JP2013533745A5 - - Google Patents
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- Publication number
- JP2013533745A5 JP2013533745A5 JP2013518791A JP2013518791A JP2013533745A5 JP 2013533745 A5 JP2013533745 A5 JP 2013533745A5 JP 2013518791 A JP2013518791 A JP 2013518791A JP 2013518791 A JP2013518791 A JP 2013518791A JP 2013533745 A5 JP2013533745 A5 JP 2013533745A5
- Authority
- JP
- Japan
- Prior art keywords
- norovirus
- chimeric
- strain
- vlp
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001263478 Norovirus Species 0.000 claims description 74
- 108090000623 proteins and genes Proteins 0.000 claims description 46
- 102000004169 proteins and genes Human genes 0.000 claims description 36
- 210000004027 cell Anatomy 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 14
- 108020004707 nucleic acids Proteins 0.000 claims description 13
- 102000039446 nucleic acids Human genes 0.000 claims description 13
- 150000007523 nucleic acids Chemical class 0.000 claims description 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 230000002163 immunogen Effects 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 239000001963 growth medium Substances 0.000 claims description 3
- 241000271566 Aves Species 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 241000238631 Hexapoda Species 0.000 claims description 2
- 241000714209 Norwalk virus Species 0.000 claims description 2
- 241000509413 Snow Mountain virus Species 0.000 claims description 2
- 241000223892 Tetrahymena Species 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 210000005253 yeast cell Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36158110P | 2010-07-06 | 2010-07-06 | |
| US61/361,581 | 2010-07-06 | ||
| PCT/US2011/042979 WO2012006293A1 (en) | 2010-07-06 | 2011-07-05 | Norovirus derived immunogenic compositions and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016000962A Division JP6351641B2 (ja) | 2010-07-06 | 2016-01-06 | ノロウイルスに由来する免疫原性組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013533745A JP2013533745A (ja) | 2013-08-29 |
| JP2013533745A5 true JP2013533745A5 (enExample) | 2014-08-14 |
Family
ID=44628871
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518791A Pending JP2013533745A (ja) | 2010-07-06 | 2011-07-05 | ノロウイルスに由来する免疫原性組成物および方法 |
| JP2016000962A Active JP6351641B2 (ja) | 2010-07-06 | 2016-01-06 | ノロウイルスに由来する免疫原性組成物および方法 |
| JP2018030649A Withdrawn JP2018086020A (ja) | 2010-07-06 | 2018-02-23 | ノロウイルスに由来する免疫原性組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016000962A Active JP6351641B2 (ja) | 2010-07-06 | 2016-01-06 | ノロウイルスに由来する免疫原性組成物および方法 |
| JP2018030649A Withdrawn JP2018086020A (ja) | 2010-07-06 | 2018-02-23 | ノロウイルスに由来する免疫原性組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20130171185A1 (enExample) |
| EP (2) | EP3153578A1 (enExample) |
| JP (3) | JP2013533745A (enExample) |
| CN (1) | CN103154242B (enExample) |
| AU (1) | AU2011276328C1 (enExample) |
| CA (1) | CA2804501C (enExample) |
| MX (1) | MX2013000163A (enExample) |
| WO (1) | WO2012006293A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE047796T2 (hu) | 2010-07-06 | 2020-05-28 | Glaxosmithkline Biologicals Sa | RNS bevitele több immunútvonal bekapcsolására |
| EP2591114B1 (en) | 2010-07-06 | 2016-06-08 | GlaxoSmithKline Biologicals SA | Immunisation of large mammals with low doses of rna |
| PT2590626E (pt) | 2010-07-06 | 2016-01-26 | Glaxosmithkline Biolog Sa | Lipossomas com lípidos que têm um valor de pka vantajoso para administração de arn |
| HUE058361T2 (hu) | 2010-08-31 | 2022-07-28 | Glaxosmithkline Biologicals Sa | Pegilált liposzómák immunogént kódoló RNA bejuttatására |
| ES2945135T3 (es) | 2010-10-11 | 2023-06-28 | Glaxosmithkline Biologicals Sa | Plataformas de suministro de antígenos |
| EP3854413A1 (en) * | 2011-07-06 | 2021-07-28 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
