgg cga tct cgg cct 1156 Met Ser Glu Val Thr Ser Leu His Glu Asp Asp Trp Arg Ser Arg Pro 365 370 375 tcc cgg ggc cct gcc ctc acc ccg atc cgg gat gag gag tgg ggt ggc 1204 Ser Arg Gly Pro Ala Leu Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly 380 385 390 395 cac tcc ccc cgg agt ccc agg gga tgg gac cag gag ccc gcc agg gag 1252 His Ser Pro Arg Ser Pro Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu 400 405 410 cag gca ggc ggg ggc tgg cgg gcc agg cgg ccc cgg gcc cgc tcc gtg 1300 Gln Ala Gly Gly Gly Trp Arg Ala Arg Arg Pro Arg Ala Arg Ser Val 415 420 425 gac gcc ctg gac gac ctc acc ccg ccg agc acc gcc gag tca ggg agc 1348 Asp Ala Leu Asp Asp Leu Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser 430 435 440 agg tct ccc acg agt aat ggt ggg agg aga agc cgg gcc tac atg ccc 1396 Arg Ser Pro Thr Ser Asn Gly Gly Arg Arg Ser Arg Ala Tyr Met Pro 445 450 455 ccg cgg agc cgc agc cgg gac gac ctc tat gac caa gac gac tcg agg 1444 Pro Arg Ser Arg Ser Arg Asp Asp Leu Tyr Asp Gln Asp Asp Ser Arg 460 465 470 475 gac ttc cca cgc tcc cgg gac ccc cac tac gac gac ttc agg tct cgg 1492 Asp Phe Pro Arg Ser Arg Asp Pro His Tyr Asp Asp Phe Arg Ser Arg 480 485 490 gag cgc cct cct gcc gac ccc agg tcc cac cac cac cgt acc cgg gac 1540 Glu Arg Pro Pro Ala Asp Pro Arg Ser His His His Arg Thr Arg Asp 495 500 505 cct cgg gac aac ggc tcc agg tcc ggg gac ctc ccc tat gat ggg cgg 1588 Pro Arg Asp Asn Gly Ser Arg Ser Gly Asp Leu Pro Tyr Asp Gly Arg 510 515 520 cta ctg gag gag gct gtg agg aag aag ggg tcg gag gag agg agg aga 1636 Leu Leu Glu Glu Ala Val Arg Lys Lys Gly Ser Glu Glu Arg Arg Arg 525 530 535 ccc cac aag gag gag gag gaa gag gcc tac tac ccg ccc gcg ccg ccc 1684 Pro His Lys Glu Glu Glu Glu Glu Ala Tyr Tyr Pro Pro Ala Pro Pro 540 545 550 555 ccg tac tcg gag acc gac tcg cag gcg tcc cga gag cgc agg ctc aag 1732 Pro Tyr Ser Glu Thr Asp Ser Gln Ala Ser Arg Glu Arg Arg Leu Lys 560 565 570 aag aac ttg gcc ctg agt cgg gaa agt tta gtc gtc tgatctgacg 1778 Lys Asn Leu Ala Leu Ser Arg Glu Ser Leu Val Val 575 580 ttttctacgt agcttttgta tttttttttt aatttgaagg aacactgatg aagccctgcc 1838 atacccctcc cgagtctaat aaaacgtata atcac 1873 <210> 320 <211> 583 <212> PRT <213> Homo sapiens <400> 320 Met Ala Leu Leu Ala Gly Gly Leu Ser Arg Gly Leu Gly Ser His Pro 1 5 10 15 Ala Ala Ala Gly Arg Asp Ala Val Val Phe Val Trp Leu Leu Leu Ser 20 25 30 Thr Trp Cys Thr Ala Pro Ala Arg Ala Ile Gln Val Thr Val Ser Asn 35 40 45 Pro Tyr His Val Val Ile Leu Phe Gln Pro Val Thr Leu Pro Cys Thr 50 55 60 Tyr Gln Met Thr Ser Thr Pro Thr Gln Pro Ile Val Ile Trp Lys Tyr 65 70 75 80 Lys Ser Phe Cys Arg Asp Arg Ile Ala Asp Ala Phe Ser Pro Ala Ser 85 90 95 Val Asp Asn Gln Leu Asn Ala Gln Leu Ala Ala Gly Asn Pro Gly Tyr 100 105 110 Asn Pro Tyr Val Glu Cys Gln Asp Ser Val Arg Thr Val Arg Val Val 115 120 125 Ala Thr Lys Gln Gly Asn Ala Val Thr Leu Gly Asp Tyr Tyr Gln Gly 130 135 140 Arg Arg Ile Thr Ile Thr Gly Asn Ala Asp Leu Thr Phe Asp Gln Thr 145 150 155 160 Ala Trp Gly Asp Ser Gly Val Tyr Tyr Cys Ser Val Val Ser Ala Gln 165 170 175 Asp Leu Gln Gly Asn Asn Glu Ala Tyr Ala Glu Leu Ile Val Leu Asp 180 185 190 Trp Leu Phe Val Val Val Val Cys Leu Ala Ala Phe Leu Ile Phe Leu 195 200 205 Leu Leu Gly Ile Cys Trp Cys Gln Cys Cys Pro His Thr Cys Cys Cys 210 215 220 Tyr Val Arg Cys Pro Cys Cys Pro Asp Lys Cys Cys Cys Pro Glu Ala 225 230 235 240 Leu Tyr Ala Ala Gly Lys Ala Ala Thr Ser Gly Val Pro Ser Ile Tyr 245 250 255 Ala Pro Ser Thr Tyr Ala His Leu Ser Pro Ala Lys Thr Pro Pro Pro 260 265 270 Pro Ala Met Ile Pro Met Gly Pro Ala Tyr Asn Gly Tyr Pro Gly Gly 275 280 285 Tyr Pro Gly Asp Val Asp Arg Asn Ser Ser Ala Gly Gly Gln Gly Ser 290 295 300 Tyr Val Pro Leu Leu Arg Asp Thr Asp Ser Ser Val Ala Ser Glu Val 305 310 315 320 Arg Ser Gly Tyr Arg Ile Gln Ala Ser Gln Gln Asp Asp Ser Met Arg 325 330 335 Val Leu Tyr Tyr Met Glu Lys Glu Leu Ala Asn Phe Asp Pro Ser Arg 340 345 350 Pro Gly Pro Pro Ser Gly Arg Val Glu Arg Ala Met Ser Glu Val Thr 355 360 365 Ser Leu His Glu Asp Asp Trp Arg Ser Arg Pro Ser Arg Gly Pro Ala 370 375 380 Leu Thr Pro Ile Arg Asp Glu Glu Trp Gly Gly His Ser Pro Arg Ser 385 390 395 400 Pro Arg Gly Trp Asp Gln Glu Pro Ala Arg Glu Gln Ala Gly Gly Gly 405 410 415 Trp Arg Ala Arg Arg Pro Arg Ala Arg Ser Val Asp Ala Leu Asp Asp 420 425 430 Leu Thr Pro Pro Ser Thr Ala Glu Ser Gly Ser Arg Ser Pro Thr Ser 435 440 445 Asn Gly Gly Arg Arg Ser Arg Ala Tyr Met Pro Pro Arg Ser Arg Ser 450 455 460 Arg Asp Asp Leu Tyr Asp Gln Asp Asp Ser Arg Asp Phe Pro Arg Ser 465 470 475 480 Arg Asp Pro His Tyr Asp Asp Phe Arg Ser Arg Glu Arg Pro Pro Ala 485 490 495 Asp Pro Arg Ser His His His Arg Thr Arg Asp Pro Arg Asp Asn Gly 500 505 510 Ser Arg Ser Gly Asp Leu Pro Tyr Asp Gly Arg Leu Leu Glu Glu Ala 515 520 525 Val Arg Lys Lys Gly Ser Glu Glu Arg Arg Arg Pro His Lys Glu Glu 530 535 540 Glu Glu Glu Ala Tyr Tyr Pro Pro Ala Pro Pro Pro Tyr Ser Glu Thr 545 550 555 560 Asp Ser Gln Ala Ser Arg Glu Arg Arg Leu Lys Lys Asn Leu Ala Leu 565 570 575 Ser Arg Glu Ser Leu Val Val 580 <210> 321 <211> 2153 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (244)..(1272) <400> 321 atgcgggttc tgcttccaaa gccatctctt ccagcaggag agggctctac tctgagctcc 60 tattttccaa ggctccgggc cgcgctcggc gctggcctgc tgccccggcg ggtccgccgg 120 ccggaggcgg gagtcacagg aagagccctc cacaaaagga ggcctcggcg gatcaggaca 180 gctgcaggtg ggtgtgcaga ctggtgagct gccagcaggg gcccagacgc gccaggcctg 240 gag atg gct gga aac tgc tcc tgg gag gcc cat ccc ggc aac agg aac 288 Met Ala Gly Asn Cys Ser Trp Glu Ala His Pro Gly Asn Arg Asn 1 5 10 15 agg atg tgc cct ggc ctg agc gag gcc ccg gaa ctc tac agc cgg ggc 336 Arg Met Cys Pro Gly Leu Ser Glu Ala Pro Glu Leu Tyr Ser Arg Gly 20 25 30 ttc ctg acc atc gag cag atc gcg atg ctg ccg cct ccg gcc gtc atg 384 Phe Leu Thr Ile Glu Gln Ile Ala Met Leu Pro Pro Pro Ala Val Met 35 40 45 aac tac atc ttc ctg ctc ctc tgc ctg tgt ggc ctg gtg ggc aac ggg 432 Asn Tyr Ile Phe Leu Leu Leu Cys Leu Cys Gly Leu Val Gly Asn Gly 50 55 60 ctg gtc ctc tgg ttt ttc ggc ttc tcc atc aag agg aac ccc ttc tcc 480 Leu Val Leu Trp Phe Phe Gly Phe Ser Ile Lys Arg Asn Pro Phe Ser 65 70 75 atc tac ttc ctg cac ctg gcc agc gcc gat gtg ggc tac ctc ttc agc 528 Ile Tyr Phe Leu His Leu Ala Ser Ala Asp Val Gly Tyr Leu Phe Ser 80 85 90 95 aag gcg gtg ttc tcc atc ctg aac acg ggg ggc ttc ctg ggc acg ttt 576 Lys Ala Val Phe Ser Ile Leu Asn Thr Gly Gly Phe Leu Gly Thr Phe 100 105 110 gcc gac tac atc cgc agc gtg tgc cgg gtc ctg ggg ctc tgc atg ttc 624 Ala Asp Tyr Ile Arg Ser Val Cys Arg Val Leu Gly Leu Cys Met Phe 115 120 125 ctt acc ggc gtg agc ctc ctg ccg gcc gtc agc gcc gag cgc tgc gcc 672 Leu Thr Gly Val Ser Leu Leu Pro Ala Val Ser Ala Glu Arg Cys Ala 130 135 140 tcg gtc atc ttc ccc gcc tgg tac tgg cgc cgg cgg ccc aag cgc ctg 720 Ser Val Ile Phe Pro Ala Trp Tyr Trp Arg Arg Arg Pro Lys Arg Leu 145 150 155 tcg gcc gtg gtg tgc gcc ctg ctg tgg gtc ctg tcc ctc ctg gtc acc 768 Ser Ala Val Val Cys Ala Leu Leu Trp Val Leu Ser Leu Leu Val Thr 160 165 170 175 tgc ctg cac aac tac ttc tgc gtg ttc ctg ggc cgc ggg gcc ccc ggc 816 Cys Leu His Asn Tyr Phe Cys Val Phe Leu Gly Arg Gly Ala Pro Gly 180 185 190 gcg gcc tgc agg cac atg gac atc ttc ctg ggc atc ctc ctg ttc ctg 864 Ala Ala Cys Arg His Met Asp Ile Phe Leu Gly Ile Leu Leu Phe Leu 195 200 205 ctc tgc tgc ccg ctc atg gtg ctg ccc tgc ctg gcc ctc atc ctg cac 912 Leu Cys Cys Pro Leu Met Val Leu Pro Cys Leu Ala Leu Ile Leu His 210 215 220 gtg gag tgc cgg gcc cga cgg cgc cag cgc tct gcc aag ctc aac cac 960 Val Glu Cys Arg Ala Arg Arg Arg Gln Arg Ser Ala Lys Leu Asn His 225 230 235 gtc atc ctg gcc atg gtc tcc gtc ttc ctg gtg tcc tcc atc tac tta 1008 Val Ile Leu Ala Met Val Ser Val Phe Leu Val Ser Ser Ile Tyr Leu 240 245 250 255 ggg atc gac tgg ttc ctc ttc tgg gtc ttc cag atc ccg gcc ccc ttc 1056 Gly Ile Asp Trp Phe Leu Phe Trp Val Phe Gln Ile Pro Ala Pro Phe 260 265 270 ccc gag tac gtc act gac ctg tgc atc tgc atc aac agc agc gcc aag 1104 Pro Glu Tyr Val Thr Asp Leu Cys Ile Cys Ile Asn Ser Ser Ala Lys 275 280 285 ccc atc gtc tac ttc ctg gcc ggg agg gac aag tcg cag cgg ctg tgg 1152 Pro Ile Val Tyr Phe Leu Ala Gly Arg Asp Lys Ser Gln Arg Leu Trp 290 295 300 gag ccg ctc agg gtg gtc ttc cag cgg gcc ctg cgg gac ggc gct gag 1200 Glu Pro Leu Arg Val Val Phe Gln Arg Ala Leu Arg Asp Gly Ala Glu 305 310 315 ctg ggg gag gcc ggg ggc agc acg ccc aac aca gtc acc atg gag atg 1248 Leu Gly Glu Ala Gly Gly Ser Thr Pro Asn Thr Val Thr Met Glu Met 320 325 330 335 cag tgt ccc ccg ggg aac gcc tcc tgagactcca gcgcctggag gaggcagggg 1302 Gln Cys Pro Pro Gly Asn Ala Ser 340 caggaagcgg cctccaagac ccttcgcctt gggacaggaa tgggcacctg cttctgagtc 1362 catacaggag aagaaagatc tgtttcctct cctcgggcct ccttctccct gggctgggga 1422 ctccaggggt ggctgggaga ctgggcagcc accagcaaac agacctgtgg cccctgcccg 1482 gctcccccac ccattctgct cccctagaga cctcttgtac agaagttgcc cccaggtggt 1542 ggggcccctc cttgccctag gctggttggt aaaagagagg aggtcaacac ccagcctagc 1602 cacctctgcc tcttgggtca gccctccttg actgtgtccc agccagcacc aggccagcag 1662 cctcatccct gccattcagg gctgttccag agattcgatc ctcttaaggc attatcagtg 1722 agcaaatgtg aaggaaatgg tgtctggaag aaagttctgg ttcacatgcc ttgtagctaa 1782 gtctttctgc aaacaacctc ccttcccccc gtcgagtcat ttggtgactt tgatgggggg 1842 atttctggtt atgtcaaggc tctggagaca ggaagggcct ttggccgcct tgggtagttg 1902 acctgccttt tctgactccg ggacgagcca gtcctaggct gcctccggga gcacttgagg 1962 tatcccgcag gccatgagga cccactgggc agctcctgga cagcctcttg gctccagccc 2022 ccacccgaaa gtggacactg gctccgccct ggccacctgg ggactggcac tgtggtgcac 2082 agtggcccaa tgtggccaac ggaagtttta taaaagacaa aatgtatatc aataaacatt 2142 ttataacttg c 2153 <210> 322 <211> 343 <212> PRT <213> Homo sapiens <400> 322 Met Ala Gly Asn Cys Ser Trp Glu Ala His Pro Gly Asn Arg Asn Arg 1 5 10 15 Met Cys Pro Gly Leu Ser Glu Ala Pro Glu Leu Tyr Ser Arg Gly Phe 20 25 30 Leu Thr Ile Glu Gln Ile Ala Met Leu Pro Pro Pro Ala Val Met Asn 35 40 45 Tyr Ile Phe Leu Leu Leu Cys Leu Cys Gly Leu Val Gly Asn Gly Leu 50 55 60 Val Leu Trp Phe Phe Gly Phe Ser Ile Lys Arg Asn Pro Phe Ser Ile 65 70 75 80 Tyr Phe Leu His Leu Ala Ser Ala Asp Val Gly Tyr Leu Phe Ser Lys 85 90 95 Ala Val Phe Ser Ile Leu Asn Thr Gly Gly Phe Leu Gly Thr Phe Ala 100 105 110 Asp Tyr Ile Arg Ser Val Cys Arg Val Leu Gly Leu Cys Met Phe Leu 115 120 125 Thr Gly Val Ser Leu Leu Pro Ala Val Ser Ala Glu Arg Cys Ala Ser 130 135 140 Val Ile Phe Pro Ala Trp Tyr Trp Arg Arg Arg Pro Lys Arg Leu Ser 145 150 155 160 Ala Val Val Cys Ala Leu Leu Trp Val Leu Ser Leu Leu Val Thr Cys 165 170 175 Leu His Asn Tyr Phe Cys Val Phe Leu Gly Arg Gly Ala Pro Gly Ala 180 185 190 Ala Cys Arg His Met Asp Ile Phe Leu Gly Ile Leu Leu Phe Leu Leu 195 200 205 Cys Cys Pro Leu Met Val Leu Pro Cys Leu Ala Leu Ile Leu His Val 210 215 220 Glu Cys Arg Ala Arg Arg Arg Gln Arg Ser Ala Lys Leu Asn His Val 225 230 235 240 Ile Leu Ala Met Val Ser Val Phe Leu Val Ser Ser Ile Tyr Leu Gly 245 250 255 Ile Asp Trp Phe Leu Phe Trp Val Phe Gln Ile Pro Ala Pro Phe Pro 260 265 270 Glu Tyr Val Thr Asp Leu Cys Ile Cys Ile Asn Ser Ser Ala Lys Pro 275 280 285 Ile Val Tyr Phe Leu Ala Gly Arg Asp Lys Ser Gln Arg Leu Trp Glu 290 295 300 Pro Leu Arg Val Val Phe Gln Arg Ala Leu Arg Asp Gly Ala Glu Leu 305 310 315 320 Gly Glu Ala Gly Gly Ser Thr Pro Asn Thr Val Thr Met Glu Met Gln 325 330 335 Cys Pro Pro Gly Asn Ala Ser 340 <210> 323 <211> 1677 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (183)..(515) <400> 323 aggctgtgga gagagcgcgg agacaagcgc agagcgcagc gcacggccac agacagccct 60 gggcatccac cgacggcgca gccggagcca gcagagccgg aaggcgcgcc ccgggcagag 120 aaagccgagc agagctgggt ggcgtctccg ggccgccgct ccgacgggcc agcgccctcc 180 cc atg tcc ctg ctc cca cgc cgc gcc cct ccg gtc agc atg agg ctc 227 Met Ser Leu Leu Pro Arg Arg Ala Pro Pro Val Ser Met Arg Leu 1 5 10 15 ctg gcg gcc gcg ctg ctc ctg ctg ctg ctg gcg ctg tac acc gcg cgt 275 Leu Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr Thr Ala Arg 20 25 30 gtg gac ggg tcc aaa tgc aag tgc tcc cgg aag gga ccc aag atc cgc 323 Val Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg 35 40 45 tac agc gac gtg aag aag ctg gaa atg aag cca aag tac ccg cac tgc 371 Tyr Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys 50 55 60 gag gag aag atg gtt atc atc acc acc aag agc gtg tcc agg tac cga 419 Glu Glu Lys Met Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg 65 70 75 ggt cag gag cac tgc ctg cac ccc aag ctg cag agc acc aag cgc ttc 467 Gly Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe 80 85 90 95 atc aag tgg tac aac gcc tgg aac gag aag cgc agg gtc tac gaa gaa 515 Ile Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 100 105 110 tagggtgaaa aacctcagaa gggaaaactc caaaccagtt gggagacttg tgcaaaggac 575 tttgcagatt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaagcctt tctttctcac 635 aggcataaga cacaaattat atattgttat gaagcacttt ttaccaacgg tcagttttta 695 cattttatag ctgcgtgcga aaggcttcca gatgggagac ccatctctct tgtgctccag 755 acttcatcac aggctgcttt ttatcaaaaa ggggaaaact catgcctttc ctttttaaaa 815 aatgcttttt tgtatttgtc catacgtcac tatacatctg agctttataa gcgcccggga 875 ggaacaatga gcttggtgga cacatttcat tgcagtgttg ctccattcct agcttgggaa 935 gcttccgctt agaggtcctg gcgcctcggc acagctgcca cgggctctcc tgggcttatg 995 gccggtcaca gcctcagtgt gactccacag tggcccctgt agccgggcaa gcaggagcag 1055 gtctctctgc atctgttctc tgaggaactc aagtttggtt gccagaaaaa tgtgcttcat 1115 tcccccctgg ttaattttta cacaccctag gaaacatttc caagatcctg tgatggcgag 1175 acaaatgatc cttaaagaag gtgtggggtc tttcccatcc tgaggatttc tgaaaggttc 1235 acaggttcaa tatttaatgc ttcagaagca tgtgaggttc ccaacactgt cagcaaaaac 1295 cttaggagaa aacttaaaaa tatatgaata catgcgcaat acacagctac agacacacat 1355 tctgttgaca agggaaaacc ttcaaagcat gtttctttcc ctcaccacaa cagaacatgc 1415 agtactaaag caatatattt gtgattcccc atgtaattct tcaatgttaa acagtgcagt 1475 cctctttcga aagctaagat gaccatgcgc cctttcctct gtacatatac ccttaagaac 1535 gccccctcca cacactgccc cccagtatat gccgcattgt actgctgtgt tatatgctat 1595 gtacatgtca gaaaccatta gcattgcatg caggtttcat attctttcta agatggaaag 1655 taataaaata tatttgaaat gt 1677 <210> 324 <211> 111 <212> PRT <213> Homo sapiens <400> 324 Met Ser Leu Leu Pro Arg Arg Ala Pro Pro Val Ser Met Arg Leu Leu 1 5 10 15 Ala Ala Ala Leu Leu Leu Leu Leu Leu Ala Leu Tyr Thr Ala Arg Val 20 25 30 Asp Gly Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr 35 40 45 Ser Asp Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu 50 55 60 Glu Lys Met Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg Gly 65 70 75 80 Gln Glu His Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe Ile 85 90 95 Lys Trp Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 100 105 110 <210> 325 <211> 1712 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (243)..(1511) <400> 325 ctccccgccg ccgccggtcc cggtgcgcgc ccatccctgc ccgcagcccc gcgcgccggc 60 cgagtcgctg agccgcggct gccggacggg acgggaccgg ctaggctggg cgcgcccccc 120 gggccccgcc gtgggcatgg gcgcactggc ccgggcgctg ctgctgcctc tgctggccca 180 gtggctcctg cgcgccgccc cggagctggc ccccgcgccc ttcacgcggc tactacctgg 240 ag atg ctg atc ggg acc ccc ccg cag aag cta cag att ctc gtt gac 287 Met Leu Ile Gly Thr Pro Pro Gln Lys Leu Gln Ile Leu Val Asp 1 5 10 15 act gga agc agt aac ttt gcc gtg gca gga acc ccg cac tcc tac ata 335 Thr Gly Ser Ser Asn Phe Ala Val Ala Gly Thr Pro His Ser Tyr Ile 20 25 30 gac acg tac ttt gac aca gag agg tct agc aca tac cgc tcc aag ggc 383 Asp Thr Tyr Phe Asp Thr Glu Arg Ser Ser Thr Tyr Arg Ser Lys Gly 35 40 45 ttt gac gtc aca gtg aag tac aca caa gga agc tgg acg ggc ttc gtt 431 Phe Asp Val Thr Val Lys Tyr Thr Gln Gly Ser Trp Thr Gly Phe Val 50 55 60 ggg gaa gac ctc gtc acc atc ccc aaa ggc ttc aat act tct ttt ctt 479 Gly Glu Asp Leu Val Thr Ile Pro Lys Gly Phe Asn Thr Ser Phe Leu 65 70 75 gtc aac att gcc act att ttt gaa tca ggg aat ttc ttt ttg cct ggg 527 Val Asn Ile Ala Thr Ile Phe Glu Ser Gly Asn Phe Phe Leu Pro Gly 80 85 90 95 att caa tgg aat gga ata ctt ggc cta gct tat gcc aca ctt gcc aag 575 Ile Gln Trp Asn Gly Ile Leu Gly Leu Ala Tyr Ala Thr Leu Ala Lys 100 105 110 cca tca agt tct ctg gag acc ttc ttc gac tcc ctg gtg aca caa gca 623 Pro Ser Ser Ser Leu Glu Thr Phe Phe Asp Ser Leu Val Thr Gln Ala 115 120 125 aac atc ccc aac gtt ttc tcc atg cag atg cgt gga gcc ggc ttg ccc 671 Asn Ile Pro Asn Val Phe Ser Met Gln Met Arg Gly Ala Gly Leu Pro 130 135 140 gtt gct gga tct ggg acc aac gga ggt agt ctt gtc ttg ggt gga att 719 Val Ala Gly Ser Gly Thr Asn Gly Gly Ser Leu Val Leu Gly Gly Ile 145 150 155 gaa cca agt ttg tat aaa gga gac atc tgg tat acc cct att aag gaa 767 Glu Pro Ser Leu Tyr Lys Gly Asp Ile Trp Tyr Thr Pro Ile Lys Glu 160 165 170 175 gag tgg tac tac cag ata gaa att ctg aaa ttg gaa att gga ggc caa 815 Glu Trp Tyr Tyr Gln Ile Glu Ile Leu Lys Leu Glu Ile Gly Gly Gln 180 185 190 agc ctt aat ctg gac tgc aga gag tat aac gca gac aag gcc atc gtg 863 Ser Leu Asn Leu Asp Cys Arg Glu Tyr Asn Ala Asp Lys Ala Ile Val 195 200 205 gac agt ggc acc acg ctg ctg cgc ctg ccc cag aag gtg ttt gat gca 911 Asp Ser Gly Thr Thr Leu Leu Arg Leu Pro Gln Lys Val Phe Asp Ala 210 215 220 gtg gtg gaa gct gtg gcc cgc gca tct ctg att cca gaa ttc tct gat 959 Val Val Glu Ala Val Ala Arg Ala Ser Leu Ile Pro Glu Phe Ser Asp 225 230 235 ggt ttc tgg act ggg tcc cag ctg gcg tgc tgg acg aat tcg gaa aca 1007 Gly Phe Trp Thr Gly Ser Gln Leu Ala Cys Trp Thr Asn Ser Glu Thr 240 245 250 255 cct tgg tct tac ttc cct aaa atc tcc atc tac ctg aga gac gag aac 1055 Pro Trp Ser Tyr Phe Pro Lys Ile Ser Ile Tyr Leu Arg Asp Glu Asn 260 265 270 tcc agc agg tca ttc cgt atc aca atc ctg cct cag ctt tac att cag 1103 Ser Ser Arg Ser Phe Arg Ile Thr Ile Leu Pro Gln Leu Tyr Ile Gln 275 280 285 ccc atg atg ggg gcc ggc ctg aat tat gaa tgt tac cga ttc ggc att 1151 Pro Met Met Gly Ala Gly Leu Asn Tyr Glu Cys Tyr Arg Phe Gly Ile 290 295 300 tcc cca tcc aca aat gcg ctg gtg atc ggt gcc acg gtg atg gag ggc 1199 Ser Pro Ser Thr Asn Ala Leu Val Ile Gly Ala Thr Val Met Glu Gly 305 310 315 ttc tac gtc atc ttc gac aga gcc cag aag agg gtg ggc ttc gca gcg 1247 Phe Tyr Val Ile Phe Asp Arg Ala Gln Lys Arg Val Gly Phe Ala Ala 320 325 330 335 agc ccc tgt gca gaa att gca ggt gct gca gtg tct gaa att tcc ggg 1295 Ser Pro Cys Ala Glu Ile Ala Gly Ala Ala Val Ser Glu Ile Ser Gly 340 345 350 cct ttc tca aca gag gat gta gcc agc aac tgt gtc ccc gct cag tct 1343 Pro Phe Ser Thr Glu Asp Val Ala Ser Asn Cys Val Pro Ala Gln Ser 355 360 365 ttg agc gag ccc att ttg tgg att gtg tcc tat gcg ctc atg agc gtc 1391 Leu Ser Glu Pro Ile Leu Trp Ile Val Ser Tyr Ala Leu Met Ser Val 370 375 380 tgt gga gcc atc ctc ctt gtc tta atc gtc ctg ctg ctg ctg ccg ttc 1439 Cys Gly Ala Ile Leu Leu Val Leu Ile Val Leu Leu Leu Leu Pro Phe 385 390 395 cgg tgt cag cgt cgc ccc cgt gac cct gag gtc gtc aat gat gag tcc 1487 Arg Cys Gln Arg Arg Pro Arg Asp Pro Glu Val Val Asn Asp Glu Ser 400 405 410 415 tct ctg gtc aga cat cgc tgg aaa tgaatagcca ggcctgacct caagcaacca 1541 Ser Leu Val Arg His Arg Trp Lys 420 tgaactcagc tattaagaaa atcacatttc cagggcagca gccgagatcg atggtggcgc 1601 tttctcctgt gcccacccgt cttcaatctc tgttctgctc ccagatgcct tctagattca 1661 ctgtcttttg attcttgatt ttcaagcttt caaatcctcc ctacttccaa g 1712 <210> 326 <211> 423 <212> PRT <213> Homo sapiens <400> 326 Met Leu Ile Gly Thr Pro Pro Gln Lys Leu Gln Ile Leu Val Asp Thr 1 5 10 15 Gly Ser Ser Asn Phe Ala Val Ala Gly Thr Pro His Ser Tyr Ile Asp 20 25 30 Thr Tyr Phe Asp Thr Glu Arg Ser Ser Thr Tyr Arg Ser Lys Gly Phe 35 40 45 Asp Val Thr Val Lys Tyr Thr Gln Gly Ser Trp Thr Gly Phe Val Gly 50 55 60 Glu Asp Leu Val Thr Ile Pro Lys Gly Phe Asn Thr Ser Phe Leu Val 65 70 75 80 Asn Ile Ala Thr Ile Phe Glu Ser Gly Asn Phe Phe Leu Pro Gly Ile 85 90 95 Gln Trp Asn Gly Ile Leu Gly Leu Ala Tyr Ala Thr Leu Ala Lys Pro 100 105 110 Ser Ser Ser Leu Glu Thr Phe Phe Asp Ser Leu Val Thr Gln Ala Asn 115 120 125 Ile Pro Asn Val Phe Ser Met Gln Met Arg Gly Ala Gly Leu Pro Val 130 135 140 Ala Gly Ser Gly Thr Asn Gly Gly Ser Leu Val Leu Gly Gly Ile Glu 145 150 155 160 Pro Ser Leu Tyr Lys Gly Asp Ile Trp Tyr Thr Pro Ile Lys Glu Glu 165 170 175 Trp Tyr Tyr Gln Ile Glu Ile Leu Lys Leu Glu Ile Gly Gly Gln Ser 180 185 190 Leu Asn Leu Asp Cys Arg Glu Tyr Asn Ala Asp Lys Ala Ile Val Asp 195 200 205 Ser Gly Thr Thr Leu Leu Arg Leu Pro Gln Lys Val Phe Asp Ala Val 210 215 220 Val Glu Ala Val Ala Arg Ala Ser Leu Ile Pro Glu Phe Ser Asp Gly 225 230 235 240 Phe Trp Thr Gly Ser Gln Leu Ala Cys Trp Thr Asn Ser Glu Thr Pro 245 250 255 Trp Ser Tyr Phe Pro Lys Ile Ser Ile Tyr Leu Arg Asp Glu Asn Ser 260 265 270 Ser Arg Ser Phe Arg Ile Thr Ile Leu Pro Gln Leu Tyr Ile Gln Pro 275 280 285 Met Met Gly Ala Gly Leu Asn Tyr Glu Cys Tyr Arg Phe Gly Ile Ser 290 295 300 Pro Ser Thr Asn Ala Leu Val Ile Gly Ala Thr Val Met Glu Gly Phe 305 310 315 320 Tyr Val Ile Phe Asp Arg Ala Gln Lys Arg Val Gly Phe Ala Ala Ser 325 330 335 Pro Cys Ala Glu Ile Ala Gly Ala Ala Val Ser Glu Ile Ser Gly Pro 340 345 350 Phe Ser Thr Glu Asp Val Ala Ser Asn Cys Val Pro Ala Gln Ser Leu 355 360 365 Ser Glu Pro Ile Leu Trp Ile Val Ser Tyr Ala Leu Met Ser Val Cys 370 375 380 Gly Ala Ile Leu Leu Val Leu Ile Val Leu Leu Leu Leu Pro Phe Arg 385 390 395 400 Cys Gln Arg Arg Pro Arg Asp Pro Glu Val Val Asn Asp Glu Ser Ser 405 410 415 Leu Val Arg His Arg Trp Lys 420 <210> 327 <211> 3017 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (141)..(1343) <400> 327 gctgggcgca cggcgcggag ccggccggag ctcgaggccg gcggcggcgg gagagcgacc 60 cgggcggcct cgtagcgggg ccccggatcc ccgagtggcg gccggagcct cgaaaagaga 120 ttctcagcgc tgattttgag atg atg ggc ttg gga aac ggg cgt cgc agc atg 173 Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met 1 5 10 aag tcg ccg ccc ctc gtg ctg gcc gcc ctg gtg gcc tgc atc atc gtc 221 Lys Ser Pro Pro Leu Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val 15 20 25 ttg ggc ttc aac tac tgg att gcg agc tcc cgg agc gtg gac ctc cag 269 Leu Gly Phe Asn Tyr Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln 30 35 40 aca cgg atc atg gag ctg gaa ggc agg gtc cgc agg gcg gct gca gag 317 Thr Arg Ile Met Glu Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu 45 50 55 aga ggc gcc gtg gag ctg aag aag aac gag ttc cag gga gag ctg gag 365 Arg Gly Ala Val Glu Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu 60 65 70 75 aag cag cgg gag cag ctt gac aaa atc cag tcc agc cac aac ttc cag 413 Lys Gln Arg Glu Gln Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln 80 85 90 ctg gag agc gtc aac aag ctg tac cag gac gaa aag gcg gtt ttg gtg 461 Leu Glu Ser Val Asn Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val 95 100 105 aat aac atc acc aca ggt gag agg ctc atc cga gtg ctg caa gac cag 509 Asn Asn Ile Thr Thr Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln 110 115 120 tta aag acc ctg cag agg aat tac ggc agg ctg cag cag gat gtc ctc 557 Leu Lys Thr Leu Gln Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu 125 130 135 cag ttt cag aag aac cag acc aac ctg gag agg aag ttc tcc tac gac 605 Gln Phe Gln Lys Asn Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp 140 145 150 155 ctg agc cag tgc atc aat cag atg aag gag gtg aag gaa cag tgt gag 653 Leu Ser Gln Cys Ile Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu 160 165 170 gag cga ata gaa gag gtc acc aaa aag ggg aat gaa gct gta gct tcc 701 Glu Arg Ile Glu Glu Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser 175 180 185 aga gac ctg agt gaa aac aac gac cag aga cag cag ctc caa gcc ctc 749 Arg Asp Leu Ser Glu Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu 190 195 200 agt gag cct cag ccc agg ctg cag gca gca ggc ctg cca cac aca gag 797 Ser Glu Pro Gln Pro Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu 205 210 215 gtg cca caa ggg aag gga aac gtg ctt ggt aac agc aag tcc cag aca 845 Val Pro Gln Gly Lys Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr 220 225 230 235 cca gcc ccc agt tcc gaa gtg gtt ttg gat tca aag aga caa gtt gag 893 Pro Ala Pro Ser Ser Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu 240 245 250 aaa gag gaa acc aat gag atc cag gtg gtg aat gag gag cct cag agg 941 Lys Glu Glu Thr Asn Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg 255 260 265 gac agg ctg ccg cag gag cca ggc cgg gag cag gtg gtg gaa gac aga 989 Asp Arg Leu Pro Gln Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg 270 275 280 cct gta ggt gga aga ggc ttc ggg gga gcc gga gaa ctg ggc cag acc 1037 Pro Val Gly Gly Arg Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr 285 290 295 cca cag gtg cag gct gcc ctg tca gtg agc cag gaa aat cca gag atg 1085 Pro Gln Val Gln Ala Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met 300 305 310 315 gag ggc cct gag cga gac cag ctt gtc atc ccc gac gga cag gag gag 1133 Glu Gly Pro Glu Arg Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu 320 325 330 gag cag gaa gct gcc ggg gaa ggg aga aac cag cag aaa ctg aga gga 1181 Glu Gln Glu Ala Ala Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly 335 340 345 gaa gat gac tac aac atg gat gaa aat gaa gca gaa tct gag aca gac 1229 Glu Asp Asp Tyr Asn Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp 350 355 360 aag caa gca gcc ctg gca ggg aat gac aga aac ata gat gtt ttt aat 1277 Lys Gln Ala Ala Leu Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn 365 370 375 gtt gaa gat cag aaa aga gac acc ata aat tta ctt gat cag cgt gaa 1325 Val Glu Asp Gln Lys Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu 380 385 390 395 aag cgg aat cat aca ctc tgaattgaac tggaatcaca tatttcacaa 1373 Lys Arg Asn His Thr Leu 400 cagggccgaa gagatgactt taaaatgttc atgagggact gaatactgaa aactgtgaaa 1433 tgtactaaat aaaatgtaca tctgaagatg attattgtga aattttagta tgcactttgt 1493 gtaggaaaaa atggaatggt cttttaaaca gcttttgggg ggtactttgg aagtgtctaa 1553 taaggtgtca caatttttgg tagtaggtat ttcgtgagaa gctcaacacc aaaactggaa 1613 catagttctc cttcaagtgt tggcgacagc ggggcttcct gattctggaa tataactttg 1673 tgtaaattaa cagccaccta tagaagagtc catctgctgt gaaggagaga cagagaactc 1733 tgggttccgt cgtcctgtcc acgtgctgta ccaagtgctg gtgccagcct gttacctgtt 1793 ctcactgaaa agtctggcta atgctcttgt gtagtcactt ctgattctga caatcaatca 1853 atcaatggcc tagagcactg actgttaaca caaacgtcac tagcaaagta gcaacagctt 1913 taagtctaaa tacaaagctg ttctgtgtga gaatttttta aaaggctact tgtataataa 1973 cccttgtcat ttttaatgta caaaacgcta ttaagtggct tagaatttga acatttgtgg 2033 tctttattta ctttgcttcg tgtgtgggca aagcaacatc ttccctaaat atatattacc 2093 aagaaaagca agaagcagat taggtttttg acaaaacaaa caggccaaaa gggggctgac 2153 ctggagcaga gcatggtgag aggcaaggca tgagagggca agttttgttg tggacagatc 2213 tgtgcctact ttattactgg agtaaaagaa aacaaagttc attgatgtcg aaggatatat 2273 acagtgttag aaattaggac tgtttagaaa aacaggaata caatggttgt ttttatcata 2333 gtgtacacat ttagcttgtg gtaaatgact cacaaaactg attttaaaat caagttaatg 2393 tgaattttga aaattactac ttaatcctaa ttcacaataa caatggcatt aaggtttgac 2453 ttgagttggt tcttagtatt atttatggta aataggctct taccacttgc aaataactgg 2513 ccacatcatt aatgactgac ttcccagtaa ggctctctaa ggggtaagta ggaggatcca 2573 caggatttga gatgctaagg ccccagagat cgtttgaacc aaccctctta ttttcagagg 2633 ggaaaatggg gcctagaagt tacagagcat ctagctggtg cgctggcacc cctggcctca 2693 cacagactcc cgagtagctg ggactacagg cacacagtca ctgaagcagg ccctgtttgc 2753 aattcacgct gccacctcca acttaaacat tcttcatatg tgatgtcctt agtcactaag 2813 gttaaacttt cccacccaga aaaggcaact tagataaaat cttagagtac tttcatactc 2873 ttctaagtcc tcttccagcc tcactttgag tcctccttgg ggttgatagg aattttctct 2933 tgctttctca ataaagtctc tattcatctc atgtttaatt tgtacgcata gaattgctga 2993 gaaataaaat gttctgttca actt 3017 <210> 328 <211> 401 <212> PRT <213> Homo sapiens <400> 328 Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 1 5 10 15 Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 20 25 30 Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 35 40 45 Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 50 55 60 Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 65 70 75 80 Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 85 90 95 Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 100 105 110 Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln 115 120 125 Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn 130 135 140 Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile 145 150 155 160 Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu 165 170 175 Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu 180 185 190 Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro 195 200 205 Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys 210 215 220 Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser 225 230 235 240 Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn 245 250 255 Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln 260 265 270 Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg 275 280 285 Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala 290 295 300 Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg 305 310 315 320 Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala 325 330 335 Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn 340 345 350 Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu 355 360 365 Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys 370 375 380 Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr 385 390 395 400 Leu <210> 329 <211> 2372 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (77)..(1255) <400> 329 aagtggccgc cggcgtccgg gtacccgagg gctctcccgc gttgctggca ccgctggcgc 60 cgcggtctcg tagcgc atg ggc ctc ctc cga ggc ggg ctc cca tgc gct cgg 112 Met Gly Leu Leu Arg Gly Gly Leu Pro Cys Ala Arg 1 5 10 gcc atg gcg cgc ctg ggc gct gtg cgc tcc cac tac tgc gcc ctg ctg 160 Ala Met Ala Arg Leu Gly Ala Val Arg Ser His Tyr Cys Ala Leu Leu 15 20 25 ctg gcc gcg gcg ctg gcc gtc tgc gcc ttc tac tac ctc ggc tca ggc 208 Leu Ala Ala Ala Leu Ala Val Cys Ala Phe Tyr Tyr Leu Gly Ser Gly 30 35 40 cgg gag acc ttc tcc agc gcc acc aag agg ctg aag gag gcc cgc gcc 256 Arg Glu Thr Phe Ser Ser Ala Thr Lys Arg Leu Lys Glu Ala Arg Ala 45 50 55 60 ggg gct ccc gcc gcg ccc tcg ccg ccc gcg ctg gag cta gcg cgg ggc 304 Gly Ala Pro Ala Ala Pro Ser Pro Pro Ala Leu Glu Leu Ala Arg Gly 65 70 75 tcc gtg gcg cca gcc ccc ggc gcg aag gcc aag agc ttg gag ggc ggc 352 Ser Val Ala Pro Ala Pro Gly Ala Lys Ala Lys Ser Leu Glu Gly Gly 80 85 90 ggt gcc ggg ccg gtg gac tac cac ctg ctg atg atg ttc acc aag gcg 400 Gly Ala Gly Pro Val Asp Tyr His Leu Leu Met Met Phe Thr Lys Ala 95 100 105 gag cac aat gcc gcg ctg cag gcc aag gcc cgc gtc gcg ctg cgc tca 448 Glu His Asn Ala Ala Leu Gln Ala Lys Ala Arg Val Ala Leu Arg Ser 110 115 120 ctg ctg cgc ctc gcc aag ttc gag gcg cac gag gtg ctt aac ctt cac 496 Leu Leu Arg Leu Ala Lys Phe Glu Ala His Glu Val Leu Asn Leu His 125 130 135 140 ttc gtg agc gag gag gcc agc cgc gag gtg gcc aag ggc ctg ctg cgg 544 Phe Val Ser Glu Glu Ala Ser Arg Glu Val Ala Lys Gly Leu Leu Arg 145 150 155 gag ctc ctg ccg ccc gcc gct ggc ttc aag tgc aag gtc atc ttc cac 592 Glu Leu Leu Pro Pro Ala Ala Gly Phe Lys Cys Lys Val Ile Phe His 160 165 170 gat gtt gct gtg ctg acg gat aag ctc ttc ccc atc gtg gag gcc atg 640 Asp Val Ala Val Leu Thr Asp Lys Leu Phe Pro Ile Val Glu Ala Met 175 180 185 cag aag cac ttc agt gct ggc ttg gga acc tac tac agt gac tcc atc 688 Gln Lys His Phe Ser Ala Gly Leu Gly Thr Tyr Tyr Ser Asp Ser Ile 190 195 200 ttc ttc ctc tcg gtc gcc atg cat cag atc atg ccc aaa gag atc ctg 736 Phe Phe Leu Ser Val Ala Met His Gln Ile Met Pro Lys Glu Ile Leu 205 210 215 220 cag atc att cag ctg gac cta gac ctg aag ttt aag acc aac atc cgg 784 Gln Ile Ile Gln Leu Asp Leu Asp Leu Lys Phe Lys Thr Asn Ile Arg 225 230 235 gag ttg ttt gag gaa ttt gac agt ttc ctg cca ggc gcc atc atc ggc 832 Glu Leu Phe Glu Glu Phe Asp Ser Phe Leu Pro Gly Ala Ile Ile Gly 240 245 250 ata gcc cgg gag atg cag cca gtt tac agg cac aca ttc tgg cag ttc 880 Ile Ala Arg Glu Met Gln Pro Val Tyr Arg His Thr Phe Trp Gln Phe 255 260 265 cgc cat gag aac ccc cag acc cgg gtt ggg ggc ccg ccc ccc gag ggg 928 Arg His Glu Asn Pro Gln Thr Arg Val Gly Gly Pro Pro Pro Glu Gly 270 275 280 ctg ccg ggc ttc aac agc ggg gtg atg ttg ctg aac ctg gag gcc atg 976 Leu Pro Gly Phe Asn Ser Gly Val Met Leu Leu Asn Leu Glu Ala Met 285 290 295 300 cgc cag tcc ccg ctc tac agc cgc ctg ctg gag ccg gcg cag gtg cag 1024 Arg Gln Ser Pro Leu Tyr Ser Arg Leu Leu Glu Pro Ala Gln Val Gln 305 310 315 cag ctg gcc gac aag tac cac ttc cgc ggc cac ctc ggg gac cag gac 1072 Gln Leu Ala Asp Lys Tyr His Phe Arg Gly His Leu Gly Asp Gln Asp 320 325 330 ttc ttc acc atg atc ggc atg gag cac ccc aag ctc ttc cat gtg ctg 1120 Phe Phe Thr Met Ile Gly Met Glu His Pro Lys Leu Phe His Val Leu 335 340 345 gac tgt acc tgg aac cgg cag ctg tgc acc tgg tgg agg gac cat ggc 1168 Asp Cys Thr Trp Asn Arg Gln Leu Cys Thr Trp Trp Arg Asp His Gly 350 355 360 tac agt gac gtc ttc gag gcc tat ttc agg tgt gag ggc cac gtc aag 1216 Tyr Ser Asp Val Phe Glu Ala Tyr Phe Arg Cys Glu Gly His Val Lys 365 370 375 380 atc tac cac ggg aac tgc aac act ccc atc ccg gag gac taggcgctcc 1265 Ile Tyr His Gly Asn Cys Asn Thr Pro Ile Pro Glu Asp 385 390 ccgtgccttg cccccggggc ctccagatct ggggggagga cagggttcct tgggacagac 1325 ccaagggcag tgtctgaccc gctagagaga caccgcaggg aagtcctgtg attaaggtgc 1385 tgagacctcc tgccgggcag gtcactgtgc tgaggccacc cgccaaggac tggcctgtgc 1445 actgctggtg cttgggacct tattcctcca gggagcaggc gacacaaagg acacgcatgt 1505 ccagtgggct gggaagcaag cacttgaaga gaaggaaggg gagaaagggt cccccttgct 1565 gtctgcctct gaggaatgga aatcctttag acccggcctt ttttggacca atataaattt 1625 aatttaaatt gacagccttc catttttcga gaaagtacaa acagaactgc tttagcaccc 1685 atcgagcccc aaacgggtaa ggtaagccaa ggttttaatg accagcccag tatctaagct 1745 tccaaacgaa taccagccca tcacatactc accctgggag gctgctgcac gcgcattctc 1805 ctgatgctca cgtcacttgg tgtaggtttc aggatcgcct ctttgaggaa ggacttcagg 1865 accaactggg gcctgcataa gaaaacttat ctcattatta gagtactcac agcttgtatc 1925 tcccagctac atcctagaac cccattgtcc tttattccac caaaccagct ccaggtgacc 1985 agactctact cagaaagcaa attcgtcatc aaagaacaga gactggccac cacaaggaca 2045 tgcaggagaa ctgtcgggac caggaagact cattccaaaa agcccaggcc gggcacagtc 2105 gtcaagcctg taatcccaac actttgggag accgaggtgg gggtatcgat tgagcctcgg 2165 aggtcgagat cagcctggga aacacaggga ggcccccatc gctacaaaat attttaaaaa 2225 ttagccaggt gtggtggctt gtgcttgttg tcccggctac ttgggaggct gaagtgggag 2285 ggtggcttga gtccaggagt tcactgcact gagctgtgat cacaccactg cactccagcc 2345 tggacgacag agtgagacgt ccatctc 2372 <210> 330 <211> 393 <212> PRT <213> Homo sapiens <400> 330 Met Gly Leu Leu Arg Gly Gly Leu Pro Cys Ala Arg Ala Met Ala Arg 1 5 10 15 Leu Gly Ala Val Arg Ser His Tyr Cys Ala Leu Leu Leu Ala Ala Ala 20 25 30 Leu Ala Val Cys Ala Phe Tyr Tyr Leu Gly Ser Gly Arg Glu Thr Phe 35 40 45 Ser Ser Ala Thr Lys Arg Leu Lys Glu Ala Arg Ala Gly Ala Pro Ala 50 55 60 Ala Pro Ser Pro Pro Ala Leu Glu Leu Ala Arg Gly Ser Val Ala Pro 65 70 75 80 Ala Pro Gly Ala Lys Ala Lys Ser Leu Glu Gly Gly Gly Ala Gly Pro 85 90 95 Val Asp Tyr His Leu Leu Met Met Phe Thr Lys Ala Glu His Asn Ala 100 105 110 Ala Leu Gln Ala Lys Ala Arg Val Ala Leu Arg Ser Leu Leu Arg Leu 115 120 125 Ala Lys Phe Glu Ala His Glu Val Leu Asn Leu His Phe Val Ser Glu 130 135 140 Glu Ala Ser Arg Glu Val Ala Lys Gly Leu Leu Arg Glu Leu Leu Pro 145 150 155 160 Pro Ala Ala Gly Phe Lys Cys Lys Val Ile Phe His Asp Val Ala Val 165 170 175 Leu Thr Asp Lys Leu Phe Pro Ile Val Glu Ala Met Gln Lys His Phe 180 185 190 Ser Ala Gly Leu Gly Thr Tyr Tyr Ser Asp Ser Ile Phe Phe Leu Ser 195 200 205 Val Ala Met His Gln Ile Met Pro Lys Glu Ile Leu Gln Ile Ile Gln 210 215 220 Leu Asp Leu Asp Leu Lys Phe Lys Thr Asn Ile Arg Glu Leu Phe Glu 225 230 235 240 Glu Phe Asp Ser Phe Leu Pro Gly Ala Ile Ile Gly Ile Ala Arg Glu 245 250 255 Met Gln Pro Val Tyr Arg His Thr Phe Trp Gln Phe Arg His Glu Asn 260 265 270 Pro Gln Thr Arg Val Gly Gly Pro Pro Pro Glu Gly Leu Pro Gly Phe 275 280 285 Asn Ser Gly Val Met Leu Leu Asn Leu Glu Ala Met Arg Gln Ser Pro 290 295 300 Leu Tyr Ser Arg Leu Leu Glu Pro Ala Gln Val Gln Gln Leu Ala Asp 305 310 315 320 Lys Tyr His Phe Arg Gly His Leu Gly Asp Gln Asp Phe Phe Thr Met 325 330 335 Ile Gly Met Glu His Pro Lys Leu Phe His Val Leu Asp Cys Thr Trp 340 345 350 Asn Arg Gln Leu Cys Thr Trp Trp Arg Asp His Gly Tyr Ser Asp Val 355 360 365 Phe Glu Ala Tyr Phe Arg Cys Glu Gly His Val Lys Ile Tyr His Gly 370 375 380 Asn Cys Asn Thr Pro Ile Pro Glu Asp 385 390 <210> 331 <211> 3520 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (40)..(1875) <400> 331 gaaattcagg ttaacgccat tgataaaggg attccttcc atg gca ggt cac agc 54 Met Ala Gly His Ser 1 5 atg gtc ctg gtg gaa att ctg gac gtg aat gac aat gtc cct gaa gta 102 Met Val Leu Val Glu Ile Leu Asp Val Asn Asp Asn Val Pro Glu Val 10 15 20 atg gtt act tca ctg tcg ctc cct gtg caa gag gat gct cag gtg ggt 150 Met Val Thr Ser Leu Ser Leu Pro Val Gln Glu Asp Ala Gln Val Gly 25 30 35 acc gtc att gcc ctg att agc gtg tcg gat cgt gac tct gga gcc aat 198 Thr Val Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ala Asn 40 45 50 gga cag gtc atc tgc tca ctg aca cct cat gtt ccc ttc aag ctg gtg 246 Gly Gln Val Ile Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val 55 60 65 tcc acc tac aag aat tac tac tcg ttg gtg ctg gac agc gcc ctg gac 294 Ser Thr Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp 70 75 80 85 cgc gag agc gtg tcg gcc tat gag ctg gtg gtg act gcg cgg gat ggg 342 Arg Glu Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly 90 95 100 ggc tcg cct tcg ctg tgg gcc acg gct aga gtg tcc gtg gag gtg gcc 390 Gly Ser Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala 105 110 115 gac gtg aac gac aat gcg cct gcg ttc gcg cag ccc gag tac aca gtg 438 Asp Val Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val 120 125 130 ttc gtg aag gag aac aac ccg ccg ggc tgc cac atc ttc acg gtg tcg 486 Phe Val Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser 135 140 145 gca tgg gac gcg gac gcg cag aag aac gcg ctg gtg tcc tac tcg ctg 534 Ala Trp Asp Ala Asp Ala Gln Lys Asn Ala Leu Val Ser Tyr Ser Leu 150 155 160 165 gtg gag cgg cgg gtg ggc gag cac gca ctg tcg agc tac gtg tcg gtg 582 Val Glu Arg Arg Val Gly Glu His Ala Leu Ser Ser Tyr Val Ser Val 170 175 180 cac gcg gag agc ggc aag gtg tac gcg ctg cag ccg cta gac cac gag 630 His Ala Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu 185 190 195 gag ctg gag ctg ctg cag ttc cag gtg agc gcg cgc gac gcc ggc gtg 678 Glu Leu Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val 200 205 210 ccg cct ctg ggc agc aac gtg acg ctg cag gtg ttc gtg ctg gac gag 726 Pro Pro Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu 215 220 225 aac gac aac gcg ccg gca ctg ctg gcg act ccg gct ggc agc gca gga 774 Asn Asp Asn Ala Pro Ala Leu Leu Ala Thr Pro Ala Gly Ser Ala Gly 230 235 240 245 ggc gca gtt agc gag ttg gta ccg cgg tcg gtg ggt gcg ggc cac gtg 822 Gly Ala Val Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val 250 255 260 gtg gcg aaa gtg cgc gcg gtg gac gct gac tcc ggc tat aac gct tgg 870 Val Ala Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp 265 270 275 ctg tcc tac gag ttg caa ccg gcg gcg gtc ggc gcg cac atc ccg ttc 918 Leu Ser Tyr Glu Leu Gln Pro Ala Ala Val Gly Ala His Ile Pro Phe 280 285 290 cac gtg ggg ctg tac act ggc gag atc agc acg aca cgc atc ctg gat 966 His Val Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ile Leu Asp 295 300 305 gag gcg gac gct ccg cgc cac cgc ctg ctg gtg ctg gtg aag gac cac 1014 Glu Ala Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His 310 315 320 325 ggt gag ccc gcg ctg acg tcc acg gcc acg gtg ctg gtg tcg ctg gtg 1062 Gly Glu Pro Ala Leu Thr Ser Thr Ala Thr Val Leu Val Ser Leu Val 330 335 340 gag aac ggc cag gcc cca aag acg tcg tcg cgg gcc tca gtg ggc gct 1110 Glu Asn Gly Gln Ala Pro Lys Thr Ser Ser Arg Ala Ser Val Gly Ala 345 350 355 gtg gat ccc gaa gcg gct ctg gtg gat att aac gtg tac ctc atc atc 1158 Val Asp Pro Glu Ala Ala Leu Val Asp Ile Asn Val Tyr Leu Ile Ile 360 365 370 gcc atc tgt gcg gtg tcc agc ctg ctg gtg ctc acg ctg ctg ttg tac 1206 Ala Ile Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr 375 380 385 act gcg ctg cgt tgc tca gcg ccg ccc acc gtg agc cgg tgc gcg ccg 1254 Thr Ala Leu Arg Cys Ser Ala Pro Pro Thr Val Ser Arg Cys Ala Pro 390 395 400 405 ggc aag ccc acg ctg gtg tgc tcc agc gcc gtg ggg agt tgg tct tac 1302 Gly Lys Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr 410 415 420 tcg cag cag agg agg cag agg gtg tgc tct gca gag agc ccg ccc aag 1350 Ser Gln Gln Arg Arg Gln Arg Val Cys Ser Ala Glu Ser Pro Pro Lys 425 430 435 acg gac ctc atg gcc ttc agc cca agc ctt cag ctg tct cga gaa gat 1398 Thr Asp Leu Met Ala Phe Ser Pro Ser Leu Gln Leu Ser Arg Glu Asp 440 445 450 tgt tta aat cct ccc agt gaa cca cga cag ccc aac cct gac tgg cgt 1446 Cys Leu Asn Pro Pro Ser Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 455 460 465 tac tct gcc tcc ctg aga gca ggc atg cac agc tct gtg cac cta gag 1494 Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 470 475 480 485 gag gct ggc att cta cgg gct ggt cca gga ggg cct gat cag cag tgg 1542 Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 490 495 500 cca aca gta tcc agt gca aca cca gaa cca gag gca gga gaa gtg tcc 1590 Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 505 510 515 cct cca gtc ggt gcg ggt gtc aac agc aac agc tgg acc ttt aaa tac 1638 Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 520 525 530 gga cca ggc aac ccc aaa caa tcc ggt ccc ggt gag ttg ccc gac aaa 1686 Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 535 540 545 ttc att atc cca gga tct cct gca atc atc tcc atc cgg cag gag cct 1734 Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 550 555 560 565 act aac agc caa att gac aaa agt gac ttc ata acc ttc ggc aaa aag 1782 Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 570 575 580 gag gag acc aag aaa aag aag aaa aag aag aag ggt aac aag acc cag 1830 Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 585 590 595 gag aaa aaa gag aaa ggg aac agc acg act gac aac agt gac cag 1875 Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 600 605 610 tgaggtcctc aaatggaaac aagccactta gccagttttt gtaataatgg caaatctctc 1935 ccatgtagca attccctgct cctttttcct atctacatga gccctcttag agacctcaga 1995 aatctgcaga aagttccctg tgtctgtcta gaacgcattt aacaggtttt gtcgtaaaag 2055 ctttactaag tctggtgtta actctttctc tccactctgg cttgttttca gaacctaaaa 2115 agcagaccca agtttccttt ctcctccgcc gcaaaggaga ggcttcccag ccccgccagt 2175 gagaggttgg actctctgcc ctgtgctccg gggatcctgt cttgatgaca cttgcagggc 2235 aggctgaaaa gttttgagat tgagcagctt gggagtttgt ggccactggg tatgtgtagc 2295 taccgcgggt atgcgagtgc cagatattgg ctgagacgag ccagcttaga ctaattggta 2355 caaggaaggc aagaaaacaa agacaaataa acagcggaag ttatcagtat ggaggggaag 2415 tgtaaactta aagggaccag actttctaaa tcttacaact caagaggtgg cagccaccct 2475 ctaggagaca aaactacccc cactgacaag gctttaggag accctaaagt ctgttggctg 2535 tgacgtcatt atacctaaaa tctgcatcat acctgcaagc caacagttca gtgttttaac 2595 agagaaccac cctgggaaac agaagcagat ctgatgtgtt tcctatacat gtcctgtgct 2655 cactttatta aaaattcttt tgcacacaat gtttatgaaa aggccagatc cttttccaat 2715 acttatgcaa aagcaaaaga aaaccccgac acctcacctt tcgctgtttg ttgtttcata 2775 gatttattta aaaaaagaga aagtctatag ctataaatct ttaaagagaa atatgaatac 2835 aattccccta aactctcctc aaaagagaat tcagtctaca gccatttaaa tgatcattgc 2895 tgctacagaa gtgctttaag agaattgcct gaaacatctg tattatatcg gccacctgcc 2955 aatcacagct ttactctttc aggtcactct ggggctgcct cttgcatgta ttactaaata 3015 aaatgatctc tctttctctc tctctctctc ttttctaaga aacaattatg tgcactttga 3075 tacacaacct tctctaacca actatatatc aagacccaaa aattgaagaa aaatattgtt 3135 ttctcataca gtgagcggat ttttcaatct actaattctg tgacttgtct tggtgtgcta 3195 gcctacacct tctctttggt ttagttttcc ttttctataa cactctgaat tgctaatctt 3255 actaacacct atgatgttac ctgaaatcaa tctcccatat gtatgctgta tgctatgcta 3315 agactcctga aatatactta ctctgtgctt gtgtatgtga atgttaatgc aactattacc 3375 tagagtgaac tttaagcttt attgttgaat gtaattccat tatatttcct tttgtacacc 3435 tgtgaaaaag tggagtagtg tttttttaac cattgttaat cagcttttgt gtatgaaaga 3495 cacagtaaaa tttctttctt aaatc 3520 <210> 332 <211> 612 <212> PRT <213> Homo sapiens <400> 332 Met Ala Gly His Ser Met Val Leu Val Glu Ile Leu Asp Val Asn Asp 1 5 10 15 Asn Val Pro Glu Val Met Val Thr Ser Leu Ser Leu Pro Val Gln Glu 20 25 30 Asp Ala Gln Val Gly Thr Val Ile Ala Leu Ile Ser Val Ser Asp Arg 35 40 45 Asp Ser Gly Ala Asn Gly Gln Val Ile Cys Ser Leu Thr Pro His Val 50 55 60 Pro Phe Lys Leu Val Ser Thr Tyr Lys Asn Tyr Tyr Ser Leu Val Leu 65 70 75 80 Asp Ser Ala Leu Asp Arg Glu Ser Val Ser Ala Tyr Glu Leu Val Val 85 90 95 Thr Ala Arg Asp Gly Gly Ser Pro Ser Leu Trp Ala Thr Ala Arg Val 100 105 110 Ser Val Glu Val Ala Asp Val Asn Asp Asn Ala Pro Ala Phe Ala Gln 115 120 125 Pro Glu Tyr Thr Val Phe Val Lys Glu Asn Asn Pro Pro Gly Cys His 130 135 140 Ile Phe Thr Val Ser Ala Trp Asp Ala Asp Ala Gln Lys Asn Ala Leu 145 150 155 160 Val Ser Tyr Ser Leu Val Glu Arg Arg Val Gly Glu His Ala Leu Ser 165 170 175 Ser Tyr Val Ser Val His Ala Glu Ser Gly Lys Val Tyr Ala Leu Gln 180 185 190 Pro Leu Asp His Glu Glu Leu Glu Leu Leu Gln Phe Gln Val Ser Ala 195 200 205 Arg Asp Ala Gly Val Pro Pro Leu Gly Ser Asn Val Thr Leu Gln Val 210 215 220 Phe Val Leu Asp Glu Asn Asp Asn Ala Pro Ala Leu Leu Ala Thr Pro 225 230 235 240 Ala Gly Ser Ala Gly Gly Ala Val Ser Glu Leu Val Pro Arg Ser Val 245 250 255 Gly Ala Gly His Val Val Ala Lys Val Arg Ala Val Asp Ala Asp Ser 260 265 270 Gly Tyr Asn Ala Trp Leu Ser Tyr Glu Leu Gln Pro Ala Ala Val Gly 275 280 285 Ala His Ile Pro Phe His Val Gly Leu Tyr Thr Gly Glu Ile Ser Thr 290 295 300 Thr Arg Ile Leu Asp Glu Ala Asp Ala Pro Arg His Arg Leu Leu Val 305 310 315 320 Leu Val Lys Asp His Gly Glu Pro Ala Leu Thr Ser Thr Ala Thr Val 325 330 335 Leu Val Ser Leu Val Glu Asn Gly Gln Ala Pro Lys Thr Ser Ser Arg 340 345 350 Ala Ser Val Gly Ala Val Asp Pro Glu Ala Ala Leu Val Asp Ile Asn 355 360 365 Val Tyr Leu Ile Ile Ala Ile Cys Ala Val Ser Ser Leu Leu Val Leu 370 375 380 Thr Leu Leu Leu Tyr Thr Ala Leu Arg Cys Ser Ala Pro Pro Thr Val 385 390 395 400 Ser Arg Cys Ala Pro Gly Lys Pro Thr Leu Val Cys Ser Ser Ala Val 405 410 415 Gly Ser Trp Ser Tyr Ser Gln Gln Arg Arg Gln Arg Val Cys Ser Ala 420 425 430 Glu Ser Pro Pro Lys Thr Asp Leu Met Ala Phe Ser Pro Ser Leu Gln 435 440 445 Leu Ser Arg Glu Asp Cys Leu Asn Pro Pro Ser Glu Pro Arg Gln Pro 450 455 460 Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 465 470 475 480 Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 485 490 495 Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 500 505 510 Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 515 520 525 Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 530 535 540 Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 545 550 555 560 Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 565 570 575 Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 580 585 590 Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 595 600 605 Asn Ser Asp Gln 610 <210> 333 <211> 1979 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (74)..