JP2013539370A5 - - Google Patents
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- JP2013539370A5 JP2013539370A5 JP2013528269A JP2013528269A JP2013539370A5 JP 2013539370 A5 JP2013539370 A5 JP 2013539370A5 JP 2013528269 A JP2013528269 A JP 2013528269A JP 2013528269 A JP2013528269 A JP 2013528269A JP 2013539370 A5 JP2013539370 A5 JP 2013539370A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- recombinant host
- conversion
- product
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 35
- 238000006243 chemical reaction Methods 0.000 claims 21
- 108091033319 polynucleotide Proteins 0.000 claims 20
- 102000040430 polynucleotide Human genes 0.000 claims 20
- 239000002157 polynucleotide Substances 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 claims 14
- 239000000758 substrate Substances 0.000 claims 14
- WTLNOANVTIKPEE-UHFFFAOYSA-N 2-acetyloxypropanoic acid Chemical compound OC(=O)C(C)OC(C)=O WTLNOANVTIKPEE-UHFFFAOYSA-N 0.000 claims 12
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 11
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 11
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 claims 9
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 8
- ROWKJAVDOGWPAT-UHFFFAOYSA-N Acetoin Chemical compound CC(O)C(C)=O ROWKJAVDOGWPAT-UHFFFAOYSA-N 0.000 claims 8
- 210000000349 chromosome Anatomy 0.000 claims 7
- 238000000855 fermentation Methods 0.000 claims 7
- 230000004151 fermentation Effects 0.000 claims 7
- JTEYKUFKXGDTEU-UHFFFAOYSA-N 2,3-dihydroxy-3-methylbutanoic acid Chemical compound CC(C)(O)C(O)C(O)=O JTEYKUFKXGDTEU-UHFFFAOYSA-N 0.000 claims 6
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- KDSNLYIMUZNERS-UHFFFAOYSA-N 2-methylpropanamine Chemical compound CC(C)CN KDSNLYIMUZNERS-UHFFFAOYSA-N 0.000 claims 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 4
- 108010011939 Pyruvate Decarboxylase Proteins 0.000 claims 4
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- GFAZHVHNLUBROE-UHFFFAOYSA-N hydroxymethyl propionaldehyde Natural products CCC(=O)CO GFAZHVHNLUBROE-UHFFFAOYSA-N 0.000 claims 4
- 230000037361 pathway Effects 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 241000235648 Pichia Species 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 150000002192 fatty aldehydes Chemical class 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- FERWBXLFSBWTDE-UHFFFAOYSA-N 3-aminobutan-2-ol Chemical compound CC(N)C(C)O FERWBXLFSBWTDE-UHFFFAOYSA-N 0.000 claims 2
- RTDYVACWFWSTAJ-UHFFFAOYSA-N 3-aminobutan-2-yl dihydrogen phosphate Chemical compound CC(N)C(C)OP(O)(O)=O RTDYVACWFWSTAJ-UHFFFAOYSA-N 0.000 claims 2
- 108010000700 Acetolactate synthase Proteins 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 125000003158 alcohol group Chemical group 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000002191 fatty alcohols Chemical class 0.000 claims 2
- 230000004907 flux Effects 0.000 claims 2
- AEWHYWSPVRZHCT-NDZSKPAWSA-N isobutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(C)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 AEWHYWSPVRZHCT-NDZSKPAWSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000588986 Alcaligenes Species 0.000 claims 1
- 241000186063 Arthrobacter Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000186146 Brevibacterium Species 0.000 claims 1
- -1 C22 fatty acids Chemical class 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- 241000192700 Cyanobacteria Species 0.000 claims 1
- 241000194033 Enterococcus Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 101150096607 Fosl2 gene Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 102000000587 Glycerolphosphate Dehydrogenase Human genes 0.000 claims 1
- 108010041921 Glycerolphosphate Dehydrogenase Proteins 0.000 claims 1
- 108091029795 Intergenic region Proteins 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000235649 Kluyveromyces Species 0.000 claims 1
- 240000006024 Lactobacillus plantarum Species 0.000 claims 1
