RU2006114701A - Оптимизированная экспрессия l1 hpv45 в дрожжах - Google Patents
Оптимизированная экспрессия l1 hpv45 в дрожжах Download PDFInfo
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- RU2006114701A RU2006114701A RU2006114701/13A RU2006114701A RU2006114701A RU 2006114701 A RU2006114701 A RU 2006114701A RU 2006114701/13 A RU2006114701/13 A RU 2006114701/13A RU 2006114701 A RU2006114701 A RU 2006114701A RU 2006114701 A RU2006114701 A RU 2006114701A
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- particles
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- recombinant
- vlp particles
- yeast
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- 240000004808 Saccharomyces cerevisiae Species 0.000 title claims 10
- 239000002245 particle Substances 0.000 claims 16
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 9
- 229960005486 vaccine Drugs 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 208000022361 Human papillomavirus infectious disease Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 241000341655 Human papillomavirus type 16 Species 0.000 claims 2
- 235000014663 Kluyveromyces fragilis Nutrition 0.000 claims 2
- 241000235650 Kluyveromyces marxianus Species 0.000 claims 2
- 241000235058 Komagataella pastoris Species 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 241000320412 Ogataea angusta Species 0.000 claims 2
- 241001631646 Papillomaviridae Species 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000235649 Kluyveromyces Species 0.000 claims 1
- 241001138401 Kluyveromyces lactis Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000009608 Papillomavirus Infections Diseases 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- 241000235347 Schizosaccharomyces pombe Species 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Bioinformatics & Cheminformatics (AREA)
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- Wood Science & Technology (AREA)
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- Biotechnology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
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- Reproductive Health (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Claims (25)
1. Молекула нуклеиновой кислоты, содержащая последовательность нуклеотидов, которая кодирует белок L1 HPV45, представленный SEQ ID NO:2, причем данная последовательность нуклеиновой кислоты является кодон-оптимизированной для высокоуровневой экспрессии в дрожжевой клетке.
2. Вектор, содержащий молекулу нуклеиновой кислоты по п.1.
3. Клетка-хозяин, содержащая вектор по п.2.
4. Клетка-хозяин по п.3, где клетка-хозяин выбрана из группы, состоящей из Saccharomyces cerevisiae, Hansenula polymorpha, Pichia pastoris, lactis, и Schizosaccharomyces Kluyveromyces fragilis, Kluyveromyces pombe.
5. Клетка-хозяин по п.4, где данная клетка-хозяин представляет собой Saccharomyces cerevisiae.
6. Молекула нуклеиновой кислоты по п.1, в которой последовательность нуклеотидов содержит последовательность нуклеотидов, представленную SEQ ID NO:1.
7. Вектор, содержащий молекулу нуклеиновой кислоты по п.6.
8. Клетка-хозяин, содержащая вектор по п.7.
9. Вирусоподобные частицы (VLP), образованные рекомбинантным белком L1 или рекомбинантными белками L1+L2 HPV45, где рекомбинантный белок L1 или данные рекомбинантные белки L1+L2 продуцируются в дрожжах.
10. VLP-частицы по п.9, где рекомбинантный белок L1 или рекомбинантные белки L1+L2 кодируются кодон-оптимизированной молекулой нуклеиновой кислоты L1 HPV45.
11. VLP-частицы по п.10, где кодон-оптимизированная молекула нуклеиновой кислоты состоит, в сущности, из последовательности нуклеотидов, представленной SEQ ID NO:1.
12. Способ получения VLP-частиц по п.10, включающий в себя:
(а) трансформирование дрожжей кодон-оптимизированной молекулой ДНК, кодирующей белок L1 HPV45 или белки L1+L2 HPV45;
(b) культивирование трансформиронных дрожжей в условиях, которые делают возможной экспрессию кодон-оптимизированной молекулы ДНК c получением рекомбинантного белка вируса папилломы; и
(с) выделение рекомбинантного белка вируса папилломы для получения VLP-частиц по п.10.
13. Вакцина, содержащая VLP-частицы по п.10.
14. Фармацевтические композиции, содержащие VLP-частицы по п.10.
