JP2016105737A5 - - Google Patents
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- Publication number
- JP2016105737A5 JP2016105737A5 JP2016052380A JP2016052380A JP2016105737A5 JP 2016105737 A5 JP2016105737 A5 JP 2016105737A5 JP 2016052380 A JP2016052380 A JP 2016052380A JP 2016052380 A JP2016052380 A JP 2016052380A JP 2016105737 A5 JP2016105737 A5 JP 2016105737A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nucleic acid
- seq
- protein
- cultured
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 22
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 238000000034 method Methods 0.000 claims 12
- 235000018102 proteins Nutrition 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 12
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 4
- AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical compound OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 claims 4
- UGJBHEZMOKVTIM-UHFFFAOYSA-N N-formylglycine Chemical compound OC(=O)CNC=O UGJBHEZMOKVTIM-UHFFFAOYSA-N 0.000 claims 4
- 102000005262 Sulfatase Human genes 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 108060007951 sulfatase Proteins 0.000 claims 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- 238000004113 cell culture Methods 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261666719P | 2012-06-29 | 2012-06-29 | |
| US61/666,719 | 2012-06-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520569A Division JP6067849B2 (ja) | 2012-06-29 | 2013-06-28 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018037376A Division JP6755272B2 (ja) | 2012-06-29 | 2018-03-02 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016105737A JP2016105737A (ja) | 2016-06-16 |
| JP2016105737A5 true JP2016105737A5 (enExample) | 2016-08-12 |
| JP6302499B2 JP6302499B2 (ja) | 2018-03-28 |
Family
ID=49778522
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520569A Active JP6067849B2 (ja) | 2012-06-29 | 2013-06-28 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
| JP2016052380A Active JP6302499B2 (ja) | 2012-06-29 | 2016-03-16 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
| JP2018037376A Active JP6755272B2 (ja) | 2012-06-29 | 2018-03-02 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520569A Active JP6067849B2 (ja) | 2012-06-29 | 2013-06-28 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018037376A Active JP6755272B2 (ja) | 2012-06-29 | 2018-03-02 | 組換えイズロン酸２スルファターゼを製造するための細胞 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US9150841B2 (enExample) |
| EP (1) | EP2874649B1 (enExample) |
| JP (3) | JP6067849B2 (enExample) |
| KR (1) | KR101710487B1 (enExample) |
| CN (2) | CN104540517A (enExample) |
| AU (3) | AU2013282400B2 (enExample) |
| BR (1) | BR112014032560B1 (enExample) |
| CA (1) | CA2877521C (enExample) |
| CL (1) | CL2014003568A1 (enExample) |
| CO (1) | CO7240394A2 (enExample) |
| CR (1) | CR20140586A (enExample) |
| DO (1) | DOP2014000298A (enExample) |
| EA (2) | EA035511B1 (enExample) |
| ES (1) | ES2718346T3 (enExample) |
| GT (1) | GT201400302A (enExample) |
| HK (1) | HK1209331A1 (enExample) |
| IL (3) | IL236343A (enExample) |
| MX (2) | MX336716B (enExample) |
| MY (2) | MY189314A (enExample) |
| NZ (2) | NZ703137A (enExample) |
| PE (1) | PE20150957A1 (enExample) |
| PH (2) | PH12016500011B1 (enExample) |
| SG (2) | SG10201509397SA (enExample) |
| TR (1) | TR201904435T4 (enExample) |
| UA (1) | UA118955C2 (enExample) |
| WO (1) | WO2014005019A2 (enExample) |
| ZA (1) | ZA201409396B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DK4108671T3 (da) | 2010-10-01 | 2025-01-06 | Modernatx Inc | Modificerede nukleosider, nukleotider og nukleinsyrer samt anvendelser deraf |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| US20160145589A1 (en) | 2011-06-24 | 2016-05-26 | Green Cross Corporation | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| EP2834259A4 (en) | 2012-04-02 | 2016-08-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| CN104364369B (zh) * | 2012-05-02 | 2018-09-07 | 生命技术公司 | 哺乳动物细胞中使用独特的高密度生长和转染培养基与表达增强剂对的高产量瞬时表达 |
| KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
