MY189314A - Cells for producing recombinant iduronate-2-sulfatase - Google Patents
Cells for producing recombinant iduronate-2-sulfataseInfo
- Publication number
- MY189314A MY189314A MYPI2016000156A MYPI2016000156A MY189314A MY 189314 A MY189314 A MY 189314A MY PI2016000156 A MYPI2016000156 A MY PI2016000156A MY PI2016000156 A MYPI2016000156 A MY PI2016000156A MY 189314 A MY189314 A MY 189314A
- Authority
- MY
- Malaysia
- Prior art keywords
- cells
- sulfatase
- present
- producing recombinant
- adaptable
- Prior art date
Links
- 102100029199 Iduronate 2-sulfatase Human genes 0.000 title 1
- 101710096421 Iduronate 2-sulfatase Proteins 0.000 title 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y108/00—Oxidoreductases acting on sulfur groups as donors (1.8)
- C12Y108/99—Oxidoreductases acting on sulfur groups as donors (1.8) with other acceptors (1.8.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261666719P | 2012-06-29 | 2012-06-29 | |
| PCT/US2013/048571 WO2014005019A2 (en) | 2012-06-29 | 2013-06-28 | Cells for producing recombinant iduronate-2-sulfatase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY189314A true MY189314A (en) | 2022-02-04 |
Family
ID=49778522
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2014003485A MY157086A (en) | 2012-06-29 | 2013-06-28 | Cells for producing recombinant iduronate-2-sulfatase |
| MYPI2016000156A MY189314A (en) | 2012-06-29 | 2013-06-28 | Cells for producing recombinant iduronate-2-sulfatase |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2014003485A MY157086A (en) | 2012-06-29 | 2013-06-28 | Cells for producing recombinant iduronate-2-sulfatase |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US9150841B2 (enExample) |
| EP (1) | EP2874649B1 (enExample) |
| JP (3) | JP6067849B2 (enExample) |
| KR (1) | KR101710487B1 (enExample) |
| CN (2) | CN107267460A (enExample) |
| AU (3) | AU2013282400B2 (enExample) |
| BR (1) | BR112014032560B1 (enExample) |
| CA (1) | CA2877521C (enExample) |
| CL (1) | CL2014003568A1 (enExample) |
| CO (1) | CO7240394A2 (enExample) |
| CR (1) | CR20140586A (enExample) |
| DO (1) | DOP2014000298A (enExample) |
| EA (2) | EA202090805A1 (enExample) |
| ES (1) | ES2718346T3 (enExample) |
| GT (1) | GT201400302A (enExample) |
| HK (1) | HK1209331A1 (enExample) |
| IL (3) | IL236343A (enExample) |
| MX (2) | MX366155B (enExample) |
| MY (2) | MY157086A (enExample) |
| NZ (2) | NZ734670A (enExample) |
| PE (1) | PE20150957A1 (enExample) |
| PH (2) | PH12016500011B1 (enExample) |
| SG (2) | SG10201509397SA (enExample) |
| TR (1) | TR201904435T4 (enExample) |
| UA (1) | UA118955C2 (enExample) |
| WO (1) | WO2014005019A2 (enExample) |
| ZA (1) | ZA201409396B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2821992A1 (en) | 2010-10-01 | 2012-04-05 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| US20160145589A1 (en) | 2011-06-24 | 2016-05-26 | Green Cross Corporation | Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof |
| SI2791160T1 (sl) | 2011-12-16 | 2022-07-29 | Modernatx, Inc. | Sestave modificirane MRNA |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| AU2013243952A1 (en) | 2012-04-02 | 2014-10-30 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| JP6473079B2 (ja) * | 2012-05-02 | 2019-02-20 | ライフ テクノロジーズ コーポレーション | 高密度増殖およびトランスフェクション培地並びに発現増強物質の固有の組み合わせを用いる、哺乳類細胞における高収率一過性発現 |
| US20140004097A1 (en) * | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
| KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
| US9150841B2 (en) * | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
| US9512456B2 (en) | 2012-08-14 | 2016-12-06 | Modernatx, Inc. | Enzymes and polymerases for the synthesis of RNA |
| SMT202200337T1 (it) | 2012-11-26 | 2022-09-14 | Modernatx Inc | Rna modificato al livello del terminale |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| US9550972B2 (en) | 2014-09-29 | 2017-01-24 | General Electric Company | Devices, systems and methods for automated cell culturing |