(1474) <400> 333 atcaaacagt gagctgatcc gcctgatcaa caacgccatc aagaatgacc tggccagccg 60 caaccccacc ttc atg ggc ctg gcc ctg cac tgc atc gcc agc gtg ggc 109 Met Gly Leu Ala Leu His Cys Ile Ala Ser Val Gly 1 5 10 agc cgg gag atg gcc gag gcc ttc gcc ggg gag atc cct aag gtc ctc 157 Ser Arg Glu Met Ala Glu Ala Phe Ala Gly Glu Ile Pro Lys Val Leu 15 20 25 gta gcc gga gac act atg gac agc gtg aag cag agc gcg gcc ctg tgc 205 Val Ala Gly Asp Thr Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys 30 35 40 ttg ctg cgc ctg tac agg acg tcc ccc gat ctt gtc ccc atg ggc gac 253 Leu Leu Arg Leu Tyr Arg Thr Ser Pro Asp Leu Val Pro Met Gly Asp 45 50 55 60 tgg aca tcc cga gtg gtg cac ctg ctc aat gac cag cac ttg ggt gtg 301 Trp Thr Ser Arg Val Val His Leu Leu Asn Asp Gln His Leu Gly Val 65 70 75 gta act gca gcc aca agt ctg atc acc act tta gca cag aag aac cca 349 Val Thr Ala Ala Thr Ser Leu Ile Thr Thr Leu Ala Gln Lys Asn Pro 80 85 90 gaa gag ttt aaa acc tcc gtg tct ctg gct gtc tct agg cta agc aga 397 Glu Glu Phe Lys Thr Ser Val Ser Leu Ala Val Ser Arg Leu Ser Arg 95 100 105 atc gtg acg tct gca tcc aca gat ctc cag gat tac act tac tat ttt 445 Ile Val Thr Ser Ala Ser Thr Asp Leu Gln Asp Tyr Thr Tyr Tyr Phe 110 115 120 gtc ccg gct ccc tgg ctg tct gtc aaa ctg ctg aga ctg ctg cag tgc 493 Val Pro Ala Pro Trp Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys 125 130 135 140 tac cca ccc cca gac cct gca gtg cga ggc cgc ctg act gag tgc ctg 541 Tyr Pro Pro Pro Asp Pro Ala Val Arg Gly Arg Leu Thr Glu Cys Leu 145 150 155 gag acc atc ctg aac aaa gcc caa gaa ccg ccc aag tcg aag aag gtc 589 Glu Thr Ile Leu Asn Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val 160 165 170 cag tac tcc aac gcg aag aat gcc gtg ctt ttc gag gcc atc agc tta 637 Gln Tyr Ser Asn Ala Lys Asn Ala Val Leu Phe Glu Ala Ile Ser Leu 175 180 185 atc att cac cat gac agt gag ccg aac ctg ctc gtc cgt gcc tgc aac 685 Ile Ile His His Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn 190 195 200 cag ttg ggc cag ttt ctg cag cac cgc gag acc aac ctg cgc tac ctg 733 Gln Leu Gly Gln Phe Leu Gln His Arg Glu Thr Asn Leu Arg Tyr Leu 205 210 215 220 gcc ctg gag agc atg tgc acg ctg gcc agc tct gag ttc tcc cat gag 781 Ala Leu Glu Ser Met Cys Thr Leu Ala Ser Ser Glu Phe Ser His Glu 225 230 235 gct gtc aag acg cac atc gag acg gtc atc aac gcc ctg aag act gag 829 Ala Val Lys Thr His Ile Glu Thr Val Ile Asn Ala Leu Lys Thr Glu 240 245 250 cgg gac gtg agc gtg ctg ccg ccc acc ccg cct cgg agc ctc tgg gag 877 Arg Asp Val Ser Val Leu Pro Pro Thr Pro Pro Arg Ser Leu Trp Glu 255 260 265 cag cag tgc cac tgt gca tgg cgt ggg ctg agc ctt ggt gtg tgg ccg 925 Gln Gln Cys His Cys Ala Trp Arg Gly Leu Ser Leu Gly Val Trp Pro 270 275 280 tcc tgg tgg ctg cac acc tgg cgt cgt cct ggg ccc ttg gga gga gca 973 Ser Trp Trp Leu His Thr Trp Arg Arg Pro Gly Pro Leu Gly Gly Ala 285 290 295 300 cag ctg acc ctg gtt ttg ctg cag tcc cag ctg gac tgt ttt ccc agg 1021 Gln Leu Thr Leu Val Leu Leu Gln Ser Gln Leu Asp Cys Phe Pro Arg 305 310 315 cag gat ttt aat cta gaa ttt aga aac att tgt att tgt aat gac ttc 1069 Gln Asp Phe Asn Leu Glu Phe Arg Asn Ile Cys Ile Cys Asn Asp Phe 320 325 330 tgg caa aag cac gtg tcc tgg ccg gat gta act gtt ctc ctt tcc cag 1117 Trp Gln Lys His Val Ser Trp Pro Asp Val Thr Val Leu Leu Ser Gln 335 340 345 ctc ctg ttt gtg aag ggc gtc tgt tat gct cct gca gtc gcc gag gcc 1165 Leu Leu Phe Val Lys Gly Val Cys Tyr Ala Pro Ala Val Ala Glu Ala 350 355 360 ttg gat gtg cag cca ggg gag gag cgt cct gcc ggc ccc gca ggg ccc 1213 Leu Asp Val Gln Pro Gly Glu Glu Arg Pro Ala Gly Pro Ala Gly Pro 365 370 375 380 cca gga ctc cag ggt aaa gtg tgg gcc ggt ggc gca aga ctc aga ggt 1261 Pro Gly Leu Gln Gly Lys Val Trp Ala Gly Gly Ala Arg Leu Arg Gly 385 390 395 gtg ctc gtc tct ttc ctg tca gag tgg gcg tcc cca ggc cac ggt gca 1309 Val Leu Val Ser Phe Leu Ser Glu Trp Ala Ser Pro Gly His Gly Ala 400 405 410 ggc ctg agt cct tcc acc ggc ccc gtc cag tcg tcc ctg gag ggg ctg 1357 Gly Leu Ser Pro Ser Thr Gly Pro Val Gln Ser Ser Leu Glu Gly Leu 415 420 425 tgg agg aag gac gcc tct gtg tgg tca gga agt gaa ggg gcc att ggc 1405 Trp Arg Lys Asp Ala Ser Val Trp Ser Gly Ser Glu Gly Ala Ile Gly 430 435 440 cgc atg cca tgt gcc acc tgc ggc ttg tgt ctc acc tgt cat ctg gac 1453 Arg Met Pro Cys Ala Thr Cys Gly Leu Cys Leu Thr Cys His Leu Asp 445 450 455 460 tca gca ccc agg ctg cac gtc tgacacctga gaggcgagag agtggggccg 1504 Ser Ala Pro Arg Leu His Val 465 gcctaggagc caaggctggg gccttgcgct ctgtccccag gatggtggcc ttgtttgtcc 1564 taaacacacc catcagggtc tccacagctc ccctgcagtg tgtgcacccc acaatgtctg 1624 cggctcttct tccggcgtgt cgggctttga tcacagcata gccacgtcag tggcgtgcgc 1684 ctctcgcaca ggccattctg ggtctggtgg tgccaggtgc cgtgacacgc cgtgctgggc 1744 ttgtgctgca gctgggtggt gtggccctca ttctcatgtt ccagctgctg ggcagtgctc 1804 tgcctgtgtg ctgcgcctgc aggctgcgtg tgctgccgtg gatctcctgc atcccttgac 1864 ccctcccccc atcagaggaa aggctgctcc ccgaggcacc gcttccctgt gcggcgctgc 1924 agaggggccc tcagtgtggc actcctcgtc aaagaaaaat aaaggctaga actgc 1979 <210> 334 <211> 467 <212> PRT <213> Homo sapiens <400> 334 Met Gly Leu Ala Leu His Cys Ile Ala Ser Val Gly Ser Arg Glu Met 1 5 10 15 Ala Glu Ala Phe Ala Gly Glu Ile Pro Lys Val Leu Val Ala Gly Asp 20 25 30 Thr Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu 35 40 45 Tyr Arg Thr Ser Pro Asp Leu Val Pro Met Gly Asp Trp Thr Ser Arg 50 55 60 Val Val His Leu Leu Asn Asp Gln His Leu Gly Val Val Thr Ala Ala 65 70 75 80 Thr Ser Leu Ile Thr Thr Leu Ala Gln Lys Asn Pro Glu Glu Phe Lys 85 90 95 Thr Ser Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Thr Ser 100 105 110 Ala Ser Thr Asp Leu Gln Asp Tyr Thr Tyr Tyr Phe Val Pro Ala Pro 115 120 125 Trp Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro 130 135 140 Asp Pro Ala Val Arg Gly Arg Leu Thr Glu Cys Leu Glu Thr Ile Leu 145 150 155 160 Asn Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln Tyr Ser Asn 165 170 175 Ala Lys Asn Ala Val Leu Phe Glu Ala Ile Ser Leu Ile Ile His His 180 185 190 Asp Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln 195 200 205 Phe Leu Gln His Arg Glu Thr Asn Leu Arg Tyr Leu Ala Leu Glu Ser 210 215 220 Met Cys Thr Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Thr 225 230 235 240 His Ile Glu Thr Val Ile Asn Ala Leu Lys Thr Glu Arg Asp Val Ser 245 250 255 Val Leu Pro Pro Thr Pro Pro Arg Ser Leu Trp Glu Gln Gln Cys His 260 265 270 Cys Ala Trp Arg Gly Leu Ser Leu Gly Val Trp Pro Ser Trp Trp Leu 275 280 285 His Thr Trp Arg Arg Pro Gly Pro Leu Gly Gly Ala Gln Leu Thr Leu 290 295 300 Val Leu Leu Gln Ser Gln Leu Asp Cys Phe Pro Arg Gln Asp Phe Asn 305 310 315 320 Leu Glu Phe Arg Asn Ile Cys Ile Cys Asn Asp Phe Trp Gln Lys His 325 330 335 Val Ser Trp Pro Asp Val Thr Val Leu Leu Ser Gln Leu Leu Phe Val 340 345 350 Lys Gly Val Cys Tyr Ala Pro Ala Val Ala Glu Ala Leu Asp Val Gln 355 360 365 Pro Gly Glu Glu Arg Pro Ala Gly Pro Ala Gly Pro Pro Gly Leu Gln 370 375 380 Gly Lys Val Trp Ala Gly Gly Ala Arg Leu Arg Gly Val Leu Val Ser 385 390 395 400 Phe Leu Ser Glu Trp Ala Ser Pro Gly His Gly Ala Gly Leu Ser Pro 405 410 415 Ser Thr Gly Pro Val Gln Ser Ser Leu Glu Gly Leu Trp Arg Lys Asp 420 425 430 Ala Ser Val Trp Ser Gly Ser Glu Gly Ala Ile Gly Arg Met Pro Cys 435 440 445 Ala Thr Cys Gly Leu Cys Leu Thr Cys His Leu Asp Ser Ala Pro Arg 450 455 460 Leu His Val 465 <210> 335 <211> 1606 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (199)..(1488) <400> 335 gagaccgacc cgccacccgc cgtagcccgc gcgcccctgg cactcaatcc ccgccatgtg 60 ggggctcctg ctcgccctgg ccgccttcgc gccggccgtc ggccctgccc agtctcagac 120 cccaatgacc tattccttga ggcccctgcg tcgggatcct ctgaccctct agactttcag 180 catcacaatt acaaggcc atg agg aag ctg atg aag cag gta caa gag caa 231 Met Arg Lys Leu Met Lys Gln Val Gln Glu Gln 1 5 10 tgc ccc aac atc acc cgc atc tac agc att ggg aag agc tac cag ggc 279 Cys Pro Asn Ile Thr Arg Ile Tyr Ser Ile Gly Lys Ser Tyr Gln Gly 15 20 25 ctg aag ctg tat gtg atg gaa atg tcg gac aag cct ggg gag cat gag 327 Leu Lys Leu Tyr Val Met Glu Met Ser Asp Lys Pro Gly Glu His Glu 30 35 40 ctg ggg gag cct gag gtg cgc tac gtg gct ggc atg cat ggg aac gag 375 Leu Gly Glu Pro Glu Val Arg Tyr Val Ala Gly Met His Gly Asn Glu 45 50 55 gcc ctg ggg cgg gag ttg ctt ctg ctc ctg atg cag ttc ctg tgc cat 423 Ala Leu Gly Arg Glu Leu Leu Leu Leu Leu Met Gln Phe Leu Cys His 60 65 70 75 gag ttc ctg cga ggg aac cca cgg gtg acc cgg ctg ctc tct gag atg 471 Glu Phe Leu Arg Gly Asn Pro Arg Val Thr Arg Leu Leu Ser Glu Met 80 85 90 cgc att cac ctg ctg ccc tcc atg aac cct gat ggc tat gag atc gcc 519 Arg Ile His Leu Leu Pro Ser Met Asn Pro Asp Gly Tyr Glu Ile Ala 95 100 105 tac cac cgg ggt tca gag ctg gtg ggc tgg gcc gag ggc cgc tgg aac 567 Tyr His Arg Gly Ser Glu Leu Val Gly Trp Ala Glu Gly Arg Trp Asn 110 115 120 aac cag agc atc gat ctt aac cat aat ttt gct gac ctc aac aca cca 615 Asn Gln Ser Ile Asp Leu Asn His Asn Phe Ala Asp Leu Asn Thr Pro 125 130 135 ctg tgg gaa gca cag gac gat ggg aag gtg ccc cac atc gtc ccc aac 663 Leu Trp Glu Ala Gln Asp Asp Gly Lys Val Pro His Ile Val Pro Asn 140 145 150 155 cat cac ctg cca ttg ccc act tac tac acc ctg ccc aat gcc acc gtg 711 His His Leu Pro Leu Pro Thr Tyr Tyr Thr Leu Pro Asn Ala Thr Val 160 165 170 gct cct gaa acg cgg gca gta atc aag tgg atg aag cgg atc ccc ttt 759 Ala Pro Glu Thr Arg Ala Val Ile Lys Trp Met Lys Arg Ile Pro Phe 175 180 185 gtg cta agt gcc aac ctc cac ggg ggt gag ctc gtg gtg tcc tac cca 807 Val Leu Ser Ala Asn Leu His Gly Gly Glu Leu Val Val Ser Tyr Pro 190 195 200 ttc gac atg act cgc acc ccg tgg gct gcc cgc gag ctc acg ccc aca 855 Phe Asp Met Thr Arg Thr Pro Trp Ala Ala Arg Glu Leu Thr Pro Thr 205 210 215 cca gat gat gct gtg ttt cgc tgg ctc agc act gtc tat gct ggc agt 903 Pro Asp Asp Ala Val Phe Arg Trp Leu Ser Thr Val Tyr Ala Gly Ser 220 225 230 235 aat ctg gcc atg cag gac acc agc cgc cga ccc tgc cac agc cag gac 951 Asn Leu Ala Met Gln Asp Thr Ser Arg Arg Pro Cys His Ser Gln Asp 240 245 250 ttc tcc gtg cac ggc aac atc atc aac ggg gct gac tgg cac acg gtc 999 Phe Ser Val His Gly Asn Ile Ile Asn Gly Ala Asp Trp His Thr Val 255 260 265 ccc ggg agc atg aat gac ttc agc tac cta cac acc aac tgc ttt gag 1047 Pro Gly Ser Met Asn Asp Phe Ser Tyr Leu His Thr Asn Cys Phe Glu 270 275 280 gtc act gtg gag ctg tcc tgt gac aag ttc cct cac gag aat gaa ttg 1095 Val Thr Val Glu Leu Ser Cys Asp Lys Phe Pro His Glu Asn Glu Leu 285 290 295 ccc cag gag tgg gag aac aac aaa gac gcc ctc ctc acc tac ctg gag 1143 Pro Gln Glu Trp Glu Asn Asn Lys Asp Ala Leu Leu Thr Tyr Leu Glu 300 305 310 315 cag gtg cgc atg ggc att gca gga gtg gtg agg gac aag gac acg gag 1191 Gln Val Arg Met Gly Ile Ala Gly Val Val Arg Asp Lys Asp Thr Glu 320 325 330 ctt ggg att gct gac gct gtc att gcc gtg gat ggg att aac cat gac 1239 Leu Gly Ile Ala Asp Ala Val Ile Ala Val Asp Gly Ile Asn His Asp 335 340 345 gtg acc acg gcg tgg ggc ggg gat tat tgg cgt ctg ctg acc cca ggg 1287 Val Thr Thr Ala Trp Gly Gly Asp Tyr Trp Arg Leu Leu Thr Pro Gly 350 355 360 gac tac atg gtg act gcc agt gcc gag ggc tac cat tca gtg aca cgg 1335 Asp Tyr Met Val Thr Ala Ser Ala Glu Gly Tyr His Ser Val Thr Arg 365 370 375 aac tgt cgg gtc acc ttt gaa gag ggc ccc ttc ccc tgc aat ttc gtg 1383 Asn Cys Arg Val Thr Phe Glu Glu Gly Pro Phe Pro Cys Asn Phe Val 380 385 390 395 ctc acc aag act ccc aaa cag agg ctg cgc gag ctg ctg gca gct ggg 1431 Leu Thr Lys Thr Pro Lys Gln Arg Leu Arg Glu Leu Leu Ala Ala Gly 400 405 410 gcc aag gtg ccc ccg gac ctt cgc agg cgc ctg gag cgg cta agg gga 1479 Ala Lys Val Pro Pro Asp Leu Arg Arg Arg Leu Glu Arg Leu Arg Gly 415 420 425 cag aag gat tgatacctgc ggtttaagag ccctagggca ggctggacct 1528 Gln Lys Asp 430 gtcaagacgg gaaggggaag agtagagagg gagggacaaa gtgaggaaaa ggtgctcatt 1588 aaagctaccg ggcacctt 1606 <210> 336 <211> 430 <212> PRT <213> Homo sapiens <400> 336 Met Arg Lys Leu Met Lys Gln Val Gln Glu Gln Cys Pro Asn Ile Thr 1 5 10 15 Arg Ile Tyr Ser Ile Gly Lys Ser Tyr Gln Gly Leu Lys Leu Tyr Val 20 25 30 Met Glu Met Ser Asp Lys Pro Gly Glu His Glu Leu Gly Glu Pro Glu 35 40 45 Val Arg Tyr Val Ala Gly Met His Gly Asn Glu Ala Leu Gly Arg Glu 50 55 60 Leu Leu Leu Leu Leu Met Gln Phe Leu Cys His Glu Phe Leu Arg Gly 65 70 75 80 Asn Pro Arg Val Thr Arg Leu Leu Ser Glu Met Arg Ile His Leu Leu 85 90 95 Pro Ser Met Asn Pro Asp Gly Tyr Glu Ile Ala Tyr His Arg Gly Ser 100 105 110 Glu Leu Val Gly Trp Ala Glu Gly Arg Trp Asn Asn Gln Ser Ile Asp 115 120 125 Leu Asn His Asn Phe Ala Asp Leu Asn Thr Pro Leu Trp Glu Ala Gln 130 135 140 Asp Asp Gly Lys Val Pro His Ile Val Pro Asn His His Leu Pro Leu 145 150 155 160 Pro Thr Tyr Tyr Thr Leu Pro Asn Ala Thr Val Ala Pro Glu Thr Arg 165 170 175 Ala Val Ile Lys Trp Met Lys Arg Ile Pro Phe Val Leu Ser Ala Asn 180 185 190 Leu His Gly Gly Glu Leu Val Val Ser Tyr Pro Phe Asp Met Thr Arg 195 200 205 Thr Pro Trp Ala Ala Arg Glu Leu Thr Pro Thr Pro Asp Asp Ala Val 210 215 220 Phe Arg Trp Leu Ser Thr Val Tyr Ala Gly Ser Asn Leu Ala Met Gln 225 230 235 240 Asp Thr Ser Arg Arg Pro Cys His Ser Gln Asp Phe Ser Val His Gly 245 250 255 Asn Ile Ile Asn Gly Ala Asp Trp His Thr Val Pro Gly Ser Met Asn 260 265 270 Asp Phe Ser Tyr Leu His Thr Asn Cys Phe Glu Val Thr Val Glu Leu 275 280 285 Ser Cys Asp Lys Phe Pro His Glu Asn Glu Leu Pro Gln Glu Trp Glu 290 295 300 Asn Asn Lys Asp Ala Leu Leu Thr Tyr Leu Glu Gln Val Arg Met Gly 305 310 315 320 Ile Ala Gly Val Val Arg Asp Lys Asp Thr Glu Leu Gly Ile Ala Asp 325 330 335 Ala Val Ile Ala Val Asp Gly Ile Asn His Asp Val Thr Thr Ala Trp 340 345 350 Gly Gly Asp Tyr Trp Arg Leu Leu Thr Pro Gly Asp Tyr Met Val Thr 355 360 365 Ala Ser Ala Glu Gly Tyr His Ser Val Thr Arg Asn Cys Arg Val Thr 370 375 380 Phe Glu Glu Gly Pro Phe Pro Cys Asn Phe Val Leu Thr Lys Thr Pro 385 390 395 400 Lys Gln Arg Leu Arg Glu Leu Leu Ala Ala Gly Ala Lys Val Pro Pro 405 410 415 Asp Leu Arg Arg Arg Leu Glu Arg Leu Arg Gly Gln Lys Asp 420 425 430 <210> 337 <211> 30 <212> RNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized oligo-cap linker sequence <400> 337 agcaucgagu cggccuuguu ggccuacugg 30 <210> 338 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized oligo(dT) primer sequence <400> 338 gcggctgaag acggcctatg tggccttttt tttttttttt tt 42 <210> 339 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 339 agcatcgagt cggccttgtt g 21 <210> 340 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 340 gcggctgaag acggcctatg t 21 <210> 341 <211> 2194 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (309)..(1307) <400> 341 ttctaataac gtcacgtcga taaggggctt aggattgcat ctggcctgtg taagccctct 60 gagttctgcg gttcttagag ttcccttttc agcactatag ctctgccttg ttcccttgtt 120 cctccttctg gcgccccgtg ctgtgccccc tgcaggagtc caagctgtcc ccatgctgcg 180 ttctggtccg gccgcccctc ccgtggtgtg gccctggccg acccccctcc tgcgccccgc 240 ttttctcgca gaagctgctc tttgccggct cccgctctca gctggtgcag ctgcccgtgg 300 ccgactgc atg aag tat cgc tcc tgt gca gac tgt gtc ctc gcc cgg gac 350 Met Lys Tyr Arg Ser Cys Ala Asp Cys Val Leu Ala Arg Asp 1 5 10 ccc tat tgc gcc tgg agc gtc aac acc agc cgc tgt gtg gcc gtg ggt 398 Pro Tyr Cys Ala Trp Ser Val Asn Thr Ser Arg Cys Val Ala Val Gly 15 20 25 30 ggc cac tct gga tct cta ctg atc cag cat gtg atg acc tcg gac act 446 Gly His Ser Gly Ser Leu Leu Ile Gln His Val Met Thr Ser Asp Thr 35 40 45 tca ggc atc tgc aac ctc cgt ggc agt aag aaa gtc agg ccc act ccc 494 Ser Gly Ile Cys Asn Leu Arg Gly Ser Lys Lys Val Arg Pro Thr Pro 50 55 60 aaa aac atc acg gtg gtg gcg ggc aca gac ctg gtg ctg ccc tgc cac 542 Lys Asn Ile Thr Val Val Ala Gly Thr Asp Leu Val Leu Pro Cys His 65 70 75 ctc tcc tcc aac ttg gcc cat gcc cgc tgg acc ttt ggg ggc cgg gac 590 Leu Ser Ser Asn Leu Ala His Ala Arg Trp Thr Phe Gly Gly Arg Asp 80 85 90 ctg cct gcg gaa cag ccc ggg tcc ttc ctc tac gat gcc cgg ctc cag 638 Leu Pro Ala Glu Gln Pro Gly Ser Phe Leu Tyr Asp Ala Arg Leu Gln 95 100 105 110 gcc ctg gtt gtg atg gct gcc cag ccc cgc cat gcc ggg gcc tac cac 686 Ala Leu Val Val Met Ala Ala Gln Pro Arg His Ala Gly Ala Tyr His 115 120 125 tgc ttt tca gag gag cag ggg gcg cgg ctg gct gct gaa ggc tac ctt 734 Cys Phe Ser Glu Glu Gln Gly Ala Arg Leu Ala Ala Glu Gly Tyr Leu 130 135 140 gtg gct gtc gtg gca ggc ccg tcg gtg acc ttg gag gcc cgg gcc ccc 782 Val Ala Val Val Ala Gly Pro Ser Val Thr Leu Glu Ala Arg Ala Pro 145 150 155 ctg gaa aac ctg ggg ctg gtg tgg ctg gcg gtg gtg gcc ctg ggg gct 830 Leu Glu Asn Leu Gly Leu Val Trp Leu Ala Val Val Ala Leu Gly Ala 160 165 170 gtg tgc ctg gtg ctg ctg ctg ctg gtg ctg tca ttg cgc cgg cgg ctg 878 Val Cys Leu Val Leu Leu Leu Leu Val Leu Ser Leu Arg Arg Arg Leu 175 180 185 190 cgg gaa gag ctg gag aaa ggg gcc aag gct act gag agg acc ttg gtg 926 Arg Glu Glu Leu Glu Lys Gly Ala Lys Ala Thr Glu Arg Thr Leu Val 195 200 205 tac ccc ctg gag ctg ccc aag gag ccc acc agt ccc ccc ttc cgg ccc 974 Tyr Pro Leu Glu Leu Pro Lys Glu Pro Thr Ser Pro Pro Phe Arg Pro 210 215 220 tgt cct gaa cca gat gag aaa ctt tgg gat cct gtc ggt tac tac tat 1022 Cys Pro Glu Pro Asp Glu Lys Leu Trp Asp Pro Val Gly Tyr Tyr Tyr 225 230 235 tca gat ggc tcc ctt aag ata gta cct ggg cat gcc cgg tgc cag ccc 1070 Ser Asp Gly Ser Leu Lys Ile Val Pro Gly His Ala Arg Cys Gln Pro 240 245 250 ggt ggg ggg ccc cct tcg cca cct cca ggc atc cca ggc cag cct ctg 1118 Gly Gly Gly Pro Pro Ser Pro Pro Pro Gly Ile Pro Gly Gln Pro Leu 255 260 265 270 cct tct cca act cgg ctt cac ctg ggg ggt ggg cgg aac tca aat gcc 1166 Pro Ser Pro Thr Arg Leu His Leu Gly Gly Gly Arg Asn Ser Asn Ala 275 280 285 aat ggt tac gtg cgc tta caa cta gga ggg gag gac cgg gga ggg ctc 1214 Asn Gly Tyr Val Arg Leu Gln Leu Gly Gly Glu Asp Arg Gly Gly Leu 290 295 300 ggg cac ccc ctg cct gag ctc gcg gat gaa ctg aga cgc aaa ctg cag 1262 Gly His Pro Leu Pro Glu Leu Ala Asp Glu Leu Arg Arg Lys Leu Gln 305 310 315 caa cgc cag cca ctg ccc gac tcc aac ccc gag gag tca tca gta 1307 Gln Arg Gln Pro Leu Pro Asp Ser Asn Pro Glu Glu Ser Ser Val 320 325 330 tgaggggaac ccccaccgcg tcggcgggaa gcgtgggagg tgtagctcct acttttgcac 1367 aggcaccagc tacctcaggg acatggcacg ggcacctgct ctgtctggga cagatactgc 1427 ccagcaccca cccggccatg aggacctgct ctgctcagca cgggcactgc cacttggtgt 1487 ggctcaccag ggcaccagcc tcgcagaagg catcttcctc ctctctgtga atcacagaca 1547 cgcgggaccc cagccgccaa aacttttcaa ggcagaagtt tcaagatgtg tgtttgtctg 1607 tatttgcaca tgtgtttgtg tgtgtgtgta tgtgtgtgtg cacgcgcgtg cgcgcttgtg 1667 gcatagcctt cctgtttctg tcaagtcttc ccttggcctg ggtcctcctg gtgagtcatt 1727 ggagctatga aggggaaggg gtcgtatcac tttgtctctc ctacccccac tgccccgagt 1787 gtcgggcagc gatgtacata tggaggtggg gtggacaggg tgctgtgccc cttcagaggg 1847 agtgcagggc ttggggtggg cctagtcctg ctcctagggc tgtgaatgtt ttcagggtgg 1907 ggggagggag atggagcctc ctgtgtgttt ggggggaagg gtgggtgggg cctcccactt 1967 ggccccgggg ttcagtggta ttttatactt gccttcttcc tgtacagggc tgggaaaggc 2027 tgtgtgaggg gagagaaggg agagggtggg cctgctgtgg acaatggcat actctcttcc 2087 agccctagga ggagggctcc taacagtgta acttattgtg tccccgcgta tttatttgtt 2147 gtaaatattt gagtattttt atattgacaa ataaaatgga gaaaatg 2194 <210> 342 <211> 333 <212> PRT <213> Homo sapiens <400> 342 Met Lys Tyr Arg Ser Cys Ala Asp Cys Val Leu Ala Arg Asp Pro Tyr 1 5 10 15 Cys Ala Trp Ser Val Asn Thr Ser Arg Cys Val Ala Val Gly Gly His 20 25 30 Ser Gly Ser Leu Leu Ile Gln His Val Met Thr Ser Asp Thr Ser Gly 35 40 45 Ile Cys Asn Leu Arg Gly Ser Lys Lys Val Arg Pro Thr Pro Lys Asn 50 55 60 Ile Thr Val Val Ala Gly Thr Asp Leu Val Leu Pro Cys His Leu Ser 65 70 75 80 Ser Asn Leu Ala His Ala Arg Trp Thr Phe Gly Gly Arg Asp Leu Pro 85 90 95 Ala Glu Gln Pro Gly Ser Phe Leu Tyr Asp Ala Arg Leu Gln Ala Leu 100 105 110 Val Val Met Ala Ala Gln Pro Arg His Ala Gly Ala Tyr His Cys Phe 115 120 125 Ser Glu Glu Gln Gly Ala Arg Leu Ala Ala Glu Gly Tyr Leu Val Ala 130 135 140 Val Val Ala Gly Pro Ser Val Thr Leu Glu Ala Arg Ala Pro Leu Glu 145 150 155 160 Asn Leu Gly Leu Val Trp Leu Ala Val Val Ala Leu Gly Ala Val Cys 165 170 175 Leu Val Leu Leu Leu Leu Val Leu Ser Leu Arg Arg Arg Leu Arg Glu 180 185 190 Glu Leu Glu Lys Gly Ala Lys Ala Thr Glu Arg Thr Leu Val Tyr Pro 195 200 205 Leu Glu Leu Pro Lys Glu Pro Thr Ser Pro Pro Phe Arg Pro Cys Pro 210 215 220 Glu Pro Asp Glu Lys Leu Trp Asp Pro Val Gly Tyr Tyr Tyr Ser Asp 225 230 235 240 Gly Ser Leu Lys Ile Val Pro Gly His Ala Arg Cys Gln Pro Gly Gly 245 250 255 Gly Pro Pro Ser Pro Pro Pro Gly Ile Pro Gly Gln Pro Leu Pro Ser 260 265 270 Pro Thr Arg Leu His Leu Gly Gly Gly Arg Asn Ser Asn Ala Asn Gly 275 280 285 Tyr Val Arg Leu Gln Leu Gly Gly Glu Asp Arg Gly Gly Leu Gly His 290 295 300 Pro Leu Pro Glu Leu Ala Asp Glu Leu Arg Arg Lys Leu Gln Gln Arg 305 310 315 320 Gln Pro Leu Pro Asp Ser Asn Pro Glu Glu Ser Ser Val 325 330 <210> 343 <211> 2788 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (22)..(1026) <400> 343 atagaaggaa gaggagcgaa c atg gca gcg cgt tgg cgg ttt tgg tgt gtc 51 Met Ala Ala Arg Trp Arg Phe Trp Cys Val 1 5 10 tct gtg acc atg gtg gtg gcg ctg ctc atc gtt tgc gac gtt ccc tca 99 Ser Val Thr Met Val Val Ala Leu Leu Ile Val Cys Asp Val Pro Ser 15 20 25 gcc tct gcc aaa aga aag aag gag atg gtg tta tct gaa aag gtt agt 147 Ala Ser Ala Lys Arg Lys Lys Glu Met Val Leu Ser Glu Lys Val Ser 30 35 40 cag ctg atg gaa tgg act aac aaa aga cct gta ata aga atg aat gga 195 Gln Leu Met Glu Trp Thr Asn Lys Arg Pro Val Ile Arg Met Asn Gly 45 50 55 gac aag ttc cgt cgc ctt gtg aaa gcc cca ccg aga aat tac tcc gtt 243 Asp Lys Phe Arg Arg Leu Val Lys Ala Pro Pro Arg Asn Tyr Ser Val 60 65 70 atc gtc atg ttc act gct ctc caa ctg cat aga cag tgt gtc gtt tgc 291 Ile Val Met Phe Thr Ala Leu Gln Leu His Arg Gln Cys Val Val Cys 75 80 85 90 aag caa gct gat gaa gaa ttc cag atc ctg gca aac tcc tgg cga tac 339 Lys Gln Ala Asp Glu Glu Phe Gln Ile Leu Ala Asn Ser Trp Arg Tyr 95 100 105 tcc agt gca ttc acc aac agg ata ttt ttt gcc atg gtg gat ttt gat 387 Ser Ser Ala Phe Thr Asn Arg Ile Phe Phe Ala Met Val Asp Phe Asp 110 115 120 gaa ggc tct gat gta ttt cag atg cta aac atg aat tca gct cca act 435 Glu Gly Ser Asp Val Phe Gln Met Leu Asn Met Asn Ser Ala Pro Thr 125 130 135 ttc atc aac ttt cct gca aaa ggg aaa ccc aaa cgg ggt gat aca tat 483 Phe Ile Asn Phe Pro Ala Lys Gly Lys Pro Lys Arg Gly Asp Thr Tyr 140 145 150 gag tta cag gtg cgg ggt ttt tca gct gag cag att gcc cgg tgg atc 531 Glu Leu Gln Val Arg Gly Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile 155 160 165 170 gcc gac aga act gat gtc aat att aga gtg att aga ccc cca aat tat 579 Ala Asp Arg Thr Asp Val Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr 175 180 185 gct ggt ccc ctt atg ttg gga ttg ctt ttg gct gtt att ggt gga ctt 627 Ala Gly Pro Leu Met Leu Gly Leu Leu Leu Ala Val Ile Gly Gly Leu 190 195 200 gtg tat ctt cga aga agt aat atg gaa ttt ctc ttt aat aaa act gga 675 Val Tyr Leu Arg Arg Ser Asn Met Glu Phe Leu Phe Asn Lys Thr Gly 205 210 215 tgg gct ttt gca gct ttg tgt ttt gtg ctt gct atg aca tct ggt caa 723 Trp Ala Phe Ala Ala Leu Cys Phe Val Leu Ala Met Thr Ser Gly Gln 220 225 230 atg tgg aac cat ata aga gga cca cca tat gcc cat aag aat ccc cac 771 Met Trp Asn His Ile Arg Gly Pro Pro Tyr Ala His Lys Asn Pro His 235 240 245 250 acg gga cat gtg aat tat atc cat gga agc agt caa gcc cag ttt gta 819 Thr Gly His Val Asn Tyr Ile His Gly Ser Ser Gln Ala Gln Phe Val 255 260 265 gct gaa aca cac att gtt ctt ctg ttt aat ggt gga gtt acc tta gga 867 Ala Glu Thr His Ile Val Leu Leu Phe Asn Gly Gly Val Thr Leu Gly 270 275 280 atg gtg ctt tta tgt gaa gct gct acc tct gac atg gat att gga aag 915 Met Val Leu Leu Cys Glu Ala Ala Thr Ser Asp Met Asp Ile Gly Lys 285 290 295 cga aag ata atg tgt gtg gct ggt att gga ctt gtt gta tta ttc ttc 963 Arg Lys Ile Met Cys Val Ala Gly Ile Gly Leu Val Val Leu Phe Phe 300 305 310 agt tgg atg ctc tct att ttt aga tct aaa tat cat ggc tac cca tac 1011 Ser Trp Met Leu Ser Ile Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr 315 320 325 330 agc ttt ctg atg agt taaaaaggtc ccagagatat atagacactg gagtactgga 1066 Ser Phe Leu Met Ser 335 aattgaaaaa cgaaaatcgt gtgtgtttga aaagaagaat gcaacttgta tattttgtat 1126 tacctctttt tttcaagtga tttaaatagt taatcattta accaaagaag atgtgtagtg 1186 ccttaacaag caatcctctg tcaaaatctg aggtatttga aaataattat cctcttaacc 1246 ttctcttccc agtgaacttt atggaacatt taatttagta caattaagta tattataaaa 1306 attgtaaaac tactactttg ttttagttag aacaaagctc aaaactactt tagttaactt 1366 ggtcatctga ttttatattg ccttatccaa agatggggaa agtaagtcct gaccaggtgt 1426 tcccacatat gcctgttaca gataactaca ttaggaattc attcttagct tcttcatctt 1486 tgtgtggatg tgtatacttt acgcatcttt ccttttgagt agagaaatta tgtgtgtcat 1546 gtggtcttct gaaaatggaa caccattctt cagagcacac gtctagccct cagcaagaca 1606 gttgtttctc ctcctccttg catatttcct actgaaatac agtgctgtct atgattgttt 1666 ttgttttgtt gtttttttga gacggtctcg ctgtgtcaca caggctggag tgcagtggcg 1726 tgagctcggc tgactgcaaa ctctgcctcc caggtttaag cgattctcct gtcacagctt 1786 cccaagtagc tgggatttac aggtgtgcac cgccatgcca ggctaatttt tgtgttttta 1846 gtagagacag ggtttcgcca agttgtccag gctggtcttg aactcctggg ctcaagtgat 1906 ccgcccgcct cagtctccca aagtgcgagg atgacatgtg tgagctacca caccagcaat 1966 gtctatgctt ctcgatagct gtgaacatga aaagacatct attgggagtc cgaggcaggt 2026 ggattgcttg aggccaggag ttagagacca gcctggccaa caaggcaaaa ccccgtctct 2086 actaaaaata tgaaaattag ctgggcttgg tggctcatgc ctataatcct agctacttgg 2146 gaggctgagg cacgagactt gcttaatacc tgggaggcgg agattgcagt gagccgagat 2206 cacgctactg cgctccagcc tgagtgatag agtgagactc tgtctcaaaa aaaagtatct 2266 ctaaatacag gattataatt tctgcttgag tatggtgtta actaccttgt atttagaaag 2326 atttcagatt cattccatct ccttagtttt cttttaaggt gacccatctg tgataaaaat 2386 atagcttagt gctaaaatca gtgtaactta tacatggcct aaaatgtttc tacaaattag 2446 agtttgtcac ttattccatt tgtacctaag agaaaaatag gctcagttag aaaaggactc 2506 cctggccagg cgcagtgact tacgcctgta atctcagcac tttgggaggc caaggcaggc 2566 agatcacgag gtcaggagtt cgagaccatc ctggccaaca tggtgaaacc ccgtctctac 2626 taaaaatata aaaattagct gggtgtggtg gcaggagcct gtaatcccag ctacacagga 2686 ggctgaggca cgagaatcac ttgaactcag gagatggagg tttcagtgag ccaagatcac 2746 accactgcac tccagcctgg caacagagcg agactccatc tc 2788 <210> 344 <211> 335 <212> PRT <213> Homo sapiens <400> 344 Met Ala Ala Arg Trp Arg Phe Trp Cys Val Ser Val Thr Met Val Val 1 5 10 15 Ala Leu Leu Ile Val Cys Asp Val Pro Ser Ala Ser Ala Lys Arg Lys 20 25 30 Lys Glu Met Val Leu Ser Glu Lys Val Ser Gln Leu Met Glu Trp Thr 35 40 45 Asn Lys Arg Pro Val Ile Arg Met Asn Gly Asp Lys Phe Arg Arg Leu 50 55 60 Val Lys Ala Pro Pro Arg Asn Tyr Ser Val Ile Val Met Phe Thr Ala 65 70 75 80 Leu Gln Leu His Arg Gln Cys Val Val Cys Lys Gln Ala Asp Glu Glu 85 90 95 Phe Gln Ile Leu Ala Asn Ser Trp Arg Tyr Ser Ser Ala Phe Thr Asn 100 105 110 Arg Ile Phe Phe Ala Met Val Asp Phe Asp Glu Gly Ser Asp Val Phe 115 120 125 Gln Met Leu Asn Met Asn Ser Ala Pro Thr Phe Ile Asn Phe Pro Ala 130 135 140 Lys Gly Lys Pro Lys Arg Gly Asp Thr Tyr Glu Leu Gln Val Arg Gly 145 150 155 160 Phe Ser Ala Glu Gln Ile Ala Arg Trp Ile Ala Asp Arg Thr Asp Val 165 170 175 Asn Ile Arg Val Ile Arg Pro Pro Asn Tyr Ala Gly Pro Leu Met Leu 180 185 190 Gly Leu Leu Leu Ala Val Ile Gly Gly Leu Val Tyr Leu Arg Arg Ser 195 200 205 Asn Met Glu Phe Leu Phe Asn Lys Thr Gly Trp Ala Phe Ala Ala Leu 210 215 220 Cys Phe Val Leu Ala Met Thr Ser Gly Gln Met Trp Asn His Ile Arg 225 230 235 240 Gly Pro Pro Tyr Ala His Lys Asn Pro His Thr Gly His Val Asn Tyr 245 250 255 Ile His Gly Ser Ser Gln Ala Gln Phe Val Ala Glu Thr His Ile Val 260 265 270 Leu Leu Phe Asn Gly Gly Val Thr Leu Gly Met Val Leu Leu Cys Glu 275 280 285 Ala Ala Thr Ser Asp Met Asp Ile Gly Lys Arg Lys Ile Met Cys Val 290 295 300 Ala Gly Ile Gly Leu Val Val Leu Phe Phe Ser Trp Met Leu Ser Ile 305 310 315 320 Phe Arg Ser Lys Tyr His Gly Tyr Pro Tyr Ser Phe Leu Met Ser 325 330 335 <210> 345 <211> 1419 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (58)..(801) <400> 345 acactacctt cccgaagttg aaggcaagcg gtgattgttt gtagacggcg ctttgtc 57 atg gga cct gtg cgg ttg gga ata ttg ctt ttc ctt ttt ttg gcc gtg 105 Met Gly Pro Val Arg Leu Gly Ile Leu Leu Phe Leu Phe Leu Ala Val 1 5 10 15 cac gag gct tgg gct ggg atg ttg aag gag gag gac gat gac aca gaa 153 His Glu Ala Trp Ala Gly Met Leu Lys Glu Glu Asp Asp Asp Thr Glu 20 25 30 cgc ttg ccc agc aaa tgc gaa gtg tgt aag ctg ctg agc aca gag cta 201 Arg Leu Pro Ser Lys Cys Glu Val Cys Lys Leu Leu Ser Thr Glu Leu 35 40 45 cag gcg gaa ctg agt cgc acc ggt cga tct cga gag gtg ctg gag ctg 249 Gln Ala Glu Leu Ser Arg Thr Gly Arg Ser Arg Glu Val Leu Glu Leu 50 55 60 ggg cag gtg ctg gat aca ggc aag agg aag aga cac gtg cct tac agc 297 Gly Gln Val Leu Asp Thr Gly Lys Arg Lys Arg His Val Pro Tyr Ser 65 70 75 80 gtt tca gag aca agg ctg gaa gag gcc tta gag aat tta tgt gag cgg 345 Val Ser Glu Thr Arg Leu Glu Glu Ala Leu Glu Asn Leu Cys Glu Arg 85 90 95 atc ctg gac tat agt gtt cac gct gag cgc aag ggc tca ctg aga tat 393 Ile Leu Asp Tyr Ser Val His Ala Glu Arg Lys Gly Ser Leu Arg Tyr 100 105 110 gcc aag ggt cag agt cag acc atg gca aca ctg aaa ggc cta gtg cag 441 Ala Lys Gly Gln Ser Gln Thr Met Ala Thr Leu Lys Gly Leu Val Gln 115 120 125 aag ggg gtg aag gtg gat ctg ggg atc cct ctg gag ctt tgg gat gag 489 Lys Gly Val Lys Val Asp Leu Gly Ile Pro Leu Glu Leu Trp Asp Glu 130 135 140 ccc agc gtg gag gtc aca tac ctc aag aag cag tgt gag acc atg ttg 537 Pro Ser Val Glu Val Thr Tyr Leu Lys Lys Gln Cys Glu Thr Met Leu 145 150 155 160 gag gag ttt gaa gac att gtg gga gac tgg tac ttc cac cat cag gag 585 Glu Glu Phe Glu Asp Ile Val Gly Asp Trp Tyr Phe His His Gln Glu 165 170 175 cag ccc cta caa aat ttt ctc tgt gaa ggt cat gtg ctc cca gct gct 633 Gln Pro Leu Gln Asn Phe Leu Cys Glu Gly His Val Leu Pro Ala Ala 180 185 190 gaa act gca tgt cta cag gaa act tgg act gga aag gag atc aca gat 681 Glu Thr Ala Cys Leu Gln Glu Thr Trp Thr Gly Lys Glu Ile Thr Asp 195 200 205 ggg gaa gag aaa aca gaa ggg gag gaa gag cag gag gag gag gag gaa 729 Gly Glu Glu Lys Thr Glu Gly Glu Glu Glu Gln Glu Glu Glu Glu Glu 210 215 220 gag gag gaa gag gaa ggg gga gac aag atg acc aag aca gga agc cac 777 Glu Glu Glu Glu Glu Gly Gly Asp Lys Met Thr Lys Thr Gly Ser His 225 230 235 240 ccc aaa ctt gac cga gaa gat ctt tgacccttgc ctttgagccc ccaggagggg 831 Pro Lys Leu Asp Arg Glu Asp Leu 245 aagggatcat ggagagccct ctaaagcctg cactctccct gctccacagc tttcagggtg 891 tgtttatgag tgactccacc caagcttgta gctgttctct cccatctaac ctcaggcaag 951 atcctggtga aacagcatga catggcttct ggggtggagg gtgggggtgg aggtcctgct 1011 cctagagatg aactctattc agccccttaa ttggcaggtg tatgtgctga cagtactgaa 1071 agctttcctc tttaactgat cccaccccca cccaaaagtc agcagtggca ctggagctgt 1131 gggctttggg gaagtcactt agctccttaa ggtctgtttt tagacccttc caaggaagag 1191 gccagaacgg acattctctg cgatctatat acattgcctg tatccaggag gctacacacc 1251 agcaaaccgt gaaggagaat gggacactgg gtcatggcct ggagttgctg ataatttagg 1311 tgggatagat acttggtcta cttaagctca atgtaaccca gagcccacca tatagtttta 1371 taggtgctca attttctata tcgctattaa acttttttct ttttttct 1419 <210> 346 <211> 248 <212> PRT <213> Homo sapiens <400> 346 Met Gly Pro Val Arg Leu Gly Ile Leu Leu Phe Leu Phe Leu Ala Val 1 5 10 15 His Glu Ala Trp Ala Gly Met Leu Lys Glu Glu Asp Asp Asp Thr Glu 20 25 30 Arg Leu Pro Ser Lys Cys Glu Val Cys Lys Leu Leu Ser Thr Glu Leu 35 40 45 Gln Ala Glu Leu Ser Arg Thr Gly Arg Ser Arg Glu Val Leu Glu Leu 50 55 60 Gly Gln Val Leu Asp Thr Gly Lys Arg Lys Arg His Val Pro Tyr Ser 65 70 75 80 Val Ser Glu Thr Arg Leu Glu Glu Ala Leu Glu Asn Leu Cys Glu Arg 85 90 95 Ile Leu Asp Tyr Ser Val His Ala Glu Arg Lys Gly Ser Leu Arg Tyr 100 105 110 Ala Lys Gly Gln Ser Gln Thr Met Ala Thr Leu Lys Gly Leu Val Gln 115 120 125 Lys Gly Val Lys Val Asp Leu Gly Ile Pro Leu Glu Leu Trp Asp Glu 130 135 140 Pro Ser Val Glu Val Thr Tyr Leu Lys Lys Gln Cys Glu Thr Met Leu 145 150 155 160 Glu Glu Phe Glu Asp Ile Val Gly Asp Trp Tyr Phe His His Gln Glu 165 170 175 Gln Pro Leu Gln Asn Phe Leu Cys Glu Gly His Val Leu Pro Ala Ala 180 185 190 Glu Thr Ala Cys Leu Gln Glu Thr Trp Thr Gly Lys Glu Ile Thr Asp 195 200 205 Gly Glu Glu Lys Thr Glu Gly Glu Glu Glu Gln Glu Glu Glu Glu Glu 210 215 220 Glu Glu Glu Glu Glu Gly Gly Asp Lys Met Thr Lys Thr Gly Ser His 225 230 235 240 Pro Lys Leu Asp Arg Glu Asp Leu 245 <210> 347 <211> 2617 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (143)..(613) <400> 347 tcttccgggc gccgcagctt cctgccaagc accgcgcagc cgcctccgcc gcaggatccc 60 ccggtgcagg cctccgtgct ggtgcggatc ctggagctca gccgcgcgcg ccctgcccga 120 tcctgtgccg acccaccgca ct atg cgc gcc gtg ccg ctg ccc gcc ccg ctc 172 Met Arg Ala Val Pro Leu Pro Ala Pro Leu 1 5 10 ctg ccg ctg ctg ctg ctc gcg ctc ctg gcc gct ccc acc gcc cgc gcc 220 Leu Pro Leu Leu Leu Leu Ala Leu Leu Ala Ala Pro Thr Ala Arg Ala 15 20 25 agc aga gcc gag tcc gtc tcc gcg ccg cgg ccc gaa ccc gag cgc gag 268 Ser Arg Ala Glu Ser Val Ser Ala Pro Arg Pro Glu Pro Glu Arg Glu 30 35 40 tcg cgg cca ccg ccc ggc ccg ggg ccc ggg aac acc acc cgg ttt ggg 316 Ser Arg Pro Pro Pro Gly Pro Gly Pro Gly Asn Thr Thr Arg Phe Gly 45 50 55 tct ggg gcg gcg ggc ggc agc ggc agc tcc aac agc agc ggc gac gcc 364 Ser Gly Ala Ala Gly Gly Ser Gly Ser Ser Asn Ser Ser Gly Asp Ala 60 65 70 ttg gtg acc cgc att tcc atc ctc ctc cgc gac cta ccc acc ctc aag 412 Leu Val Thr Arg Ile Ser Ile Leu Leu Arg Asp Leu Pro Thr Leu Lys 75 80 85 90 gca gcc gtg atc gtg gcg ttc gcc ttt acc acc ctc ctc atc gcc tgc 460 Ala Ala Val Ile Val Ala Phe Ala Phe Thr Thr Leu Leu Ile Ala Cys 95 100 105 ctg ctg ctg cgc gtc ttc agg tcg gga aag agg tta aag aag aca cgc 508 Leu Leu Leu Arg Val Phe Arg Ser Gly Lys Arg Leu Lys Lys Thr Arg 110 115 120 aag tat gat atc atc acc act cca gca gag cga gtg gaa atg gcg cca 556 Lys Tyr Asp Ile Ile Thr Thr Pro Ala Glu Arg Val Glu Met Ala Pro 125 130 135 cta aat gaa gag gat gat gaa gat gag gac tcc aca gta ttc gac atc 604 Leu Asn Glu Glu Asp Asp Glu Asp Glu Asp Ser Thr Val Phe Asp Ile 140 145 150 aaa tac agg taaaacctgt ttcccagcct ggtggcatcc tgtggaaagt 653 Lys Tyr Arg 155 tggtcagctg caacctgggg tgtgaaggac tggacctgga agccctcttg cgtcggaggt 713 gttgaaacca aaacgaacgt tatgtataaa accccagctc catcgtgcgt gtcaggcatc 773 tgctcagact gtcactggca agctcgtttc cacgtcacca caatggagtt gcttctgcca 833 ccctttgggc atccctttaa agtgccccct acttctactc cccatgtaag aggctttgtg 893 ccttgctaag gagcaaaggg tagaaacatg ttgattttaa agaagttttt ttaagacaat 953 tgttgacaat agtaaaagag atcaggagga tcaagaatct aaaacaagcc tgaaggatgt 1013 ccaactgtgt atttagaatt tccgacattc ttctctactg gatctacaca ttggacccca 1073 tctgatcctt tgctgctttt ttggcttggt caggtcctgg cctcattttg gcgttacctg 1133 tgtcagagtt caaggtggat gtgcttagag ctggtcagcc ccttccagac ctggacacgt 1193 ctgtggctcc ttttctttct tccttttttt ttttaaaaaa aaaaaaggtt cagcagaaat 1253 cagcgtggct agttcacaaa gaatttccag tatcagggaa aaactgtgcg tgtgtgtgtg 1313 tgtgtgtgtg cacgtgtgtg cgtgtgcacg tgtgtgatac ctataaaaca gtttctcctt 1373 ctctgaaggg aaaggaaagt gctaggcagc ctgtgattag caacattctt tgtgcttttt 1433 tgttgttcct ctgctctgtc acagttctac gttgtttgcc ttagaaatgt aatttttaaa 1493 aaccatttta aaaatgaacg gtgatttggc tggctggaaa aaatcacact gtcaggggac 1553 tatatttgaa gtcagtctag acggggctgg actaggaacc cacctggacc caggagaccc 1613 cacaggaccc aggaggtccc tgccggaagg cagaggttca ggtgagagtg gctcacctct 1673 gagctggtga agtgaggact tgcctgtgac atgacccagg gatctgctgc tggcttctgg 1733 agacagggcc ttgggctgac ttctcaggtt gattgaggcc tcctgactag cggtgttccc 1793 aggctagagg tgattggctg caacaaagat gcttctatta gtctattagc agtgccttcg 1853 ggaccctggg attttgctct ctctagaaag gtgtttttta tttttttatt ttttatctcc 1913 cccttttttc ctggctttgc tccagggttt gtgtatttgc ctgtttattg tcctgctctt 1973 tttttttttg gatgaaaact ccagcctttc ctgactcacc tccatcttcg gttcttcagt 2033 tttctgagaa gagttgggat atgtgggaag gggcatggga gctcggcagc ctccgcctgc 2093 caggaaggca gtttcgcctc tgcaggaaag agcagagccc gtgggaagcc ctgggtgagg 2153 gtggcgcagc cggcccagca cgcatggtat tgccagccac ggggggcctg cgtgtagtct 2213 ctgctccctg catttcacct tctttgttga ctttccttcc ctgttttccc ccatctgttt 2273 gccagagggg tgggactggc aacagaacag ccgtggctgc tttatctctc ctctccacgg 2333 tgtactcagg cctgagtggt gactcacggg agcctggcca cctcgcagct gttcgccccc 2393 tcaacctttg aactggaact gctggctcac acagggtttt cgacaactgc agctgaatct 2453 catggaaaag ctggattcct ctgccttacg cagaaacacc cgggctccat ctgccaggtg 2513 cttgccactg gtcctggcag aaatggcggc tgctgaaagt gaccttccaa atccttggtg 2573 gcacttcagc gccacaggct ctccaataaa aaccctttac acac 2617 <210> 348 <211> 157 <212> PRT <213> Homo sapiens <400> 348 Met Arg Ala Val Pro Leu Pro Ala Pro Leu Leu Pro Leu Leu Leu Leu 1 5 10 15 Ala Leu Leu Ala Ala Pro Thr Ala Arg Ala Ser Arg Ala Glu Ser Val 20 25 30 Ser Ala Pro Arg Pro Glu Pro Glu Arg Glu Ser Arg Pro Pro Pro Gly 35 40 45 Pro Gly Pro Gly Asn Thr Thr Arg Phe Gly Ser Gly Ala Ala Gly Gly 50 55 60 Ser Gly Ser Ser Asn Ser Ser Gly Asp Ala Leu Val Thr Arg Ile Ser 65 70 75 80 Ile Leu Leu Arg Asp Leu Pro Thr Leu Lys Ala Ala Val Ile Val Ala 85 90 95 Phe Ala Phe Thr Thr Leu Leu Ile Ala Cys Leu Leu Leu Arg Val Phe 100 105 110 Arg Ser Gly Lys Arg Leu Lys Lys Thr Arg Lys Tyr Asp Ile Ile Thr 115 120 125 Thr Pro Ala Glu Arg Val Glu Met Ala Pro Leu Asn Glu Glu Asp Asp 130 135 140 Glu Asp Glu Asp Ser Thr Val Phe Asp Ile Lys Tyr Arg 145 150 155 <210> 349 <211> 2646 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (27)..