| US9150841B2 (en) * | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
| US20140004097A1 (en) * | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
| WO2014028429A2 (en) | 2012-08-14 | 2014-02-20 | Moderna Therapeutics, Inc. | Enzymes and polymerases for the synthesis of rna |
| US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
| WO2014159813A1 (en) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| US9550972B2 (en) | 2014-09-29 | 2017-01-24 | General Electric Company | Devices, systems and methods for automated cell culturing |
| EP3101125A1 (en) * | 2015-06-05 | 2016-12-07 | Laboratorios Del Dr. Esteve, S.A. | Adenoassociated virus vectors for the treatment of mucopolysaccharidoses |
| AU2016336344A1 (en) | 2015-10-05 | 2018-04-19 | Modernatx, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| MA50746A (fr) | 2017-10-02 | 2020-08-12 | Denali Therapeutics Inc | Protéines de fusion comprenant des enzymes d'enzymothérapie substitutive |
| JP7060235B2 (ja) * | 2018-05-18 | 2022-04-26 | 国立大学法人広島大学 | 変異型イズロン酸－２－スルファターゼの機能回復薬剤のスクリーニング方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| US5310646A (en) | 1988-05-13 | 1994-05-10 | Regents Of The University Of Minnesota | Method for the detection of mucopolysaccharide storage diseases |
| US5932211A (en) | 1991-11-12 | 1999-08-03 | Women's And Children's Hospital | Glycosylation variants of iduronate 2-sulfatase |
| AU700369B2 (en) | 1994-03-16 | 1999-01-07 | Regents Of The University Of California, The | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor |
| US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| DE19527054A1 (de) | 1995-07-26 | 1997-01-30 | Behringwerke Ag | Verfahren zur Charakterisierung der Glycosylierung von Glycoproteinen sowie zur in-vitro Bestimmung der Bioverfügbarkeit von Glycoproteinen |
| WO1998008934A1 (en) | 1996-08-30 | 1998-03-05 | Life Technologies, Inc. | Serum-free mammalian cell culture medium, and uses thereof |
| US7368531B2 (en) | 1997-03-07 | 2008-05-06 | Human Genome Sciences, Inc. | Human secreted proteins |
| US7083793B2 (en) | 1999-02-26 | 2006-08-01 | Millennium Pharmaceuticals, Inc. | Tango 243 polypeptides and uses thereof |
| EP1179000A4 (en) | 1999-02-26 | 2005-10-12 | Millennium Pharm Inc | DECISION PROTEINS AND THEIR USE |
| DE60032349T2 (de) | 1999-04-26 | 2007-07-12 | Genentech, Inc., South San Francisco | Zellenzuchtverfahren für glycoproteine |
| JP2002017376A (ja) | 1999-07-08 | 2002-01-22 | Herikkusu Kenkyusho:Kk | 分泌蛋白質、または膜蛋白質 |
| AU7099200A (en) | 1999-09-03 | 2001-04-10 | Human Genome Sciences, Inc. | 52 human secreted proteins |
| US6780627B1 (en) | 2000-01-31 | 2004-08-24 | Millennium Pharmaceuticals, Inc. | 22438, 23553, 25278, and 26212 novel human sulfatases |
| AU2001238488A1 (en) | 2000-02-17 | 2001-08-27 | Incyte Genomics, Inc. | Human kinases |
| EP1268541A1 (en) | 2000-03-17 | 2003-01-02 | Human Genome Sciences, Inc. | 7 human ovarian and ovarian cancer associated proteins |
| JP2003530838A (ja) | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
| US20030148920A1 (en) | 2000-12-27 | 2003-08-07 | Steven Rosen | Sulfatases and methods of use thereof |
| WO2002098455A2 (en) | 2001-06-07 | 2002-12-12 | Hemebiotech A/S | Production of recombinant human arylsulfatase a |
| AU2003265235A1 (en) | 2002-04-26 | 2003-12-19 | Genetech, Inc. | Non-affinity purification of proteins |
| US6890736B1 (en) | 2002-09-20 | 2005-05-10 | Immunex Corporation | Methods for producing proteins in cultured cells |
| JP4541157B2 (ja) | 2002-12-23 | 2010-09-08 | ブリストル−マイヤーズ スクイブ カンパニー | タンパク質を製造するための哺乳類細胞培養法 |
| SI2325302T1 (sl) | 2003-02-11 | 2016-05-31 | Shire Human Genetic Therapies, Inc. | Celice, ki soizražajo sulfatazo in c-formilglicin generirajoči encim ter postopki in uporabe le-teh |
| US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| WO2005113765A2 (en) | 2004-05-06 | 2005-12-01 | Biomarin Pharmaceutical Inc. | Methods of activation of sulfatases and methods and compositions of using the same |
| EP2267024B1 (en) | 2005-06-03 | 2012-05-09 | Ares Trading S.A. | Production of recombinant Il-18 binding protein |
