JP2014508541A5 - - Google Patents
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- Publication number
- JP2014508541A5 JP2014508541A5 JP2014501294A JP2014501294A JP2014508541A5 JP 2014508541 A5 JP2014508541 A5 JP 2014508541A5 JP 2014501294 A JP2014501294 A JP 2014501294A JP 2014501294 A JP2014501294 A JP 2014501294A JP 2014508541 A5 JP2014508541 A5 JP 2014508541A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- activity
- isobutanol
- recombinant host
- heterologous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 25
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 21
- 230000000694 effects Effects 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 108010000200 Ketol-acid reductoisomerase Proteins 0.000 claims 11
- 108090000790 Enzymes Proteins 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- WTLNOANVTIKPEE-UHFFFAOYSA-N 2-acetyloxypropanoic acid Chemical compound OC(=O)C(C)OC(C)=O WTLNOANVTIKPEE-UHFFFAOYSA-N 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- JTEYKUFKXGDTEU-UHFFFAOYSA-N 2,3-dihydroxy-3-methylbutanoic acid Chemical compound CC(C)(O)C(O)C(O)=O JTEYKUFKXGDTEU-UHFFFAOYSA-N 0.000 claims 2
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 2
- 241000193403 Clostridium Species 0.000 claims 2
- 241000235648 Pichia Species 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- AOWPAWLEXIYETE-UHFFFAOYSA-N 2,3-Dihydroxy-2-methylbutanoic acid Chemical compound CC(O)C(C)(O)C(O)=O AOWPAWLEXIYETE-UHFFFAOYSA-N 0.000 claims 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 1
- 241000186014 Bifidobacterium angulatum Species 0.000 claims 1
- 241000186020 Bifidobacterium dentium Species 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 101100351264 Candida albicans (strain SC5314 / ATCC MYA-2876) PDC11 gene Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 101710088194 Dehydrogenase Proteins 0.000 claims 1
- 102100028121 Fos-related antigen 2 Human genes 0.000 claims 1
- 101001059934 Homo sapiens Fos-related antigen 2 Proteins 0.000 claims 1
- 101150050255 PDC1 gene Proteins 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- 108010011939 Pyruvate Decarboxylase Proteins 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 101100082596 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDC5 gene Proteins 0.000 claims 1
- 101100519200 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDC6 gene Proteins 0.000 claims 1
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- 241000588902 Zymomonas mobilis Species 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 210000000172 cytosol Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N glycerol 1-phosphate Chemical compound OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 239000012074 organic phase Substances 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161467271P | 2011-03-24 | 2011-03-24 | |
| US201161467249P | 2011-03-24 | 2011-03-24 | |
| US201161467261P | 2011-03-24 | 2011-03-24 | |
| US61/467,261 | 2011-03-24 | ||
| US61/467,249 | 2011-03-24 | ||
| US61/467,271 | 2011-03-24 | ||
| US201161472484P | 2011-04-06 | 2011-04-06 | |
| US201161472497P | 2011-04-06 | 2011-04-06 | |
| US201161472474P | 2011-04-06 | 2011-04-06 | |
| US201161472487P | 2011-04-06 | 2011-04-06 | |
| US61/472,474 | 2011-04-06 | ||
| US61/472,487 | 2011-04-06 | ||
| US61/472,497 | 2011-04-06 | ||
| US61/472,484 | 2011-04-06 | ||
| US201161570513P | 2011-12-14 | 2011-12-14 | |
| US61/570,513 | 2011-12-14 | ||
| PCT/US2012/030479 WO2012129555A2 (en) | 2011-03-24 | 2012-03-23 | Host cells and methods for production of isobutanol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508541A JP2014508541A (ja) | 2014-04-10 |
| JP2014508541A5 true JP2014508541A5 (enExample) | 2015-05-07 |
| JP6099623B2 JP6099623B2 (ja) | 2017-03-22 |
Family
