JP2014508541A5 - - Google Patents
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- Publication number
- JP2014508541A5 JP2014508541A5 JP2014501294A JP2014501294A JP2014508541A5 JP 2014508541 A5 JP2014508541 A5 JP 2014508541A5 JP 2014501294 A JP2014501294 A JP 2014501294A JP 2014501294 A JP2014501294 A JP 2014501294A JP 2014508541 A5 JP2014508541 A5 JP 2014508541A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- activity
- isobutanol
- recombinant host
- heterologous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 25
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 21
- 230000000694 effects Effects 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 108010000200 Ketol-acid reductoisomerase Proteins 0.000 claims 11
- 108090000790 Enzymes Proteins 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- WTLNOANVTIKPEE-UHFFFAOYSA-N 2-acetyloxypropanoic acid Chemical compound OC(=O)C(C)OC(C)=O WTLNOANVTIKPEE-UHFFFAOYSA-N 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- JTEYKUFKXGDTEU-UHFFFAOYSA-N 2,3-dihydroxy-3-methylbutanoic acid Chemical compound CC(C)(O)C(O)C(O)=O JTEYKUFKXGDTEU-UHFFFAOYSA-N 0.000 claims 2
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 2
- 241000193403 Clostridium Species 0.000 claims 2
- 241000235648 Pichia Species 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- AOWPAWLEXIYETE-UHFFFAOYSA-N 2,3-Dihydroxy-2-methylbutanoic acid Chemical compound CC(O)C(C)(O)C(O)=O AOWPAWLEXIYETE-UHFFFAOYSA-N 0.000 claims 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 1
- 241000186014 Bifidobacterium angulatum Species 0.000 claims 1
- 241000186020 Bifidobacterium dentium Species 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 101100351264 Candida albicans (strain SC5314 / ATCC MYA-2876) PDC11 gene Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 101710088194 Dehydrogenase Proteins 0.000 claims 1
- 102100028121 Fos-related antigen 2 Human genes 0.000 claims 1
- 101001059934 Homo sapiens Fos-related antigen 2 Proteins 0.000 claims 1
- 101150050255 PDC1 gene Proteins 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- 108010011939 Pyruvate Decarboxylase Proteins 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 101100082596 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDC5 gene Proteins 0.000 claims 1
- 101100519200 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) PDC6 gene Proteins 0.000 claims 1
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- 241000588902 Zymomonas mobilis Species 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 210000000172 cytosol Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N glycerol 1-phosphate Chemical compound OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 239000012074 organic phase Substances 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161467249P | 2011-03-24 | 2011-03-24 | |
| US201161467261P | 2011-03-24 | 2011-03-24 | |
| US201161467271P | 2011-03-24 | 2011-03-24 | |
| US61/467,261 | 2011-03-24 | ||
| US61/467,271 | 2011-03-24 | ||
| US61/467,249 | 2011-03-24 | ||
| US201161472497P | 2011-04-06 | 2011-04-06 | |
| US201161472484P | 2011-04-06 | 2011-04-06 | |
| US201161472474P | 2011-04-06 | 2011-04-06 | |
| US201161472487P | 2011-04-06 | 2011-04-06 | |
| US61/472,474 | 2011-04-06 | ||
| US61/472,487 | 2011-04-06 | ||
| US61/472,497 | 2011-04-06 | ||
| US61/472,484 | 2011-04-06 | ||
| US201161570513P | 2011-12-14 | 2011-12-14 | |
| US61/570,513 | 2011-12-14 | ||
| PCT/US2012/030479 WO2012129555A2 (en) | 2011-03-24 | 2012-03-23 | Host cells and methods for production of isobutanol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508541A JP2014508541A (ja) | 2014-04-10 |
| JP2014508541A5 true JP2014508541A5 (enExample) | 2015-05-07 |
| JP6099623B2 JP6099623B2 (ja) | 2017-03-22 |
Family
ID=46880082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501294A Active JP6099623B2 (ja) | 2011-03-24 | 2012-03-23 | イソブタノール生成のための宿主細胞及び方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9790521B2 (enExample) |
