CN110381992A - 组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗 - Google Patents

组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗 Download PDF

Info

Publication number
CN110381992A
CN110381992A CN201780086110.6A CN201780086110A CN110381992A CN 110381992 A CN110381992 A CN 110381992A CN 201780086110 A CN201780086110 A CN 201780086110A CN 110381992 A CN110381992 A CN 110381992A
Authority
CN
China
Prior art keywords
glu
lys
ala
leu
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780086110.6A
Other languages
English (en)
Chinese (zh)
Inventor
D·E·布莱利斯
清野宏
罗伯特·科内尔
瑞西米·穆科吉
克里斯托弗·根施默尔
幸義和
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tokyo NUC
UAB Research Foundation
Original Assignee
University of Tokyo NUC
UAB Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tokyo NUC, UAB Research Foundation filed Critical University of Tokyo NUC
Publication of CN110381992A publication Critical patent/CN110381992A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780086110.6A 2016-12-03 2017-12-01 组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗 Pending CN110381992A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662429782P 2016-12-03 2016-12-03
US62/429,782 2016-12-03
PCT/US2017/064347 WO2018102774A2 (en) 2016-12-03 2017-12-01 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Publications (1)

Publication Number Publication Date
CN110381992A true CN110381992A (zh) 2019-10-25

Family

ID=61028164

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780086110.6A Pending CN110381992A (zh) 2016-12-03 2017-12-01 组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗

Country Status (8)

Country Link
US (1) US11806392B2 (enExample)
EP (1) EP3548076A2 (enExample)
JP (1) JP7246644B2 (enExample)
KR (1) KR102608642B1 (enExample)
CN (1) CN110381992A (enExample)
AU (2) AU2017366726B2 (enExample)
CA (1) CA3044112A1 (enExample)
WO (1) WO2018102774A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11806392B2 (en) 2016-12-03 2023-11-07 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3949985A4 (en) * 2019-03-29 2022-12-28 The University of Tokyo PNEUMOCOCCAL SURFACE PROTEINS
CN110452374B (zh) 2019-08-30 2021-09-28 苏州大学 具有高效基因递送能力的三维球形α螺旋阳离子聚多肽及其制备方法与应用
CA3237203A1 (en) 2021-12-08 2023-06-15 Immunitybio, Inc. Neoepitope vaccine delivery vehicle and methods of making the same
WO2025012364A1 (en) 2023-07-12 2025-01-16 Virometix Ag Compositions of pneumococcal antigens

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0622081A2 (en) * 1993-04-20 1994-11-02 The Uab Research Foundation Epitopic regions of phneumococcal surface protein A
US5728387A (en) * 1991-02-15 1998-03-17 University Of Alabama At Birmingham Research Foundation Structural gene of pneumococcal protein
US5753463A (en) * 1991-02-15 1998-05-19 Uab Research Foundation Structural gene of pneumococcal protein
US6500613B1 (en) * 1995-09-15 2002-12-31 University Of Alabama At Birmingham Pneumococcal surface proteins and uses thereof
CN103834667A (zh) * 2013-12-31 2014-06-04 李越希 化学合成的肺炎链球菌PspA蛋白胞外区基因片段及其表达、应用
CN104812405A (zh) * 2012-09-19 2015-07-29 国立大学法人大阪大学 含有肺炎球菌表面蛋白a的肺炎球菌疫苗
CN104844712A (zh) * 2015-04-03 2015-08-19 长春百克生物科技股份公司 肺炎链球菌蛋白抗原及其制备方法和应用
CN104888224A (zh) * 2015-03-25 2015-09-09 中山大学 一种两亲性多糖衍生物/泊洛沙姆温敏型原位水凝胶及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980909A (en) 1991-02-15 1999-11-09 Uab Research Foundation Epitopic regions of pneumococcal surface protein A
US5955089A (en) 1993-04-20 1999-09-21 Uab Research Foundation Strain selection of pneumococcal surface proteins
JP2009525047A (ja) 2006-02-02 2009-07-09 ザ ユーエイビー リサーチ ファウンデイション 肺炎レンサ球菌表面タンパク質ｐｓｐａおよびｐｓｐｃの非−コイル保護領域
JP5344558B2 (ja) 2008-10-31 2013-11-20 国立大学法人 東京医科歯科大学 カチオン性ナノゲルを用いる粘膜ワクチン
KR102067583B1 (ko) 2011-12-09 2020-01-17 메타벤션, 인크. 간 시스템의 치료적 신경조절
RU2510281C2 (ru) 2012-06-22 2014-03-27 Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") ВАКЦИНА ПРОТИВ ПНЕВМОНИИ, ВЫЗЫВАЕМОЙ Streptococcus pneumoniae, НА ОСНОВЕ ГИБРИДНОГО БЕЛКА
KR20160088323A (ko) * 2013-12-03 2016-07-25 비로메틱스 아게 S. 뉴모니에(S. pneumoniae)에 대항하는 보호성 프롤린-풍부한 펩티드
CA3241340A1 (en) * 2013-12-18 2015-06-25 Grains Research And Development Corporation Lipid comprising long chain polyunsaturated fatty acids
JP6310720B2 (ja) * 2014-02-17 2018-04-11 知的財産戦略ネットワーク株式会社 肺炎球菌経鼻ワクチン
AU2017366726B2 (en) 2016-12-03 2021-12-09 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728387A (en) * 1991-02-15 1998-03-17 University Of Alabama At Birmingham Research Foundation Structural gene of pneumococcal protein
US5753463A (en) * 1991-02-15 1998-05-19 Uab Research Foundation Structural gene of pneumococcal protein
EP0622081A2 (en) * 1993-04-20 1994-11-02 The Uab Research Foundation Epitopic regions of phneumococcal surface protein A
US6500613B1 (en) * 1995-09-15 2002-12-31 University Of Alabama At Birmingham Pneumococcal surface proteins and uses thereof
CN104812405A (zh) * 2012-09-19 2015-07-29 国立大学法人大阪大学 含有肺炎球菌表面蛋白a的肺炎球菌疫苗
CN103834667A (zh) * 2013-12-31 2014-06-04 李越希 化学合成的肺炎链球菌PspA蛋白胞外区基因片段及其表达、应用
CN104888224A (zh) * 2015-03-25 2015-09-09 中山大学 一种两亲性多糖衍生物/泊洛沙姆温敏型原位水凝胶及其制备方法
CN104844712A (zh) * 2015-04-03 2015-08-19 长春百克生物科技股份公司 肺炎链球菌蛋白抗原及其制备方法和应用

