LU92902I2 - Gardasil-9/nom du produit: protéine hpv 45 l1 - Google Patents

Gardasil-9/nom du produit: protéine hpv 45 l1 Download PDF

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Publication number
LU92902I2
LU92902I2 LU92902C LU92902C LU92902I2 LU 92902 I2 LU92902 I2 LU 92902I2 LU 92902 C LU92902 C LU 92902C LU 92902 C LU92902 C LU 92902C LU 92902 I2 LU92902 I2 LU 92902I2
Authority
LU
Luxembourg
Prior art keywords
gardasil
product name
protein hpv
hpv
protein
Prior art date
Application number
LU92902C
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English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of LU92902I2 publication Critical patent/LU92902I2/fr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • C07K14/025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20023Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
LU92902C 2003-09-29 2015-12-08 Gardasil-9/nom du produit: protéine hpv 45 l1 LU92902I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50681203P 2003-09-29 2003-09-29
PCT/US2004/031326 WO2005032586A1 (fr) 2003-09-29 2004-09-24 Expression optimisee de hpv45 l1 dans la levure

Publications (1)

Publication Number Publication Date
LU92902I2 true LU92902I2 (fr) 2016-03-08

Family

ID=34421558

Family Applications (1)

Application Number Title Priority Date Filing Date
LU92902C LU92902I2 (fr) 2003-09-29 2015-12-08 Gardasil-9/nom du produit: protéine hpv 45 l1

Country Status (33)