| EP (1) | EP2689014B1 (enExample) |
| JP (1) | JP6099623B2 (enExample) |
| KR (1) | KR20140092759A (enExample) |
| CN (1) | CN103827304B (enExample) |
| AR (1) | AR088778A1 (enExample) |
| AU (2) | AU2012230737B2 (enExample) |
| BR (1) | BR112013024328A2 (enExample) |
| CA (1) | CA2831130C (enExample) |
| HU (1) | HUE045191T2 (enExample) |
| MX (1) | MX347976B (enExample) |
| WO (1) | WO2012129555A2 (enExample) |
| ZA (1) | ZA201306708B (enExample) |
Families Citing this family (51)
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| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| NZ579780A (en) | 2007-04-18 | 2012-07-27 | Butamax Advanced Biofuels Llc | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| CN102186983A (zh) | 2008-09-29 | 2011-09-14 | 布特马斯先进生物燃料有限责任公司 | 酵母中提高的异源Fe-S酶活性 |
| MX2012007583A (es) | 2009-12-29 | 2012-07-30 | Butamax Tm Advanced Biofuels | Alcohol deshidrogenasas (adh) utiles para la produccion fermentativa de alcoholes alquilicos de cadena corta. |
| WO2011142865A2 (en) | 2010-02-12 | 2011-11-17 | Gevo, Inc. | Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals, and amino acids |
| CN102782119B (zh) | 2010-02-17 | 2016-03-16 | 布特马斯先进生物燃料有限责任公司 | 改善需Fe-S簇蛋白质的活性 |
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| WO2014151645A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Process for maximizing biomass growth and butanol yield by feedback control |
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| US9580705B2 (en) | 2013-03-15 | 2017-02-28 | Butamax Advanced Biofuels Llc | DHAD variants and methods of screening |
| CN105073991B (zh) * | 2013-03-28 | 2019-04-05 | 株式会社钟化 | 改变型羰基还原酶及其基因 |
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| US20160376600A1 (en) | 2013-11-25 | 2016-12-29 | Genomatica, Inc. | Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol |
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| KR101632642B1 (ko) | 2015-01-29 | 2016-06-22 | 씨제이제일제당 주식회사 | 신규한 프로모터 및 그의 용도 |
| CN110177801B (zh) * | 2016-11-09 | 2024-02-23 | 丹尼斯科美国公司 | 具有改善的醇生产的酵母 |
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| CN111826405B (zh) * | 2019-04-16 | 2022-09-27 | 中国科学院大连化学物理研究所 | 一种生物催化还原丙酮酸产d-乳酸的方法 |
| CN110982771B (zh) * | 2019-12-26 | 2021-05-28 | 江南大学 | 一种合成对羟基扁桃酸的方法 |
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| US9580705B2 (en) | 2013-03-15 | 2017-02-28 | Butamax Advanced Biofuels Llc | DHAD variants and methods of screening |
-
2012
- 2012-03-23 EP EP12760879.2A patent/EP2689014B1/en active Active
- 2012-03-23 JP JP2014501294A patent/JP6099623B2/ja active Active
- 2012-03-23 US US13/428,585 patent/US9790521B2/en active Active
- 2012-03-23 CN CN201280024903.2A patent/CN103827304B/zh not_active Expired - Fee Related
- 2012-03-23 WO PCT/US2012/030479 patent/WO2012129555A2/en not_active Ceased
- 2012-03-23 MX MX2013010823A patent/MX347976B/es active IP Right Grant
- 2012-03-23 BR BR112013024328-7A patent/BR112013024328A2/pt not_active Application Discontinuation
- 2012-03-23 CA CA2831130A patent/CA2831130C/en active Active
- 2012-03-23 HU HUE12760879A patent/HUE045191T2/hu unknown
- 2012-03-23 KR KR1020137027906A patent/KR20140092759A/ko not_active Ceased
- 2012-03-23 AU AU2012230737A patent/AU2012230737B2/en active Active
- 2012-03-26 AR ARP120101001A patent/AR088778A1/es unknown
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2013
- 2013-03-15 US US13/840,676 patent/US9422582B2/en active Active
- 2013-03-15 US US13/840,649 patent/US9422581B2/en active Active
- 2013-09-06 ZA ZA2013/06708A patent/ZA201306708B/en unknown
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- 2017-01-20 AU AU2017200439A patent/AU2017200439A1/en not_active Abandoned
- 2017-04-03 US US15/477,980 patent/US20170275652A1/en not_active Abandoned
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