LU92902I2 - GARDASIL-9 / PRODUCT NAME: PROTEIN HPV 45 L1 - Google Patents

GARDASIL-9 / PRODUCT NAME: PROTEIN HPV 45 L1 Download PDF

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Publication number
LU92902I2
LU92902I2 LU92902C LU92902C LU92902I2 LU 92902 I2 LU92902 I2 LU 92902I2 LU 92902 C LU92902 C LU 92902C LU 92902 C LU92902 C LU 92902C LU 92902 I2 LU92902 I2 LU 92902I2
Authority
LU
Luxembourg
Prior art keywords
gardasil
product name
protein hpv
hpv
protein
Prior art date
Application number
LU92902C
Other languages
French (fr)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of LU92902I2 publication Critical patent/LU92902I2/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • C07K14/025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20023Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
LU92902C 2003-09-29 2015-12-08 GARDASIL-9 / PRODUCT NAME: PROTEIN HPV 45 L1 LU92902I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50681203P 2003-09-29 2003-09-29
PCT/US2004/031326 WO2005032586A1 (en) 2003-09-29 2004-09-24 Optimized expression of hpv 45 l1 in yeast

Publications (1)

Publication Number Publication Date
LU92902I2 true LU92902I2 (en) 2016-03-08

Family

ID=34421558

Family Applications (1)

Application Number Title Priority Date Filing Date
LU92902C LU92902I2 (en) 2003-09-29 2015-12-08 GARDASIL-9 / PRODUCT NAME: PROTEIN HPV 45 L1

Country Status (33)

Country Link
US (2) US7250170B2 (en)
EP (1) EP1673106B1 (en)
JP (4) JP5451960B2 (en)
KR (1) KR101165278B1 (en)
CN (1) CN1859923B (en)
AR (2) AR045804A1 (en)
AT (1) ATE435029T1 (en)
AU (1) AU2004277934B2 (en)
BE (1) BE2015C072I2 (en)
BR (1) BRPI0414845B8 (en)
CA (1) CA2539168C (en)
CY (2) CY1110525T1 (en)
DE (1) DE602004021828D1 (en)
DK (1) DK1673106T3 (en)
ES (1) ES2327530T3 (en)
FR (1) FR15C0083I2 (en)
HU (1) HUS1500063I1 (en)
IL (1) IL174458A (en)
IS (1) IS2694B (en)
LT (2) LTPA2015049I1 (en)
LU (1) LU92902I2 (en)
MX (1) MXPA06003457A (en)
MY (1) MY140664A (en)
NL (1) NL300776I2 (en)
NO (3) NO339932B1 (en)
NZ (1) NZ545834A (en)
PL (1) PL1673106T3 (en)
PT (1) PT1673106E (en)
RU (1) RU2360001C2 (en)
SI (1) SI1673106T1 (en)
TW (1) TWI350853B (en)
WO (1) WO2005032586A1 (en)
ZA (1) ZA200601961B (en)

Families Citing this family (31)

