JP2014500724A5 - - Google Patents
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- JP2014500724A5 JP2014500724A5 JP2013538972A JP2013538972A JP2014500724A5 JP 2014500724 A5 JP2014500724 A5 JP 2014500724A5 JP 2013538972 A JP2013538972 A JP 2013538972A JP 2013538972 A JP2013538972 A JP 2013538972A JP 2014500724 A5 JP2014500724 A5 JP 2014500724A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acids
- protein
- homologous
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001413 amino acids Chemical class 0.000 claims description 159
- 102000004169 proteins and genes Human genes 0.000 claims description 138
- 108090000623 proteins and genes Proteins 0.000 claims description 138
- 239000012634 fragment Substances 0.000 claims description 68
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 60
- 230000002163 immunogen Effects 0.000 claims description 57
- 125000000539 amino acid group Chemical group 0.000 claims description 55
- 150000007523 nucleic acids Chemical class 0.000 claims description 50
- 108020004707 nucleic acids Proteins 0.000 claims description 41
- 102000039446 nucleic acids Human genes 0.000 claims description 41
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 26
- 108091026890 Coding region Proteins 0.000 claims description 23
- 239000002773 nucleotide Substances 0.000 claims description 22
- 125000003729 nucleotide group Chemical group 0.000 claims description 22
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 13
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 239000013604 expression vector Substances 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 4
- 239000000427 antigen Substances 0.000 description 33
- 102000036639 antigens Human genes 0.000 description 33
- 108091007433 antigens Proteins 0.000 description 33
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 21
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 16
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 16
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 12
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 description 10
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 description 10
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 description 6
- 102100036735 Prostate stem cell antigen Human genes 0.000 description 6
- 102000046689 human FOLH1 Human genes 0.000 description 5
- 101710145634 Antigen 1 Proteins 0.000 description 2
- 101000605534 Homo sapiens Prostate-specific antigen Proteins 0.000 description 2
- 101000592517 Homo sapiens Puromycin-sensitive aminopeptidase Proteins 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41317610P | 2010-11-12 | 2010-11-12 | |
| US61/413,176 | 2010-11-12 | ||
| US41781710P | 2010-11-29 | 2010-11-29 | |
| US61/417,817 | 2010-11-29 | ||
| PCT/US2011/060592 WO2012065164A2 (en) | 2010-11-12 | 2011-11-14 | Consensus prostate antigens nucleic acid molecule encoding the same and vaccine and uses comprising the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016026602A Division JP6310952B2 (ja) | 2010-11-12 | 2016-02-16 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500724A JP2014500724A (ja) | 2014-01-16 |
| JP2014500724A5 true JP2014500724A5 (enExample) | 2014-12-18 |
| JP6077450B2 JP6077450B2 (ja) | 2017-02-08 |
Family
ID=46051609
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538972A Active JP6077450B2 (ja) | 2010-11-12 | 2011-11-14 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2016026602A Active JP6310952B2 (ja) | 2010-11-12 | 2016-02-16 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2017222784A Active JP7142427B2 (ja) | 2010-11-12 | 2017-11-20 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2020046459A Active JP7572152B2 (ja) | 2010-11-12 | 2020-03-17 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2020211554A Withdrawn JP2021045171A (ja) | 2010-11-12 | 2020-12-21 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2023160203A Pending JP2023171837A (ja) | 2010-11-12 | 