15. Способ предотвращения HPV-заражения, предусматривающий введение млекопитающему вакцины по п.13.
16. Способ индукции иммунного ответа у животного, предусматривающий введение животному VLP-частиц по п.10.
17. Вирусоподобные частицы по п.10, где дрожжи выбраны из группы, состоящей из Saccharomyces cerevisiae, Hansenula polymorpha, Pichia pastoris, Kluyveromyces fragilis, Kluyveromyces lactis, и Schizosaccharomyces pombe.
18. Вирусоподобные частицы по п.17, где дрожжи представляют собой Saccharomyces cerevisiae.
19. Вакцина по п.13, дополнительно содержащая VLP-частицы, по меньшей мере, из одного дополнительного HPV-типа.
20. Вакцина по п.19, в которой, по меньшей мере, один дополнительный HPV-тип выбран из группы, состоящей из HPV6, HPV11, HPV16, HPV18, HPV31, HPV33, HPV35, HPV39, HPV51, HPV52, HPV55, HPV56, HPV58, HPV59, и HPV68.
21. Вакцина по п. 20, в которой, по меньшей мере, один HPV-тип включает в себя HPV16.
22. Вакцина по п. 21, дополнительно содержащая VLP-частицы HPV18.
23. Вакцина по п. 22, дополнительно содержащая VLP-частицы HPV6 и VLP-частицы HPV11.
24. Вакцина по п. 23, дополнительно содержащая VLP-частицы HPV31.
25. Вакцина по п. 22, дополнительно содержащая VLP-частицы HPV31.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50681203P | 2003-09-29 | 2003-09-29 | |
US60/506,812 | 2003-09-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2006114701A true RU2006114701A (ru) | 2007-11-10 |
RU2360001C2 RU2360001C2 (ru) | 2009-06-27 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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RU2006114701/13A RU2360001C2 (ru) | 2003-09-29 | 2004-09-24 | Оптимизированная экспрессия l1 hpv45 в дрожжах |
Country Status (33)
Country | Link |
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US (2) | US7250170B2 (ru) |
EP (1) | EP1673106B1 (ru) |
JP (4) | JP5451960B2 (ru) |
KR (1) | KR101165278B1 (ru) |
CN (1) | CN1859923B (ru) |
AR (2) | AR045804A1 (ru) |
AT (1) | ATE435029T1 (ru) |
AU (1) | AU2004277934B2 (ru) |
BE (1) | BE2015C072I2 (ru) |
BR (1) | BRPI0414845B8 (ru) |
CA (1) | CA2539168C (ru) |
CY (2) | CY1110525T1 (ru) |
DE (1) | DE602004021828D1 (ru) |
DK (1) | DK1673106T3 (ru) |
ES (1) | ES2327530T3 (ru) |
FR (1) | FR15C0083I2 (ru) |
HU (1) | HUS1500063I1 (ru) |
IL (1) | IL174458A (ru) |
IS (1) | IS2694B (ru) |
LT (2) | LTC1673106I2 (ru) |
LU (1) | LU92902I2 (ru) |
MX (1) | MXPA06003457A (ru) |
MY (1) | MY140664A (ru) |
NL (1) | NL300776I1 (ru) |
NO (2) | NO339932B1 (ru) |
NZ (1) | NZ545834A (ru) |
PL (1) | PL1673106T3 (ru) |
PT (1) | PT1673106E (ru) |
RU (1) | RU2360001C2 (ru) |
SI (1) | SI1673106T1 (ru) |
TW (1) | TWI350853B (ru) |
WO (1) | WO2005032586A1 (ru) |
ZA (1) | ZA200601961B (ru) |
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GB0206360D0 (en) | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
US7858098B2 (en) | 2002-12-20 | 2010-12-28 | Glaxosmithkline Biologicals, S.A. | Vaccine |
MY139500A (en) | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
PL1730175T3 (pl) | 2004-03-24 | 2010-09-30 | Merck Sharp & Dohme | Optymalizowana ekspresja L1 HPV 52 w drożdżach |