| EP3101125A1 (en) * | 2015-06-05 | 2016-12-07 | Laboratorios Del Dr. Esteve, S.A. | Adenoassociated virus vectors for the treatment of mucopolysaccharidoses |
| AU2016336344A1 (en) | 2015-10-05 | 2018-04-19 | Modernatx, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| CA3076369A1 (en) | 2017-10-02 | 2019-04-11 | Denali Therapeutics Inc. | Fusion proteins comprising enzyme replacement therapy enzymes |
| JP7060235B2 (ja) * | 2018-05-18 | 2022-04-26 | 国立大学法人広島大学 | 変異型イズロン酸－２－スルファターゼの機能回復薬剤のスクリーニング方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| US5310646A (en) | 1988-05-13 | 1994-05-10 | Regents Of The University Of Minnesota | Method for the detection of mucopolysaccharide storage diseases |
| US5932211A (en) | 1991-11-12 | 1999-08-03 | Women's And Children's Hospital | Glycosylation variants of iduronate 2-sulfatase |
| WO1995024920A1 (en) | 1994-03-16 | 1995-09-21 | The Regents Of The University Of California | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor |
| US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| DE19527054A1 (de) | 1995-07-26 | 1997-01-30 | Behringwerke Ag | Verfahren zur Charakterisierung der Glycosylierung von Glycoproteinen sowie zur in-vitro Bestimmung der Bioverfügbarkeit von Glycoproteinen |
| EP0953041A4 (en) | 1996-08-30 | 2003-01-29 | Life Technologies Inc | SERUM-FREE CULTURAL MEDIUM FOR MAMMAL CELLS AND THEIR USE |
| US7368531B2 (en) | 1997-03-07 | 2008-05-06 | Human Genome Sciences, Inc. | Human secreted proteins |
| US7083793B2 (en) | 1999-02-26 | 2006-08-01 | Millennium Pharmaceuticals, Inc. | Tango 243 polypeptides and uses thereof |
| EP2301947A3 (en) | 1999-02-26 | 2011-11-23 | Millennium Pharmaceuticals, Inc. | Secreted proteins and uses thereof |
| PT1171615E (pt) | 1999-04-26 | 2007-03-30 | Genentech Inc | Processo de cultura celular para glicoproteínas |
| JP2002017376A (ja) | 1999-07-08 | 2002-01-22 | Herikkusu Kenkyusho:Kk | 分泌蛋白質、または膜蛋白質 |
| EP1212343A4 (en) | 1999-09-03 | 2004-11-03 | Human Genome Sciences Inc | 52 HUMAN SECRETED PROTEINS |
| US6780627B1 (en) | 2000-01-31 | 2004-08-24 | Millennium Pharmaceuticals, Inc. | 22438, 23553, 25278, and 26212 novel human sulfatases |
| JP2004502404A (ja) | 2000-02-17 | 2004-01-29 | インサイト・ゲノミックス・インコーポレイテッド | ヒトキナーゼ |
| WO2001070804A1 (en) | 2000-03-17 | 2001-09-27 | Human Genome Sciences, Inc. | 7 human ovarian and ovarian cancer associated proteins |
| EP2275557A1 (en) | 2000-04-12 | 2011-01-19 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US20030148920A1 (en) | 2000-12-27 | 2003-08-07 | Steven Rosen | Sulfatases and methods of use thereof |
| WO2002098455A2 (en) | 2001-06-07 | 2002-12-12 | Hemebiotech A/S | Production of recombinant human arylsulfatase a |
| HUE025101T2 (en) | 2002-04-26 | 2016-02-29 | Genentech Inc | Purification of proteins other than affinity purification |
| US6890736B1 (en) | 2002-09-20 | 2005-05-10 | Immunex Corporation | Methods for producing proteins in cultured cells |
| JP4541157B2 (ja) | 2002-12-23 | 2010-09-08 | ブリストル−マイヤーズ スクイブ カンパニー | タンパク質を製造するための哺乳類細胞培養法 |
| EP1592786B8 (en) | 2003-02-11 | 2012-03-21 | Shire Human Genetic Therapies, Inc. | Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies using a formylglycine generating enzyme (fge) |
| US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| WO2005113765A2 (en) | 2004-05-06 | 2005-12-01 | Biomarin Pharmaceutical Inc. | Methods of activation of sulfatases and methods and compositions of using the same |
| ES2370417T3 (es) | 2005-06-03 | 2011-12-15 | Ares Trading S.A. | Producción de una proteína de unión a il-18 recombinante. |
| KR20080111487A (ko) | 2006-03-20 | 2008-12-23 | 메다렉스, 인코포레이티드 | 단백질 정제 방법 |
| CA3112632A1 (en) | 2008-01-18 | 2009-07-23 | Biomarin Pharmaceutical Inc. | Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof |
| WO2011044522A2 (en) * | 2009-10-09 | 2011-04-14 | Dow Global Technologies, Inc | Adiabatic plug flow reactors and processes incorporating the same |