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
CALVIN C DANIELS等: "The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsis", 《INFECTION AND IMMUNITY》, vol. 78, no. 5, pages 2163 - 2164 *
G S NABORS等: "《Immunization of healthy adults with a single recombinant pneumococcal surface protein A (PspA) variant stimulates broadly cross-reactive antibodies to heterologous PspA molecules》", 《VACCINE》 *
G S NABORS等: "《Immunization of healthy adults with a single recombinant pneumococcal surface protein A (PspA) variant stimulates broadly cross-reactive antibodies to heterologous PspA molecules》", 《VACCINE》, vol. 18, no. 17, 6 March 2000 (2000-03-06), pages 1743 - 1749 *
G S NABORS等: "Immunization of healthy adults with a single recombinant pneumococcal surface protein A (PspA) variant stimulates broadly cross-reactive antibodies to heterologous PspA molecules", 《VACCINE》, vol. 18, no. 17, pages 1743 - 1745 *
M DARRIEUX等: "《Fusion proteins containing family 1 and family 2 PspA fragments elicit protection against Streptococcus pneumoniae that correlates with antibody-mediated enhancement of complement deposition》", 《INFECTION AND IMMUNITY》 *
M DARRIEUX等: "《Fusion proteins containing family 1 and family 2 PspA fragments elicit protection against Streptococcus pneumoniae that correlates with antibody-mediated enhancement of complement deposition》", 《INFECTION AND IMMUNITY》, vol. 75, no. 12, 8 October 2007 (2007-10-08), pages 5930 - 5938 *
NCBI: "《KYA26723.1》", 《GENPEPT》 *
NCBI: "《KYA26723.1》", 《GENPEPT》, 10 March 2016 (2016-03-10), pages 1 - 2 *
WEI XIN等: "《PspA family fusion proteins delivered by attenuated Salmonella enterica serovar Typhimurium extend and enhance protection against Streptococcus pneumoniae》", 《INFECTION AND IMMUNITY》 *
WEI XIN等: "《PspA family fusion proteins delivered by attenuated Salmonella enterica serovar Typhimurium extend and enhance protection against Streptococcus pneumoniae》", 《INFECTION AND IMMUNITY》, vol. 77, no. 10, 17 August 2009 (2009-08-17), pages 4518 - 4528 *
ZHENYU PIAO等: "《Protective properties of a fusion pneumococcal surface protein A (PspA) vaccine against pneumococcal challenge by five different PspA clades in mice》", 《VACCINE》 *
ZHENYU PIAO等: "《Protective properties of a fusion pneumococcal surface protein A (PspA) vaccine against pneumococcal challenge by five different PspA clades in mice》", 《VACCINE》, vol. 32, no. 43, 12 August 2014 (2014-08-12), pages 5607 - 5613 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11806392B2 (en) 2016-12-03 2023-11-07 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A

Also Published As

Publication number Publication date
AU2017366726A1 (en) 2019-05-30
EP3548076A2 (en) 2019-10-09
WO2018102774A2 (en) 2018-06-07
JP7246644B2 (ja) 2023-03-28
WO2018102774A3 (en) 2018-07-12
US11806392B2 (en) 2023-11-07
JP2020502075A (ja) 2020-01-23
KR102608642B1 (ko) 2023-11-30
CA3044112A1 (en) 2018-06-07
WO2018102774A8 (en) 2019-05-31
RU2019118969A3 (enExample) 2021-01-11
RU2019118969A (ru) 2021-01-11
US20190351043A1 (en) 2019-11-21
KR20190110090A (ko) 2019-09-27
AU2017366726B2 (en) 2021-12-09
AU2021269320A1 (en) 2021-12-09

Similar Documents

Publication Publication Date Title
US8226953B2 (en) Group B Streptococcus antigens
CA2532369C (en) Immunogenic compositions for streptococcus pyogenes
AU2021269320A1 (en) Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a
JP2007500726A5 (enExample)
JP2005523000A (ja) 多価連鎖球菌性ワクチン組成物および使用方法
US6197929B1 (en) Carrier protein having an adjuvant effect, immunogenic complex containing it, process for their preparation, nucleotide sequence and vaccine
CN107737334A (zh) 一种预防a型链球菌感染的广谱多联亚单位疫苗
JP2001515723A (ja) Ａ群連鎖球菌ワクチン
AU761394B2 (en) Superoxide dismutase as a vaccine antigen
JP4749641B2 (ja) ワクチン用の肺炎球菌タンパク質の相同体および断片
RU2794625C2 (ru) Пневмококковая вакцина, сочетающая выбранные альфа-спиральные домены и богатые пролином домены пневмококкового поверхностного белка а
AU2007202175B2 (en) Group B Streptococcus Antigens
AU2007200130B2 (en) Group B Streptococcus Antigens
HK1100752A (en) Group b streptococcus antigens
MXPA00008111A (en) Group b streptococcus antigens

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20191025

RJ01 Rejection of invention patent application after publication