US7758866B2 (en) | 2004-06-16 | 2010-07-20 | Glaxosmithkline Biologicals, S.A. | Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52 |
WO2006113209A1 (en) | 2005-04-15 | 2006-10-26 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen |
MX2007013472A (es) * | 2005-04-26 | 2008-04-02 | Glaxosmithkline Biolog Sa | Vacuna. |
WO2008026869A1 (en) * | 2006-08-28 | 2008-03-06 | Sungkyunkwan University Foundation For Corporate Collaboration | A dna vaccine for treating or preventing cervical cancer comprising a gene encoding hpv protein |
US7709010B2 (en) * | 2007-03-09 | 2010-05-04 | Merck Sharp & Dohme Corp. | Papillomavirus vaccine compositions |
WO2009076824A1 (zh) * | 2007-11-23 | 2009-06-25 | Shanghai Zerun Biotechnology Co., Ltd. | 人乳头状瘤病毒主要衣壳蛋白l1基因及其用途 |
MX2011013566A (es) | 2009-06-19 | 2012-06-28 | Eyegene Inc | Vacunas para cancer cervical. |
JP6153866B2 (ja) | 2010-05-25 | 2017-06-28 | キアゲン ガイサーズバーグ アイエヌシー. | 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ |
CN103717741B (zh) * | 2011-06-15 | 2016-04-13 | 中央大学校产学协力团 | 用于提高人乳头瘤病毒l1蛋白产量的方法 |
ES2762230T3 (es) | 2011-06-24 | 2020-05-22 | Merck Sharp & Dohme | Formulaciones de vacuna contra el HPV que comprenden un adyuvante de aluminio y métodos de producción de las mismas |
CN103215302B (zh) * | 2012-01-21 | 2019-01-15 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv18 l1蛋白的方法 |
CN108624614A (zh) * | 2012-03-28 | 2018-10-09 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv11 l1蛋白的方法 |
CN104120089B (zh) * | 2013-04-26 | 2019-09-24 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv52 l1蛋白的方法 |
CN110423774A (zh) * | 2013-04-26 | 2019-11-08 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv58 l1蛋白的方法 |
CN104164447B (zh) * | 2013-05-17 | 2019-08-13 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv45 l1蛋白的方法 |
CN104513826B (zh) * | 2013-09-29 | 2020-10-20 | 上海泽润生物科技有限公司 | 人乳头瘤病毒基因,及载体,菌株,表达方法 |
CA2927434C (en) | 2013-10-16 | 2022-07-19 | Merck Sharp & Dohme Corp. | Method of obtaining thermostable dried vaccine formulations |
WO2016038625A2 (en) * | 2014-09-11 | 2016-03-17 | Cadila Healthcare Limited | Superior human papilloma virus antigens with superior immunological properties and vaccine containing it |
CN106282278B (zh) * | 2015-06-29 | 2021-06-08 | 广东东阳光药业有限公司 | 一种人乳头瘤病毒l1蛋白的发酵方法 |
CN106701798B (zh) * | 2015-08-12 | 2021-09-17 | 北京康乐卫士生物技术股份有限公司 | 45型重组人乳头瘤病毒病毒样颗粒及其制备方法 |
CN109750050B (zh) * | 2017-11-07 | 2023-08-18 | 上海泽润生物科技有限公司 | 重组人乳头瘤病毒45亚型蛋白表达 |
PE20230493A1 (es) | 2020-02-14 | 2023-03-23 | Merck Sharp And Dohme Llc | Vacuna contra hpv |
CN112680462B (zh) * | 2020-12-29 | 2022-02-22 | 上海博唯生物科技有限公司 | 一种人乳头瘤病毒35型/hpv35型l1/l2及其制备与应用 |
CN113073105B (zh) * | 2021-03-23 | 2023-06-13 | 重庆博唯佰泰生物制药有限公司 | 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用 |
AR126708A1 (es) | 2021-08-06 | 2023-11-08 | Merck Sharp & Dohme Llc | Vacuna para el vph |
TW202315602A (zh) | 2021-08-19 | 2023-04-16 | 美商默沙東有限責任公司 | 新穎熱穩定脂質奈米粒子及其使用方法 |
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