AU2017366726B2 - Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A - Google Patents

Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A Download PDF

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Publication number
AU2017366726B2
AU2017366726B2 AU2017366726A AU2017366726A AU2017366726B2 AU 2017366726 B2 AU2017366726 B2 AU 2017366726B2 AU 2017366726 A AU2017366726 A AU 2017366726A AU 2017366726 A AU2017366726 A AU 2017366726A AU 2017366726 B2 AU2017366726 B2 AU 2017366726B2
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Australia
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lys
ala
leu
asp
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AU2017366726A
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AU2017366726A1 (en
Inventor
David E. Briles
Kristopher GENSCHMER
Hiroshi Kiyono
Robert Kneller
Reshmi MUKERJI
Yoshikazu Yuki
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University of Tokyo NUC
UAB Research Foundation
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University of Tokyo NUC
UAB Research Foundation
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Priority to AU2021269320A priority Critical patent/AU2021269320A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2017366726A 2016-12-03 2017-12-01 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A Active AU2017366726B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021269320A AU2021269320A1 (en) 2016-12-03 2021-11-16 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662429782P 2016-12-03 2016-12-03
US62/429,782 2016-12-03
PCT/US2017/064347 WO2018102774A2 (en) 2016-12-03 2017-12-01 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021269320A Division AU2021269320A1 (en) 2016-12-03 2021-11-16 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Publications (2)

Publication Number Publication Date
AU2017366726A1 AU2017366726A1 (en) 2019-05-30
AU2017366726B2 true AU2017366726B2 (en) 2021-12-09

Family

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AU2017366726A Active AU2017366726B2 (en) 2016-12-03 2017-12-01 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A
AU2021269320A Abandoned AU2021269320A1 (en) 2016-12-03 2021-11-16 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Family Applications After (1)

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AU2021269320A Abandoned AU2021269320A1 (en) 2016-12-03 2021-11-16 Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Country Status (8)

Country Link
US (1) US11806392B2 (enExample)
EP (1) EP3548076A2 (enExample)
JP (1) JP7246644B2 (enExample)
KR (1) KR102608642B1 (enExample)
CN (1) CN110381992A (enExample)
AU (2) AU2017366726B2 (enExample)
CA (1) CA3044112A1 (enExample)
WO (1) WO2018102774A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3548076A2 (en) 2016-12-03 2019-10-09 The UAB Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a
CN113631186B (zh) * 2019-03-29 2024-10-29 国立大学法人东京大学 肺炎球菌表面蛋白
CN110452374B (zh) * 2019-08-30 2021-09-28 苏州大学 具有高效基因递送能力的三维球形α螺旋阳离子聚多肽及其制备方法与应用
JP2024545092A (ja) 2021-12-08 2024-12-05 イミュニティバイオ，インコーポレーテッド ネオエピトープワクチン送達賦形剤及びそれを製造する方法
WO2025012364A1 (en) 2023-07-12 2025-01-16 Virometix Ag Compositions of pneumococcal antigens

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2910251A1 (en) * 2012-09-19 2015-08-26 Osaka University Pneumococcal vaccine containing pneumococcal surface protein a

Family Cites Families (17)

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EP0571538B1 (en) * 1991-02-15 1998-07-08 The Uab Research Foundation Structural gene of pneumococcal protein
US5476929A (en) * 1991-02-15 1995-12-19 Uab Research Foundation Structural gene of pneumococcal protein
US5980909A (en) 1991-02-15 1999-11-09 Uab Research Foundation Epitopic regions of pneumococcal surface protein A
US6592876B1 (en) 1993-04-20 2003-07-15 Uab Research Foundation Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products
US5955089A (en) 1993-04-20 1999-09-21 Uab Research Foundation Strain selection of pneumococcal surface proteins
CA2116261A1 (en) 1993-04-20 1994-10-21 David E. Briles Epitopic regions of pneumococcal surface protein a
ATE536370T1 (de) 2006-02-02 2011-12-15 Univ Alabama Res Found Nicht gespulte schutzregionen der pneumokokken- oberflächenproteine pspa und pspc
JP5344558B2 (ja) 2008-10-31 2013-11-20 国立大学法人 東京医科歯科大学 カチオン性ナノゲルを用いる粘膜ワクチン
AU2012347470B2 (en) 2011-12-09 2017-02-02 Medtronic Ireland Manufacturing Unlimited Company Therapeutic neuromodulation of the hepatic system
RU2510281C2 (ru) 2012-06-22 2014-03-27 Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") ВАКЦИНА ПРОТИВ ПНЕВМОНИИ, ВЫЗЫВАЕМОЙ Streptococcus pneumoniae, НА ОСНОВЕ ГИБРИДНОГО БЕЛКА
WO2015082501A1 (en) * 2013-12-03 2015-06-11 Virometix Ag Proline-rich peptides protective against s. pneumoniae
EP3082405A4 (en) 2013-12-18 2017-12-13 Commonwealth Scientific and Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
CN103834667B (zh) 2013-12-31 2016-08-17 李越希 化学合成的肺炎链球菌PspA蛋白胞外区基因片段及其表达、应用
JP6310720B2 (ja) 2014-02-17 2018-04-11 知的財産戦略ネットワーク株式会社 肺炎球菌経鼻ワクチン
CN104888224B (zh) * 2015-03-25 2019-02-01 中山大学 一种两亲性多糖衍生物/泊洛沙姆温敏型原位水凝胶及其制备方法
CN104844712B (zh) 2015-04-03 2019-06-28 长春百克生物科技股份公司 肺炎链球菌蛋白抗原及其制备方法和应用
EP3548076A2 (en) 2016-12-03 2019-10-09 The UAB Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein a

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2910251A1 (en) * 2012-09-19 2015-08-26 Osaka University Pneumococcal vaccine containing pneumococcal surface protein a

Also Published As

Publication number Publication date
CN110381992A (zh) 2019-10-25
KR102608642B1 (ko) 2023-11-30
WO2018102774A3 (en) 2018-07-12
CA3044112A1 (en) 2018-06-07
AU2021269320A1 (en) 2021-12-09
US20190351043A1 (en) 2019-11-21
JP2020502075A (ja) 2020-01-23
RU2019118969A (ru) 2021-01-11
WO2018102774A8 (en) 2019-05-31
JP7246644B2 (ja) 2023-03-28
US11806392B2 (en) 2023-11-07
KR20190110090A (ko) 2019-09-27
AU2017366726A1 (en) 2019-05-30
RU2019118969A3 (enExample) 2021-01-11
EP3548076A2 (en) 2019-10-09
WO2018102774A2 (en) 2018-06-07

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