| US20100190210A1 (en) | 2006-03-20 | 2010-07-29 | Medarex, Inc. | Protein Purification |
| MX2010007846A (es) | 2008-01-18 | 2010-10-05 | Biomarin Pharm Inc | Fabricación de enzimas sulfatasa lisosomal humana altamente fosforilada, activa y usos de las mismas. |
| KR20120093202A (ko) * | 2009-10-09 | 2012-08-22 | 다우 글로벌 테크놀로지스 엘엘씨 | 단열식 플러그 흐름 반응기 및 염화 및/또는 불화 프로펜 및 고급 알켄의 제조 방법 |
| ES2725200T3 (es) | 2009-10-09 | 2019-09-20 | Armagen Inc | Métodos y composiciones para aumentar la actividad de iduronato 2-sulfatasa en el SNC |
| JPWO2011108451A1 (ja) | 2010-03-01 | 2013-06-27 | 日本ケミカルリサーチ株式会社 | 遺伝子ノックアウト細胞を用いた組換え体リソソーム酵素の製造方法 |
| PL2593131T3 (pl) | 2010-06-25 | 2020-01-31 | Shire Human Genetic Therapies, Inc. | Sposoby i kompozycje do dostarczania sulfatazy-2-iduronianiu do oun |
| WO2012101671A1 (en) | 2011-01-25 | 2012-08-02 | Jcr Pharmaceuticals Co., Ltd. | Method for production of human recombinant iduronate 2-sulfatase |
| KR101158673B1 (ko) * | 2011-06-24 | 2012-07-03 | 주식회사 지씨바이오 | 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법 |
| US9150841B2 (en) | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
| US20140004097A1 (en) | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
| KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
-
2013
- 2013-03-14 US US13/829,780 patent/US9150841B2/en active Active
- 2013-06-28 TR TR2019/04435T patent/TR201904435T4/tr unknown
- 2013-06-28 HK HK15110031.3A patent/HK1209331A1/xx unknown
- 2013-06-28 AU AU2013282400A patent/AU2013282400B2/en active Active
- 2013-06-28 NZ NZ703137A patent/NZ703137A/en unknown
- 2013-06-28 PH PH1/2016/500011A patent/PH12016500011B1/en unknown
- 2013-06-28 EP EP13810018.5A patent/EP2874649B1/en active Active
- 2013-06-28 NZ NZ734670A patent/NZ734670A/en unknown
- 2013-06-28 BR BR112014032560-0A patent/BR112014032560B1/pt active IP Right Grant
- 2013-06-28 EA EA201492183A patent/EA035511B1/ru not_active IP Right Cessation
- 2013-06-28 CN CN201380037937.XA patent/CN104540517A/zh active Pending
- 2013-06-28 PE PE2014002538A patent/PE20150957A1/es not_active Application Discontinuation
- 2013-06-28 CN CN201710300757.6A patent/CN107267460A/zh active Pending
- 2013-06-28 MX MX2015000189A patent/MX336716B/es unknown
- 2013-06-28 KR KR1020157000841A patent/KR101710487B1/ko active Active
- 2013-06-28 WO PCT/US2013/048571 patent/WO2014005019A2/en not_active Ceased
- 2013-06-28 MY MYPI2016000156A patent/MY189314A/en unknown
- 2013-06-28 MY MYPI2014003485A patent/MY157086A/en unknown
- 2013-06-28 EA EA202090805A patent/EA202090805A1/ru unknown
- 2013-06-28 MX MX2016001229A patent/MX366155B/es unknown
- 2013-06-28 CA CA2877521A patent/CA2877521C/en active Active
- 2013-06-28 SG SG10201509397SA patent/SG10201509397SA/en unknown
- 2013-06-28 JP JP2015520569A patent/JP6067849B2/ja active Active
- 2013-06-28 SG SG11201408702VA patent/SG11201408702VA/en unknown
- 2013-06-28 UA UAA201413829A patent/UA118955C2/uk unknown
- 2013-06-28 ES ES13810018T patent/ES2718346T3/es active Active
-
2014
- 2014-12-17 CR CR20140586A patent/CR20140586A/es unknown
- 2014-12-18 IL IL236343A patent/IL236343A/en active IP Right Grant
- 2014-12-19 ZA ZA2014/09396A patent/ZA201409396B/en unknown
- 2014-12-22 PH PH12014502868A patent/PH12014502868A1/en unknown
- 2014-12-22 DO DO2014000298A patent/DOP2014000298A/es unknown
- 2014-12-26 CO CO14284192A patent/CO7240394A2/es unknown
- 2014-12-29 CL CL2014003568A patent/CL2014003568A1/es unknown
- 2014-12-29 GT GT201400302A patent/GT201400302A/es unknown
-
2015
- 2015-08-21 US US14/832,728 patent/US9719074B2/en active Active
-
2016
- 2016-01-27 AU AU2016200460A patent/AU2016200460B2/en active Active
- 2016-03-16 JP JP2016052380A patent/JP6302499B2/ja active Active
-
2017
- 2017-07-14 US US15/650,536 patent/US20180010108A1/en not_active Abandoned
- 2017-09-18 IL IL254560A patent/IL254560B/en active IP Right Grant
-
2018
- 2018-01-30 AU AU2018200710A patent/AU2018200710B2/en active Active
- 2018-03-02 JP JP2018037376A patent/JP6755272B2/ja active Active
-
2020
- 2020-04-27 IL IL274266A patent/IL274266B/en active IP Right Grant
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