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 1
- 241000179039 Paenibacillus Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000316848 Rhodococcus <scale insect> Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000588901 Zymomonas Species 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000000172 cytosol Anatomy 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 150000002193 fatty amides Chemical class 0.000 claims 1
- 229940072205 lactobacillus plantarum Drugs 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000008016 vaporization Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38056310P | 2010-09-07 | 2010-09-07 | |
| US61/380,563 | 2010-09-07 | ||
| US201161466557P | 2011-03-23 | 2011-03-23 | |
| US61/466,557 | 2011-03-23 | ||
| PCT/US2011/050689 WO2012033832A2 (en) | 2010-09-07 | 2011-09-07 | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138178A Division JP6266707B2 (ja) | 2010-09-07 | 2016-07-13 | ピルベートからアセトラクテートへの変換を触媒するポリペプチドをコードするポリヌクレオチドの組込み |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013539370A JP2013539370A (ja) | 2013-10-24 |
| JP2013539370A5 true JP2013539370A5 (enExample) | 2014-10-16 |
| JP6008858B2 JP6008858B2 (ja) | 2016-10-19 |
Family
ID=45811143
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013528269A Active JP6008858B2 (ja) | 2010-09-07 | 2011-09-07 | ピルベートからアセトラクテートへの変換を触媒するポリペプチドをコードするポリヌクレオチドの組込み |
| JP2016138178A Expired - Fee Related JP6266707B2 (ja) | 2010-09-07 | 2016-07-13 | ピルベートからアセトラクテートへの変換を触媒するポリペプチドをコードするポリヌクレオチドの組込み |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138178A Expired - Fee Related JP6266707B2 (ja) | 2010-09-07 | 2016-07-13 | ピルベートからアセトラクテートへの変換を触媒するポリペプチドをコードするポリヌクレオチドの組込み |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US9267157B2 (enExample) |
| EP (2) | EP3269806B1 (enExample) |
| JP (2) | JP6008858B2 (enExample) |
| KR (1) | KR20130105649A (enExample) |
| CN (2) | CN105950525A (enExample) |
| AU (2) | AU2011299303B2 (enExample) |
| BR (1) | BR112013005386A2 (enExample) |
| CA (2) | CA2810244C (enExample) |
| MX (2) | MX346408B (enExample) |
| NZ (2) | NZ707800A (enExample) |
| WO (1) | WO2012033832A2 (enExample) |
| ZA (1) | ZA201301237B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9303225B2 (en) | 2005-10-26 | 2016-04-05 | Butamax Advanced Biofuels Llc | Method for the production of isobutanol by recombinant yeast |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| KR101573775B1 (ko) | 2007-04-18 | 2015-12-04 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산 |
| US8188250B2 (en) * | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| KR20110063576A (ko) | 2008-09-29 | 2011-06-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 효모에서 증가된 이종성 Ｆｅ-Ｓ 효소 활성 |
| WO2011041426A1 (en) * | 2009-09-29 | 2011-04-07 | Butamax(Tm) Advanced Biofuels Llc | Improved yeast production host cells |
| CN102762722B (zh) | 2009-12-29 | 2015-05-20 | 布特马斯先进生物燃料有限责任公司 | 用于发酵生产低级烷基醇的醇脱氢酶(adh) |
| KR20120099509A (ko) | 2009-12-29 | 2012-09-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 재조합 숙주 세포에서 육탄당 키나아제의 발현 |
| US9297016B2 (en) | 2010-02-17 | 2016-03-29 | Butamax Advanced Biofuels Llc | Activity of Fe—S cluster requiring proteins |
| AU2011268220B2 (en) | 2010-06-18 | 2015-01-29 | Butamax(Tm) Advanced Biofuels Llc | Extraction solvents derived from oil for alcohol removal in extractive fermentation |
| EP3269806B1 (en) | 2010-09-07 | 2020-05-27 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
| BRPI1004630B1 (pt) * | 2010-11-12 | 2019-01-02 | Jose Antonio Fabre | fonte energética líquida com iniciação por compressão |
| US8759044B2 (en) | 2011-03-23 | 2014-06-24 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
| US8765425B2 (en) | 2011-03-23 | 2014-07-01 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
| CA2831130C (en) | 2011-03-24 | 2021-10-26 | Butamax (Tm) Advanced Biofuels Llc | Host cells and methods for production of isobutanol |
