JP6199747B2 - 組換え微生物およびそれらの使用 - Google Patents

組換え微生物およびそれらの使用 Download PDF

Info

Publication number
JP6199747B2
JP6199747B2 JP2013555385A JP2013555385A JP6199747B2 JP 6199747 B2 JP6199747 B2 JP 6199747B2 JP 2013555385 A JP2013555385 A JP 2013555385A JP 2013555385 A JP2013555385 A JP 2013555385A JP 6199747 B2 JP6199747 B2 JP 6199747B2
Authority
JP
Japan
Prior art keywords
microorganism
seq
acetone
isopropanol
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013555385A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014506478A5 (enExample
JP2014506478A (ja
Inventor
シンプソン，ショーン・デニス
ケプケ，ミハエル
リュウ，ファンミン
チェン，ウェンディ・イーティーン
Original Assignee
ランザテク・ニュージーランド・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ランザテク・ニュージーランド・リミテッド filed Critical ランザテク・ニュージーランド・リミテッド
Publication of JP2014506478A publication Critical patent/JP2014506478A/ja
Publication of JP2014506478A5 publication Critical patent/JP2014506478A5/ja
Application granted granted Critical
Publication of JP6199747B2 publication Critical patent/JP6199747B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/28—Acetone-containing products
    • C12P7/30—Acetone-containing products produced from substrate containing inorganic compounds other than water
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01004—Acetoacetate decarboxylase (4.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01074—Indolepyruvate decarboxylase (4.1.1.74)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/10—Process efficiency
    • Y02P20/133—Renewable energy sources, e.g. sunlight

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2013555385A 2011-02-25 2012-02-24 組換え微生物およびそれらの使用 Active JP6199747B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161446832P 2011-02-25 2011-02-25
US61/446,832 2011-02-25
PCT/NZ2012/000022 WO2012115527A2 (en) 2011-02-25 2012-02-24 Recombinant microorganisms and uses therefor

Publications (3)

Publication Number Publication Date
JP2014506478A JP2014506478A (ja) 2014-03-17
JP2014506478A5 JP2014506478A5 (enExample) 2015-04-16
JP6199747B2 true JP6199747B2 (ja) 2017-09-20

Family

ID=46721376

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013555385A Active JP6199747B2 (ja) 2011-02-25 2012-02-24 組換え微生物およびそれらの使用

Country Status (13)

