JP2014506478A5 - - Google Patents
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- Publication number
- JP2014506478A5 JP2014506478A5 JP2013555385A JP2013555385A JP2014506478A5 JP 2014506478 A5 JP2014506478 A5 JP 2014506478A5 JP 2013555385 A JP2013555385 A JP 2013555385A JP 2013555385 A JP2013555385 A JP 2013555385A JP 2014506478 A5 JP2014506478 A5 JP 2014506478A5
- Authority
- JP
- Japan
- Prior art keywords
- acetone
- microorganism
- isopropanol
- coa
- transferase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 42
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 30
- 244000005700 microbiome Species 0.000 claims 27
- 102000004190 Enzymes Human genes 0.000 claims 10
- 108090000790 Enzymes Proteins 0.000 claims 10
- 102000004357 Transferases Human genes 0.000 claims 8
- 108090000992 Transferases Proteins 0.000 claims 8
- 239000000758 substrate Substances 0.000 claims 8
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 7
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 7
- 239000002243 precursor Substances 0.000 claims 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- 241000193403 Clostridium Species 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 4
- 108090000489 Carboxy-Lyases Proteins 0.000 claims 4
- OJFDKHTZOUZBOS-CITAKDKDSA-N acetoacetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OJFDKHTZOUZBOS-CITAKDKDSA-N 0.000 claims 4
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 4
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 claims 4
- 239000005516 coenzyme A Substances 0.000 claims 4
- 229940093530 coenzyme a Drugs 0.000 claims 4
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 claims 3
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 2
- 101150078509 ADH2 gene Proteins 0.000 claims 2
- 101150026777 ADH5 gene Proteins 0.000 claims 2
- 101100269269 Drosophila mayaguana Adh gene Proteins 0.000 claims 2
- 101100054943 Mus musculus Adh4 gene Proteins 0.000 claims 2
- 102000002932 Thiolase Human genes 0.000 claims 2
- 108060008225 Thiolase Proteins 0.000 claims 2
- 101150067366 adh gene Proteins 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- WTLNOANVTIKPEE-UHFFFAOYSA-N 2-acetyloxypropanoic acid Chemical compound OC(=O)C(C)OC(C)=O WTLNOANVTIKPEE-UHFFFAOYSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 244000298715 Actinidia chinensis Species 0.000 claims 1
- 235000009434 Actinidia chinensis Nutrition 0.000 claims 1
- 235000009436 Actinidia deliciosa Nutrition 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 101100385572 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) ctfA gene Proteins 0.000 claims 1
- 101100385573 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) ctfB gene Proteins 0.000 claims 1
- 241001656809 Clostridium autoethanogenum Species 0.000 claims 1
- 241000186394 Eubacterium Species 0.000 claims 1
- 241000194035 Lactococcus lactis Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000178986 Oxobacter Species 0.000 claims 1
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 1
- 241000186339 Thermoanaerobacter Species 0.000 claims 1
- 108091022873 acetoacetate decarboxylase Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 101150096860 thlA gene Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161446832P | 2011-02-25 | 2011-02-25 | |
| US61/446,832 | 2011-02-25 | ||
| PCT/NZ2012/000022 WO2012115527A2 (en) | 2011-02-25 | 2012-02-24 | Recombinant microorganisms and uses therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506478A JP2014506478A (ja) | 2014-03-17 |
| JP2014506478A5 true JP2014506478A5 (enExample) | 2015-04-16 |
| JP6199747B2 JP6199747B2 (ja) | 2017-09-20 |
Family
ID=46721376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013555385A Active JP6199747B2 (ja) | 2011-02-25 | 2012-02-24 | 組換え微生物およびそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP2678432B1 (enExample) |