| RU2015132962A (ru) * | 2013-01-10 | 2017-02-14 | Новартис Аг | Иммуногенные композиции на основе вируса гриппа и их применение |
| US9975923B2 (en) * | 2013-03-15 | 2018-05-22 | The University Of North Carolina At Chapel Hill | Methods and compositions for norovirus blockade epitopes |
| EP2970395A4 (en) * | 2013-03-15 | 2017-03-29 | The University of North Carolina At Chapel Hill | Methods and compositions for norovirus blockade epitopes |
| TW201629090A (zh) * | 2014-08-07 | 2016-08-16 | 基亞生物科技股份有限公司 | 類病毒顆粒疫苗 |
| KR102773575B1 (ko) * | 2015-06-12 | 2025-02-27 | 박사르트, 인크. | Rsv 및 노로바이러스 항원들의 소장 내의 전달을 위한 제형들 |
| CN107034198B (zh) | 2015-07-15 | 2021-03-09 | 长春百克生物科技股份公司 | 一种嵌合诺如病毒p颗粒及其制备和应用 |
| KR101914779B1 (ko) | 2016-03-18 | 2018-11-02 | (주)인테라 | 노로 바이러스 백신을 생산하기 위한 재조합 발현 벡터 |
| WO2017160124A2 (ko) * | 2016-03-18 | 2017-09-21 | 연세대학교 산학협력단 | 노로 바이러스 백신을 생산하기 위한 재조합 발현 벡터 |
| EP3452493B1 (en) * | 2016-05-04 | 2025-01-15 | CureVac SE | Nucleic acid molecules and uses thereof |
| WO2017214557A1 (en) | 2016-06-10 | 2017-12-14 | Counsyl, Inc. | Nucleic acid sequencing adapters and uses thereof |
| EP3518974A4 (en) | 2016-09-29 | 2020-05-27 | Myriad Women's Health, Inc. | NON-INVASIVE PRENATAL SCREENING USING DYNAMIC ITERATIVE DEEP OPTIMIZATION |
| WO2018144217A1 (en) | 2017-01-31 | 2018-08-09 | Counsyl, Inc. | Methods and compositions for enrichment of target polynucleotides |
| US10968447B2 (en) | 2017-01-31 | 2021-04-06 | Myriad Women's Health, Inc. | Methods and compositions for enrichment of target polynucleotides |
| CA3056812C (en) * | 2017-03-23 | 2022-11-29 | Medicago Inc. | Norovirus fusion proteins and vlps comprising norovirus fusion proteins |
| US11232850B2 (en) | 2017-03-24 | 2022-01-25 | Myriad Genetics, Inc. | Copy number variant caller |
| WO2018182983A1 (en) * | 2017-03-28 | 2018-10-04 | Children's Hospital Medical Center | Norovirus s particle based vaccines and methods of making and using same |
| PH12020550732A1 (en) | 2017-11-30 | 2021-04-19 | Medicago Inc | Modified norovirus vp1 proteins and vlps comprising modified norovirus vp1 proteins |
| JP6713013B2 (ja) * | 2018-03-06 | 2020-06-24 | 株式会社イーダブルニュートリション・ジャパン | 貝類のノロウイルス不活化方法 |
| WO2020010428A1 (en) * | 2018-07-13 | 2020-01-16 | Medicago Inc. | Modified norovirus vp1 proteins and vlps comprising modified norovirus vp1 proteins |
| MX2021011059A (es) * | 2019-03-12 | 2021-10-13 | Icon Genetics Gmbh | Particulas tipo norovirus con estabilidad mejorada. |
| BR112022013537A2 (pt) * | 2020-01-08 | 2022-11-22 | Bharat Biotech Int Ltd | Composições de vacina viral e métodos de preparações das mesmas |
| CN114316033A (zh) * | 2020-09-29 | 2022-04-12 | 香港理工大学深圳研究院 | 一种特异性识别诺如病毒的单克隆抗体及制备方法与应用 |
| CN115161343B (zh) * | 2021-04-01 | 2024-06-04 | 苏州相奕生物技术有限公司 | 一种重组腺病毒表达载体及以其制备的多价诺如病毒疫苗 |
| MX2024005194A (es) * | 2021-10-27 | 2024-07-22 | Univ Pennsylvania | Vacuna de norovirus y métodos de su uso. |
| CN118871591A (zh) | 2022-03-18 | 2024-10-29 | 电化株式会社 | 包含通过接头连接的衣壳蛋白的病毒样颗粒 |
| WO2024144272A1 (ko) * | 2022-12-27 | 2024-07-04 | (주)한국바이오셀프 | 노로바이러스 gii mrna를 포함하는 백신 조성물 |
| WO2024144262A1 (ko) * | 2022-12-27 | 2024-07-04 | (주)한국바이오셀프 | 노로바이러스 gi mrna를 포함하는 백신 조성물 |
| CN118126202B (zh) * | 2024-05-07 | 2024-07-30 | 上海瑞宙生物科技有限公司 | 一种诺如病毒类病毒颗粒及其应用 |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0114787B1 (de) | 1983-01-25 | 1991-09-25 | Ciba-Geigy Ag | Neue Peptidderivate |
| US6090406A (en) | 1984-04-12 | 2000-07-18 | The Liposome Company, Inc. | Potentiation of immune responses with liposomal adjuvants |
| US5916588A (en) | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| CA1324969C (en) | 1988-05-06 | 1993-12-07 | Jeffrey R. Shuster | High level expression of proteins in yeast |
| AU627226B2 (en) | 1988-08-25 | 1992-08-20 | Liposome Company, Inc., The | Influenza vaccine and novel adjuvants |
