CY1110525T1 - Βελτιστοποιημενη εκφραση της hpv 45 li σε ζυμη - Google Patents

Βελτιστοποιημενη εκφραση της hpv 45 li σε ζυμη

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Publication number
CY1110525T1
CY1110525T1 CY20091100973T CY091100973T CY1110525T1 CY 1110525 T1 CY1110525 T1 CY 1110525T1 CY 20091100973 T CY20091100973 T CY 20091100973T CY 091100973 T CY091100973 T CY 091100973T CY 1110525 T1 CY1110525 T1 CY 1110525T1
Authority
CY
Cyprus
Prior art keywords
hpv45
protein
vlps
yeast
hpv
Prior art date
Application number
CY20091100973T
Other languages
English (en)
Inventor
Janine T Bryan
Michelle K Brownlow
Loren D Schultz
Kathrin U Jansen
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of CY1110525T1 publication Critical patent/CY1110525T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Παρέχονται μόρια συνθετικού DNA, που κωδικεύουν την πρωτεΐνη HPV45 L1. Ειδικώτερα, η παρούσα εφεύρεση παρέχει πολυνουκλεοτίδια που κωδικεύουν την πρωτεΐνη HPV45 L1, όπου τα εν λόγω πολυνουκλεοτίδια έχουν κωδικο-βελτιοστοποιηθεί για υψηλού επιπέδου έκφραση σε κύτταρο ζύμης. Τα συνθετικά μόρια μπορεί να χρησιμοποιηθούν για την παραγωγή ιόμορφων σωματιδίων HPV45 (VLPs) και για την παραγωγή εμβολίων και φαρμακευτικών συνθέσεων που περιλαμβάνουν τα HPV45 VLPs. Τα εμβόλια της παρούσας εφεύρεσης παρέχουν δραστική ανοσοπροφύλαξη έναντι των λοιμώξεων από τους ιούς των θηλωμάτων, διαμέσου των αντισωμάτων εξουδετέρωσης και της κυτταρικής ανοσίας.
CY20091100973T 2003-09-29 2009-09-21 Βελτιστοποιημενη εκφραση της hpv 45 li σε ζυμη CY1110525T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50681203P 2003-09-29 2003-09-29
EP04788982A EP1673106B1 (en) 2003-09-29 2004-09-24 Optimized expression of hpv 45 l1 in yeast

Publications (1)

Publication Number Publication Date
CY1110525T1 true CY1110525T1 (el) 2015-04-29

Family

ID=34421558

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20091100973T CY1110525T1 (el) 2003-09-29 2009-09-21 Βελτιστοποιημενη εκφραση της hpv 45 li σε ζυμη
CY2015050C CY2015050I1 (el) 2003-09-29 2015-12-07 Βελτιστοποιημενη εκφραση της hpv 45 l1 σε ζυμη

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2015050C CY2015050I1 (el) 2003-09-29 2015-12-07 Βελτιστοποιημενη εκφραση της hpv 45 l1 σε ζυμη

Country Status (33)

Country Link
US (2) US7250170B2 (el)
EP (1) EP1673106B1 (el)
JP (4) JP5451960B2 (el)
KR (1) KR101165278B1 (el)
CN (1) CN1859923B (el)
AR (2) AR045804A1 (el)
AT (1) ATE435029T1 (el)
AU (1) AU2004277934B2 (el)
BE (1) BE2015C072I2 (el)
BR (1) BRPI0414845B8 (el)
CA (1) CA2539168C (el)
CY (2) CY1110525T1 (el)
DE (1) DE602004021828D1 (el)
DK (1) DK1673106T3 (el)
ES (1) ES2327530T3 (el)
FR (1) FR15C0083I2 (el)
HU (1) HUS1500063I1 (el)
IL (1) IL174458A (el)
IS (1) IS2694B (el)
LT (2) LTPA2015049I1 (el)
LU (1) LU92902I2 (el)
MX (1) MXPA06003457A (el)
MY (1) MY140664A (el)
NL (1) NL300776I2 (el)
NO (3) NO339932B1 (el)
NZ (1) NZ545834A (el)
PL (1) PL1673106T3 (el)
PT (1) PT1673106E (el)
RU (1) RU2360001C2 (el)
SI (1) SI1673106T1 (el)
TW (1) TWI350853B (el)
WO (1) WO2005032586A1 (el)
ZA (1) ZA200601961B (el)

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CN106282278B (zh) * 2015-06-29 2021-06-08 广东东阳光药业有限公司 一种人乳头瘤病毒l1蛋白的发酵方法
CN106701798B (zh) * 2015-08-12 2021-09-17 北京康乐卫士生物技术股份有限公司 45型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN109750050B (zh) * 2017-11-07 2023-08-18 上海泽润生物科技有限公司 重组人乳头瘤病毒45亚型蛋白表达
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CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
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Publication number Publication date
MXPA06003457A (es) 2006-06-05
NL300776I1 (el) 2015-12-29
FR15C0083I1 (fr) 2016-08-01
ZA200601961B (en) 2007-05-30
IL174458A (en) 2014-06-30
JP2011152137A (ja) 2011-08-11
TW200521233A (en) 2005-07-01
IS8362A (is) 2006-03-20
JP2016136947A (ja) 2016-08-04
ATE435029T1 (de) 2009-07-15
MY140664A (en) 2010-01-15
KR20070029628A (ko) 2007-03-14
TWI350853B (en) 2011-10-21
NO20061876L (no) 2006-04-28
BE2015C072I2 (el) 2023-12-14
AU2004277934A1 (en) 2005-04-14
LU92902I2 (fr) 2016-03-08
RU2006114701A (ru) 2007-11-10
CY2015050I2 (el) 2016-06-22
PT1673106E (pt) 2009-09-22
FR15C0083I2 (fr) 2016-11-25
HUS1500063I1 (hu) 2016-02-29
US7250170B2 (en) 2007-07-31
CN1859923B (zh) 2012-09-05
AR077396A2 (es) 2011-08-24
PL1673106T3 (pl) 2009-12-31
US20080138361A1 (en) 2008-06-12
NO2017012I1 (no) 2017-04-05
DK1673106T3 (da) 2009-11-09
CY2015050I1 (el) 2016-06-22
JP2007507207A (ja) 2007-03-29
WO2005032586A1 (en) 2005-04-14
RU2360001C2 (ru) 2009-06-27
LTPA2015049I1 (lt) 2016-01-11
US7482015B2 (en) 2009-01-27
EP1673106B1 (en) 2009-07-01
CA2539168C (en) 2011-05-31
KR101165278B1 (ko) 2012-07-23
JP5451960B2 (ja) 2014-03-26
US20060240040A1 (en) 2006-10-26
IS2694B (is) 2010-11-15
SI1673106T1 (sl) 2009-12-31
IL174458A0 (en) 2006-08-01
ES2327530T3 (es) 2009-10-30
CN1859923A (zh) 2006-11-08
BRPI0414845B8 (pt) 2021-06-15
EP1673106A1 (en) 2006-06-28
NZ545834A (en) 2009-02-28
NO339932B1 (no) 2017-02-20
CA2539168A1 (en) 2005-04-14
BRPI0414845A (pt) 2006-11-21
DE602004021828D1 (de) 2009-08-13
LTC1673106I2 (lt) 2017-05-10
NO2022051I1 (no) 2022-11-30
AR045804A1 (es) 2005-11-16
AU2004277934B2 (en) 2009-09-17
NL300776I2 (el) 2015-12-29
BRPI0414845B1 (pt) 2020-10-13
JP2014221052A (ja) 2014-11-27

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