| JP (1) | JP6199747B2 (enExample) |
| KR (2) | KR102121886B1 (enExample) |
| CN (2) | CN108486169B (enExample) |
| AU (1) | AU2012221176B2 (enExample) |
| BR (1) | BR112013021524A2 (enExample) |
| CA (2) | CA2995872C (enExample) |
| DK (1) | DK2678432T3 (enExample) |
| ES (1) | ES2702621T3 (enExample) |
| MY (2) | MY168208A (enExample) |
| PL (1) | PL2678432T4 (enExample) |
| TW (1) | TWI541348B (enExample) |
| WO (1) | WO2012115527A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104619834B (zh) | 2012-04-05 | 2018-06-15 | 朗泽科技新西兰有限公司 | 改变代谢活性的酶 |
| US20130316364A1 (en) | 2012-05-23 | 2013-11-28 | Lanzatech New Zealand Limited | Selection Method and Recombinant Microorganisms and uses Therefor |
| IN2014DN10168A (enExample) | 2012-05-30 | 2015-08-21 | Lanzatech New Zealand Ltd | |
| US20130323820A1 (en) | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| CN104919037A (zh) | 2012-06-08 | 2015-09-16 | 朗泽科技新西兰有限公司 | 重组微生物和其用途 |
| US9347076B2 (en) | 2012-06-21 | 2016-05-24 | Lanzatech New Zealand Limited | Recombinant microorganisms that make biodiesel |
| WO2014197746A1 (en) * | 2013-06-05 | 2014-12-11 | Lanzatech New Zealand Limited | Recombinant microorganisms exhibiting increased flux through a fermentation pathway |
| DK3047028T5 (da) * | 2013-09-22 | 2024-10-14 | Lanzatech Nz Inc | Fermenteringsfremgangsmåde |
| US20150152445A1 (en) * | 2013-12-03 | 2015-06-04 | Lanzatech New Zealand Limited | Microorganisms and methods for the production of ketones |
| EP3099779B1 (en) | 2014-01-28 | 2020-09-02 | LanzaTech New Zealand Limited | Method of producing a recombinant microorganism |
| TWI689592B (zh) | 2014-10-22 | 2020-04-01 | 紐西蘭商藍瑟科技紐西蘭有限公司 | 多段生物反應器方法 |
| WO2016065085A1 (en) | 2014-10-22 | 2016-04-28 | Lanzatech New Zealand Limited | Gas testing unit and method |
| AU2015360786B2 (en) | 2014-12-08 | 2021-10-21 | Lanzatech Nz, Inc. | Recombinant microorganisms exhibiting increased flux through a fermentation pathway |
| WO2016138050A1 (en) | 2015-02-23 | 2016-09-01 | Lanzatech New Zealand Limited | Recombinant acetogenic bacterium for the conversion of methane to products |
| JP6905518B2 (ja) | 2015-10-13 | 2021-07-21 | ランザテク・ニュージーランド・リミテッド | エネルギー発生発酵経路を含む遺伝子操作細菌 |
| CA3010412C (en) | 2015-12-03 | 2020-04-14 | Lanzatech New Zealand Limited | Arginine supplementation to improve efficiency in gas fermenting acetogens |
| US10358661B2 (en) | 2015-12-28 | 2019-07-23 | Lanzatech New Zealand Limited | Microorganism with modified hydrogenase activity |
| US10358662B2 (en) | 2016-02-01 | 2019-07-23 | Lanzatech New Zealand Limited | Integrated fermentation and electrolysis process |
| SG11201807025SA (en) | 2016-02-26 | 2018-09-27 | Lanzatech New Zealand Ltd | Crispr/cas systems for c-1 fixing bacteria |
| KR20230044031A (ko) | 2016-05-14 | 2023-03-31 | 란자테크, 인크. | 알데히드:페레독신 옥시도리덕타제 활성이 변경된 미생물 및 관련 방법 |
| CN117551705A (zh) | 2017-09-08 | 2024-02-13 | 朗泽科技有限公司 | 用于使用富氢气的含有c1的底物生产代谢物的方法和系统 |
| CA3090411A1 (en) | 2018-02-12 | 2019-08-15 | Lanzatech, Inc. | A process for improving carbon conversion efficiency |
| MY204224A (en) | 2018-04-20 | 2024-08-16 | Lanzatech Inc | Intermittent electrolysis streams |
| CA3120151C (en) | 2018-11-19 | 2024-04-30 | Lanzatech, Inc. | Integration of fermentation and gasification |
| US11091415B2 (en) | 2019-02-08 | 2021-08-17 | Lanzatech, Inc. | Process for recovering close boiling products |
| CN113614240B (zh) | 2019-03-20 | 2024-12-13 | 环球生物能源公司 | 用于从乙酰-CoA生产异丁烯的改进手段和方法 |
| KR20240158377A (ko) | 2019-07-11 | 2024-11-04 | 란자테크, 인크. | 가스 이용률을 최적화하는 방법 |
| CN111057686B (zh) * | 2019-12-23 | 2021-05-04 | 浙江大学 | 一种醇脱氢酶突变体及应用 |
| US11932818B2 (en) | 2020-03-16 | 2024-03-19 | Lanzatech, Inc. | Tail gas of gas fermentation to dry gasification feedstock |
| AU2021237368B2 (en) | 2020-03-18 | 2025-05-08 | Lanzatech, Inc. | Fermentative production of 2-phenylethanol from gaseous substrates |