| US6572862B1 (en) | 1989-11-08 | 2003-06-03 | Baylor College Of Medicine | Methods and reagents to detect and characterize Norwalk and related viruses |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| US5340740A (en) | 1992-05-15 | 1994-08-23 | North Carolina State University | Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process |
| ATE156710T1 (de) | 1992-06-25 | 1997-08-15 | Smithkline Beecham Biolog | Adjuvantien enthaltende impfstoffzusammensetzung |
| JPH08500250A (ja) | 1992-09-07 | 1996-01-16 | ベイラー・カレッジ・オブ・メディシン | ノーウォークおよび関連ウイルスを検出し、かつ特徴付けるための方法並びに試薬 |
| NZ263538A (en) | 1993-03-23 | 1996-10-28 | Smithkline Beecham Biolog | Vaccine compositions of 3-o-deacylated monophosphoryl lipid a |
| GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| FR2726003B1 (fr) | 1994-10-21 | 2002-10-18 | Agronomique Inst Nat Rech | Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| CA2283557A1 (en) | 1997-03-10 | 1998-09-17 | Heather L. Davis | Use of nucleic acids containing unmethylated cpg dinucleotide as an adjuvant |
| US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| US6348450B1 (en) | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
| CA2302554C (en) | 1997-09-05 | 2007-04-10 | Smithkline Beecham Biologicals S.A. | Oil in water emulsions containing saponins |
| GB9725084D0 (en) | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
| NZ504894A (en) | 1997-12-02 | 2002-12-20 | Powderject Vaccines Inc | Crystalline vaccine and adjuvant compositions jointly and separately administered to animals using a transdermal or transmucosally delivery technique |
| FR2771751B1 (fr) | 1997-12-03 | 2000-05-26 | Assist Publ Hopitaux De Paris | Erythrovirus et ses applications |
| WO1999040936A2 (en) | 1998-02-12 | 1999-08-19 | American Cyanamid Company | Pneumococcal and meningococcal vaccines formulated with interleukin-12 |
| US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
| AU746163B2 (en) | 1998-04-09 | 2002-04-18 | Smithkline Beecham Biologicals (Sa) | Adjuvant compositions |
| US6562798B1 (en) | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
| EP1797896A1 (en) | 1998-10-16 | 2007-06-20 | GlaxoSmithKline Biologicals SA | Adjuvant systems and vaccines |
| CA2348382C (en) | 1998-11-10 | 2013-09-17 | The University Of North Carolina At Chapel Hill | Chimeric parvovirus vectors and methods of making and administering the same |
| WO2000079280A1 (en) | 1999-06-22 | 2000-12-28 | Japan As Represented By Director-General National Institute Of Infectious Diseases | Srsv detection kit |
| AR025749A1 (es) | 1999-09-24 | 2002-12-11 | Smithkline Beecham Biolog | Vacunas |
| JP2003509473A (ja) | 1999-09-24 | 2003-03-11 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ワクチン |
| WO2001095935A1 (en) | 2000-01-20 | 2001-12-20 | Ottawa Health Research Institute | Immunostimulatory nucleic acids for inducing a th2 immune response |
| ES2256265T3 (es) | 2000-06-01 | 2006-07-16 | University Of North Carolina At Chapel Hill | Vectores de parvovirus duplicados. |
| SI1354204T2 (sl) | 2000-06-15 | 2010-09-30 | Novartis Vaccines & Diagnostic | Hcv antigen antitelo kombinacijska analiza |
| JP2002020399A (ja) | 2000-07-10 | 2002-01-23 | Osaka Prefecture | ノルウォークウイルス（ｎｖ）を認識するモノクローナル抗体 |
| KR100894767B1 (ko) | 2000-09-26 | 2009-04-24 | 이데라 파마슈티칼즈, 인코포레이티드 | 화학적인 위치 변화에 의해 면역자극 올리고누클레오티드유사체의 면역자극 활성을 조절하는 방법 |
| EP1372708B1 (en) | 2001-02-13 | 2008-06-18 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE ARMY | Vaccine for transcutaneous immunization against travellers' diarrhoea |
| EP2316482A1 (en) | 2001-03-19 | 2011-05-04 | Intercell USA, Inc. | Transcutaneous immunostimulation |
| GB0123580D0 (en) | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
| GB0123756D0 (en) | 2001-10-03 | 2001-11-21 | King S College London | A novel chaperone-type of adjuvant for vaccination - Basic 1 |