(602) <400> 349 acgggtgctg cgcctagctg cgcacc atg gcc ggg ttg ctg gcg ttg ctg ggt 53 Met Ala Gly Leu Leu Ala Leu Leu Gly 1 5 ccg gca ggc agg gtg ggc gcc cgg gtc cgg cct cgc gcc acc tgg ctc 101 Pro Ala Gly Arg Val Gly Ala Arg Val Arg Pro Arg Ala Thr Trp Leu 10 15 20 25 ctg ggc gcc acc gcc ccc tgc gcc ccg ccg ccc ctg gcc ctg gcc ctg 149 Leu Gly Ala Thr Ala Pro Cys Ala Pro Pro Pro Leu Ala Leu Ala Leu 30 35 40 ctc ccg ccc agg cta gac gcc cgg ctg ctc cgc acg gcg cgc ggg gac 197 Leu Pro Pro Arg Leu Asp Ala Arg Leu Leu Arg Thr Ala Arg Gly Asp 45 50 55 tgc cgc ggc cac cag gac ccc agc cag gcc acg ggg aca aca ggc agc 245 Cys Arg Gly His Gln Asp Pro Ser Gln Ala Thr Gly Thr Thr Gly Ser 60 65 70 agc gtc agc tgc aca gag gag aaa aag caa agc aag tca cag caa ctg 293 Ser Val Ser Cys Thr Glu Glu Lys Lys Gln Ser Lys Ser Gln Gln Leu 75 80 85 aaa aag att ttt caa gag tat ggc act gtt ggc gtg tca ttg cac att 341 Lys Lys Ile Phe Gln Glu Tyr Gly Thr Val Gly Val Ser Leu His Ile 90 95 100 105 gga atc tca tta att tcc ttg ggc ata ttt tac atg gtt gtg tca agt 389 Gly Ile Ser Leu Ile Ser Leu Gly Ile Phe Tyr Met Val Val Ser Ser 110 115 120 ggt gtg gac atg cct gca atc ctg ctg aaa ctc gga ttt aaa gag tcc 437 Gly Val Asp Met Pro Ala Ile Leu Leu Lys Leu Gly Phe Lys Glu Ser 125 130 135 ctg gta cag tca aaa atg gca gca ggc aca agt acc ttc gtg gtg gcc 485 Leu Val Gln Ser Lys Met Ala Ala Gly Thr Ser Thr Phe Val Val Ala 140 145 150 tat gca atc cac aag ctg ttt gcg cca gtg aga atc agc att acg cta 533 Tyr Ala Ile His Lys Leu Phe Ala Pro Val Arg Ile Ser Ile Thr Leu 155 160 165 gtc tct gtg ccc ttg att gtc aga tat ttt cga aaa gtg gga ttt ttt 581 Val Ser Val Pro Leu Ile Val Arg Tyr Phe Arg Lys Val Gly Phe Phe 170 175 180 185 aaa cct cca gct gca aaa cct taatgaactc ttcagtcgta cacactgaaa 632 Lys Pro Pro Ala Ala Lys Pro 190 acctatttct tctaaattac atgatttgga ttggttttag ggttttaggg ttgtagggtt 692 tcttttggag aggtaggggg ctaattgcta tgttctcatg gataaacttt gccagcaaaa 752 atcaggcttt tgaacaattt taattttttg cctcataaat tttgtgaatg ctattcatta 812 tagggcttgt atatataatc taaaatgtca gcaaggcatc ggagatgggt taacatctca 872 aaacaaaata gcctacaaat gttccttgtg ggagactttg gcgagggtct gtgggtaaaa 932 gcaccagggg gttaatcttg gctcagtttc ctaaaaagca ttgattaatt taactggctt 992 ttaaatatcc ccttccgctg atatttgttg tcagctgcct acagtttaat atgcagcgtt 1052 cacaaaacag ctgccagtgc tacaattaat gaagcaaaac ttaatatgta atcacaatct 1112 aaattagcat caatactttg acattcatta cattggtttg ggggaagaaa agtagttctg 1172 gtatgtttca ttgatcccca gataccttcc aatctggaca tgatggggct gattccagat 1232 ggtttttctg aaatttcatt aaggtaggtc agcgtcattt gtctctgttt aggtaaaata 1292 taaaaaccct gcccagtagc agtggcatcg cttggttcct gatgcccatg ttccagagga 1352 attcggatac cacaaacagc taagacaatc tcagcttttc ttagacaatc ttctatctca 1412 aacttcagac attccagaat tgtcatgatg tttacactgt ctgagttaaa aatcctgttc 1472 aagaaaaaaa aagattttgt atcacttctt aaaaaggaat attcatagca cttgtcacaa 1532 atagaaggca accatgagat aatacaagcc agggagaggc ttgtattaca tgacaggtgt 1592 aattagtctg ctgagccagc tttacccaat gaagggcata tgtgttagag agattagcta 1652 agagtagaaa ttcgagcata gaggccaggt gcggtggctc acgcctgtaa tcccagcact 1712 ttgggaggtt gaggcaggcg tgtcacttga ggccaggagt tcgagaccag cctggccaac 1772 atgatgaaac cccgtctcta ctacaaatac aaaaattagc cgggtgtggt ggcacacgcc 1832 tgtagtccca gctactgggg aggctgaggc agcattgctt gaacccagga ggtggaggtt 1892 gcagtgagcc aagatcacac cactgcactc cagcctgggc gacagaggga gacactgtct 1952 ccaaaagaaa gaaatcccag cgtagatcca aactgagaca ctgaggcttc gtccttatag 2012 tagtcaggag caggcgattg aagtaattct gtcctgcggg gttcagcatc atgcacgttc 2072 cccctgggcc attctctgat gcagggcact tgctccacct ctgggaaccc agattcacca 2132 gtctgccctg tcacgtagtt gaaggagttg gatttatctt tctggctcct aattccttta 2192 aaattacatt tgttgcagaa cctccacaag gctaaataaa attacatttg tgaccatcag 2252 agaactgaat aaaccattaa ctggccatcc tggttttgca gagatcaggt tgttgacagt 2312 tcctggttga cccacagcta cccatgtcag ttatctccac taacatatcc aagaatcttt 2372 gtaggacaat ttctccacct gcaaggtctt tcaggtagaa ctcttctttt aaggcaatta 2432 gcccattgcc aaaaggtttt actgtcttaa agctgtcttt ctgagatcta attccaagga 2492 cttctccaca gctaagtgag atgcctcaca ccattaggtg atgctttgga cagaacagag 2552 tattttcatc ttgtgtttaa agcaattcct tggcttcggc tcctcaccac tttctatgcc 2612 agtctcccat ttatgtccct agtaatgcct atgc 2646 <210> 350 <211> 192 <212> PRT <213> Homo sapiens <400> 350 Met Ala Gly Leu Leu Ala Leu Leu Gly Pro Ala Gly Arg Val Gly Ala 1 5 10 15 Arg Val Arg Pro Arg Ala Thr Trp Leu Leu Gly Ala Thr Ala Pro Cys 20 25 30 Ala Pro Pro Pro Leu Ala Leu Ala Leu Leu Pro Pro Arg Leu Asp Ala 35 40 45 Arg Leu Leu Arg Thr Ala Arg Gly Asp Cys Arg Gly His Gln Asp Pro 50 55 60 Ser Gln Ala Thr Gly Thr Thr Gly Ser Ser Val Ser Cys Thr Glu Glu 65 70 75 80 Lys Lys Gln Ser Lys Ser Gln Gln Leu Lys Lys Ile Phe Gln Glu Tyr 85 90 95 Gly Thr Val Gly Val Ser Leu His Ile Gly Ile Ser Leu Ile Ser Leu 100 105 110 Gly Ile Phe Tyr Met Val Val Ser Ser Gly Val Asp Met Pro Ala Ile 115 120 125 Leu Leu Lys Leu Gly Phe Lys Glu Ser Leu Val Gln Ser Lys Met Ala 130 135 140 Ala Gly Thr Ser Thr Phe Val Val Ala Tyr Ala Ile His Lys Leu Phe 145 150 155 160 Ala Pro Val Arg Ile Ser Ile Thr Leu Val Ser Val Pro Leu Ile Val 165 170 175 Arg Tyr Phe Arg Lys Val Gly Phe Phe Lys Pro Pro Ala Ala Lys Pro 180 185 190 <210> 351 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 351 tacggaagtg ttacttctgc 20 <210> 352 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 352 tgtgggaggt tttttctcta 20 <210> 353 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 353 gttttcccag tcacgac 17 <210> 354 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 354 caggaaacag ctatgac 17 <210> 355 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 355 ttcccttatc tccttcgcag 20 <210> 356 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 356 ttcttggtag ggtactcaga 20 <210> 357 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 357 tcaaaaagcc ccacaagaga 20 <210> 358 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 358 ctcattgccc caaatcagta 20 <210> 359 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 359 gcctctggat ggaatgtgc 19 <210> 360 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 360 tgactttggg aggttgacca 20 <210> 361 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 361 catgtacact gtgaccagtc 20 <210> 362 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 362 cctttggctt catgagtgaa 20 <210> 363 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 363 cccagtatca ggtgtgtatt 20 <210> 364 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 364 gggttcctga aaactggtat 20 <210> 365 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: an artificially synthesized primer sequence <400> 365 tcctgtggca tccacgaaac t 21 <210> 366 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: an artificially synthesized primer sequence <400> 366 gaagcatttg cggtggacga t 21 <210> 367 <211> 808 <212> DNA <213> Homo sapiens <400> 367 tctcctcctg cacacctccc tcgctctccc acaccactgg caccaggccc cggacacccg 60 ctctgctgca ggagaatggc tactcatcac acgctgtgga tgggactggc cctgctgggg 120 gtgctgggcg acctgcaggc agcaccggag gcccaggtct ccgtgcagcc caacttccag 180 caggacaagt tcctggggcg ctggttcagc gcgggcctcg cctccaactc gagctggctc 240 cgggagaaga aggcggcgtt gtccatgtgc aagtctgtgg tggcccctgc cacggatggt 300 ggcctcaacc tgacctccac cttcctcagg aaaaaccagt gtgagacccg aaccatgctg 360 ctgcagcccg cggggtccct cggctcctac agctaccgga gtccccactg gggcagcacc 420 tactccgtgt cagtggtgga gaccgactac gaccagtacg cgctgctgta cagccagggc 480 agcaagggcc ctggcgagga cttccgcatg gccaccctct acagccgaac ccagaccccc 540 agggctgagt taaaggagaa attcaccgcc ttctgcaagg cccagggctt cacagaggat 600 accattgtct tcctgcccca aaccgataag tgcatgacgg aacaatagga ctccccaggg 660 ctgaagctgg gatcccggcc agccaggtga cccccacgct ctggatgtct ctgctctgtt 720 ccttccccga gcccctgccc cggctccccg ccaaagcacc cctgcccact cgggcttcat 780 cctgcacaat aaactccgga agcaagtc 808 <210> 368 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 368 aacttccagc aggacaagtt 20 <210> 369 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence:an artificially synthesized primer sequence <400> 369 aggaacagag cagagaca 18 <210> 370 <211> 688 <212> DNA <213> Homo sapiens <400> 370 cgaagggtac cgacccggca gaagctcgga gctctcgggg tatcgaggan gcaggcccgc 60 gggcgcacgg gcgaacgggc cgggagccgg agcggcggag gagccggcag cagcggcgcg 120 gcgggctcca ggcgaggcgg tcgacgctcc tgaaaacttg cgcgcacgct cgcgccactg 180 cgcccggagc gatgaanatg gtcgcgccct ggacgcggtt ctactccaac agctgctgct 240 tgtgctgcca tgtccgcacc ggcaccatcc tgctcggcgt ctggtatctg atcatcaatg 300 ctgtggtact gttgatttta ttgagtgccc tggctgatcc ggatcagtat aacttttcaa 360 gttctgaact gggaggtgac tttgagttca tggatgatgc cnacatgtgc attgccattg 420 cgatttctct tctcatgatc ctgatatgtg ctatggctac ttacggagcg tncaancaac 480 gcgcagcctg gatcatccca ttcttctgtt accagatctt tgactttgcc ctgaacatgt 540 tggttgcaat cactgtgctt atttatccaa actccnttca ggaatacata cngcaactgc 600 ctcctaattt tccctacana natcatgtcn tgtccgtgaa tccctacctg tttggtccct 660 attattcctc tgttttattt accnttaa 688 <210> 371 <211> 603 <212> DNA <213> Homo sapiens <400> 371 aggcgtaata atagagaagg tgccagaaag accaaaacaa gtggctgcgg ccgtcgccca 60 ggagtcatcg gacgccagaa tctggccggg ttctgagctt gttccgcctc cctcccccgg 120 gaatggcgct atccgggtcg accccggccc cgtgctggga ggaggatgag tgcctggact 180 actacgggat gctgtcgctt caccgtatgt tcgaggtggt gggcgggcaa ctgaccgagt 240 gcgagctgga gctcctggcc tttctgctgg atgaggctcc tggcgccgcc ggaggcttan 300 cccgggcccg cagcggccta nagctcctgc tggagctgga gcgccgcggg cagtgcggcg 360 anagcaacct gcggctgctg gggcaactcc tgcgcgtgct ggcccgccac gacctgctgc 420 cgcacctggc gcgcaagcgg cgccgggcan ttgtctccaa aaacgctata nctatggcac 480 ctccagctct tccaaagaag gacagaaggg ttancttgcc cgtccccgtc ngcagtcaan 540 caattcttgc aaattcctca ancaagggtc agttgggaan acaaggctcc ccccccaacc 600 aaa 603 <210> 372 <211> 777 <212> DNA <213> Homo sapiens <400> 372 acactcggcc taggaattcc cttatctcct tcgcagtgca gctccttcaa cctcgccatg 60 gcctctgccg gaatgcagat cctgggagtc gtcctgacac tgctgggctg ggtgaatggc 120 ctggtctcct gtgccctgcc catgtggaag gtgaccgctt tcatcggcaa cagcatcgtg 180 gtggcccagg tggtgtggga gggcctgtgg atgtcctgcg tggtgcagag caccggccag 240 atgcagtgca aggtgtacga ctcactgctg gcgctgccac aggacctgca ggctgcacgt 300 gccctctgtg tcatcgccct ccttgtggcc ctgttcggct tgctggtcta ccttgctggg 360 gccaagtgta ccacctgtgt ggaaganaag gattccaagg cccgcctggt gctcacctct 420 gggattgtct ttgtcatctc aggggtcctg acgctaatcc ccgtgttgct ggacggcgca 480 tgccgtcatc cgggacttct ataaccccct ggtggctgan gcccaaaagc gggagctggg 540 ggcctccctc tacttgggct gggcggcctc aggccttttg tttgctgggg ttgggggggt 600 tgcttgtgct gcacttgccc ctccgggggg gggtccccaa ggggccccan ccattaacat 660 tgggccccgc ttactccaaa caatcttgcc ccttgccaat ctctccgggg ggggncctct 720 tgaaatttac ccctaaccca aanaaattta acnttcttgn aacnttggga aaggggg 777 <210> 373 <211> 461 <212> DNA <213> Homo sapiens <400> 373 gagacggggt ggcggctgca gccgggtagg gccaggagac cggtccacgt ttgcaaacgc 60 agccgaacgc ccaggccgac ccgtgccgcc cgagcgccgc gctgcgtccg cgccactctt 120 ctcgccgccc cgatggcgtt ccggggctgg aggcccccgc cgccaccgct gctcctgctg 180 ctgctctggg tgaccgggca ggcagcgccc gtggcgggcc tgggctccga cgcggagctg 240 cagatcgagc ggcgcttcgt gcccgacgag tgcccgcgca ccgtgcgcag cggcgacttc 300 gtgcgctacc actacgtggg gacgttcccc gacggccana agttcgactc cagctatgac 360 agaaactcca ctttcaatgt gtttgtggga aaaggacagc tgatcacagg gatggaccan 420 gctcttgttt ggggatgttc gttnaacnaa aanacntttc c 461 <210> 374 <211> 699 <212> DNA <213> Homo sapiens <400> 374 tcttccgggt ggggccccgg gccgaggcga tggcgccctg ggcgctcctc agccctgggg 60 tcctggtgcg gaccgggcac accgtgctga cctggggaat cacgctggtg ctcttcctgc 120 acgataccga gctgcggcaa tgggaggagc agggggagct gctcctgccc ctcaccttcc 180 tgctcctggt gctgggctcc ctgctgctct acctcgctgt gtcactcatg gaccctggct 240 acgtgaatgt gcagccccag cctcaggagg agctcaaaga ggagcagaca gccatggttc 300 ctccagccat ccctcttcgg cgctgcagat actgcctggt gctgcagccc ctgagggctc 360 ggcactgccg tgagtgccgc cgttgcgtcc gccgctacga ccaccactgc ccctggatgg 420 agaactgtgt gggagagcgc aaccacccac tctttgtggt ctacctggcg ctgcagctgg 480 tggtgcttct gtggggcctg tacctggcat ggtcaggcct ccggttcttc cagccctggg 540 gtctgtggtt gcggtccagc gggctcctgt tcgccacctc cttgctgctg tcccacttct 600 tctgttggna tggccctcca agggtccttg ggggaaaanc ctcctggggc tgnaaggaag 660 gaaggaaaaa agggcaagca agccccaanc tgnttttaa 699 <210> 375 <211> 575 <212> DNA <213> Homo sapiens <400> 375 gcggctgcag cgggcttgta ggtgtccggc tttgctggcc cagcaagcct gataagcatg 60 aagctcttat ctttggtggc cgtggtcggg tgtttgctgg tgcccccagc tgaagccaac 120 aagagttctg aagatatccg gtgcaaatgc atctgtccac cttatagaaa catcagtggg 180 catatttaca accagaatgt atcccagaag gactgcaact gcctgcacgt ggtggagccc 240 atgccagtgc ctggccatga cgtggaggcc tactgcctgc tgtgcgagtg caggtacgan 300 gaagcgcagc accaccacca tcaaggtcat cattgtcatc tacctgtccg tggtgggtgc 360 cctgttgctc tacatggcct tcctgatgct ggtggaccct ctgatccgaa agccggatgc 420 atacactgag caactgcaca atgaggagga gaatgaggat gctcgctcta tggcagcagc 480 tgctgcatcc ctcgggggac cccgagcaaa cacagtcctg gancgtgtgg aaagtgccca 540 ncancggtgg aactgcaggt gcaggancan cggaa 575 <210> 376 <211> 840 <212> DNA <213> Homo sapiens <400> 376 gtaaataatc tcggaaaggc gagaaagaag ctgtctccat cttgtctgta tccgctgctc 60 ttgtgacgtt gtggagatgg ggagcgtcct ggggctgtgc tccatggcga gctggatacc 120 atgtttgtgt ggaagtgccc cgtgtttgct atgccgatgc tgtcctagtg gaaacaactc 180 cactgtaact agattgatct atgcactttt cttgcttgtt ggagtatgtg tagcttgtgt 240 aatgttgata ccaggaatgg aagaacaact gaataagatt cctggatttt gtgagaatga 300 gaaaggtgtt gtcccttgta acattttggt tggctataaa gctgtatatc gtttgtgctt 360 tggtttggct atgtcctatc ttcttctctc tttactaatg atcaaagtga agagtagcag 420 tgatcctaga gctgcagtgc acaatggatt ttggttcttt aaatttgctg cagcaattgc 480 aattattatt ggggcattct tcattccaga aggaactttt acaactgtgt ggttttatgt 540 angcatggca ggtgcctttt gtttcatcct catacaacta ntcttactta ttgattttgc 600 acattcatgg aatgaatcct gggttgaaaa aatggaagaa aggaactcca aaatgttggt 660 atgcancctt gttatcagct acagctctga attatctgct gtctttaatt gctatcgtcc 720 tgttccttgt ctactacact cntcccaccc atttgttcca aaaaacaagg ggttccacca 780 ntgtcnacat gcnccnccgc ctttggggcc tccgttatgt tcaaactgcc caaaatccca 840 <210> 377 <211> 785 <212> DNA <213> Homo sapiens <400> 377 ggcgttcctt cgccgccgcc aggggtagcg gtgtagctgc gcagcgtcgc gcgcgctacc 60 gcacccaggt tcggcccgta ggcgtctggc agcccggcgc catcttcatc gagcgccatg 120 gccgcagcct gcgggccggg agcggccggg tactgcttgc tcctcggctt gcatttgttt 180 ctgctgaccg cgggccctgc cctgggctgg aacgaccctg acagaatgtt gctgcgggat 240 gtaaaanctc ttaccctcca ctatgaccgc tataccacct cccgcaggct ggatcccatc 300 ccacagttga aatgtgttgg aggcacagct ggttgtgatt cttatacccc aaaagtcata 360 cagtgtcaga acaaaggctg ggatgggtat gatgtacant gggaatgtaa gacggactta 420 natattgcat acaaatttgg aaaaactgtg gtgagctgtg aangctatga ntcctctgaa 480 gaccagtatg tactaagaag ttcttgtggc ttggantata atttanatta tacagaactt 540 ggcctgcagg aactgaagga ntctggaaag cagcacggct ttgcctcttt ctctgattat 600 tattataagt ggtcctcggc ggattcctgt aacatgaatg gattgattac catcgtggta 660 ctccttggga tccctttgta tctataanct gtttcctgaa ttgacgggca agtattctcc 720 tcccaccgta ctctgaattn tcctcccntt ttccccaccg tttaccaana aanttcacca 780 acttc 785 <210> 378 <211> 574 <212> DNA <213> Homo sapiens <400> 378 aaaaaaaaaa aaaaaaaaaa tcgctggcgg ancggctggg cggcgggccg ggcccggggc 60 cgcttggaat ggcgcctcct ccgccttcgc cccaactgct tctcctggca gccctcgcna 120 ggctcctggg tcccagcgag gtgatggctg gaccggcgga ggaggcggga gcccattgtc 180 ccgaaagcct gtggcctctg cctccgcagg tgtcaccaaa agtgacctac acacaantga 240 gcccagggca ggctgaggat gtcaccttcc tctaccaccc ctgtgcccat ccctggctga 300 agctccagct tgccctcctg gcctatgctt gtatggctaa cccttccctc acccctgact 360 tcagcctcac gcaggatcgg cccctggtgc tgactgcatg ggggctggcg ctggaaatgg 420 cctgggtaaa nccagcctgg gctgcccact ggctgatgag gaggcggagg aggaagcana 480 ggaagaanaa gcatggatct actgtgaaag cctttcaggg cctgctccct ccgagccaac 540 tcccggtaaa aggangctgt gccnaaaaag gtnt 574 <210> 379 <211> 880 <212> DNA <213> Homo sapiens <400> 379 aaataatctt gcttgaagac tgacaagatg tccctgtgga ctcccaaact ctactccaga 60 tggggaggtg cccttaacac caagatttta aaagctccaa tttcagagca agagtcgaaa 120 actcacagat aaagttatag ttatttcagg gttctgaaaa gacgcanaac atgaagggac 180 tcagaagtct ggcagcaaca accttggctc ttttcctggt gtttgttttc ctgggaaact 240 ccagctgcgc tccgcagaga ctgttggaga gaaggaactg gactcctcaa gctatgctct 300 acctgaaagg ggcacagggt cgccgcttca tctccgacca gagccggaga aaggacctct 360 ccgaccggcc actgccggaa agacgaagcc caaatcccca actactaact attccggagg 420 cagcaaccat cttactggcg tcccttcaga aatcaccaga agatgaanaa aaaaactttg 480 atcaaaccag attcctggaa gacagtctgc ttaactggtg aaaatatact ggattatgtt 540 taattatggt tctattctct ttgaaaacat gaaccatgtg aataaaacct ttgggaccct 600 tttattccat ttgtaatctt aagaacacac acagatagtt ttattctttc nnaaacaaat 660 atatatangg atgcttaact gaanaacatc atcttctttc attgcttcag gtcctgtttt 720 aaatgaacca aaatgttttc cagatcacct tgtgttctta ctccttgant ttcttaagaa 780 tatttatnat tataagggtg aaanaactaa agttgttctt tcccttttaa cttatagcca 840 gtacctgtct tgaatcttaa gtgtgttttt nnnttcccct 880 <210> 380 <211> 756 <212> DNA <213> Homo sapiens <400> 380 atgtcgccgc tgctggggct ccggtccgag ctgcaggaca cctgcacctc gctgggactg 60 atgctgtcgg tggtgctgct catggggctg gcccgcgtag tcgcccggca gcagctgcac 120 aggccggtgg cccacgcctt cgtcctggag tttctagcca ccttccagct ctgctgctgc 180 acccacgagc tgcaactgct gagcgaacag caccccgcgc accccacctg gacgctgacg 240 ctcgtctact tcttctcgct tgtgcatggc ctgactctgg tgggcacgtc cagcaacccg 300 tgcggcgtga tgatgcanat gatgctgggg ggcatgtccc ccgagacggg tgcggtgagg 360 ctattggctc anctggttag tgccctgtgc agcaggtact gcacaagcgc cttgtggagc 420 ttgggtctga cccagtatca cntcagcgag aggagcttcg cttgcaanaa tcccatccga 480 ntcgacttgc tcaaagcggt catcacagan gccgtctgct cctttctctt ccacagcgct 540 ctgctgcact tccagnaaag tccgaaccaa gcttcgtatc cacctgctgg ctgcactcca 600 tcaccttttt ggtctatgca ggaagaagtc taacangaag ctgtatttaa tcccnacttt 660 gggactttcn cctacatttc atgtnttttt gaattcaaaa cctttcccct ccagtttttt 720 atnagttatt actggggtng ggctcccttc ctttna 756 <210> 381 <211> 510 <212> DNA <213> Homo sapiens <400> 381 gannaagggt cgtnggtggg aaagatggcg gcggctctgg gaccccttgg gtcgtggcag 60 cagtggcggc gatgtttgtc ggctcgggat gggtccagga tgttactcct tcttcttttg 120 ttggggtctg ggcaggggcc acagcaagtc ggggcgggtc aaacgttcna gtacttgaaa 180 cgggagcact cgctgtcgaa gccctaccag ggtgtgggca caggcagttc ctcactgtgg 240 aatctgatgg gcaatgccat ggtgatgacc cagtatatcc gccttacccc agatatgcaa 300 agtaaacagg gtgccttgtg gaaccgggtg ccatgtttcc tgagagactg ggagttgcag 360 gtgcacttca aaatccatgg acaaggaaag aaaaatctgc atggggatgg cttggcaatc 420 tggtacacaa angatcggat gcagccangg cctgtgtttg gaaacatgga caaatttgtg 480 gggctgggan tatttgtnna cacctacccc 510 <210> 382 <211> 938 <212> DNA <213> Homo sapiens <400> 382 agttcctcct tgctctcgcc cctactcttt ctggtgttag atcgagcaac cctctaaaag 60 cagtttagag tggtaaaaaa aaaaaaaaca caccaaacgc tcgcagccac aaaagggatg 120 aaatttcttc tggacatcct cctgcttctc ccgttactga tcgtctgctc cctaaagtcc 180 ttcgtgaagc tttttattcc taagaggana aaatcagtca ccggcgaaac cgtgctgatt 240 acaggagctg ggcatggaat tggganactg actgcctatg aatttgctaa acttaaaagc 300 aagctggttc tctgggatat aaataagcat ggactggagg aaacagctgc caaatgcaag 360 ggactgggtg ccaaggttca tacctttgtg gtanactgca gcaaccgana anatatttac 420 agctctgcaa agaaggtgaa ggcagaaatt ggagatgtta gtattttagt aaataatgct 480 ggtgtagtct atacatcaga tttgtttgct acacaagatc ctcagattga aaagactttt 540 gaagttaatg tacttgcaca tttctggact acaaaggcat ttcttcctgc aatgacnaan 600 aataaccatg gccatattgt cactgtggct tcggcagctg gacatgtctc ggtccccttc 660 ttactggctt actgttcaag caaatttgct gctgttggga tttcataaaa ctttgacaga 720 tgaactggct gccttacaaa taactgggan tcaaaacaac atttctgttg tcctaaattt 780 tcgtaaaaca ctggcttcca tccaaaaaat cccaatttcc aatttttggg gaaccccnct 840 cctgggaaac ctgaaagnaa attggttaaa acaaggcttg aatgccttng ggaattcctg 900 aactggaacc naaaaaaaaa aaatttttta nttccccn 938 <210> 383 <211> 862 <212> DNA <213> Homo sapiens <400> 383 gaattgcggc cgtatgcgcg gctctgtgga gtgcacctgg ggttgggggc actgtgcccc 60 cagccccctg ctcctttgga ctctacttct gtttgcancc ccatttggcc tgctggggga 120 aaanacccgc caggtgtctc tggaggtcat ccctaactgg ctgggccccc tgcagaacct 180 gcttcatata cgggcagtgg gcaccaattc cacactgcac tatgtgtgga gcagcctggg 240 gcctctggca gtggtaatgg tggccaccaa caccccccac agcaccctga gcgtcaactg 300 gagcctcctg ctatcccctg agcccgatgg gggcctgatg gtgctcccta aggacagcat 360 tcagttttct tctgcccttg tttttaccag gctgcttgag tttgacagca ccaacgtgtc 420 cgatacggca gcaaagcctt tgggaagacc atatcctcca tactccttgg ccgatttctc 480 ttggaacaac atcactgatt cattggatcc tgccaccctg antgccacat ttcaaggcca 540 ccccatgaac gaccctacca ggacttttgc caatggcagc ctggccttca aggtccaagg 600 ccttttccan gtccagccga acaagcccaa ccccctcgcc tcctgcacac agcananacc 660 tgtcagctaa aagtggccct gattggancc tctccccggg ggaaaccgtt ccctgttttg 720 gggcttggaa ggttacccac atttggggcc aagggccctg aactgcccct ccnattgcca 780 ggaaacaacc nctcccatcc caacaaataa atattccncc gggccgtctt cccaatttgg 840 gaaccancct actgtngggg gg 862 <210> 384 <211> 671 <212> DNA <213> Homo sapiens <400> 384 atcctgagtt gtttaggact ttctattgtg gcaaacttcc agaaaacaac cctttttgct 60 gcacatgtaa gtggagctgt gcttaccttt ggtatgggct cattatatat gtttgttcag 120 accatccttt cctaccaaat gcagcccaaa atccatggca aacaagtctt ctggatcaga 180 ctgttgttgg ttatctggtg tggagtaagt gcacttagca tgctgacttg ctcatcagtt 240 ttgcacagtg gcaattttgg gactgattta gaacagaaac tccattggaa ccccgaggac 300 aaaggttatg tgcttcacat gatcactact gcagcagaat ggtctatgtc attttccttc 360 tttggttttt tcctgactta cattcgtgat tttcagaaaa tttctttacg ggtggaagcc 420 aatttacatg gattaaccct ctatgacact gcaccttgcc ctattaacaa tgaacgaaca 480 cggctacttt ccagagatat ttgatgaaag gataaaatat ttctgtaatg attatgattc 540 tcanggattg gggaaaggtt cacagaaatt gcttattttt ctctgaaatt ttcaaccact 600 taatcaaggn tgacagtnac nctgatgaat gctgataaat cacgaaaaca tgaaaagaan 660 ccatttgant a 671 <210> 385 <211> 727 <212> DNA <213> Homo sapiens <400> 385 ctactctggc accactctcc aggctgccat ggggcccagc acccctctcc tcatcttgtt 60 ccttttgtca tggtcgggac ccctccaagg acagcagcac caccttgtgg agtacatgga 120 acgccgacta gctgctttag aggaacggct ggcccagtgc caggaccaga gtagtcggca 180 tgctgctgag ctgcgggact tcaagaacaa gatgctgcca ctgctggagg tggcaganaa 240 ggagcgggag gcactcagaa ctgaggccga caccatctcc gggagagtgg atcgtctgga 300 gcgggaggta gactatctgg agacccagaa cccagctctg ccctgtgtan agtttgatga 360 gaaggtgact ggaggccctg ggaccaaagg caagggaaga aggaatgaga agtacgatat 420 ggtgacagac tgtggctaca caatctctca agtgagatca atgaagattc tgaagcgatt 480 tggtggccca gctggtctat ggaccaagga tccactgggg caaacagana agatctacnt 540 gttanatggg acacanaatg acacagcctt tgtcttccca aggctgcgtg acttcaccct 600 tgccatggct gcccggaaag cttcccgant ccgggtgcct tcccctgggt tagcacangg 660 canctggtat atggtggctt tctttatttt gctccgaagn ctcctggaaa aactggttgg 720 aagtngt 727 <210> 386 <211> 732 <212> DNA <213> Homo sapiens <400> 386 accgagttgt cttttgacat gtggggactc gtcagcgccc tcgccgccac gctgtgcttc 60 tcgcttcaga acattttctc caaaaaggtc ttgcgagatt cacggatcca ccatctccgg 120 ctgctcaaca tcctgggctg ccacgccgtc ttctttatga tccccacctg ggttctggtg 180 gacctctcgg ctttcctggt cagcagcgac ttgacctacg tctaccagtg gccctggacg 240 ctcctgctcc tggctgtcag cggcttctgt aactttgccc agaatgttat cgccttcagc 300 atcctcaacc tcgttagccc cctgagctac tcggtcgcca atgccaccaa aagaatcatg 360 gtcatcacgg tgtccctgat catgctgcgc aacccagtca ccagcaccat cgtcctgggc 420 atgatgaccg ccatcctggg ggtcttcctc tataacaaga ccaagtacga tgcaaaccag 480 caagccagga agcacctcct ccccgtcacc acagcagacc tgancagcaa ggagcgtcac 540 cggagcccac tggagaancc ccacaacggg ctcctcttcc cccagcacgg ggantatcag 600 tacgggcgca acaacatctt aacagaacac ttccaataca gccggnagan ctacccaact 660 cgtacagttt gaaccgctat gatgtgtana ntccaanagg acaggaacag actgttgggt 720 gaatccttcc cc 732 <210> 387 <211> 518 <212> DNA <213> Homo sapiens <400> 387 cctcctcccc tctgccctgt gctgaccagg gcctgggagc ccccgcacgg ttcagacaga 60 ggggccaggc tgaagctgga gaggaaccag cgtcacacag acggcctctg agaacttgga 120 gaccccgtta cccacccagc aggggtgtca ggacaagcat ctgctgcagg cttcagcctc 180 aggggcaaaa gggagccccg gggtcctggt gggggcaccg accacaggcc cggagggtgg 240 atgcctgcag gaagctgggc tctgtggagc ccgaggaggg gctggtggcc acaccccccg 300 gccccctggc tcggcggccc tcatgcccgc cctacgtcca ctcctgccgc tcctgctcct 360 cctccggctg acctcggggg ctggcttgct gccagggctg ggganccacc cgggcgtgtg 420 ccccaaccan ctcagcccca acctgtgggt ggacgcccag agcacctgtg ancgcgagtg 480 tancagggac cangactgtg cggctgctga aaantgct 518 <210> 388 <211> 746 <212> DNA <213> Homo sapiens <400> 388 acgtcggacc cggaggccct gaatgcccca tgcgcacccc acagctcgcg ctcctgcaag 60 tgttctttct ggtgttcccc gatggcgtcc ggcctcagcc ctcttcctcc ccatcagagg 120 cagtgcccac gtctttggag ctgcagcgag ggacggatgg cggaaccctc cagtcccctt 180 cagaggcgac tgcaactcgc ccggccgtgc ctggactccc tacagtggtc cctactctcg 240 tgactccctc ggcccctggg aataggactg tggacctctt cccagtctta ccgatctgtg 300 tctgtgactt gactcctgga gcctgcgata taaattgctg ctgcgacagg gactgctatc 360 ttctccatcc gaggacagtt ttctccttct gccttccagg cagcgtaagg tcttcaagct 420 gggtttgtgt agacaactct gttatcttca ggagtaattc cccgtttcct tcaagagttt 480 tcatggattc taatggaatc aggcagtttt gtgtccatgt gaacaactca aacttaaact 540 atttccagaa gcttcaaaag gtcaatgcaa ccaacttcca ngccctggct gcanantttg 600 ggaggcgaat cattcacttc aacattccaa acacaatcac caccatcttt ttacaagggg 660 tggggaccca ttcttactta cttccccnag tggtctgttt ataanctttg ctgaanacaa 720 cctgccagna attggaactn ggggga 746 <210> 389 <211> 726 <212> DNA <213> Homo sapiens <400> 389 gttacggccg aaaagatggc ggtcttggca cctctaattg ctctcgtgta ttcggtgccg 60 cgactttcac gatggctcgc ccaaccttac taccttctgt cggccctgct ctctgctgcc 120 ttcctactcg tgaggaaact gccgccgctc tgccacggtc tgcccaccca acgcgaagac 180 ggtaacccgt gtgactttga ctggagagaa gtggagatcc tgatgtttct cagtgccatt 240 gtgatgatga agaaccgcag atccatcact gtggagcaac atataggcaa cattttcatg 300 tttagtaaag tggccaacac aattcttttc ttccgcttgg atattcgcat gggcctactt 360 tacatcacac tctgcatagt gttcctgatg acgtgcaaac cccccctata tatgggccct 420 gagtatatca agtacttcaa tgatnaaacc attgatgagg aactagaacg ggacaagaag 480 gtcacttgga ttgtggagtt ctttgccaat tggtctaatg actgccaatc atttgcccct 540 atctatgctg acctctccct taaatacaac tgtacagggc taaattttgg gaangtggat 600 gttngacgct atactgatgt tagtacgcgg tacaaaatga gcacatcacc cctcaccaag 660 caactcccta ccctgatnct gttccaaggt ggcaaggaag caatgcngcn ggccccnnat 720 tgacaa 726 <210> 390 <211> 528 <212> DNA <213> Homo sapiens <400> 390 aaaacttccg gtgcctgcag agctcggagc ggcggaggca ganaccgagg ctgcaccggc 60 agangctgcg gggcggacgc gcgggccggc gcagccatgg tgaagattag cttccagccc 120 gccgtggctg gcatcaaggg cgacaaggct gacaaggcgt cggcgtcggc ccctgcgccg 180 gcctcggcca ccgagatcct gctgacgccg gctagggagg ancagccccc acaacatcga 240 tccaagaggg ggggctcant gggcggcgtg tgctacctgt cgatgggcat ggtcgtgctg 300 ctcatgggcc tcgtgttcgc ctctgtctac atctacagat acttcttcct tgcgcagctg 360 gcccganata acttcttccg ctgtggtgtg ctgtatgagg actccctgtc ctcccaggtc 420 cggactcaga tggagctgga agangatgtg aaaatctacc tcgacnanaa ctacnagcgc 480 atcaacgtnc ctgtgcccca gtttggcggc ggtgaccctg cagacatc 528 <210> 391 <211> 739 <212> DNA <213> Homo sapiens <400> 391 actcggctgt gcggcggggc aggcatggga gccgcgcgct ctctcccggc gcccacacct 60 gtctgagcgg cgcagcgagc cgcggcccgg gcgggctgct cggcgcggaa cagtgctcgg 120 catggcaggg attccagggc tcctcttcct tctcttcttt ctgctctgtg ctgttgggca 180 agtgagccct tacagtgccc cctggaaacc cacttggcct gcataccgcc tccctgtcgt 240 cttgccccag tctaccctca atttagccaa gccagacttt ggagccgaag ccaaattaga 300 agtatcttct tcatgtggac cccagtgtca taagggaact ccactgccca cttacgaaga 360 ggccaagcaa tatctgtctt atgaaacgct ctatgccaat ggcagccgca cagagacgca 420 ggtgggcatc tacatcctca gcagtagtgg agatggggcc caacaccgag actcagggtc 480 ttcaggaaag tctcgaaaga agcggcagat ttatggctat gacagcaggt tcagcatttt 540 tgggaaagac ttcctgctca actacccttt ctcaacatca gtgaagttat ccacgggctg 600 cacggcaccc tggtggcana aaaacatgtc ctcacagctt gcccactgca tacaccgatg 660 gaaaaaccta ttttnaaagg aanccaaaaa actttccaat ngggcttcct aaaagcccaa 720 ntttaaaaaa tngtgggtc 739 <210> 392 <211> 793 <212> DNA <213> Homo sapiens <400> 392 gctgctgccg ccgccgcctc gggtcgtgga gccaggagcg acgtcaccgc catggcaggc 60 atcaaagctt tgattagttt gtcctttgga ggagcaatcg gactgatgtt tttgatgctt 120 ggatgtgccc ttccaatata caacaaatac tggcccctct ttgttctatt tttttacatc 180 ctttcaccta ttccatactg catagcaaga agattagtgg atgatacaga tgctntgagt 240 aacgcttgta aggaacttgc catctttctt acaacgggca ttgtcgtgtc agcttttgga 300 ctccctattg tatttgccag agcacatctg attgagtggg gagcttgtgc acttgttctc 360 acaggaaaca cantcatctt tgcaactata ctaggctttt tcttggtctt tggaagcaat 420 gacgacttca gctggcagca gtggtgaaaa naaattactg aactattgtc aaatggactt 480 cctgtcattt gttggccatt cacgcacaca ggganatggg gcagttaatg ctgaatggta 540 tngcaagcct cttgggggta ttttaagtgc tcccttctca cttttattgt tagcatacta 600 ttttcaccna gacttgctga anggattnaa aagatttctc ttttgggaaa aacttgactg 660 atttcncact tatctataat tatgnctttt tgtggtgttc cgctgaattt taaatattta 720 tgtntttttn ccccgtttaa ggttgaattt ttttttggga aaccaatatn ccnatgtttt 780 aaccnctttt ttt 793 <210> 393 <211> 783 <212> DNA <213> Homo sapiens <400> 393 tttactcttg cattcttccc agcaacaata tggctttttc ttcagctttt atcaatcaca 60 cccatcaacg aatggctttt aaaaggtttg cagacagtag gttgcatgcc tccgcctgtg 120 tcttctgcag tgattttaac caaggcagtt ggtggaaatg aggcagctgc aatatttaat 180 tcagcctttg gaagtttttt gggcatcgtt ataacacccc tgctcctgct gctttttctt 240 ggttcatctt cttctgtgcc tttcacatct attttttctc agctttttat gactgttgtg 300 gttcctctca tcattggaca gattgtccga agatacatca aggattggct tgaganaaag 360 aagcctcctt ttggtgctat cagcagcagt gtactcctca tgatcatcta cacaacattc 420 tgtgacacgt tctctaaccc aaatattgac ctggataaat tcagccttgt tctcatactg 480 ttcataatat tttctatcca gctgantttt atgcttttaa ctttcatctt ttcaacaagg 540 aataattcgg gtttcacacc agcagacaca gtggctatca ttttctgttc tacacacaaa 600 tcccttacat tggggaattc cgatgctgaa aaatcttgtt tgcaaggcca tgaattatct 660 ctctttaata tctgttaccc ttgctcatct acccacccaa nctcaaaatt cttcctgggg 720 aaantnttnt ttgggtncca acaaatccaa attcttggga attggttttc caagggcaaa 780 aaa 783 <210> 394 <211> 602 <212> DNA <213> Homo sapiens <400> 394 ttgcgacgtc gaggcgctca tggttgcagg cgggcgccgc cgttcagttc agggtctgag 60 cctggaggag tgagccaggc agtgagactg gctcgggcgg gccgggacgc gtcgttgcag 120 cagcggctcc cagctcccag ccaggattcc gcgcgcccct tcacgcgccc tgctcctgaa 180 cttcagctcc tgcacagtcc tccccaccgc aaggctcaag gcgccgccgg cgtggaccgc 240 gcacggcctc taggtctcct cgccaggaca gcaacctctc ccctggccct catgggcacc 300 gtcagctcca ggcggtcctg gtggccgctg ccactgctgc tgctgctgct gctgctcctg 360 ggtcccgcgg gcgcccgtgc gcangaggac gangacggcg actacgaaga gctggtgcta 420 gccttgcgtt ccgangaaga cggcctggcc gaancacccg agcacggaac cacagccacc 480 ttccaccgct gcgccaanga tccgtggang ttgcctggca cctacgtggt ggtgctgaaa 540 gaagaaacca cctctcgcan tcagaacgca ctgcccgccg cctgcangcc cangctgccn 600 cc 602 <210> 395 <211> 550 <212> DNA <213> Homo sapiens <400> 395 gagcgagcga gcgagcgagt tgccgagcgc gcccccgtcc ctcgcgcgcg atgctcccct 60 ggacggcgct cggcctggcc ctgagcttgc ggctggcgct ggcgcggagc ggcgcggagc 120 gcggtccacc agcatcggcc ccccgagggg acctgatgtt cctgctggac agctcagcca 180 gcgtctctca ctacganttc tcccgggttc gggagtttgt ggggcaactg gtggctccac 240 tgcccctggg caccggggcc ctgcgtgcca gtctggtgca cgtgggcagt cggccataca 300 ccgagttccc cttcggccag cacanctcgg gtgaggctgc ccaggatgcg gtgcgtgctt 360 ctgcccancg catgggtgac acccacactg gcctggcgct ggtctatgcc aaggaacagc 420 tgtttgctga ancatcaggt gcccggccag gggtgcccaa agtgctggtg tgggtgacan 480 atggcgggtc cnccgaccct gtgggccccc ccatgcacga nctcaaggac ctgggcntca 540 ccgtgtncat 550 <210> 396 <211> 686 <212> DNA <213> Homo sapiens <400> 396 ccagtgagag cggctttcca ggacggtgcg atgtgctgcg cagcgaanan gcaggaggcc 60 ggcttcctgg ggtagcggta caggcgggcg cttactctgt gcgcttgctt ccccaaccct 120 gcaccggcca tgcgcccggc cttggcggtg ggcctggtgt tcgcaggctg ctgcagtaac 180 gtgatcttcc tagagctcct ggcccggaag catccaggat gtgggaacat tgtgacattt 240 gcacaatttt tatttattgc tgtggaaggc ttcctctttg aagctgattt gggaaggaag 300 ccaccagcta tcccaataag gtactatgcc ataatggtga ccatgttctt caccgtgagc 360 gtggtgaaca actatgccct gaatctcaac attgccatgc ccctgcatat natatttaga 420 tccggttctc taattgccaa catgattcta ggaattatca ttttgaanaa aagatacagt 480 atattcaaat atacctccat tgccctggtg tctgtgggga tatttatttg cacttttatg 540 tcagcaaagc aggtgacttc ccagtccagc ttgagtgana atgatgggat tcccggccat 600 ttgttgtngt ggttactaag tattgggggc ntttgacttt ttgctccttc ctgatgttcn 660 nccaagggat gggggaatat tcccan 686 <210> 397 <211> 615 <212> DNA <213> Homo sapiens <400> 397 tctccctctc caggggcatc tccccctcca aggctctgca aagaactgcc ctgtcttcta 60 gatgccttct tgaggctgct tgtggccacc cacagacact tgtaaggagg anagaagtca 120 gcctggcaga nagactctga aatgagggat tagaggtgtt caaggagcaa gagcttcagc 180 ctggagacaa gggagcagtc cctgaagacg cttctactga gaggtctgcc atggcctctc 240 ttggcctcca acttgtgggc tacatcctag gccttctggg gcttttgggc acactggttg 300 ccatgctgct ccccagctgg aaaacaagtt cttatgtcgg tgccagcatt gtgacagcag 360 ttggcttctc caagggcctc tggatggaat gtgccacaca cagcacaggc atcacccagt 420 gtgacatcta taacaccctt ctgggcctgc ccgctgacat ccaggctgcc cangccatga 480 tggtgacatc cagtgcaatc tcctccctgg cctgcattat ctctgtggtg ggcatganat 540 gcacagtctt ctgccaggna atcccgaacc aaanacanaa tggcggtanc aggtggaatc 600 tttttcatcc ttgga 615 <210> 398 <211> 675 <212> DNA <213> Homo sapiens <400> 398 gcggtcacgt gactgctgcg ggccagccaa gatggcggcc tcatgcttgg tcctgctggc 60 gctgtgtctg ctgctgccgc tgctgctgct gggaggatgg aagcgctggc gccgggggcg 120 ggcggcccgg catgtantan cggtggtgct gggcgacgtg ggccgcancc cccgtatgca 180 gtaccacgcg ctgtcgttgg ccatgcacgg cttctcggtg accctcctgg ggttctgcaa 240 ctccaaaccc catgatgagc tcttgcagaa caacagaatt cagattgtgg ggttgacaga 300 acttcanant cttgcagttg ggccccgggt tttccagtac ggantcaaag ttgtacttca 360 ggctatgtac ttgctgtgga agctgatgtg ganggagcca ggtgcctata tctttctcca 420 gaacccccca ngtctgccga acattgctgt ctgctggttc ctgggctgcc tttgtggaaa 480 caaactcgtc attgactggc acaactatgg ctactccatc atgggtctgg tgcatggccc 540 caaccatccc ctcnttctgc tgggcaagtg gttaccaaaa aattctttgg ggcgcctgtc 600 ccaccctgaa ctgttttttt ancaatgcta tnccaaaaaa actgggcgga taactggcac 660 atcagggntn tnaac 675 <210> 399 <211> 732 <212> DNA <213> Homo sapiens <400> 399 aggtccgcgg ctgctgctgc gtccgacccc cggccggcgc gggtatggag cttgggggtc 60 actgggacat gaactcggcc ccgaggctgg tctcggagac cgcagagcgg aaacaggagc 120 agaagacagg aaccgaggcg gaggctgccg actccggtgc cgtcggagcc cgccgcttcc 180 tgctctgtct ctacttggtg ggcttcttgg atttgtttgg tgtcagcatg gttgtgcctt 240 tattgancct tcatgtcaag tcccttggag caagtccaac agttgctgga atagtaggct 300 cctcctatng cattttgcaa ctcttttcta gcacattggt gggctgctgg aacgatgtan 360 tgggaagacg gtcttccttg ctggcatgca ttctactcag tgctctgggc tatctccttc 420 tcggancaac caccaatgtg tttctgtttg tcctgggtan aatcccggca ggtattttta 480 aaacacactc tctccatctc aagggctcta ctttctgatg tggttccaga aaaaagaacg 540 ggccgcttgt aatcgggaca cttcaacaca gcctccggtg ttgggcttca atcnttgggg 600 cccccgtggt cngtggctat cccactgaaa ttagaaggat gggtttttat ctcacaancc 660 cntccatcct ggctttttgg gtccttcnat tcctcaatng cttgggttct ccgttttggg 720 tttcctttnc ca 732 <210> 400 <211> 598 <212> DNA <213> Homo sapiens <400> 400 ggctcgcanc catggcggcc gccgcgctcc cagcatggct gtctctgcag tcgagggcaa 60 ggactctgcg tgcattctcc actgccgtct actcggccac tccggtcccg acacctagcc 120 tgccggaaag aacacccgga aatgaaaggc caccaagaan aaaggcacta cctcctagga 180 caganaaaat ggctgttgac caggactggc ctagtgttta cccagttgca gcaccattta 240 aaccctctgc agtacctctt cctgttcgaa tgggttatcc agtaaaaaag ggcgtgccca 300 tggcaaagga nggaaatcta aaacttttaa agattcccaa ttttctgcat ttgactcctg 360 tagcaattaa aaagcactgt gaagccctta aagatttttg cactgagtgg ccaaccgcac 420 tggacagtga cnaaaaatgt nagaagcatt ttccaattga aattgacagc actgattatg 480 tttcatcagg accatctgtt cggaaccccn naacacgaat tagtantctt aanaatgccc 540 tttaaggaag cagaaattac gattatgcag tgtntctact aacagtgtta taccatga 598 <210> 401 <211> 758 <212> DNA <213> Homo sapiens <400> 401 tccgatccca ttccatccgt tcctcgtctc ctcccggtct gacccgttgc ccggccgtgg 60 ttcgccacac caggcatcca aagctgaggt cgctcctacg gcctgggctc gccttcgctt 120 tananatgtt tggcctcttc cctcccaaac agcccatctt caaaacctgg actcttggac 180 tggcacctgg ccacctttcc ctctaccaag actccacttc cgtcttaccc acttcttcct 240 canattcttg gtaccccctg ggttgganac tgctcatttt cctcccaaat taatcccaga 300 ccccctaaaa tattgacaac cttgacaacc ccccaaccga ggaaccanac tttgttttgg 360 actaacttcc atanccctgt catggangca gtgtncctgg taatgaatgg gttgggcctg 420 gtgctggacg tnctgacctt ggtgttggac ctcaacttcc tgctggtgtc ctccctcctg 480 gcttccctgg cctggctcct ggccttcgtc tacaacctgc cgcacacggt actgantaat 540 cttctgcact tggggcgcgg aatcttgctt tcattgctgg gcttgatcga aacgtggtcc 600 ggttcacatn tnggggnttg caagccttgt gttctctgct gtataactgc tgctctgggc 660 taaaaaaact aaaactcctg gggggactgg cctctcattg ggggactgcn gaacaaggga 720 aaaatantgn ncccgggggg ttctccatgt ngttctcc 758 <210> 402 <211> 764 <212> DNA <213> Homo sapiens <400> 402 ttgtatgata aggcaggtaa agtgaggaaa catgcaactg aacaggaaaa aactgaagag 60 ggattaggcc ctaatataaa aagcattgtc accatgttga tgctgatgct attgatgatg 120 tttgctgtcc actgtacctg ggtcacaagc aatgcctact ctagtccaag tgtagtcctg 180 gcctcataca atcatgatgg caccaggaat atcttagatg attttagaga agcttacttt 240 tggctaaggc aaaatacaga tgaacatgca cgagtaatgt cttggtggga ttatggctat 300 cagatagctg gaatggctaa tagaactacg ttggtggata ataacacctg gaataacagc 360 cacatagcac tggtgggaaa agctatgtct tctaatgaaa cagcagccta taaaatcatg 420 aggactctag atgtanatta tgttttggtt atttttggag gggttattgg ctattctggt 480 gatgatatca acaaatttct ctggatggtt aggatagctg aaggagaaca tcccaaagac 540 attcgggaaa gtgactattt taccccacag gggagaattc cgtgttagac aaagcaggat 600 cccctacttt gttgaattgc cttatgtata aaatgtcata ctacaaattt ggaaaaaatg 660 ccactggatt ttcntacccc cccaggtttt gaccgaacac nttattgctg aaattggaaa 720 ataaggacnt taaattccaa cntttgggaa aaaanccttt acat 764 <210> 403 <211> 468 <212> DNA <213> Homo sapiens <400> 403 gtcccgcagt ggctggagcc ctgggcgctg caaagcgtgt cccgccgggt ccccgagcgt 60 cccgcgccct cgccccgcca tgctcctgct gctggggctg tgcctggggc tgtccctgtg 120 tgtggggtcg caggaagagg cgcaganctg gggccactct tcggancagg atggactcag 180 ggtcccgagg caagtcagac tgttgcagan gctgaaaacc aaacctttga tgacagaatt 240 ctcagtgaan tctaccatca tttcccgtta tgccttcact acggttccct gcagaatgct 300 gaacaganct tctgaagacc aggacattga gttccagatg cagattccag ctgcagcttt 360 catcaccaac ttcactatgc ttattggana caaggtgtat cagggcgaaa ttacngagag 420 agaaaagaan antggtgata gggtnaaaga aaaaaggaat aaaaccac 468 <210> 404 <211> 560 <212> DNA <213> Homo sapiens <400> 404 gtgtggagaa agcggcagct gtcccagcgg naagcgacga agggacggga cccgggagcc 60 tggacgagtc cgagcgcgtc acctcctcac gctgcggctg tcgcccgtgt cccgccggcc 120 cgttccgtgt cgccccgcag tgctgcggcc gccgcggcac catggctgtg tttgtcgtgc 180 tcctggcgtt ggtggcgggt gttttgggga acgagtttag tatattaaaa tcaccagggt 240 ctgttgtttt ccgaaatgga aattggccta taccaggaga gcggatccca gacgtggctg 300 cattgtccat gggcttctct gtgaaagaag acctttcttg gccaggactc gcagtgggta 360 acctgtttca tcgtcctcgg gctaccgtca tggtgatggt gaagggagtg aacaaactgg 420 ctctaccccc aggcagtgtc atttcgtacc ctttggaaaa tgcanttcct tttantcttg 480 acagtgttgc aaattccatt cactccttat tttctganga aactcctgtt gttttgcant 540 tggctcccan tgaagaaaga 560 <210> 405 <211> 770 <212> DNA <213> Homo sapiens <400> 405 agtgcctttg gcgcactgag gtgcacaggg tcccttagcc gggcgcaggg cgcgcagccc 60 angctgagat ccgcggcttc cgtaaaagtg agcatggctg ggcagcgagt gcttcttcta 120 gtgggcttcc ttctccctgg ggtcctgctc tcagaggctg ccaaaatcct gacaatatct 180 acagtaggtg gaagccatta tctactgatg gaccgggttt ctcanattct tcaagatcac 240 ggtcataatg tcaccatgct taaccacaaa agangtcctt ttatgccaga ttttaaaaag 300 gaanaaaaat catatcaagt tatcagttgg cttgcacctg aanatcatca aagagaattt 360 aaaaagantt ttgatttctt tctggaagaa actttaggtg gcagaagaaa atttgaaaac 420 ttattaaatg ttctagaata cttggcgttg cagtgcagtc attttttaaa tagaaaagga 480 tatcntggat tccttaaaga atgagaactt cgacatggtt gatagttgaa acttttgact 540 actgtccttt cctgattgct gaaaaacttg gggaanccat ttgtggccat tctttccact 600 tcattcngct ctttgggaat ttgggctacc aatccccttg tcttatgttc ccatattccg 660 ttccttgctg actgatccat tngacttctg gggggcccaa attaaaaaat ttccgaatgt 720 tcctttaant ttcctgccag gaaggcaacc accccnttgc cantcttang 770 <210> 406 <211> 669 <212> DNA <213> Homo sapiens <400> 406 cgaccgagcc gagaggaccg agtggggccg aggccagtag ccccggggcc ctgagcagan 60 gccgtagctt gcgccgcacc cgcggccagg cggagccaaa gatgccggcc tctgctgcgc 120 ggccccgccc gggtcccggg cagcctacag cctcgccctt cccgctactg ctgctggcgg 180 tgctgagcgg cccggtatcc ggccgcgtcc cccgctcggt gcccagaacc tcgcttccaa 240 tctctgaggc tgactcctgt ctcacccggt tcgcagtccc tcacacatac aattactctg 300 ttctccttgt ggatcctgcc tcccacacac tttatgttgg cgcccgggac accatcttcg 360 ctttatccct gcccttctca ggggagagac cccgcangat tgactggatg gttcctgang 420 ctcacanaca gaactgtagg aagaaaggca agaaaganga cgaatgtcac aattttgtcc 480 agattctcgc cattgccaat gcctctcacc tcctcacttg tggcaccttc gcttttgatc 540 cgaaattgcg gggttattga tgtgtccagg ttccccnggt tgaaaaactt gaaaatggnc 600 ggggggaaat gtccttttga accactcncg gtcancaact tgttattggc tgggggggtt 660 ctntattct 669 <210> 407 <211> 775 <212> DNA <213> Homo sapiens <400> 407 aatattgcca ggtccactgg atctcaaata gcccagcaac cattttccaa ggggacttct 60 ggcaaccagg taaccataac agttgtgcca aatacgagtt ttgcacctgc aactgtgagt 120 cagggaaatg caactcagct cattgctcca gcaggaatta ccatgagcgg aacgcagaca 180 ggagttggac ttccagtaca aacgcttcca gccactcaag catctcctgc tggacaatca 240 tcatgtacta ctgctactcc cccattcaaa ggtgataaaa taatttgcca aaaggaggag 300 gaagcaaagg aagcaacagg tttacatgtt catgaacgta aaattgaagt catggagaac 360 ccgtcctgcc gacgangagc cacaaacacc agcaatgggg atacaaagga aaatgaaatg 420 catgtgggaa gtcttttaaa tgggagaaag tacagtgact caagtctacc tccttcaaac 480 tcagggaaaa ttcaaagtga gactaatccg tgctcactaa tcagtaatgg gccatcattg 540 gaattaggtg agaatggagc atctgggaaa cagaactcag aacaaataga catgccagat 600 atcaaaagtg atttgagaaa aaccgctagt taatggaatc tgttgatttt ganaaaagga 660 natggttctc atttaagcaa aaacattccc caattcataa aactcccntc catgttggaa 720 atggttgaaa atatctccca tgggaaccnc caaggggact ttanaatatc nctcn 775 <210> 408 <211> 723 <212> DNA <213> Homo sapiens <400> 408 gaaggaanat ggcacctgcc ggctgctgct gctgctgctg cttctggggc ggcgctgtgg 60 ccgccgcggg cgccgcccgg cgtgtcctgc tgctgctgct gctgggggtc ctgtccgctg 120 ggctgcggcc aggcgccctg gccaccganc actactcgcc gctctccctg ctcaagcagg 180 agctgcagca ccggcagcag caagaggccc cggcgggcgg cggcggctgc agcccgcagt 240 ccggggactg gggggaccag tactctgccg agtgcggcga ntcatccttt ttgaacttcc 300 atgactcaga ctgcgaaccc aagggatcat caccctgtga ctccttgctt tccctcaaca 360 ctgagaanat tctgagccag gccaagtcta ttgcagaaca gaagagattc ccgtttgcca 420 ctgatnatga cagcacaaat gaananttag ctattgctta tgtcttgatt ggcagtggtc 480 tgtatgatga aacaatacgg catttttcaa caatgcttca ggaagancct gatctggtta 540 gtgcaattta tggccgaagg atanccnatg gaaagaaagg actacatgac attnagaatg 600 ctgaacttgc tctgttcnaa ctgaacccaa ttnattacct tggaaacaga tcgtcccaga 660 agttatttta aacnncgaac aaaaattctt gtccccccct ggggaacaaa ttaattgaaa 720 ncn 723 <210> 409 <211> 735 <212> DNA <213> Homo sapiens <400> 409 anaggcgcgg cgtgactgag ctacggttct ggctgcgtcc canaggcatc cggggcagta 60 aaaccgctgc gatcgcggag gcggcggcca agccgaaagg caggccgggc aggggtgtcg 120 gacgcagggc gctgggccgg gtttcggctt cggccacagg agtcatagag gctgggtggt 180 ctggcaagga cttgtgcatt tgagaactga caggtgcagc ggagacttct aagagggaaa 240 accaagcttt ttttctcaag gtgcaatgaa agccttccac actttctgtg ttgtccttct 300 ggtgtttggg agtgtctctg aagccaagtt tgatgatttt gaggatgang aggacatant 360 anagtatgat gataatgact tcgctgaatt tgaggatgtc atggaagact ctgttactga 420 atctcctcaa cgggtcataa tcactgaaga tgatgaagat ganaccactg tgganttgga 480 agggcangat gaaaaccaag aaggagattt tgaagatgca gatacccagg agggagatac 540 tganagtgaa ccctatgatg atgaagaatt tgaaggttat gaagacaaac cagatacttc 600 ttctancaaa aataaagacc aataaccaat tgttgatgtt cctgcccccc tcccanaaca 660 gctggggaaa aattattatc tanaaatttt gatgggtgac tgggtctgct tgctttatat 720 cnnngaatta cctcc 735 <210> 410 <211> 673 <212> DNA <213> Homo sapiens <400> 410 aggggacngt tgctggccca ggtgagcggg cgcgctggtc caggtgagcg ggcgcgtccc 60 cccgacggcg ctgcctgccc gaggcggttc acgtaaagac agcgagatcc tgagggccag 120 ccgggaagga agcgtggata tggagctggc tgctgccaag tccggggccc gcgccgctgc 180 ctagcgcgtc ctggggactc tgtggggacg cgccccgcgc cgcggctcgg ggacccgtan 240 agcccggcgc tgcgcgcatg gccctgctct cgcgccccgc gctcaccctc ctgctcctcc 300 tcatggccgc tgttgtcagg tgccaggagc aggcccagac caccgactgg agagccaccc 360 tgaagaccat ccggaacggc gttcataaga tagacacgta cctgaacgcc gccttggacc 420 tcctaggagg cgaggacngt ctctgccagt ataaatgcag tgacngatct aancctttcc 480 cacgttatgg ttataaaccc tccccaccga atggatgtgg ctctccactg tttggtgttc 540 atcttaacat tggtntccct tccctgacaa agtgttgcaa ccaacacgac aggtgctatg 600 anacctgtgg caaaaccaga atgactgtga tgaaaaatcc ngtattgnct ctcccanatc 660 tgccgaaatn ttc 673 <210> 411 <211> 633 <212> DNA <213> Homo sapiens <400> 411 ctcctgccan cgcgctctct gtttctctgc agccccgaag ctcgcgaatg tagcaggcgc 60 cccaagctcg gtcctcaana agccatggcg gaatccaggg gccgtctgta cctttggatg 120 tgcttggctg ctgcgctggc atctttcctg atgggattta tggtgggctg gtttattaag 180 cctctcaaag aaacgaccac ttctgtgcgc tatcatcnaa gtatacggtg gaaactggta 240 tccgaaatga aagctgaaaa catcaaatca tttcttcgtt cttttacaaa gcttcctcat 300 ctggcaggaa cagaacaaaa tttcttgctt gccaagaaaa tccaaaccca gtggaagaaa 360 tttggactac attcagccaa gttggttcat tatgatgtcc tcttatctta ccccaatgan 420 acaaatgcca actatatatc gattgtggat gaacatgaaa ctgagatttt caaaacatcn 480 taccttgaac caccaccaga tggctatgan aatgttncaa atattgtgcc accatataat 540 gctttctcag cccaaggcat gccagaagga natcttgtat atgtgaacta tgctcgcnct 600 gaanactttt tcaaactaga aagaaanatn ggc 633 <210> 412 <211> 467 <212> DNA <213> Homo sapiens <400> 412 aagccgggcc ccccagcggt cggcgggacg gctcccggct gcagtctgcc cgcccgcccc 60 gcgcgggggc cgagtcgcga agcgcgcctg cgacccggcg tccgggcgcg ctggananga 120 cgcgaggagc catgaggcgc cagcctgcga aggtggcggc gctgctgctc gggctgctct 180 tggantgcac anaagccaaa aagcattgct ggtatttcga aagactctat ccaacctatt 240 atatatgccg ctcctacaan gactgctgtg gctccaggtg ctgtgtgcgg gccctctcca 300 tacaaangct gtggtacttc tggttccttc tgatgatggg cgtgcttttc tgctgcggag 360 ccggcttctt catccggang cgcatgtncc ccccgccgct gatctangac cagccttcaa 420 tgtgtcctac accaggcanc ccccaaatcc cggcccanga acccagc 467 <210> 413 <211> 477 <212> DNA <213> Homo sapiens <400> 413 agttccggac gcgggcccag ccgcgcctgc gcctccgctc gcctgtggct gcgtcgcgcg 60 ctcttcctcg gagctatcca