| JP2023520257A (ja) * | 2020-06-06 | 2023-05-16 | ランザテク，インコーポレイテッド | アセトラクテートデカルボキシラーゼ遺伝子座位でのノックインを有する微生物 |
| TW202212566A (zh) * | 2020-09-25 | 2022-04-01 | 美商朗澤科技有限公司 | 重組微生物及其用途 |
| AU2022218205A1 (en) | 2021-02-08 | 2023-05-25 | Lanzatech, Inc. | Recombinant microorganisms and uses therefor |
| WO2022217284A1 (en) | 2021-04-09 | 2022-10-13 | Lanzatech, Inc. | Flexible fermentation platform for improved conversion of carbon dioxide into products |
| WO2022217282A1 (en) | 2021-04-09 | 2022-10-13 | Lanzatech, Inc. | Process and apparatus for providing a feedstock |
| CN114561416B (zh) * | 2022-04-27 | 2022-07-15 | 深圳中科翎碳生物科技有限公司 | 利用电能固定co2及合成异丙醇的工程菌及构建方法 |
| WO2024036187A1 (en) | 2022-08-10 | 2024-02-15 | Lanzatech, Inc. | Carbon sequestration in soils with production of chemical products |
| CN121464221A (zh) | 2023-05-11 | 2026-02-03 | 赢创运营有限公司 | 丙酮的生物技术生产 |
| CN117625571B (zh) * | 2023-12-05 | 2025-06-10 | 迪嘉药业集团股份有限公司 | 一种改进的酮还原酶及其在依折麦布制备中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
| UA72220C2 (uk) | 1998-09-08 | 2005-02-15 | Байоенджініерінг Рісорсиз, Інк. | Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання |
| JP4883872B2 (ja) | 2000-07-25 | 2012-02-22 | エモース・フアンデーシヨン・インコーポレーテツド | 微生物発酵によるエタノール生産を向上させる方法 |
| EP1948814B1 (en) * | 2005-10-26 | 2018-11-21 | Butamax (TM) Advanced Biofuels LLC | Fermentive production of four carbon alcohols |
| NZ546496A (en) * | 2006-04-07 | 2008-09-26 | Lanzatech New Zealand Ltd | Gas treatment process |
| US7704723B2 (en) | 2006-08-31 | 2010-04-27 | The Board Of Regents For Oklahoma State University | Isolation and characterization of novel clostridial species |
| JP2011500031A (ja) * | 2007-10-12 | 2011-01-06 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | イソプロパノールを生産するように操作された微生物 |
| KR101375029B1 (ko) * | 2007-11-13 | 2014-03-14 | 란자테크 뉴질랜드 리미티드 | 신규 세균 및 이의 이용 방법 |
| US8119378B2 (en) * | 2008-03-12 | 2012-02-21 | Lanzatech New Zealand Limited | Microbial alcohol production process |
| EP2270135A4 (en) | 2008-04-25 | 2013-04-10 | Res Inst Innovative Tech Earth | GENETICALLY MODIFIED CORYNEFORME BACTERIA FOR THE MANUFACTURE OF ISOPROPANOL |
| KR20110097951A (ko) * | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| DE102009002583A1 (de) * | 2009-04-23 | 2010-10-28 | Evonik Degussa Gmbh | Zellen und Verfahren zur Herstellung von Aceton |
| CN102666862A (zh) * | 2009-08-21 | 2012-09-12 | 马斯科马公司 | 在联合生物加工生物体中生产丙醇、醇和多元醇 |
| US8143037B2 (en) | 2010-03-19 | 2012-03-27 | Coskata, Inc. | Ethanologenic Clostridium species, Clostridium coskatii |
-
2012
- 2012-02-24 WO PCT/NZ2012/000022 patent/WO2012115527A2/en not_active Ceased
- 2012-02-24 CA CA2995872A patent/CA2995872C/en active Active
- 2012-02-24 EP EP12749472.2A patent/EP2678432B1/en active Active
- 2012-02-24 KR KR1020197023252A patent/KR102121886B1/ko active Active
- 2012-02-24 KR KR1020137025077A patent/KR102015672B1/ko active Active
- 2012-02-24 BR BR112013021524A patent/BR112013021524A2/pt not_active Application Discontinuation
- 2012-02-24 MY MYPI2013701492A patent/MY168208A/en unknown
- 2012-02-24 CN CN201810393540.9A patent/CN108486169B/zh active Active
- 2012-02-24 EP EP18179128.6A patent/EP3401405A1/en active Pending
- 2012-02-24 ES ES12749472T patent/ES2702621T3/es active Active
- 2012-02-24 DK DK12749472.2T patent/DK2678432T3/en active
- 2012-02-24 JP JP2013555385A patent/JP6199747B2/ja active Active
- 2012-02-24 CN CN201280020456.3A patent/CN103502435B/zh active Active
- 2012-02-24 MY MYPI2018700680A patent/MY193665A/en unknown
- 2012-02-24 AU AU2012221176A patent/AU2012221176B2/en active Active
- 2012-02-24 PL PL12749472T patent/PL2678432T4/pl unknown
- 2012-02-24 CA CA2825267A patent/CA2825267C/en active Active
- 2012-02-24 TW TW101106425A patent/TWI541348B/zh active
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