| WO2003035836A2 (en) | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
| FR2832423B1 (fr) | 2001-11-22 | 2004-10-08 | Vivalis | Systeme d'expression de proteines exogenes dans un systeme aviaire |
| AU2003215193A1 (en) | 2002-02-11 | 2003-09-04 | Joseph D. Mosca | Production of a protein delivery system for in vivo therapeutic treatment |
| FR2836924B1 (fr) | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| US6919426B2 (en) | 2002-09-19 | 2005-07-19 | Amgen Inc. | Peptides and related molecules that modulate nerve growth factor activity |
| WO2005032457A2 (en) | 2003-07-21 | 2005-04-14 | Boyce Thompson Institute For Plant Research, Inc. | Vectors and methods for immunization against norwalk virus using transgenic plants |
| EP1500699A1 (en) | 2003-07-22 | 2005-01-26 | Vivalis | Production of vaccinia virus with adherent or non adherent avian cell lines |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| US20050152911A1 (en) | 2003-09-24 | 2005-07-14 | Montana State University | Norovirus monoclonal antibodies and peptides |
| EP1528101A1 (en) | 2003-11-03 | 2005-05-04 | ProBioGen AG | Immortalized avian cell lines for virus production |
| PT1751289E (pt) | 2004-05-18 | 2009-03-31 | Alphavax Inc | Vectores de alfavirais derivados da tc-83, partículas e métodos |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| WO2007053188A2 (en) | 2005-06-01 | 2007-05-10 | Dow Global Technologies, Inc. | Production of multivalent virus like particles |
| WO2007081447A2 (en) * | 2005-11-22 | 2007-07-19 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and sapovirus antigens |
| EP1979485A2 (en) | 2006-01-31 | 2008-10-15 | The Board Of Trustees Of The Leland Stanford Junior University | Self-complementary parvoviral vectors, and methods for making and using the same |
| WO2008145400A2 (en) | 2007-05-31 | 2008-12-04 | Medigene Ag | Mutated structural protein of a parvovirus |
| US10130696B2 (en) * | 2007-09-18 | 2018-11-20 | Takeda Vaccines, Inc. | Method of conferring a protective immune response to norovirus |
| CN101153341B (zh) * | 2007-09-21 | 2010-12-15 | 珠海市疾病预防控制中心 | 诺如病毒gⅱ型检测用引物、检测方法、检测试剂盒 |
| ES2546213T3 (es) | 2008-03-03 | 2015-09-21 | Novartis Ag | Compuestos y composiciones como moduladores de la actividad de TLR |
| CA2730083C (en) | 2008-07-11 | 2016-11-01 | The Administrators Of The Tulane Educational Fund | Stimulus-responsive apta-chelamers |
| EP2324113B8 (en) * | 2008-08-08 | 2018-04-04 | Takeda Vaccines, Inc. | Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity |
| PL2853545T3 (pl) | 2008-09-17 | 2016-12-30 | Przeciwciało swoiste wobec IgE | |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子 |
| MY159483A (en) | 2008-11-26 | 2017-01-13 | Amgen Inc | Variants of activin iib receptor polypeptides and uses thereof |
-
2011
- 2011-07-05 CA CA2804501A patent/CA2804501C/en active Active
- 2011-07-05 US US13/808,157 patent/US20130171185A1/en not_active Abandoned
- 2011-07-05 EP EP16199523.8A patent/EP3153578A1/en not_active Ceased
- 2011-07-05 EP EP11735734.3A patent/EP2591097A1/en not_active Withdrawn
- 2011-07-05 WO PCT/US2011/042979 patent/WO2012006293A1/en not_active Ceased
- 2011-07-05 CN CN201180042647.5A patent/CN103154242B/zh active Active
- 2011-07-05 JP JP2013518791A patent/JP2013533745A/ja active Pending
- 2011-07-05 AU AU2011276328A patent/AU2011276328C1/en active Active
- 2011-07-05 MX MX2013000163A patent/MX2013000163A/es unknown
-
2015
- 2015-11-19 US US14/946,324 patent/US10065994B2/en active Active
-
2016
- 2016-01-06 JP JP2016000962A patent/JP6351641B2/ja active Active
-
2018
- 2018-02-23 JP JP2018030649A patent/JP2018086020A/ja not_active Withdrawn
- 2018-08-02 US US16/053,399 patent/US10287324B2/en active Active
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