| MX2013014327A (es) | 2011-06-17 | 2014-01-23 | Butamax Tm Advanced Biofuels | Coproductos de procesos de produccion de biocombustible y metodos para elaborarlos. |
| JP6093764B2 (ja) * | 2011-07-28 | 2017-03-08 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ケトイソ吉草酸デカルボキシラーゼ酵素およびその使用方法 |
| AU2012362144A1 (en) | 2011-12-30 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Genetic switches for butanol production |
| CA2861613A1 (en) | 2011-12-30 | 2013-07-04 | Butamax Advanced Biofuels Llc | Fermentative production of alcohols |
| CN104284981A (zh) | 2012-03-23 | 2015-01-14 | 布特马斯先进生物燃料有限责任公司 | 在针对产丁醇生物的培养基中补充乙酸盐 |
| WO2013176909A2 (en) | 2012-05-11 | 2013-11-28 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| BR112015003701A2 (pt) | 2012-08-22 | 2017-12-12 | Butamax Advanced Biofuels Llc | células hospedeiras recombinantes, método para aprimoramento, processo para a produção de um álcool, polinucleotídeo isolado, cassete de expressão e composição |
| EP2895612A1 (en) * | 2012-09-12 | 2015-07-22 | Butamax Advanced Biofuels LLC | Processes and systems for the production of fermentation products |
| US9840724B2 (en) | 2012-09-21 | 2017-12-12 | Butamax Advanced Biofuels Llc | Production of renewable hydrocarbon compositions |
| US9512408B2 (en) | 2012-09-26 | 2016-12-06 | Butamax Advanced Biofuels Llc | Polypeptides with ketol-acid reductoisomerase activity |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| WO2014106107A2 (en) | 2012-12-28 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Dhad variants for butanol production |
| WO2014159309A1 (en) | 2013-03-12 | 2014-10-02 | Butamax Advanced Biofuels Llc | Processes and systems for the production of alcohols |
| WO2014160050A1 (en) | 2013-03-14 | 2014-10-02 | Butamax Advanced Biofuels Llc | Glycerol 3- phosphate dehydrogenase for butanol production |
| WO2014151645A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Process for maximizing biomass growth and butanol yield by feedback control |
| US9771602B2 (en) * | 2013-03-15 | 2017-09-26 | Butamax Advanced Biofuels Llc | Competitive growth and/or production advantage for butanologen microorganism |
| WO2014151190A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Dhad variants and methods of screening |
| WO2015002913A1 (en) * | 2013-07-03 | 2015-01-08 | Butamax Advanced Biofuels Llc | Partial adaptation for butanol production |
| CN103627698A (zh) * | 2013-12-05 | 2014-03-12 | 江南大学 | 乙偶姻高耐受性菌株的选育和用该菌株发酵生产乙偶姻 |
| CA2957920A1 (en) | 2014-08-11 | 2016-02-18 | Butamax Advanced Biofuels Llc | Yeast preparations and methods of making the same |
| EA035950B1 (ru) * | 2014-12-08 | 2020-09-04 | Ланцатек Нью Зилэнд Лимитед | Рекомбинантные микроорганизмы, проявляющие повышенный поток при ферментационном пути |
| CN109897871A (zh) * | 2017-12-07 | 2019-06-18 | 中国科学院大连化学物理研究所 | 一种酶法催化二元醇制备二元胺的方法 |
| CN110468092B (zh) * | 2019-08-26 | 2021-10-01 | 天津科技大学 | 一株高产l-缬氨酸的基因工程菌及其构建方法与应用 |
| CN115927136B (zh) * | 2022-08-01 | 2023-06-09 | 长江师范学院 | 一种产四甲基吡嗪的重组乳酸菌、其构建方法及其应用 |
| CN116024201B (zh) * | 2022-12-23 | 2024-03-19 | 天津大学 | α-乙酰乳酸脱羧酶突变体及其在生产乙偶姻中的应用 |
| CN116640753B (zh) * | 2023-07-20 | 2023-10-13 | 中国科学院天津工业生物技术研究所 | 丙酮酸脱羧酶基因FvPDC6及其在提高威尼斯镰刀菌菌丝蛋白产量中的应用 |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US20070031950A1 (en) | 1998-09-11 | 2007-02-08 | Winkler Aaron A | Production of D-lactic acid with yeast |
| US6432688B1 (en) | 1999-01-18 | 2002-08-13 | Daicel Chemical Industries, Ltd. | Amino alcohol dehydrogenase converts keto alcohol to amino alcohol and amino alcohol to keto alcohol |
| US7405068B2 (en) | 2003-05-02 | 2008-07-29 | Tate & Lyle Ingredients Americas, Inc. | Pyruvate producing yeast strain |
| GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US8273558B2 (en) | 2005-10-26 | 2012-09-25 | Butamax(Tm) Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US9303225B2 (en) | 2005-10-26 | 2016-04-05 | Butamax Advanced Biofuels Llc | Method for the production of isobutanol by recombinant yeast |