Country Link
US (2) US7250170B2 (fr)
EP (1) EP1673106B1 (fr)
JP (4) JP5451960B2 (fr)
KR (1) KR101165278B1 (fr)
CN (1) CN1859923B (fr)
AR (2) AR045804A1 (fr)
AT (1) ATE435029T1 (fr)
AU (1) AU2004277934B2 (fr)
BE (1) BE2015C072I2 (fr)
BR (1) BRPI0414845B8 (fr)
CA (1) CA2539168C (fr)
CY (2) CY1110525T1 (fr)
DE (1) DE602004021828D1 (fr)
DK (1) DK1673106T3 (fr)
ES (1) ES2327530T3 (fr)
FR (1) FR15C0083I2 (fr)
HU (1) HUS1500063I1 (fr)
IL (1) IL174458A (fr)
IS (1) IS2694B (fr)
LT (2) LTC1673106I2 (fr)
LU (1) LU92902I2 (fr)
MX (1) MXPA06003457A (fr)
MY (1) MY140664A (fr)
NL (1) NL300776I2 (fr)
NO (2) NO339932B1 (fr)
NZ (1) NZ545834A (fr)
PL (1) PL1673106T3 (fr)
PT (1) PT1673106E (fr)
RU (1) RU2360001C2 (fr)
SI (1) SI1673106T1 (fr)
TW (1) TWI350853B (fr)
WO (1) WO2005032586A1 (fr)
ZA (1) ZA200601961B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
US7858098B2 (en) * 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
MY139500A (en) 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
CA2560487C (fr) * 2004-03-24 2013-01-29 Merck & Co., Inc. Expression optimisee de hpv 52 l1 dans une levure
US7758866B2 (en) 2004-06-16 2010-07-20 Glaxosmithkline Biologicals, S.A. Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
EP1877087B1 (fr) 2005-04-15 2013-02-20 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Procedes et compositions permettant de produire une reponse immunitaire amelioree contre un immunogene papillomavirus humain
CA2606092A1 (fr) * 2005-04-26 2006-11-02 Glaxosmithkline Biologicals S.A. Vaccin
KR100904844B1 (ko) * 2006-08-28 2009-06-25 성균관대학교산학협력단 인유두종 바이러스(hpv)유전자를 포함하는자궁경부암의 치료 또는 예방용 dna 백신
EP2129394B1 (fr) * 2007-03-09 2012-06-20 Merck Sharp & Dohme Corp. Compositions de vaccin contre le papillomavirus
CN101835797A (zh) 2007-11-23 2010-09-15 上海泽润生物科技有限公司 人乳头状瘤病毒主要衣壳蛋白l1基因及其用途
JP5758385B2 (ja) 2009-06-19 2015-08-05 アイジェン インコーポレーテッド 子宮頸がんワクチン
JP6153866B2 (ja) 2010-05-25 2017-06-28 キアゲン ガイサーズバーグ アイエヌシー. 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ
BR112013032338B1 (pt) * 2011-06-15 2021-04-20 Posvax Co., Ltd método para melhorar o rendimento de produção para proteína l1 do papilomavírus humano
JP6050811B2 (ja) 2011-06-24 2016-12-21 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. アルミニウムアジュバントを含むhpvワクチン製剤およびその産生方法
CN103215302B (zh) * 2012-01-21 2019-01-15 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv18 l1蛋白的方法
CN103361280B (zh) * 2012-03-28 2018-07-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv11 l1蛋白的方法
CN110423774A (zh) * 2013-04-26 2019-11-08 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv58 l1蛋白的方法
CN110484554B (zh) * 2013-04-26 2024-04-16 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv52 l1蛋白的方法
CN110295190A (zh) * 2013-05-17 2019-10-01 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv45 l1蛋白的方法
CN112280792B (zh) * 2013-09-29 2022-06-24 上海泽润生物科技有限公司 人乳头瘤病毒基因,及载体,菌株,表达方法
EP3057612B1 (fr) 2013-10-16 2020-05-06 Merck Sharp & Dohme Corp. Procédé d'obtention de formulations de vaccin séchées thermostables
AR101840A1 (es) * 2014-09-11 2017-01-18 Cadila Healthcare Ltd Antígenos del virus del papiloma humano superiores con propiedades inmunológicas superiores, y vacuna que los contiene
CN106282278B (zh) * 2015-06-29 2021-06-08 广东东阳光药业有限公司 一种人乳头瘤病毒l1蛋白的发酵方法
CN106701798B (zh) * 2015-08-12 2021-09-17 北京康乐卫士生物技术股份有限公司 45型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN109750050B (zh) * 2017-11-07 2023-08-18 上海泽润生物科技有限公司 重组人乳头瘤病毒45亚型蛋白表达
JP2023516904A (ja) 2020-02-14 2023-04-21 メルク・シャープ・アンド・ドーム・エルエルシー Hpvワクチン
CN112680462B (zh) * 2020-12-29 2022-02-22 上海博唯生物科技有限公司 一种人乳头瘤病毒35型/hpv35型l1/l2及其制备与应用
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
TW202313658A (zh) 2021-08-06 2023-04-01 美商默沙東有限責任公司 Hpv疫苗
WO2023023152A1 (fr) 2021-08-19 2023-02-23 Merck Sharp & Dohme Llc Nanoparticule lipidique thermostable et ses méthodes d'utilisation

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CA2189882C (fr) * 1994-05-16 2005-09-20 Kathrin U. Jansen Vaccins contre le papillomavirus
AR004464A1 (es) 1994-11-14 1998-12-16 Merck Sharp & Dohme Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) * 1995-03-22 2005-11-20 Merck & Co Inc Dna encoding human papillomavirus type 18
IL117591A0 (en) * 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
EE9900343A (et) 1997-02-07 2000-02-15 Merck & Co., Inc. Sünteetiline polünukleotiid, immuunvastuste tekitamise meetod, immunogeenne kompositsioon, anti-HIV immuunvastuste indutseerimise meetod, meetod antigeeni tekitava raku indutseerimiseks ja farmatseutiline kompositsioon
DE69732378D1 (de) * 1997-05-27 2005-03-03 Hanil Synthetic Fiber Co Ltd Verfahren zur herstellung von rekombinanten eiweissen durch verwendung von hocheffizienten expressionsvektoren aus saccharomyces cerevisiae
CA2296067C (fr) 1997-07-09 2008-10-07 The University Of Queensland Sequence d'acides nucleiques et procede pour exprimer, de maniere selective, une proteine dans une cellule ou un tissu cible
US6991795B1 (en) * 1998-08-14 2006-01-31 Merck & Co., Inc. Protein delivery system using human papillomavirus virus-like particles
AU753391B2 (en) * 1998-08-14 2002-10-17 Merck Sharp & Dohme Corp. Protein delivery system using human papillomavirus virus-like particles
EP1140974B1 (fr) * 1998-12-23 2005-03-02 Merck & Co., Inc. Dosage neutralisant utilisant des particules veriformes du papillomavirus humain
ATE284898T1 (de) * 1999-08-25 2005-01-15 Merck & Co Inc Synthetische papillomavirus gene, welche für expression in menschlichen zellen optimiert sind
US6436402B1 (en) * 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
US7026443B1 (en) * 1999-12-10 2006-04-11 Epimmune Inc. Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
IL154009A0 (en) 2000-07-21 2003-07-31 Glaxo Group Ltd Codon-optimized papilloma virus sequences
US20040121465A1 (en) * 2002-02-14 2004-06-24 Novavax, Inc. Optimization of gene sequences of virus-like particles for expression in insect cells
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
CN100506999C (zh) 2003-03-24 2009-07-01 麦克公司 Hpv31l1在酵母中的优化表达