2023-09-25 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2025178788A Pending JP2026012855A (ja) | 2010-11-12 | 2025-10-23 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016026602A Active JP6310952B2 (ja) | 2010-11-12 | 2016-02-16 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2017222784A Active JP7142427B2 (ja) | 2010-11-12 | 2017-11-20 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2020046459A Active JP7572152B2 (ja) | 2010-11-12 | 2020-03-17 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2020211554A Withdrawn JP2021045171A (ja) | 2010-11-12 | 2020-12-21 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2023160203A Pending JP2023171837A (ja) | 2010-11-12 | 2023-09-25 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
| JP2025178788A Pending JP2026012855A (ja) | 2010-11-12 | 2025-10-23 | コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途 |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US8927692B2 (enExample) |
| EP (3) | EP3909973A3 (enExample) |
| JP (7) | JP6077450B2 (enExample) |
| KR (5) | KR102557275B1 (enExample) |
| CN (2) | CN106434676B (enExample) |
| AU (1) | AU2011325893B2 (enExample) |
| BR (1) | BR112013011705B1 (enExample) |
| CA (1) | CA2817709C (enExample) |
| DK (1) | DK2638055T3 (enExample) |
| EA (1) | EA027315B1 (enExample) |
| ES (1) | ES2718846T3 (enExample) |
| MX (3) | MX346784B (enExample) |
| PL (1) | PL3536703T3 (enExample) |
| SI (1) | SI3536703T1 (enExample) |
| WO (1) | WO2012065164A2 (enExample) |
| ZA (1) | ZA201303390B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| EP4108671B1 (en) | 2010-10-01 | 2024-11-20 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| CA2817709C (en) | 2010-11-12 | 2021-06-01 | The Trustees Of The University Of Pennsylvania | Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| PL3682905T3 (pl) | 2011-10-03 | 2022-04-04 | Modernatx, Inc. | Modyfikowane nukleozydy, nukleotydy i kwasy nukleinowe oraz ich zastosowania |
| PL2791160T3 (pl) | 2011-12-16 | 2022-06-20 | Modernatx, Inc. | Kompozycje zmodyfikowanego mrna |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| PT2844282T (pt) * | 2012-05-04 | 2019-07-23 | Pfizer | Antigénios associados à próstata e regimes de imunoterapêutica baseados em vacinas |
| RS63237B1 (sr) | 2012-11-26 | 2022-06-30 | Modernatx Inc | Terminalno modifikovana rnk |
| PL2931304T3 (pl) * | 2012-12-13 | 2021-11-08 | The Trustees Of The University Of Pennsylvania | Szczepionka wt1 |
| EA201591131A1 (ru) * | 2012-12-13 | 2015-12-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Днк-конструкции антитела и способ их применения |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| JP6769865B2 (ja) * | 2013-03-15 | 2020-10-14 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | ガンワクチン及びそれを用いた治療方法 |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| ES2715890T3 (es) * | 2013-11-01 | 2019-06-06 | Pfizer | Vectores de expresión de antígenos asociados a la próstata |
| LT4023249T (lt) | 2014-04-23 | 2025-01-10 | Modernatx, Inc. | Nuleorūgšties vakcinos |
| KR20170085131A (ko) | 2014-12-01 | 2017-07-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Dna 항체 작제물 및 그 이용 방법 |
| MA42543A (fr) | 2015-07-30 | 2018-06-06 | Modernatx Inc | Arn épitope peptidiques concatémériques |
| KR20230012070A (ko) * | 2016-03-21 | 2023-01-25 | 데이비드 비. 웨이너 | Dna 항체 작제물 및 이의 사용 방법 |
| KR20190034503A (ko) * | 2016-06-03 | 2019-04-02 | 이투빅스 코포레이션 | 전립선암-연관 항원을 사용한 종양 백신접종을 위한 조성물 및 방법 |
| CN106119231A (zh) * | 2016-06-24 | 2016-11-16 | 安徽未名细胞治疗有限公司 | 一种肿瘤抗原psa的ctl识别表位肽及其应用 |
| CN106581668B (zh) * | 2016-12-31 | 2020-03-24 | 广州姿生生物科技有限公司 | 一种抗原表位肽组合物及其应用 |
| JP2021506255A (ja) * | 2017-12-13 | 2021-02-22 | イノビオ ファーマシューティカルズ，インコーポレイティド | Ｐｒａｍｅを標的とするがんワクチンおよびその使用 |
| CN111308327B (zh) * | 2019-12-02 | 2021-01-26 | 电子科技大学 | 模拟电路故障定位与故障元件参数辨识方法 |
| EP4306641A4 (en) * | 2021-02-05 | 2025-06-04 | ST Pharm Co., Ltd. | NEW NUCLEIC ACID MOLECULE |
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