JP6199747B2 - 組換え微生物およびそれらの使用 - Google Patents

組換え微生物およびそれらの使用 Download PDF

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Publication number
JP6199747B2
JP6199747B2 JP2013555385A JP2013555385A JP6199747B2 JP 6199747 B2 JP6199747 B2 JP 6199747B2 JP 2013555385 A JP2013555385 A JP 2013555385A JP 2013555385 A JP2013555385 A JP 2013555385A JP 6199747 B2 JP6199747 B2 JP 6199747B2
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microorganism
seq
acetone
isopropanol
nucleic acid
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JP2014506478A (ja
JP2014506478A5 (enExample
Inventor
シンプソン，ショーン・デニス
ケプケ，ミハエル
リュウ，ファンミン
チェン，ウェンディ・イーティーン
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ランザテク・ニュージーランド・リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/28—Acetone-containing products
    • C12P7/30—Acetone-containing products produced from substrate containing inorganic compounds other than water
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01004—Acetoacetate decarboxylase (4.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01074—Indolepyruvate decarboxylase (4.1.1.74)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/10—Process efficiency
    • Y02P20/133—Renewable energy sources, e.g. sunlight

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2013555385A 2011-02-25 2012-02-24 組換え微生物およびそれらの使用 Active JP6199747B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161446832P 2011-02-25 2011-02-25
US61/446,832 2011-02-25
PCT/NZ2012/000022 WO2012115527A2 (en) 2011-02-25 2012-02-24 Recombinant microorganisms and uses therefor

Publications (3)

Publication Number Publication Date
JP2014506478A JP2014506478A (ja) 2014-03-17
JP2014506478A5 JP2014506478A5 (enExample) 2015-04-16
JP6199747B2 true JP6199747B2 (ja) 2017-09-20

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JP2013555385A Active JP6199747B2 (ja) 2011-02-25 2012-02-24 組換え微生物およびそれらの使用

Country Status (13)

Country Link
EP (2) EP2678432B1 (enExample)
JP (1) JP6199747B2 (enExample)
KR (2) KR102121886B1 (enExample)
CN (2) CN108486169B (enExample)
AU (1) AU2012221176B2 (enExample)
BR (1) BR112013021524A2 (enExample)
CA (2) CA2995872C (enExample)
DK (1) DK2678432T3 (enExample)
ES (1) ES2702621T3 (enExample)
MY (2) MY168208A (enExample)
PL (1) PL2678432T4 (enExample)
TW (1) TWI541348B (enExample)
WO (1) WO2012115527A2 (enExample)

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CN104619834B (zh) 2012-04-05 2018-06-15 朗泽科技新西兰有限公司 改变代谢活性的酶
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US20130323820A1 (en) 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
CN104919037A (zh) 2012-06-08 2015-09-16 朗泽科技新西兰有限公司 重组微生物和其用途
US9347076B2 (en) 2012-06-21 2016-05-24 Lanzatech New Zealand Limited Recombinant microorganisms that make biodiesel
WO2014197746A1 (en) * 2013-06-05 2014-12-11 Lanzatech New Zealand Limited Recombinant microorganisms exhibiting increased flux through a fermentation pathway
DK3047028T5 (da) * 2013-09-22 2024-10-14 Lanzatech Nz Inc Fermenteringsfremgangsmåde
US20150152445A1 (en) * 2013-12-03 2015-06-04 Lanzatech New Zealand Limited Microorganisms and methods for the production of ketones
EP3099779B1 (en) 2014-01-28 2020-09-02 LanzaTech New Zealand Limited Method of producing a recombinant microorganism
TWI689592B (zh) 2014-10-22 2020-04-01 紐西蘭商藍瑟科技紐西蘭有限公司 多段生物反應器方法
WO2016065085A1 (en) 2014-10-22 2016-04-28 Lanzatech New Zealand Limited Gas testing unit and method
AU2015360786B2 (en) 2014-12-08 2021-10-21 Lanzatech Nz, Inc. Recombinant microorganisms exhibiting increased flux through a fermentation pathway
WO2016138050A1 (en) 2015-02-23 2016-09-01 Lanzatech New Zealand Limited Recombinant acetogenic bacterium for the conversion of methane to products
JP6905518B2 (ja) 2015-10-13 2021-07-21 ランザテク・ニュージーランド・リミテッド エネルギー発生発酵経路を含む遺伝子操作細菌
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KR20240158377A (ko) 2019-07-11 2024-11-04 란자테크, 인크. 가스 이용률을 최적화하는 방법
CN111057686B (zh) * 2019-12-23 2021-05-04 浙江大学 一种醇脱氢酶突变体及应用
US11932818B2 (en) 2020-03-16 2024-03-19 Lanzatech, Inc. Tail gas of gas fermentation to dry gasification feedstock
AU2021237368B2 (en) 2020-03-18 2025-05-08 Lanzatech, Inc. Fermentative production of 2-phenylethanol from gaseous substrates
JP2023520257A (ja) * 2020-06-06 2023-05-16 ランザテク，インコーポレイテッド アセトラクテートデカルボキシラーゼ遺伝子座位でのノックインを有する微生物
TW202212566A (zh) * 2020-09-25 2022-04-01 美商朗澤科技有限公司 重組微生物及其用途
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CN114561416B (zh) * 2022-04-27 2022-07-15 深圳中科翎碳生物科技有限公司 利用电能固定co2及合成异丙醇的工程菌及构建方法
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Publication number Publication date
PL2678432T3 (pl) 2019-05-31
JP2014506478A (ja) 2014-03-17
PL2678432T4 (pl) 2019-05-31
MY193665A (en) 2022-10-24
KR102015672B1 (ko) 2019-08-29
KR20140012106A (ko) 2014-01-29
CA2995872A1 (en) 2012-08-30
EP2678432B1 (en) 2018-08-01
ES2702621T3 (es) 2019-03-04
CN108486169A (zh) 2018-09-04
MY168208A (en) 2018-10-15
EP2678432A2 (en) 2014-01-01
WO2012115527A3 (en) 2013-01-10
CA2825267C (en) 2018-04-03
TW201309795A (zh) 2013-03-01
CA2995872C (en) 2019-09-17
KR20190097292A (ko) 2019-08-20
EP2678432A4 (en) 2016-06-22
CN108486169B (zh) 2022-08-12
NZ614459A (en) 2015-09-25
CN103502435A (zh) 2014-01-08
KR102121886B1 (ko) 2020-06-15
AU2012221176A1 (en) 2013-05-09
DK2678432T3 (en) 2018-11-26
EP3401405A1 (en) 2018-11-14
WO2012115527A2 (en) 2012-08-30
AU2012221176B2 (en) 2015-03-19
BR112013021524A2 (pt) 2017-06-13
CN103502435B (zh) 2018-05-18
CA2825267A1 (en) 2012-08-30
TWI541348B (zh) 2016-07-11

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