CN110381992A - 组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗 - Google Patents

组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗 Download PDF

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Publication number
CN110381992A
CN110381992A CN201780086110.6A CN201780086110A CN110381992A CN 110381992 A CN110381992 A CN 110381992A CN 201780086110 A CN201780086110 A CN 201780086110A CN 110381992 A CN110381992 A CN 110381992A
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lys
ala
leu
asp
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Chinese (zh)
Inventor
D·E·布莱利斯
清野宏
罗伯特·科内尔
瑞西米·穆科吉
克里斯托弗·根施默尔
幸義和
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The University of Tokyo
UAB Research Foundation
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The University of Tokyo
UAB Research Foundation
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Publication of CN110381992A publication Critical patent/CN110381992A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780086110.6A 2016-12-03 2017-12-01 组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗 Pending CN110381992A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662429782P 2016-12-03 2016-12-03
US62/429,782 2016-12-03
PCT/US2017/064347 WO2018102774A2 (en) 2016-12-03 2017-12-01 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Publications (1)

Publication Number Publication Date
CN110381992A true CN110381992A (zh) 2019-10-25

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CN201780086110.6A Pending CN110381992A (zh) 2016-12-03 2017-12-01 组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗

Country Status (7)

Country Link
US (1) US11806392B2 (enExample)
EP (1) EP3548076A2 (enExample)
JP (1) JP7246644B2 (enExample)
KR (1) KR102608642B1 (enExample)
CN (1) CN110381992A (enExample)
AU (2) AU2017366726B2 (enExample)
WO (1) WO2018102774A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11806392B2 (en) 2016-12-03 2023-11-07 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A

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CA3130470A1 (en) * 2019-03-29 2020-10-08 Yoshikazu Yuki Pneumococcal surface proteins
CN110452374B (zh) * 2019-08-30 2021-09-28 苏州大学 具有高效基因递送能力的三维球形α螺旋阳离子聚多肽及其制备方法与应用
US12409135B2 (en) 2021-12-08 2025-09-09 Immunitybio, Inc. Neoepitope vaccine delivery vehicle and methods of making the same
CN121693342A (zh) 2023-07-12 2026-03-17 维罗迈科斯股份公司 肺炎球菌抗原的组合物

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US5728387A (en) * 1991-02-15 1998-03-17 University Of Alabama At Birmingham Research Foundation Structural gene of pneumococcal protein
US5753463A (en) * 1991-02-15 1998-05-19 Uab Research Foundation Structural gene of pneumococcal protein
US6500613B1 (en) * 1995-09-15 2002-12-31 University Of Alabama At Birmingham Pneumococcal surface proteins and uses thereof
CN103834667A (zh) * 2013-12-31 2014-06-04 李越希 化学合成的肺炎链球菌PspA蛋白胞外区基因片段及其表达、应用
CN104812405A (zh) * 2012-09-19 2015-07-29 国立大学法人大阪大学 含有肺炎球菌表面蛋白a的肺炎球菌疫苗
CN104844712A (zh) * 2015-04-03 2015-08-19 长春百克生物科技股份公司 肺炎链球菌蛋白抗原及其制备方法和应用
CN104888224A (zh) * 2015-03-25 2015-09-09 中山大学 一种两亲性多糖衍生物/泊洛沙姆温敏型原位水凝胶及其制备方法

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US5955089A (en) 1993-04-20 1999-09-21 Uab Research Foundation Strain selection of pneumococcal surface proteins
WO2007089866A2 (en) * 2006-02-02 2007-08-09 University Of Alabama Research Foundation Non-coiled protective regions of pneumococcal surface proteins pspa and pspc
JP5344558B2 (ja) 2008-10-31 2013-11-20 国立大学法人 東京医科歯科大学 カチオン性ナノゲルを用いる粘膜ワクチン
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HK1225739A1 (zh) * 2013-12-03 2017-09-15 Virometix Ag 针对肺炎链球菌进行保护的富含脯氨酸的肽
KR102386838B1 (ko) 2013-12-18 2022-04-15 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 장쇄 다중불포화 지방산을 포함하는 지질
JP6310720B2 (ja) 2014-02-17 2018-04-11 知的財産戦略ネットワーク株式会社 肺炎球菌経鼻ワクチン
CN110381992A (zh) 2016-12-03 2019-10-25 Uab研究基金会 组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗

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EP0622081A2 (en) * 1993-04-20 1994-11-02 The Uab Research Foundation Epitopic regions of phneumococcal surface protein A
US6500613B1 (en) * 1995-09-15 2002-12-31 University Of Alabama At Birmingham Pneumococcal surface proteins and uses thereof
CN104812405A (zh) * 2012-09-19 2015-07-29 国立大学法人大阪大学 含有肺炎球菌表面蛋白a的肺炎球菌疫苗
CN103834667A (zh) * 2013-12-31 2014-06-04 李越希 化学合成的肺炎链球菌PspA蛋白胞外区基因片段及其表达、应用
CN104888224A (zh) * 2015-03-25 2015-09-09 中山大学 一种两亲性多糖衍生物/泊洛沙姆温敏型原位水凝胶及其制备方法
CN104844712A (zh) * 2015-04-03 2015-08-19 长春百克生物科技股份公司 肺炎链球菌蛋白抗原及其制备方法和应用

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11806392B2 (en) 2016-12-03 2023-11-07 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A

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RU2019118969A3 (enExample) 2021-01-11
US20190351043A1 (en) 2019-11-21
CA3044112A1 (en) 2018-06-07
KR102608642B1 (ko) 2023-11-30
EP3548076A2 (en) 2019-10-09
WO2018102774A2 (en) 2018-06-07
AU2017366726B2 (en) 2021-12-09
JP7246644B2 (ja) 2023-03-28
AU2017366726A1 (en) 2019-05-30
WO2018102774A3 (en) 2018-07-12
WO2018102774A8 (en) 2019-05-31
JP2020502075A (ja) 2020-01-23
KR20190110090A (ko) 2019-09-27
AU2021269320A1 (en) 2021-12-09
US11806392B2 (en) 2023-11-07
RU2019118969A (ru) 2021-01-11

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