ggcggctggt gtgcagcaag ctccgcgccg accccggacg 120 cctgacgcct gacgcctgta cccggccccg catgagccgc tacctgctgc cgctgtcggc 180 gctgggcacg gtagcaggcg ccgccgtgct gctcaaggac tatgtcaccg gtggggcttg 240 ccccagcaag gccaccatcc ctgggaagac ggtcatcgtg acgggcgcca acacaggcat 300 cgggaagcag accgccttgg aactggccag gaaangangc aacatcatcc tggcctgccg 360 agacatggaa aaatgtgagg cggcagcaaa ngacatccgc ggggagacct caatcaccat 420 gtctacgccc ggcacctgna cttggcttcc ctcanntcta tccnaatgtt tgcagca 477 <210> 414 <211> 745 <212> DNA <213> Homo sapiens <400> 414 gcgcgctccc tgtgaggtgg gcaagcggcg aaatggcgcc ctccgggagt cttgcagttc 60 ccctggcagt cctggtgctg ttgctttggg gtgctccctg gacgcacggg cggcggagca 120 acgttcgcgt catcacggac gagaactgga gagaactgct ggaaggagac tggatgatag 180 aattttatgc cccgtggtgc cctgcttgtc aaaatcttca accggaatgg gaaagttttg 240 ctgaatgggg agaagatctt gaggttaata ttgcgaaagt agatgtcaca gagcagccag 300 gactgagtgg acggtttatc ataactgctc ttcctactat ttatcattgt aaagatggtg 360 aatttaggcg ctatcagggt ccaaggacta agaaggactt cataaacttt ataagtgata 420 aagagtggaa gagtattgag cccgtttcat catggtttgg tccaggttct gttctgatga 480 gtagtatgtc agcactcttt cagctatcta tgtggatcag gacgtgccat aactacttta 540 ttgaagacct tggnttgcca ncgtggggat catatactgt ttttgcttta acaactctgt 600 tttccggact gttattangg actctgtatg atatttgtgg caaatttgcc tttggccttc 660 aaaaagggcg caaaccacag ccaataccca tacccttcaa aaanattatt ancaaaatct 720 gcacaacctt tnnaaaaaaa gtggn 745 <210> 415 <211> 637 <212> DNA <213> Homo sapiens <400> 415 agacttgggc tggagccgcc ctgggtgtca gcggctcggc tcccgcgcac gctccggccg 60 tcgcgcagcc tcggcacctg caggtccgtg cgtcccgcgg ctggcgcccc tgactccgtc 120 ccggccaggg agggccatga tttccctccc ggggcccctg gtgaccaact tgctgcggtt 180 tttgttcctg gggctgagtg ccctcgcgcc cccctcgcgg gcccagctgc aactgcactt 240 gcccgccaac cggttgcagg cggtggaggg aggggaagtg gtgcttccag cgtggtacac 300 cttgcacggg gaggtgtctt catcccagcc atgggaggtg ccctttgtga tgtggttctt 360 caaacagaaa gaaaaggagg atcaggtgtt gtcctacatc aatggggtca caacaagcaa 420 acctggagta tccttggtct actccatgcc ctcccggaac ctgtccctgc ggctggaggg 480 tctccaagga gaaagactct ggccctacag ctgctccgtt gaatgtgcaa gacaaacaaa 540 ggcaaatcta agggccacaa gcatcaaaaa ccttanaact caatgtactg gttcctccan 600 ctcntccatc cttgncgtct ccaagngtgt gccccat 637 <210> 416 <211> 613 <212> DNA <213> Homo sapiens <400> 416 aaactcccat ctccctcacc aagccggaaa gtacgagtcg gctcagcctg gagggaccca 60 accagagcct ggcctgggag ccaggatggc catccacaaa gccttggtga tgtgcctggg 120 actgcctctc ttcctgttcc caggggcctg ggcccagggc catgtcccac ccggctgcag 180 ccaaggcctc aaccccctgt actacaacct gtgtgaccgc tctggggcgt ggggcatcgt 240 cctggaggcc gtggctgggg cgggcattgt caccacgttt gtgctcacca tcatcctggt 300 ggccagcctc ccctttgtgc aggacaccaa gaaacggagc ctgctgggga cccaggtatt 360 cttccttctg gggaccctgg gcctcttctg cctcgtgttt gcctgtgtgg tgaagcccga 420 cttctccacc tgtgcctctc ggcgcttcct ctttggggtt ctgttcgcca tctgcttctc 480 ttgtctggcg gctcacgtct ttgccctcaa cttcctggcc cggaagaanc acgggccccg 540 gggctgggtg atcttcactg tggntctgct gctgaccctg gtataggtca tcatcantac 600 angagtggnt gat 613 <210> 417 <211> 543 <212> DNA <213> Homo sapiens <400> 417 cttgactttg agcgtccggc ggtcgcagag ccaggaggcg gaggcgcgcg ggccagcctg 60 ggccccagcc cacaccttca ccagggccca ggagccacca tgtggcgatg tccactgggg 120 ctactgctgt tgctgccgct ggctggccac ttggctctgg gtgcccagca gggtcgtggg 180 cgccgggagc tancaccggg tctgcacctg cggggcatcc gggacgcggg aggccggtac 240 tgccaggagc aggacctgtg ctgccgcggc cgtgccgacg actgtgccct gccctacctg 300 ggcgccatct gttactgtga cctcttctgc aaccgcacgg tctccgactg ctgccctgac 360 ttctgggact tctgcctcgg cgtgccancc ccttttcccc cgatccaagg atgtatgcat 420 ggaaggtccg tatctatcca ntcttgggaa cgtnctggga caactgtaac cgttgcaact 480 gccaggagaa caggcagtgg caagtgtgnc caagaaccat gcctggnggg atccagncat 540 gnt 543 <210> 418 <211> 474 <212> DNA <213> Homo sapiens <400> 418 gctagagctc tcgactctcc gctgcgcggc agctggcggg gggagcagcc aggtgagccc 60 aagatgctgc tgcgctcgaa gcctgcgctg ccgccgccgc tgatgctgct gctcctgggg 120 ccgctgggtc ccctctcccc tggcgccctg ccccgacctg cgcaagcaca ggacgtcgtg 180 gacctggact tcttcaccca ggagccgctg cacctggtga gcccctcgtt cctgtccgtc 240 accattgacg ccaacctggc cacggacccg cggttcctca tcctcctggg ttctccaaag 300 cttcgtacct tggccagagg cttgtctcct gcgtacctga ngtttggtgg caccaagaca 360 gacttcctaa ttttcgatnc caagaaggaa tcaacctttg aaganagaaa ttactggnaa 420 tctcaagtca accangatat ttgaaatatg gntcatcctc ctgaagttgg agga 474 <210> 419 <211> 593 <212> DNA <213> Homo sapiens <400> 419 aagattttcg gccccatggc cagcgtcggg aacatggatg agaaatccaa caagctgctg 60 ctagctttgg tgatgctctt cctatttgcc gtgatcgtcc tccaatacgt gtgccccggc 120 acagaatgcc agctcctccg cctgcaggcg ttcagctccc cggtgccgga cccgtaccgc 180 tcggaggatg agagctccgc caggttcgtg ccccgctaca atttcacccg cggcgacctc 240 ctgcgcaagg tagacttcga catcaagggc gatgacctga tcgtgttcct gcacatccan 300 aagaccgggg gcaccacttt cggccgccac ttggtgcgtn acatccagct ggagcagccg 360 tgcgantgcc gcgtgggtca naaaaaatgc acttgccacc ggccgggtaa gcgggaaact 420 ggctcttctc caagttctcc acgggctgga gctgcgggtt gcacgccgac tggaccgaac 480 tcaccagctg tgtgccctcc gtgggtggac ggcaagcgcg acgccnggct ganaacgtcc 540 aggaaacttc cactacatca ccatcctccg aaanccantg tccnggtact tga 593 <210> 420 <211> 860 <212> DNA <213> Homo sapiens <400> 420 ctccatctca gagcctctcc tcaatctcaa gcctccactc ccctcatgcc caggcactcc 60 acggctgtga agatggcggc ggctgcgtgg cttcaggtgt tgcctgtcat tcttctgctt 120 ctgggagctc acccgtcacc actgtcgttt ttcagtgcgg gaccggcaac cgtagctgct 180 gccgaccggt ccaaatggca cattccgata ccgtcgggga aaaattattt tagttttgga 240 aagatcctct tcagaaatac cactatcttc ctgaagtttg atgganaacc ttgtgacctg 300 tctttgaata taacctggta tctgaaaagc gctgattgtt acaatgaaat ctataacttc 360 aaggcagaag aagtagantt gtatttggaa aaacttaagg aaaaaagagc ttgtctggga 420 aatatcaaac atcatcaaaa ttgttccaga actgcagtga actctttaaa acacagacct 480 tttctggaga ttttatgcat cgactgcctc ttttaggana aaaacaggan gctaaggana 540 atggaacaaa ccttaccttt attggagaca aaaccgcaat gcatgaacca ttgcaaactt 600 ggcaagatgc accatacatt tttattgtac atattggcat ttcatcctca aaggaatcat 660 cnaaagaaaa ttcnctgaat taatcttttt accatgactg tttnaaatta aaggtcccta 720 tgaaatacct cncacttgaa aaactatccc ttgatnaatt ttttccatgg tgaangtntt 780 attggtatat gttcccgttt gggtgttcct gttggcttgg gcattggtcc tgccctgcta 840 cttgggaaaa aantntncct 860 <210> 421 <211> 556 <212> DNA <213> Homo sapiens <400> 421 ctcgacgggc aagcggcgat aagaggtggc gtcctccgcg gcattgcgag caccgccagt 60 ctgcgccgcc aggcgtaggc ggggtggccc ttgcgtctcc cgcttccttg aaaaacccgg 120 cgggcgagcg aggctgcggg ccggccgctg cccttcccca cactccccgc cgagaagcct 180 cgctcggcgc ccaacatggc gggtgggcgc tgcggcccgc agctaacggc gctcctggcc 240 gcctggatcg cggctgtggc ggcgacggca ggccccgagg aggccgcgct gccgccggaa 300 cagaaccggg tccagcccat gaccgcctcc aactggacgc tggtgatgga gggcgagtgg 360 atgctgaaat tttacgcccc atggtgtcca tcctgccagc agactgattc agaatgggag 420 gcttttgcaa agaatggtga aatacttcag atcagtgtgg ggaaggtaga tgtcattcaa 480 gaaccaggtt tgaatggccg cttctttgtc nccactctcc cancattttt tcatgcaaag 540 gatnggatat tccgcc 556 <210> 422 <211> 575 <212> DNA <213> Homo sapiens <400> 422 accgtaacca gcgccgcgga caccggcacc ggcgccacgg actccgcang accccgcgcc 60 cgccgccgcc gctatgctgg ggctgctggt ggcgttgctg gccctggggc tcgctgtctt 120 tgcgctgctg ggcgtctggt acctggtgcg ccttccgtgc gccgtgctgc gcgcgcgcct 180 gctgcagccg cgcgtccgtg acctgctagc tgagcagcgc ttcccgggcc gcgtgctgcc 240 ctcggacttg gacctgctgt tgcacatgaa caacgcgcgc tacctgcgcg aggccgactt 300 tgcgcgcgtc gcgcacctga cccgctgcgg ggtgctcggg gcgctgaggg agttgcgggc 360 gcacacggtg ctggcggcct cgtgcgcgcg ccaccgccgc tcgctgcgcc tgctggaacc 420 cttcgaggtg cgcaccgcct gctgggctgg gacgacgcgc gttctacctg gaagcgcgct 480 ttgtcacctg cgggacggtt tcgtgtgcgc gctgctgcgc ttccggcanc acctgctggg 540 cacctcaccc naacgcgtcn tgcacacctg ttcca 575 <210> 423 <211> 517 <212> DNA <213> Homo sapiens <400> 423 agctggcgct ggaggcttcg gcgtcacgtg ctggtctgga tttttctcga tgcactgggg 60 aaagcggtgg actcttatcg tgggagggct cttgatctgt gatttataga taggcacagg 120 gaacccaacg gcagacaggt cctagtgccc atcagatacc cgcggccggg actcgganct 180 gtggggtgtg gggaggcgga ggcaccaact aagagcggcc tancatcgca aanccgccct 240 cggggcgctc atggcgggac gcctcctggg aaaggctttg gccgcggtgt ctctctctct 300 ggccttggcc tctgtgacta tcaggtcctc gcgctgccgc ggcatccang cgttcagaaa 360 ctcgttttca tcttcttggt ttcatcttaa taccaacgtc atgtctggtt ctaatggttc 420 caaanaaaat tctcacaata aggctcggac ntctccttac ccangttcaa aagttgaacg 480 aagccangtt cctaatgana aagtgggctg gcttgtt 517 <210> 424 <211> 640 <212> DNA <213> Homo sapiens <400> 424 gaactgtgtg gaccgtctgc tgggactccg gccctgcgtc cgctcagccc cgtggccccg 60 cgcacctact gccatggaga cgcggcctcg tctcggggcc acctgtttgc tgggcttcag 120 tttcctgctc ctcgtcatct cttctgatgg acataatggg cttggaaagg gttttggaga 180 tcatattcat tggaggacac tggaagatgg gaagaaagaa gcagctgcca gtggactgcc 240 cctgatggtg attattcata aatcctggtg tggagcttgc aaagctctaa agcccaaatt 300 tgcagaatct acggaaattt cagaactctc ccataatttt gttatggtaa atcttgagga 360 tgaagaggaa cccaaagatn aanatttcag ccctgacggg ggttatattc cacgaatcct 420 ttttctggat cccagtggca aggtgcatcc tgaaatcatc aatgagaatg gaaaccccag 480 ctacaagtnt ttttatgtca gtgccgagca agttgttcag gggatgaagg aagctcagga 540 aaggctgacg ggtgatgcct tcagaaagaa acatcttgaa gatgaattgt aacatgaatg 600 tgccccttct ttcatcaaaa ttagtgttct gggnaaaaaa 640 <210> 425 <211> 388 <212> DNA <213> Homo sapiens <400> 425 gcacagggga gccggctaaa acagactact cccccgtgca gtcgttccct ctaccctaat 60 aaggctttgg cgcctctccc agaactcggt cctggggaat gctctttgcc tggtccagcc 120 ccgacaaacg tggtctgaga acagcggagc gcggaaaccg cggagcatga ctcctccgaa 180 gctgcgagcg tcgctgtcgc cgtcgctgct gctgctgctg agtggttgcc tcctcgcggc 240 tgctcggagg gagaaagggg cggctagcaa cgtggcggag ccggtccccg ggcccactgg 300 cggctcctcg ggtcgcttcc tcagccccga gcagcacgcg tgcagctggc agctcctgct 360 gcccgccccg gangccgcan cgggcanc 388 <210> 426 <211> 650 <212> DNA <213> Homo sapiens <400> 426 agtctgtcgg agtctgtcct cgggagcagg cggagtaaag ggacttgagc gagccagttg 60 ccggattatt ctatttcccc tccctctctc ccgccccgta tctcttttca cccttctccc 120 accctcgctc gcgtagccat ggcgggaacc gtcggcggcc actcagtccc attccatctc 180 ctcgtcgtcc ttcggagccg agccgtccgc gcccggcggc ggcgggagcc cangagcctg 240 ccccgccctg gggacgaaga gctgcagctc ctcctgtgcg gtgcacgatc tgattttctg 300 gagagatgtg aanaagactg ggtttgtctt tggcaccacg ctnatcatgc tgctttccct 360 ggcagctttc agtgtcatca gtgtggtttc ttacctcatc ctggctcttc tctctgtcac 420 catcagcttc aggatctaca agtccgtcat ccaagctgtn cagaagtcag aagaagccat 480 ccattcaaag cctacctgga cgtanacatt actctgtcct cagaagcttt ccataattac 540 atgaatgctg ccatggtgca catcaacagg gccctgaaac tcnttattcg tctctttctg 600 gtnnaaaatc tggttgactc cttgaaagct ggctgtcttc ntgtngctga 650 <210> 427 <211> 518 <212> DNA <213> Homo sapiens <400> 427 gtgcgtttgt ggccgtccgg cctccctgac atgcagccct ctggaccccg aggttggacc 60 ctactgtgac acacctacca tgcggacact cttcaacctc ctctggcttg ccctggcctg 120 cagccctgtt cacactaccc tgtcaaagtc agatgccaaa aaagccgcct caaagacgct 180 gctggagaaa gtgaagtttt gctcttgttg cccaggctgg agcgcaatgg cgcgatcttg 240 gctcaccgca acctctgcca cccagagtca gttttcagat aagccggtgc aagaccgggg 300 tttggtggtg acggacctca aagctgagag tgtggttctt gagcatcgca gctactgctc 360 ggcaaaggcc cgggacagac actttgctgg ggatgtactg ggctatgtca ctccatggaa 420 cagccatggc tacgatgtca ccnaggtctt tgggagcaaa ttcacacaga tctcacccgt 480 ctggctgcag ctgaagagac tngccgtgan atgtttga 518 <210> 428 <211> 487 <212> DNA <213> Homo sapiens <400> 428 gtgctgcccg ctcaccgccc gccatggccc gcgcaccccc gctgctcgcc gcgttgaccg 60 cgctcctcgc cgccgccgct gctggcggag atgccccgcc gggcaaaatc gcggtggttg 120 gggctgggat tgggggctct gctgtggccc attttctcca gcagcacttc ggacctcggg 180 tgcagatcga cgtgtacgag aagggaaccg tgggtggccg cttggccacc atctcagtca 240 acaagcagca ctatgagagc ggggctgcct ccttccactc cctgagcctg cacatgcagg 300 acttcgtcaa gctgctgggg ctgangcacc ggcgcgaggt ggtgggcang agcgccatct 360 tcggcgggga gcacttcatg ctggaggaga ctgactggta cctgctgaac ctcttccgcc 420 tctggtggca ctatggcatc agcttcctga ggctgcanat gtgggtggag gangtcatgg 480 anaattc 487 <210> 429 <211> 612 <212> DNA <213> Homo sapiens <400> 429 agccagggaa gcctccgcgg tggtgcaagt ggaacccaag ccttgaggtt tcagtgagta 60 gggggccgac gtgagcttta gcgtccccct ttagcctccc tcttcgattc cttgaagacc 120 ctggtgcagc ttagcaagag ggcccaggat ttttggatcc ccagccctgt gacaagggtt 180 cctgtccagt ttccccctcc caggatttcg actcagttca gcgaagtcac cgccccgtct 240 gagaaatgag gacaccaagg cttagagcac agccccgagg cgccgtctac caggccccgt 300 cccctccccc ggctcctgtc tgtcagcact gaaaccccgt ccctgctcca ggcctccttc 360 tctggggtcc aaggtcccat acaggcctct gcctcggccg caggcccttc agtcaccgtc 420 gcctcgtctc cctgactgtc cgcaggcctg ggcagcatgg ccgtattccg gtcgggtctc 480 ctggtgctga cgacgccgct ggcctcccta gcccctcgcc tggcctccat cctgacctcg 540 gcggcccggc tggtgaatca cacactctat gttcacctgc anccggggca tnaacctgga 600 aggcccggnt ca 612 <210> 430 <211> 441 <212> DNA <213> Homo sapiens <400> 430 gctaatatgc tccctctccc acaaggcagc gcgccggctc ggacgcggcc ggctaccgag 60 accctttgtg agagctgtga gctgcgcctg acggtagcac catgatcatc tcaggtgggg 120 cgcccggggc gtccgncanc tctgcgccgc ccgcgcagga agagggcatg acgtggtggt 180 accgctggct gtgtcacctg tctggggtgc tgggggcagt ctcttgcgcg atctctggcc 240 tcttcaactg catcaccatc caccctctga acatcgcggn cggcgtgtgg atgatgatgg 300 cggtcgttcc catcgtcatc agtctgaccc tcaccacgct tctgggcaac gccttcgcct 360 gtgctacggg ggtgctgtac ggactctctg ctctgggcaa aaagggcgat gccatctcct 420 cttcnatgat ccannagcag a 441 <210> 431 <211> 716 <212> DNA <213> Homo sapiens <400> 431 ttcaccaacg accagtacta cgtgtacttc ggcaccgtcc gcgactgcta tgaggccttg 60 gtcatctata atttcctgag cctgtgctat gagtacctag gaggagaaag ttccatcatg 120 tcggagatca gaggaaaacc cattgagtcc agctgtatgt atggcacctg ctgcctctgg 180 ggaaagactt attccatcgg atttctgagg ttctgcaaac aggccaccct gcagttctgt 240 gtggtgaagc cactcatggc ggtcagcact gtggtcctcc aggccttcgg caagtaccgg 300 gatggggact ttgacgtcac cagtggctac ctctacgtga ccatcatctg caacatctcc 360 gtcagcctgg ccctctacgc cctcttcctc ttctacttcg ccacccggga gctgctcagc 420 ccctacagcc ccgtcctcaa gttcttcatg gtcaagtccg tcatctttct ttccttctgg 480 caaggcatgc tcctggccat cctggagaag tgtggggcca tccccaaaat ccactcggcc 540 cgcgtgtcgg tgggcgaagg caccgtggct gccggctaca agacttcatc atctgtgtgg 600 anatgttctt tgcagccctg gccctgcggc acgccttcac ctacaaaggt ctatgctgac 660 aanaagctgg gacgcccnag ggccgctgtt gccccccatn aaanaacatc tccanc 716 <210> 432 <211> 652 <212> DNA <213> Homo sapiens <400> 432 gctggcgtgt tccgttaggt ctgagggagc gatggcggta cgcgcgttga agctgctgac 60 cacactgctg gctgtcgtgg ccgctgcctc ccaagccgag gtcgagtccg aggcaggatg 120 gggcatggtg acgcctgatc tgctcttcgc cgaggggacc gcagcctacg cgcgcgggga 180 ctggcccggg gtggtcctga gcatggaacg ggcgctgcgc tcccgggcag ccctccgcgc 240 ccttcgcctg cgctgccgca cccagtgtgc cgccgacttc ccgtgggagc tggaccccga 300 ctggtccccc agcccggccc aggcctcggg cgccgccgcc ctgcgcgacc tgagcttctt 360 cgggggcctt ctgcgtcgcg ctgcctgcct gcgccgctgc ctcgggccgc cggccgccca 420 ctcgctcagc gaagagatgg agctggagtt ccgcaagcgg agcccctaca actacctgca 480 ggtcgcctac ttcaagatca acaagttgga gaaagctgtt gctgcagcac acaccttctt 540 cgtgggcaat cctgagcaca tggaaatgca gcaganccta gactattacc aaaccatgtc 600 tggagtgaan gaggccgact tcaangatct tgagactcaa ccccatattc ca 652 <210> 433 <211> 802 <212> DNA <213> Homo sapiens <400> 433 gcacttcagc ttcccccccc ccggcgccct ctggggctcc gagcccggcg ggaccatgtt 60 caccagcacc ggctccagtg ggctctacaa ggcgcctctg tcgaagagcc ttctgctggt 120 ccccagtgcc ctctccctcc tgctcgccct cctcctgcct cactgccaga agctctttgt 180 gtatgacctt cacgcagtca agaacgactt ccagatttgg aggttgatat gtggaagaat 240 aatttgcctt gatttgaaag atactttctg cagtagtctg cttatttata attttaggat 300 atttgaaaga agatatggaa gcagaaaatt tgcatccttt ttgctgggtt cctgggtttt 360 gtcagcctta tttgactttc tcctcattga agctatgcag tatttctttg gcatcactgc 420 agctagtaat ttgccttctg gattcctggc acctgtgttt gctctgtttg taccatttta 480 ctgctccata ccaagagtcc aagtggcaca aattctgggt ccgttgtcca tcacaaacaa 540 gacattgatt tatatattgg gactgcagct tttcacctct ggttcctaca tctggattgt 600 agccataagt ggacttatgt ccggtctgtg ctacgacaag canaaatgtt ccaaggtgca 660 tcangtgctc tngcatcccc aagctgggaa tggcaaaatt ccttttcttg ggacaacttt 720 gaaaccccaa tccttctcct tcctcaagaa acccaaccaa gcggaaaagc cangaaattt 780 gggggnatgg gggaagnccc aa 802 <210> 434 <211> 413 <212> DNA <213> Homo sapiens <400> 434 cccgccgccc cggctgcgca cgcgacgccc cctccaggcc ccgctcctgc gccctatttg 60 gtcattcggg gggcaagcgg cgggagggga aacgtgcgcg gccgaagggg aagcggagcc 120 ggcgccggct gcgcagagga gccgctctcg ccgccgccac ctcggctggg agcccacgag 180 gctgccgcat cctgccctcg gaacaatggg actcggcgcg cgaggtgctt gggccgcgct 240 gctcctgagg acgctgcagg tgctagcgct gctgggggcc gcccatgaaa gcgcagccat 300 ggcggcatct gcaaacatag agaattctgg gcttccacac aactccagtg ctaactcaac 360 agagactctc caacatgtgc cttctgacca tacaaatgaa acttcccnca ntn 413 <210> 435 <211> 516 <212> DNA <213> Homo sapiens <400> 435 aggagacgct gcccttccgc agcgatggca tcccggctct gtggaggggc cctctggtat 60 gtgtgtccct gtccttctgg ggcgtggatg gtgcctggga cccagctggc aaccagttga 120 agacgttctc cttggaagct cttggccctg aggactttgc ctggggcatt ggccctgcca 180 tggcgttccg gagggccgag ggcacgtcta tgatccangc cctggccatg acggtggccg 240 agatccccgt gttcctgtac acgacgtttg ggcagtctgc attctcccag ctacggttga 300 cgccaggcct gcggaaagtc ctctttgcca cggccctggg gactgtggcc ctggccctgg 360 ctgcccacca gctgaagagg cgacnganga ggaagaagca ngttggtccc gagatgggag 420 gggagcagct gggcacggtg cccctcccta tcctcttggc cangaaggtc ccttcagtga 480 agaaaggata ctcnagccgg agagtcnana gnccca 516 <210> 436 <211> 588 <212> DNA <213> Homo sapiens <400> 436 tcatcacgga cgtggactac ctgcatcaca agtacccagg gacctccatc gtgtttgaca 60 tgagcctcac ctacatcttg gtggcactgg cagctgtcct cctgaacaac gtcctggtgg 120 agagactgac cctgcacacc aggatcaccg caggctacct cttagccttg ggccctctcc 180 tttttatcag catctgcgac gtgtggctgc agctcttctc tcgggaccag gcctacgcca 240 tcaacctggc cgctgtgggc accgtggcct tcggctgcac agtgcagcaa tccagcttct 300 acgggtacac ggggatgctg cccaagcggt acacgcaggg ggtgatgacc ggggagagca 360 cggcgggcgt gatgatctct ctgagccgca tcctcacgaa gctgctgctg cccgacgagc 420 gcgccagcac gctcatcttc ttcctggtgt cggtggcgct ggagctgctg tgtttcctgc 480 tgcacctgtt agtgcggcgc aacgcttcgt gctcttccat accacacggg cgcgtgacag 540 ccaccggggc anggcangcc tgggnaaggg ctatggntac cgcgtgna 588 <210> 437 <211> 740 <212> DNA <213> Homo sapiens <400> 437 acgcgcccag acggccgcga tggcgctgtt ggccggcggg ctctccagag ggctgggctc 60 ccacccggcc gccgcaggcc gggacgcggt cgtcttcgtg tggcttctgc ttagcacctg 120 gtgcacagct cctgccaggg ccatccaggt gaccgtgtcc aacccctacc acgtggtgat 180 cctcttccag cctgtgaccc tgccctgtac ctaccagatg acctcgaccc ccacgcaacc 240 catcgtcatc tggaagtaca agtctttctg ccgggaccgc atcgccgatg ccttctcccc 300 ggccagcgtc gacaaccagc tcaatgccca gctggcagcc gggaacccag gctacaaccc 360 ctacgttgag tgccaggaca gcgtgcgcac cgtcagggtc gtggccacca agcagggcaa 420 cgctgtgacc ctgggagatt actaccaagg gccggaggat taccatcacc ggaaatgctg 480 acctgacctt tgaccagacg gcgtgggggg acagtggtgt gtattactgc tccgtggtct 540 cagcccagga cctccagggg aacaatgang cctacgcaga agctcatcgt ccttgactgg 600 ctcttcgtgg ttgtggtatg cctggctgcc ttcctcatct tcctcctcct gggcatctgc 660 tgggtgccan tgctgcccgc acaactttct gctgctantt caggttgccc ctgctgccaa 720 nacaantgnt gctgccccca 740 <210> 438 <211> 736 <212> DNA <213> Homo sapiens <400> 438 acggtggccg gagcagccgg aagctagcat ggcggccgcc ggggctgcgg ctacacacct 60 agaggtggcc cggggcaagc gcgccgccct cttcttcgct gcggtggcca tcgtgctggg 120 gctaccgctc tggtggaaga ccacggagac ctaccgggcc tcgttgcctt actcccagat 180 cagtggcctg aatgcccttc agctccgcct catggtgcct gtcactgtcg tgtttacgcg 240 ggagtcagtg cccctggacg accaggagaa gctgcccttc accgttgtgc atgaaagaga 300 gattcctctg aaatacaaaa tgaaaatcaa atgccgtttc cagaaggcct atcggagggc 360 tttggaccat gaggaggagg ccctgtcatc gggcagtgtg caagaggcag aagccatgtt 420 agatgagcct caagaacaag cggagggctc cctgactgtg tacgtgatat ctgaacactc 480 ctcacttctt ccccaggaca tgatgagcta cattgggccc aagangacag cantggtgcn 540 ggggataatg caccgggagg gctttaacat cattggccgc cgcatagtcc aagtggccca 600 agccatgtct ttgactgang atgtgcttgc tgctgctctg gntgaccacc ttccaaaggg 660 acaagtggan cgcttaaaan aggcggnctc tcaagtccaa cttgggctat gagatcacct 720 caatttantc aaccaa 736 <210> 439 <211> 725 <212> DNA <213> Homo sapiens <400> 439 aaaaagaaag ggctggcgaa gtcgaaaggc gaggcggccg cggcagcgct tgggacgcgc 60 ctgggcaccg ggctcgctcc ctgcgccccg gagcaggcca agttcggggc caggacgtcg 120 ggaggacctg gtgcatggct gcctcctaat cccatagtcc agaggaggca tccctaggac 180 tgcgggcaag ggagccgggc aagcccaggg cagccttgaa ccgtcccctg gcctgccctc 240 cccggtgggg gccaggatgc tgaagaagca gtctgcaggg cttgtgctgt ggggcgctat 300 cctctttgtg gcctggaatg ccctgctgct cctcttcttc tggacgcgcc cagcacctgg 360 caggccaccc tcagtcagcg ctctcgatgg cgaccccgcc agcctcaccc aggtcttccg 420 gcagtttcgc ttccccgcgg ccgtggtggt ggaggatgac ctggaggtgg ccccggactt 480 cttcgagtac tttcaggcca cctatccgct gctgaaggcc gacccctccc tgtggtgcgt 540 ctcggcctgg aaatgacaac ggcaaggagc agatggtgga cgccagcaag cctgaactgc 600 tctaccgcac cgactttttc cctgggcctg gggctgggct gctgttggcc ganctctggg 660 cttaagctgg agcccaantg ggcaaaangc cttctgggaa cnactgggat tccggnggcc 720 cggga 725 <210> 440 <211> 794 <212> DNA <213> Homo sapiens <400> 440 ttctctcacc gggactcggg actcccggga agtggaccgg cagaagaggg ggctagctag 60 ctgtctctgc ggaccaggga gacccccgcg cccccccggt gtgaggcggc ctcacagggc 120 cgggtgggct ggcgagccga cgcggcggcg gaggaggctg tgaggagtgt gtggaacagg 180 acccgggaca gaggaaccat ggctccgcag aacctgagca ccttttgcct gttgctgcta 240 tacctcatcg gggcggtgat tgccggacga gatttctata agatcttggg ggtgcctcga 300 agtgcctcta taaaggatat taaaaaggcc tataggaaac tagccctgca gcttcatccc 360 gaccggaacc ctgatgatcc acaagcccag gagaaattcc aggatctggg tgctgcttat 420 gaggttctgt cagatagtga gaaacggaaa cagtacgata cttatggtga agaaggatta 480 aaagatggtc atcagagctc ccatggagac attttttcac acttctttgg ggattttggt 540 ttcatgtttg gaggaaccct cgtcagcaag acagaaatat tccaagagga agtgatatta 600 ttgtanatct aaaagtcact tttgggaaga agtatatnca aggaaatttt tgtgggaaag 660 tagttaagaa acaaaaccct gtgggcaaag gcaaggctcc tgggcaaaac gggaagttgc 720 naatttgtcc cggnaaagag nattccgggn ccaacccaaa cttggggccc cctggggcgc 780 ntttccaaaa attg 794 <210> 441 <211> 761 <212> DNA <213> Homo sapiens <400> 441 ggtgactggg tggggctgcc tcacttctgc ctgatttggg aagcgctgca aggacaaccg 60 gctggggtcc ttgcgcgccg cggctcaggg aggagcaccg actgcgccgc accctgagag 120 atggttggtg ccatgtggaa ggtgattgtt tcgctggtcc tgttgatgcc tggcccctgt 180 gatgggctgt ttcgctccct atacagaagt gtttccatgc cacctaaggg agactcagga 240 cagccattat ttctcacccc ttacattgaa gctgggaaga tccaaaaagg aagagaattg 300 agtttggtcg gccctttccc aggactgaac atgaagagtt atgccggctt cctcaccgtg 360 aataagactt acaacagcaa cctcttcttc tggttcttcc cagctcagat acagccagaa 420 gatgccccag tagttctctg gctacanggt gggccgggag gttcatccat gtttggactc 480 tttgtggaac atgggcctta tgttgtcaca agtaacatga ccttgcgtga cagagacttc 540 ccctggacca caacgctctc catgctttac attgacaatc cagtgggcac aagcttcant 600 tttactgatg atacccacgg gtattcagtc aatgaggacg atgtagcacg gggatttata 660 cagtggcact aattcagttt ttccaganat ttccgganta taaaaataan gacttttang 720 tcactgggga atcttatcag ggaaatatgt gcancccatt g 761 <210> 442 <211> 739 <212> DNA <213> Homo sapiens <400> 442 aaaactcttt cttcggctcg cgagctgaga ggagcaggta gaggggcaga ggcgggactg 60 tcgtctgggg gagccgccca ggaggctcct caggccgacc ccagaccctg gctggccagg 120 atgaagtatc tccggcaccg gcggcccaat gccaccctca ttctggccat cggcgctttc 180 accctcctcc tcttcagtct gctagtgtca ccacccacct gcaaggtcca ggagcagcca 240 ccggcgatcc ccgaggccct ggcctggccc actccaccca cccgcccagc cccggccccg 300 tgccatgcca acacctctat ggtcacccac ccggacttcg ccacgcagcc gcagcacgtt 360 cagaacttcc tcctgtacag acactgccgc cacctcttcg tggggcaact gatccaaaac 420 gtgggcccca tccgggcttt ttggagcaag tactatgtgc cagaggtggt gactcagaat 480 gagcggtacc caccctattg tgggggtggt ggcttcttgc tgtcccgctt cacggccgct 540 gccctgcgcc gtgctgccca tgtcttggnc atcttcccca ttgatgatgt cttcctgggt 600 atgtgtctgg agcttgaggg actgaagcct gcctcccaca gcgggatccg cacgtctggc 660 gtncgggctc catcncaacg nctgtcctcc tttgaccctg gttcaacgag acctgctgct 720 gggnaacgct tccanctta 739 <210> 443 <211> 736 <212> DNA <213> Homo sapiens <400> 443 agaagaggag aagaggttgt gtgggacaag ctgctcccga cagaaggatg tcgctgctga 60 gcctgccctg gctgggcctc agaccggtgg caatgtcccc atggctactc ctgctgctgg 120 ttgtgggctc ctggctactc gcccgcatcc tggcttggac ctatgccttc tataacaact 180 gccgccggct ccagtgtttc ccacagcccc caaaacggaa ctggttttgg ggtcacctgg 240 gcctgatcac tcctacagag gagggcttga aggactcgac ccagatgtcg gccacctatt 300 cccagggctt tacgctgcca ttgcacccaa ggataatctc ttcatcaggt tcctgaagcc 360 ctggctgggt gagtacctgc aggtgaaagg ggttggggac aaccttgcgg ggagggtagg 420 ggaagtgctg ctcttgccca ttgtccttgg ctgccctact aggagaaggg atactgctga 480 gtggcggtga caagtggagc cgccaccgtc ggatgctgac gcccgccttc catttcaaca 540 tcctgaagtc ctatataacg atcttcaaca agagtgcaaa catcatgctt gacaagtggc 600 aacacctggc ctcagagggc aacantcgtc tggacatgtt tgagcacatc agcctcaatg 660 accttggnca gtctaaaaga aaatgcatcc ttcaagcntt tgnacagcca attgtcaagg 720 aanaaggccc aanttg 736 <210> 444 <211> 860 <212> DNA <213> Homo sapiens <400> 444 atggcgcccc tcagaacaac tgtattgctg tggagcctct tgaggagttc tccgggcgtg 60 gaacgggtct gtttccgggc tcgaatccag ccctggcacg gtggcctgct ccaaccgcta 120 ccttgctctt tcgagatggg gctgccacgc cgccggttca gctccgaggc cgcagaatct 180 ggtagcccag agaccaagaa acctacattt atggatgagg aagttcaaag catactcacg 240 aaaatgacag gcttgaactt gcagaagact tttaagccag ctatacaaga actgaagcca 300 ccaacctata agctaatgac tcaggcacag ttggaagagg ctacaagaca ggcagttgag 360 gcagctaaag tacgattaaa aatgccacca gttctggaag agcgagtacc aataaatgat 420 gtgttagctg aagataagat tttggaagga acagaaacaa ccaaatatgt gtttactgat 480 atatcatata gcataccaca ccgggagcgt tttattgtcg tcagagaacc aagtggcaca 540 ctacgcaaag cctcttggga agaacgggac cgaatgatac aagtttattt cccaaaagaa 600 ggtcgtaaaa ttttgacacc aataattttc aaggaagaaa atcttanggt aaggtgacnt 660 angttttaag ttttagagcc agtggtgatg atttatttgt agaaccaatt ggctttgtgc 720 cntgatccan ataaacattt ctaatgataa cttgactttt tttttttttg naaatggagt 780 tcgccccctt tgccaaggct gaagttcaat tgcggggatn tcaactcann gnaaacctcc 840 aaccttcggg tttcaagggg 860 <210> 445 <211> 768 <212> DNA <213> Homo sapiens <400> 445 atcagacctg agcagttgct ccggcggcgc tcggggaggg agccagcagc ctagggccta 60 ggcccgggcc accatggcgc tgcctccagg cccagccgcc ctccggcaca cactgctgct 120 cctgccagcc cttctgagct caggttgggg ggagttggag ccacaaatag atggtcagac 180 ctgggctgag cgggcacttc gggagaatga acgccacgcc ttcacctgcc gggtggcagg 240 ggggcctggc acccccagat tggcctggta tctggatgga cagctgcagg aggccagcac 300 ctcaagactg ctgagcgtgg gaggggaggc cttctctgga ggcaccagca ccttcactgt 360 cactgcccat cgggcccagc atgagctcaa ctgctctctg caggacccca gaagtggccg 420 atcagccaac gcctctgtca tccttaatgt gcaattcaag ccagagattg cccaagtcgg 480 cgccaagtac caggaagctc agggcccagg cctcctggtt gtcctgtttg ccctggtgcg 540 tgccaacccg ccggncaatg tcacctggat cgaccaggat gggccagtga ctgtcaacac 600 ctctgacttc ctggtgctgg ntgccanaac taccctggtc acaaccacac gtgcanctgc 660 agctccgcag cctggcanaa acctctcggt ggtggcacaa atgacttggt gtcacaatgc 720 ttgctccagc cccaggccct cccgggaacc atctctggta tncagnnn 768 <210> 446 <211> 677 <212> DNA <213> Homo sapiens <400> 446 aagcgacgac ttccgccctc cttagggccg tggtcccgta gctaccggtc gcgtcgccgt 60 gggcgacgtg cccgcttcca aaatggcggc ggcggcggta tctggtgcgc ttggccgggc 120 gggctggagg ctcctgcagc tgcgatgcct gcccgtggcc cgttgccgac aagccctggt 180 gccgcgtgcc ttccatgctt cagctgtggg gctaaggtct tcagatgagc agaagcagca 240 gcctcccaac tcattttctc agcagcattc tgagacacag ggcgcagaaa aacctgatcc 300 agagtcttct cattcacccc ccaggtatac agaccagggc ggcgaggagg aggaggacta 360 tgaaagtgag gagcagttgc agcaccgcat cctgacggca gcccttgaag tttgtgcccg 420 cccacgggtg gacagcagag gcgattgcag aaggagccca agtgtgtata ngtgagggtg 480 gggccaccta accaagatga gccaggatgg agtcacacca aggcagagcg ggggggcctc 540 atgccttctt ccagtctagc tcagagcccc tcacagctgc aagattgact ggtttttttc 600 ccccaatagg gtgggaactg gctttanttt tgtnngttta aaaagaacaa taccatgggn 660 agttgggntc cttggga 677 <210> 447 <211> 898 <212> DNA <213> Homo sapiens <400> 447 agttgagaga tggcggccgc cgcaggtaga tcgctcctgc tgctcctctc ctctcggggc 60 ggcggcggcg ggggcgccgg cggctgcggg gcgctgactg ccggctgctt ccctgggctg 120 ggcgtcagcc gccaccggca gcagcagcac caccggacgg tacaccagag gatcgcttcc 180 tggcagaatt tgggagctgt ttattgcagc actgttgtgc cctctgatga tgttacagtg 240 gtttatcaaa atgggttacc tgtgatatct gtgaggctac catcccggcg tgaacgctgt 300 cagttcacac tcaagcctat ctctgactct gttggtgtat ttttacgaca actgcaagaa 360 gaggatcggg gaattgacag agttgctatc tattcaccag atggtgttcg cgttgctgct 420 tcaacaggaa tagacctcct cctccttgat gactttaagc tggtcattaa tgacttaaca 480 taccacgtac gaccaccaaa aagagacctc ttaagtcatg aaaatgcagc aacgctgaat 540 gatgtaaaga cattggtcca gcagctatac accacactgt gcattgaagc agcaccagtt 600 aaacanggaa agggagctta ttgaaagact agaggatctc aaaagagcaa ctggctcccc 660 tggaaaaggt acgaattgag attagcagaa aagctganga anaagggacc actttggngc 720 caatgggtgg ccttgcctac aatggcaaaa cagttttggc atttttggnc ccggntttac 780 cctgggtggg gaaatattcc ctggggaaca atcatgggng ccaagttaac aatactttca 840 ancaacttta tgggaattng ccaatgggca aantgttagg caataaattt tgttaang 898 <210> 448 <211> 607 <212> DNA <213> Homo sapiens <400> 448 attgtgtctg gcggcggcgc gcgagcccac cggcggctgc ggcggggcgg gaagccatgg 60 agccgcgggc gctcgtcacg gcgctcagcc tcggcctcag cctgtgctcc ctggggctgc 120 tcgtcacggc catcttcacc gaccactggt acgagaccga cccccggcgc cacaaggaga 180 gctgcgagcg cagccgcgcg ggcgccgacc ccccggacca gaagaaccgc ctgatgccgc 240 tgtcgcacct gccgctgcgg gactcgcccc cgctggggcg ccggctgctc ccgggcggcc 300 cggggcgcgc cgaccccgag tcctggcgct cgctcctggg gctcggnggg ctggacgccg 360 agtgcggccg gcccctcttc gccacctact cgggcctctg gaggaagtgc tacttcctgg 420 gcatcgaccg ggacatcgac accctcatcc tgaaaggtat tgcgcancga tgcacggcca 480 tcaagtacca cttttctcaa gcccatccgc ttgcgaaaca ttccttttaa tttaaccaag 540 ancatacagc aagatgantt ngcacctgct tcatttaaga atnatcactg ctggntttcc 600 tcggcat 607 <210> 449 <211> 735 <212> DNA <213> Homo sapiens <400> 449 gcggatcact gaggctgtgg cggcactgcg cccggcgctc gcgtccgtcc gcccgtccgc 60 ccgcccagcc atgactgcgc cggtccccgc gccgcggatc ctgttgccgt tgctgttgct 120 gctgctgcta acgccgcctc cgggtgcacg tggtgaggtg tgtatggctt cccgtggact 180 cagcctcttc cccgagtcct gtccagattt ctgctgtggt acctgtgatg accaatactg 240 ctgctctgac gtgctgaaga aatttgtgtg gagcgaggaa aggtgtgctg tgcctgaggc 300 cagcgtgcct gccagtgtag agccggtgga gcagctgggc tcggcgctga ggtttcgccc 360 tggctacaac gaccccatgt cagggttcgg agcgaccttg gccgttggcc tgaccatctt 420 tgtgctgtct gtcgtcacta tcatcatctg cttcacctgc tcctgctgct gcctttacaa 480 gacgtgccgc cgaccacgtc cggttgtcac caccaccaca tccaccactg tggtgcatgc 540 cccttatcct cagcctccaa gtgtgcccgc ccagctaccc tggaccaagc taccaagggc 600 taccacacca tgccgcctca gccagggatg ccaacaagca ccctanccaa tgcaagtacc 660 cancacctta cccaacccan cccatgggcc caacggccta acaacaaaac cctgggctgg 720 ganggagcaa ccgng 735 <210> 450 <211> 713 <212> DNA <213> Homo sapiens <400> 450 gatataaaat aactgaaatc tggaactaat caactgtgaa aatcaagcaa cgagaaagag 60 ttgtaaatta ttttaaaata tctggctcga tcaactttgc cagttttaga gccagtcttt 120 gcaaaaaggg agaaacaaaa cagatgagac aagaaaggaa catccagcat gctgtgaacc 180 ccctgagact ggccatgatc tgaaagagta aagctctatc cagggaacct tttctgaatc 240 atagtgtcag acttcctgct cttttcaact cccctggttt tatcatctct actctgtttc 300 agcaatctac tgccatggcc acatcctgaa tgttgacaat accctaaact gtgccattta 360 taagatctct gacacaccaa cctctctcct cttacagctc tcaatgatgt atatgacctc 420 agcttattct aatatgctta cagattatac acccgtgata ttgatggcag tggctgctgc 480 tgtcgtggct gctgctatca cgcctgctgc aacacagagg tgcgactggg gctgcacatt 540 tcacggaggt gttgggagtt ccgccccttc tgatgtgggg aaagagattc ccaggtgccc 600 ctgcatctgc ccaaactgtg gctgtggatc ggaggctcca ngttggnang gttgggagct 660 tccgggtgca nctgcgaacg gcctcccaag gtgcaaggac cctggngttt ctg 713 <210> 451 <211> 716 <212> DNA <213> Homo sapiens <400> 451 attcatttcc cccagtgacc ttgacaagtc agaagcttga aagcagggaa atccggatgt 60 ctcggttatg aagtggagca gtgagtgtga gcctcaacat agttccagaa ctctccatcc 120 ggactagtta ttgagcatct gcctctcata tcaccagtgg ccatctgagg tgtttccctg 180 gctctgaagg ggtaggcacg atggccaggt gcttcagcct ggtgttgctt ctcacttcca 240 tctggaccac gaggctcctg gtccaaggct ctttgcgtgc agaagagctt tccatccagg 300 tgtcatgcag aattatgggg atcacccttg tgagcaaaaa ggcgaaccag cagctgaatt 360 tcacagaagc taaggaggcc tgtaggctgc tgggactaag tttggccggc aaggaccaag 420 ttgaaacagc cttgaaagct agctttgaaa cttgcagcta tggctgggtt ggagatggat 480 tcgtggtcat ctctaggatt agcccaaacc ccaagtgtgg gaaaaatggg gtgggtgtcc 540 tgatttggaa ggttccagtg agccgacagt ttgcaaccta ttgttacaac tcatctgata 600 cttggnctaa ctcgtgcatt ccagaaatta tcaccancaa agatccatat tcaacactca 660 aactggaaac acaanacnac aaaatttatt gncagtgaca gtacctactc gggngg 716 <210> 452 <211> 590 <212> DNA <213> Homo sapiens <400> 452 ctgcagtagg tctgccggcg atggagtggt gggctagctc gccgcttcgg ctctggctgc 60 tgttgttcct cctgccctca gcgcagggcc gccagaagga gtcaggttca aaatggaaag 120 tatttattga ccaaattaac aggtctttgg agaattacga accatgttca agtcaaaact 180 gcagctgcta ccatggtgtc atanaagagg atctaactcc tttccgagga ggcatctcca 240 ggaagatgat ggcagaggta ntcagacgga agctagggac ccactatcag ntcactaaga 300 acagactgta ccgggaaaat gactgcatgt tcccctcaag gtgtagtggt gttgagcact 360 ttattttgga antgatcggg cgtctccctg anatgganat ggtgatcaat gtacgagatt 420 atcctcaggt tcctaaatgg atggagcctg ccatccnagt cttctccttn agtaagacat 480 cagagtacca tgatatcatg tatcctgctt ggaacatttt gggaaagggg gacctgctgt 540 ttggccantt tancctaana ggtcttggac ggtggganct cttcanagaa 590 <210> 453 <211> 750 <212> DNA <213> Homo sapiens <400> 453 gactgggttc gcggccgcgt gcagaggtgc aggcagagca gcctcggaac cgagacgatg 60 cgtgcgctcc gcgaccgagc cgggctcctc ctctgcgtgc tgctgctggc ggcgctgctg 120 gaggcggcgc tagggctccc cgtgaagaag ccgcggctcc gcggaccacg gcctgggagc 180 ctcacgaggc tcgcagaggt ctcagcctcc ccagatccta ggcctctgaa ggaagaggag 240 gaggcaccac tgctccccag aacccacctg caggcagagc cacaccaaca tggatgctgg 300 actgtcactg agccagcagc catgacccca ggcaacacca cccctcccag gaccccagag 360 gttactccgt tgcggctgga gctgcagaag ctgccgggat tggccaagca caaccttgag 420 tacccctaac cctgataccc aggcttcagc ctccccagat cctangcctc tgagggaaga 480 ggaggaggca cgactgctcc ccagaaccca cctgcaggca agagctacac caacatggat 540 gttggactgt cactgagcca gcagccctga ccccagggaa tgccacgcct cccaaggacc 600 caagangtta ctcccttgct gctggagctg caagaaagct gccagaaatt ggtccacgca 660 aaccttgagt tanccctaaa cctgataacc aaggtgacca atcaaaggtt ngtggaaggg 720 aacccccaag ggccnaaggt ngtccnatta 750 <210> 454 <211> 740 <212> DNA <213> Homo sapiens <400> 454 tggcggtggc gcggtagcgc gcgatgcagc acaggctaag aggctgcgca agcgcggggc 60 ccgcccctgg gaccctccgg gccgggcggt ttggcccctt agcgcccggg cgtcggggcg 120 gtaaaaggcc ggcagaaggg aggcacttga ggacccaagt ttcttcacca tggggatgtg 180 gtccattggt gcaggagccc tgggggctgc tgccttggca ttgctgcttg ccaacacaga 240 cgtgtttctg tccaagcccc agaaagcggc cctggagtac ctggaggata tagacctgaa 300 aacactggag aaggaaccaa ggactttcaa agcaaaggag ctatgggaaa aaaatggagc 360 tgtgattatg gccgtgcgga ggccaggctg tttcctctgt cgagaggaag ctgcggatct 420 gtcctccctg aaaagcatgt tggaccagct gggcgtcccc ctctatgcag tggtaaagga 480 gcacatcagg actgaagtga aggatttcca gccttatttc aaaggagaaa tcttcctgga 540 tgaaaagaaa aagttctatg gtccacaaag gcgggaagat gatgtttatg ggatttatcc 600 gtctgggaat gtggtacaac ttcttccgag cctggaacgg aggcttctct gggaaacctg 660 gaangganaa ggcttcatcc ttgggggant tttcgtggtg ggatnaagga aaacaagggc 720 aattcttcnt gagcaccgag 740 <210> 455 <211> 699 <212> DNA <213> Homo sapiens <400> 455 atgcgggttc tgcttccaaa gccatctctt ccagcaggag agggctctac tctgagctcc 60 tattttccaa ggctccgggc cgcgctcggc gctggcctgc tgccccggcg ggtccgccgg 120 ccggaggcgg gagtcacagg aagagccctc cacaaaagga ggcctcggcg gatcaggaca 180 gctgcaggtg ggtgtgcaga ctggtgagct gccagcaggg gcccagacgc gccaggcctg 240 gagatggctg gaaactgctc ctgggaggcc catcccggca acaggaacag gatgtgccct 300 ggcctgagcg aggccccgga actctacagc cggggcttcc tgaccatcga gcagatcgcg 360 atgctgccgc ctccggccgt catgaactac atcttcctgc tcctctgcct gtgtggcctg 420 gtgggcaacg ggctggtcct ctggtttttc ggcttctcca tcaagaggaa ccccttctcc 480 atctacttcc tgcacctggc cagcgccgat gtgggctacc tcttcagcaa ggcggtgttc 540 tccatcctga acacgggggg cttcctgggc acgtttgccg actacatccg cagcgtgtgc 600 cgggtcctgg ggctctgcat gttccttacc ggngtgaagc ctcctgccgg gcgtcagcgc 660 cgaagcgctg cgcctcggtc aacntccccg cctggtnat 699 <210> 456 <211> 783 <212> DNA <213> Homo sapiens <400> 456 atctttattg aaatgtattt catcttcacg tctttctggg catataagat ctattatgtc 60 tatggcttca tgatgctggt gctggttatc ctgtgcattg tgactgtctg tgtgactatt 120 gtgtgcacat attttctact aaatgcagaa gattacaggt ggcaatggac aagttttctc 180 tctgctgcat caactgcaat ctatgtttac atgtattcct tttactacta ttttttcaaa 240 acaaagatgt atggcttatt tcaaacatca ttttactttg gatatatggc ggtatttagc 300 acagccttgg ggataatgtg tggagcgatt ggttacatgg gaacaagtgc ctttgtccga 360 aaaatctata ctaatgtgaa aattgactag agacccaaga aaacctggaa ctttggatca 420 atttcttttt cataggggtg gaacttgcac agcaaaaaca aacaaacgca agaagagatt 480 tgggctttaa cacactgggt actttgtggg tctctctttc gtcggtggct taaagtaaca 540 tctatttcca ttgatcctan gttcttcctg actgctttct ccaactgttc acagcaaatg 600 cttggatttt atgcagtagg cattactaca gtacatggct aatcttccca aaaaactagc 660 tcattaaaga tgaaatagac cagctctctt caatgaagan gacaaatagt ttatttaaag 720 canttgttcc aataaagata aatanaggga aacttggatg ctaaaattac atgaataggg 780 aat 783 <210> 457 <211> 720 <212> DNA <213> Homo sapiens <400> 457 tctcttcggc ttccgtagag gaagtggcgc ggaccttcat ttggggtttc ggttcccccc 60 cttccccttc cccggggtct gggggtgaca ttgcaccgcg cccctcgtgg ggtcgcgttg 120 ccaccccacg cggactcccc agctggcgcg cccctcccat ttgcctgtcc tggtcaggcc 180 cccacccacc ttcccacctg accagccatg ggggctgcgg tgttttgcgg ctgcactttc 240 gtcgcgttcg gcccggcctt cgcgcttttc ttgatcactg tggctgggga cccgcttcgc 300 gttatcatcc tggtcgcagg ggcatttttc tggctggtct ccctgctcct ggcctctgtg 360 gtctggttca tcttggtcca tgtgaccgac cggtcagatg cccggctcca gtacggcctc 420 ctgatttttg gtgctgctgt ctctgtcctt ctacaggagg tgttccgctt tgcctactac 480 aagctgctta agaaggcaga tgaggggtta gcatcgctga gtgaggacgg aagatcaccc 540 atctccatcc gccagatggc ctatgtttct ggtctctcct tcggtatcan cagtggtgtc 600 ntctctgtta acaagtattt tggctgaatg caacttgggc caaagttgtg gttggggaat 660 ccaatgggag actcaaccct aattaacttc cccggaantt tcaanccttt tccnggaaca 720 <210> 458 <211> 596 <212> DNA <213> Homo sapiens <400> 458 gcgctgctgt ggcggccgct gtagcagcgg cggtccagtc gtagcccggc cgcccgcgcc 60 tgtccggtcc ggtccggcca cggaggcagc gcagcggcgg gactccgagc ctaccccgcc 120 gagtgagctg cgccgcaccg tgccgtccca cccggcaccc accagtccga tggggccgca 180 gcggcggctg tcccctgccg gggccgccct actctggggc ttcctgctcc agctgacagc 240 cgctcaggaa gcaatcttgc atgcgtctgg aaatggcaca accaaggact actgcatgct 300 ttataaccct tattggacag ctcttccaag taccctagaa aatgcaactt ccattagttt 360 gatgaatctg acttccacac cactatgcaa cctttctgat attcctcctg ttggcataaa 420 gagcaaagca gttgtggttc catggggaag ctgccatttt cttgaaaaag ccagaattgc 480 acagaaagga ggtgctgaag caatgttagt tgtcantaac agtgtcctat ttcctccctc 540 angtaacaga tctgaatttc ctgatgttaa aatactgatt gcatttatna gctaca 596 <210> 459 <211> 810 <212> DNA <213> Homo sapiens <400> 459 gctcctggag gcggcggcgg gagcgcaggg ggcgcgcggc ccggggactc gcattccccg 60 gttccccctc caccccacgc ggcctggacc atggacgcca gatggtgggc agtggtggtg 120 ctggctgcgt tcccctccct aggggcaggt ggggagactc ccgaagcccc tccggagtca 180 tggacccagc tatggttctt ccgatttgtg gtgaatgctg ctggctatgc cagctttatg 240 gtacctggct acctcctggt gcagtacttc aggcggaaga actacctgga gaccggtagg 300 ggcctctgct ttcccctggt gaaagcttgt gtgtttggca atgagcccaa ggcctctgat 360 gaggttcccc tggcgccccg aacagaggcg gcagagacca ccccgatgtg gcaggccctg 420 aagctgctct tctgtgccac agggctccag gtgtcttatc tgacttgggg tgtgctgcag 480 gaaagagtga tgacccgcag ctatggggcc acaagccaca tcaccgggtg agcgctttac 540 ggactcgcag ttcctggtgc taatgaaccg agtgctggca ctgattgtgg ctggcctctc 600 ctgtgttctc tgcaagcagc cccggcatgg ggcacccatg taccggtact cctttgcaac 660 ctgtccaatg tgcttaacan ctggtgccaa tacaaagctc ctaagttcgt cagcttccca 720 accaagtgct ggccaaggcc tctaagggat cctgtatgct gatgggaaan cttgtgtctc 780 ggngcaacta caacactggg agtactgana 810 <210> 460 <211> 681 <212> DNA <213> Homo sapiens <400> 460 gcaccccagc cagtttgcca tggggggcgc cttctccagc atggcggccg ctggcatggg 60 tcccctcctg gccacggttt ctggggcctc caccggtgtc tcgggcctgg attccacggc 120 catggcctct gccgctgcgg cgcagggact gtccggggcg tccgcggcca ccctgccctt 180 ccacctccag cagcacgtcc tggcctctca gggcctggcc atgtcccctt tcggaagcct 240 gttcccttac ccctacacgt acatggccgc agcggcggcc gcctcctctg cggcagcctc 300 cagctcggtg caccgccacc ccttcctcaa tctgaacacc atgcgcccgc ggctgcgcta 360 cagcccctac tccatcccgg tgccggtccc ggacggcagc agtctgctca ccaccgccct 420 gccctccatg gcggcggccg cggggcccct ggacggcaaa gtcgccgccc tggccgccag 480 cccggcctcg gtggcagtgg actcgggctc tgaactcaac agccgctcct ccacgctctc 540 ctccagctcc atgtccttgt cgcccaaact ctgcgcggag aaagaggcgg gcaccagcga 600 actgcanagc atccancggt tggttagcgg cttggaagcc aagccggaca ngtcccgcaa 660 cgcgtcccgt agacccgtcc a 681 <210> 461 <211> 707 <212> DNA <213> Homo sapiens <400> 461 agcgctcccg aggccgcggg agcctgcaga gaggacagcc ggcctgcgcc gggacatgcg 60 gccccaggag ctccccaggc tcgcgttccc gttgctgctg ttgctgttgc tgctgctgcc 120 gccgccgccg tgccctgccc acagcgccac gcgcttcgac cccacctggg agtccctgga 180 cgcccgccag ctgcccgcgt ggtttgacca ggccaagttc ggcatcttca tccactgggg 240 agtgttttcc gtgcccagct tcggtagcga gtggttctgg tggtattggc aaaaggaaaa 300 gataccgaag tatgtggaat ttatgaaaga taattaccct cctagtttca aatatgaaga 360 ttttggacca ctatttacag caaaattttt taatgccaac cagtgggcag atatttttca 420 ggcctctggt gccaaataca ttgtcttaac ttccaaacat catgaaggct ttaccttgtg 480 ggggtcagaa tattcgtgga actggaatgc catagatgan gggcccaaga gggacattgt 540 caaggaactt gaggtagcca ttaggaacag aactgacctg cgttttggac tgtacattcc 600 ctttttgaat ggtttcatcc gctcttcctt ganggatgaa tccagttcat tccaataang 660 cggnaatttc caagtttcca aagacattgc caaaagctcc tatgaag 707 <210> 462 <211> 694 <212> DNA <213> Homo sapiens <400> 462 acatggcccg cgggacaaca tggctgcgcc cgcactaggg ctggtgtgtg gacgttgccc 60 tgagctgggt ctcgtcctct tgctgctgct gctctcgctg ctgtgtggag cggcagggag 120 ccaggaggcc gggaccggtg cgggcgcggg gtcccttgcg ggttcttgcg gctgcggcac 180 gccccagcgg cctggcgccc atggcagttc ggcagccgct caccgatact cgcgggaggc 240 taacgctccg ggccccgtac ccggagagcg gcaactcgcg cactcaaaga tggtccccat 300 ccctgctgga gtatttacaa tgggcacaga tgatcctcag ataaagcagg atggggaagc 360 acctgcgagg agagttacta ttgatgccct ttacatggat gcctatgaag tcagtaatac 420 tgaatttgag aagtttgtga actcaactgg ctatttgaca gaggctgaga agtttggcga 480 ctcctttgtc tttgaaggca tgttgagtga gcaagtgaag accaatattc aacangcagt 540 tgcagctgct ccctggtggt tacctgtgaa aggcgctaac tggagacacc cagaanggcc 600 tgactctact aatctgcaca aggccggatn atccaattct ccaagtgtcc tggaaatgat 660 gcnggttgcc taatgcactt gggcaaggga aaac 694 <210> 463 <211> 687 <212> DNA <213> Homo sapiens <400> 463 ctgtcagcgc ctttgtgagg agaaatgtgg ctgtctacta cgtgtcctat gctgtcttcg 60 ttgtcaccta cctgatcctt gcctgctgcc agggacccag acgccgtttc ccatggaaca 120 tcattctgct gacccttttt acttttgcca tgggcttcat gacgggcacc atttccagta 180 tgtaccaaac caaagccgtc atcattgcaa tgatcatcac tgcggtggta tccatttcag 240 tcaccatctt ctgctttcag accaaggtgg acttcacctc gtgcacaggc ctcttctgtg 300 tcctgggaat tgtgctcctg gtgactggga ttgtcactag cattgtgctc tacttccaat 360 acgtttactg gctccacatg ctctatgctg ctctgggggc catttgtttc accctgttcc 420 tggcttacga cacacagctg gtcctgggga accggaagca caccatcagc cccgaggact 480 acatcactgg cgccctgcag atttacacag acatcatcta catcttcacc tttgtgctgc 540 agctgatggg ggatcgcaat taaggagcaa gcccccattt tcacccgatc ctgggctctc 600 ccttccaagc tagaggggct gggccctatg actgtgggtc tggggctttt aggccccttt 660 ccntccccct tgnggttaac atgncca 687 <210> 464 <211> 601 <212> DNA <213> Homo sapiens <400> 464 aaaaaactct ttcttcggct cgcgagctga gaggagcagg tagaggggca gaggcgggac 60 tgtcgtctgg gggagccgcc caggaggctc ctcaggccga ccccagtccc tggctggcca 120 ggatgaagta tctccggcac cggcggccca atgccaccct cattctggcc atcggcgctt 180 tcaccctcct cctcttcagt ctgctagtgt caccacccac ctgcaaggtc caggagcagc 240 caccggcgat ccccgaggcc ctggcctggc ccactccacc cacccgccca