| NZ566406A (en) | 2005-10-26 | 2012-04-27 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| US8206970B2 (en) | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| US8828704B2 (en) | 2006-05-02 | 2014-09-09 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US7659104B2 (en) | 2006-05-05 | 2010-02-09 | E.I. Du Pont De Nemours And Company | Solvent tolerant microorganisms and methods of isolation |
| US7541173B2 (en) | 2006-06-15 | 2009-06-02 | E.I. Du Pont De Nemours And Company | Solvent tolerant microorganisms and methods of isolation |
| US8017364B2 (en) | 2006-12-12 | 2011-09-13 | Butamax(Tm) Advanced Biofuels Llc | Solvent tolerant microorganisms |
| KR101573775B1 (ko) | 2007-04-18 | 2015-12-04 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산 |
| US8426174B2 (en) * | 2007-05-02 | 2013-04-23 | Butamax(Tm) Advanced Biofuels Llc | Method for the production of 2-butanol |
| US20080274522A1 (en) * | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of 2-butanone |
| EP2677028B1 (en) | 2007-12-20 | 2016-03-09 | Butamax (TM) Advanced Biofuels LLC | Ketol-acid reductoisomerase using NADH |
| US8518678B2 (en) | 2007-12-21 | 2013-08-27 | Butamax(Tm) Advanced Biofuels Llc | Strain comprising increased expression of a CFA coding region for butanol production |
| US8372612B2 (en) | 2007-12-21 | 2013-02-12 | Butamax(Tm) Advanced Biofuels Llc | Production of four carbon alcohols using improved strain |
| US20090162911A1 (en) | 2007-12-21 | 2009-06-25 | E.I. Du Pont De Nemours And Company | Strain for butanol production |
| US8455239B2 (en) | 2007-12-23 | 2013-06-04 | Gevo, Inc. | Yeast organism producing isobutanol at a high yield |
| DE102008010121B4 (de) * | 2008-02-20 | 2013-11-21 | Butalco Gmbh | Fermentative Produktion von Isobutanol mit Hefe |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| US8389252B2 (en) | 2008-05-12 | 2013-03-05 | Butamax(Tm) Advanced Biofuels Llc | Yeast strain for production of four carbon alcohols |
| US8906666B2 (en) | 2008-05-22 | 2014-12-09 | Butamax Advanced Biofuels Llc | Engineering resistance to aliphatic alcohols |
| US8828695B2 (en) | 2008-06-04 | 2014-09-09 | Butamax Advanced Biofuels Llc | Method for producing butanol using two-phase extractive fermentation |
| BRPI0909964A2 (pt) * | 2008-06-04 | 2017-06-13 | Butamax Advanced Biofuels Llc | "hospedeiro de produção entérico para a produção de isobutanol e método para a produção de isobutanol" |
| NZ588988A (en) * | 2008-06-04 | 2012-08-31 | Butamax Tm Advanced Biofuels | A method for producing butanol using two-phase extractive fermentation |
| BRPI0909989A2 (pt) | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
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| MX2011003238A (es) | 2008-09-29 | 2011-04-28 | Butamax Tm Advanced Biofuels | Identificacion y uso de dihidroxiacido deshidratasas [2fe-2s] bacterianas. |
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| WO2010037105A1 (en) | 2008-09-29 | 2010-04-01 | Butamax™ Advanced Biofuels LLC | Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria |
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| BRPI0914521A2 (pt) | 2008-10-27 | 2016-07-26 | Butamax Advanced Biofuels Llc | célula hospedeira microbiana recombinante, método de aumento da produção de isobutanol e método de produção de isobutanol |
| US8465964B2 (en) | 2008-11-13 | 2013-06-18 | Butamax (TM) Advanced Biofules LLC | Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis |
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| US8795992B2 (en) | 2008-12-29 | 2014-08-05 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving cell wall integrity pathway |
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| US20110097773A1 (en) | 2009-04-13 | 2011-04-28 | Butamax(Tm) Advanced Biofuels Llc | Method for producing butanol using extractive fermentation |
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| IN2012DN02396A (enExample) | 2009-09-29 | 2015-08-21 | Butamax Tm Advanced Biofuels | |