Also Published As

Publication number Publication date
PL1673106T3 (pl) 2009-12-31
CY2015050I1 (el) 2016-06-22
AU2004277934A1 (en) 2005-04-14
NO2017012I1 (no) 2017-04-05
ZA200601961B (en) 2007-05-30
CA2539168C (fr) 2011-05-31
WO2005032586A1 (fr) 2005-04-14
LTPA2015049I1 (lt) 2016-01-11
JP2007507207A (ja) 2007-03-29
AU2004277934B2 (en) 2009-09-17
EP1673106A1 (fr) 2006-06-28
TWI350853B (en) 2011-10-21
CN1859923A (zh) 2006-11-08
BE2015C072I2 (fr) 2023-12-14
US20060240040A1 (en) 2006-10-26
DK1673106T3 (da) 2009-11-09
BRPI0414845B1 (pt) 2020-10-13
RU2360001C2 (ru) 2009-06-27
PT1673106E (pt) 2009-09-22
US20080138361A1 (en) 2008-06-12
JP2014221052A (ja) 2014-11-27
AR045804A1 (es) 2005-11-16
TW200521233A (en) 2005-07-01
IL174458A0 (en) 2006-08-01
ATE435029T1 (de) 2009-07-15
CA2539168A1 (fr) 2005-04-14
NL300776I1 (fr) 2015-12-29
FR15C0083I1 (fr) 2016-08-01
CN1859923B (zh) 2012-09-05
US7482015B2 (en) 2009-01-27
MXPA06003457A (es) 2006-06-05
ES2327530T3 (es) 2009-10-30
NO339932B1 (no) 2017-02-20
CY1110525T1 (el) 2015-04-29
MY140664A (en) 2010-01-15
JP2016136947A (ja) 2016-08-04
RU2006114701A (ru) 2007-11-10
IL174458A (en) 2014-06-30
EP1673106B1 (fr) 2009-07-01
AR077396A2 (es) 2011-08-24
IS8362A (is) 2006-03-20
NZ545834A (en) 2009-02-28
US7250170B2 (en) 2007-07-31
BRPI0414845B8 (pt) 2021-06-15
FR15C0083I2 (fr) 2016-11-25
NO20061876L (no) 2006-04-28
NL300776I2 (fr) 2015-12-29
JP5451960B2 (ja) 2014-03-26
SI1673106T1 (sl) 2009-12-31
DE602004021828D1 (de) 2009-08-13
BRPI0414845A (pt) 2006-11-21
HUS1500063I1 (hu) 2016-02-29
KR20070029628A (ko) 2007-03-14
JP2011152137A (ja) 2011-08-11
KR101165278B1 (ko) 2012-07-23
LTC1673106I2 (lt) 2017-05-10
IS2694B (is) 2010-11-15
CY2015050I2 (el) 2016-06-22

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