JP2020502075A5 - - Google Patents
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- JP2020502075A5 JP2020502075A5 JP2019528878A JP2019528878A JP2020502075A5 JP 2020502075 A5 JP2020502075 A5 JP 2020502075A5 JP 2019528878 A JP2019528878 A JP 2019528878A JP 2019528878 A JP2019528878 A JP 2019528878A JP 2020502075 A5 JP2020502075 A5 JP 2020502075A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- ahd
- prd
- family
- pspa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 6
- 229960005486 vaccine Drugs 0.000 claims 5
- 230000002163 immunogen Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 150000004676 glycans Chemical class 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 2
- 102400000368 Surface protein Human genes 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 229920001218 Pullulan Polymers 0.000 claims 1
- 239000004373 Pullulan Substances 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 238000003491 array Methods 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 235000019423 pullulan Nutrition 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662429782P | 2016-12-03 | 2016-12-03 | |
| US62/429,782 | 2016-12-03 | ||
| PCT/US2017/064347 WO2018102774A2 (en) | 2016-12-03 | 2017-12-01 | Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502075A JP2020502075A (ja) | 2020-01-23 |
| JP2020502075A5 true JP2020502075A5 (enExample) | 2021-07-26 |
| JP7246644B2 JP7246644B2 (ja) | 2023-03-28 |
Family
ID=61028164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019528878A Active JP7246644B2 (ja) | 2016-12-03 | 2017-12-01 | 肺炎球菌表面プロテインａの選択されたアルファヘリカルドメインおよびプロリンリッチドメインを組み合わせた肺炎球菌ワクチン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11806392B2 (enExample) |
| EP (1) | EP3548076A2 (enExample) |
| JP (1) | JP7246644B2 (enExample) |
| KR (1) | KR102608642B1 (enExample) |
| CN (1) | CN110381992A (enExample) |
| AU (2) | AU2017366726B2 (enExample) |
| WO (1) | WO2018102774A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3548076A2 (en) | 2016-12-03 | 2019-10-09 | The UAB Research Foundation | Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a |
| US12280098B2 (en) * | 2019-03-29 | 2025-04-22 | The University Of Tokyo | Pneumococcal surface proteins |
| CN110452374B (zh) * | 2019-08-30 | 2021-09-28 | 苏州大学 | 具有高效基因递送能力的三维球形α螺旋阳离子聚多肽及其制备方法与应用 |
| JP2024545092A (ja) | 2021-12-08 | 2024-12-05 | イミュニティバイオ，インコーポレーテッド | ネオエピトープワクチン送達賦形剤及びそれを製造する方法 |
| CN121693342A (zh) | 2023-07-12 | 2026-03-17 | 维罗迈科斯股份公司 | 肺炎球菌抗原的组合物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0786521A1 (en) * | 1991-02-15 | 1997-07-30 | Uab Research Foundation | Nucleic acid encoding PspA |
| US5980909A (en) | 1991-02-15 | 1999-11-09 | Uab Research Foundation | Epitopic regions of pneumococcal surface protein A |
| US6592876B1 (en) * | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
| US5476929A (en) | 1991-02-15 | 1995-12-19 | Uab Research Foundation | Structural gene of pneumococcal protein |
| US5955089A (en) | 1993-04-20 | 1999-09-21 | Uab Research Foundation | Strain selection of pneumococcal surface proteins |
| CA2116261A1 (en) * | 1993-04-20 | 1994-10-21 | David E. Briles | Epitopic regions of pneumococcal surface protein a |
| AU2007211329B2 (en) | 2006-02-02 | 2012-09-13 | The Uab Research Foundation | Non-coiled protective regions of pneumococcal surface proteins PSPA and PSPC |
| JP5344558B2 (ja) | 2008-10-31 | 2013-11-20 | 国立大学法人 東京医科歯科大学 | カチオン性ナノゲルを用いる粘膜ワクチン |
| EP2788078B1 (en) | 2011-12-09 | 2020-09-02 | Metavention, Inc. | Therapeutic neuromodulation of the hepatic system |
| RU2510281C2 (ru) | 2012-06-22 | 2014-03-27 | Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") | ВАКЦИНА ПРОТИВ ПНЕВМОНИИ, ВЫЗЫВАЕМОЙ Streptococcus pneumoniae, НА ОСНОВЕ ГИБРИДНОГО БЕЛКА |
| US9938326B2 (en) | 2012-09-19 | 2018-04-10 | Osaka University | Pneumococcal vaccine containing pneumococcal surface protein A |
| BR112016012306A2 (pt) * | 2013-12-03 | 2017-09-26 | Swiss Tropical And Public Health Inst | peptídeos ricos em prolina para proteção contra s. pneumoniae |
| CA2933909C (en) | 2013-12-18 | 2024-07-02 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising long chain polyunsaturated fatty acids |
| CN103834667B (zh) * | 2013-12-31 | 2016-08-17 | 李越希 | 化学合成的肺炎链球菌PspA蛋白胞外区基因片段及其表达、应用 |
| JP6310720B2 (ja) | 2014-02-17 | 2018-04-11 | 知的財産戦略ネットワーク株式会社 | 肺炎球菌経鼻ワクチン |
| CN104888224B (zh) * | 2015-03-25 | 2019-02-01 | 中山大学 | 一种两亲性多糖衍生物/泊洛沙姆温敏型原位水凝胶及其制备方法 |
| CN104844712B (zh) * | 2015-04-03 | 2019-06-28 | 长春百克生物科技股份公司 | 肺炎链球菌蛋白抗原及其制备方法和应用 |
| EP3548076A2 (en) | 2016-12-03 | 2019-10-09 | The UAB Research Foundation | Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a |
-
2017
- 2017-12-01 EP EP17835741.4A patent/EP3548076A2/en active Pending
- 2017-12-01 CN CN201780086110.6A patent/CN110381992A/zh active Pending
- 2017-12-01 AU AU2017366726A patent/AU2017366726B2/en active Active
- 2017-12-01 JP JP2019528878A patent/JP7246644B2/ja active Active
- 2017-12-01 WO PCT/US2017/064347 patent/WO2018102774A2/en not_active Ceased
- 2017-12-01 KR KR1020197019223A patent/KR102608642B1/ko active Active
- 2017-12-01 US US16/463,364 patent/US11806392B2/en active Active
-
2021
- 2021-11-16 AU AU2021269320A patent/AU2021269320A1/en not_active Abandoned