JP2017500024A5 - - Google Patents
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- JP2017500024A5 JP2017500024A5 JP2016536954A JP2016536954A JP2017500024A5 JP 2017500024 A5 JP2017500024 A5 JP 2017500024A5 JP 2016536954 A JP2016536954 A JP 2016536954A JP 2016536954 A JP2016536954 A JP 2016536954A JP 2017500024 A5 JP2017500024 A5 JP 2017500024A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- amino acid
- polypeptide
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911759P | 2013-12-04 | 2013-12-04 | |
| US61/911,759 | 2013-12-04 | ||
| US201462050399P | 2014-09-15 | 2014-09-15 | |
| US62/050,399 | 2014-09-15 | ||
| PCT/CA2014/051164 WO2015081437A1 (en) | 2013-12-04 | 2014-12-03 | Compositions and methods for making (r)-reticuline and precursors thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017500024A JP2017500024A (ja) | 2017-01-05 |
| JP2017500024A5 true JP2017500024A5 (enExample) | 2020-01-30 |
| JP6783655B2 JP6783655B2 (ja) | 2020-11-11 |
Family
ID=53272687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536954A Active JP6783655B2 (ja) | 2013-12-04 | 2014-12-03 | （ｒ）−レチクリンおよびその前駆体を製造するための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10190141B2 (enExample) |
| EP (2) | EP3077513B1 (enExample) |
| JP (1) | JP6783655B2 (enExample) |
| KR (2) | KR102018240B1 (enExample) |
| CN (3) | CN115927140A (enExample) |
| AU (4) | AU2014360597B2 (enExample) |
| BR (1) | BR112016012595B1 (enExample) |
| CA (1) | CA2932448C (enExample) |
| DK (1) | DK3077513T5 (enExample) |
| ES (1) | ES2961516T3 (enExample) |
| IL (2) | IL245970B (enExample) |
| MX (1) | MX364825B (enExample) |
| RU (1) | RU2729065C2 (enExample) |
| WO (1) | WO2015081437A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3865580A1 (en) | 2013-03-15 | 2021-08-18 | The Board of Trustees of the Leland Stanford Junior University | Benzylisoquinoline alkaloids (bia) producing microbes, and methods of making and using the same |
| WO2015066642A1 (en) | 2013-11-04 | 2015-05-07 | The Board Of Trustees Of The Leland Stanford Junior University | Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same |
| WO2015081437A1 (en) * | 2013-12-04 | 2015-06-11 | Epimeron Inc. | Compositions and methods for making (r)-reticuline and precursors thereof |
| CA2946812C (en) * | 2014-05-16 | 2023-10-10 | The Unversity Of York | Cytochrome p450 fusion protein |
| CN107614688B (zh) | 2015-05-04 | 2023-02-28 | 小利兰·斯坦福大学托管委员会 | 产生苄基异喹啉生物碱(bia)前体的微生物及其制备和使用方法 |
| ES2945359T3 (es) * | 2015-05-08 | 2023-06-30 | Univ Leland Stanford Junior | Métodos para producir epimerasas y alcaloides de bencilisoquinolina |
| GB201511156D0 (en) * | 2015-06-24 | 2015-08-05 | Glaxosmithkline Australia Pty Ltd And University Of York | Production of alkaloids |
| CA3028817A1 (en) | 2016-06-27 | 2018-01-04 | Serturner Corp. | Polynucleotides and polypeptides useful for making alkaloid compounds |
| CA3029263A1 (en) | 2016-06-27 | 2018-01-04 | Intrexon Corporation | Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof |
| CN106119265B (zh) * | 2016-06-30 | 2019-04-30 | 湖南美可达生物资源股份有限公司 | 博落回中参与血根碱与白屈菜红碱合成的细胞色素p450酶基因及其应用 |
| EP3529355A4 (en) | 2016-10-18 | 2020-07-08 | Antheia, Inc. | PROCESSES FOR THE PRODUCTION OF NOR-OPIOID AND NAL-OPIOID BENZYLISOQUINOLINE ALKALOIDS |
| GB2579940B (en) | 2017-08-03 | 2022-11-30 | Antheia Inc | Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids |
| IL276462B2 (en) | 2018-02-08 | 2026-03-01 | Antheia Inc | Methods for producing morphine alkaloids and derivatives |
| WO2020185626A1 (en) | 2019-03-08 | 2020-09-17 | The Board Of Trustees Of The Leland Stanford Junior University | Tropane alkaloid (ta) producing non-plant host cells, and methods of making and using the same |