ID=46880082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501294A Active JP6099623B2 (ja) | 2011-03-24 | 2012-03-23 | イソブタノール生成のための宿主細胞及び方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9790521B2 (enExample) |
| EP (1) | EP2689014B1 (enExample) |
| JP (1) | JP6099623B2 (enExample) |
| KR (1) | KR20140092759A (enExample) |
| CN (1) | CN103827304B (enExample) |
| AR (1) | AR088778A1 (enExample) |
| AU (2) | AU2012230737B2 (enExample) |
| BR (1) | BR112013024328A2 (enExample) |
| CA (1) | CA2831130C (enExample) |
| HU (1) | HUE045191T2 (enExample) |
| MX (1) | MX347976B (enExample) |
| WO (1) | WO2012129555A2 (enExample) |
| ZA (1) | ZA201306708B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| KR101573775B1 (ko) | 2007-04-18 | 2015-12-04 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산 |
| US8188250B2 (en) * | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| KR20110063576A (ko) | 2008-09-29 | 2011-06-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 효모에서 증가된 이종성 Ｆｅ-Ｓ 효소 활성 |
| CN102762722B (zh) | 2009-12-29 | 2015-05-20 | 布特马斯先进生物燃料有限责任公司 | 用于发酵生产低级烷基醇的醇脱氢酶(adh) |
| RU2012138943A (ru) | 2010-02-12 | 2014-03-20 | Джево, Инк. | Дрожжевые микроорганизмы с пониженным накоплением побочных продуктов для улучшенного производства топлив, химикатов и аминокислот |
| US9297016B2 (en) | 2010-02-17 | 2016-03-29 | Butamax Advanced Biofuels Llc | Activity of Fe—S cluster requiring proteins |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| EP3269806B1 (en) | 2010-09-07 | 2020-05-27 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
| CA2831130C (en) | 2011-03-24 | 2021-10-26 | Butamax (Tm) Advanced Biofuels Llc | Host cells and methods for production of isobutanol |
| US20120258873A1 (en) * | 2011-04-06 | 2012-10-11 | Butamax(Tm) Advanced Biofuels Llc | Reduction of 2,3-dihydroxy-2-methyl butyrate (dhmb) in butanol production |
| JP6093764B2 (ja) * | 2011-07-28 | 2017-03-08 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ケトイソ吉草酸デカルボキシラーゼ酵素およびその使用方法 |
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| CN104284981A (zh) | 2012-03-23 | 2015-01-14 | 布特马斯先进生物燃料有限责任公司 | 在针对产丁醇生物的培养基中补充乙酸盐 |
| WO2013176909A2 (en) | 2012-05-11 | 2013-11-28 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| BR112015003701A2 (pt) | 2012-08-22 | 2017-12-12 | Butamax Advanced Biofuels Llc | células hospedeiras recombinantes, método para aprimoramento, processo para a produção de um álcool, polinucleotídeo isolado, cassete de expressão e composição |
| US9840724B2 (en) | 2012-09-21 | 2017-12-12 | Butamax Advanced Biofuels Llc | Production of renewable hydrocarbon compositions |
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| WO2014106107A2 (en) | 2012-12-28 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Dhad variants for butanol production |
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| WO2014144643A1 (en) | 2013-03-15 | 2014-09-18 | Butamax Advanced Biofuels Llc | Method for producing butanol using extractive fermentation |
| WO2014151190A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Dhad variants and methods of screening |
| CA2901374A1 (en) | 2013-03-15 | 2014-09-18 | Butamax Advanced Biofuels Llc | Method for production of butanol using extractive fermentation |
| WO2014151645A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Process for maximizing biomass growth and butanol yield by feedback control |
| US10294461B2 (en) | 2013-03-28 | 2019-05-21 | Kaneka Corporation | Modified carbonyl reducing enzyme and gene |
| WO2015002913A1 (en) | 2013-07-03 | 2015-01-08 | Butamax Advanced Biofuels Llc | Partial adaptation for butanol production |
| CN105722969A (zh) | 2013-10-28 | 2016-06-29 | 丹尼斯科美国公司 | 大规模基因工程化活性干酵母 |
| US20160376600A1 (en) | 2013-11-25 | 2016-12-29 | Genomatica, Inc. | Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol |
| PL3077501T3 (pl) | 2013-12-03 | 2022-01-31 | Genomatica, Inc. | Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa |
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| CN110177801B (zh) * | 2016-11-09 | 2024-02-23 | 丹尼斯科美国公司 | 具有改善的醇生产的酵母 |
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| CN111378681B (zh) * | 2018-12-27 | 2023-01-17 | 中国医学科学院药物研究所 | 生产达玛烯二醇-ii糖苷的重组菌及其应用 |
| CN111826405B (zh) * | 2019-04-16 | 2022-09-27 | 中国科学院大连化学物理研究所 | 一种生物催化还原丙酮酸产d-乳酸的方法 |
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| US20110195505A1 (en) | 2009-10-08 | 2011-08-11 | Butamax(Tm) Advanced Biofuels Llc | Bacterial strains for butanol production |
| BR112012012492A2 (pt) | 2009-11-24 | 2019-09-24 | Gevo Inc | métodos para aumentar atividade de diidróxi ácido desidratase para aperfeiçoar produção de combustíveis, produtos químicos e aminoácidos |
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| RU2012138943A (ru) | 2010-02-12 | 2014-03-20 | Джево, Инк. | Дрожжевые микроорганизмы с пониженным накоплением побочных продуктов для улучшенного производства топлив, химикатов и аминокислот |
| US9297016B2 (en) | 2010-02-17 | 2016-03-29 | Butamax Advanced Biofuels Llc | Activity of Fe—S cluster requiring proteins |
| BR112012031847A2 (pt) | 2010-06-17 | 2016-02-16 | Butamax Tm Advanced Biofuels | cultura de produção para a produção fermentativa de butanol, método de produção de butanol, método para a produção de butanol, método para aumentar a tolerância de uma cultura de produção para a produção fermentativa de butanol e cultura de produção para produção fermentativa de butanol |
| CN102947456A (zh) | 2010-06-18 | 2013-02-27 | 布特马斯先进生物燃料有限责任公司 | 补充脂肪酸以改善醇产量 |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
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| EP3269806B1 (en) * | 2010-09-07 | 2020-05-27 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
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| WO2013176909A2 (en) | 2012-05-11 | 2013-11-28 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| US9512408B2 (en) | 2012-09-26 | 2016-12-06 | Butamax Advanced Biofuels Llc | Polypeptides with ketol-acid reductoisomerase activity |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| US20140186911A1 (en) | 2012-12-28 | 2014-07-03 | Butamax Advanced Biofuels Llc | Recombinant host cells and methods for producing butanol |
| WO2014106107A2 (en) | 2012-12-28 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Dhad variants for butanol production |
| WO2014160050A1 (en) | 2013-03-14 | 2014-10-02 | Butamax Advanced Biofuels Llc | Glycerol 3- phosphate dehydrogenase for butanol production |
| WO2014151190A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Dhad variants and methods of screening |
-
2012
- 2012-03-23 CA CA2831130A patent/CA2831130C/en active Active
- 2012-03-23 AU AU2012230737A patent/AU2012230737B2/en active Active
- 2012-03-23 JP JP2014501294A patent/JP6099623B2/ja active Active
- 2012-03-23 WO PCT/US2012/030479 patent/WO2012129555A2/en not_active Ceased
- 2012-03-23 KR KR1020137027906A patent/KR20140092759A/ko not_active Ceased
- 2012-03-23 EP EP12760879.2A patent/EP2689014B1/en active Active
- 2012-03-23 US US13/428,585 patent/US9790521B2/en active Active
- 2012-03-23 MX MX2013010823A patent/MX347976B/es active IP Right Grant
- 2012-03-23 BR BR112013024328-7A patent/BR112013024328A2/pt not_active Application Discontinuation
- 2012-03-23 CN CN201280024903.2A patent/CN103827304B/zh not_active Expired - Fee Related
- 2012-03-23 HU HUE12760879A patent/HUE045191T2/hu unknown
- 2012-03-26 AR ARP120101001A patent/AR088778A1/es unknown
-
2013
- 2013-03-15 US US13/840,676 patent/US9422582B2/en active Active
- 2013-03-15 US US13/840,649 patent/US9422581B2/en active Active
- 2013-09-06 ZA ZA2013/06708A patent/ZA201306708B/en unknown
-
2017
- 2017-01-20 AU AU2017200439A patent/AU2017200439A1/en not_active Abandoned
- 2017-04-03 US US15/477,980 patent/US20170275652A1/en not_active Abandoned
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