| US20110244536A1 (en) | 2009-09-29 | 2011-10-06 | Butamax(Tm) Advanced Biofuels Llc | Fermentive production of isobutanol using highly effective ketol-acid reductoisomerase enzymes |
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| CN102762722B (zh) | 2009-12-29 | 2015-05-20 | 布特马斯先进生物燃料有限责任公司 | 用于发酵生产低级烷基醇的醇脱氢酶(adh) |
| US9297016B2 (en) | 2010-02-17 | 2016-03-29 | Butamax Advanced Biofuels Llc | Activity of Fe—S cluster requiring proteins |
| BR112012031847A2 (pt) | 2010-06-17 | 2016-02-16 | Butamax Tm Advanced Biofuels | cultura de produção para a produção fermentativa de butanol, método de produção de butanol, método para a produção de butanol, método para aumentar a tolerância de uma cultura de produção para a produção fermentativa de butanol e cultura de produção para produção fermentativa de butanol |
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| EP3269806B1 (en) * | 2010-09-07 | 2020-05-27 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
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| JP6093764B2 (ja) | 2011-07-28 | 2017-03-08 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ケトイソ吉草酸デカルボキシラーゼ酵素およびその使用方法 |
| CA2861613A1 (en) | 2011-12-30 | 2013-07-04 | Butamax Advanced Biofuels Llc | Fermentative production of alcohols |
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| CN104284981A (zh) | 2012-03-23 | 2015-01-14 | 布特马斯先进生物燃料有限责任公司 | 在针对产丁醇生物的培养基中补充乙酸盐 |
| WO2013176909A2 (en) | 2012-05-11 | 2013-11-28 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
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| US9512408B2 (en) | 2012-09-26 | 2016-12-06 | Butamax Advanced Biofuels Llc | Polypeptides with ketol-acid reductoisomerase activity |
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| US20160326552A1 (en) | 2013-12-31 | 2016-11-10 | Butamax Advanced Biofuels Llc | Expression of a hap transcriptional complex subunit |
| US20160326551A1 (en) | 2013-12-31 | 2016-11-10 | Butamax Advanced Biofuels Llc | Isobutanol tolerance in yeast with an altered lipid profile |
-
2011
- 2011-09-07 EP EP17188003.2A patent/EP3269806B1/en not_active Not-in-force
- 2011-09-07 EP EP11824066.2A patent/EP2614138B1/en not_active Not-in-force
- 2011-09-07 CN CN201610286698.7A patent/CN105950525A/zh active Pending
- 2011-09-07 WO PCT/US2011/050689 patent/WO2012033832A2/en not_active Ceased
- 2011-09-07 JP JP2013528269A patent/JP6008858B2/ja active Active
- 2011-09-07 KR KR1020137008786A patent/KR20130105649A/ko not_active Withdrawn
- 2011-09-07 NZ NZ707800A patent/NZ707800A/en not_active IP Right Cessation
- 2011-09-07 CA CA2810244A patent/CA2810244C/en not_active Expired - Fee Related
- 2011-09-07 MX MX2013002559A patent/MX346408B/es active IP Right Grant
- 2011-09-07 BR BR112013005386A patent/BR112013005386A2/pt not_active IP Right Cessation
- 2011-09-07 AU AU2011299303A patent/AU2011299303B2/en not_active Ceased
- 2011-09-07 NZ NZ722791A patent/NZ722791A/en not_active IP Right Cessation
- 2011-09-07 MX MX2017003595A patent/MX356668B/es unknown
- 2011-09-07 US US13/227,016 patent/US9267157B2/en active Active
- 2011-09-07 CA CA3014993A patent/CA3014993A1/en not_active Abandoned
- 2011-09-07 CN CN2011800423458A patent/CN103080298A/zh active Pending
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2013
- 2013-02-18 ZA ZA2013/01237A patent/ZA201301237B/en unknown
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2016
- 2016-01-08 US US14/991,512 patent/US9765365B2/en active Active
- 2016-05-25 AU AU2016203445A patent/AU2016203445B2/en not_active Ceased
- 2016-07-13 JP JP2016138178A patent/JP6266707B2/ja not_active Expired - Fee Related
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2017
- 2017-08-07 US US15/670,825 patent/US10184139B2/en active Active
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2018
- 2018-11-21 US US16/198,355 patent/US20190100777A1/en not_active Abandoned
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