gccccggccc 300 cgtgccatgc caacacctct atggtcaccc acccgaactt cgccacgcag ccgcagcacg 360 ttcagaactt cctcctgtac agacactgcc gccactttcc cctgctgcag gacgtgcccc 420 cctctaagtg cgcgcagccg gtcttcctgc tgctggtgat caagtcctcc cctagcaact 480 atgtgcgccg cgagctgctg cggcgcacgt ggggccgcga gcgcaaggta cggggtttgc 540 agctgcgcct cctcttcctg gtgggcacag cctcnaaccc gcacgangcc cgcanggtca 600 a 601 <210> 465 <211> 609 <212> DNA <213> Homo sapiens <400> 465 aaaaaaaatt ccgccaagtc tctcgctctg cccaggacgc acagatgaga gcgctccgaa 60 gactgattca gggcaggatc ctgctcctga ccatctgcgc tgccggcatt ggtgggactt 120 ttcagtttgg ctataacctc tctatcatca atgccccgac cttgcacatt caggaattca 180 ccaatgagac atggcaggcg cgtactggag agccactgcc cgatcaccta gtcctgctta 240 tgtggtccct catcgtgtct ctgtatcccc tgggaggcct ctttggagca ctgcttgcag 300 gtcccttggc catcacgctg ggaaggaaga agtccctcct ggtgaataac atctttgtgg 360 tgtcagcagc aatcctgttt ggattcagcc gcaaagcagg ctcctttgag atgatcatgc 420 tgggaagact gctcgtggga gtcaatgcag gtgtgagcat gaacatccag cccatgtacc 480 tgggggagag cgcccctaag gagctccgag gagctgtggn catgagctca gncatcttta 540 cggctctggg gatcgtgatg ggacaagtgg tcggactcag ggagctccta ggtggccctc 600 aaggcctgn 609 <210> 466 <211> 726 <212> DNA <213> Homo sapiens <400> 466 actcgatcag cccgccggct ccggagcggc tctgccttcc cgagcgcggg acgcggcgcc 60 ctgggggagg agggcgaagc gacgcggcga tggctccgcg ggcactcccg gggtccgccg 120 tcctagccgc tgctgtcttc gtgggaggcg ccgtgagttc gccgctggtg gctccggaca 180 atgggagcag ccgcgcattg cactccagaa cagagacgac cccgtcgccc agcaacgata 240 ctgggaatgg acacccagaa tatattgcat acgcgcttgt ccctgtgttc tttatcatgg 300 gtctctttgg cgtcctcatt tgccacctgc ttaagaagaa aggctatcgt tgtacaacag 360 aagcagagca agatatcgaa gaggaaaagg ttgaaaagat agaattgaat gacagtgtga 420 atgaaaacag tgacactgtt gggcaaatcg tccactacat catgaaaaat gaagcgaaat 480 gctgatgtct taaaggcgat ggtagcagat aacagcctgt atgatcctga aagccccgtg 540 acccccagca caccagggag cccgccagtg agtcctgggc ctttgtcacc aggggggacg 600 ccagggaagc acgtctgtgg ccatcatctg catacggtgg gcggtgttgt caaaagggat 660 gtgtgtcatc cggtgtaagc acaancggtg gcactttata aagcccacta acangtccag 720 agagna 726 <210> 467 <211> 672 <212> DNA <213> Homo sapiens <400> 467 gaagtagccg caggcatggc ggcggctatg ccgcttgctc tgctcgtcct gttgctcctg 60 gggcccggcg gctggtgcct tgcagaaccc ccacgcgaca gcctgcggga ggaacttgtc 120 atcaccccgc tgccttccgg ggacgtagcc gccacattcc agttccgcac gcgctgggat 180 tcggagcttc agcgggaagg agtgtcccat tacaggctct ttcccaaagc cctggggcag 240 ctgatctcca agtattctct acgggagctg cacctgtcat tcacacaagg cttttggagg 300 acccgatact gggggccacc cttcctgcag gccccatcag gtgcagagct gtgggtctgg 360 ttccaagaca ctgtcactga tgtggataaa tcttggaagg agctcagtaa tgtcctctca 420 gggatcttct gcgcctctct caacttcatc gactccaaca acacagtcac tcccactgcc 480 tccttcaaac ccctgggtct ggccaantga cactgancac tactttctgc gctatgctgt 540 gctgccgcgg gaggtggtct gcaccgaaaa cctcaccccc tggnagaagc tcttgccctg 600 tagttccaag gcaggcctct ctgtgctgnt gaaggnaatc gcttgttcca cacagctaca 660 actcccaggg ag 672 <210> 468 <211> 720 <212> DNA <213> Homo sapiens <400> 468 agaaggagag acggctggcc accatgcacg gctcctgcag tttcctgatg cttctgctgc 60 cgctactgct actgctggtg gccaccacag gccccgttgg agccctcaca gatgaggaga 120 aacgtttgat ggtggagctg cacaacctct accgggccca ggtatccccg ccggcctcag 180 acatgctgca catgagatgg gacgaggagc tggccgcctt cgccaaggcc tacgcacggc 240 agtgcgtgtg gggccacaac aaggagcgcg ggcgccgcgg cgagaatctg ttcgccatca 300 cagacgaggg catggacgtg ccgctggcca tggaggagtg gcaccacgag cgtgagcact 360 acaacctcan cgccgccacc tgcagcccag gccagatgtg cggccactac acgcaggtgg 420 tatgggccaa gacaganagg atcggctgtg gttcccactt ctgtgagaag ctccagggtg 480 ttgaggagac caacatcgaa ttactggtgt gcaactatga gcctccgggg aacgtgnagg 540 ggaaacggcc ctaccagggg gggactccgt gctcccaatt gtccctctgg ctaccactgc 600 anagaactcc tctgtgaacc catctgaagc ccggaaagat gctcagggat ttgccttacc 660 tggtaaatga ggcccatctt ccgggcgact gangcatcag actcnangga aaatgggtac 720 <210> 469 <211> 663 <212> DNA <213> Homo sapiens <400> 469 tgcatgctga agctctaccg gaagcggcac ccggacatca acgccagcgc ctacagtgcc 60 tacgcctgcc tggccattgt catcttcttc tctgtgctgg gcgtggtctt tggcaaaggg 120 aacacggcgt tctggatcgt cttctccatc attcacatca tcgccaccct gctcctcagc 180 acgcagctct attacatggg ccggtggaaa ctggactcgg ggatcttccg ccgcatcctc 240 cacgtgctct acacagactg catccggcag tgcagcgggc cgctctacgt ggaccgcatg 300 gtgctgctgg tcatgggcaa cgtcatcaac tggtcgctgg ctgcctatgg gcttatcatg 360 cgccccaatg atttcgcttc ctacttgttg gccattggca tctgcaacct gctcctttac 420 ttcgccttct acatcatcat gaagctccgg agtggggaga ggatnaagct catccccctg 480 ctctgcatcg tttgcacctc cgtggtctgg ggcttcgcgc tcttcttctt cttccaggga 540 ctcaacacct ggcagaaaac ccctgcagag tcnanggagc acaaccggga ctgcatcctc 600 ctcgacttct ttaacgacca cgacatctgg gacttcctct cctccatcgc catgttcngg 660 tcc 663 <210> 470 <211> 697 <212> DNA <213> Homo sapiens <400> 470 aggtgtgtgc agggggtggg tgtgttagcg tgggttaggg gaacgtgtgt gcgcgtgctg 60 gtgggcatgt gagatgagtg actgccggtg aatgtgtcca cagttgagag gttggagcag 120 gatgagggaa tcctgtcacc atcaataatc acttgtggag cgccagctct gcccaaggcg 180 ccacctgggc ggacagccag gaactctcca tggccaggct gcctgtgtgc atgttccctg 240 tctggtgccc ctttgcccgc ctcctgcaaa cctcacaggg tccccacaca acagtgccct 300 ccagaagcag cccctcggag gcagaggaag gaaaatgggg atggctgggg ctctctccat 360 cctccttttc tccttgcctt cgcatggctg gccttcccct ccaaaacctc cattcccctg 420 ctgccagccc ctttgccata gcctgatttt ggggaggagg aaggggcgat ttgagggaga 480 aggggagaaa gcttatggct gggtctggtt tcttcccttc ccagagggtc ttactgttcc 540 agggtggccc caagggcagg caggggccac actatgcctg cgccctggta aaggtgaccc 600 ctgccattta ccaacagcct ggcatttcct gccccaaaag gaattgaatg gnggagctcc 660 anaaactttc catnccaaag gaatctccgt ggtttga 697 <210> 471 <211> 704 <212> DNA <213> Homo sapiens <400> 471 atactcctaa gctcctcccc cggcggcgag ccagggagaa aggatggccg gcctggcggc 60 gcggttggtc ctgctagctg gggcagcggc gctggcgagc ggctcccagg gcgaccgtga 120 gccggtgtac cgcgactgcg tactgcagtg cgaagagcag aattgctctg ggggcgctct 180 gaatcacttc cgctcccgcc agccaatcta catgagtcta gcaggctgga cctgtcggga 240 cgactgtaag tatgagtgta tgtgggtcac cgttgggctc tacctccagg aaggtcacaa 300 agtgcctcag ttccatggca aggtgtccct caatgcatgg ttctggccca cagttttcca 360 caccagggac actgacctca cagagaaaat ggactacttc tgtgcctcca ctgtcatcct 420 acactcaatc tacctgtgct gcgtcaggac cgtggggctg cagcacccag ctgtggtcag 480 tgccttccgg gctctcctgc tgctcatgct gaccgtgcac gtctcctacc tgagcctcat 540 ccgcttcgac tatggctaca acctggtggc caacgtggct attgggcctg gtcaacgtgg 600 tgtggtggct ggcctgggtg cctgtggnaa canccggcgg ctgcctcacg tgcgcaaagc 660 gcctggtggg tggtccntgc tgctgcaagg ggctgtccct gctc 704 <210> 472 <211> 659 <212> DNA <213> Homo sapiens <400> 472 aaaaagcggg tccgagccgc cgccgcgcgc gcgccgcgca ctgcagcccc aggccccggc 60 cccccaccca cgtctgcgtt gctgccccgc ctgggccagg ccccaaaggc aaggacaaag 120 cagctgtcag ggaacctccg ccggagtcga atttacgtgc agctgccggc aaccacaggt 180 accaagatgg tttgcggggg cttcgcgtgt tccaagaact gcctgtgcgc cctcaacctg 240 ctttacacct tggttagtct gctgctaatt ggaattgctg cgtggggcat tggcttcggg 300 ctgatttcca gtctccgagt ggtcggcgtg gtcattgcag tgggcatctt cttgttcctg 360 attgctttag tgggtctgat tggagctgta aaacatcatc aggtgttgct atttttttat 420 atgattattc tgttacttgt atttattgtt cagtcttctg tatcttgcgc ttgtttagcc 480 ctgaaccaag agcaacaggg tcagcttctg gaggttggtt ggaacaatac ggcaagtgct 540 cgaaatgaca tccagagaaa tctaaactgc tgtgggttcc gaagtgttaa cccaaatgac 600 acctgtctgg ctanctgtgt taaaagtgac cactcgtgct cncatgngct ccaatcata 659 <210> 473 <211> 700 <212> DNA <213> Homo sapiens <400> 473 aaaagcgctg gccggagggc ccgcggccgg gccgccgggg tgagcgtgtc gaggcggctg 60 tggcgcaggc ttccagcccc caccatgccg tggcccctgc tgctgctgct ggccgtgagt 120 ggggcccaga caacccggcc atgcttcccc gggtgccaat gcgaggtgga gaccttcggc 180 cttttcgaca gcttcagcct gactcgggtg gattgtagcg gcctgggccc ccacatcatg 240 ccggtgccca tccctctgga cacagcccac ttggacctgt cctccaaccg gctggagatg 300 gtgaatgagt cggtgttggc ggggccgggc tacacgacgt tggctggcct ggatctcagc 360 cacaacctgc tcaccagcat ctcacccact gccttctccc gccttcgcta cctggagtcg 420 cttgacctca gccacaatgg cctgacagcc ctgccagccg agagcttcac cagctcaccc 480 ctgagcgacg tgaaccttag ccacaaccaa gctccgggag gtctcantgt ctgccttcac 540 gacgcacagt cagggccggg cactacacgt ggacctctcc cacaacctca ttcaacgcct 600 cgtgccccaa cccacgaagg gccgggctgc ctgcgcccaa cattcagagc ctgaanctgg 660 gcctggaaac cggntncaat gccgttgcca aacctccgaa 700 <210> 474 <211> 698 <212> DNA <213> Homo sapiens <400> 474 atgcgcagcg gggccgtggg tgtacgcggc gcagcgcggc agtcctgatg gcccggcatg 60 ggttaccgct gctgcccctg ctgtcgctcc tggtcggcgc gtggctcaag ctaggaaatg 120 gacaggctac tagcatggtc caactgcagg gtgggagatt cctgatggga acaaattctc 180 cagacagcag agatggtgaa gggcctgtgc gggaggcgac agtgaaaccc tttgccatcg 240 acatatttcc tgtcaccaac aaagatttca gggattttgt cagggagaaa aagtatcgga 300 cagaagctga gatgtttgga tggagctttg tctttgagga ctttgtctct gatgagctga 360 gaaacaaagc cacccagcca atgaagtctg tactctggtg gcttccagtg gaaaaggcat 420 tttggaggca gcctgcangt cctggctctg gcatccgaga gagactggag cacccagtgt 480 tacacgtgag ctggaatgac gcccgtgcct actgtgcttg gcggggaaaa cgactgccca 540 cggaggaaga gtgggagttt gccgcccgag ggggcttgaa gggtcaagtt tacccatggg 600 ggaactggtt ccagcaaacc gcaccaacct gtggcaagga aagttcccaa ngggagacaa 660 agctgaggat ggcttcatgg atctccccan ttgnaaat 698 <210> 475 <211> 685 <212> DNA <213> Homo sapiens <400> 475 gaaaacggga tattcagcag tggcctgtgg ctgccagagc agctcctcag gggaaactaa 60 gcgtcgagtc agacggcacc ataatcgcct ttaaaagtgc ctccgccctg ccggccgcgt 120 atcccccggc tacctgggcc gccccgcggc ggtgcgcgcg tgagagggag cgcgcgggca 180 gccgagcgcc ggtgtgagcc agcgctgctg ccagtgtgag cggcggtgtg agcgcggtgg 240 gtgcggaggg gcgtgtgtgc cggcgcgcgc gccgtggggt gcaaaccccg agcgtctacg 300 ctgccatgag gggcgcgaac gcctgggcgc cactctgcct gctgctggct gccgccaccc 360 agctctcgcg gcagcagtcc ccaaagagac ctgttttcac atgtggtggc attcttactg 420 gagagtctgg atttattggc agtgaangtt ttcctggagt gtaccctcca aatagcaaat 480 gtacttggaa aatcacagtt cccgaaggaa aagtagtcgt tctcaatttc cgattcatag 540 acctcgagag tgacaacctg tgccgctatg actttgtgga tgtgtacaat ggncatgcca 600 atggccagcg cattggccgc ttctgtggca ctttccggnc tggagcccnt gtgtcaagtg 660 gcaacaaaga tgatggtgca aatga 685 <210> 476 <211> 774 <212> DNA <213> Homo sapiens <400> 476 gcacgttcct tctactctgg caccactctc caggctgcca tggggcccag cacccctctc 60 ctcatcttgt tccttttgtc atggtcggga cccctccaag gacagcagca ccaccttgtg 120 gagtacatgg aacgccgact agctgcttta gaggaacggc tggcccagtg ccaggaccag 180 agtagtcggc atgctgctga gctgcgggac ttcaagaaca agatgctgcc actgctggag 240 gtggcagaga aggagcggga ggcactcaga actgaggccg acaccatctc cgggagagtg 300 gatcgtctgg agcgggaggt anactatctg gagacccaga acccagctct gccctgtgta 360 gagtttgatg agaaggtgac tggaggccct gggaccaaag gcaagggaag aaggaatgag 420 aagtacgata tggtgacaga ctgtggctac acaatctctc aagtgagatc aatgaagatt 480 ctgaagcgat ttggtggccc agctggtcta tggaccaagg atccactggg gcaaacagaa 540 aanatctacg tgttanatgg gacacagaat gacacagcct ttgtcttccc aagggtgcgt 600 gacttcccct tgccatggct tgccccggaa agcttcccga atccgggttg ccttccctgg 660 gttaggcaca gggcactggt atatggtggc tttctttatt tttgctcnga ngctcctgna 720 aaaactggtt ggaagtggtg aaatngaaaa cactttgcag cttantccaa ttcc 774 <210> 477 <211> 671 <212> DNA <213> Homo sapiens <400> 477 aggattcttc tcatcgcagt gctccaggca gccactacca atcgattgga gttagcctgt 60 gaggaaactg gagaggcgtg gctggaccaa gacctccccc catgtgagca ggcttcctcc 120 tcccccaaca accgttgcca ccacgcccag aaacgtcctt aagccctggc cctcagggga 180 aaggtagcag gaggccagag ccgggaccat gtgacggcgc tggccctcgc caccgccgtc 240 ccccgaccct ggccccaggc ccggcaccat gatgttccga gaccaggtgg gcatcctcgc 300 tggctggttc aaaggctgga atgagtgtga gcagacagtg gccctcctgt cacttctgaa 360 acgggtcatc cgtacccagg cccgcttcct gcagctctgc ctggagcact cactggcgga 420 ctgcaatgac atccacctgc tggagtcgga ggccaacagt gctgccatcg tcagccagtg 480 gcagcaggag tccaaagaga aggtggtgtc cctcctgctg tcccaccttc ccctgcttca 540 gccaggcaac acagangcca agtcggagta catgaggcta ctgcagaaag tgctggncta 600 ctcaatcgag agcaatgctt tcatcnatgg agagtcgcca actgctttcc taatgccctc 660 atccanccaa g 671 <210> 478 <211> 591 <212> DNA <213> Homo sapiens <400> 478 ccttcagtct cagccgccaa ctccggaggc gcggtgctcg gcccgggagc gcgagcggga 60 ggagcagaga cccgcagccg ggagcccgag cgcgggcgat gcaggctccg cgagcggcac 120 ctgcggctcc tctaagctac gaccgtcgtc tccgcggcag cagcgcgggc cccagcagcc 180 tcggcagcca cagccgctgc agccggggca gcctccgctg ctgtcgcctc ctctgatgcg 240 cttgccctct cccggccccg ggactccggg agaatgtggg tcctaggcat cgcggcaact 300 ttttgcggat tgttcttgct tccaggcttt gcgctgcaaa tccagtgcta ccagtgtgaa 360 gaattccagc tgaacaacga ctgctcctcc cccgagttca ttgtgaattg cacggtgaac 420 gttcaagaca tgtgtcagaa agaagtgatg gagcaaagtg ccgggatcat gtaccgcaag 480 tcctgtgcat catcagcggc ctgtctcatc gcctctgccg ggtaccagtc cttctgctcc 540 ccanggaaac tgaactcagt ttgcatcagc tgctgcaacc aaaaaccnnc c 591 <210> 479 <211> 639 <212> DNA <213> Homo sapiens <400> 479 tatgcctggg cagggcgaag ccagaggaaa ctctggtgga ggtccgtagc ggtcctgacg 60 tgcaaatcgg tcgtccgacc tgggtatagg ggcgaaagac taatcgaacc atctagtagc 120 tggttccctc cgaagtttcc ctcaggatag ctggcgctct cgccgccgga ggaagatgag 180 gctgaagatt ggattcatct tacgcagttt gctggtggtg ggaagcttcc tggggctagt 240 ggtcctctgg tcttccctga ccccgcggcc ggacgaccca agcccgctga gcaggatgag 300 ggaagacaga gatgtcaatg accccatgcc caaccgaggc ggcaatggac tagctcctgg 360 ggaggacaga ttcaaacctg tggtaccatg gcctcatgtt gaaggagtag aagtggactt 420 agagtctatt agaagaataa acaaggccaa aaatgaacaa gagcaccatg ctggaggaga 480 ttcccagaaa gatatcatgc anangcagta tctcacattt aagcctcaga cattcaccta 540 ccatgatcct gtgcttcgcc cagggatcct cggtaacttt gaacccaaag aacctgagcc 600 tnctggagtg gttggtggcc ctgganagaa anccaagcc 639 <210> 480 <211> 550 <212> DNA <213> Homo sapiens <400> 480 ttggagcaag cggcggcggc ggagacagag gcagaggcag aagctggggc tccgtcctcg 60 cctcccacga gcgatccccg aggagagccg cggccctcgg cgaggcgaag aggccgacga 120 ggaagacccg ggtggctgcg cccctgcctc gcttcccagg cgccggcggc tgcagccttg 180 cccctcttgc tcgccttgaa aatggaaaag atgctcgcag gctgctttct gctgatcctc 240 ggacagatcg tcctcctccc tgccgaggcc agggagcggt cacgtgggag gtccatctct 300 aggggcagac acgctcggac ccacccgcag acggcccttc tggagagttc ctgtgagaac 360 aagcgggcag acctggtttt catcattgac agctctcgca gtgtcaacac ccatgactat 420 gcaaaggtca aggagttcat cgtggacatc ttgcaattct tggacattgg tcctgatgtc 480 acccgagtgg gcctgctcca atatggcanc actgtcaaga atganttctc cctcaagacc 540 ttaanaggaa 550 <210> 481 <211> 773 <212> DNA <213> Homo sapiens <400> 481 tgttttgttt ctttatttgg gacttaacgg ccactcattt ctgttggcgc catgcgactg 60 ttgccgtgtg cagcagggac ctctgccttc ctctcctccc agctcacaat aggtgcctct 120 tcctcctccc ggccatccac gccggcctgg ttttcggttc tggaatacat ccaacccttt 180 cgttcgtgtt cttttctcct gtcatcttct ccgcctggag ctcttccatg ttctctttgc 240 acaagcgact ctatccttcc agtttcagat gatttcacct cctcaaagag gcctttggga 300 ccagcctttt ctaaagcttt ccttgagaat gctggtcaag atttaccttt taattttgtt 360 ttttctgttt gttctgtctc ctctgccggc tgcttgagct ccaggatcac agaggacatg 420 agtgttctgt tcccactgat gcctggtgcc agactgggac acgtgtgctc agccatggct 480 aatgtgcgca ggcagggatg gtcacacagt ggcctcttgg cgctctggcc gagtgggagg 540 agcangggga ggagctgtca gaaggagacc tgcctagtca caggcaggtc acagggcttc 600 cagaatccca ttcangtgat cccctcctgn tgggtaaaac aagcacacct canaagtggt 660 gttttgtcat aagttgttct taatggctcc caaaagcctc aatctccggt tttgtccaat 720 ttggggattg aagggaagtt tgnttgaagt ccaangcggt caacctttca nga 773 <210> 482 <211> 747 <212> DNA <213> Homo sapiens <400> 482 acagccgacg aggcaacaat taggctttgg ggataaaacg aggtgcggag agcgggctgg 60 ggcatttctc cccgagatgg cgggtctgac ggcggcggcc ccgcggcccg gagtcctcct 120 gctcctgctg tccatcctcc acccctctcg gcctggaggg gtccctgggg ccattcctgg 180 tggagttcct ggaggagtct tttatccagg ggctggtctc ggagcccttg gaggaggagc 240 gctggggcct ggaggcaaac ctcttaagcc agttcccgga gggcttgcgg gtgctggcct 300 tggggcaggg ctcggggctc tcggtggagt aggcatccca ggcggtgtgg tgggagccgg 360 acccgccgcc gccgctgccg cagccgctaa ggcagccaag tatggagctg ctgcaggctt 420 agtgcctggt gggccaggct ttggcccggg agtagttggt gtcccaggag ctggcgttcc 480 aggtgttggt gtcccaggag ctgggattcc agttgtccca ggtgctggga tcccaggtgc 540 tgcggttcca ggggttgtgt caccagaagc agctgctaag gcagctgcaa aggcagccaa 600 atacggggcc aggcccggaa gtcggaattt ggaggcattc ctacttacgg ggtttggagc 660 ctggggggct tttccccggc tttggtgtcc ggagtccgga ggtatcccct tggaagtccc 720 aagggtgtcc ccttggntgn tccngaa 747 <210> 483 <211> 830 <212> DNA <213> Homo sapiens <400> 483 aactacacca gggccggtgc acctcggggc ggcggcgcag gactaggctc ggcctcccag 60 cgctcccaag ccgcagcggc cgcgcccctt cagctagctc gctcgctcgc tctgcttccc 120 tgctgccggc tgcgccatgg cgttggcgtt ggcggcgctg gcggcggtcg agccggcctg 180 cggcagccgg taccagcagt tgcagaatga agaagagtct ggagaacctg aacaggctgc 240 aggtgatgct cctccacctt acagcagcat ttctgcagag agcgcagcat attttgacta 300 caaggatgag tctgggtttc caaagccccc atcttacaat gtagctacaa cactgcccag 360 ttgtttttat gatatcagcc atttgatttt tttcattttc tatttaagaa atatgaagaa 420 aaaatacacc aagatggtca aattactaca caaatcagca ccagcacagt ctgatagctg 480 caaatgtcca ttcatctgct gtgtatgtat atccagaatc agcataggaa gtcgttcagg 540 atatcagtat ataatgcaca gaagtgtggg ttgtttgaaa gccaaacagg aaaattagga 600 gcctcctgga ttgacatttc aagtgatcct ctaaccagtt tatggattan tatgaataat 660 aatgtagtat gttctttttc anaagttata tttgataata gagaagggag ttttatggga 720 aagtttcttt gaangatttt tttttttcca tttcgaatca agatttatag caacaattgg 780 gggtttggna attttggtat ggggcctaan aaaggttcct aaagtttcca 830 <210> 484 <211> 855 <212> DNA <213> Homo sapiens <400> 484 atcaaacagt gagctgatcc gcctgatcaa caacgccatc aagaatgacc tggccagccg 60 caaccccacc ttcatgggcc tggccctgca ctgcatcgcc agcgtgggca gccgggagat 120 ggccgaggcc ttcgccgggg agatccctaa ggtcctcgta gccggagaca ctatggacag 180 cgtgaagcag agcgcggccc tgtgcttgct gcgcctgtac aggacgtccc ccgatcttgt 240 ccccatgggc gactggacat cccgagtggt gcacctgctc aatgaccagc acttgggtgt 300 ggtaactgca gccacaagtc tgatcaccac tttagcacag aagaacccag aagagtttaa 360 aacctccgtg tctctggctg tctctaggct aagcagaatc gtgacgtctg catccacaga 420 tctccaggat tacacttact attttgtccc ggctccctgg ctgtctgtca aactgctgag 480 actgctgcag tgctacccac ccccagaccc tgcagtgcga ggccgcctga ctgagtgcct 540 ggagaccatc ctgaacaaag cccaagaacc gcccaagtcg aagaaggtcc agtactccaa 600 cgcgaagaat gccgtgcttt tcgaggccat cagcttaatc attcaccatg acagtgagcc 660 gaacctgctc gtccgtgcct gcaaccagtt gggccagttt ctgcagcacc gcgagaccaa 720 ctgcgctacc tggcctggag agcatgtgca cgctgccagc tctgagttct ccatgaggct 780 gtcaagacca cattgagacg gcatnaacgc cctgaaactg aaccggacct gaacgtnctt 840 gccgnccaac cgctt 855 <210> 485 <211> 663 <212> DNA <213> Homo sapiens <400> 485 gaccccggcg cgcgcgcggc ggaggacgag gaagagttgt ggcgaggcag atcctgcccc 60 gtggccgcgg ccgtctcgtg tcccaccggc cttccgggtt ccagcgccag gcctggtgcc 120 tgccccagga ggatgagcat ttgcattgcc tgcaccttat cgtgcccttc cacctgctga 180 agcagctgtg cctgccgctc ttgtgaactg cgaacttccc cttacctcct ctctctggct 240 cgggagctgg ctcggccgcc tgtcagtgca atgctgcccc atgtggtgct caccttccgg 300 cgcctgggct gcgccttggc gtcctgccgg ctggcgcctg cgagacacag aggaagtggt 360 cttctgcaca cagccccagt ggcccgctcg gacaggagcg ccccggtgtt cacccgtgcc 420 ctggcctttg gggacagaat cgccctggtt gaccagcacg gncgcacacg tacagggagc 480 tttattcccg cagccttcgc ctgtcccagg agatctgcag gctctgcggg tgtgtcggcg 540 gggacctccg ggaggagagg gtctccttcc tatgcgctaa cgatgccttc tacgtcgtgg 600 cccantgggc gtcatggatg antggcggtg tggcagtccc cctntacagg aagcattccg 660 cgg 663 <210> 486 <211> 736 <212> DNA <213> Homo sapiens <400> 486 atttcctttc tccacatcca ggtcaggtgg cgtttgctgt ggcggctagg cccgcgtgcg 60 ctggagacct ccgcgctggc ccccgcgagc ctcctgccct ggcccggcgc tgcggctctg 120 ccgcggcggc agcatgggtg gcccccgggg cgcgggctgg gtggcggcgg gcctgctgct 180 cggcgcgggc gcctgctact gcatttacag gctgacccgg ggtcggcggc ggggcgaccg 240 cgagctcggg atacgctctt cgaagtccgc aggtgccctg gaagaaggga cgtcagaggg 300 tcagttgtgc gggcgctcgg cccggcctca gacgggaggt acctgggagt cacagtggtc 360 caagacctcg cagcctgaag acttgactga tggttcatat gatgatgttc taaatgctga 420 acaacttcag aaactccttt acctgctgga gtcaacggag gatcctgtaa ttattgaaag 480 agctttgatt actttgggta acaatgcagc cttttcagtt aaccaagcta ttattcgtga 540 attgggtggt attccaattg ttgcaaacaa aatcaaccat tccaaccaga gtattaaaga 600 gaaagcttta aatgcactaa ataacctgag tgtgaatgtt gaaaatcaaa tcaagatnaa 660 gatatacatc agtcaagtat gtgangatgc ttctctggcc tctgaactct gctgtgcact 720 ggntggactg acattg 736 <210> 487 <211> 665 <212> DNA <213> Homo sapiens <400> 487 attcggcggg agcacccagt cctgtacgcc aaggaactgg tcctgggggc accatggttt 60 cggcggcagc ccccagcctc ctcatccttc tgttgctgct cctggggtct gtgcctgcta 120 ccgacgcccg ctctgtgccc ctgaaggcca cgttcctgga ggatgtggcg ggtagtgggg 180 aagccgaggg ctcgtcggcc tcctccccga gcctcccgcc accctggacc ccggccctca 240 gccccacatc gatggggccc cagcccacaa ccctgggggg cccatcaccc cccaccaact 300 tcctggatgg gatagtggac ttcttccgcc agtacgtgat gctgattgct gtggtgggct 360 ccctggcctt tctgctgatg ttcatcgtct gtgccgcggt catcacccgg cagaagcaga 420 aggcctcggc ctattaccca tcgtccttcc ccaagaagaa gtacgtggac cagagtgacc 480 gggccggggg cccccgggcc ttcagtgagg tccccgacag agcccccgac agcaggcccg 540 aggaagccct ggattcctcc cggcagctcc aggccgacat cttggccgca cccagaacct 600 naagtccccc accanggctg cactgggcgg tggggacgga nccaggatgg tggaaggcaa 660 ggggc 665 <210> 488 <211> 905 <212> DNA <213> Homo sapiens <400> 488 tctgaggcag gtgcccgaca tggcgagtgt agtgctgccg agcggatccc agtgtgcggc 60 ggcagcggcg gcggcggcgc ctcccgggct ccggctccgg cttctgctgt tgctcttctc 120 cgccgcggca ctgatcccca caggtgatgg gcagaatctg tttacgaaag acgtgacagt 180 gatcgaggga gaggttgcga ccatcagttg ccaagtcaat aagagtgacg actctgtgat 240 tcagctactg aatcccaaca ggcagaccat ttatttcagg gacttcaggc ctttgaagga 300 cagcaggttt cagttgctga atttttctag cagtgaactc aaagtatcat tgacaaacgt 360 ctcaatttct gatgaaggaa gatacttttg ccagctctat accgatcccc cacaggaaag 420 ttacaccacc atcacagtcc tggtcccacc acgtaatctg atgatcgata tccagaaaga 480 cactgcggtg gaaggtgagg agattgaagt caactgcact gctatggcca gcaagccagc 540 cacgactatc aggtggttca aagggaacac agagctaaaa ggcaaatcgg aggtggaaga 600 gtggtcagac atgtacactg tgaccagtca gctgatgctg aaggtgcaca aggaggacga 660 tggggtccca gtgatctgcc aggtggagca ccctgcggtc actggaaacc tgcagaccca 720 gcggtatcta gaagtcagta taagcctnaa gtgcccattc agatgactta tcctctacaa 780 ggcttaaccc cgggaagggg accgcttgag ttaacatggt gaagccattg ggaagcccca 840 accctgtgat ggtaacttgg gtgaaagtcg atgatgaaat gccttaacaa cgcccgtact 900 gtntg 905 <210> 489 <211> 808 <212> DNA <213> Homo sapiens <400> 489 agaggggaac aagatggcgg cgccgaaggg gagcctctgg gtgaggaccc aactggggct 60 cccgccgctg ctgctgctga ccatggcctt ggccggaggt tcggggaccg cttcggctga 120 agcatttgac tcggtcttgg gtgatacggc gtcttgccac cgggcctgtc agttgaccta 180 ccccttgcac acctacccta aggaagagga gttgtacgca tgtcagagag gttgcaggct 240 gttttcaatt tgtcagtttg tggatgatgg aattgactta aatcgaacta aattggaatg 300 tgaatctgca tgtacagaag catattccca atctgatgag caatatgctt gccatcttgg 360 ttgccagaat cagctgccat tcgctgaact gagacaagaa caacttatgt ccctgatgcc 420 aaaaatgcac ctactctttc ctctaactct ggtgaggtca ttctggagtg acatgatgga 480 ctccgcacag agcttcataa cctcttcatg gactttttat cttcaagccg atgacggaaa 540 aatagttata ttccagtcta agccagaaat ccagtacgca ccacatttgg agcaggagcc 600 tacaaatttg agagaatcat ctctaagcaa aatgtcctat ctgcaaatga gaaattcaca 660 agcgcacagg aattttcttg aagatggaga aagtgatggc ttttttaaga tgcctctctt 720 ttaactctgg gtggaattta actacaactn ttgncctctc ggggaggaat tgctttggat 780 ttgtngccac tgtgctacac tgggaaca 808 <210> 490 <211> 861 <212> DNA <213> Homo sapiens <400> 490 atcaagtcag agttcgtggt ggcttaggat cttcggatcg gccaccctcg cccctcgcac 60 cccagcccag ggcggcgggg actccgagag ccccggagag aacgtggccc agccctggag 120 ggcaggcggc cactccccca gccagaagtc tttttttctt ttcttctttt ttattatttt 180 tttctttttt taaaaagttc tgaccgtggt ttcctggact cttcatgggc tttgcttcct 240 acctccttca cccttcactc ctgccctcct cttcctcctc ctcctcctcc tctgtctgtc 300 tcctttcacc tctgcgccag gtcggtcctc cctgccaacc ttccccagct ccaatatgta 360 gcagtctctc tggatggcgg agagtgaagg agacggagaa acgcgcccca tcccttccgc 420 cgcctccttt cccccccgac cctattcagg ttttaagtca aaaatgtcga tatgtcatta 480 tgcactttac agatgagggg aggggccgca gtgcgcagaa cccaccccac cccccagtgc 540 agacttcggg gtctccaccc caggccagca gcgcccactg ggctacagca agccaacagg 600 tcacagaagc caacgagggg actgtttctc ttccactcct atcctcttct tgatcttttt 660 ttttgcattt tccttcattt ctttaacaag gagagcaaaa gctggtttag cagaagctgg 720 ggctgangtc cccatggggt ttgggtgcaa ggggcatggc acccttttct ggccggaaag 780 gganaagggg aaactacccc cccaagcctg gccttcggcc cggccccaaa ccggnggact 840 gngctggttc ctccgccccc a 861 <210> 491 <211> 846 <212> DNA <213> Homo sapiens <400> 491 tgggcgcgcg cccgccccag ttatcatggc ggctcccttg gtcctggtgc tggtggtggc 60 tgtgacagtg cgggcggcct tgttccgctc cagtctggcc gagttcattt ccgagcgggt 120 ggaggtggtg tccccactga gctcttggaa gagagtggtt gaaggccttt cactgttgga 180 cttgggagta tctccgtatt ctggagcagt atttcatgaa actccattaa taatatacct 240 ctttcatttc ctaattgact atgctgaatt ggtgtttatg ataactgatg cactcactgc 300 tattgccctg tattttgcaa tccaggactt caataaagtt gtgtttaaaa agcagaaact 360 cctcctagaa ctggaccagt atgccccaga tgtggccgaa ctcatccgga cccctatgga 420 aatgcgttac atccctttga aagtggccct gttctatctc ttaaatcctt acacgatttt 480 gtcttgtgtt gccaagtcta cctgtgccat caacaacacc ctcattgctt tcttcatttt 540 gactacgata aaaggcagtg ctttcctcag tgctattttt cttgccttag cgacatacca 600 gtctctgtac ccactcacct tgtttgtccc aggactcctc tatctcctcc agcggcagta 660 catacctgtg aaaatgaaga gcaaagcctt ctggatcttt tcttgggagt atgccatgat 720 gtatgtggga aacctaatgg taatcatttg cctctccttc ttncttctca gctcttggga 780 tttcatcccg nagctatggc tttatacttt ctggtccaga tctcacttca aacattggnc 840 ttttct 846 <210> 492 <211> 835 <212> DNA <213> Homo sapiens <400> 492 gagaccgacc cgccacccgc cgtagcccgc gcgcccctgg cactcaatcc ccgccatgtg 60 ggggctcctg ctcgccctgg ccgccttcgc gccggccgtc ggccctgccc agtctcagac 120 cccaatgacc tattccttga ggcccctgcg tcgggatcct ctgaccctct agactttcag 180 catcacaatt acaaggccat gaggaagctg atgaagcagg tacaagagca atgccccaac 240 atcacccgca tctacagcat tgggaagagc taccagggcc tgaagctgta tgtgatggaa 300 atgtcggaca agcctgggga gcatgagctg ggggagcctg aggtgcgcta cgtggctggc 360 atgcatggga acgaggccct ggggcgggag ttgcttctgc tcctgatgca gttcctgtgc 420 catgagttcc tgcgagggaa cccacgggtg acccggctgc tctctgagat gcgcattcac 480 ctgctgccct ccatgaaccc tgatggctat gagatcgcct accaccgggg ttcagagctg 540 gtgggctggg ccgagggccg ctggaacaac cagagcatcg atcttaacca taattttgct 600 gacctcaaca caccactgtg ggaagcacag gacgatggga aggtgcccca catcgtgccc 660 aaccatcacc tgccattgcc cacttactac accctgccaa tgccaccgtg gcttctgaaa 720 cgcggcagta atcaagtgga tgaacngatc cctttgngct aagtgccaac cttcacgggg 780 gtgagctcgt ggngtcctac ccattcgaca tgacttggac ccctgggctt cccgc 835 <210> 493 <211> 455 <212> DNA <213> Homo sapiens <400> 493 aaatttgcca ttcttagcaa ctggccagtc aacaactcaa ctttataatg ggaaaactag 60 acgagctgag attcaaccca cgtgagcggc tgcagagccg ctacccttaa cagctctctc 120 tcgggattct aacattccct tctgtgacgg agagacagca ggccgggaca cgcatcccag 180 gacggatcca cagctggatg gggaaggctg cgccaggcgg gccggaagcc tggcggtggc 240 gtgcaggagc cccgccctcc tgggctggat tcagccgggg gcggggccgc gggcggggcc 300 tgtggcagcg ggaatcccga ccncgcccct ttcctcaccc ctccatttct cgccatggcc 360 cctgcactgc tcctgatccc tgctgccctc gcccctttca tcctggcctt tgncaccgga 420 gtgnagttcg ngcgctttac ctcccttcgg ccact 455 <210> 494 <211> 905 <212> DNA <213> Homo sapiens <400> 494 aggaagagca gcggcgaggc ggcggtggtg gctgagtccg tggtggcaga ggcgaaggcg 60 acagctctag gggttggcac cggccccgag aggaggatgc gggtccggat agggctgacg 120 ctgctgctgt gtgcggtgct gctgagcttg gcctcggcgt cctcggatga agaaggcagc 180 caggatgaat ccttagattc caagactact ttgacatcag atgagtcagt aaaggaccat 240 actactgcag gcagagtagt tgctggtcaa atatttcttg attcagaaga atctgaatta 300 gaatcctcta ttcaagaaga ggaagacagc ctcaagagcc aagaggggga aagtgtcaca 360 gaagatatca gctttctaga gtctccaaat ccagaaaaca aggactatga agagccaaag 420 aaagtacgga aaccagcttt gaccgccatt gaaggcacag cacatgggga gccctgccac 480 ttcccttttc ttttcctaga taaggagtat gatgaatgta catcagatgg gagggaagat 540 ggcagactgt ggtgtgctac aacctatgac tacaaagcag atgaaaagtg gggcttttgt 600 gaaactgaag aagaggctgc taagagacgg cagatgcagg aagcagaaat gatgtaacaa 660 actggaatga aaatccttaa tggaagcaat aagaaaagcc naaaaagaga agcatatcgg 720 tatcttccaa aaggcagcaa gccatgaacc atcccaaaag cccctggaaa agaagtggtc 780 attatgcctc tttttaattt nggtggaatt accttgccca caggaattat tccaggccag 840 ccgaagaaga agatgntttg gaaaaaagct tgacttgaag gaaanggctt tttccccaag 900 gggan 905 <210> 495 <211> 841 <212> DNA <213> Homo sapiens <400> 495 cattctgagt atccttgaag tcattatcat cttgctgctc atctttctcc ggaagagaat 60 tctcatcgcg attgcactca tcaaagaagc cagcagggct gtgggatacg tcatgtgctc 120 cttgctctac ccactggtca ccttcttctt gctgtgcctc tgcatcgcct actgggccag 180 cactgctgtc ttcctgtcca cttccaacga agcggtctat aagatctttg atgacagccc 240 ctgcccattt actgcgaaaa cctgcaaccc agagaccttc ccctcctcca atgagtcccg 300 ccaatgcccc aatgcccgtt gccagttcgc cttctacggt ggtgagtcgg gctaccaccg 360 ggccctgctg ggcctgcaga tcttcaatgc cttcatgttc ttctggttgg ccaacttcgt 420 gctggcgctg ggccaggtca cgctggccgg ggcctttgcc tcctactact gggccctgcg 480 caagccggac gacctgccgg ccttcccgct cttctctgcc tttggccggg cgctcaggta 540 ccacacaggc tccctggcct ttggcgcgct catcctggcc attgtgcaga tcatccgtgt 600 gatactcgag tacctggatc agcggctgaa agctgcagag aacaagtttg ccaagtgcct 660 catgacctgt ctcaaatgct gcttctggtg cctggagaag ttcatcaaat tccttaatag 720 gaatgcctac atcatgattg ccatctacgn accaatttct gacctcggca ggaatgcttc 780 ttctgctatg agaaacatca tagaatggct gnctggataa gtactgattc ctttctgtgg 840 c 841 <210> 496 <211> 599 <212> DNA <213> Homo sapiens <400> 496 aggctgtgga gagagcgcgg agacaagcgc agagcgcagc gcacggccac agacagccct 60 gggcatccac cgacggcgca gccggagcca gcagagccgg aaggcgcgcc ccgggcagag 120 aaagccgagc agagctgggt ggcgtctccg ggccgccgct ccgacgggcc agcgccctcc 180 ccatgtccct gctcccacgc cgcgcccctc cggtcagcat gaggctcctg gcggccgcgc 240 tgctcctgct gctgctggcg ctgtacaccg cgcgtgtgga cgggtccaaa tgcaagtgct 300 cccggaaggg acccaagatc cgctacagcg acgtgaagaa gctggaaatg aagccaaagt 360 acccgcactg cgaggagaag atggttatca tcaccaccaa gagcgtgtcc aggtaccgag 420 gtcaggagca ctgcctgcac cccaagctgc agagcaccaa gcgcttcatc aagtggtaca 480 acgcctggaa cgagaagcgc agggtctacg aagaataggg tgaaaaacct cagaagggaa 540 aactccaaac cagttgggag acttgtgcaa aggactttgc agattaaaaa aaaaaannn 599 <210> 497 <211> 869 <212> DNA <213> Homo sapiens <400> 497 ctcgcagcca tggcggccgc cgcgctccca gcatggctgt ctctgcagtc gagggcaagg 60 actctgcgtg cattctccac tgccgtctac tcggccactc cggtcccgac acctagcctg 120 ccggaaagaa cacccggaaa tgaaaggcca ccaagaagaa aggcactacc tcctaggaca 180 gagaaaatgg ctgttgacca ggactggcct agtgtttacc cagttgcagc accatttaaa 240 ccctctgcag tacctcttcc tgttcgaatg ggttatccag taaaaaaggg cgtgcccatg 300 gcaaaggagg gaaatctaga acttttaaag attcccaatt ttctgcattt gactcctgta 360 gcaattaaaa agcactgtga agcccttaaa gatttttgca ctgagtggcc agccgcactg 420 gacagtgacg agaaatgtga gaagcatttt ccaattgaaa ttgacagcac tgattatgtt 480 tcatcaggac catctgttcg gaaccccaga gcacgagtag tagtcttaag agtaaagctt 540 tccagtttga atttagatga tcacgcaaag aagaaattaa ttaaacttgt aggagagcga 600 tactgcaaga ccacagatgt gcttaccatc aaaacagata ggtgcccttt aaggaggcag 660 aattacgatt atgcagtgta tctactaaca gtgttatacc atgagtcttg gaatactgaa 720 gaatgggaaa aagtaagact gaagcagaca tggaagagta tatatgggaa aatagcttca 780 tcagaaagaa atatnctgga aacgcttntc cagatgaaag cttgttgaga aaaaatatgg 840 gaaataaatt aaggaanaac ttccttggg 869 <210> 498 <211> 779 <212> DNA <213> Homo sapiens <400> 498 gcacttcagc ttcccctccc ccggcgccct ctggggctcc gagcccggcg ggaccatgtt 60 caccagcacc ggctccagtg ggctctacaa ggcgcctctg tcgaagagcc ttctgctggt 120 ccccagtgcc ctctccctcc tgctcgccct cctcctgcct cactgccaga agctctttgt 180 gtatgacctt cacgcagtca agaacgactt ccagcctggc acctgtgttt gctctgtttg 240 taccatttta ctgctccata ccaagagtcc aagtggcaca aattctgggt ccgttgtcca 300 tcacaaacaa gacattgatt tatatattgg gactgcagct tttcacctct ggttcctaca 360 tctggattgt agccataagt ggacttatgt ccggtctgtg ctacgacagc aaaatgttcc 420 aggtgcatca ggtgctctgc atccccagct ggatggcaaa attcttttct tggacacttg 480 aacccatctt ctcttcttca gaacccacca gcgaagccag aattgggatg ggagccacgc 540 tggacatcca gagacagcag agaatggagc tgctggaccg gcagctgatg ttctctcagt 600 ttgcacaagg gaggcgacag agacagcagc agggaggaat gatcaattgg aatcgtcttt 660 ttcctccttt acgtcagcga caaaacgtaa actatcaagg cggtcggcag tctgagccag 720 cagcgcccct ttagaagttt ctgaggaaca ngtcgcccgg ctcatggana anggatttt 779 <210> 499 <211> 748 <212> DNA <213> Homo sapiens <400> 499 ggcaaagccc tgtcaccccc aggatccggt catcagggaa agaggacagg gagaccagaa 60 gagggccagc tgggacgagg gggcggacgc ccaggaggca acttctgaga cgcagctcct 120 gagaggggca gggaccaggc gcgggaggcc agagggggca cagagaacaa accccctcag 180 aagtgaagag gagagcggaa ggaaccgaga ggggacggac aggagctgag gaggaaagag 240 gaggggagag gggtcaggcc aggcagccaa ggagaagacg tgtggccggg ggctatcaga 300 aggaaactgg gacggacggg ccgggctcgg gctgtcctgt ggagcagcag catccccggg 360 gccggcagag gcgccagtgg ctgggcggga tgagtctctg agggccactg tggagcgccc 420 cgccatggcc ccccgcaccc tctggagctg ctacctctgc tgcctgctga cggcagctgc 480 aggggccgcc agctaccctc ctcgaggttt cagcctctac acaggttcca gtggggccct 540 cagccccggg gggccccagg cccagattgc cccccggcca gccagccgcc acaggaactg 600 gtgtgcctac gtggtgaccc ggacagtgag ctgtgtcctt gaggatggag tggagacata 660 tgtcaagtac cagccttgtg cctggggcca gccccagtgt ncccaaagca tcatgtaccc 720 gccgntttct tccgcctngg taccgtgt 748 <210> 500 <211> 727 <212> DNA <213> Homo sapiens <400> 500 aaattggagg tcccgggagc gaagtccagc tgccgttagg cgctgggata gtcgcacgct 60 ggatgcatct acgtccgccg agcccctggg gcgaagaggc cgcgtccgcc ttcagttgtg 120 gccggtgctt cgccccctga cccttcgccc ccaaagacca gctctaacgt gagcgcctcg 180 gccgccctgc cccagcctcg tacacgccgc cagcctcgcc cagccggtgt ccggagaccc 240 tcgggccgtg tccatttgtg ggcaaagcca gcggggcagg cttggccaga gtgcaccact 300 cggcgccgtc ccaggcccga cgctctgggc gcgcccggaa ccccaggttc gcggcccgtg 360 tttccgaccg gcggaggggg ctcagcggcc cgatcccacg gaagcgcgct cggaggggtg 420 ggacccggcc ggaccggaga tggcgccgcc agcgggcggg gcggcggcgg cggcctcgga 480 cttgggctcc gccgcagtgc tcttggctgt gcacgccgcg gtgaggccgc tgggcgccgg 540 gccagacgcc gaggcacagc tgcggaggct gcagctgagc gcggaccctg agaggcctgg 600 gcgcttccgg cttggagctt gctgggcgcg ggacctgggg gcgggtaatt tggagtnggc 660 ccctggagtc agtttcctta caccattccg anggcccacc cagcacgagc tacagncttc 720 aaccaag 727 <210> 501 <211> 752 <212> DNA <213> Homo sapiens <400> 501 aacgagctcg ggcctcaccc ggatggcggc tgcgacgcgc ggctgccggc cctggggctc 60 gctcctcggg ctgctcgggc tggtctcggc cgcggccgcc gcctgggacc tggcttccct 120 gcgctgcacc ttgggcgcct tttgcgaatg cgacttccgg cccgacttgc cgggtctgga 180 gtgtgacctg gctcagcacc tggccggcca gcatctggcc aaggcgctgg tggtgaaggc 240 gctgaaggcc tttgtgcggg acccagcccc caccaagccg ctggtcctct ccctgcacgg 300 ctggaccggc accggcaaat cctatgtcag ctccctgctg gcgcactacc tcttccaggg 360 cggcctccgc agcccccgcg tgcaccactt ttctcccgtc ctccacttcc cccaccccag 420 ccacatcgag cgctacaaga aggatctgaa gagctgggtc caagggaacc tcactgcctg 480 tggccgctcc ctcttcctct tcgatgagat ggacaagatg cccccaggcc tgatggaagt 540 cctgcggcct ttcctgggct cctcctgggt ggtatacggg accaattacc gcaaagccat 600 cttcatcttc atcagatggc ttcttaaact cgggcatcat ggaagagcgc cttctanacg 660 caatggtgcc cttnctcccg gttcagcggg accacgttcc ggcaactgcg tgcttcaacg 720 aagcttggcc caacttgggc cctggaancc ca 752 <210> 502 <211> 526 <212> DNA <213> Homo sapiens <400> 502 gcgctcgccg cgctcgcact gaagcccggg ccctcgcgcg ccgcggttcg ccccgcagcc 60 tcgccccctg cccacccggg cggccgtagg gcggtcacga tgctgccgcc cttaccctcc 120 cgcctcgggc tgctgctgnt gctgctcctg tgcccggcgc acgtcggcgg actgtggtgg 180 gctgtgggca gccccttggt tatggaccct accagcatct gcaggaaggc acggcggctg 240 gccgggcggc aggccgagtt gtgccaggct gagccggaag tggtggcaga gctagctcgg 300 ggcgcccggc tcggngtgcg agagtgccag ttccagttcc gcttccgccg ntggaattgc 360 tccagccaca gcaaggcctt tggacgcatc ctgcaacagg acattcggga gacggccttc 420 gtgttcgcca tcactgcggc cggcgccagc cacgccgtca cgcaggcctg tnctatgggc 480 gagctgctgc agngcggctg ccaggcgccc cgctggcggg nccctc 526 <210> 503 <211> 772 <212> DNA <213> Homo sapiens <400> 503 gtgcgcgttg gggcggccgg ccaatgccgg accgcttcgg caccgcccgc ccgatccctc 60 cacccgtggg ccggcaatgg cgggcgcagt ttcgctcttg ggtgtggtgg ggctgctgct 120 tgtgtctgcg ctgtccgggg tcctaggaga ccgcgccaat cccgacctcc gggcacaccc 180 agggaacgca gcccaccccg gctctggagc cacggaaccc cggcggcgac caccgctcaa 240 ggatcaacgc gagcggaccc gggccgggtc gctgcctctg ggggcgctgt acaccgcggc 300 cgtcgcggct tttgtgctgt acaagtgttt gcaggggaaa gatgaaactg cggttctcca 360 cgaggaggca agcaagcagc agccactgca gtcagagcaa cagctggccc agttgacaca 420 acagctggcc cagacagagc agcacctgaa caacctgatg gcccagctgg accccctttt 480 tgagcggagc ttctgaacat gaagctatgg accatccacg agctgctgca agatagcaag 540 ccggacaagg atatggaggc ttcagaacca ggtgaaggct cgggaggcga gtctgctgga 600 ggtggagaca aagtctctga aactggaaca ttcctgatct ctccccacac agaggccagc 660 agacctcttc ctgaggactt ctggttaaag gaggacgagg aggaagttgg tgacagtcan 720 gcctgggang aacccacaaa ctggagcaca nagacatgga acctaactac tt 772 <210> 504 <211> 735 <212> DNA <213> Homo sapiens <400> 504 agcctgagaa gagcgtctcg cccgggagcg gcggcggcca tcgagaccca cccaaggcgc 60 gtccccctcg gcctcccagc gctcccaagc cgcagcggcc gcgccccttc agctagctcg 120 ctcgctcgct ctgcttccct gctgccggct gcgccatggc gttggcgttg gcggcgctgg 180 cggcggtcga gccggcctgc ggcagccggt actggcagtt gcagaatgaa gaagagtctg 240 gagaacctga acaggctgca ggtgatgctc ctccacctta cagcagcatt tctgcagaga 300 gcgcagcata ttttgactac aaggatgagt ctgggtttcc aaagccccca tcttacaatg 360 tagctacaac actgcccagt tatgatgaag cggagaggac caaggctgaa gctactatcc 420 ctttggttcc tgggagagat gaggattttg tgggtcggga tgatcttgat gatgctgacc 480 agctgangat aggaaatgat gggattttca tgttaacttt tttcatggca ttcctcttta 540 actggattgg gtttttcctg tctttttgcc tgaccacttc agctgcagga aggtatgggg 600 ccatttcagg atttggctct ctctaattaa atggatcctg attgtcaggt tttccaccta 660 tttccctgga tattttgatg gtcagtactg gctctgntgg tgntccttgg tttaagcttt 720 ctnctggttc tcaga 735 <210> 505 <211> 811 <212> DNA <213> Homo sapiens <400> 505 acgcgaaggc tctatcccac gaaaggactg ggtgcacccc agaacgagga cgcggagctt 60 ccctgttcca agcagcgatg cctggcggag cctgcgtgct ggtgatcgcg ctgatgttcc 120 tggcctgggg ggaagctcag gagtgctctc ctgggggaca ccagtttctt cggagtcctt 180 atagaagtgt ccgttttgac tcatggcacc tccagcagtc agctgttcaa gacctaatat 240 gtgaccattc cctctcccct ggatggtata gatttctcat ccttgacaga cctgccgaga 300 tgccaaccaa atgtgttgag atgaaccatt gtggaactca ggcccccatc tggctgtctc 360 tgagagattc agaaacactg ccatctcctg gggagatcaa gcaattgaca gcttgtgcaa 420 catggcagtt tttgttcagc actacaaaag actgctgtct ctttcaaatc ccagtgtctg 480 taagaaactg tgggaacttt tctgtatact tactacaacc aactcaggga tgtatgggct 540 actgtgcgga agggttcttt gccaagattg taaagtcccc ccacacgtga aagcatcaaa 600 acagacatct cacatttttc cactggacat aatgattgag tgtgttaaaa attctttggt 660 ttcctcaagt ccattcctgt tttaattaaa ggatgaagaa gctatttctg atgcacgatt 720 acacccatgt ggttctgatg aaactgaaac aggangtgat tgngttcgtc agctggctgg 780 ctcantggca ccttcacctg caggaaggcc a 811 <210> 506 <211> 831 <212> DNA <213> Homo sapiens <400> 506 gacccgccac ccgccgtagc ccgcgcgccc ctggcactca atccccgcca tgtgggggct 60 cctgctcgcc ctggccgcct tcgcgccggc cgtcggcccg gctctggggg cgcccaggaa 120 ctcggtgctg ggcctcgcgc agcccgggac caccaaggtc ccaggctcga ccccggccct 180 gcatagcagc ccggcacagc cgccggcgga gacagctaac gggacctcag aacagcatgt 240 ccggattcga gtcatcaaga agaaaaaggt cattatgaag aagcggaaga agctaactct 300 aactcgcccc accccactgg tgactgccgg gccccttgtg acccccactc cagcagggac 360 cctcgacccc gctgagaaac aagaaacagg ctgtcctcct ttgggtctgg agtccctgcg 420 agtttcagat agccggcttg aggcatccag cagccagtcc tttggtcttg gaccacaccg 480 aggacggctc aacattcagt caggcctgga ggacggcgat ctatatgatg gagcctggtg 540 tgctgaggag caggacgccg atccatggtt tcaggtggac gctgggcacc ccacccgctt 600 ctcgggtgtt atcacacagg gcaggaactc tgtctggagg tatgactggg tcacatcata 660 caaggtccag ttcagcaatg acagtcggac ctggtgggga agtaggaacc acagcagtgg 720 gatggacgca gtatttnctg gccaattcag acccagaaac ttcagtgctt gaaccttctg 780 gccggagccc caggtggggc ccgtttaatt nnctggttgc ccaaaacttg g 831 <210> 507 <211> 828 <212> DNA <213> Homo sapiens <400> 507 ggctaccttg tggtggttat tgggttagag aatgtgttgg tgctcaccaa gtctgtggtc 60 tcaaccccgg tagacctgga ggtgaagctg cggatcgccc aaggcctaag cagcgagagc 120 tggtccatca tgaagaacat ggccacggag ctgggcatca tcctcatcgg ctacttcacc 180 ctagtgcccg ccatccagga gttctgtctc tttgctgtcg tggggctggt gactgacttc 240 ttccttcaga tgctgttttt caccactgtc ctgtccattg acattcgccg gatggagcta 300 gcagacctga acaagcgact gccccctgag gcctgcctgc cctcagccaa gccagtgggg 360 cagccaacgc gctacgagcg gagcagcggc cggctggagg tgtgggactc cattgaaggg 420 gtgctgtgct gcagcagcga ggaggtctcc tcaggcatta ccgctctggt gttcttggac 480 aaagggattg tggctgcacg gctcaacggt tcccttgatt tcttctcctt ggagacccac 540 actgccctca gccccctgca gtttagaggg accccagggc ggggcagttc ccctgcctct 600 ccagtgtaca gcagcagcga cacagtggcc tgtcacctga cccacacagt gccctgtgca 660 caccaaaaac ccatcacagc cctgaaagcc gctgctgggc cgcttggtga ctgggagcca 720 agaccacaca cttgagagtg ttccgtctgg aggactcgtg ctgnctcttc accctttaag 780 gncacttaag gggccattaa cgaccgggta cattgaccca gancatgg 828 <210> 508 <211> 878 <212> DNA <213> Homo sapiens <400> 508 atcctcctag gacccggtcg gtagtcgtcg ccccagcccg ccgggggcgc agcgcccgag 60 ccgcggccct cgagacggga ccgagagcat catgggcagc actgtcccgc gctccgcctc 120 cgtgctgctt ctgctgctgc tcctgcgccg ggccgagcag ccctgcgggg ccgagctcac 180 cttcgagctg ccggacaacg ccaagcagtg cttccacgag gaggtggagc agggcgtgaa 240 gttctccctg gattaccagg tcatcactgg aggccactac gatgttgact gctatgtaga 300 ggacccccag gggaacacca tctacagaga aacgaagaag cagtacgaca gcttcacgta 360 ccgggctgaa gtcaagggcg tttatcagtt ttgcttcagt aatgggtttt ccaccttctc 420 tcacaagacc gtctactttg actttcaagt gggcgatgag cctcccattc tcccagacat 480 ggggaacagg gtcacagctc tcacccaggg cttcagggtc ttctgcctgt agctgccaaa 540 ggaagagaga atgagaaaag cccatctacc tcttaaaagc ccaggcccag tgggaatacg 600 tatcacctgc tcatgtccca tggatggagt ccgcctgcgt gaccatccat gaggcttctg 660 aaaacggtga ttgactccca gacgcattac cggctgcggg aggcccagga ccgggcccga 720 gcggaagacc ttaatagccc gagtctctta ctggtctgtt ggcgagacga ttgcccttgt 780 tcgtggtcaa gctttaatca ngtgctactg gttgaaaagc ttcttcacag aaaaacgacc 840 attaacangg cagtccattc tagccccggn attctgtt 878 <210> 509 <211> 813 <212> DNA <213> Homo sapiens <400> 509 gcagagtgca gggccacgtc gcttttgctg taccggggac cacgcgtctc atccatggct 60 tccgcggact cgcgccgggt ggcagatggc ggcggtgccg ggggcacctt ccagccctac 120 ctagacacct tgcggcagga gctgcagcag acggacccaa cgctgttgtc agtagtggtg 180 gcggttcttg cggtgctgct gacgctagtc ttctggaagt taatccggag cagaaggagc 240 agtcagagag ctgttcttct tgttggcctt tgtgattccg ggaaaacgtt gctctttgtc 300 aggttgttaa caggccttta tagagacact cagacgtcca ttactgacag ctgtgctgta 360 tacagagtca acaataacag gggcaatagt ctgaccttga ttgaccttcc cggccatgag 420 agtttgaggc ttcagttctt agagcggttt aagtcttcag ccagggctat tgtgtttgtt 480 gtggatagtg cagcattcca gcgagaggtg aaagatgtgg ctgagtttct gtatcaagtc 540 ctcattgaca gtatgggtct gaagaataca ccatcattct taatagcctg caataagcaa 600 gatattgcaa tggcaaaatc agcaaagtta attcaacagc agctggagaa agaactcaac 660 accttacgag ttacccgttc tgctgccccc agcacactgg acagttncag cactgcccct 720 gctcanctgg ggaagaaagg ccaagagttt gaattcttac aagttgcccc tcaaaagtgg 780 agttcctgga atgcaatgcc caaggttggn aaa 813 <210> 510 <211> 810 <212> DNA <213> Homo sapiens <400> 510 agctccagtc ctggcatctg cccgaggaga ccacgctccc ggagctctgc tgtcttctca 60 gggagactct gaggctctgt tgagaatcat gctttggagg cagctcatct attggcaact 120 gctggctttg tttttcctcc ctttttgcct gtgtcaagat gaatacatgg agtctccaca 180 aaccggagga ctacccccag actgcagtaa gtgttgtcat ggagactaca gctttcgagg 240 ctaccaaggc ccccctgggc caccgggccc tcctggcatt ccaggaaacc atggaaacaa 300 tggcaacaat ggagccactg gtcatgaagg agccaaaggt gagaagggcg acaaaggtga 360 cctggggcct cgaggggagc gggggcagca tggccccaaa ggagagaagg gctacccggg 420 gattccacca gaacttcaga ttgcattcat ggcttctctg gcaacccact tcagcaatca 480 gaacagtggg attatcttca gcagtgttga gaccaacatt ggaaacttct ttgatgtcat 540 gactggtaga tttggggccc cagtatcagg tgtgtatttc ttcaccttca gcatgatgaa 600 gcatgaggat gttgaggaag tgtatgtgta ccttatgcac aatggcaaca cagtcttcaa 660 