| US12359233B2 (en) | 2019-06-24 | 2025-07-15 | Fermelanta, Inc. | Production method of (R)-reticuline |
| WO2024100063A1 (en) | 2022-11-08 | 2024-05-16 | River Stone Biotech Aps | Genetically modified benzylisoquinoline alkaloid-producing host cells with modified efflux transporter gene expression |
| CN119776567A (zh) * | 2024-12-16 | 2025-04-08 | 广西壮族自治区农业科学院 | 鉴定番荔枝种质资源的分子标记引物试剂盒及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3785927A (en) | 1973-02-12 | 1974-01-15 | Merck & Co Inc | Process for converting(-)reticuline to(+)salutaridine |
| GB1408729A (en) * | 1973-08-13 | 1975-10-01 | Lilly Co Eli | Sulphilimine compounds |
| US5268463A (en) | 1986-11-11 | 1993-12-07 | Jefferson Richard A | Plant promoter α-glucuronidase gene construct |
| AUPP946399A0 (en) * | 1999-03-26 | 1999-04-22 | Johnson & Johnson Research Pty. Limited | Codeinone reductase from alkaloid poppy |
| WO2005033305A1 (ja) * | 2003-09-17 | 2005-04-14 | Kyoto University | ＲＮＡｉ法を用いた有用アルカロイド生合成中間体の生産法 |
| EP1837396A1 (en) * | 2006-03-23 | 2007-09-26 | Institut für Pflanzenbiochemie-IPB | Salutaridine reductase and morphine biosynthesis |
| WO2008067070A2 (en) * | 2006-10-19 | 2008-06-05 | California Institute Of Technology | Compositions and methods for producing benzylisoquinolines alkaloids |
| WO2011058446A2 (en) | 2009-11-12 | 2011-05-19 | Uti Limited Partnership | Thebaine 6-o-demethylase and codeine o-demethylase from papaver somniferum |
| WO2015081437A1 (en) * | 2013-12-04 | 2015-06-11 | Epimeron Inc. | Compositions and methods for making (r)-reticuline and precursors thereof |
| US20160340704A1 (en) | 2014-01-13 | 2016-11-24 | Valorbec Société en Commandite | Method of making a benzylisoquinoline alkaloid (bia) metabolite, enzymes therefore |
| CA2946812C (en) * | 2014-05-16 | 2023-10-10 | The Unversity Of York | Cytochrome p450 fusion protein |
| ES2945359T3 (es) | 2015-05-08 | 2023-06-30 | Univ Leland Stanford Junior | Métodos para producir epimerasas y alcaloides de bencilisoquinolina |
-
2014
- 2014-12-03 WO PCT/CA2014/051164 patent/WO2015081437A1/en not_active Ceased
- 2014-12-03 CN CN202210963307.6A patent/CN115927140A/zh active Pending
- 2014-12-03 EP EP14867017.7A patent/EP3077513B1/en active Active
- 2014-12-03 US US15/101,474 patent/US10190141B2/en active Active
- 2014-12-03 CA CA2932448A patent/CA2932448C/en active Active
- 2014-12-03 JP JP2016536954A patent/JP6783655B2/ja active Active
- 2014-12-03 RU RU2016124228A patent/RU2729065C2/ru active
- 2014-12-03 CN CN202210963296.1A patent/CN115927139A/zh active Pending
- 2014-12-03 ES ES14867017T patent/ES2961516T3/es active Active
- 2014-12-03 MX MX2016007176A patent/MX364825B/es active IP Right Grant
- 2014-12-03 EP EP23188492.5A patent/EP4289959B1/en active Active
- 2014-12-03 AU AU2014360597A patent/AU2014360597B2/en active Active
- 2014-12-03 KR KR1020167017344A patent/KR102018240B1/ko active Active
- 2014-12-03 DK DK14867017.7T patent/DK3077513T5/da active
- 2014-12-03 KR KR1020197025315A patent/KR102491060B1/ko active Active
- 2014-12-03 BR BR112016012595-9A patent/BR112016012595B1/pt active IP Right Grant
- 2014-12-03 CN CN201480071559.1A patent/CN105980563B/zh active Active
-
2016
- 2016-06-01 IL IL245970A patent/IL245970B/en active IP Right Grant
-
2018
- 2018-12-07 US US16/213,037 patent/US11613770B2/en active Active
-
2019
- 2019-12-09 IL IL271289A patent/IL271289B/en unknown
-
2020
- 2020-01-08 AU AU2020200131A patent/AU2020200131A1/en not_active Abandoned
- 2020-03-10 AU AU2020201743A patent/AU2020201743B2/en active Active
-
2022
- 2022-11-29 AU AU2022279419A patent/AU2022279419B2/en active Active
-
2023
- 2023-03-06 US US18/179,035 patent/US20240002894A1/en active Pending
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