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GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
US7858098B2 (en) 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
MY139500A (en) 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
EP1730175B1 (en) 2004-03-24 2010-04-28 Merck Sharp & Dohme Corp. Optimized expression of hpv 52 l1 in yeast
US7758866B2 (en) 2004-06-16 2010-07-20 Glaxosmithkline Biologicals, S.A. Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
CA2604909A1 (en) 2005-04-15 2006-10-26 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
EP1877086A2 (en) * 2005-04-26 2008-01-16 GlaxoSmithKline Biologicals SA Vaccine
EP2059262B1 (en) * 2006-08-28 2013-08-21 Sungkyunkwan University Foundation for Corporate Collaboration A dna vaccine for treating or preventing cervical cancer comprising a gene encoding hpv protein
EP2129394B1 (en) * 2007-03-09 2012-06-20 Merck Sharp & Dohme Corp. Papillomavirus vaccine compositions
EP2479187A1 (en) 2007-11-23 2012-07-25 Shanghai Zerun Biotechnology Co., Ltd. Genes encoding major capsid protein L1 of human papilloma viruses
US9566323B2 (en) 2009-06-19 2017-02-14 Eyegene Inc. Vaccine for cervical cancer
JP6153866B2 (en) 2010-05-25 2017-06-28 キアゲン ガイサーズバーグ アイエヌシー. Rapid hybrid capture assay and associated strategically cleaved probe
BR112013032338B1 (en) 2011-06-15 2021-04-20 Posvax Co., Ltd method to improve production yield for human papillomavirus l1 protein
US20140127260A1 (en) 2011-06-24 2014-05-08 Ramesh V. Chintala Hpv vaccine formulations comprising aluminum adjuvant and methods of producing same
CN103215302B (en) * 2012-01-21 2019-01-15 北京安百胜生物科技有限公司 Method for producing HPV18 L1 protein using the Hansenula yeast expression system
CN108624614A (en) * 2012-03-28 2018-10-09 北京安百胜生物科技有限公司 The method for generating HPV11 L1 albumen with expressed by Hansenula yeast system
CN110423774A (en) * 2013-04-26 2019-11-08 北京安百胜生物科技有限公司 The method for generating HPV58 L1 albumen with expressed by Hansenula yeast system
CN110484554B (en) * 2013-04-26 2024-04-16 北京安百胜生物科技有限公司 Method for producing HPV52L1 protein by Hansenula polymorpha expression system
CN110295190A (en) * 2013-05-17 2019-10-01 北京安百胜生物科技有限公司 The method for generating HPV45 L1 albumen with expressed by Hansenula yeast system
CN112280792B (en) * 2013-09-29 2022-06-24 上海泽润生物科技有限公司 Human papillomavirus gene, and vector, strain, and expression method
US9782470B2 (en) 2013-10-16 2017-10-10 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
EP3191505A2 (en) * 2014-09-11 2017-07-19 Cadila Healthcare Limited Superior human papilloma virus antigens with superior immunological properties and vaccine containing it
CN106282278B (en) * 2015-06-29 2021-06-08 广东东阳光药业有限公司 A kind of fermentation method of human papillomavirus L1 protein
CN106701798B (en) * 2015-08-12 2021-09-17 北京康乐卫士生物技术股份有限公司 Type 45 recombinant human papillomavirus virus-like particle and preparation method thereof
CN109750050B (en) * 2017-11-07 2023-08-18 上海泽润生物科技有限公司 Expression of Recombinant Human Papillomavirus Subtype 45 Protein
CN115103687A (en) 2020-02-14 2022-09-23 默沙东有限公司 HPV vaccine
CN112680462B (en) * 2020-12-29 2022-02-22 上海博唯生物科技有限公司 Human papilloma virus 35/HPV 35 type L1/L2 and preparation and application thereof
CN113073105B (en) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 Polynucleotide sequence for expressing HPV56L1, expression vector, host cell and application thereof
WO2023014853A1 (en) 2021-08-06 2023-02-09 Merck Sharp & Dohme Llc Hpv vaccine
TW202315602A (en) 2021-08-19 2023-04-16 美商默沙東有限責任公司 Novel thermostable lipid nanoparticle and methods of use thereof
AR132886A1 (en) 2023-06-09 2025-08-06 Merck Sharp & Dohme Llc Adjuvant compositions in nanoemulsion for vaccines against human papillomavirus

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Also Published As

Publication number Publication date
US7482015B2 (en) 2009-01-27
NO20061876L (en) 2006-04-28
IS8362A (en) 2006-03-20
AR045804A1 (en) 2005-11-16
AU2004277934A1 (en) 2005-04-14
BRPI0414845B1 (en) 2020-10-13
CA2539168C (en) 2011-05-31
PL1673106T3 (en) 2009-12-31
JP2014221052A (en) 2014-11-27
JP2007507207A (en) 2007-03-29
KR20070029628A (en) 2007-03-14
HUS1500063I1 (en) 2016-02-29
RU2360001C2 (en) 2009-06-27
SI1673106T1 (en) 2009-12-31
NO339932B1 (en) 2017-02-20
JP2016136947A (en) 2016-08-04
IS2694B (en) 2010-11-15
CY2015050I2 (en) 2016-06-22
TW200521233A (en) 2005-07-01
FR15C0083I2 (en) 2016-11-25
TWI350853B (en) 2011-10-21
KR101165278B1 (en) 2012-07-23
NO2022051I1 (en) 2022-11-30
JP5451960B2 (en) 2014-03-26
WO2005032586A1 (en) 2005-04-14
LTC1673106I2 (en) 2017-05-10
NZ545834A (en) 2009-02-28
US20060240040A1 (en) 2006-10-26
ATE435029T1 (en) 2009-07-15
FR15C0083I1 (en) 2016-08-01
AU2004277934B2 (en) 2009-09-17
AR077396A2 (en) 2011-08-24
JP2011152137A (en) 2011-08-11
CA2539168A1 (en) 2005-04-14
EP1673106B1 (en) 2009-07-01
LTPA2015049I1 (en) 2016-01-11
MY140664A (en) 2010-01-15
CN1859923A (en) 2006-11-08
CN1859923B (en) 2012-09-05
DK1673106T3 (en) 2009-11-09
BE2015C072I2 (en) 2023-12-14
EP1673106A1 (en) 2006-06-28
ES2327530T3 (en) 2009-10-30
IL174458A (en) 2014-06-30
CY2015050I1 (en) 2016-06-22
NO2017012I1 (en) 2017-04-05
ZA200601961B (en) 2007-05-30
IL174458A0 (en) 2006-08-01
NL300776I1 (en) 2015-12-29
PT1673106E (en) 2009-09-22
BRPI0414845A (en) 2006-11-21
NL300776I2 (en) 2015-12-29
RU2006114701A (en) 2007-11-10
CY1110525T1 (en) 2015-04-29
US20080138361A1 (en) 2008-06-12
BRPI0414845B8 (en) 2021-06-15
MXPA06003457A (en) 2006-06-05
US7250170B2 (en) 2007-07-31
DE602004021828D1 (en) 2009-08-13

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