catgtacagc tatgaaatga agggcaaatc agatacatcc agcaatcatg ctgtgctgaa 720 ctagccaaan gggatgaggt ttggctgcna atggcaatgg cgctnttcat ggggaccacc 780 aacgcttctt cacctttgca ggattcctgc 810 <210> 511 <211> 694 <212> DNA <213> Homo sapiens <400> 511 actccgtgct ggaagtagga ggagagtcag gactcccagg acagagagtg cacaaactac 60 ccagcacagc cccctccgcc ccctctggag gctgaagagg gattccagcc cctgccaccc 120 acagacacgg gctgactggg gtgtctgccc cccttggggg ggggcagcac agggcctcag 180 gcctgggtgc cacctggcac ctagaagatg cctgtgccct ggttcttgct gtccttggca 240 ctgggccgaa gcccagtggt cctttctctg gagaggcttg tggggcctca ggacgctacc 300 cactgctctc cgggcctctc ctgccgcctc tgggacagtg acatactctg cctgcctggg 360 gacatcgtgc ctgctccggg ccccgtgctg gcgcctacgc acctgcagac agagctggtg 420 ctgaggtgcc agaaggagac cgactgtgac ctctgtctgc gtgtggctgt ccacttggcc 480 gtgcatgggc actgggaaga gcctgaagat gaggaaaagt ttggaggagc agctgactca 540 ngggtggagg agcctangaa tgcctctctc caggcccaag tcgtgctctc cttcaggcct 600 accctactgc ccgctgcgtc ctgctggang tgcaagtgcc tgctgccttg tgcaatttgg 660 ncaatctgtg ggctctgtgg tatatgactg cttn 694 <210> 512 <211> 841 <212> DNA <213> Homo sapiens <400> 512 tatccagaat ggtgtttctg aagttcttct gcatgagttt cttctgccac ctgtgtcaag 60 gctacttcga tggccccctc tacccagaga tgtccaatgg gactctgcac cactacttcg 120 tgcccgatgg ggactatgag gagaacgatg accccgagaa gtgccagctg ctcttcaggg 180 tgagtgacca caggcgctgc tcccaggggg aggggagcca ggttggcagc ctgctgagcc 240 tcaccctgcg ggaggagttc accgtgctgg gccgccaggt ggaggatgct gggcgcgtgc 300 tggagggcat cagcaaaagc atctcctacg acctagacgg ggaagagagc tatggcaagt 360 acctgcggcg ggagtcccac cagatcgggg atgcctactc caactcggac aaatccctca 420 ctgagctgga gagcaagttc aagcagggcc aggaacagga cagccggcag gagagcaggc 480 tcaacgagga ctttctggga atgctggtcc acaccaggtc cctgctgaag gagacactgg 540 acatctctgt ggggctcagg gacaaatacg agctgctggc cctcaccatt aggagccatg 600 ggacccgact aggtcggctg aaaaatgatt atcttaaagt ataggtggaa ggatacaaat 660 gctagaaaga gggaatcaaa tcagccccgt tttggaaggt gggggacaga agatggggct 720 catttncccc atacctacta tttttttata tcccganttg cactttgaga atncatctaa 780 ggcatctttt aaaagagaaa aattggaccc ttgaatgact tggttttaag tttggttttg 840 n 841 <210> 513 <211> 496 <212> DNA <213> Homo sapiens <400> 513 gagcggggcc ggcagagcgc gcggcgtcgg tgcccttgac catggcggcg gctgcgcttc 60 tgctggggct ggcgctgctg gcaccgcggg cggccggcgc gggcatgggc gcgtgctatg 120 acggcgcagg gcgcccgcag cgctgcctgc cggtgttcga gaacgcggcg tttgggcggc 180 tcgcccaggc ctcgcacacg tgcggcagcc cgnccgagga cttctgtccc cacgtgggcg 240 ccgcgggcgc gggggctcat tgccagcgct gcgacgccgc cgacccccag cgccaccaca 300 acgcctccta cctcaccgac ttccacagcc aggacgagag cacctggtgg cagagcccgt 360 ccatggtctt cggcgtgcag taccccacct ctgtcaacat cacccttcgt ctanggaagg 420 cttatgagat cacgtatgtg angctgaagt tccacaccag tcgccctgag agctntgcca 480 tctacaagcg cagccg 496 <210> 514 <211> 745 <212> DNA <213> Homo sapiens <400> 514 ctccccgccg ccgccggtcc cggtgcgcgc ccatccctgc ccgcagcccc gcgcgccggc 60 cgagtcgctg agccgcggct gccggacggg acgggaccgg ctaggctggg cgcgcccccc 120 gggccccgcc gtgggcatgg gcgcactggc ccgggcgctg ctgctgcctc tgctggccca 180 gtggctcctg cgcgccgccc cggagctggc ccccgcgccc ttcacgcggc tactacctgg 240 agatgctgat cgggaccccc ccgcagaagc tacagattct cgttgacact ggaagcagta 300 actttgccgt ggcaggaacc ccgcactcct acatagacac gtactttgac acagagaggt 360 ctagcacata ccgctccaag ggctttgacg tcacagtgaa gtacacacaa ggaagctgga 420 cgggcttcgt tggggaagac ctcgtcacca tccccaaagg cttcaatact tcttttcttg 480 tcaacattgc cactattttt gaatcaggga atttcttttt gcctgggatt caatggaatg 540 gaatacttgg cctagcttat gccacacttg ccaagccatc aagttctctg gagaccttct 600 tcgacttcct ggtgacacaa gcaaacattc ccaacgtttt cttcatgcaa gatgcgtgga 660 gcccggtttg cccgttgctn ggatcttggg aaccaacgga aggtaagtct ttgnctttgg 720 gtgggaaatt gaanccaaag tttgg 745 <210> 515 <211> 668 <212> DNA <213> Homo sapiens <400> 515 agatcgcgcc aggagaggag gagagctcgg gcgagcggcg agcacaggcc acgggagctg 60 agcgcagcag agagcagccg gagtccgcgc ctgactccgc gcgggtcctg agccggccgc 120 agcttgccag gatccccggc gtccttctcg cgccgcttca cgaagagggc gccttcgccg 180 ctcgcccagc cggagtgcgc acgggcccgc tggaaaccgc actcgccgct ccctgggcag 240 gccggggcac ccgggcacgc agggcgcgcc tggcgagcgc cccgggaggc ggcgtgcagg 300 accagcggcg gccgtgcagg cggaggactt cggcgcggct cctcctgggt gtgaccccgg 360 gcgcgcccgc cgcgcgacga tgagggcgcg gccgcaggtc tgcgaggcgc tgctcttcgc 420 cctggcgctc cagaccggcg tgtgctatgg catcaagtgg ctggcgctgt ccaagacacc 480 atcggccctg gcactgaacc agacgcaaca ctgcaagcag ctggagggtc tggtgtctgc 540 acaggtgcag ctgtgccgca gcaacctgga gctcatgcac acggtggtgc acgccgnccg 600 cgaggtcatg aaaggccttg tcgncgggcc tttgcccaca tgcgcttgga acttgctnct 660 tccattga 668 <210> 516 <211> 842 <212> DNA <213> Homo sapiens <400> 516 acgcgtggcg cgatggcggc ggccccacgc gcgggccggc ggcgcgggca gccgctcctg 60 gcgctgctgc ttctgctgct ggcgccactg ccgccggggg ccccgccggg cgccgacgcc 120 tactttcccg aggagcgctg gagcccggag tcgcccctgc aggcgccgcg cgtgctcatc 180 gcgctgttgg cgcgaaacgc ggcccacgcg ttgcccacca cgctgggcgc actcgagcgg 240 ctgcggcacc cgcgggagcg cacggcgcta tgggtggcta cggaccacaa catggataac 300 acgtcaactg tgctgcggga gtggctggtg gccgtgaaga gtttgtacca ttccgtggag 360 tggcggccag cagaggagcc caggtcctac ccggacgagg aaggcccgaa acactggtct 420 gactcacgct acgagcatgt catgaagttg cgccaggcag ccctgaaatc agctcgagac 480 atgtgggctg attacatcct gtttgtagat gcggacaacc tgatcctcaa ccctgacaca 540 ctgagcctgc tcatcgctga gaacaagacg gtggtcgccc ccatgctgga ttcccgggct 600 gcgtactcca acttctggtg tggaatgact tcccagggct actacaaagc gcacacctgc 660 ctacatncct atccgcaagc gagaaccgcc cgggcttgct ttgcaagttc ccattggtgc 720 aacttgaacc tttcctgaat cgaacttgcc ggaaaggcgg gngttccaag gaaacccttg 780 gnccttttta cccaaccttt aacccttgaa cttacaacct tgggnccctt tttgacccaa 840 cc 842 <210> 517 <211> 661 <212> DNA <213> Homo sapiens <400> 517 gctgggcgca cggcgcggag ccggccggag ctcgaggccg gcggcggttg gagagcgacc 60 cgggcggcct cgtagcgggg ccccggatcc ccgagtggcg gccggagcct cgaaaagaga 120 ttctcagcgc tgattttgag atgatgggct tgggaaacgg gcgtcgcagc atgaagtcgc 180 cgcccctcgt gctggccgcc ctggtggcct gcatcatcgt cttgggcttc aactactgga 240 ttgcgagctc ccggagcgtg gacctccaga cacggatcat ggagctggaa ggcagggtcc 300 gcagggcggc tgcagagaga ggcgccgtgg agctgaagaa gaacgagttc cagggagagc 360 tggagaagca gcgggagcag cttgacaaaa tccagtccag ccacaacttc cagctggaga 420 gcgtcaacaa gctgtaccag gacgaaaagg cggttttggt gaataacatc accacaggtg 480 agaggctcat ccgagtgctg caagaccagt taaagaccct gcagaggaat tacggcaggc 540 tgcagcagga tgtcctccag tttcagaaga accagaccaa cctggagagg aagttctcct 600 acgacctgag ccagtgcatc aatcagatga aggangtgaa ggaacantgt gangagccaa 660 t 661 <210> 518 <211> 731 <212> DNA <213> Homo sapiens <400> 518 aagcctccca ttacggagca cgagagagtc catgaaggtc cccgcgactc ccggactgga 60 gaaaacggct cttgcgatgg ggcgaagtcc gagctgcggc gggcgttggt ccgtgcaggg 120 aagtgggaat cgttaggttc gttctggacc cgccgcccca tggcccaggc gtctcgctca 180 ggtagcctgc ctccactcgt tatcgtgccc ccgctgaggg cgcaacccgg gggcactggg 240 gaggagcagt gggagagaag tcgaacgggc ggtcttcgct gggaggttca ctgctggccg 300 agcggaactt ctggagggac gccgtggtgg ccgacgccgg cggatgtgag cgaggactac 360 gaggctgatg ctgcggcctg gaggcggggg cccgcaggtg gcggcccgat ccctcccgcg 420 ctgcagcgtc tccgggcggt gttgctgcgg ctgcatcgcg agcgggagca gctcctccag 480 gcccgagact gcgcctacca cctacagtcg gctgtgcgac tcatgaagac cctgagtcct 540 ggctcgccat ccggcggccc tagccccttg ccccagtggt accgcgacct gcagctgcac 600 ccttcccaag gggcggttct gcgaatcggc cctggggaga ctctcgagcc gnttgctgct 660 agcgcgcccc atcggactag cccgnccaat gcctggagct tgtcatcgag atcaactttn 720 cgctctcggc c 731 <210> 519 <211> 792 <212> DNA <213> Homo sapiens <400> 519 actctggcac cactctccag gctgccatgg ggcccagcac ccctctnctc atcttgttcc 60 ttttgtcatg gtcgggaccc ctccaaggac agcagcacca ccttgtggag tacatggaac 120 gccgactagc tgctttagag gaacggctgg cccagtgcca ggaccagagt agtcggcatg 180 ctgctgagct gcgggacttc aagaacaaga tgctgccact gctggaggtg gcaganaagg 240 agcgggaggc actcagaact gaggccgaca ccatctccgg gagagtggat cgtctggagc 300 gggaggtana ctatctggag acccagaacc cagctctgcc ctgtgtagag tttgatgaga 360 aggtgactgg aggccctggg accaaaggca agggaagaag gaatgagaag tacgatatgg 420 tgacaggtaa acaatctgaa agcaggcccc taactcttct cagaaccgat attcttcctt 480 ccttgcttct tactcttttt ttcactttgt cccagtccat tgtggctctg tcttctggaa 540 tctgttttag ggaaacctct gtaatgccag gtctattaag gagaggttct ggggatccag 600 gccgctgtgg tacccgctct ttctcaattc tccctaagat tggaggctac cgctgggcaa 660 atgctcacta ttctncagat cacccaccct gggggagttc ctgctggagg catctaattc 720 ttgcctctat ttnctttcct gggcttttct catcagactg nggctacaca atctntcagt 780 gagatcaatg aa 792 <210> 520 <211> 763 <212> DNA <213> Homo sapiens <400> 520 actgtccact tccacgacaa ctctggagat gtcttccatg ctcacagttc ggtcctcaac 60 tttgccacta acagagacga ctttgtgcag atcgggaagg gccccaccaa caacacctgc 120 gttgtccgca cagtcagcgt gggcctgaca ctgctccgtg tgtgggacgc agagcacccg 180 ggcctctcgg acttcatgcc cctgcctgtc ctacaggcca tctccccaga gctgtctggg 240 gccatggtgg tgggggacgt gctctgtctg gccactgttc tgaccagcct ggaaggcctc 300 tcaggaacct ggagctcctc aaccaacagc atcctccaca tcgaccccaa gacgggtgtg 360 gctgtggccc gggccgtggg atccgtgacg gtttactatg aggtcgctgg gcacctgagg 420 acctacaagg aggtggtggt cagcgtccct cagaggatca tggcccgtca cctccacccc 480 atccagacaa gcttccagga ggctacagcc tccaaagtga ttgttgccgt gggagacaga 540 agctctaacc tgagaggcga gtgcaccccc acccagaggg aagtcatcca ggccttgcac 600 ccagagaccc tcatcagctg ccagtcccag ttcaagccgg ccgtctttga tttcccatct 660 caagatgtgt tcaccgtgga gccacagttt gacactgntc tnggncagta cttctgctca 720 atcacaatgc acaggctgac ggacaagcag cggaagcacc tga 763 <210> 521 <211> 778 <212> DNA <213> Homo sapiens <400> 521 agcaacgacg ccgggcagcg ggagcggcgg ccgcgccatg tggctgctgg ggccgctgtg 60 cctgctgctg agcagcgccg cggagagcca gctgctcccc gggaacaact tcaccaatga 120 gtgcaacata ccaggcaact tcatgtgcag caatggacgg tgcatcccgg gcgcctggca 180 gtgtgacggg ctgcctgact gcttcgacaa gagtgatgag aaggagtgcc ccaaggctaa 240 gtcgaaatgt ggcccaacct tcttcccctg tgccagcggc atccattgca tcattggtcg 300 cttccggtgc aatgggtttg aggactgtcc cgatggcagc gatgaagaga actgcacagc 360 aaaccctctg ctttgctcca ccgcccgcta ccactgcaag aacggcctct gtattgacaa 420 gagcttcatc tgcgatggac agaataactg tcaagacaac agtgatgagg aaagctgtga 480 aagttctcaa gaacccggca gtgggcaggt gtttgtgact tcagagaacc aacttgtgta 540 ttaccccagc atcacctatg ccatcatcgg cagctccgtc atttttgtgc tggtggtggc 600 cctgctggca ctggtcttgc accaccagcg gaagcggaac aacctcatga cgctgcccgt 660 gcaccggctg cagcaccctg tgctgctgtc ccgcctgtgg tcctggacac ccccaccact 720 gnaacgtcac ctacaacgtc aataatggca tncagtatgt ggccagccag gcngagca 778 <210> 522 <211> 718 <212> DNA <213> Homo sapiens <400> 522 aaaaactgat gtttgtattc aatttcttca tatttctggg cggggcctgc ctgctggcca 60 tcggcatctg ggtcatggtg gaccccaccg gcttccggga gatcgtggct gccaatcctc 120 tgctcctcac gggcgcctac atcctcctgg ccatgggggg cctgctcttt ctgctcggct 180 tcctgggctg ctgcggggcc gtccgtgaga acaagtgtct gctgctattt ttcttcctgt 240 tcatcctgat catcttcctg gcagagctct cagcagccat cctggccttc atcttcaggg 300 aaaatctcac ccgagaattc ttcaccaagg agctcaccaa gcactaccag ggcaataacg 360 acacagacgt cttctctgcc acctggaact cggtcatgat cacatttggt tgctgcgggg 420 tcaacgggcc tgaagacttt aagtttgcat ctgtgtttcg actcctgacc ctggatagtg 480 aagaggtgcc ggaggcctgc tgccggaggg aaccccaaag tcgggacggg gtcctgctga 540 gccgggagga gtgcctcctg ggaaggagcc tattcctaaa caagcagggc tgttacacgg 600 tgatcctcaa caccttcgag acctacgtct acttggccgg agcccttgcc atcggggtac 660 tggccatcga gcttttcgcc atgatctttg ncatgtgcct ctttcngggc attcanta 718 <210> 523 <211> 757 <212> DNA <213> Homo sapiens <400> 523 gcgccggctc ggacgcggcc ggctaccgag ccctttgtga gggctgtgag ctgcgcctga 60 cggtggcacc atgagcagct caggtggggc gcccggggcg tccgccagct ctgcgccgcc 120 cgcgcaggaa gagggcatga cgtggtggta ccgctggctg tgtcgcctgt ctggggtgct 180 gggggcagtc tcttgcgcga tctctggcct cttcaactgc atcaccatcc accctctgaa 240 cattgcggcc ggcgtgtgga tgatcatgaa tgccttcatc ttgttgctgt gtgaggcgcc 300 cttctgctgc cagttcatcg agtttgcaaa cacagtggcg gagaaggtgg accggctgcg 360 ctcctggcag aaggctgtct tctactgcgg gatggcggtc gttcccatcg tcatcagcct 420 gaccctgacc acgctgctgg gcaacgccat cgcctttgct acgggggtgc tgtacggact 480 ctctgctctg ggcaaaaagg gcgatgcgat ctcctatgcc aggatccagc agcagaggca 540 gcaggcggat gaggagaagc tcgcggagac cctggagggg gagctgtgaa gggctgggcg 600 cccctccctt cctgtcccct cttctggctc tgtgtgggtc caagtgaggc ctggactgtc 660 cacgctgang cacaacctgg aaaggggcct ttgcacgtgt cctacacctg gagtcctctg 720 ctcctttctc anactgctta accangaacc actgctt 757 <210> 524 <211> 754 <212> DNA <213> Homo sapiens <400> 524 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa attcgggccg ggcctcgctg cggcggcgac 60 tgagccaggc tgggccgcgt ccctgagtcc cagagtcggc gcggcgcggc aggggcagcc 120 ttccaccacg gggagcccag ctgtcagccg cctcacagga agatgctgcg tcggcggggc 180 agccctggca tgggtgtgca tgtgggtgca gccctgggag cactgtggtt ctgcctcaca 240 ggagccctgg aggtccaggt ccctgaagac ccagtggtgg cactggtggg caccgatgcc 300 accctgtgct gctccttctc ccctgagcct ggcttcagcc tggcacagct caacctcatc 360 tggcagctga cagataccaa acagctggtg cacagctttg ctgagggcca ggaccagggc 420 agcgcctatg ccaaccgcac ggccctcttc ccggacctgc tggcacaggg caacgcatcc 480 ctgaggctgc agcgcgtgcg tgtggcggac gagggcagct tcacctgctt cgtgagcatc 540 cgggatttcg gcagcgctgc cgtcagcctg caggtggccg ntccctactc gaagcccagc 600 atgaccctgg agcccaacaa ggacctgcgg ccaggggaca tggtgaccat cacgtgcttc 660 aactaccagg gctaccctga ggctgangtg ttctggcagg atgggcaagg gtgttgcccc 720 ttgactggca acgttgacca cnttngcaaa atgg 754 <210> 525 <211> 895 <212> DNA <213> Homo sapiens <400> 525 ctctttaagg tgcccgaggc tcgcgggcgc tgcgctgagg ggacggcggg aggcgcggcc 60 tggcctcgca ctcaaagccg ccgcagcgcg ccccgggctc ggccgacccg gcggggatct 120 aggggtgggc gacttcgcgg gaccgtggcg catgtttcct gggagttact gatcatcttc 180 tttgaagaaa catgaagtta cactatgttg ctgtgcttac tctagccatc ctgatgttcc 240 tgacatggct tccagaatca ctgagctgta acaaagcact ctgtgctagt gatgagagca 300 aatgcctcat tcaggagctc tgccagtgcc ggccgggaga aggcaattgc tcctgctgta 360 aggagtgcat gctgtgtctt ggggcccttt gggacgagtg ctgtgactgt gttggtatgt 420 gtaatcctcg aaattatagt gacacacctc caacttcaaa gagcacagtg gaggagctgc 480 atgaaccgat cccttctctc ttccgggcac tcacagaagg agatactcag ttgaattgga 540 acatcgtttc tttccctgtt gcagaagaac tttcacatca tgagaatctg gtttcatttt 600 tagaaactgt gaaccagcca caccaccaga atgtgtctgt ccccagcaat aatgttcacg 660 cgccttattc cagtgacaaa agaacacatg tgtactgtgg tttattttga tgactgcatg 720 tccatacatc agtgtaaaaa tatcctgtga agtncatggg aagcattcca aatatcggtt 780 gggtttcata atgcctgctt gcgaatgcat tgggtccaga atgtattgac tatggtangt 840 aaaactggca aatgtntgaa ctgcatgttt aaagaagaca aatgccaacc aanct 895 <210> 526 <211> 650 <212> DNA <213> Homo sapiens <400> 526 aagtggccgc cggcgtccgg gtacccgagg gctctcccgc gttgctggca ccgctggcgc 60 cgcggtctcg tagcgcatgg gcctcctccg aggcgggctc ccatgcgctc gggccatggc 120 gcgcctgggc gctgtgcgct cccactactg cgccctgctg ctggccgcgg cgctggccgt 180 ctgcgccttc tactacctcg gctcaggccg ggagaccttc tccagcgcca ccaagaggct 240 gaaggaggcc cgcgccgggg ctcccgccgc gccctcgccg cccgcgctgg agctagcgcg 300 gggctccgtg gcgccagccc ccggcgcgaa ggccaagagc ttggagggcg gcggtgccgg 360 gccggtggac taccacctgc tgatgatgtt caccaaggcg gagcacaatg ccgcgctgca 420 ggccaaggcc cgcgtcgcgc tgcgctcact gctgcgcctc gccaagttcg aggcgcacga 480 ggtgcttaac cttcacttcg tgagcgagga ggccagccgc gaggtggcca agggcctgct 540 gcgggagctc ctgccgccgc cgctggcttc aagtgcaagg tcatcttnca cgatgttgct 600 gtgctgacgg ataagctctt cccatcgtgg angccatgca gaagcacttn 650 <210> 527 <211> 810 <212> DNA <213> Homo sapiens <400> 527 gcgaatgcga acctggcccg tgcggaaagg gcgcggagag ccccggcgcg gagcaggcgg 60 gggacggtat tcagaattcg agcgcaggag ctccgcttct ccacctgctc ccggggagct 120 attgggatcc agagaatcac ccgctgatgg tttttgccca ggcctgaaac aaccagagag 180 ctacgggaaa ggaagggctt ggcttgccag aggaattttc caagtgctca aacgccaggc 240 ttacggcgcc tgtgatccgt ccaggaggac aaagtgggat ttgaaggtcc actccacttc 300 tgctcatggc gggccagggc ctgcccctgc acgtggccac actgctgact gggctgctgg 360 aatgcctggg ctttgctggc gtcctctttg gctggccttc actagtgttt gtcttcaaga 420 atgaagatta ctttaaggat ctgtgtggac cagatgctgg gccgattggc aatgccacag 480 ggcaggctga ctgcaaagcc caggatgaga ggttctcact catcttcacc ctggggtcct 540 tcatgaacaa cttcatgaca ttccccactg gctacatctt tgaccggttc aagaccaccg 600 tggcacgcct catagccata tttttctaca ccaccgccac actcatcata gccttcacct 660 ctgcaggctc aacccgtgct tgtcttctgg ccatgccaat gctcaccatt gggggaatcc 720 tgtttctcat caccaacctg cagattggga acctatttgg ncaacaccgn tcgaccatca 780 tactttgnac aatgggagca tttgactctt 810 <210> 528 <211> 771 <212> DNA <213> Homo sapiens <400> 528 agcagcgcag gtgagcgccg cttccggggt cgggcgcctg gatagctgcc ggctccggct 60 tccacttggt cggttgcgcg ggagactatg gcgtcctcct cggtcccacc agccacggta 120 tcggcggcga cagcaggccc cggcccaggt ttcggcttcg cctccaagac caagaagaag 180 catttcgtgc agcagaaggt gaaggtgttc cgggcggccg acccgctggt gggtgtgttc 240 ctgtggggcg tagcccactc gatcaatgag ctcagccagg tgcctccccc ggtgatgctg 300 ctgccagatg actttaaggc cagctccaag atcaaggtca acaatcacct tttccacagg 360 gaaaatctgc ccagtcattt caagttcaag gagtattgtc cccaggtctt caggaacctc 420 cgtgatcgat ttggcattga tgaccaagat tacttggtgt cccttacccg aaaccccccc 480 agcgaaagtg aaggcagtga tggtcgcttc cttatctcct acgatcggac tctggtcatc 540 aaagaagtat ccagtgagga cattgctgac atgcatagca acctctncaa ctatcaccag 600 tacattgtga agtgccatgg caacacgctt ctgccccaat tcctggggat gtaccgagtc 660 aatgtggaca acgaagacag ctacatgctt gtgatgccaa tatgtttagc caccgcttnc 720 tgtgcacang aagtatgacc tcaagggttc cctaatgtcc cgggagccan c 771 <210> 529 <211> 745 <212> DNA <213> Homo sapiens <400> 529 ggactcggca ggcagcgggg accagggctg gcaggttaag cctctggggg tggatcctga 60 aaggtggtcc agccgcctgg ccctgcgtgg gaccctccac ctggcagcag acagggtctc 120 gctctgtcac acaggctgga gtgcagtggt gtgatcttgg ctcatcgtaa cctccacctc 180 ccgggttcaa gtgattctca tgcctcagcc tcccgagtag ctgggattac aggtggtgac 240 ttccaagagt gactccgtcg gaggaaaatg actccccagt cgctgctgca gacgacactg 300 ttcctgctga gtctgctctt cctggtccaa ggtgcccacg gcaggggcca cagggaagac 360 tttcgcttct gcagccagcg gaaccagaca cacaggagca gcctccacta caaacccaca 420 ccagacctgc gcatctccat cgagaactcc gaagaggccc tcacagtcca tgcccctttc 480 cctgcagccc accctgcttc ccgatccttc cctgacccca ggggcctcta ccacttctgc 540 ctctactgga accgacatgc tgggagatta catcttctct atggcaagcg tgacttcttg 600 ctgagtgaca aagcctctag cctcctctgc ttcagcacca ggaggagagc ctggctcaag 660 gccccccgct tgttagccac ttctgtcacc ttctggtgga gccctcagaa cataacctgg 720 ccantgcccg ncagcttnac cttct 745 <210> 530 <211> 750 <212> DNA <213> Homo sapiens <400> 530 gaaattcagg ttaacgccat tgataaaggg attccttcca tggcaggtca cagcatggtc 60 ctggtggaaa ttctggacgt gaatgacaat gtccctgaag taatggttac ttcactgtcg 120 ctccctgtgc aagaggatgc tcaggtgggt accgtcattg ccctgattag cgtgtcggat 180 cgtgactctg gagccaatgg acaggtcatc tgctcactga cacctcatgt tcccttcaag 240 ctggtgtcca cctacaagaa ttactactcg ttggtgctgg acagcgccct ggaccgcgag 300 agcgtgtcgg cctatgagct ggtggtgact gcgcgggatg ggggctcgcc ttcgctgtgg 360 gccacggcta gagtgtccgt ggaggtggcc gacgtgaacg acaatgcgcc tgcgttcgcg 420 cagcccgagt acacagtgtt cgtgaaggag aacaacccgc cgggctgcca catcttcacg 480 gtgtcggcat gggacgcgga cgcgcagaag aacgcgctgg tgtcctactc gctggtggag 540 cggcgggtgg gcgagcacgc actgtcgagc tacgtgtcgg tgcacgcgga gagcggcaag 600 gtgtacgcgc ttgcaacccg ctagaccacg angagctgga gcttgcttgc agtttccagg 660 tgagccgccg ccgccgacgc ccnggcgttg ccggcctttt ggggcaagna aaccgtggac 720 gcttgcaagg tggttncgtg gcttgggacc 750 <210> 531 <211> 775 <212> DNA <213> Homo sapiens <400> 531 acatcctccg gctgcccgcg cacctctcca cgccggcccc gttccgcggc tcgccctcgg 60 ctgcgctcgg ctcccgcggg cgctcggccc cgagcccctc ctccccctac ccgccggccg 120 gacagggagg agccaatggc tgggcctgcc atccacaccg ctcccatgct gttcctcgtc 180 ctcctgctgc ccctggagct gagcctggca ggcgcccttg cacctgggac ccctgcccgg 240 aacttccctg agaatcacat tgacctccca ggcccagcgc tgtggacgcc tcaggccagc 300 caccaccgcc ggcggggccc gggcaagaag gagtggggcc caggcctgcc cagccaggcc 360 caggatgggg ctgtggtcac cgncaccagg caggcctcca ggctgccaga ggctgagggg 420 ctgctgcctg agcagagtcc tgcaggcctg ctgcaggaca aggacctgct cctgggactg 480 gcattgccct accccgagaa ggagaaccga cctccaggtt gggagaggac caggaaacgc 540 agcagggagc acaagagacg cagggacagg ttgaggctgc accaaggccg agccttggtc 600 cgaggtccca gcttcctgat gaagaaggca gagctcttcg aagcccaagt gctggatgca 660 gccatggagg aatcctcacc agcctggcgc ccacatgttc tttctcacac ctttgangca 720 gcacctgcac agaagagtcc ctgatccttg nccgtaactt ccttgnggcc caaca 775 <210> 532 <211> 682 <212> DNA <213> Homo sapiens <400> 532 ctgctctggg gcggcattgc cagccggctg taggcattca gggcagtgtc ttctgcatct 60 cctaggaacc tcgggagcgg cagctccggc gcctggtagc gagaggcggg ttccggagat 120 cccggcctca cttcgtccca ctgtggttag gggtgagtcc tgcaaatgtt aagtgatttg 180 ctcaaggtgc ccatttcgca ggaattggag cccaggccag ttctctgagc ctatcattag 240 ggctaaagga gtgcgtgatc agaatggtgt ctggacggtt ctacttgtcc tgcctgctgc 300 tggggtccct gggctctatg tgcatcctct tcactatcta ctggatgcag tactggcgtg 360 gtggctttgc ctggaatggc agcatctaca tgttcaactg gcacccagtg cttatggttg 420 ctggcatggt ggtattctat ggaggtgcgt cactggtgta ccgcctgccc cagtcgtggg 480 tggggcccaa actgccctgg aaactcctcc atgcagcgct gcacctgatg gccttcgtcc 540 tcactgttgt ggggctggtt gctgtcttta cgtttcacaa ccatggaagg actgccaacc 600 tctactncct tcacagctgg ctgggcatca ccactgnctt cctcttcgcc tgccantggt 660 tcctgggctt tgctgtcttc ct 682 <210> 533 <211> 744 <212> DNA <213> Homo sapiens <400> 533 gttcgcgcag gtgcggcgcc tgggtcccca tggcgctgtg gcgcggctcc gcgtacgcgg 60 gcttcctggc gctggccgtg ggctgcgtct tcctgctgga gccagagctg ccaggctcgg 120 cgctgcgctc tctctggagc tcgctgtgtc tggggcccgc gcctgcgccc ccgggacccg 180 tctcccccga gggccggttg gcggcagcct gggacgcgct tatcgtgcgg ccagtccggc 240 gctggcgccg cgtggcagtg ggagtcaatg catgtgttga tgtggtgctc tcaggggtga 300 agctcttgca ggcacttggc cttagtcctg ggaatgggaa agatcacagc attctgcatt 360 caaggaatga tctggaagaa gccttcattc acttcatggg gaagggagca gctgctgagc 420 gcttcttcag tgataaggaa acttttcacg acattgccca ggttgcgtca gagttcccag 480 gagcccagca ctatgtagga ggaaatgcag ctttaattgg acagaaattt gcagccaact 540 cagatttaaa ggttcttctt tgcggtccag ttggtccaaa gctacatgag cttcttgatg 600 acaatgtctt tgttccacca gagtcattgc angaagtgga tgagttccac ctcattttag 660 agtatcaagc angggaagag tggggccaag ttaaaaagct tcccatgcca acccgatttc 720 atcttctttt nacgaanctt tttc 744 <210> 534 <211> 877 <212> DNA <213> Homo sapiens <400> 534 gcacatgcgc cttgagggaa gatggcacct gccggctgct gctgctgctg ctgcttctgg 60 ggcggcgctg tggccgccgc gggcgccgcc cggcgtgtcc tgctgctgct gctgctgggg 120 gtcctgtccg cccggctgcg gccaggcgcc ctggccaccg agcactactc gccgctctcc 180 ctgctcaagc aggagctgca gcaccggcag cagcaggagg ccccggcggg cggcggcggc 240 tgcagcccgc agtccgggga ctggggggac cagtactctg ccgagtgcgg cgagtcatcc 300 tttttgaact tccatgactc agactgcgaa cccaagggat catcaccctg tgactccttg 360 ctttccctca acactgagaa gattctgagc caggccaagt ctattgcaga acagaagaga 420 ttcccgtttg ccactgataa tgacagcaca aatgaagagt tagctattgc ttatgtcttg 480 attggcagtg gtctgtatga tgaagcaata cggcattttt caacaatgct tcagattctg 540 tcccctctgg gacgaattaa tgaagcagtg aatgacctca ctaaagctat ccaactgcag 600 ccctcagcac ggctgtacag acatcgggga accctgtact tcatatcaga ggactatgca 660 acagcccatg aagactttca gcagtcctta gaactgaaca aaaaccagcc tatagctatg 720 ctatacaaag ggttaacttt cttttacaga ggactttttg aaggaactat tgaatccttc 780 aaagaacttt gaagcagaaa agttgacttt attgatgcat ataaaagtct anggcaggca 840 tntngagaac tgggcaattt taaacagccc ttgaaac 877 <210> 535 <211> 811 <212> DNA <213> Homo sapiens <400> 535 atgcgctcgc atcatggcgg ctgagtgggc ttctcgtttc tggctttggg ctacgctgct 60 gattcctgcg gccgcggtct acgaagacca agtgggcaag tttgattgga gacagcaata 120 tgttgggaag gtcaagtttg cctccttgga attttcccct ggatccaaga agttggttgt 180 agccacagag aagaatgtga ttgcagcatt aaattcccga actggggaga tctatgtgat 240 cactgtgtcc aatggaggcc gaatcatgcg ttcctgggag actaacatcg ggggcctgaa 300 ctgggagata accctggaca gtggcagttt ccaggcactt gggctggttg gcctgcagga 360 gtctgtaagg tacatcgcag tcctgaagaa gactacactt gccctccatc acctctccag 420 tgggcacctc aagtgggtgg aacatctccc agaaagtgac agcatccact accagatggt 480 gtattcttac ggctctgggg tggtgtgggc cctcggagtt gttcccttca gccatgtgaa 540 cattgtcaag tttaatgtgg aagatggaga gattgttcag caggttaggg tttcaactcc 600 gtggctgcag cacctgtctg gagcctgtgg tgtggtggat gaagcttgtc ctggtgtgtc 660 ctgacccgag ctcacgttcc cttcaaactt tggcttttgg agacngaatg ggaatttgag 720 acagatccca ctggaatctc tcacttaana atttggaaat ggattccaac cccgggtcct 780 ggctacccag ccaacccagn ggacnctttc c 811 <210> 536 <211> 798 <212> DNA <213> Homo sapiens <400> 536 ttctaataac gtcacgtcga taaggggctt aggattgcat ctggcctgtg taagccctct 60 gagttctgcg gttcttagag ttcccttttc agcactatag ctctgccttg ttcccttgtt 120 cctccttctg gcgccccgtg ctgtgccccc tgcaggagtc caagctgtcc ccatgctgcg 180 ttctggtccg gccgcccctc ccgtggtgtg gccctggccg acccccctcc tgcgccccgc 240 ttttctcgca gaagctgctc tttgccggct cccgctctca gctggtgcag ctgcccgtgg 300 ccgactgcat gaagtatcgc tcctgtgcag actgtgtcct cgcccgggac ccctattgcg 360 cctggagcgt caacaccagc cgctgtgtgg ccgtgggtgg ccactctgga tctctactga 420 tccagcatgt gatgacctcg gacacttcag gcatctgcaa cctccgtggc agtaagaaag 480 tcaggcccac tcccaaaaac atcacggtgg tggcgggcac aaacctggtg ctgccctgcc 540 acctctcctc caacttgggc catgcccgct ggacctttgg gggccgggaa ctgcctgcgg 600 aacagccggg tccttcctct acaatgccgg ctccaagccc tggttgttga tgggtgccca 660 nccccgccat gccggggcct aacacttgct tttcaaaaga acaagggggg nccggctggn 720 tgcttaaagg taccttgttg ggtgttcttg gcnaggcccn tcggtgaact tggaaggccg 780 gggcccccct gnaaaaac 798 <210> 537 <211> 721 <212> DNA <213> Homo sapiens <400> 537 atagaaggaa gaggagcgaa catggcagcg cgttggcggt tttggtgtgt ctctgtgacc 60 atggtggtgg cgctgctcat cgtttgcgac gttccctcag cctctgccaa aagaaagaag 120 gagatggtgt tatctgaaaa ggttagtcag ctgatggaat ggactaacaa aagacctgta 180 ataagaatga atggagacaa gttccgtcgc cttgtgaaag ccccaccgag aaattactcc 240 gttatcgtca tgttcactgc tctccaactg catagacagt gtgtcgtttg caagcaagct 300 gatgaagaat tccagatcct ggcaaactcc tggcgatact ccagtgcatt caccaacagg 360 atattttttg ccatggtgga ttttgatgaa ggctctgatg tntttcanat gctaaacatg 420 aattcagctc caactttcat caactttcct gcaaaaggga aacccaaacn gggtgataca 480 tntganttac aggtgcgggg tttttcanct gancaaattg cccggtggat cgccgacaga 540 aactgatgtc catattagag tgattagacc cccaaattat gctngtccct tatnttggga 600 ttgcttttgg ctgttattgg gtggacttgt ntttcttcca aaaaattaat atggaatttc 660 tcctttaata aaactgggat nggctttcgc cnctttgtgt tttgtgcntg ctatnaaatc 720 t 721 <210> 538 <211> 746 <212> DNA <213> Homo sapiens <400> 538 acactacctt cccgaagttg aaggcaagcg gtgattgttt gtagacggcg ctttgtcatg 60 ggacctgtgc ggttgggaat attgcttttc ctttttttgg ccgtgcacga ggcttgggct 120 gggatgttga aggaggagga cgatgacaca gaacgcttgc ccagcaaatg cgaagtgtgt 180 aagctgctga gcacagagct acaggcggaa ctgagtcgca ccggtcgatc tcgagaggtg 240 ctggagctgg ggcaggtgct ggatacaggc aagaggaaga gacacgtgcc ttacagcgtt 300 tcagagacaa ggctggaaga ggccttagag aatttatgtg agcggatcct ggactatagt 360 gttcacgctg agcgcaaggg ctcactgaga tatgccaagg gtcagagtca gaccatggca 420 acactgaaag gcctagtgca gaagggggtg aaggtggatc tggggatccc tctggagctt 480 tgggatgagc ccagcgtgga ggtcacatac ctcaagaagc agtgtgagac catgttggag 540 gagtttgaag acattgtggg agactggtac ttccaccatc aggagcagcc cctacaaaat 600 tttctctgtg aaggtcatgt gctcccagct gctgaaactg catgtctaca ggaaacttgg 660 actggaaagg agatcacaga tggggaagag aaaacagaag gggaggaaga gcaggangag 720 gaaggaggaa gangaggaag angaaa 746 <210> 539 <211> 740 <212> DNA <213> Homo sapiens <400> 539 tcttccgggc gccgcagctt cctgccaagc accgcgcagc cgcctccgcc gcaggatccc 60 ccggtgcagg cctccgtgct ggtgcggatc ctggagctca gccgcgcgcg ccctgcccga 120 tcctgtgccg acccaccgca ctatgcgcgc cgtgccgctg cccgccccgc tcctgccgct 180 gctgctgctc gcgctcctgg ccgctcccac cgcccgcgcc agcagagccg agtccgtctc 240 cgcgccgcgg cccgaacccg agcgcgagtc gcggccaccg cccggcccgg ggcccgggaa 300 caccacccgg tttgggtctg gggcggcggg cggcagcggc agctccaaca gcagcggcga 360 cgccttggtg acccgcattt ccatcctcct ccgcgaccta cccaccctca aggcagccgt 420 gatcgtggcg ttcgccttta ccaccctcct catcgcctgc ctgctgctgc gcgtcttcag 480 gtcgggaaag aggttaaaga agacacgcaa gtatgatatc atcaccactc cagcagagcg 540 agtggaaatg gcgccactaa atgaagagga tgatgaagat gaggactcca cagtattcga 600 catcaaatac aggtaaaacc tgtttccagc ctggtggcat cctgtggaaa agttggncaa 660 gcttgcaacc tggggtgtga aaggacttgg acctggaagc ccttcttgcg ttcggangtg 720 tttgaaacca aaacgnaacg 740 <210> 540 <211> 692 <212> DNA <213> Homo sapiens <400> 540 acgggtgctg cgcctagctg cgcaccatgg ccgggttgct ggcgttgctg ggtccggcag 60 gcagggtggg cgcccgggtc cggcctcgcg ccacctggct cctgggcgcc accgccccct 120 gcgccccgcc gcccctggcc ctggccctgc tcccgcccag gctagacgcc cggctgctcc 180 gcacggcgcg cggggactgc cgcggccacc aggaccccag ccaggccacg gggacaacag 240 gcagcagcgt cagctgcaca gaggagaaaa agcaaagcaa gtcacagcaa ctgaaaaaga 300 tttttcaaga gtatggcact gttggcgtgt cattgcacat tggaatctca ttaatttcct 360 tgggcatatt ttacatggtt gtgtcaagtg gtgtggacat gcctgcaatc ctgctgaaac 420 tcggatttaa agagtccctg gtacagtcaa aaatggcagc aggcacaagt accttcgtgg 480 tggcctatgc aatccacaag ctgtttgcgc cagtgagaat cagcattacg ctagtctctg 540 tgcccttgat tgtcagatat tttcgaaaag tgggattttt taaacctcca gctgcaaaac 600 cttaatgaac tcttcagtcg tacacactga aaacctattt cttctaaatt acatgatttg 660 gattggnttt angggtttta agggttnagg gg 692 <210> 541 <211> 381 <212> DNA <213> Homo sapiens <400> 541 gtgatcaaag atgtttattt aaatgcagat tttacaacct caacttgtcc ctttacaaca 60 ggtcttccca gagcttttaa tgtgcagaca ggcatgtgaa cctctgataa agagagggaa 120 aatggagagg catcttcctc tgacttaata caaccctttt tacttttggt agaaaatcat 180 aaggcatgag tgtttaagga gcacactttg ggaaatgtgg ttctactanc cttactaggc 240 aaatatgctt ctaatatgta taactaacac atgtnaagca ctaattatat taataatgcc 300 atgagtcctt ttttcttttt ctgtctactt ctatgatagt ttaataccat gctttctttt 360 attatcacta aaaagatgga c 381 <210> 542 <211> 385 <212> DNA <213> Homo sapiens <400> 542 agatatgtaa aatctttatt gtttcatcat caaaagtttt ctttccatag aaagaatggt 60 aatgttgtat cagtgcatat tctatggaaa attcatatct caagtaacta gcctagaaat 120 cagagacagc actatgtcna gctagtatac aaggtcaaag acacaatgct gccaatgcaa 180 ttagtatata gaaataatac gcagctgtta gaaaaagtct gtggccaagt ggataaaaca 240 gtaacagtgc actgcactga catccanaac agaaaatngg gaaggaccag anaatgcnct 300 tcctgcaaaa aaaaagtcca gtagatcnca agcacaaaga gttcccaact gtctcaccag 360 ctctctaact catgtgtncc tgcac 385 <210> 543 <211> 512 <212> DNA <213> Homo sapiens <400> 543 gatttctgaa acattctttg tttaatcata taattatttt catctnccag tcatcataaa 60 taatccactt tatgacttaa ccaatccttt tgaaaaaatt tggtatttag cacaaacact 120 gaacattagc tagaggtgtg ttaattttta acagaatagg gaaaaatttt aaaaaaccca 180 caaaaatttt aatactaaga aaaaacatga aaataccaac attattaccc attaaaaaat 240 ctaattttgt tacaaccatt aaaaaaaatc ccaggtggga aaaatgagta aacataaata 300 taatctaatg tntttctttc ataaatacat ttagacaaaa caaatgcata aaacagatag 360 ctttacagtg ttntaaacat aacaaaatat tttaagctct gaataattaa atcccaataa 420 gcatgnaatt aaaaataaat ttggatttna tttttngtnc tttatgaaaa aatttgccca 480 aggaatttgt gtttaaaaaa aanaaattag gc 512 <210> 544 <211> 408 <212> DNA <213> Homo sapiens <400> 544 aggacaacgt ttgtttgttt ttattttaaa aagtcaccat attaataaaa atgctacaaa 60 acccaaaata aatatcttca agttacaaaa gcaaaacagg tctanaaaag ttggctgtaa 120 aaaggcaaca gagaggacag acccaaaaga taaatgtctg cttgcttggg tggggctggt 180 gctcaaggan ggacagttgt tggccctctc ccccgaccat gccttaaaan catctccgcc 240 aggccagtga atcaggcctg ggtgataacg gaaaaagttc catgcctgca ggcatcgttc 300 tgccatcact caccganctt cctggtctgt gttccccttc ccagcctcac tgttacccgt 360 aaaaatgang aacccagccg ggtgaantaa gaanagcttg gcttcana 408 <210> 545 <211> 260 <212> DNA <213> Homo sapiens <400> 545 ggtgtacatc tgatttactg aattttaaag tctgggatgt tagtggggaa aaggcgaggt 60 gagcattgcg tgacgccgag gactangcgg ggcggggact gcacctggct aggcaccccc 120 accctgggca acttgcccac ggaccccagg gcagtgagta ttgacaggag gtancccggg 180 gtgagacctc tcacagcaag aaaatggtgt ggttgctggg gcctccctgn anagtgtcnt 240 ccctgcggcc cctgggaant 260 <210> 546 <211> 496 <212> DNA <213> Homo sapiens <400> 546 gagatagagt ctcactctgt cacccaggcg ggagtgcagt agcacgacct cagctcactg 60 caaccttcat ctcccgggtt caagtgattc tcctgcctca gcctcccaag tagctgggat 120 tacaggcatg cgccatcaca cccagctaat tttcgtattt ttagtanana tggggtttca 180 ccatgttggc cagattggtc ttgaactcct gacctcaagt gatacaccca cctcagcctc 240 ccaaagggct gggattacag gtgtgagcca ccgtgcccgg cacaaccttt ctttgttatg 300 aacactgtgt ctgctgtgag atatgctgca gggccgccct aatcacagaa agcaatggat 360 agaaacatct gacttttgca tagaaaaaaa aaaaagcnaa atgtgggaaa nangatccca 420 ctantcttgc tgcactgtca ctgggaaatc actcanggga acatctcttt ccttcccaaa 480 acgctggaag aaatcc 496 <210> 547 <211> 248 <212> DNA <213> Homo sapiens <400> 547 ctcaatcaac aagtgtttat tgatcaccta ctgtgtgcct ggcactgtta cagatagtct 60 gggggataca gagaggtcta ggatatggcc cccacccacc gaagggttta caatatactt 120 gtgagatcgg acacacacac acaaataacg atcaatcaaa aattgtgaat gctaagcatc 180 aagaagcaat ttatacattg agggttgggg ganggagggg tnnganaggg atggggtgat 240 caccanaa 248 <210> 548 <211> 275 <212> DNA <213> Homo sapiens <400> 548 ccaaaaacag cattttcttt gtgcaaataa aaacgtgtgt atcaagtatg atgttccccc 60 aacgtggaca cactcagttc ctcacaaagc caagcccgct gcagctgcca catccctggg 120 cttacggtgc agcaggtgct tttttcaaga caggaatcaa aatgttagga acacggcana 180 aaggggacac ctggagacca aacgcangat gaggaatctg canaggtcca gggaatccag 240 aacagtaata ccctancang ggcatggggc gtgaa 275 <210> 549 <211> 532 <212> DNA <213> Homo sapiens <400> 549 aaactcagta attcctttat tttgatttta aattaatcac aaccatcgaa gtggtaagaa 60 acagctgaca ggtgtactta aaaatactga attgacagct acattgaatg cagggtttcc 120 cagggtagtt cttattttgt cacttactcc aattacattc aaggtcgtta tgcctcatct 180 ttttcctgag ctgtggcagc tctaactggg gcacccanag agatacatac caggtaatct 240 ccacttctac ttttctggta gcttggccct ggcaaaatga gccccacaat ctanaaagta 300 ggatgctaaa caaagttgaa tcaacatatc tttttagaaa atatcaggtt agagaatact 360 cctgangacc tgtttctaac caganttgac aaatgtgaaa aatgcatcac tanacacagt 420 ccttgttaaa cacacccgga actgcaattc aagaaaatgg gttctngggc cgncctcccc 480 ngttacccaa aacctttttc ccaaaaccac ttctgaatnc ccccttnttg gg 532 <210> 550 <211> 280 <212> DNA <213> Homo sapiens <400> 550 gagctgtcaa gagaacttta ttcattggaa actgggccgg agaccctcac gaagctgcaa 60 gcccctgggc cctgggccct tctgtatttg aaccctagtg aaatgtgcac agtctgccct 120 ctccatgcca ggggagagac agagaggaat gccntttttc tgtgtgatgt gggagtgaca 180 ggggaaagan cagaaatccg gttatccctc ctganactcc cnctgagctg gggtgccaca 240 gggcacgtgg ccccaaantc aggtncaaat gcatcccccc 280 <210> 551 <211> 587 <212> DNA <213> Homo sapiens <400> 551 aacacaaaat ttgaattaac tttatttccc ctacagtcaa caacttctct gcattgaatt 60 ttaaagcaac aaagtaaaat aaaatccccc aaatgacaag gtatcagaaa tccaaacttc 120 gttacactct atttgtgaaa atgttcagcc attttattgt tctgtaaagg aaccatcatc 180 tgggtcaaaa atgaattcta taaatcaaag aatattctac accttggaaa aaaaaatcag 240 cagtaacatt ctcactgaat attgtaaatt acatttttct tcataaaagg tacatactat 300 tctgcacttt tccaccaaaa gcagtggtgt gttatgcttg ttatataaaa aaaagttata 360 tcctgtggca ggaaaaaccc tttctctttc acttttacta aacaactgga gaaaatgttc 420 aagtctgtat aaagttgcct ataagctggg aaagtgaact gttcaatctc catttacatt 480 ttagtgcatt tttgacaatt gtcccttttt taacaaaagt tagaaaatgc ttttnccctt 540 aaaaaatgtt tccccccaat gcttnagggg attaaaaaat ttggaaa 587 <210> 552 <211> 437 <212> DNA <213> Homo sapiens <400> 552 ccaatcaaat ttctttttaa tgaaaactaa tttttaaggg caanatacca cagcaaaaaa 60 aaaacgtctt gcaaaaaaaa acttcatggt ttacaacnat caaatgtatg ggctatttgc 120 ctgattggtg gcctgnactc ancaanaaat tcctttgcag canaggttgg ccacacatct 180 ggggggtgca acaccactga aaaaacagct ttctaagcat tantgtnagg caaaaagcaa 240 antgcctaaa cttggccatt tccaccaana aaaaaagttt catagcaacc ttccttcacc 300 anaaaggctt actttatgat atgctaacag aacanaaaag caggttggga caanatacan 360 antttgttgc atttanctat gaccttctct ccctctgtgg attttggcag ggtngggaaa 420 agcaggaaaa agccntn 437 <210> 553 <211> 588 <212> DNA <213> Homo sapiens <400> 553 ggaatcatca ttaactttat ttgtcactct tgatanacat tggtccactc caacataaaa 60 agtagaattc acccacttcc acttaatatt ctatagaatg aagttgtacc acaaaccata 120 gtaacttaca cagggggaaa agttactgaa ataaaaatgt tttatattca tgcctcaaaa 180 tgtccctcag ggatttttgt gtgtataatg aaaagcatct atatactcca caaggctagt 240 ttcttcttag atcaatgtag tatttttagt atccatatta gcccatgtag gtcaacaaac 300 ttgcagaaga gggttaaaaa acagttgtcc tctgttactc agatacagtt ccaaaactaa 360 gcgattatat aagcacatcc atattttagg gctactctaa gttaaaaacc tttnctcttg 420 tttcagagtt atttacatca aattaagaca tttacaaatt gttcatagta tacaatagcc 480 caaatatgaa tttccaccta tgctgtgtaa anaattnaac catccgtaat ttgtctaata 540 aatccatgca ctttttccct aaacaaacta tcccaaantt ttactttc 588 <210> 554 <211> 594 <212> DNA <213> Homo sapiens <400> 554 gaggttgggg agagataacg ctgtaaactt ttatttttca ggaaatctgg aaacctacag 60 tctccatgcc tgctcagcca agaaggagct cactgtgggc accagagaca gggacccaat 120 gtggagacct gtgagcctgt gtccggccct gaactctcaa gcacagggca ggcttcctga 180 gcattgaaga gaatatgtgg gagaacaaaa cagaaactga aagaatatgc aaggtgtctt 240 tcttggatgt tattccatga tagatagtag gggcaggagt gagagaggct gactaggtct 300 ggacatggag gctggaagag tcagggtgtg attcggagag gcgcatgaga aggaaggtgg 360 attttaaggc tggaaatctg agggtcagtg gtccaagtca ctcagagaca gaatcacagc 420 atagcccttg ctgatggcaa acaaaggagg acaagaggac tggaaagaat tctgctagca 480 ggcaggagct antaaggatg aatttgtanc aaaattacca agtggaaagg atgattttgg 540 gcatttttcc ggtcttcaga aaacnggaga tacttnaagg ctnnaaatgg ggct 594 <210> 555 <211> 585 <212> DNA <213> Homo sapiens <400> 555 cttatgaaca ctatgtattt acacgtactc tttcatggaa ggaaaactga gatggggaag 60 atctcagggc agagactcca tattgcaaca tggggatcat gcactcccca cagattcaga 120 taaacttgaa gaataagcag aaccacccca aggactcagg gcacatttgc ccccaaccac 180 ctccagggct cttccttccg gccaggctcc aaccagaaag caaagtcata gctatgccct 240 gtgccccatc cccaaaacta atgggcccaa gatagggggc cagggatgaa ggtttacagg 300 agttcagatg ttagggggaa gccctgattt gctgcagaaa gcagttctga tttctcatgg 360 gaatcaggaa tcaggcaaag gtctggcccc aagcccatcc aggctcagag agaacagata 420 ctaaaatcca agtaatcact catactcaaa gagaactcag aggctgggat ggtcttccag 480 gcccagttga cccccagcat ctcagtggtc actccgttcc agtgatcact tatacactta 540 gtgggcattt gcccagctnt aaatgggatg ttttcatcac atggg 585 <210> 556 <211> 573 <212> DNA <213> Homo sapiens <400> 556 aaacagagaa caaagggatt cactcagaga tcagaatacg aagcttcctc tcagcatcat 60 gggaggagat aaaataattc attctatggt ctttgttcca ttaagacttg gtgctttctt 120 cagtaacagt atgtgaaatg tggctgactt tgagtccccc actgtgtaag tggaattatt 180 tttcactgca gcatttctga gtctttttct tgttccttac tctgaactgt aaaattaagt 240 tcataaaggc atttggcaag ggtggaggaa gcttccatgt tactaatggc tagcactgat 300 aagttatttt catgtctctt taacaatctg cgaccacatt ctgaatattt accaatattt 360 tttaatatta aggcagctgt tagtcggatg tgtttagtta ttggtccctc tttttcatct 420 gtaaaatctc gaaagacaag gtttcttgat cctctcctca gagccataag tgcagcactg 480 ggatgattca caatggnctt ttgtgctcta agagttgaan cttggngccc ctacagtngc 540 tgntttggaa aaagacttnt gacttcctgc gng 573 <210> 557 <211> 591 <212> DNA <213> Homo sapiens <400> 557 ccaatgccaa aaactggtga tttatagaaa tcaccctggt ttattttttt caacaaagga 60 aaaaaaaaac atggttcaat aattcagcat ttgggactct ggcaagtact gtctgcattg 120 ttcaaaataa gtgttcctgg ctgtgagctc tgcaacacat actgatggcc caggaacctt 180 cttccatggt tctaataaaa caaaggaccc acacatggag gttacgtgag tcaacaaaag 240 atgctctatc acaatgtgcg taaaaagcaa gtctttgaaa aatatccaga tctctaaagg 300 aatacaaaca ctcctatttg gttttgtttt tgttcatctt cagtattata ttttagttgt 360 tgaggaaaat tttttttact gtaaggaagg agttatatga ctttataagt gggaaccaac 420 aggctgccgg ctaatacata cgctttccct ccaagcaagt agctttttcc ccccgaaagc 480 ctctttcatg atttcaatat gggtcaaaaa agtaaangaa aatggatttc aaggtnttca 540 attcctatta aaaaatgggt atcaaaaggt aatngaggga cctaatttnt t 591 <210> 558 <211> 531 <212> DNA <213> Homo sapiens <400> 558 aaaacatcaa gcaatgntta ttgngcaatt ccaatcatta tttgcagaat cttggtttan 60 agtcagtctt tatagccatt tcaactgctt ggtttaaaca aaaagcaaca atctggttat 120 ctacctataa atttcatggt ntttctttaa acactgaagt actaaaagcn ctgatgattt 180 gtattataat ttttaaaata tttaaaacct acacagattt catagatcat tccttttata 240 aaataatcaa aataatttga ttatctggaa aaaaaaattc ttgaaacaga gccctttcca 300 ggtatcttca atctctgtaa aaccccaaac cccaaacaga gtanatgatg aaataaggat 360 ttctcagttg cccaagactg tctgaaattt aaggttgata aatggactgg cgtttttcat 420 gtttcctggg aattcagagc ttacangtgg catcagaacc tcagatnntc tnggatggnt 480 ttacatgggg tttactttgn atttggtcat tttcatttgc tttntttcca a 531 <210> 559 <211> 457 <212> DNA <213> Homo sapiens <400> 559 gcccaaattt atttttattt tgcacacata ggaaacagga tcctatcagn nngagaacaa 60 aaaagagaaa cgagccaatt gttgcagagg aaaagcatgc acagatctgc ttcaagttta 120 ctctgaacca cggacgctcc gggaattcta cacaccagga gctgtctcac tccaggaagt 180 gggcacaacc caccatccac acaatggaaa caagaatggc caggaaatgt caccgaagtg 240 ggacttccat atgcaggatc agcgttcaca gtagcacaat tctaaccaag ttcaagggaa 300 aacaaactct gtctcacaca aacatgggaa tacaaaattg ttgagcccta gccatcactg 360 nctcttacnt aattgctatc aaaaagacaa acngaaattt tagtnacggg acttttgggn 420 tgcctattta agcttgancc cgattcnagg gggcaac 457 <210> 560 <211> 554 <212> DNA <213> Homo sapiens <400> 560 aaatgagcaa gtttgagagt ctgcagtttg gactaccatg agaattgata ggaaggtggg 60 agtcccaggc aatcccaggt cctgtagcag cagctggtgg ggttcccact ccatgccgtg 120 cagagcctga actcaggatg acacctgcac ctgctctctg gctgggctct ggcacaggaa 180 gccctcagca aacacccccg gcacagccat gccatagcca gacaacagct cgctgtacca 240 caccatcatg ggagacagca gttattctga gcatctcact gctgaagaaa ccaaggctca 300 gagaggacca tgcatgcaca aggtcccaca gggacccaag aatccaccaa gtgtcaagac 360 aacttgccca tgctcttcac ggagcacctt ggaaccctcc ccgacaggca ccgctggctc 420 tctgacgtgg cctgcaagtg cgtggagccc cttcctcctc ggccattccc agtttagatt 480 cccaggggaa gcatcagatg gnccttttcc tgctggcagc anaacagacg gaaccagcca 540 gaanccaagg cagt 554 <210> 561 <211> 541 <212> DNA <213> Homo sapiens <400> 561 aatgaagtgg ttagaaaggt ttattttgtg cttaggatat ttttctaagg catcacaagt 60 tacacatcca aactcttcaa tggtacaata ttttaaattc taaaggagag ggctttaaag 120 aaaacttgta tattacgata ctgtaaatct aatggattca cacagcaaca gagcctagaa 180 agaaggggac attacagaaa ttgtctacta cgcaatggtc agttgattca ttgtatttat 240 gattttcccc cttcttttaa ggtgaaaact atgtatccta gctctttaag gagtaaaaat 300 acactaaaat gttccatcct actgactttt acctgtgaaa tcccacacaa tattaccagt 360 caggaaagaa cacaggataa tatgaagttt gncttttaaa aaatataaaa atgntattat 420 tttaaaacat caagcattac cggactgnaa aatccattaa agaactttct ggatatgaag 480 gccaaaattc ctttaagacc ttttccagaa gangcttttt nctgagttna atgcaacntt 540 t 541 <210> 562 <211> 541 <212> DNA <213> Homo sapiens <400> 562 ctcatacaaa cattatgtat ctttatttaa atttgcaaat gaaaacaaca catatttcat 60 gttagtttta ataaaanatt ccctatcctc tgccccagta aaacctaacc aagccagcct 120 gacaggttat atcaatacag gganctggag tggganccaa gggtggtgtt anataggggt 180 ggggtacana tcaagggggc ctgggaaact cagtgactgg aagtctctgc ccctcactct 240 tggtgantag ctaatttcag cagctggctt cataaggaag aatcaggggt gggtggaagc 300 tcctcccaat tccanatcca cttcctcttc tccttctgtc tcctgggaca cttangtctt 360 actganatgg ttttcccaca ntaaaaaaaa gtgggggcan aatactaagg gtcangaatg 420 tgactctttc ccatgactca ggcctctgtg ctaaaagtga cccttataga aaggaaaaac 480 cccaatcctt taaccaatna ntggtggggg tctcntncca aaaaaccnct ttaatctggg 540 c 541 <210> 563 <211> 251 <212> DNA <213> Homo sapiens <400> 563 aataaagcan aaatgtattt attaggcacc cttgttcctc acagagggag caagatccag 60 gcctgagcgc ctgggaagtc tcttgaggtt gcaggaatct ccananaaac ataggcgctg 120 cccagccacc accccganaa cactatttgg ctggagtgtg accgccgang tgatcctggc 180 aggaggctgg ggttggctcc tccactccnc aaacactgan gantgggtgg ggacacccnt 240 gacacccacc c 251 <210> 564 <211> 249 <212> DNA <213> Homo sapiens <400> 564 atcaatactt tggttttatt ttaaaacagt gaaaagaaaa ataaatatct gaagaataag 60 aatacanggc tgggtgcagt ggctcatgcc tgcaatccca gcactttggg aggcggaggc 120 angtggaccg cttgagccca cgagttcgag accagcctgg gcnacacagt gagacccccc 180 tctttacaaa aaatacaaaa attanccacg tgtggtggtg cacctgtant cttgagtggg 240 ggcgccaca 249 <210> 565 <211> 504 <212> DNA <213> Homo sapiens <400> 565 cagtgtcagg actagtatat tttattttca gatgcaagca gcaactttgg catttcttat 60 cacaaaaaaa ctatatgaga aagctggcaa gcccagtgaa cttcctggcc gganangttt 120 ttccattaaa ggtggcaagg tttgatcatc caccatcttt agagttagac cattgagttg 180 gacagatttg