| EP2485761B1 (en) | 2009-10-09 | 2019-02-27 | Armagen, Inc. | Methods and compositions for increasing iduronate 2-sulfatase activity in the cns |
| JPWO2011108451A1 (ja) | 2010-03-01 | 2013-06-27 | 日本ケミカルリサーチ株式会社 | 遺伝子ノックアウト細胞を用いた組換え体リソソーム酵素の製造方法 |
| PL3626258T3 (pl) | 2010-06-25 | 2022-01-17 | Shire Human Genetic Therapies, Inc. | Sposoby i kompozycje do dostarczania sulfatazy-2-iduronianiu do oun |
| WO2012101671A1 (en) | 2011-01-25 | 2012-08-02 | Jcr Pharmaceuticals Co., Ltd. | Method for production of human recombinant iduronate 2-sulfatase |
| KR101158673B1 (ko) * | 2011-06-24 | 2012-07-03 | 주식회사 지씨바이오 | 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법 |
| US20140004097A1 (en) | 2012-06-29 | 2014-01-02 | Shire Human Genetic Therapies, Inc. | Method of producing recombinant iduronate-2-sulfatase |
| KR101380740B1 (ko) | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
| US9150841B2 (en) * | 2012-06-29 | 2015-10-06 | Shire Human Genetic Therapies, Inc. | Cells for producing recombinant iduronate-2-sulfatase |
-
2013
- 2013-03-14 US US13/829,780 patent/US9150841B2/en active Active
- 2013-06-28 JP JP2015520569A patent/JP6067849B2/ja active Active
- 2013-06-28 TR TR2019/04435T patent/TR201904435T4/tr unknown
- 2013-06-28 WO PCT/US2013/048571 patent/WO2014005019A2/en not_active Ceased
- 2013-06-28 MX MX2016001229A patent/MX366155B/es unknown
- 2013-06-28 AU AU2013282400A patent/AU2013282400B2/en active Active
- 2013-06-28 MY MYPI2014003485A patent/MY157086A/en unknown
- 2013-06-28 PE PE2014002538A patent/PE20150957A1/es not_active Application Discontinuation
- 2013-06-28 MY MYPI2016000156A patent/MY189314A/en unknown
- 2013-06-28 EP EP13810018.5A patent/EP2874649B1/en active Active
- 2013-06-28 SG SG10201509397SA patent/SG10201509397SA/en unknown
- 2013-06-28 EA EA202090805A patent/EA202090805A1/ru unknown
- 2013-06-28 NZ NZ734670A patent/NZ734670A/en unknown
- 2013-06-28 MX MX2015000189A patent/MX336716B/es unknown
- 2013-06-28 HK HK15110031.3A patent/HK1209331A1/xx unknown
- 2013-06-28 PH PH1/2016/500011A patent/PH12016500011B1/en unknown
- 2013-06-28 UA UAA201413829A patent/UA118955C2/uk unknown
- 2013-06-28 KR KR1020157000841A patent/KR101710487B1/ko active Active
- 2013-06-28 EA EA201492183A patent/EA035511B1/ru not_active IP Right Cessation
- 2013-06-28 CN CN201710300757.6A patent/CN107267460A/zh active Pending
- 2013-06-28 SG SG11201408702VA patent/SG11201408702VA/en unknown
- 2013-06-28 CA CA2877521A patent/CA2877521C/en active Active
- 2013-06-28 NZ NZ703137A patent/NZ703137A/en unknown
- 2013-06-28 BR BR112014032560-0A patent/BR112014032560B1/pt active IP Right Grant
- 2013-06-28 ES ES13810018T patent/ES2718346T3/es active Active
- 2013-06-28 CN CN201380037937.XA patent/CN104540517A/zh active Pending
-
2014
- 2014-12-17 CR CR20140586A patent/CR20140586A/es unknown
- 2014-12-18 IL IL236343A patent/IL236343A/en active IP Right Grant
- 2014-12-19 ZA ZA2014/09396A patent/ZA201409396B/en unknown
- 2014-12-22 PH PH12014502868A patent/PH12014502868A1/en unknown
- 2014-12-22 DO DO2014000298A patent/DOP2014000298A/es unknown
- 2014-12-26 CO CO14284192A patent/CO7240394A2/es unknown
- 2014-12-29 GT GT201400302A patent/GT201400302A/es unknown
- 2014-12-29 CL CL2014003568A patent/CL2014003568A1/es unknown
-
2015
- 2015-08-21 US US14/832,728 patent/US9719074B2/en active Active
-
2016
- 2016-01-27 AU AU2016200460A patent/AU2016200460B2/en active Active
- 2016-03-16 JP JP2016052380A patent/JP6302499B2/ja active Active
-
2017
- 2017-07-14 US US15/650,536 patent/US20180010108A1/en not_active Abandoned
- 2017-09-18 IL IL254560A patent/IL254560B/en active IP Right Grant
-
2018
- 2018-01-30 AU AU2018200710A patent/AU2018200710B2/en active Active
- 2018-03-02 JP JP2018037376A patent/JP6755272B2/ja active Active
-
2020
- 2020-04-27 IL IL274266A patent/IL274266B/en active IP Right Grant
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