Country Link
EP (2) EP3401405A1 (enExample)
JP (1) JP6199747B2 (enExample)
KR (2) KR102121886B1 (enExample)
CN (2) CN108486169B (enExample)
AU (1) AU2012221176B2 (enExample)
BR (1) BR112013021524A2 (enExample)
CA (2) CA2995872C (enExample)
DK (1) DK2678432T3 (enExample)
ES (1) ES2702621T3 (enExample)
MY (2) MY168208A (enExample)
PL (1) PL2678432T3 (enExample)
TW (1) TWI541348B (enExample)
WO (1) WO2012115527A2 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2834351B1 (en) * 2012-04-05 2019-03-27 LanzaTech New Zealand Limited Enzyme-altered metabolite activity
US20130316364A1 (en) 2012-05-23 2013-11-28 Lanzatech New Zealand Limited Selection Method and Recombinant Microorganisms and uses Therefor
CN104508136A (zh) 2012-05-30 2015-04-08 新西兰郎泽科技公司 重组微生物及其用途
US20130323820A1 (en) 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
JP6381525B2 (ja) 2012-06-08 2018-08-29 ランザテク・ニュージーランド・リミテッド 組換え微生物およびその使用
US9347076B2 (en) 2012-06-21 2016-05-24 Lanzatech New Zealand Limited Recombinant microorganisms that make biodiesel
KR20160018568A (ko) * 2013-06-05 2016-02-17 란자테크 뉴질랜드 리미티드 발효 경로를 통한 플럭스의 증가를 나타내는 재조합 미생물
PT3047028T (pt) * 2013-09-22 2023-02-02 Lanzatech Nz Inc Processo de fermentação
WO2015085015A1 (en) * 2013-12-03 2015-06-11 Lanzatech New Zealand Limited Microorganisms and methods for the production of ketones
SG11201605775UA (en) 2014-01-28 2016-08-30 Lanzatech New Zealand Ltd Method of producing a recombinant microorganism
US9834792B2 (en) 2014-10-22 2017-12-05 Lanzatech New Zealand Limited Multi-stage bioreactor processes
EP3210012B1 (en) 2014-10-22 2023-06-07 LanzaTech NZ, Inc. Gas testing unit and method
WO2016094334A1 (en) 2014-12-08 2016-06-16 Lanzatech New Zealand Limited Recombinant microorganisms exhibiting increased flux through a fermentation pathway
WO2016138050A1 (en) 2015-02-23 2016-09-01 Lanzatech New Zealand Limited Recombinant acetogenic bacterium for the conversion of methane to products
MX2023003058A (es) 2015-10-13 2023-04-05 Lanzatech Nz Inc Bacteria diseñada por ingeniería genética que comprende una trayectoria de fermentación que genera energía.
DK3384005T3 (da) 2015-12-03 2022-04-11 Lanzatech Nz Inc Arginin som eneste nitrogenkilde til C1-fikserende mikroorganisme
US10358661B2 (en) 2015-12-28 2019-07-23 Lanzatech New Zealand Limited Microorganism with modified hydrogenase activity
WO2017136478A1 (en) 2016-02-01 2017-08-10 Lanzatech New Zealand Limited Integrated fermentation and electrolysis process
CA3015665C (en) 2016-02-26 2020-09-22 Lanzatech New Zealand Limited Crispr/cas systems for c1-fixing bacteria
SG11201810031RA (en) 2016-05-14 2018-12-28 Lanzatech Inc Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods
EP3679149B1 (en) 2017-09-08 2022-06-29 Lanzatech, Inc. Processes for metabolite production using hydrogen rich c1-containing substrates
US11359294B2 (en) 2018-02-12 2022-06-14 Lanzatech, Inc. Process for improving carbon conversion efficiency
MY204224A (en) 2018-04-20 2024-08-16 Lanzatech Inc Intermittent electrolysis streams
MY199603A (en) 2018-11-19 2023-11-08 Lanzatech Inc Integration of fermentation and gasification
US11091415B2 (en) 2019-02-08 2021-08-17 Lanzatech, Inc. Process for recovering close boiling products
WO2020188033A1 (en) 2019-03-20 2020-09-24 Global Bioenergies Improved means and methods for producing isobutene from acetyl-coa
CN112955560A (zh) 2019-07-11 2021-06-11 朗泽科技有限公司 优化气体利用的方法
CN111057686B (zh) * 2019-12-23 2021-05-04 浙江大学 一种醇脱氢酶突变体及应用
US11932818B2 (en) 2020-03-16 2024-03-19 Lanzatech, Inc. Tail gas of gas fermentation to dry gasification feedstock
CA3171681A1 (en) 2020-03-18 2021-09-23 Fungmin Liew Fermentative production of 2-phenylethanol from gaseous substrates
BR112022024652B1 (pt) * 2020-06-06 2024-01-16 Lanzatech, Inc Micro-organismo geneticamente modificado, e, método para a produção de um produto
US20220098560A1 (en) * 2020-09-25 2022-03-31 Lanzatech, Inc. Recombinant microorganisms and uses therefor
WO2022170191A1 (en) 2021-02-08 2022-08-11 Lanzatech, Inc. Recombinant microorganisms and uses therefor
BR112023020761A2 (pt) 2021-04-09 2023-12-12 Lanzatech Inc Processo para fornecer uma matéria-prima, e, aparelho para fornecer uma matéria-prima de fermentação gasosa
CN114561416B (zh) * 2022-04-27 2022-07-15 深圳中科翎碳生物科技有限公司 利用电能固定co2及合成异丙醇的工程菌及构建方法
US12129503B2 (en) 2022-08-10 2024-10-29 Lanzatech, Inc. Carbon sequestration in soils with production of chemical products
KR20260010725A (ko) 2023-05-11 2026-01-21 에보니크 오퍼레이션즈 게엠베하 아세톤의 생명공학적 생산
CN117625571B (zh) * 2023-12-05 2025-06-10 迪嘉药业集团股份有限公司 一种改进的酮还原酶及其在依折麦布制备中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
UA72220C2 (uk) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання
ATE332390T1 (de) 2000-07-25 2006-07-15 Emmaus Foundation Inc Verfahren zur produktionssteigerung von die fermentativen erzeugnung von ethanol
EP3301182B1 (en) * 2005-10-26 2020-03-18 Butamax (TM) Advanced Biofuels LLC Fermentative production of four carbon alcohols
NZ546496A (en) * 2006-04-07 2008-09-26 Lanzatech New Zealand Ltd Gas treatment process
US7704723B2 (en) 2006-08-31 2010-04-27 The Board Of Regents For Oklahoma State University Isolation and characterization of novel clostridial species
CN101903530A (zh) * 2007-10-12 2010-12-01 加利福尼亚大学董事会 被改造以产生异丙醇的微生物
EA022710B1 (ru) * 2007-11-13 2016-02-29 Ланзатек Нью Зиленд Лимитед Штамм бактерии clostridium autoethanogenum, способный продуцировать этанол и ацетат путем анаэробной ферментации субстрата, содержащего co
BRPI0909334B1 (pt) * 2008-03-12 2019-10-29 Lanzatech New Zealand Ltd método para a conversão de ácido em álcool correspondente
WO2009131040A1 (ja) * 2008-04-25 2009-10-29 財団法人地球環境産業技術研究機構 イソプロパノール生産能を有するコリネ型細菌の形質転換体
CA2746952A1 (en) * 2008-12-16 2010-06-24 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
DE102009002583A1 (de) * 2009-04-23 2010-10-28 Evonik Degussa Gmbh Zellen und Verfahren zur Herstellung von Aceton
EP2467490A1 (en) * 2009-08-21 2012-06-27 Mascoma Corporation Production of propanols, alcohols, and polyols in consolidated bioprocessing organisms
US8143037B2 (en) 2010-03-19 2012-03-27 Coskata, Inc. Ethanologenic Clostridium species, Clostridium coskatii