gaaagtaatc catgaggtcc caaaggtctt aaaaggtatt tatccacttg 240 cttgttaaaa aaaggatagg gtaaccgcaa gtacttggtg acattatgga ggtttatggc 300 atacanagtt aaatctcctt ctttatacct tggattgtca gtgtttgtgc aatgaaagta 360 tactccaanc ttccttctct ttgaaccttg cacgcttgcc attaacacct tggtgccccc 420 aatttcttga acanaaaaaa tacccntaat ccgttaanga tccaaatttt ccccnctaaa 480 ttggtngttt cccgctccca aaaa 504 <210> 566 <211> 536 <212> DNA <213> Homo sapiens <400> 566 gcctgtaatt taaactttat ttcatatcta ttgttaaatt acacaaaatc agtggaatgg 60 tttgtaaagc tacaccaatg gacagatgtt tacagttgaa atcatgggat ttacataatg 120 gcaaaaatgt atatgtatat ttataacatc ctctatatac aataatcagt atanacagag 180 aaaatgcact taatctttgc aaatcatgca caccacagca ataacacaaa atgttttttc 240 tgtaacaagc ttttccactg gctcaggctt catcctgctt tccaacaaaa cctatcagtt 300 ttaannagca aacattttca attaaaacta aagaaaattg aaataccata gtgatctact 360 aactatttta aaaacacaat tgtncacaaa atagttttac tctaaaacac tgtgacttca 420 aggtntggaa aaattccttt cagtttttag ctctcangat ttcaagactg caatactgtc 480 agacaaaaca aaactagaaa tactgatcca gccngantcc anaaaatctn ttttaa 536 <210> 567 <211> 571 <212> DNA <213> Homo sapiens <400> 567 gatcattgat agaactatgg ctccttaact cagaagggcc cttttttctc aaaacaacct 60 ctgcaagatg taaccttgac ttcccaggaa aatgaaaggt agttaacaat ttcccccatc 120 acctatgtna ctccctaaat aaataaaaat tacaggcagt tgctcctgga gattacatat 180 tatggtgttg atgacaatct tttagaanac gttaaacttt ttagtttgtc agatttaaaa 240 aatgaaacat tacagaaagt tcaggaacaa cacacttaag ttgcatgaac atccatgtca 300 gantctggga ngaaaggggg caacagtgtt gtnaataaga agctcgtana tttttctcat 360 cttatgaact tgttttcagt aagatgttct ctttgttctg acacctctcg ccaactccaa 420 tgcccnaaga tcaaggaaca gatcaggatg tcttgcttcc tttaatccca tggaaccgtn 480 cagaaaaatg acccnaatgc tgatctctcc cctgatggtn ccancttnac tggcaaatct 540 cccatcccta ctccatttgg accttccaaa t 571 <210> 568 <211> 554 <212> DNA <213> Homo sapiens <400> 568 ggacaaaaca attttttttt aatctgtctt gtaaaatcct tacttccttt tgagtctctg 60 atggccacaa catttcattt ganatgtttg gcagtcacag cttcaggggt tatggttact 120 gattatctaa accccttagg tcagaatgaa caaacacagt tcatgtaaac ctggctgtta 180 ttggagtcct ctgaccaaga nataatagtg aanagtgtgg agagcctgaa tgcccatggt 240 ggaaatgctg gaaaaattaa aggtaagaaa taaaacatag cacaggagat tcagagggct 300 gggatgactt ctgagctgct ctctataccc aaggcccttt caatttctan ctgtgaaaaa 360 ttttncatgc actgtggtgc ctgatnttcc tgcaatttga caaaaataan tactttaccc 420 aanaaaaagg atgccaggct nctactttac cctttgggga tgcncaggaa ccaaggcncc 480 tgcttggctt ccatttcnca gggcccgcca ccttttccct ggaangttct aattangaat 540 tgggaatggn cncc 554 <210> 569 <211> 505 <212> DNA <213> Homo sapiens <400> 569 gcaatgaaaa ccctttaatg ttgggctttc tttaaataaa acagaaaggt tgcagctttc 60 ccatggtggc tgtaaggcaa gaacagcagt gagggcgggc cgtgttctat cgggcagtgc 120 tgcagccctt gactctggct caaggtgggc ttcctggagg cagcggcaag gaggcagttc 180 tggatgtgca ggcacagatg taggggaaca ggcaagcggg cacagggccc tgagctgaca 240 agcagtgacc cctgcaccca gctagatggg gcaccccctc tctgggagct gagggcatca 300 gctggagcct caggctggga ccagccccaa ctttgccttg gtgactctgg gccattccag 360 gcctcagttt ccccagctgt aaggtgaggc attaggcagg aaggggtggc cccagccagt 420 gtcctagtaa cctggngtct ccattaggga gacctgagaa gctgccanga naagctntgc 480 tacccaangn aaggcccggc caana 505 <210> 570 <211> 588 <212> DNA <213> Homo sapiens <400> 570 acatacacac acatttatat atataatgga aaaacatata tatagttgcc cctccacatc 60 cgtgggctct gcatccacag attcaacaat ggatgggagg aaggtgggga ggaagggaaa 120 aagaaagaga accagggtgc aaatcaaata gaacaatgat aaggccaggt ggctgccagt 180 ttgtgactct tgctttatgt caacttctta gtttctgtct tttcccagca attcaagatg 240 tgtttaagaa cttaattcaa ggtgtacttg gaagtagatc aaatgcaggt agaatttcca 300 ttgccttgcc acttctttaa atctaaccat acagttttta ttgagcacct aacatacaca 360 cacagtctct cattacatca cactaaaaat gaaatatatt aataattagt tcatgaaaca 420 gagagatata acttccataa tggtcaaaaa tgactctgag atcttactta cattttanct 480 gtttaaaaaa aannaatcag atttaaggag aaatactgtt tactggaaca cttaacatnt 540 ataatncttn taaatgcnaa aaggttatgg gaaagttcct aacattgn 588 <210> 571 <211> 578 <212> DNA <213> Homo sapiens <400> 571 gtgttttttt tttttttatt aataccacat caatttgaaa ttttacagga accaagattc 60 aagctcctta ggtgctactg tatttttatg ttgcacgcac agacacgtac acacagtttc 120 attagtaatt tttcatctat aggtttttct taaaaaaaaa aaaaatcctg tgtggcacaa 180 agatctcttc aattatctaa acacagcagc aacaaaagaa aagaactgga tgtggcactt 240 ccactgcana aggtcctttg gaggggaagc ccaaaaagac aatcactgac ttcctgggag 300 ggcagaggat gaggatggag aatgcacttc ctactaggac atgaaaccag ttaaaacact 360 caaagggggc taagaaaata agatggagta aggcaagggt accttttacc catccaaatt 420 cctaactaat ttttccaaga cacgtagaca atttccttcc tactttttgc acttgccgta 480 ctttgggacc atcaaatatc ataagccctt acttttaact cgnccgtgca tattnccttn 540 tggaaggatc atgactttga gtgganaanc ctgaagga 578 <210> 572 <211> 521 <212> DNA <213> Homo sapiens <400> 572 cacagcaaac ggagtggagg cctgtatttc acacctgctc actcactcca tggcttanaa 60 aagaacacgt ccaccgcgga ggccgcaatg cccacctaga gcaggtcgta naagtagtcc 120 aggccctggc ccagctccca gatagagacc ccaacgccca gctcccgggc cagctccagc 180 cgcacctgca gggacttcag ggttgggtag aagacgacgt gcctcccact gcggctcttc 240 ttgtactcga anaagtgctc tgaggcctgg ctgtcccaca ccatccgggg cctgtggtcc 300 ttcagtgtct ggatgtacct ggccccgaca acaggctcac gggcatcctt ggaggtcgcg 360 tagtccatac catagaagtt gagccccagg aggattttgc ttcgccactt ggacttcggg 420 tccaggacct ggacgcaggc tcgaacccag gacaggggtg cattagggcc aggctgatgc 480 cctgtaaant aatccnangg catgangntn aaaccntttc a 521 <210> 573 <211> 539 <212> DNA <213> Homo sapiens <400> 573 gaatgaaaag ggcttttact ttctttttaa aacaagtgat ttttaagggt ttgtagaaaa 60 agcaaagaaa agcataattc tcctcttact tcaagctagt gtccgatgag aaagtaccag 120 gctaacctct gaagaatcct accccaacac cttcttcttt cttctgctgg gatgaacatc 180 taggggtaag atatgactgc tctctaccat ctggggactt ctcttcttta tattgttgca 240 ttcctcaatc tttgcataag gaagagaatg gctaattcct ctaggtgcca aggaagagct 300 tccctcttcc tacagcctcg catgtttctt ttcccactgg ttgccaggaa gcttggagat 360 atggtgacga ctattcaggc acacatctct tccttgggtc ctaccacagt catctcctcc 420 aatatgcagt gatgttgaca ggcttggaga tggtgactag ggagttctga actangnacc 480 tcaaatctat caagtccnca gttaccngga cttgancatt cttagggttc ngnacctcc 539 <210> 574 <211> 596 <212> DNA <213> Homo sapiens <400> 574 cttttttcag aacattcacc tttaattctg ttacaggttc cagtatttgc gctggcccta 60 gtcagctgtg ggtaagagtc acccatgggc aagagtgggg aggggactgc tcccccatga 120 accacatcct cagtgttggc caaataccag cgtgttgggt aggcttcctg tgtccaccag 180 gcctggccat gtcctgcaca gtatagcttg gacctctggg cctgaaccag ggtgagcatc 240 aaggccccca tttctcctca ccacggggtc gcttgtcagc tccaggagcc agtctggccc 300 cactgagaac ttttcagtcg agggcctgat gagtcttggg aatgcgcttc tgcaagaggg 360 cccaggcttt ctccacctgg cgttgggtga tatgcggctc ccacaaggtg ctgagcacca 420 cgtggctctg ttccacaagc tgctgcccgc tcatctggct ctgcagcccg gctttgagcc 480 cgcggcttca ctgaggccat ccctcttcac aatgcgtctt acagcctcag tctctgggat 540 gacaagcagt ccacacctta tggaccaagg ttttggcaac ccgntttagc nacaaa 596 <210> 575 <211> 430 <212> DNA <213> Homo sapiens <400> 575 caaaagggag cagaggaaca aacaaggagg aaagggcgcc acacacagcc cagaccaggc 60 aggagcggcc cagccgccgg aagagacgtt ccttgcaagg cagggcccct gctggacagc 120 acgccccctg ggcgacaggg tcagggaccc caggactgca cagctgcaga cttgctggga 180 acctgggaca ggtgacacgc ccactctcgc ctgtggccca gggccttcca cctctgcatc 240 cagccatgca cccaccattt ccccacaggg tacaggggca gccttccttg atccacagcc 300 aacccttctc ctgctgtctc tggctgtcag tgagacccct ctggaaaggg cagaagcagg 360 caagccaggc agaagggggc ccggggtccc actacctggg taggaatgag cagagggcgg 420 gcannnnnnn 430 <210> 576 <211> 586 <212> DNA <213> Homo sapiens <400> 576 gagatttcaa tacaatctat attatctcat atatagattt cttcctcact ttatttgctc 60 acttctgtca cgcatttaaa atgtcacaga gaccaaaata gagtggcttt ctggtggaac 120 tcatggcagt catacaacaa gatacaaaac taggagactc tgtcttctca tacatcatac 180 aattaatttt tcaagtattc tttatgtaca aagagctact ctacctggaa agaaaattta 240 aaaaaaaaaa gacaaggtag gttatgcatc ctaaggagga ggaggggatg gagcggtcgg 300 gcacatgttc ccgtccccac gaccccacgg accgctgatt ccctgccact gagctccccc 360 caccctccac gcaaacagca acgctgggca ggcgaaaacc aagggagtgg gaatcagcag 420 cactttggcc tggagggaga agggaacccc cggtggaaag acagcttggt gaaagccaga 480 tggcgggcan ggccaaggct tggncttaac ctgngttgna ccaccttncc ggcagnttgg 540 nccaactggt tcggcccccc aaaatggagg gggaaactgg ccttgg 586 <210> 577 <211> 535 <212> DNA <213> Homo sapiens <400> 577 aaaaaaaacc atgaatcatt tattctttgg ttgtctacac agacacttaa gtactgtatc 60 gctgttatgc agcggcctgt ggaggcccct gggggtggct gggcctgtgt cctgagccct 120 cagccagatc cagggggtgc ggtgtctggt catgtccact ccaagagcag tagcaccatg 180 tanaaggctg tgagcagggt cccctcggct gagtggcaga tgtaggctca ctgctctgca 240 gccccgaggg gctggccagc tcanagtgca gaanagttcc tctccatggg tctagtcacc 300 catccgtctg acctggacgc tgtcatagct catccttggg cttcgattca ctgcctgaga 360 gagactcttg tgcaggttcg ggggggccct gctgggcatc caagggctgc tnctgggana 420 agtccatctc ttctgggctg aaaacatttt accangtcat ntggctgcac cctgtnccgc 480 tccttgtgtc aaggtccagg gtgaacccan ggcnatgnac aacgctngcc cctgg 535 <210> 578 <211> 607 <212> DNA <213> Homo sapiens <400> 578 acacattaaa aactttattg taagtatcaa catctaaatt tgcatcaatt tgatacatcg 60 ttgctcattt tgcagaacat aacagttgca cattgcaaga gtcaacttgc ttcgggtctt 120 ttcatgctca tggcggtcca cccctgcctt ccctctccct gacctgcatc ctgtcctcca 180 cagtctgccc tgcctcctgt cgccacaggt tgaagaccca agccctgagg agaacctgct 240 gccanggggc tggctggctg cganccanga nggccaggca gttagccctg ccacanggag 300 gggcaggcaa gggatcgttt ctcctcttcc tgggctgagc ccgtgccagg ccagccacag 360 antgccctaa tcagcccatg tggctccagg aaacctgctg ttgttctact ccatcccatt 420 tcaccgcagc ctaattgcta actcccggat actcttaacc aaaattaacc caanttccat 480 gggaaaaatc caaaaccttg aaccattgca ttggttttcc ccattccttg tttctaaaat 540 ttttgaaaaa ggtnctgcca aatccnctgg ctgnaaaaat ttgggggaaa aatcacnncc 600 nntttcc 607 <210> 579 <211> 519 <212> DNA <213> Homo sapiens <400> 579 gcagcggtct gccttcatct tttaatggcc ggtgcggtac agttagtgga cagacggggg 60 atgggacaca gcaggggtga aacagggcag tcacagccgg ggccggggat ctggaagcgg 120 gggcggtcct ccccctggaa acaccgtctc tggaaggaca cccttaggat cccctgacct 180 cagggtgcca cccacacggg cctggtgttc tgggaggccc gggctggagt gacccccagc 240 ccctccctac gttccaggga cccttgggtc tgtcgagtcc cttgctggat gagggtcaag 300 acctaggtca agctgacttc aaccagggtg tgggggcccg gcttcgtaac ccccaaactt 360 acctnccctc ttctatccgg gccangaagg caatgggagg gctccctaat cangcacagc 420 cccctgacct gtggcatcgt gtgggtgttt tggggaggtc ctgactgccc anctgggatt 480 actgntgngg tttccaaagc ttatgcaaac cgangcggn 519 <210> 580 <211> 338 <212> DNA <213> Homo sapiens <400> 580 gtgattatac gttttattan actcgggang ggtatggcag ggcttcatca gtgttccttc 60 aaattaaaaa aaaaatacaa aagctacgta naaaacgtca gatcagacna ctaaactttc 120 ccgactcagg gccaagttct tcttgagcct gcgctctcgg gacgcctgcg aatcggtctc 180 cnaatacggg ggcggcgcgg gcgggtaata agcctcttcc tcctcctcct tgtggggtct 240 cctcctctcc tccganccct tcttcctcac agcctcctcc antatccgcc catcatangg 300 gangtccccg gacctggaac cnttgtcccc aaggtccc 338 <210> 581 <211> 480 <212> DNA <213> Homo sapiens <400> 581 catattcagc cagtgtttat taagagccta ctacacgcca gacactttac atgctgatca 60 catttactcc tcacaaccat cttgttaggg anacatcatc agtgccattt gaacaaatga 120 aaaactgagg ctcaganaga ttcaatacct tatccaaagc tctccagaca ataagtgcaa 180 aaacaaggat ttgaattcag gactgtttga ttccaaatct ggaactttct ggaacctctg 240 acacacacac acacacacac acacacacac acacacacag caccatgtcc tgagctgctg 300 cctcctggac tcccgccaga ctgcacctga cagacaaagc caactangag ggaggggagt 360 gagggganaa gtcccacagg tgaccaatgc ctggcccctt catgacanca ggggctaagg 420 ctgtcccccn nggactaaaa aaaagttttg aaaggcggga atttcccctt atnccccncc 480 <210> 582 <211> 377 <212> DNA <213> Homo sapiens <400> 582 cagacaattc agcctttatt ttagaaaata attctgtagc ttccactttc tttcatgaaa 60 ctgaggtcag gcaagaaaca aaaatccacc aagtcctctc catcctgcca tggcgtcctg 120 gcctgtgang acatggggcg cctgggaacg ggcggggaag ctgggcanca ctgggccaaa 180 agcgtcctgg tcactgctcc acctggtcac tgctccacct catgctgana ggancctgtg 240 tgtcaaaccc caggggaaaa agggacaggc agatcgaatt ctgtcttcta ccaagccagc 300 aggagcctcc taaancaaca gggagggcac tgattttcan aaagganggg tcagggcata 360 ntccctctct gangtaa 377 <210> 583 <211> 593 <212> DNA <213> Homo sapiens <400> 583 catgaaaaaa ataacaacaa aatgtattta aaaacagact tctccagttg gnattttgaa 60 tgaaattgct aacaactcca accctctata ttgtgtttct tttgctcctg gaatcctctt 120 ggagctttaa ttcttgaaac tcaggggggc agcaccagaa attaaatccc caaaggggaa 180 aagtattagt aaaccttttg gctggtcatt cttttccgaa atgcaaatgg gacaaattct 240 taagccctct tattcatttc atgatgatca ttagataaaa aaattaagcc taacttgcat 300 attgaaaata aaaacaaaaa cacacacaaa aaaaccttgc agataataaa tatcgcttat 360 tcacttattt taaacaaagt ccaattttat tcactctcaa tatccttgca gtccattgta 420 taccttctgc actgaccttg tttcagtaac tgtttgatan cttctctcgc tcctctgtta 480 ctggtccttt ggaaaatccc atcaaaantg attatcaaaa aacccttgat attgttgttn 540 tcnaattngg gaaccctccc cttcctccat actccctcct ggccggtgat tta 593 <210> 584 <211> 451 <212> DNA <213> Homo sapiens <400> 584 caaggataat ttttattgat gaaaaaaatc ttgcagatat gaaaagataa tttttttatt 60 cctatgacat tttctgtttt tacgattttc ttttcagcaa tgaaaacctc tgatgttctc 120 ttttaggaag gtagtttatc caacataagg atcccatcct tttccataaa tgaatcgatt 180 aatcatgtca aaagctctca gaggctggtc atagggtaaa atatgtcctc cacctcgaat 240 aattacctga tggaagtcac ccacttgccg gatgtaacca gccacttcac tgtcagattt 300 aaagatcttc caaacttttt tttctgcctt cttgtattcc tggggatcct ttccagtcca 360 tgcccatcaa ggaacgctct gtcagggcag ctgccacaan aatgtccant tgggcattgt 420 aaatcaaaac cttataatta ttcntgaatt c 451 <210> 585 <211> 359 <212> DNA <213> Homo sapiens <400> 585 cctgaataat tttttatttt gtgcagaagn aggatccaaa aatcccgggn tcaagtgatc 60 ctcccacttt ggtctcccaa tgtgctanaa ttacagccct gagccacggc cccatgcccc 120 gtttttacca gtgtatattt tctactggaa aatgagactt ttagggatga atgtggactt 180 gtctgttgaa acttgtaaat ttgcttaaaa aaaaaaaaaa atctccaagt cttcacaaaa 240 ttttatattc cccaaggctg ccccatcaca atgcctgtga ancttgactg gcaaacactg 300 aggcctgaan ctgggggcta caaggggtcn ctggctcacc cggtcccccc gtaatctgt 359 <210> 586 <211> 413 <212> DNA <213> Homo sapiens <400> 586 gaggtgacag caccgtttta ttcatgacaa tctgcaaaaa aacaggtgga tgggtcagaa 60 agtcactgca agcctacatt caggggctcc acccgcagcc aaagcccgcc ctcggcgcgc 120 atgatcaatt ccagcttccc gcggggctca ntgtggtctg gcaggaaccg gaagtgcagc 180 agcatcaacg ccaggaccac tttcatctcc gccatggcna acgcctgccc gatgcagttc 240 ctgggccctg cggagaaagg aataaaagcc agaagtgacc tccccttgct gttctctggg 300 tcaaagcgga aggggtcgta gacctgcagg tgagacaaag aaggtttgcc agtgggattt 360 cctatgtcca gcagccttgg agaganactt ntntntnttt tngggtnaag tta 413 <210> 587 <211> 479 <212> DNA <213> Homo sapiens <400> 587 cagtatttag taaaataaat gtatttttaa aatattttta ggaagctgca gaatggcgac 60 tgagtgcttc ttgataagtc tgcagtgtta gttctatata ggctcccttc tgtgcttctg 120 tttttgcaaa naccttgatt aaatttattc cctcagcagc ctgatccttg gccccttgag 180 ccgactggcc atctggatgg agcacgtgat acagctggac caagttggtt gcatcatcga 240 ttaaatctct ctgaatctgg tcaatcagca aaccatcaat ctttttatta tttacaaaat 300 accacaccat tccaccaaag tatcttgttg aacgtaaaag gtcatatttc ccacgtttat 360 ctatatcttc ataggtcttg tgatgaacct tgatatactc tgtggaatct ggctcaaact 420 gggcaaanca naaattgagg acatcanctt gcctgtcctg gctatactta tctaaaacc 479 <210> 588 <211> 556 <212> DNA <213> Homo sapiens <400> 588 ctagcatacc atanacttta tttacttatt ttgttctccc tactaaaatg tnagctctac 60 aaagacagat tttttttgta tatgaagaat tgattgtnaa cacacagaat ttggaaacag 120 tctctttcct caaancattt tgaagctgta nttgagggga angtgtctga ttaggggatt 180 gaatanctag gttgcagtac atccattcag tgaaatacta tgcaatggaa tattatttgg 240 ccttattttg ctctaatatg aanaaatatc agtgatatgt tgttaaatga aaaaagcaaa 300 ttgcagcaag ttgcanaact atatgtactc tgttttttgt aaaaaganaa aagaagtttt 360 aagaaaccag tagtttaaaa acttcacact gtgacttgtt tanatccana acctgttacc 420 tgagttagat gtcttgccca ttttctctgt tcatatgggt gtccnggaaa ccttaggcgt 480 tataccnccc anttttgcct atataactgt taatacttnc ccaacttggg ncanttcttt 540 tccccaatnc cccgga 556 <210> 589 <211> 474 <212> DNA <213> Homo sapiens <400> 589 actgatgtac ttaaaaatag tgcttcttac aaccaatggc atcttagagt caatgaaata 60 tggtagtttt gatcacagac aattcttgcc aataggttgc ctttagaaca caactctcaa 120 naaccaattc catggttcat tacttttata tccacaaaat aaagccattt ccaccctatt 180 gagggaaaga aaccagtcaa tctcgcagct gtgacctgat ctaatgatcg ggtccctcca 240 ttatacagcc caacagcacc tttccttgat agcacttacc acatcttcta agtaaacatt 300 tgtatatatt ttattaatgt tgctagactg gaaactcaac aagggcagga agcagatcca 360 tcttgaccac tttgacccct gtcatgtctc ttgggactan cacantgcct aaggcacatt 420 atttgctcaa taaacattta aagaatgaat cctatnaagg gttttaattg gaaa 474 <210> 590 <211> 474 <212> DNA <213> Homo sapiens <400> 590 ccaaaaattg aataagtatt tattgttcca naaggtacat tgctttttat acatatttca 60 taaatgatac aggattttac acatgttcaa tantttgcta tttgtttaaa naacttttct 120 ccatgtcctc cctcccttgc ttcccacaca ccccaaaaan atttgctcgt tgcactgtgc 180 tgtttcttct taaaaaccct atgcacaaac aggataaatg ggttaaaaat aattcacaca 240 acttaacaaa aataaatgag ggaaggagct gacaactggg ggtggtggan ggaaaaagaa 300 atgggcggag ggtcaggaaa tgganacatg catcctttca ttccgtcatg ccaatgaaag 360 gggtgttggc aggaatanca cancancanc aatcctggct ggccttcaac ctttgcaagg 420 cacctgaant ctgggttgtc atttaaagtt ttnctttcat acccaatnat cccc 474 <210> 591 <211> 559 <212> DNA <213> Homo sapiens <400> 591 aacaaggggg cagtcattta atgcagaaat ccagttaaca taaagagaca gaggttgaac 60 aacaggtctt caaacaatac tgcatagtgt cacnagttag ctcttaagca cgtttgatct 120 gtttatctta tgatttcgat tccagtacaa agacagagaa gagacttaaa aaaaaaaaca 180 ataaggcaac agaagaanaa tcttcctgtg acaaggaacg tccacaaata atgcacaaat 240 atttggtgct gacacaataa gacaccatca ggacaanttc tgaaaatgct gcattaaaat 300 ttaacaagca tgatacaatg acaagaaaat tatactcgct ttgttacgaa tccttttgca 360 agtaaaaatg acctcgggtn attgttacnt acaaactttc tgaaataaat ggaaatcata 420 cnaattttnc cattgcagtt tctnctttct ctaccctaaa aaattcccat gggcctgccc 480 ctattctcac antccaaccc taaatatcct taaagcnctt gaatccccnn tatcttncct 540 aaaaaggtng gnagtttgc 559 <210> 592 <211> 446 <212> DNA <213> Homo sapiens <400> 592 ccaaacgatt gcatttatta taaacaagtg tacagaccct agactcagaa acacaacaga 60 tttgagctaa gacagctctg gtgaaacagt aatagaggga ggaggaacac gaggtattca 120 tgtctgggcc agagctgcca tccagggccc cacaccccac ctttggtcca gatggcccat 180 tggcccaggt gtccctgctg ccagaacacc gtggactggg gtacaggagt tgttgcatat 240 tccatgaggc tggtgtcggg aagcagggac tcacagttgc caggttgtcc atctctgagc 300 caatttccct ccacaaccca ggggtttcag tctcatatca actatcctgt ttgaaacaga 360 aaacaggcaa aatgtttggc taaaataaaa tgaaaacact gcanggaaga nanctgantg 420 tgctggtgga canganccnt gctcac 446 <210> 593 <211> 470 <212> DNA <213> Homo sapiens <400> 593 ggccattcag acttattttt atttacttat aacatccatt ttctttttag aggttttaag 60 gtatctcatt gaaaattcna acaaaagccc ntgaganata caaaataaca ctgtnaacat 120 ttaacacata acataactga nataaggagt cngtaattta tcccaaacaa acagaaaaaa 180 taataataaa gtggatcctt gtntaanata attttaagcc ccnggaattg ttttctctag 240 tacaattgtn caattactga acattgacaa atattgattg cttanaatgt nccagcactt 300 gctaagtncc tttcttaana cctgccatcc tttgtaagtt gattttcttc ngaggggatc 360 ctgaaattaa ataaaataat cccnaattct tttagaatta cattgaaaan atgangttgc 420 ttttanaatc ncaatgtttt angacttttg gggtgtncaa tttcctgggc 470 <210> 594 <211> 591 <212> DNA <213> Homo sapiens <400> 594 cttgttctat ttctttattt tagctttaca ganattaggt ctcaagttat ganaatctcc 60 atggctttca ggggctaaac ttttctgcca ttcttttgcc cttaccgggc tcaaaaggac 120 atntcaggtg ggatacntnt ttctctttca aanctgaaaa aagggtctga gctgcggaat 180 cagtaaaaaa agccttggtc tcagtgactc cttggctttc aacccaccta gcctcanaca 240 gccagnaggc ctttttacca ctggatactg atganatgtt ttaggtcctt gcactttgca 300 aaactccttt ctcccagtgg gatattatta ggacataccc aggctaaaaa ggccgtggga 360 anctttggag gtangangat angatccana cagggttaca ataagganaa gggcattctc 420 tttggtgcac tccatantcc aatggcatcc tgaactgatc catttaggaa ccaagggtgg 480 acttcctcct tgggtccttg gncctttnga ttccccnact gggggcnggt tangaacntt 540 aaaaaaaccc cccccggttt ttcccccctt tctntccacc taaattcact t 591 <210> 595 <211> 394 <212> DNA <213> Homo sapiens <400> 595 ggctttagag aagcattaag aagtaaggca tgaaagcaca aaaagggaac tgaaatccaa 60 ttgcaataat tactcatgca attggcctct ttctatgtgg cattatanaa acctcctgag 120 taacacagtt tatggtttta caaaanaaaa ctcctacatc attgcatggc atggctaccg 180 cttccttaga ccattcagan aatgatcccc aagtattttt cataaacccc atagggtttc 240 ctacattaaa ataaagtgac aganatcacg ccttgaataa tttcacaatt acagcaatga 300 nttgtnctac ttccaaatga cgaattttct gctccnaata atgggacaaa aggcatcatc 360 ncatggacac antcnatttc ncagtgatgg actc 394 <210> 596 <211> 517 <212> DNA <213> Homo sapiens <400> 596 gaaaataaag tgctttattg ctgaggagcc cagagagctt cagggcggcc atctgggggc 60 taggactgaa gtcccctaac ttttggtggc tcttgtgaac agagacagtt gagacttcaa 120 catttcaacc ccatagaagg caaggaagtg cagccagggg aatggggagg cagggaagag 180 gcatgaggtg tgccgggaga gcgattatgt gcatctcttc ccaactctga gttcagtgca 240 ttcagtgatg ctggcagcat gacatgggac actgctggga gaatttacac cacagaagct 300 gcccaaatgc aataaatcag ggcttttttc ccctcccaga gaactggttt actatagacg 360 tgtgacacac cgtcccgagc tagtgctgaa cccacccaag cctggctact gtgacaagct 420 gtcacctccc cactcggggg gagtgccaac tcccagccct gcacatccct acaatcagca 480 naacagangg ggctgancaa angaaangga cnnaatt 517 <210> 597 <211> 588 <212> DNA <213> Homo sapiens <400> 597 gcaagttata aaatgtttat tgatatacat tttgtctttt ataaaacttc cgttggccac 60 attgggccac tgtgcaccac agtgccagtc cccangtggc cagggcggac cagtgtccac 120 tttcgggtgg gggctggagc caanaagctg tccanganct gcccagtggg tcctcatggc 180 ctgcgggata cctcaagtgc tcccggangc agcctaagac tggctcgtcc cggantcaga 240 aaangcaggt caactaccca aggcggccaa aggcccttcc tgtctccaga nccttgacat 300 aaccagaaat ccccccatca aagtcaccaa atgactccac ngggggaaag gaagttgttt 360 gcanaaaaac ttanctacna ggcatgtnaa ccagaacttt cttccanaca ccatttcctt 420 cacatttgct cactgataat gccttaaaaa gatcaaatct ctggaacaac cctnaatgca 480 ggataagctc tggcctgtnc tgctgggana catccaagaa gctgacccaa agcaaaantg 540 ctaggtggtt tttaccctcc tttacaacca cctaggcaag aaggcccc 588 <210> 598 <211> 603 <212> DNA <213> Homo sapiens <400> 598 ctcttacaaa actgtaacct ttatttgttg atccaacagt acgttaacca cttttacccc 60 atccccactt tacacggtac accaacctga acagattttg tgccacaatt tcattcaaag 120 ggtttgtcat tcactttatg attgtgctgg ataatctaga tgtaagcaac tctggagatt 180 ttaaaatatg ggtcccctgt atgagagtag catagtttat agcatacttt taaaaatggc 240 attcggtaat tttgccttct ggacagaaag atatcttcaa attgcaaaca catctatttc 300 cacaaaacaa tttggtcagg aaattttatt tgaacattct aaagcaataa tgctttagat 360 gttacttaag tgtcccagac aggattaaca aaattaagtg tctctaaatt acaaatttgg 420 ctcctgtagg agtctcagaa aataaacaga agaaaacaac ccccctccca aaagaagtat 480 gaccacacat tttgaanaaa cccaatgttt catgccatgg taggcaanan nttaaaaccc 540 ccccaatcac catttcctac ccaatctcct taaaaaaaat tnnccgttnt ccaatgttct 600 cca 603 <210> 599 <211> 294 <212> DNA <213> Homo sapiens <400> 599 acaaattctt ttttattagt caaaatcnca atcaccttga ttaaaaggat gggacactcc 60 accctcagca aaaaatgata cagtttatan aaaacctccc cgcccctccc acatcccaat 120 taaaaactac aaaaaaatct ccccnccttc cctacaatnt catggtnntc tgactcctcc 180 agtggcactg cagctctgga ntggncagct caccacagca ccctccactt caccttgggg 240 aaaagaagga tnctggtggt taaggaggtt aaaaccattn tttccantnn tgcc 294 <210> 600 <211> 497 <212> DNA <213> Homo sapiens <400> 600 ctcggaaact acacagacca tatgttttat ttaatgtgaa ggnacaactt taacattaaa 60 agcaaagcgt tttagttatt tatgatgtaa ctgtcagtac cagctcataa aaatatattt 120 ttgcaagcat atcattgaan actctttcag attgtcaatt caaaagtcaa tataaaaagt 180 cgaagtctat ttgtagaaaa tcaatgacac attatagcag ttccacataa tattattgct 240 ggacaatctg ttcaccanat atcacagggt tttcttcatt tgttgcacaa tccaaatggt 300 ccatcatctg atagctgttn cctttccana aacttttcca ttcccttact tctccaggca 360 acaactgagg cagtaataat tgtgcaaggt actaaatana ngaaancagg tgcccctttt 420 tcatcancac cagaaacaac aaatgttatt ntcatgccaa aagcataggc nactgtaaac 480 aaacatatta tatntta 497 <210> 601 <211> 467 <212> DNA <213> Homo sapiens <400> 601 gcagtaattt aatttaataa aataaaatta taagaacaaa aagttacatt tctaaagtac 60 caaaactgca acaggntcat ggaacagaac ctagggatcc aagaacataa gaagtggtgg 120 tgctgggcaa ggctctgcat cccctttcct cagcacagca ccatcttcac cctcctggga 180 aagcagcatt ggagcctaca ccgcttgtgc ttttctcacc agggtaagaa atgcaggtat 240 ttgcanangg gaatgagtct ggaaagtggc anaacacanc tagggcaaga cttaagggaa 300 cttgtgggaa naataactgg aacctaccta tgctctcttg accccaaact ccccaaaacc 360 cctcactgan gactgtctac ccccggggct canaataaac tgcttactgg aaaattggtn 420 actttaggcn aaaggaaagn tcctcccggg gtnccccatn ccccgct 467 <210> 602 <211> 489 <212> DNA <213> Homo sapiens <400> 602 gacatttcaa taaaaattta ttgaaatttc agtgatgttt taaagagagg gggaaaaata 60 cagaaaacca aagaactcat caacaactat aacacaaaat ataccttcat gaatttgtct 120 ttaaaccatc tctcagcacc tgacttttga actgtgaata tatctctata ggcaggcacc 180 aattcaaaac accgatactg acaacagtag taaattccac ttcgttttga ggaaatcaga 240 gactancaaa tacaaatnac aaaagaaaaa ttaaaaagtc aaaccgcagc ctctgccctc 300 ctccctcccc acagcaatct cagttntntt ttaaggaatt tgaaatggan ctggaaantg 360 gccccctncc ccaattttgg tgaaaatagg aaataaccct ttcccccact ttgggacttt 420 naaaaanaaa acaaaantnt tgcaaacaac tcttttgaaa gggttttggt nttnggcaag 480 anttttttt 489 <210> 603 <211> 554 <212> DNA <213> Homo sapiens <400> 603 ggagacaaat caatgtgaan anactttaat ggcaaagtgc actgganagt taaaatggtt 60 acatgggtaa tttaagaaaa aatttagtgg gaaaaaggga aagggctgaa ctgccaaaat 120 aattttctta tccagtttta catttgcttt ctccatgtgc tacaattata nacacctgat 180 agttcctanc cttagacata acttgcagca tcagccactc tgctgcactt tanatcacat 240 tagttagggc tanagcccan ccccatttac acggcatctg atnaatggtt agctgtggca 300 gttctaccat aatgccattt tgctccaaaa aaatccantt aagtngctgt ccatggccca 360 ntantttcnc ctctgttgcc cccaaaataa ctttgggatg gccaaggaac anctgtcctg 420 atttgggcca tttaggaaaa aatggcataa actaattttt cctttaggct tggatttttn 480 ccccccatct ggggttgaca ntttccttcc tgggatccca nttttaggtt tcataaataa 540 ctcccccttg actt 554 <210> 604 <211> 417 <212> DNA <213> Homo sapiens <400> 604 agcagatacg tttattcaac acagtgcatg attcaaagca tcggatattc cacagccaac 60 aaggtttcct attccctatt acaaaatacc ggataccctg aatatagctc attcaaggtc 120 ctcgttcctt tttccctata tctagaatta aacaggtttc cccgtttagc gcacatttca 180 cgttcgctga aggctttggg ganaggggga aacaganctt atgactgccc ctctgaacca 240 aaggcactta atgttaaaag ataaagcaca gtanagtcac cccacagaca ttcctatgtg 300 ttcaacggct gaacttcanc ataccatcac cgggncccat gtgggattca tcataacaac 360 ntnaaagaca ctgatttcct tggnaaaaac aaagtgcagt acgaatatna aggantc 417 <210> 605 <211> 547 <212> DNA <213> Homo sapiens <400> 605 aacttctana aataaatttt attacattta tagttgtatc ccnttgtgtg anataattag 60 ganttctcta ttaagtnatt aatcctaact atatccttgg ggtgaattga attctgcccc 120 cacccgaaag aatgaccttg tccccttccc cattccanct caaggcactt aatattacaa 180 aaaaaaggan tggctggctg gaaaaatggg cctcaagtca gaaatccccc agtgcaactt 240 aagacaaaca gagagaagtc accttcctct taggaccctc cctgggttng cagaaggaaa 300 gaaccagaag tcttcagtac cacagtaggc ttcggtatct ccctagccag gtgagggacc 360 cccaggcatt ctccctgccc gcaccgagtc tctcttcacc tggctacttc ctggccacac 420 gtttgantct gcccttactt tctgctctga nctgcctgaa tacnggaacc anaattccct 480 ctgaccnaaa attccnaaac ccngcaagga ggccccccac tttcaaaaat ngggaaccaa 540 atggccc 547 <210> 606 <211> 533 <212> DNA <213> Homo sapiens <400> 606 ccaagtcttc acaaaatttt atattcccca agggtgcccc atcacaatgc ctgtgaanct 60 tgantggnaa anactgaagn ctgaactggg ggntacaggg ggtcctggct caccggtccc 120 ccccgtaatc tgtaaaacat actgggcnaa ggaagctgct ggaagactga atctctccct 180 tctccaggca ataatgangc atatgcctgt tggccttggg cccattaaan atcattccan 240 ccccagtgct gttctctgaa ttcttgggga acacaaggat gggggctcct aatgangacc 300 canaaactct ganctctcac aactttcaaa ggacacttgc ctccctcctc tgcccacacc 360 tccaccatta cagcatttga tccncaaatt aagaaggggg ggtcctattc cacacctctc 420 ttgtttcccc ccaccctctn aattttttta aggcccnaaa aggtttnaaa ttagaacccn 480 ccctcctggg ctnaaaaaat ttctccttcc ccctnttttc caagnatttc tgg 533 <210> 607 <211> 479 <212> DNA <213> Homo sapiens <400> 607 ggtagaaaca ggatcttact atgtgggcca ngctggnctc aaacttctgg tctcaaanca 60 atcttcccat cttggnctcc caaantgctg ggaatacagg gcatcagcca cctcacctgg 120 ccaacctggt atttttcttt cactgcattt cctgantctg taattattat tattatgttt 180 taaaganatg aagtctccct ctgtcaccca gtctggcatg cantggtgtg attgtagctt 240 actgctacct tgaactcttg gactcaagtg atcctgctgc ctcagcctcc tgagtagcta 300 gagctgttag cacataccac catgcccagc taatgtttaa aattttttgt anaagtaggg 360 ggtctcacta tgttacctaa gctggtttcc aactctgggc tccantgatc cncccccttg 420 gcncccaaat gctgggaata aatcntaact gccccaacan ccggnaataa nttttttcc 479 <210> 608 <211> 478 <212> DNA <213> Homo sapiens <400> 608 cctaagcatc tgctttaatg anaanggtcc tgttcatgcc atgcctgtgg ttgactcagg 60 aaacangcag ggggataccc atggctccna tgganatggg gatggggana ttgtggacaa 120 agatgcacgg tggcggangc ccttgcagct ttanaagctg ctactgcagg anaanatttg 180 gatgaaactg attaggggag gggatttgca canggaggta agctggtgtc atgctganca 240 tgcanatgca tttgctccct ggatgcatan caggtgattc tgccagcatg caccantgca 300 nccttaccag ttgtttacat ccagcatctg ttctgattgt cancatctgt cccatgctgc 360 ttgtcacata tctggagttt cactctgtgt anatganctg tcattcagga cactgctact 420 ctgtnccact gcgttctctc tcccaggttt tncccggcnc tccccnttga cggttccn 478 <210> 609 <211> 531 <212> DNA <213> Homo sapiens <400> 609 ccacggaaaa cagccgtttt tattccacaa acagtaaact ccatccacta cacagtgaca 60 tacactgtgt agcacacccc atcaccttgg ccagtgctgc cagccgacct ttctgtggtg 120 atggaaatct ttttctgtgc tgtccaatac agcagccacc gaccactttt gcttattgag 180 cacctcaata tanaggtggc cactacaggt gaggaaatga atttctaagt taattcaaat 240 tcaaatgcca catttggctc gtggctcctg tactggacaa cacagctgta ggccctgacc 300 tggtccaagg cactttggtt caaaanccac tctgaagaaa ncaattggca aaaacagccc 360 ttgggctccc ctccccaaaa aaaaaacggc agcttgcacc tgctggaaaa gggcaaaaat 420 caaattgggg ggaccctcng gccccccnga aaaaggttgg ccaccccctt ggccagnccn 480 cctnttcggg ggcnccccaa ttttaaaggt ccggttaaga aaattttnaa a 531 <210> 610 <211> 510 <212> DNA <213> Homo sapiens <400> 610 ggttggacag gtttttattg gaaaatcagg aattactttc cttccctcgt ccctgcctcc 60 cccactcaaa naacccactc cagtggggnt tgtccttcat ctgcccctan gaatccccat 120 ccccagctac acaggcactc aggganaacg cacatgctgt gtgggcagac agccccaggc 180 caggtangca gtgagctccc tcaaatcctc ccacccccag gactcangan ggaggggcag 240 gaaaagtgtg ggcccggtgt gcantcctca ggcggcctcc tgagctcgca nccagccagg 300 ccttgtgcct ccagnatgga tggtgtnatg angcacatgc cccntaacct ttcccttccg 360 gaagggctta accaaaaaat ntcttgttta aggggcttgg ganaaggttg ggaaaantac 420 nggaagacac ttaactcttc ccccttgaat tgtttcccct ccaaaaaatc cccccncccc 480 cnaagaagcc ggaaccnttt tncccnaaaa 510 <210> 611 <211> 596 <212> DNA <213> Homo sapiens <400> 611 aactgagtct ggttgtttat tgaatgcaaa ttcattcata gaaaacggaa atgcaaccat 60 ancatggaga cgctctgaga aaagatccag anccacctca tctcccagcc cttcaagcag 120 agctataaaa acaagtttgg gagaaaaaca cattcccatc cccaaagcag angccccgcc 180 tganctcccc catcctcagc atctggggtg gaccangtgg gacnaaaggg atccaaggac 240 cagggtggcc anggtgccca aanctggggc aattctttgt aaactccaag gtttcatagg 300 tatgtgtgtg catgactaac acanaacttg cctgaagact ggacggaaac ttanaaacca 360 ccctgggtcc tataacgagg ctangactgg gcacgtataa ggaaacacac atcccttcct 420 gaaacccttt tctaagttag gcctggggtt tcccncncct ttggaagcaa acgggctgaa 480 tcttttctnc ccccctttgc ccctgaacnt ccttgggcnn tttcatggcc ttaaaaggcc 540 ccccttgggt ttggcaaaat aaggccttaa aaaaagaaag gaanggttag gcctcc 596 <210> 612 <211> 380 <212> DNA <213> Homo sapiens <400> 612 gaggcttgga attgatttat taagcacatc ccttgccacc ctcccacctt aaaagttttc 60 agtatcaaaa gaagctagcg caggccaccc gagtccctga ggttggagtc ctagcatagc 120 tcccctccct caaaaaggga caaggggtca ggggcaaaac aaaaatccag tctgcttcaa 180 ccacggagac tgcctttggg atggaaagtt tctggagctc cctccattct attcctgtgg 240 ggcaggaaca tgccagggct gctggtaaat ggcaggggtc acctttacca gggcgcaggc 300 atantgtggc ccctgcctgc cctggggcca ccctgnaaca gtaagaccct ctggganngg 360 aanaaaccag aacccnccnt 380 <210> 613 <211> 369 <212> DNA <213> Homo sapiens <400> 613 gaggcttgga attgatttat taagcacatc ccttgccacc ctcccacctt aaaagttttc 60 agtatcaaaa gaagctagcg caggccaccc gagtccctga ggttggagtc ctagcatagc 120 tcccctccct caaaaaagga caaggggtca ggggcanaac aaaaatccag tctgcttcaa 180 ccacgganac tgcctttggg atggaaagtt tctggagctc cctccattct attcctgtgg 240 ggcaggaaca tgccanggct gctggtaagt ggcaggggtc acctttacca aggcgcaagc 300 atantnttgc ccctgcctgc cctngggcca ccctngaaca atnaaacccc ttggaangga 360 aaaaacnaa 369 <210> 614 <211> 584 <212> DNA <213> Homo sapiens <400> 614 aaaggtttct gtcctttaat tttttaacag aatatacaga gccacacaat acgatttcaa 60 tttcaaatta tgggagatca tattcaaata tgcttaggtt tgacaagttg ctgttacaat 120 actgagaact ttcatgaaaa cggtatttaa caatttttaa gataatcaaa tatctttttg 180 ctacgtgggc caacgcatta atactaactt gtttaaaaat gcagtctttt agacttcaaa 240 ttattataaa acaatatcaa gatcatatag atatacttcc tgattactca aaactcgttc 300 cattctgatg gaggctgaag gtaaatgtta ttatacatta gaacatttca tgaaaccact 360 tctcctttgc acttacctgt aaaagtcaaa aattaaacca caatttccta agacataact 420 atttctagaa tacattggtg ttatcataaa agactacaag ttaattatca tttttatact 480 aacacttttt accacaacca tcttcctaaa aanaccaaaa aaattnggaa tttggattcc 540 cctacataac aggatccctc cttccgaatt taanaatttc cccc 584 <210> 615 <211> 481 <212> DNA <213> Homo sapiens <400> 615 aaagcaaaga actttttata gtgtttatta gatcaaggac cggttagata gatgatgggc 60 taggcaggtg ggggaagaca gagctcactg ccctgtgggg tctctgtggg gccagcccct 120 gatgcccatg tggccactga tgcccagctt cccccaacac cccaacacag gcccaggaca 180 atattacaaa agtgaacaaa tgcaaccttt ttctgctttt acaaatgaca tgtctccatc 240 cccggccagc aggggtaggg gaggccggtt gaaagtgaca ctccgttaaa aaggcaacaa 300 cttttataaa atgaagacta aggaaacagc ccagggttcg gaagctgaga tgctaccctg 360 ggggtagagc atanacatgg gtcgggcaga ccttgtctcc tttcacggca ttcctggagg 420 gtaagaaggc tgtctgctca ggccactggg gactgaatcc aggagnccct tganntnnnc 480 n 481 <210> 616 <211> 383 <212> DNA <213> Homo sapiens <400> 616 acacaattgc agganatttt attggcccca tgacatccag tgacagtgtg ggancangct 60 actctccagg gacatgtttt tgggaggcat atgganaaag gggccaagcg angtggctca 120 cacctgtaat cccancactt tgggangtcc angtgggang atcccttgag gccangagtt 180 cgagaccacc ctgggcaaca gancgagatc ccatcactac aaaaattcaa aaaattagcc 240 aggcatggtg gtgcacactt gtantcccag ctactcagga ggctgangtg ggagaattgc 300 ttgggcccan gaattcaagg ctagagtgag ccgtgaccac cantgcactc tancctgggc 360 aacaganaaa naccctgtct cnc 383 <210> 617 <211> 564 <212> DNA <213> Homo sapiens <400> 617 cctttaaaaa tattttatta agcattgatt tagaaaacgc aagacaaggt tgtaacacct 60 cagggcaaag gnttgaaggt gaaacaaata acactataaa tattgcactt ctaaaatctt 120 tttttgacat cttcacacaa ctcaattcta aaatatcctt ttacagagat gtataaataa 180 acgcttccaa gctgtcaacg cttgacactt ttagcttcct atcaccgcac taagtcggca 240 ggtttccaat cagatagctg ctcctctgac agcaggcaaa gaacttccct cagctatctc 300 ggaggcctca tacctccatc atgtgaagag tcaaccagtc ccatctttcg gaatcctctt 360 tcagaatatg taattttata agtatttttt tttctactga ganaacatan atctttcaaa 420 ggcaatggca gaatacagct taaatggacc agttccctgt taacattgct tattttttaa 480 ngnatccaag aactctgatc cttggtcttg aacatcatna naaacttttt ggcatnattt 540 tgccnccccc acttcnccta tttg 564 <210> 618 <211> 318 <212> DNA <213> Homo sapiens <400> 618 gtggatttnc cttttaatgc aaaatgttgc aatacaaaac aatgtggaaa aagtcctgtt 60 cctcaggaca ctgaagggag gagtgaggaa aaaaggacag agctggacgt ctcctcctat 120 ttctccctcc ccaagtcact ctgaggggaa aaacactgct gcctgctccc tgggcctgcc 180 cgcatacaan gttagagccc tgggtctggg gcatccttag cctgaaattt gttgacatgg 240 ggcanganaa caggagggaa cnttgagggt tttgactctt cgggctctaa aangattact 300 caggatctgg anttccgt 318 <210> 619 <211> 554 <212> DNA <213> Homo sapiens <400> 619 atttgtacaa acaaaaatca ctttattcac atgccagaac agtgtttgag tagatagttt 60 taagggcaat acaatcaatt tcttgaactc agatttgaat ttttaaaaaa ttatattcaa 120 gctctaagta ttttacttac agaattttgc acatggctca ctcctttctg cacaaaggta 180 aaataatatc tttatttgct taattcccca ttgttttgtt gtttcaacat gattttgtac 240 cctcagtctt tcaacgttag tcaaacgtta cattttcttt cactcttacc cttttttgag 300 cttcatttcc tctctttatg ttctcgagta tagcttcgag gtgtagggta ttcattccca 360 agatccacaa caattacctc cctagaaaat gtcactcctt ttaaaggtct tttttggctt 420 tcaacaactg aaggagttct agtgacagat gtgtgnattt ttctgcaaac catcattccc 480 ttcttggcca ggttcttcag cnttctaagg ctcttgtttc canttanttn gggtctcccc 540 ttntgcccca aggg 554 <210> 620 <211> 587 <212> DNA <213> Homo sapiens <400> 620 acactgtcta aagcatttaa tggtctttct ttaacacagc caactccccc gggtttgaaa 60 cagtgttaaa ttctctcttg cttgtggcaa aagaagctgt caagtccaac actgaaaaat 120 tggtaccatt tcctggccag taagcacaga acagaggggc taaatatttt atggttttat 180 ttatttactg tgttctcatg ctgtgttttt cttttctctg tctctccctc ctgctcgtgt 240 ctgcccaggg ctgattgttg tgacattggc cgtatgctgg atgcccaacc agattcggag 300 gatcatggct gcggccaaac ccaagcacga ctggacgagg tcctacttcc gggcgtacat 360 gatcctcctc cccttctcgg agacgttttt ctacctcagc tcggtcatca acccgcttct 420 gtacacggtg tcctcgcaac aanttcggcg ggtggtcgtg cangtgctgg ctgccgctgt 480 cgcttgaaca cgccaaccac gagaagcgcc tgngcgacat gcgcactcac aaccgaaggg 540 cccgtttggg caacgcccgt ggtttttgng tccggggcca gnctttn 587 <210> 621 <211> 550 <212> DNA <213> Homo sapiens <400> 621 ctctctaaac actatggatg ttattcattt cccatttttg agtcgtttta ctggagtcac 60 aattggagat gaatacttga tgcaggacct ctgagcgatc taaacacttt cctgaaggaa 120 tatgagtaaa tctgtgcagg ttcttgaagt actgccattc cttaaattca tttagattac 180 agtgtgtaat cataactttt gatccatcag ctccctttgt caaacactgg tcatactgca 240 tgagttgatt tgcttcattg attctgaaaa gctgattccc tcccatcctg tggcagggtc 300 ctagttcaac aaagcctcca tttgtttttc ccatgctatc aatgcagtaa gcagtttcga 360 agcctctgat ttctccccag tcaacatttt tgggtggcaa agggtagtgt gaggtgatat 420 cataagctat ttcttccatg aacccttaaa acttttgcag ttggggacct tntcgaaatt 480 tttcangttc cgaaatatcc cctatgggaa tgnctggcga ttaaggccna cttgccttna 540 aatngncttt 550 <210> 622 <211> 544 <212> DNA <213> Homo sapiens <400> 622 gagatgaagt tttgctttgt cgcccaggtt ggagtgcaat ggcgcaatct cagctcactg 60 cacctctgcc tcctaggttc gagtaattct cctgcttcag cctcccgagt agctgggatt 120 ataggcaccc accaccacac ccagctaatt ttttgtattt ttagtagaga tagggtttca 180 ccatgttggc caggctggtc ttgaactcct gacctcaggt gatctgcccg ccttggcctc 240 cctgtgctgg gattacaggc gtgagccacc gcgcccagcc tattcctatt aattctttta 300 atccttgcaa cccaagttgg ctaggccgat agcattaata gtcacattct atgggtgatg 360 aaactgagga taaggaagga tacacctgac agaccatcag gaaacccggt gggctccaga 420 aataactggt tgctagtgaa cccgccgncc ccatgagtgg cccaccttca ttaagacccc 480 acccctaggg acactacggt tgaggtttgc cttnggggcc aaaggtaccc cggggnanng 540 gnan 544 <210> 623 <211> 549 <212> DNA <213> Homo sapiens <400> 623 aagcccatac ttagtttatt ataggcatgt ctaattgaaa tccatgaaaa cagttacatt 60 taaaacattc tttatgcact atacttgaaa atgtaaaata taataccact taagtacttc 120 ccacattaaa ctgatttttc tttttttaaa aaaatttttc ctagtcgtta tttagctttc 180 ggacaccata atacaataga acagaaagag tatgttaaaa gaaaaatatt aggtagaatg 240 ttgtaaaact tttaatttac ccatcatatt taacatttcc aagactattt tcctgcgcct 300 catctgccct cagagagaat gatccccaca gtgatgaggg gtcagcactc tgaaagccag 360 ttgacgccag acaagctgct ggaacagctg gggcacagct ccgcctctcc tccagcccct 420 cggtcccatg aggccaaaca atgaggacag aggggctgan gggtgtgtcc agggcccagt 480 cccacctcag caggaangtg gcgtcagcac tcgcagtccc aggcttacgc cgnatngcag 540 tcccagggg 549 <210> 624 <211> 373 <212> DNA <213> Homo sapiens <400> 624 ccaggacaaa aaataaaata tttattgatc tatcacagcg agacacaaaa agatgggcgg 60 ggcaggaatg ggaactgctc tgaagttcag tggaccgagg gagggatggg gggtatacag 120 tactgcatgt ggggacaccc cgggtgggga ggagatgcct ggcaccccag tctgcacagc 180 cccgcacgcc ctgggggagt ataggatggg ggtggaggca gggcacaggc ggccatgaca 240 ggtcaaccag gttgangcct actccaccga gagcccngag ccctccaagg accccaggca 300 ctgntgtccc atattnggct gctttanccg gcaccagggc nccaggtact gccccnaagc 360 caggaacacc anc 373 <210> 625 <211> 576 <212> DNA <213> Homo sapiens <400> 625 aacaagcaaa ttttaataat gccttttatt tctatacaaa gcaatgtaac tttctgaaaa 60 aaaaaatggc tatacaaaac cctttaaaca taagagtaca gagcttcaaa tggcaacaag 120 aagttaagaa acatagggca ctgtgtcgtt atgggtgaat cctagtcgtc ctgcagccca 180 aggtccaagc tagtttactc cataacctta agtaaataac cgcggttcct atgaatacct 240 ttccaaaacc atttattata aaaactcact ctttatccat tatcagtatt aacgtatcaa 300 agtgagaaag aacatgggag agaaaaatga caattaatgc agcgtgaaca ttttcatcct 360 gaataccagt aaggactcta gatgatatat ggtgcccact tcatgtgcct caaaagattt 420 taattttcag aacatttaaa cgattaaaga gaaatcatcc tcttaactag gtattttaaa 480 gcttatcaaa ctgnaggttt acatttgaca aagcttatgg accacccaat acgtagaaat 540 aggaattnca aatatttcag ntcgtggaat atncaa 576 <210> 626 <211> 506 <212> DNA <213> Homo sapiens <400> 626 gcagttctag cctttatttt tctttgacga ggagtgccac actgagggcc cctctgcagc 60 gccgcacagg gaagcggtgc ctcggggagc agcctttcct ctgatggggg gaggggtcaa 120 gggatgcagg agatccacgg cagcacacgc agcctgcagg cgcagcacac aggcagagca 180 ctgcccagca gctggaacat gagaatgagg gccacaccac ccagctgcag cacaagccca 240 gcacggcgtg tcacggcacc tggcaccacc agacccagaa tggcctgtgc gagaggcgca 300 cgccactgac gtggctatgc ttgtgatcaa agcccgacac gccggaagaa gagccgcaga 360 cattgngggg tgcacacact tgcagggaac tgtggagaac cctgatgggt gngttaggac 420 aaacaaggcc accatncttg ggacaanacc caaggnccaa gccttggntt ctaagccggc 480 cccanttttt ttggcctttn aggggg 506 <210> 627 <211> 461 <212> DNA <213> Homo sapiens <400> 627 agnggaatta agtaaaaatt ttgctatgtt aaatttgacc ttttcccaac agaaggcatt 60 tccttagcta ccagcaaggc ctanacacaa acgtctggac tgtagtctct gactgccgtt 120 cccttgggtc caggcctntg gcgggagggc gggacccctt cctctgactg ttcccggggt 180 caggccatgg ggatgcacaa ggccacaccg tgaggcagga gttcgggtgg ggcagggccg 240 tggactgggg cacccaccag tcctggaaaa cagggctggg acgctgctct gtggcctcag 300 acaagcttgg tgggcgacat gctcaagtga gcaggggccc caggccacgt tcaactgtcc 360 gcgaggcatg tgaatctgan atggggctgg ctnctgtcan aagcacttaa cctgaaatgg 420 ggctggcttc ttgccgggac actcgnttnt ggncctnttt a 461 <210> 628 <211> 542 <212> DNA <213> Homo sapiens <400> 628 gagacagagt tttgctcttg ttgcccaggc tggagtgcaa tggcgctatc tcacctcact 60 gcaacctctg cctcccgggt tcaagcaatt ctcctgcctc ggcctcccaa gtagctggga 120 ttacaggcat gcaccaccat gcccagctaa ttttgtattc ttagtagaga cagggtttct 180 ccatattggt caggcttggt ctcaaactcc cgatctcagg tgatctgccc gcctcagcct 240 cccaaagtgc tgggattaca ggcaagagcc accgngccca gcacggtctt ttcaaagacc 300 agataattta tttaaccaac tgtctaaaga tggacattgt gattgatcac actattttat 360 atgtaacatt gaatggagtg ggtgagtcct aggaaacatt ctctnctaaa aggttacatt 420 tttcattggc tagaaagtgc cnaaatagat ctactggtga gaaaagacnt ttggaagcnn 480 tatgggcaag gtggcaggtg aatggcctna anacttaaga attcaattgn tacttaaaaa 540 an 542 <210> 629 <211> 554 <212> DNA <213> Homo sapiens <400> 629 gccggaataa aggtttattg tgctggtgca ttatatctca gcacctggag agctgtgcag 60 aggttggggg agccccagat ggagggatgg gggagaggac ctcctgccag agcctcccta 120 aagcaggacg gagcccaggc tccctgtcga ggactgacga atattgngga cacaggctgc 180 cagacaatgt gtgagcaaca gggggtggcc agggcccccc tgctccaggc tgggcgtcag 240 aaacccttcc ccagcccctc ggacttcccc agggtggagg tcccctcaaa cacagcccct 300 cagcttctag gctgctttgg aggccagaca ggaagagttc cattcattca acctgatccc 360 agcagcagta gcgggatgag aaactcaccc ccaggcccgg gggtgcttgg anagcgcttg 420 aaaggattta aatgccctat ccccacattc ctaatctgga ccactntgaa acaagggggc 480 caccttagga aaattaagaa ccgtatttcc aaaanggntn ctgcaggatt taaccctgaa 540 ctgtttnaaa aaga 554 <210> 630 <211> 572 <212> DNA <213> Homo sapiens <400> 630 aggtgtcaaa cagcagagtg tactttccaa agaacatttt tttttttttt acacagcaaa 60 tcccaagcct tcccagtctc acacctttcc acccattcat aaaaaaacac acgaatttct 120 cgcaagttcc aatatcactg tctctttatc atctaaatag ggccagttgg acacctcatt 180 gaaacaaaaa ggctgatcta gatgaagtac tctttctttt cttcggagtt gttctgtcct 240 ccttctgcat tgattatagc tgtgtctgcg tctgctgcgt catcggctcc tttggcttca 300 tgagtgaagt atgtaccttt atgtctggca aaatagcgcc ccagaatgat gagcaagcac 360 agcatggcga acaccaccac cgccacgacg ccaccgatca cggcatgatc cactgccctg 420 atcgagcctt cttcacctgc tcgggaatct gaaagggcct cactgtccag gtctttctgc 480 ggaaatgggc caactggagt aagggccgtg aactngtggg ttctggccgt cccccggttg 540 ggncggatnc ntacnggntt ttaatccgng gg 572 <210> 631 <211> 499 <212> DNA <213> Homo sapiens <400> 631 attcaaataa aattttaatg atttcagttc ctgaaaatgt agtgtcatta aaggtcattt 60 cctgctaaat ttcaaattac agatttgtgg gccattcctg agcagaagca tcatttctac 120 taaatattca