CN1859923B - Hpv 45 l1在酵母中的优化表达 - Google Patents

Hpv 45 l1在酵母中的优化表达 Download PDF

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Publication number
CN1859923B
CN1859923B CN2004800281067A CN200480028106A CN1859923B CN 1859923 B CN1859923 B CN 1859923B CN 2004800281067 A CN2004800281067 A CN 2004800281067A CN 200480028106 A CN200480028106 A CN 200480028106A CN 1859923 B CN1859923 B CN 1859923B
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hpv
protein
yeast
vlps
hpv45l1
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Expired - Lifetime
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Chinese (zh)
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CN1859923A (zh
Inventor
J·T·布赖恩
M·K·布朗罗
L·D·舒尔茨
K·U·扬森
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Merck Sharp and Dohme BV
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Merck Sharp and Dohme LLC
Merck and Co Inc
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN2004800281067A 2003-09-29 2004-09-24 Hpv 45 l1在酵母中的优化表达 Expired - Lifetime CN1859923B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50681203P 2003-09-29 2003-09-29
US60/506,812 2003-09-29
PCT/US2004/031326 WO2005032586A1 (en) 2003-09-29 2004-09-24 Optimized expression of hpv 45 l1 in yeast

Publications (2)

Publication Number Publication Date
CN1859923A CN1859923A (zh) 2006-11-08
CN1859923B true CN1859923B (zh) 2012-09-05

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CN2004800281067A Expired - Lifetime CN1859923B (zh) 2003-09-29 2004-09-24 Hpv 45 l1在酵母中的优化表达

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US (2) US7250170B2 (enExample)
EP (1) EP1673106B1 (enExample)
JP (4) JP5451960B2 (enExample)
KR (1) KR101165278B1 (enExample)
CN (1) CN1859923B (enExample)
AR (2) AR045804A1 (enExample)
AT (1) ATE435029T1 (enExample)
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BE (1) BE2015C072I2 (enExample)
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CN109321592A (zh) * 2012-01-21 2019-02-12 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv18 l1蛋白的方法
CN108624614A (zh) * 2012-03-28 2018-10-09 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv11 l1蛋白的方法
CN110484554B (zh) * 2013-04-26 2024-04-16 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv52 l1蛋白的方法
CN104120088B (zh) * 2013-04-26 2019-09-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv58 l1蛋白的方法
CN110295190A (zh) * 2013-05-17 2019-10-01 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv45 l1蛋白的方法
CN112280792B (zh) * 2013-09-29 2022-06-24 上海泽润生物科技有限公司 人乳头瘤病毒基因，及载体，菌株，表达方法
EP3057612B1 (en) 2013-10-16 2020-05-06 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
EA201790365A1 (ru) * 2014-09-11 2017-07-31 Кадила Хелзкэр Лимитед Антигены вируса папилломы человека с хорошими иммунологическими свойствами и содержащая их вакцина
CN106282278B (zh) * 2015-06-29 2021-06-08 广东东阳光药业有限公司 一种人乳头瘤病毒l1蛋白的发酵方法
CN106701798B (zh) * 2015-08-12 2021-09-17 北京康乐卫士生物技术股份有限公司 45型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN109750050B (zh) * 2017-11-07 2023-08-18 上海泽润生物科技有限公司 重组人乳头瘤病毒45亚型蛋白表达
US11638754B2 (en) 2020-02-14 2023-05-02 Merck Sharp & Dohme Llc HPV vaccine
CN112680462B (zh) * 2020-12-29 2022-02-22 上海博唯生物科技有限公司 一种人乳头瘤病毒35型/hpv35型l1/l2及其制备与应用
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
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Publication number Publication date
NO339932B1 (no) 2017-02-20
WO2005032586A1 (en) 2005-04-14
RU2360001C2 (ru) 2009-06-27
MXPA06003457A (es) 2006-06-05
IL174458A (en) 2014-06-30
HUS1500063I1 (hu) 2016-02-29
LU92902I2 (fr) 2016-03-08
US20080138361A1 (en) 2008-06-12
CY2015050I2 (el) 2016-06-22
MY140664A (en) 2010-01-15
PT1673106E (pt) 2009-09-22
NO20061876L (no) 2006-04-28
JP2011152137A (ja) 2011-08-11
NO2017012I1 (no) 2017-04-05
ZA200601961B (en) 2007-05-30
RU2006114701A (ru) 2007-11-10
TWI350853B (en) 2011-10-21
DE602004021828D1 (de) 2009-08-13
BRPI0414845A (pt) 2006-11-21
AR045804A1 (es) 2005-11-16
NL300776I1 (enExample) 2015-12-29
ATE435029T1 (de) 2009-07-15
CY1110525T1 (el) 2015-04-29
US7482015B2 (en) 2009-01-27
SI1673106T1 (sl) 2009-12-31
NZ545834A (en) 2009-02-28
AU2004277934A1 (en) 2005-04-14
LTPA2015049I1 (lt) 2016-01-11
JP2016136947A (ja) 2016-08-04
CA2539168C (en) 2011-05-31
KR101165278B1 (ko) 2012-07-23
TW200521233A (en) 2005-07-01
AR077396A2 (es) 2011-08-24
US7250170B2 (en) 2007-07-31
CA2539168A1 (en) 2005-04-14
US20060240040A1 (en) 2006-10-26
BRPI0414845B1 (pt) 2020-10-13
CN1859923A (zh) 2006-11-08
ES2327530T3 (es) 2009-10-30
JP5451960B2 (ja) 2014-03-26
IL174458A0 (en) 2006-08-01
JP2007507207A (ja) 2007-03-29
LTC1673106I2 (lt) 2017-05-10
AU2004277934B2 (en) 2009-09-17
BRPI0414845B8 (pt) 2021-06-15
FR15C0083I1 (fr) 2016-08-01
JP2014221052A (ja) 2014-11-27
DK1673106T3 (da) 2009-11-09
FR15C0083I2 (fr) 2016-11-25
NO2022051I1 (no) 2022-11-30
EP1673106B1 (en) 2009-07-01
NL300776I2 (enExample) 2015-12-29
BE2015C072I2 (enExample) 2023-12-14
IS8362A (is) 2006-03-20
CY2015050I1 (el) 2016-06-22
PL1673106T3 (pl) 2009-12-31
EP1673106A1 (en) 2006-06-28
KR20070029628A (ko) 2007-03-14
IS2694B (is) 2010-11-15

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