Also Published As

Publication number Publication date
KR102015672B1 (ko) 2019-08-29
CN103502435B (zh) 2018-05-18
AU2012221176A1 (en) 2013-05-09
CA2825267A1 (en) 2012-08-30
TWI541348B (zh) 2016-07-11
CN108486169A (zh) 2018-09-04
EP2678432A2 (en) 2014-01-01
MY168208A (en) 2018-10-15
CN108486169B (zh) 2022-08-12
DK2678432T3 (en) 2018-11-26
NZ614459A (en) 2015-09-25
EP2678432B1 (en) 2018-08-01
CA2995872A1 (en) 2012-08-30
JP2014506478A (ja) 2014-03-17
MY193665A (en) 2022-10-24
CA2825267C (en) 2018-04-03
CA2995872C (en) 2019-09-17
PL2678432T4 (pl) 2019-05-31
CN103502435A (zh) 2014-01-08
WO2012115527A2 (en) 2012-08-30
TW201309795A (zh) 2013-03-01
BR112013021524A2 (pt) 2017-06-13
KR20140012106A (ko) 2014-01-29
EP2678432A4 (en) 2016-06-22
ES2702621T3 (es) 2019-03-04
AU2012221176B2 (en) 2015-03-19
KR20190097292A (ko) 2019-08-20
WO2012115527A3 (en) 2013-01-10
EP3401405A1 (en) 2018-11-14
PL2678432T3 (pl) 2019-05-31
KR102121886B1 (ko) 2020-06-15

Similar Documents

Publication Publication Date Title
AU2012221176B2 (en) Recombinant microorganisms and uses therefor
US9834795B2 (en) Recombinant microorganisms and uses therefor
US9365868B2 (en) Fermentation process for producing isopropanol using a recombinant microorganism
JP6445970B2 (ja) 組換え微生物およびその使用
AU2011318676B2 (en) Production of butanol from carbon monoxide by a recombinant microorganism
JP6381525B2 (ja) 組換え微生物およびその使用
CA2914003C (en) Recombinant microorganisms exhibiting increased flux through a fermentation pathway
JP2015505471A (ja) 組換え微生物およびその使用方法
NZ614459B2 (en) Recombinant microorganisms and uses therefor

Legal Events

Date Code Title Description
RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20141208

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20141210

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150224

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150224

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160329

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160629

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160815

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20161206

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170405

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20170412

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170530

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170712

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170822

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170824

R150 Certificate of patent or registration of utility model

Ref document number: 6199747

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250