gcttgttaac taaggtaact gacagtatca tggcaggagg tgagaaggag 180 caatgatcag ctcatagcta agaaaaggga aaaaaacaat aaccaaagca aaaaacaaaa 240 tagctacaga tattagtaaa ataataatac aatcccaaac atccacctct taaattacta 300 caaaaacaat accaataaag ttatagcaaa tacagtcttc acagatttga gtaactttat 360 ttgcatttta tagtgatttc ttaaggccta tatccaatga aaccatttta aaagctctat 420 ggagganggg gattttaaaa ggctantacc cntggccttt aaaagaaaaa tgcntaaatt 480 tcngaatgng ccagantca 499 <210> 632 <211> 553 <212> DNA <213> Homo sapiens <400> 632 gtgtttcatt ttctgtttat tacttgaaat cacggtgctc gtgtaggttt tttttttttt 60 ttcaatttta tgttttcata cataaagggg gggagttgag gacctggggt tcacctacga 120 naacaacggt gggggacagg canagccagg acaagaccga caggtggggt gaggaagggt 180 ccanacatnt ccattatcat taaaaaataa aaagngggtg gggaaaaaaa tccaaaaact 240 accccattga aatggcccca gtaggggatt tgtccctccc ctttggagac agacacccct 300 agggcagggg cactganagg cagggggtcc aaattagacc agcagcggac cccgccacgg 360 gggttaatgc tacacggagt tgtcgccccc tgcccagggg attcacagnt cagcaccccc 420 tcccatcctc gctgcaggag gggcccccag acagtcccaa atcccatccc ttaggttggg 480 cccggaaaga aggctcggan gggggaactc ccagnancca gccatttttt cccnttttta 540 agagttccca acc 553 <210> 633 <211> 545 <212> DNA <213> Homo sapiens <400> 633 aaggngcccg gtagctttaa tgagcacctt ttcctcactt tgnccctccc tctctactct 60 tccccttccc gtcttgacag gtccagcctg ccctagggct cttaaaccgc aggtatcaat 120 ccttctgtcc ccttagccgc tccaggcgcc tgcgaaggtc cgggggcacc ttggccccag 180 ctgccagcag ctcgcgcagc ctctgtttgg gagtcttggt gagcacgaaa ttgcagggga 240 aggggccctn ttcaaaggng acccgacagt tccgtgtcac tgaatggtag ccctcggcac 300 tggcagtcac catgtagtcc cctggggtca gcagacgcca ataatccccg ccccacgccg 360 tggtcacgtc atggttaatc ccatccacgg naatgacaag cgtcaagcaa tcccaagctc 420 cgnggtcctt gncccttacc acttctgcaa tggccatgcg cacctgnttc aagtaaggtg 480 aagaaggccg cttttgtggt ctnccacttc tngggcaaat tnattcttcg ngangggaac 540 ttgtn 545 <210> 634 <211> 561 <212> DNA <213> Homo sapiens <400> 634 gtagaaaaag gctgactttt attttcctgc agagcatctt cctcgggaga gcagggagcc 60 ccaagtcatc gagttaagag caggagaatc cccttgacta ggttggggtc tgagcccaga 120 ggcagggcct aaggaggtgc agagactagg gccgggagtg gtgaggcaag gttggggcct 180 ggagggacag ctatgaccgt tgaacttgca gaccctggtc caccttcttg gagtggaagc 240 cagcggtgca gaaggggacc cctgaggcgc agaggcaagt aacagtgcca ggggagtggt 300 cagggcagat cctttccttc tcaggaggct gttgaggggg agagtgtcat gctctaaaca 360 gtgaagggac agatgacttc cataccccac tcttccttgc tggtgagaag tggacccttg 420 gagttcagtg gctgaaactc agaatttagg gtatggagct ggacccagag aataaagtct 480 caagtagtan aangggcatn tccttcagtc catggatttg ggcctttggc atgaacaacc 540 anggcctgga tgttaaggat t 561 <210> 635 <211> 359 <212> DNA <213> Homo sapiens <400> 635 atgagcngca acaaattatt tatatgaaca ttccaggntt cagttaacta accncattcc 60 actcaactta catganaaaa aattgggggg tttttanaaa ngggatttaa tatncaattc 120 agngttaaca ttggtatgtt taaaagaaat taacccanat aaaaagaatt tggcctntag 180 ggaaaatcag agntctactc aaaatataat actaccaata aactactagc atagggaatt 240 ttcaggatct aattaaaagc ttggtcaatt tgatggcgaa ntagtgncnt aagggacatg 300 agaaggaacc gtacaaagcc cnttacccng cagtattgga atcgccntnt ttatagctg 359 <210> 636 <211> 581 <212> DNA <213> Homo sapiens <400> 636 gaaagctaat agacccttta atgcatgtcc aggttaaaaa ataataataa taaagaaatg 60 cttctggtgg cccttgagcc aactgttcag gtgtggagaa ggggttcagt cctggccgga 120 gcaggcagga ataaacgtgg gtgttcactg cggccagcag ctccctcaga cacaaacacc 180 gtccttcccg tggtctggcc cgttgtcgtg taagcggggg acaggaagca tgagggagct 240 tgtggaggtc gggccacgtg ccatcccaga catcaagagg ccccaatggg tttttacttg 300 tttctcgcag tctggagggg cagccatgaa aactccaagc gccccttggc ataagaagga 360 gatgccccag actctccacg tccagaaact ggtgggatct ggctcatggg gaggggcaga 420 gcggcagtga taggacttca ggtgagccca aggggctggg ggaacagacc cagctactga 480 gcaccctgcg gcatgagact tcttgaaaag tggggaacac ngggccttca ggactncgtt 540 gccttttggt gggcttggtc aanagttctt gagggnggaa a 581 <210> 637 <211> 584 <212> DNA <213> Homo sapiens <400> 637 acatttcaaa tatattttat tactttccat cttagaaaga atatgaaacc tgcatgcaat 60 gctaatggtt tctgacatgt acatagcata taacacagca gtacaatgcg gcatatactg 120 gggggcagtg tgtggagggg gcgttcttaa gggtatatgt acagaggaaa gggcgcatgg 180 tcatcttagc tttcgaaaga ggactgcact gtttaacatt gaagaattac atggggaatc 240 acaaatatat tgctttagta ctgcatgttc tgttgtggtg agggaaagaa acatgctttg 300 aaggttttcc cttgtcaaca gaatgtgtgt ctgtagctgt gtattgcgca tgtattcata 360 tatttttaag ttttctccta aggtttttgc tgacagtgtt gggaacctca catgcttctg 420 aagcattaaa tattgaacct gtgaaccttt cagaaatcct caggatggga aagaccccac 480 accttcttta aggatcattt gcttcgccat cacaggatct tggnaaaggt ttctaaggtg 540 gggaaaaatt aacccagggg gggaatgaag cacatttttt tggg 584 <210> 638 <211> 570 <212> DNA <213> Homo sapiens <400> 638 aactcagtaa ttcctttatt ttgattttaa attaatcaca accatcgaag tggtaagaaa 60 cagctgacag gtgtacttaa aaatactgaa ttgacagcta cattgaatgc agggtttccc 120 agggtagttc ttattttgtc acttactcca attacattca aggtcgttat gcctcatctt 180 tttcctgagc tgtggcagct ctaactgggg cacccagaga gatacatacc aggtaatctc 240 cacttctact tttctggtag cttggccctg gcaaaatgag ccccacaatc tagaaagtag 300 gatgctaaac aaagttgaat caacatatct ttttagaaaa tatcaggtta gagaatactc 360 ctgaggacct gtttctaacc agagttgaca aatgtgaaaa atgcatcagc tagacagcaa 420 gtcatgtgaa cacagcccgg actgcaagtc aagggaaatg ggttctgggc ctggctttcc 480 aggtaaccaa aaccattntt caaaagcact tctggaatgc cacttggggg gaaagaaatg 540 ggaaagggga taaatcccat tnaatgcttg 570 <210> 639 <211> 563 <212> DNA <213> Homo sapiens <400> 639 gaagagtaaa acacattaaa aactttattg taagtatcaa catctaaatt tgcatcaatt 60 tgatacatcg ttgctcattt tgcagaacat aacagttgca cattgcaaga gtcaacttgc 120 ttcgggtctt ttcatgctca tggcggtcca cccctgcctt ccctctccct gacctgcatc 180 ctgtcctcca cagtctgccc tgcctcctgt cgccacaggt tgaagaccca agccctgagg 240 agaacctgct gccagggggc tggctggctg cgagccagga gggccaggca gttagccctg 300 ccacagggag gggcaggcaa gggatcgttt ctcctcttcc tgggctgagc ccatgccagg 360 ccagccacag agtgccctag tcagcccatg tggctccagg aagcccgctg ttgttcttct 420 ccatcccatt tcacccgcag cctantggct aactctggat actctgagca aaattaaccc 480 aagtttcatg gagaactcca gaaccttgaa ccantgcatg ggtatcccat tctttggtac 540 tagaagtagg aaaaggnctg cnn 563 <210> 640 <211> 558 <212> DNA <213> Homo sapiens <400> 640 agaaaaacca agtgtcttta ttcctcgatc gtttagtatg gcggtgggcg gcgcccgcgc 60 gggggagcct ggagcccagg gaatcgacct ggagggccag tggagggagc ggagggtgcg 120 aggatcggct cctccgcagg ccggccctgg aggggttctt gggggatcgc gccaggccaa 180 aagtctgcat gggcggcccc gagcctccct gagccggcgc gccccgggcg tggggagagg 240 ccgctctggg cgcggtgccg ctgcatggcc cctgccacct gctcctccaa cagatccaac 300 cgccccccca gctccccgct cacattggcc agcagccccc ccaactgctc tagtcggccc 360 cgggcagcag gcagccagtg gctcagcccc ccaggagccc caggccagct ctcctcctgc 420 tcctccgaag ggcccagggt ggagttgaag cggtccttca ggcgagacag gcnggaggcc 480 aaactggtgt aacctggggg gtggcctcct tgccccgcgg gtcttccaan ttttggcctt 540 gncggccact naaanttn 558 <210> 641 <211> 553 <212> DNA <213> Homo sapiens <400> 641 ggctcttaag ggtctttaat ggtttcattt tgtggccctt ccccccaacc ctggtgactg 60 tcccagcaag cagtcagtan aggtccccgg agttcagtgg gggcctggag atgtcggact 120 tgtgagggaa gggccactct ccccttgtaa cctctggtgg ctgctaggtg gaagctgcag 180 caagggggtc ccaagtgcag ggcctctggg tgctacacat ntcacagcca gggcggtctg 240 gggcattgat gaaggtgcag gaaggacagg accagctggg ctggagtgga ctgggcaggc 300 tggaggcagc tggctggggg cctggggtag ccccaatgat gggggaaaca agcgtccaag 360 ttccccgtcc atnttctggg ggtgctgagg gctaggtcct gtggctgggg cttctcgagg 420 agctgacagc aagtatagga aagcagggtc cccatctgcc gaaccccgta agaagcaaag 480 cttngcttaa gcaccacang caccgttcga tacccaccgt tcacgggtgg ngggaaacnn 540 actttnnaac act 553 <210> 642 <211> 206 <212> DNA <213> Homo sapiens <400> 642 ctggtcccac agctgagttt attatacttg ttttctttta caaaattaaa aacatctaaa 60 accaggccca agtggcagct tgagtccctc catttctgga aactgagaag gctccacctg 120 gcttgatatg gacacagggt gtggggtgga ggggaggagg tatggtgccc gaccnangag 180 gcaangggca tgggtggnaa nctgnn 206 <210> 643 <211> 309 <212> DNA <213> Homo sapiens <400> 643 aaaggtgcta cacaagagat atttattaat gttctgttgt atttacagtt ttaacatagc 60 aaaccaagat gaattaccac ttgggcagaa agcacatcat tctacattat aacccactgg 120 tttctgctaa cacattgtaa aagcaagtag tacagtatgt tagggatcat ctcaaaagtt 180 ccaagctact tctttctttg ctcctaagta cctaatcctc tccttactcc cagactttgg 240 cctaatcacc aggagacaaa aggaaaataa ggggggtggg gggtgggggg tggggtgann 300 ancgcnnnn 309 <210> 644 <211> 591 <212> DNA <213> Homo sapiens <400> 644 aaaatgtatg ctttcggcca agaagaagaa atgtgaattg ctttggcaat cgtcagtttg 60 gccgagtatt agtaatatga ttgggctaaa atttgatgtc aacatgcaac atgatttatt 120 atatgagtac actccagtga cttttcctac aggaaaaaaa agcattattg tttgcaatct 180 aataataaga taaaataaag ttagtatatt accttgatca atagttttca gttttaatga 240 gattttgcat tcttgatcaa gctcactaaa ttcagaacaa ataataggaa ctgtgctttc 300 tatcctcagg tagtattctt tcccatcctc tgatatagtg ctcaattcag gctgtagctt 360 aatgcctgca aaaaattctt ggctttcgat ggctacactt tgtcatgagg attctccaag 420 aaaaagacag aacgctgcag aatatcctgc tccaagtctg agatttatgc catcaagtct 480 aaaggagaga atgcctgact gnggctcttg gggcagctcc tctttgattc ttgagaagaa 540 gcctagacca gctntgggaa acccctgngt ttttgaacgg gacnatcaaa a 591 <210> 645 <211> 414 <212> DNA <213> Homo sapiens <400> 645 aaggtgcccg gtagctttaa tgagcacctt ttcctcactt tgtccctccc tctctactct 60 tccccttccc gtcttgacag gtccagcctg ccctagggct cttaaaccgc aggtatcaat 120 ccttctgtcc ccttagccgn tccaggcgcc tgcgaaggtc cgggggcacc ttggccccag 180 ctgccagcag ctcgcgcagc ctctgtttgg gagtcttggt gagcacgaaa ttgcagggga 240 aggggccctc ttcaaaggtg acccgacagt tccgtgtcac tgaatggtag ccctcggcac 300 tggcagtcac catgtagtcc cctggggtca gcagacgcca ataatccccg ncccacgccg 360 tggtcacgtc atggntaatc ccattcacgg naatgacngc gtnagnaatn ccaa 414 <210> 646 <211> 521 <212> DNA <213> Homo sapiens <400> 646 ggttttttaa aaaagtttaa tattattaca gtcaggaggc agcggctgga agatactcgg 60 ctctttcccc caagtccagg ttcagtgcat tggcccccac acagcacccc agcctcctgc 120 ctgggcaagg aggccctgcg ctcagtccag cttctccagc acagagggca catacaccag 180 gctgagctca ctgccaaagt tgcagacaat ggcagcgttg tccagcacca ggatctggcg 240 ggcaggctgg gcctcactgt tcttccccag gtagactgtc tgtaacaggt ccccgtagtt 300 taggtcccaa aaggagacac agccctggcc gccagtcacc agcaggttgt ctgagatgac 360 acccaagctt gcaccacagc ccaggtcctg ctgaatggag tagaacttga tgcctgtgct 420 gcggtcccag atgctgatga ngtcattcag gccactggtg atgacacang aaggtggtac 480 angtaaagga ngggacattc ccacngngag ccaacacatn g 521 <210> 647 <211> 582 <212> DNA <213> Homo sapiens <400> 647 gctcacactt agtttttatt agccacagtt tcccacagtt ttctacctcc taggaaatac 60 acagctcacc aagggcaccc agtcaccatt ctgtcctgct tgcatggctg acactgttgc 120 tcaccgaggg tgagcagatc tgcaaagtca cccagggcct ggtttcctca ggtacagaga 180 accccaaaga aagaagagcc agaacttaga gcccctttct tctccatatg ggataggaca 240 cccaagacaa atgacccatg catcatgaaa cagaggcagg gccctaagct gcccaagagg 300 cctgggcact tggagttcct gccaacagcc aggccactga accattgcct gtccaccctc 360 ccacagtggc taatccctgg cctagttgta aatgtctttt cagcgctgca cacttaatgc 420 agtcggatgc cttctgatta ctgggctctg agaccttcag ctgctgaggt gcaagaatca 480 agcatgggca tgaaaggcaa agggctacca caagcagcat tcgnttggct tcaccttggc 540 ttacgcgaac caacccaaca ngctgggacc tangaaagtt ct 582 <210> 648 <211> 565 <212> DNA <213> Homo sapiens <400> 648 caaaaaggca actttttttt ttttcttggc atcaatgaat atgcacttca gaaatctaca 60 gagaactttt ttcactttgt atttgttcca cagcattcta gccaggagtn caaaatagga 120 gctcttcaag cagcacatga agatggccca ggagccttca gccatccaga gcagcagagc 180 agcacctaaa tctccacaca cttcccagta taaccactaa gaacacacta gacccttggc 240 attaggggat ttatcatttc cagttctatt atctgggaat gactccaagg gtttgtgaca 300 agcttttgaa acgtaagtgc taagacgagt gtggacaagt cactgagcta atgaagaata 360 gacccactgt ctgcttggct ctgctatttt gtacctgtct tcacatgtgg ggaaacttca 420 taactggccc caaatcagag aaattccaaa ggactagaca atgtattgcc tgtgaactta 480 gaggcactgg gaatagtgca actgggaatn actagcttca tacataggcg gattggttcc 540 nggnccaaaa gcccanaana taaaa 565 <210> 649 <211> 552 <212> DNA <213> Homo sapiens <400> 649 aacaaaggtg tgtttatttc catatattgc tcattacatt tttcttgcca cagttttatc 60 taaagccagg tcaaaatctt tctctaaggt atttattaat agtgtatgtt cttcagatat 120 aaaatccctc tggtcaacat gcaacatttg aatatctatt ggcactgtac ctctatgaga 180 tatttatgac atttgttaat agtgaacctc aacctcctga ccccacatcc gaagttgggg 240 gcgatgtggg ggaacataca caaaattaca accacattac tggtcaagca ctttatagct 300 aaaatctatt gactttaaaa tagcattgta tgtgaattca gagttttaat gtattttgtg 360 gatcaaaagg aaagggtcaa aggctaagct gaacacggag ggcactaaat tagctaataa 420 ggcagctagt gcccctgttc ttgccccagc cctgcatatc actacatccg attctctcaa 480 atggtataaa ggaataatgg acttnaaact tcaggggttn ctgnaactgg gntnaantta 540 aagccgagtn tc 552 <210> 650 <211> 613 <212> DNA <213> Homo sapiens <400> 650 agaaaaacag cgtctgcctt tatttaagtc ccgtcccccg ccccaggtcc cgcccctggt 60 cccaccccgc gtcccggcgc gggagtcccc gggggatgga agtagctatc cagggctggc 120 tgaagggccc gggacacttg ctccgctctc tcttggagcc gcccggaacg cggggcgcga 180 ggctgctgca gggcccccag gaagtctggc agttgggagg gcagtgtgaa gacgggcacg 240 gtgcggaaaa gggcgggtac ggcgtccggg tggagcagcc tgtcgaagca ggcccccacg 300 tagcntgccg ggcgcccggc cctgcaagaa gtcgggcagc acgcagctga gcgaggcgcg 360 gaaggcgtcg tgcgggcccg tgcgccccgg gcccggacac cccatcctgt agccactcgc 420 ttgacaacgc caccggaccc ggagaagaaa accaggaccc caagccggcc ttctggnagg 480 gtttgggccc gttgccttga aaccaaccca nggcccttgg ncnctaagtt aacaacggtt 540 ccaagggtta cggcaccccc anggaanttg gcaaaggccc aacccagggg gccaccaggg 600 cttnaaaccc nnt 613 <210> 651 <211> 565 <212> DNA <213> Homo sapiens <400> 651 acatgaaaac atgtttattg cctgaataat aaaacttagc taaggagtta ttagaattac 60 gattccccct acttgaagta caagcttcca ataaacagac agacagaagc aaaaccccaa 120 atgagaaaga atacattggt aacctaaatc ataggcattt gtgggtatgt tcatacaatc 180 tacctatttc tttgtaattt actatagcac tgatgacaaa gcatagacat acaatgagaa 240 agagcaaatc agcatatcag tgtgactgtg caaccactac aaagcttggc cttcttaaat 300 gtggccactt taacttacac acgcccacag aggcatcaga aatctccctg caaacacgat 360 ttgcctatag ttttgtggca atactgttac atagaacaaa aacaactctc agaccatggt 420 taataaataa gagagaaaag aagttagaaa caactttcat gggttggcan gcatgccaag 480 gcagcacctt gaacccattt gaaaacaggc actgggatag cttttggagc ccaggantga 540 aggtttaagc ttnaangggc tttcc 565 <210> 652 <211> 527 <212> DNA <213> Homo sapiens <400> 652 agacttgaac acgtgtgggt catacacaca gacatgcacc ctcacgtgtg tatgttattg 60 acactggggt gtgcccgttt atgcatgtgc aggggtgaga gtgtgcactc atgtccaggt 120 gaactgggta cgcacactca gtcctgctgg cagggaagaa gccacagaca gaatcggcag 180 ggagtgtgac tatccacacg gggtcgagtt cacagcagcc ggctccgggg aatgtctgta 240 tgggcacacc tgtggggtag tgtgcacccc ctgggtcatg taaacagcag gtgggggagt 300 gtgtgccggg gatctgggca gccctcactg ccagctggca caagttctcg ggcaggctgt 360 gcanaatggc cttcaagttc tgtttgtcgg cccggatctc ggcganggca ctctcnaagc 420 cctggatctt gancttctgn ttgcttggaa ttgtgggctt caggttaaag gtccccggcg 480 aaatntggca catanggtgg cnttcacaat tttttttgca ngggcan 527 <210> 653 <211> 554 <212> DNA <213> Homo sapiens <400> 653 cttggaagta gggaggattt gaaagcttga aaatcaagaa tcaaaagaca gtgaatctag 60 aaggcatctg ggagcagaac agagattgaa gacgggtggg cacaggagaa agcgccacca 120 tcgatctcgg ctgctgccct ggaaatgtga ttttcttaat agctgagttc atggttgctt 180 gaggtcaggc ctggctattc atttccagcg atgtctgacc agagaggact catcattgac 240 gacctcaggg tcacgggggc gacgctgaca ccggaacggc agcagcagca ggacgattaa 300 gacaaggagg atggctccac agacgctcat gagcgcatag gacacaatcc acaaaatggg 360 ctcgctcaaa gactgagcgg ggacacagtt gctggctaca tcctctgttg agaaaggccc 420 ggaaatttca gacactgcag cacctgcaat ttctgcacag gggctcgctt gcgaacccac 480 cctnttctgg gcttttgtcn aanatgacgt aaaagccctc annaccgggg caccgatccc 540 agcgcatttt ggat 554 <210> 654 <211> 462 <212> DNA <213> Homo sapiens <400> 654 gcctggaaac tggagagctc cctctgccag ccccagggtc tgccgagttc acttgacgag 60 gccgggaact gcaggggcgg gctggggctc actcagcatt tatttcatac agctgcttaa 120 aaagctagtt ttaaaataga gatcattata tatatacata tatatttata tatataaaat 180 atataaagag gaattgagaa gtgccacccc aaagaaaaag ctatgtttta taaatatttc 240 tgtagcttcc acatcccaaa ggaagaaaaa gcaaaaaaca aaagaaaaca tttacaaccc 300 aagctagtga ttccatgtgg tgggcccagc aggctcagac cccagggtgg gccagggggt 360 cccgcagaac attctgaana agcgggcaga cccttccgga ggctggctnt gnggcctgna 420 anggcaagct gtttaagctn ancgatccaa gcccggtctt aa 462 <210> 655 <211> 552 <212> DNA <213> Homo sapiens <400> 655 gaaaaccaac caggaacatt tattaaaaaa ctaagcaagt tatccccaag agggtgaagc 60 accgctggct ggttctgaca ttcgattcag gctgaaggca cggcaactcc tccagccctt 120 gctgggaaat gtcctaccca ggccacgggc agtgccccag tgcagctggg tcccctaaaa 180 gcccccaaac acatgatccc accaaaggct tgaacagagc aacttcatca agcaggcagg 240 gaccacacct gagacacaag ggcaaggagg taaagcacag gggactggga gtgggccagg 300 gacacccagc ccccgtctcc aactggcgcc ccctccaggg gggctaacat gtggcgtggg 360 gccaccagga cctgtgcttg cccctggtgg cggaagaact acccttcctc ttgggtggtg 420 ggggggatgt tgtccgcaca cagcttanac gaccgagggt ncaggaagaa tcaaactcag 480 tcaaccattc ttttaaccca acttggaagt ntgtgaaggc cttggnacac aagtgcttaa 540 ataaaacact tg 552 <210> 656 <211> 553 <212> DNA <213> Homo sapiens <400> 656 aagttgaaca gaacatttta tttctcagca attctatgcg tacaaattaa acatgagatg 60 aatagagact ttattgagaa agcaagagaa aattcctatc aaccccaagg aggactcaaa 120 gtgaggctgg aagaggactt agaagagtat gaaagtactc taagatttta tctaagttgc 180 cttttctggg tgggaaagtt taaccttagt gactaaggac atcacatatg aagaatgttt 240 aagttggagg tggcagcgtg aattgcaaac agggcctgct tcagtgactg tgtgcctgta 300 gtcccagcta ctcgggagtc tgtgtgaggc caggggtgcc agcgcaccag ctagatgctc 360 tgtaacttct aggccccatt ttcccctctg aaaataagag ggttggttca aacgatctct 420 ggggccttag catctcaaat cctgggggat cctnctactt accccttaga gagccttact 480 gggaagtcag tcattaatga tggtggcccg tantttgcaa gtgggtaaaa gcctttttac 540 cnttaataat ccn 553 <210> 657 <211> 525 <212> DNA <213> Homo sapiens <400> 657 gagacagagt cttgctctgt cacccaggct ggagtgctgt ggctggatct cagctcactg 60 caagctccgc ctcccaggtt cacaccattc tcctgcctca gcctcccgag tagctgggac 120 tacaggcacc cgccaccacg cccggctaat tttttgtatt tttagtggaa acagggtttc 180 accgtgttag ccaggatggt cttgatctcc tgacctcatg atccgcctgc ctcggtctcc 240 caaagtgctg gattacaggc gtgagccacc tcgcccagcc cctaatcttg gattcttaag 300 cccaggctct ttgtagctta ttctccagta tgctttcctc caagcttcca gttctgggct 360 tccttaatat gcaattccaa atgtctggat tttccagcta gagatgggga gctcttaact 420 ttctggctcc tggcccaggc tccttaggat tcaggactgg gtnccaggca ngaaaaaaac 480 ggcaggtgcc aacngggtcc ctggngntgc cganggcaaa ncaag 525 <210> 658 <211> 546 <212> DNA <213> Homo sapiens <400> 658 gagcagtgga ttttcctttt aatgcaaaat gttgcaatac aaaacaatgt ggagaaagtc 60 ctgttcctca ggacactgaa gggaggagtg aggaagagag gacagagctg gacgtctcct 120 cctatttctc cctccccaag tcactctgag gggaagaaca ctgctgcctg ctccctgggc 180 ctgcccgcat acaaggttag agccctgggt ctggggcatc cttagcctga aatttgttga 240 catggggcag gagagcagga gggaacattg agggttttga ctnttcgggc tctaaaagga 300 ttactcagga tctggagttc cgtatgaaac aaaggagctg aaagaatttg attgccattg 360 gctaaaaata tagaggattt nagccacaac tggcccacat ttgaagaatg aggaacaaga 420 aatttantgg ggatataata taaatgtatg ggagtgagaa agatgcaaaa gacaaggcta 480 gcttctcaaa cctnctnctc ttcttnctca tnttcacttt atagacaatc tnggnagcct 540 tnaatc 546 <210> 659 <211> 565 <212> DNA <213> Homo sapiens <400> 659 aaaaaatcac atagaacttt attaaataaa ccagtagaaa ggctcctatt tacatccagg 60 ttgtcagttt aagctcaagt aatatgcaag gcacaattct tcctttctcc agctttagaa 120 aaatcaacca catggcccag ccctgaagga ctgaagggag cttgtgcggg atcccgtcat 180 cctggactct ccacacagcg tccacgcatg gatggccatg ggcatgagtc tctggatctc 240 cctgagggtg gcccagcctc ggcctggagc acaggggcct gtgatctgag aatctcagat 300 ccagaatcag gagctgggaa gagaggactt ttccaagggt ctcctccccc aggccctggg 360 gagtcccttc tggatgggca ggccctgggc tggtggccgc ctccatcatt ggcccaagcc 420 gggctctagg gcccggctgg gaactgtctg gggccctgcg cctgataagc tgncatgaaa 480 gtgggccgct tttacactgc angcngtggc tcaaaactgc ttanggtctg gaatgggcca 540 ngaacnggag ggccaaatga ccttg 565 <210> 660 <211> 488 <212> DNA <213> Homo sapiens <400> 660 aaacaaaaca aaataccagn ggctagcttt tctgtaacat cctttggatt tggttaaaaa 60 aagaaagaaa agtctacaga acaggatcac tgaatgccac tttagcccca cttcctgcag 120 gctctgnttt aattagcgtc aaacaggtta ctgaacattt nttcagctgc ggaaagaagt 180 tctgaatggg tgacagctgc ccggagnggc tntacctggt tccattttac ccctcatcag 240 tcagngnggt ttcttgccaa acaacaccta acgttttacc ccttattcct gcagggaggc 300 gggccctgtg gctgactgga cacagagaaa aaaaagaaaa actngcacaa acatagagac 360 tatacacgga gggagagagg agtccctctt tctgnttcct tcaagaactt gntaaataat 420 aacctcnaag tgcaacaatg cacaaatgtt ngccacaggt tantctngag ggacttggta 480 ttacnggg 488 <210> 661 <211> 539 <212> DNA <213> Homo sapiens <400> 661 gtttttgtgt gtcatcctca gaccagccat ttgcctcttc caaaaagctg gggctaagca 60 tgtgggtggt tcaagagggg cagcccccag gccccaggct gggccgcggt accagtggca 120 ggtccccctg ggtctcagga gcttagcttc tacggagctc aggtgtcatt tatggggttg 180 ccagagcaag ctgttaaagg gcgaatttgg taagactgag ctcanagacc tggtgggagg 240 gcaaggactg gcgggcacag caggaggaga ttagaggagg gtccacctga atctttgcag 300 caggcacaga gcttctggct gcatctcaga agggggcaga cgcacaggcc agggaacacg 360 gggctctagg ctgtggctcc gaatgtccct ggtgactgga aagcctgang ggaggctgga 420 actgatcagg atcccgtggc ttgtgagaca gaatgagctc tttcttnctg aaaagggccc 480 aaggganaag aanaagagcn gacattacac tggtccttca tccttgccgn ggnaaaaan 539 <210> 662 <211> 470 <212> DNA <213> Homo sapiens <400> 662 cgcnagccac ggccacnctt tattgcttaa gacncacaca gaacacagag gaacaaacaa 60 ggnggaaagg gcnccacaca cagcccaaac caggcaggag cggcccagcc gccggaanan 120 acgttccttg caaggcaggg cccctgntgg acagcacgcc ccctgggcna cagggtcagg 180 gaccccagna ctgcacagnt gcaaacttgn tgggaacctg ggacaggtga cacgcccact 240 ttcgcctgng gcccagggcc ttccaccttt gcatccagcc ntgcacccac catttcccca 300 cagggtacag gggcagcctt ccttgatcca cagccaaccc ttctcctgct gtctctggct 360 gtcagtgana cccctntgga aagggcagaa ncaggcaagc caggcanaag ggggcccngg 420 gtccactacc tgggtaggaa tgaccaaang gcgggcaaaa gcccttntnc 470 <210> 663 <211> 472 <212> DNA <213> Homo sapiens <400> 663 acaaagacat ttattttccc caaaatatac ccccagttta caaaatccct ccgagtccca 60 catttaaatt agaagtcctc acatcttcca ttcctggggc agggagagat gacatccgga 120 aggcatcaga acgtctgaag tctcactcta ccagaggcca ggagctggcc agaggcaagc 180 caggaaaaga ctgccccagc cccagaatag caccatggtg ggggtggggg gcagtcccct 240 cggtgtcccc aaagcattcc tggccctgcc ctgccccagg ctctgccttt tctgctgcta 300 tgaaaggtcc agagggcctt ggtgcctgcc cacctgccca cacctggaca gacattttgg 360 acaccaccag attctntagc cgtggcnagg ggctatgtcc ctctntcagg nttcgnccca 420 accccatgct ctgggtaaga attatgggtg ggatgggggt naggtnttcc ag 472 <210> 664 <211> 548 <212> DNA <213> Homo sapiens <400> 664 catgctttaa gattgagatt ttattactat gaagggcaca tagtatcttt attgaaagaa 60 acatttattg aaacattata taaaatgttg actaaattct gtagtgtatt tggagtgaac 120 atcatcttga atagagattt taaaatttca taatcttaac ctccgacgat atgattatac 180 ttgtttaaaa agaacattat atccagatat aaacttaaca aatgaaatat tacaaaatat 240 gaacatagat agttttgttt cccattataa ttcccagcat tttcaccctg tcctgttcat 300 acgagtcaat tctcttcttc aattcctgtc ccatcagccg tctgctgaaa aacactgctt 360 tgtcttggct aaggctgcac aagttcagtc tcgcactggc tcagcctccc ctttcagcga 420 caccatttcc ctaccagggt acaagctggt ttccctggtg ctctaggtgg agctggattt 480 ggcattcgtt ccccatccct agtgctcttt aagctggtnc ctgaagtcac aagaaacnct 540 tttggttg 548 <210> 665 <211> 600 <212> DNA <213> Homo sapiens <400> 665 cttttttttt tttgagatgg acgtctcact ctgtcgtcca ggctggagtg cagnggtgtg 60 atcacagctc agtgcagnga actcctggac tcaagccacc ctcccacttc agcctcccaa 120 gtagccggga caacaagcac aagccaccac acctggctaa tttttaaaat attttgtagc 180 gatgggggcc tccctgtgtt tcccaggctg atctcgacct ccgaggctca atcgataccc 240 ccacctcggt ctcccaaagt gttgggatta caggcttgac gactgtgccc ggcctgggct 300 ttttggaatg agtcttcctg gtcccgacag ttctcctgca tgtccttgtg gtggccagtc 360 tctgttcttt gatgacgaat ttgctttctg agtagagtct ggtcacctgg agctggtttg 420 gtggaataaa ggacaatggg tttctaggat gtagctggga gaatcagctg tgagtactct 480 aatatgagat aagtttctta tgcaggccca attggtcctg aagtccttct tnaagaggcg 540 aatcttgaaa cctaccccaa gtgacgtgag cntnaggaga atgcnccttg cngcaancnt 600 <210> 666 <211> 586 <212> DNA <213> Homo sapiens <400> 666 gccttagaca cagaagcttt atttttctat aaaattattc ccgagagaaa ttttctttta 60 aatgcccaaa gtaaataact tatatccctt cttgaaaaca tccccaaaga tagtctgtca 120 gaaatccttc ggtcaagcag gtcagctggc tcccatggcc cttggggtgg cctgactctg 180 tcactattcc taaaaccttc taggacatct gctccaggaa gaactttcaa caccaaaatt 240 catctcaatt ttacagatgg gaaaagtgat tctgagacca gaccagggtc aggccaaggt 300 catccagcat cagtggctgg gctgagactg ggcccaggga accctgtctg ctcctctttt 360 tcccagagct gtgagttctc tagccaaggc tgcactcttg agggagagcc aggaagcata 420 gctgaggcca tgacaacctc actcttcacc tgaaaattta acccgtggca nangatccag 480 gcacatatag gcttcggagc ccaacaggcc taaagaaata gttgaacact ttcttcccca 540 gncatntncc tggagtcaag gtttgccang nttaaatgca aggnan 586 <210> 667 <211> 558 <212> DNA <213> Homo sapiens <400> 667 ggattgaata atttattccc tgtattatta tagtaacagg agcaaataca taaattttta 60 ttaataaaac aaaaaagatg aaaaacagaa gcaacaaatg aagacatcca tactgcccat 120 aacacatcag ccatatgatc agaaaaccca tttctaaaga gcaatggttg ctggtgtcac 180 agagttttat tgcattcatc gggggaaagg gagatggttg gaatgaaaaa gatccatcag 240 tcttctgaca ggaagatgtt atatgggggc tccaacccct aactgggtac tcctcttgct 300 accacctttg gagcagaaga tgaaggggag agggagcttc tccctatggc ctcatggctt 360 cttgtgagac agatcagtcc agccagatac agagcaaagc agctttgcat caccacaggc 420 cagttgctga tgcccagctt tatgtctaaa aaaaaaaaaa gtggaagcct caagggggat 480 ggaggattgc cagaaaaatg ggtgccctgg gcccanaggc ntttnnggan aaggaaacca 540 tgnttttaat aggggtnt 558 <210> 668 <211> 567 <212> DNA <213> Homo sapiens <400> 668 gctaggtgat tacaacagct gatttttatt tttcttcttg attctcttct acagtttcca 60 aattctctac aatgaacatg tacttctttt taatatcaaa agacaaaaga attggtacgt 120 aaaaagaaca tccttcccat cttcaaggtc aagattgaac gctgactcct gcaggaagtc 180 ttccaggatt cccaggcagg aatgatggct ccctgtccct gtagctccag gagttcttgc 240 ttcacgcacg cctcacatac cagactgaat gttggcagga ggagtgacca ggtcggtcat 300 ctgtgtccct accacctaca acaggccagc aatctacccg ngtgtgtttg ttggacagaa 360 ttaaccatga tgggcggncg aaggcccctg gagctatttg ggggcttgga gagaacctct 420 tangaagaag tggtcangcc ctaggccagg gcaccagaag gaggcaagct taagnccttg 480 gaatggtggg aatggaaacc canacgggac tggcatgggn ccacaagttn ttaccccaag 540 anggcttcag ganaagctta aggnccc 567 <210> 669 <211> 561 <212> DNA <213> Homo sapiens <400> 669 gatttaagaa agaaatttta ctgtgtcttt catacacaaa agctgattaa caatggttaa 60 aaaaacacta ctccactttt tcacaggtgt acaaaaggaa atataatgga attacattca 120 acaataaagc ttaaagttca ctctaggtaa tagttgcatt aacattcaca tacacaagca 180 cagagtaagt atatttcagg agtcttagca tagcatacag catacatatg ggagattgat 240 ttcaggtaac atcataggtg ttagtaagat tagcaattca gagtgttata gaaaaggaaa 300 actaaaccaa agagaaggtg taggctagca caccaagaca agtcacagaa ttagtagatt 360 gaaaaatccg ctcactgtat gagaaaacaa tatttttctt caatttttgg gtcttgatat 420 atagttggtt agagaaaggt gtgtatcaaa gtgcccataa ttggttctta gaaaagagag 480 agagagagag aaaggaggga ccttttantt aagnattcct gccaagaggc agccccaagt 540 ggcccggaaa gagtaaactt g 561 <210> 670 <211> 569 <212> DNA <213> Homo sapiens <400> 670 ggctttttaa ccatcgtctc tttatttaca gctcaagagc acatgcaaca tgacatcatg 60 aaactacaag ggcgtggcac ttccccctcc ccctgccgct ccccaacttt aaaaaggaag 120 tacagcaccc taggaagttg cctaagagtc agaaaaccct acactgaggg tcccaggccg 180 aggtgctcca ttcattgcct ccaaaaataa agaccagttg cagcccagga ggcttgggcc 240 tcanagcctg ggagtttgtc attgctggta attagctacg caaaacaggt ctcggatttg 300 ccagctcaca cctgaataca aatagcccga attatccgaa tgtccctgac caccccacat 360 ttctgntttc cccgtcgtat cctagacctg ngattctcaa atttgatcgt gcccaagaat 420 gacctggaga acttgtgaaa agcccaatgg nttgggcccc accccagaga ttttggttaa 480 taggcttggg tggtgggggc ccaanaatct gnattctttt tgggnttttg gctttttttg 540 gacaagggnt tgctggattg cctaactgg 569 <210> 671 <211> 553 <212> DNA <213> Homo sapiens <400> 671 gattcttaac atatttaatg aaactcgagc ttcataaacc agtgaaatgc ctacccctat 60 ggagacgggg agctggtcat gggacccagg tgcctggagg acatcccagt ggctttgaag 120 gctccagcca gtcaagacgg tcaatattag cccttctgcc aacatctggc aatgtgaggc 180 tggggtggac gttggcctga tgttgccagg agtaggatgc tgatgctgcc agagagtagg 240 tgggctccaa accccaggct tctcacttgc ttactaagca cagcagtctg aagcttggga 300 cctggcagtg cgtctttgga gaaggcaaaa aagccacagc agcaacactt aggagcaaga 360 cccttcccgc tctccaccct atttcctccc ctgaagaaga gcaacagctc aagctctagc 420 atggcacaga acgctaggtt gggccaggca agcagccatg gtggggccag gtgaagcaat 480 gtgggtctta acaaggaacc ctnttgaagt ggcaatggct tccaaggctt gttgacaact 540 ggacaccana att 553 <210> 672 <211> 490 <212> DNA <213> Homo sapiens <400> 672 cctgaaatgt aaattggttt taatatattt aagagcacac agaantcttg atttataaaa 60 aaataaatnt atnacatgac aaatttactg atgatccngg agctctgagg tcaaactctt 120 taaatgatca gtgaaaacat aaaacatcca tgatctgtta acacacacag gagcatattc 180 cagttgtaaa aaacaaattc cttgaaggct cagaacgaac aaaaatcagt ctttatggca 240 gaaagcacat ccaaagctag gcaatgaagt tcagcctggg ccacgtgaac ctttnaccag 300 ccagcctata acctatggag ccaggacagg aaagcatgat ccttcactca tgaccgccac 360 ccanggcttc cagacactgn gaatggaaag aagtccttan aaggttccca agccctgntg 420 gcctcattna accccgggaa gggattggtt ttggccctta ncggggtntt gncctaaatt 480 tgagagccng 490 <210> 673 <211> 399 <212> DNA <213> Homo sapiens <400> 673 cttttttttt tttttataga aatcaccctg gttnattntt ttcaacaaag gaaaaanaaa 60 catggntcaa taattcagca tttgggactc tggcnagtac tgtctgcatt gttcaaaata 120 agtgttcctg gctgtgagct ctgcaacaca tactgatggc ccangaacct tcttccatgg 180 ntctaataaa acaaaggacc cacacatgga ggttacgtga gtcaacaaaa gatgctctat 240 cacaatgtgc gtaaaaagca agtctttnaa aaatatccag atctctaaag gaatacaaac 300 actnctattt ggttttgttn ttgttcatct tcagtattat attntagttg ttgangaaaa 360 atttttttac tggaaangga acggngttat attgacntt 399 <210> 674 <211> 530 <212> DNA <213> Homo sapiens <400> 674 catttgtcac ttgctttatg caaacattcg agtgtacctc tttcaccaca gggctagaga 60 tggtctactc tgtacataca tttcacaaca aagaaaaatt ctgtcattcc ccaactctat 120 gaccaaggaa aacttttagg atttctttaa tttgtagcag agacacagtg gcctagccaa 180 tcggcagtgc tatacacaca gtatgccagt ttcccacccc taccctcttt ctcctttttt 240 aaagcttcaa aggttagatc aataaaattt aaaatttcct catttaagga gaaatataat 300 gacccacatg ttaatttata ttaaaaacta aaaataaata atggggttct taaacaagga 360 catctttaac taggttatga ttagaccagc ctgtgggtga aatgagagat tatctcttct 420 ccctggaaat gcttcaaggc tcagacaatc agtaggtttt aaaaaggtcc aacttacaca 480 tttnaggtgg aaagtttagg caanggcacc aaccagaacc ttggtntgcc 530 <210> 675 <211> 543 <212> DNA <213> Homo sapiens <400> 675 cattttctcc attttatttg tcaatataaa aatactcaaa tatttacaac aaataaatac 60 gcggggacac aataagttac actgttagga gccctcctcc tagggctgga agagagtatg 120 ccattgtcca cagcaggccc accctctccc ttctctcccc tcacacagcc tttcccagcc 180 ctgtacagga agaaggcaag tataaaatac cactgaaccc cggggccaag tgggaggccc 240 cacccaccct tccccccaaa cacacaggag gctccatctc cctcccccca ccctgaaaac 300 attcacagcc ctaggagcag gactaggccc accccaagcc ctgcactccc tctgaagggg 360 cacagcaccc tgtccacccc acctccatat gtacatcgct gcccgacact tggggcagng 420 ggggtaggag agacaaagtg atacgacccc ttcccttcat agcttcaatg acttaccaag 480 gaggacccan gccangggga gaacttgaca gaaacnggaa ggntttgnca naagcgcgca 540 ngc 543 <210> 676 <211> 541 <212> DNA <213> Homo sapiens <400> 676 gagatggagt ctcgctctgt tgccaggctg gagtgcagtg gtgtgatctt ggctcactga 60 aacctccatc tcctgagttc aagtgattct cgtgcctcan cctcctgtgt agctgggatt 120 acaggctcct gccaccacac ccagctaatt tttatatttt tagtaganac ggggtttcac 180 catgttggcc aggatggtct cgaactcctg acctcgtgat ctgcctgcct tggcctccca 240 aagtgctgag attacaggcg taagtcactg cgcctggcca gggagtcctt ttctaactga 300 gcctattttt ctcttaggtc aaatggaata agtgacaaac tctaatttgt agaaacattt 360 taggccatgt ataagttaca ctgattttag cactaagcta tatttttatc acagatgggt 420 caccttaaaa gaaaactaag gagatggaat gaatctggaa actttctnaa tccaggnagt 480 tnacaccctt actcaaccgn aantttaaac cnggatttaa aagaaccttt tttttganac 540 a 541 <210> 677 <211> 541 <212> DNA <213> Homo sapiens <400> 677 agaaaaaaag aaaaaagttt aatagcgata tagaaaattg agcacctata aaactatatg 60 gtgggctctg ggttacattg agcttaagta gaccaagtat ctatcccacc taaattatca 120 gcaactccag gccatgaccc agtgtcccat tctccttcac ggtttgctgg tgtgtagcct 180 cctggataca ggcaatgtat atagatcgca gagaatgtcc gttctggcct cttccttgga 240 agggtctaaa aacagacctt aaggagctaa gtgacttccc caaagcccac agctccagtg 300 ccactgctga cttttgggtg ggggtgggat cagttaaaga ggaaagcttt cagtactgtc 360 agcacataca cctgccaatt aaggggctga atagagttca tctctaggag caggaccttc 420 acccccaccc ttcaccccag aagccatgtc atgctggttc accaggatct tgcctgaagg 480 taaaatggga aagaaccgnt tccaactttg gtgggagnct tattaacccc nccttgaagn 540 t 541 <210> 678 <211> 510 <212> DNA <213> Homo sapiens <400> 678 gngtgtaaag ggtttttatt ggagagcctg tggcgctgaa gtgccaccaa ggatttggaa 60 ggtcactttc agcagccgcc atttctgcca ggaccagtgg caagcacctg gcagatggag 120 cccgggtgtt tctgcgtaag gcagaggaat ccagcttttc catgagattc agctgcagtt 180 gtcgaaaacc ctgtgtgagc cagcagttcc agttcaaagg ttgagggggc gaacagctgc 240 naggnggcca ggctcccgtg agtcaccact caggcctgag tacaccgtgg agaggagaga 300 taaagcagcc acggntgttc tgttgccagt cccacccctn tggcaaacag atgggggaaa 360 acagggaagg aaagcaacaa agaaggtgaa atgcanggag cagagactnc acgcaggccc 420 cccgtggctn gcaataccat cctgctgggc ccgntgtgca cctttaccag ggnttccacg 480 ggcttctggt nttttcctgt aaaggcnaan 510 <210> 679 <211> 510 <212> DNA <213> Homo sapiens <400> 679 gcataggcat tactagggac ataaatggga gactggcata gaaagtggtg aggagccgaa 60 gccaaggaat tgctttaaac acaagatgaa aatactctgt tctgtccaaa gcatcaccta 120 atggtgtgag gcatctcact tagctgtgga gaagtccttg gaattagatc tcagaaagac 180 agctttaaga cagtaaaacc ttttggcaat gggctaattg ccttaaaaga agagttctac 240 ctgaaagacc ttgcaggtgg agaaattgtc ctacaaagat tcttggatat gttagtggag 300 ataactgaca tgggtagctg tgggtcaacc aggaactgtc aacaacctga tctctgcaaa 360 accaggatgg ccagttaatg gtttattcag ttctctgatg gtcacaaatg taattttatt 420 tanccttgtg gaggttctgc aacaaatgta attttaaagg aattnggagc cngaangata 480 aatcaactcc tttaactacn tgacanggcn 510

【図面の簡単な説明】

【図１】pME18SFL3とpUC19FL3のベクターのマップ

【図２】遺伝子発現解析の再現性を示すグラフ。縦軸と
横軸はそれぞれ異なる実験によって得られた発現強度を
示している。

【図３】遺伝子発現解析における検出感度を示すグラ
フ。縦軸は発現強度を、横軸はプローブの濃度（μg/m
l）を示す。

【図４】RT-PCR法を用いた未分化、及びレチノイン酸処
理後1,3,5 週後でのNT2細胞におけるPSECクローンの経
時的発現変化の解析結果を示す写真。PSECクローン名、
遺伝子名の下に記載されているのは、PCR反応条件（ア
ニーリング温度と４種のサイクル数）である。RA(-)は
未分化NT2細胞、RA(+)はレチノイン酸添加NT2細胞を示
しており、各サンプルにつき４種の異なるサイクル数
（前出）でのPCR結果が表されている。

【図５】RT-PCR法を用いた未分化NT2細胞、及びNT2ニュ
ーロンにおけるPSECクローンの発現変化の解析結果を示
す写真。PCR反応条件のアニーリング温度は図４と同
一。サイクル数は各サンプルにつき、記載の３種の異な
るサイクル数で行った。

【図６】PSECクローン由来のRT-PCR増幅産物の経時変化
のグラフ。PSECクローン名、遺伝子名の横に記載されて
いるのは、グラフに使用したデータのPCR反応条件（サ
イクル数）である。RA(-)は未分化NT2細胞、RA(+)はレ
チノイン酸添加NT2細胞を示している。各点は３回の独
立して行われたデータの平均値を、同様に処理したβア
クチン発現量で補正し、最終的にレチノイン酸添加1週
間後のNT2細胞における産物量を１として相対比として
表した。

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.⁷ 識別記号 ＦＩ テーマコート゛(参考） Ｃ１２Ｎ 1/21 Ｃ１２Ｐ 21/02 Ｃ 5/10 Ｃ１２Ｑ 1/68 Ａ Ｃ１２Ｐ 21/02 Ｃ１２Ｐ 21/08 Ｃ１２Ｑ 1/68 Ｃ１２Ｎ 15/00 ＺＮＡＡ // Ｃ１２Ｐ 21/08 5/00 Ａ (72)発明者 林 浩司 千葉県市原市有秋台西１−９−446 Ｆターム(参考） 4B024 AA01 AA11 BA80 CA04 DA01 DA02 DA05 DA11 EA04 GA11 HA14 HA20 4B063 QA01 QA13 QA18 QQ02 QQ42 QQ53 QR08 QR32 QR55 QR62 QS02 QS25 QS34 4B064 AG01 CA19 CC24 DA01 DA13 4B065 AA01X AA57X AA87X AA93Y AB01 AC14 BA01 CA24 CA44 CA46 4H045 AA10 AA11 AA20 BA10 CA40 DA76 EA20 EA50 FA72 FA74

Claims (23)

【特許請求の範囲】
1. 【請求項１】下記（ａ）から（ｆ）のいずれかに記載の
   ポリヌクレオチド。 （ａ）次の配列番号のいずれかに記載された塩基配列の
   蛋白質コード領域を含むポリヌクレオチド。 配列番号：１、配列番号：３、配列番号：５、配列番
   号：７、配列番号：９、配列番号：１１、配列番号：１
   ３、配列番号：１５、配列番号：１７、配列番号：１
   ９、配列番号：２１、配列番号：２３、配列番号：２
   ５、配列番号：２７、配列番号：２９、配列番号：３
   １、配列番号：３３、配列番号：３５、配列番号：３
   ７、配列番号：３９、配列番号：４１、配列番号：４
   ３、配列番号：４５、配列番号：４７、配列番号：４
   ９、配列番号：５１、配列番号：５３、配列番号：５
   ５、配列番号：５７、配列番号：５９、配列番号：６
   １、配列番号：６３、配列番号：６５、配列番号：６
   ７、配列番号：６９、配列番号：７１、配列番号：７
   ３、配列番号：７５、配列番号：７７、配列番号：７
   ９、配列番号：８１、配列番号：８３、配列番号：８
   ５、配列番号：８７、配列番号：８９、配列番号：９
   １、配列番号：９３、配列番号：９５、配列番号：９
   ７、配列番号：９９、配列番号：１０１、配列番号：１
   ０３、配列番号：１０５、配列番号：１０７、配列番
   号：１０９、配列番号：１１１、配列番号：１１３、配
   列番号：１１５、配列番号：１１７、配列番号：１１
   ９、配列番号：１２１、配列番号：１２３、配列番号：
   １２５、配列番号：１２７、配列番号：１２９、配列番
   号：１３１、配列番号：１３３、配列番号：１３５、配
   列番号：１３７、配列番号：１３９、配列番号：１４
   １、配列番号：１４３、配列番号：１４５、配列番号：
   １４７、配列番号：１４９、配列番号：１５１、配列番
   号：１５３、配列番号：１５５、配列番号：１５７、配
   列番号：１５９、配列番号：１６１、配列番号：１６
   ３、配列番号：１６５、配列番号：１６７、配列番号：
   １６９、配列番号：１７１、配列番号：１７３、配列番
   号：１７５、配列番号：１７７、配列番号：１７９、配
   列番号：１８１、配列番号：１８３、配列番号：１８
   ５、配列番号：１８７、配列番号：１８９、配列番号：
   １９１、配列番号：１９３、配列番号：１９５、配列番
   号：１９７、配列番号：１９９、配列番号：２０１、配
   列番号：２０３、配列番号：２０５、配列番号：２０
   ７、配列番号：２０９、配列番号：２１１、配列番号：
   ２１３、配列番号：２１５、配列番号：２１７、配列番
   号：２１９、配列番号：２２１、配列番号：２２３、配
   列番号：２２５、配列番号：２２７、配列番号：２２
   ９、配列番号：２３１、配列番号：２３３、配列番号：
   ２３５、配列番号：２３７、配列番号：２３９、配列番
   号：２４１、配列番号：２４３、配列番号：２４５、配
   列番号：２４７、配列番号：２４９、配列番号：２５
   １、配列番号：２５３、配列番号：２５５、配列番号：
   ２５７、配列番号：２５９、配列番号：２６１、配列番
   号：２６３、配列番号：２６５、配列番号：２６７、配
   列番号：２６９、配列番号：２７１、配列番号：２７
   ３、配列番号：２７５、配列番号：２７７、配列番号：
   ２７９、配列番号：２８１、配列番号：２８３、配列番
   号：２８５、配列番号：２８７、配列番号：２８９、配
   列番号：２９１、配列番号：２９３、配列番号：２９
   ５、配列番号：２９７、配列番号：２９９、配列番号：
   ３０１、配列番号：３０３、配列番号：３０５、配列番
   号：３０７、配列番号：３０９、配列番号：３１１、配
   列番号：３１３、配列番号：３１５、配列番号：３１
   ７、配列番号：３１９、配列番号：３２１、配列番号：
   ３２３、配列番号：３２５、配列番号：３２７、配列番
   号：３２９、配列番号：３３１、配列番号：３３３、配
   列番号：３３５、配列番号：３４１、配列番号：３４
   ３、配列番号：３４５、配列番号：３４７、および配列
   番号：３４９ （ｂ）次の配列番号のいずれかに記載のアミノ酸配列か
   らなる蛋白質をコードする塩基配列を含むポリヌクレオ
   チド。 配列番号：２、配列番号：４、配列番号：６、配列番
   号：８、配列番号：１０、配列番号：１２、配列番号：
   １４、配列番号：１６、配列番号：１８、配列番号：２
   ０、配列番号：２２、配列番号：２４、配列番号：２
   ６、配列番号：２８、配列番号：３０、配列番号：３
   ２、配列番号：３４、配列番号：３６、配列番号：３
   ８、配列番号：４０、配列番号：４２、配列番号：４
   ４、配列番号：４６、配列番号：４８、配列番号：５
   ０、配列番号：５２、配列番号：５４、配列番号：５
   ６、配列番号：５８、配列番号：６０、配列番号：６
   ２、配列番号：６４、配列番号：６６、配列番号：６
   ８、配列番号：７０、配列番号：７２、配列番号：７
   ４、配列番号：７６、配列番号：７８、配列番号：８
   ０、配列番号：８２、配列番号：８４、配列番号：８
   ６、配列番号：８８、配列番号：９０、配列番号：９
   ２、配列番号：９４、配列番号：９６、配列番号：９
   ８、配列番号：１００、配列番号：１０２、配列番号：
   １０４、配列番号：１０６、配列番号：１０８、配列番
   号：１１０、配列番号：１１２、配列番号：１１４、配
   列番号：１１６、配列番号：１１８、配列番号：１２
   ０、配列番号：１２２、配列番号：１２４、配列番号：
   １２６、配列番号：１２８、配列番号：１３０、配列番
   号：１３２、配列番号：１３４、配列番号：１３６、配
   列番号：１３８、配列番号：１４０、配列番号：１４
   ２、配列番号：１４４、配列番号：１４６、配列番号：
   １４８、配列番号：１５０、配列番号：１５２、配列番
   号：１５４、配列番号：１５６、配列番号：１５８、配
   列番号：１６０、配列番号：１６２、配列番号：１６
   ４、配列番号：１６６、配列番号：１６８、配列番号：
   １７０、配列番号：１７２、配列番号：１７４、配列番
   号：１７６、配列番号：１７８、配列番号：１８０、配
   列番号：１８２、配列番号：１８４、配列番号：１８
   ６、配列番号：１８８、配列番号：１９０、配列番号：
   １９２、配列番号：１９４、配列番号：１９６、配列番
   号：１９８、配列番号：２００、配列番号：２０２、配
   列番号：２０４、配列番号：２０６、配列番号：２０
   ８、配列番号：２１０、配列番号：２１２、配列番号：
   ２１４、配列番号：２１６、配列番号：２１８、配列番
   号：２２０、配列番号：２２２、配列番号：２２４、配
   列番号：２２６、配列番号：２２８、配列番号：２３
   ０、配列番号：２３２、配列番号：２３４、配列番号：
   ２３６、配列番号：２３８、配列番号：２４０、配列番
   号：２４２、配列番号：２４４、配列番号：２４６、配
   列番号：２４８、配列番号：２５０、配列番号：２５
   ２、配列番号：２５４、配列番号：２５６、配列番号：
   ２５８、配列番号：２６０、配列番号：２６２、配列番
   号：２６４、配列番号：２６６、配列番号：２６８、配
   列番号：２７０、配列番号：２７２、配列番号：２７
   ４、配列番号：２７６、配列番号：２７８、配列番号：
   ２８０、配列番号：２８２、配列番号：２８４、配列番
   号：２８６、配列番号：２８８、配列番号：２９０、配
   列番号：２９２、配列番号：２９４、配列番号：２９
   ６、配列番号：２９８、配列番号：３００、配列番号：
   ３０２、配列番号：３０４、配列番号：３０６、配列番
   号：３０８、配列番号：３１０、配列番号：３１２、配
   列番号：３１４、配列番号：３１６、配列番号：３１
   ８、配列番号：３２０、配列番号：３２２、配列番号：
   ３２４、配列番号：３２６、配列番号：３２８、配列番
   号：３３０、配列番号：３３２、配列番号：３３４、配
   列番号：３３６、配列番号：３４２、配列番号：３４
   ４、配列番号：３４６、配列番号：３４８、および配列
   番号：３５０ （ｃ）（ｂ）に記載のアミノ酸配列から選択されたいず
   れか１つのアミノ酸配列において、１若しくは複数のア
   ミノ酸が置換、欠失、挿入、および／または付加したア
   ミノ酸配列からなり、前記選択されたアミノ酸配列から
   なる蛋白質と機能的に同等な蛋白質をコードする塩基配
   列を含むポリヌクレオチド。 （ｄ）（ａ）に記載の塩基配列から選択されたいずれか
   １つの塩基配列からなるポリヌクレオチドとハイブリダ
   イズするポリヌクレオチドであって、前記選択された塩
   基配列によってコードされる蛋白質と機能的に同等な蛋
   白質をコードする塩基配列を含むポリヌクレオチド。 （ｅ）（ａ）から（ｄ）に記載のポリヌクレオチドによ
   ってコードされる蛋白質の部分アミノ酸配列をコードす
   る塩基配列を含むポリヌクレオチド。 （ｆ）（ａ）に記載の塩基配列のいずれか１つに対して
   少なくとも７０％の同一性を有する塩基配列を含むポリ
   ヌクレオチド。
2. 【請求項２】請求項１に記載のポリヌクレオチドのいず
   れか一つによってコードされる蛋白質。
3. 【請求項３】配列番号：３７０〜配列番号：５４０のい
   ずれかの塩基配列からなるポリヌクレオチド、またはそ
   の相補鎖に相補的な少なくとも１５塩基の鎖長を有する
   オリゴヌクレオチドからなる、前記ポリヌクレオチドま
   たはその相補鎖の合成に用いるためのプライマー。
4. 【請求項４】配列番号：３７０〜配列番号：５４０のい
   ずれかの塩基配列からなるポリヌクレオチドの相補鎖に
   相補的な少なくとも１５塩基の鎖長を有するオリゴヌク
   レオチドからなるプライマーのいずれかと、オリゴdTプ
   ライマーとで構成される、ポリヌクレオチド合成用のプ
   ライマーセット。
5. 【請求項５】以下の群から選択される5'側／3'側の塩基
   配列からなるポリヌクレオチドに対して、5'側の塩基配
   列についてはその相補配列、そして3'側の塩基配列につ
   いてはその塩基配列に対して相補的な塩基配列を含む少
   なくとも１５塩基の鎖長を有するオリゴヌクレオチドの
   組み合わせのいずれかからなる、ポリヌクレオチド合成
   用のプライマーセット。 配列番号：３９１／配列番号：５４１ 配列番号：３９２／配列番号：５４２ 配列番号：３９３／配列番号：５４３ 配列番号：３９４／配列番号：５４４ 配列番号：３９５／配列番号：５４５ 配列番号：３９６／配列番号：５４６ 配列番号：３９７／配列番号：５４７ 配列番号：３９８／配列番号：５４８ 配列番号：４００／配列番号：５４９ 配列番号：４０１／配列番号：５５０ 配列番号：４０２／配列番号：５５１ 配列番号：４０３／配列番号：５５２ 配列番号：４０４／配列番号：５５３ 配列番号：４０５／配列番号：５５４ 配列番号：４０６／配列番号：５５５ 配列番号：４０７／配列番号：５５６ 配列番号：４０８／配列番号：５５７ 配列番号：４０９／配列番号：５５８ 配列番号：４１２／配列番号：５５９ 配列番号：４１３／配列番号：５６０ 配列番号：４１４／配列番号：５６１ 配列番号：４１５／配列番号：５６２ 配列番号：４１６／配列番号：５６３ 配列番号：４１７／配列番号：５６４ 配列番号：４１８／配列番号：５６５ 配列番号：４１９／配列番号：５６６ 配列番号：４２０／配列番号：５６７ 配列番号：４２１／配列番号：５６８ 配列番号：４２２／配列番号：５６９ 配列番号：４２５／配列番号：５７０ 配列番号：４２６／配列番号：５７１ 配列番号：４２７／配列番号：５７２ 配列番号：４２８／配列番号：５７３ 配列番号：４２９／配列番号：５７４ 配列番号：４３０／配列番号：５７５ 配列番号：４３１／配列番号：５７６ 配列番号：４３２／配列番号：５７７ 配列番号：４３３／配列番号：５７８ 配列番号：４３６／配列番号：５７９ 配列番号：４３７／配列番号：５８０ 配列番号：４３８／配列番号：５８１ 配列番号：４３９／配列番号：５８２ 配列番号：４４０／配列番号：５８３ 配列番号：４４１／配列番号：５８４ 配列番号：４４２／配列番号：５８５ 配列番号：４４３／配列番号：５８６ 配列番号：４４４／配列番号：５８７ 配列番号：４４５／配列番号：５８８ 配列番号：４４６／配列番号：５８９ 配列番号：４４７／配列番号：５９０ 配列番号：４４８／配列番号：５９１ 配列番号：４４９／配列番号：５９２ 配列番号：４５０／配列番号：５９３ 配列番号：４５１／配列番号：５９４ 配列番号：４５２／配列番号：５９５ 配列番号：４５３／配列番号：５９６ 配列番号：４５５／配列番号：５９７ 配列番号：４５６／配列番号：５９８ 配列番号：４５７／配列番号：５９９ 配列番号：４５８／配列番号：６００ 配列番号：４５９／配列番号：６０１ 配列番号：４６０／配列番号：６０２ 配列番号：４６１／配列番号：６０３ 配列番号：４６２／配列番号：６０４ 配列番号：４６３／配列番号：６０５ 配列番号：４６４／配列番号：６０６ 配列番号：４６５／配列番号：６０７ 配列番号：４６６／配列番号：６０８ 配列番号：４６７／配列番号：６０９ 配列番号：４６８／配列番号：６１０ 配列番号：４６９／配列番号：６１１ 配列番号：４７０／配列番号：６１２ 配列番号：４７１／配列番号：６１３ 配列番号：４７２／配列番号：６１４ 配列番号：４７３／配列番号：６１５ 配列番号：４７４／配列番号：６１６ 配列番号：４７５／配列番号：６１７ 配列番号：４７６／配列番号：６１８ 配列番号：４７７／配列番号：６１９ 配列番号：４７８／配列番号：６２０ 配列番号：４７９／配列番号：６２１ 配列番号：４８０／配列番号：６２２ 配列番号：４８１／配列番号：６２３ 配列番号：４８２／配列番号：６２４ 配列番号：４８３／配列番号：６２５ 配列番号：４８４／配列番号：６２６ 配列番号：４８５／配列番号：６２７ 配列番号：４８６／配列番号：６２８ 配列番号：４８７／配列番号：６２９ 配列番号：４８８／配列番号：６３０ 配列番号：４８９／配列番号：６３１ 配列番号：４９０／配列番号：６３２ 配列番号：４９２／配列番号：６３３ 配列番号：４９３／配列番号：６３４ 配列番号：４９４／配列番号：６３５ 配列番号：４９５／配列番号：６３６ 配列番号：４９６／配列番号：６３７ 配列番号：４９７／配列番号：６３８ 配列番号：４９８／配列番号：６３９ 配列番号：４９９／配列番号：６４０ 配列番号：５００／配列番号：６４１ 配列番号：５０１／配列番号：６４２ 配列番号：５０４／配列番号：６４３ 配列番号：５０５／配列番号：６４４ 配列番号：５０６／配列番号：６４５ 配列番号：５０７／配列番号：６４６ 配列番号：５０８／配列番号：６４７ 配列番号：５０９／配列番号：６４８ 配列番号：５１０／配列番号：６４９ 配列番号：５１１／配列番号：６５０ 配列番号：５１２／配列番号：６５１ 配列番号：５１３／配列番号：６５２ 配列番号：５１４／配列番号：６５３ 配列番号：５１５／配列番号：６５４ 配列番号：５１６／配列番号：６５５ 配列番号：５１７／配列番号：６５６ 配列番号：５１８／配列番号：６５７ 配列番号：５１９／配列番号：６５８ 配列番号：５２０／配列番号：６５９ 配列番号：５２１／配列番号：６６０ 配列番号：５２２／配列番号：６６１ 配列番号：５２３／配列番号：６６２ 配列番号：５２４／配列番号：６６３ 配列番号：５２５／配列番号：６６４ 配列番号：５２６／配列番号：６６５ 配列番号：５２７／配列番号：６６６ 配列番号：５２８／配列番号：６６７ 配列番号：５２９／配列番号：６６８ 配列番号：５３０／配列番号：６６９ 配列番号：５３１／配列番号：６７０ 配列番号：５３２／配列番号：６７１ 配列番号：５３３／配列番号：６７２ 配列番号：５３４／配列番号：６７３ 配列番号：５３５／配列番号：６７４ 配列番号：５３６／配列番号：６７５ 配列番号：５３７／配列番号：６７６ 配列番号：５３８／配列番号：６７７ 配列番号：５３９／配列番号：６７８ 配列番号：５４０／配列番号：６７９
6. 【請求項６】請求項４または請求項５に記載されたいず
   れか１組のプライマーセットによって合成することがで
   きるポリヌクレオチド。
7. 【請求項７】請求項６に記載のポリヌクレオチドにおけ
   る蛋白質コード領域を含むポリヌクレオチド。
8. 【請求項８】請求項７に記載のポリヌクレオチドがコー
   ドする蛋白質。
9. 【請求項９】請求項８に記載の蛋白質の部分ペプチド。
10. 【請求項１０】請求項２、請求項８、または請求項９に
    記載されたいずれかの蛋白質、またはペプチドに結合す
    る抗体。
11. 【請求項１１】請求項１、または請求項７に記載された
    ポリヌクレオチドのいずれか一つを含むベクター。
12. 【請求項１２】請求項１、または請求項７に記載された
    ポリヌクレオチドのいずれか一つ、または請求項１１に
    記載のベクターを保持する形質転換体。
13. 【請求項１３】請求項１、または請求項７に記載された
    ポリヌクレオチドのいずれか一つ、または請求項１１に
    記載のベクターを発現可能に保持する形質転換体。
14. 【請求項１４】請求項１３に記載の形質転換体を培養
    し、発現産物を回収する工程を含む、請求項２、請求項
    ８、または請求項９に記載されたいずれかの蛋白質また
    はペプチドの製造方法。
15. 【請求項１５】請求項１の（ａ）に記載された塩基配
    列、またはその相補鎖に相補的な塩基配列からなる１５
    ヌクレオチド以上の鎖長を持つオリゴヌクレオチド。
16. 【請求項１６】請求項１５に記載のオリゴヌクレオチド
    からなる、ポリヌクレオチド合成用プライマー。
17. 【請求項１７】請求項１５に記載のオリゴヌクレオチド
    からなる、遺伝子の検出用プローブ。
18. 【請求項１８】請求項１に記載のいずれかのポリヌクレ
    オチドもしくはその一部に対するアンチセンスポリヌク
    レオチド。
19. 【請求項１９】次の工程を含む、ポリヌクレオチドの合
    成方法。 ａ）cDNAライブラリーを鋳型として、請求項４もしくは
    請求項５に記載されたいずれか１組のプライマーセッ
    ト、または請求項１６に記載のプライマーを起点とする
    相補鎖合成反応を行い、 ｂ）合成産物を回収する。
20. 【請求項２０】cDNAライブラリーが、オリゴキャップ法
    によって合成されたものである請求項１９に記載の合成
    方法。
21. 【請求項２１】相補鎖の合成をＰＣＲ法によって行う請
    求項１９に記載の合成方法。
22. 【請求項２２】次の工程を含む、請求項１に記載のポリ
    ヌクレオチドの検出方法。 ａ）標的ポリヌクレオチドと請求項１５に記載のオリゴ
    ヌクレオチドを、ハイブリダイゼーションが可能な条件
    下でインキュベートする工程、 ｂ）標的ポリヌクレオチドと請求項１５に記載のオリゴ
    ヌクレオチドのハイブリダイゼーションを検出する工
    程。
23. 【請求項２３】請求項１の（ａ）に記載された塩基配列
    および／または請求項１の（ｂ）に記載されたアミノ酸
    配列から選択された少なくとも１つの配列情報を含むポ
    リヌクレオチドおよび／または蛋白質データベース。